Automatic dropwise adding device for standard nucleic acid removing element

Abstract

The utility model relates to the technical field of dripping devices, and discloses an automatic dripping device for standard nucleic acid removing elements, which comprises a tank body and a feeding groove, one side of the tank body is communicated with the feeding groove, and a mixing component is arranged at the center of the top of the tank body; the dropwise adding assembly is arranged on one side of the top of the tank body, the dropwise adding assembly comprises a dropwise adding tank arranged on one side of the top of the tank body, one side of the dropwise adding tank is communicated with a connecting pipe, and one end of the connecting pipe penetrates through the inner wall of the tank body and is communicated with an annular flow dividing pipe; the nucleic acid removing element in the dripping tank flows into the annular flow dividing pipe from the connecting pipe by opening the flow adjusting valve, uniformly flows out from the dripping heads and is mixed with a product, and then the motor is started to drive the driving wheel to drive the driven wheel to rotate, so that the driving shaft drives the connecting shaft to rotate, and the connecting shaft synchronously drives the paddle to rotate; therefore, the mixing efficiency of the product and the nucleic acid removing element is improved.

Description

Technical Field

[0001] This utility model relates to the field of dripping device technology, specifically a standard automatic dripping device for removing nucleic acid. Background Technology

[0002] In the production of biological products (such as viral vaccines), totipotent nucleases are typically used in the purification step to remove residual host cell DNA. This reduces the amount of residual nucleic acid in the vaccine to below the limit without significantly affecting the virus's infectivity, thus ensuring the product's safety and efficacy. In general biopharmaceutical processes, when adding specific reagents (such as nucleic acid removers), a dropping device is usually used to uniformly add the reagents to the reaction system to ensure the accuracy and repeatability of the process.

[0003] However, the current dropping device has a single dropping position, which easily leads to uneven dispersion of the dropping liquid during the dropping process. This results in localized excessively high concentrations of the dropping liquid in the product, thereby reducing the mixing efficiency between the reagent and the product. Therefore, it needs to be improved. Utility Model Content

[0004] The purpose of this invention is to provide a standard automatic nucleic acid removal agent dispensing device to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a standard automatic nucleic acid removal agent dripping device, comprising a tank and a feeding trough, wherein the feeding trough is connected to one side of the tank and a mixing component is provided at the center of the top of the tank;

[0006] A dripping assembly is disposed on one side of the top of the tank. The dripping assembly includes a dripping tank disposed on one side of the top of the tank. A connecting pipe is connected to one side of the dripping tank. One end of the connecting pipe penetrates the inner wall of the tank and is connected to an annular diverter pipe.

[0007] Preferably, the dripping assembly further includes a dripping head connected to the outside of the annular diverter tube, and the number of the dripping heads is several, which are arranged in a ring.

[0008] Preferably, the dripping assembly further includes a liquid addition pipe connected to the top of the dripping tank, and a flow regulating valve is provided on the outside of the connecting pipe.

[0009] Preferably, the dripping assembly further includes a plurality of rods fixed to the top of the annular diverter tube, the tops of the plurality of rods being fixedly connected to the inner wall of the tank.

[0010] Preferably, the mixing assembly includes a housing fixed to the top of the tank, a motor is provided on one side of the housing, a drive wheel is fixedly connected to the output end of the motor, a driven wheel is meshed with the outer side of the drive wheel, a drive shaft is fixedly connected to the inner ring of the driven wheel, and the top of the drive shaft is rotatably connected to the inner wall of the housing through a bearing seat.

[0011] Preferably, the mixing assembly further includes a connecting shaft fixed to the bottom of the drive shaft, the bottom end of the connecting shaft is provided with a blade, and a baffle is fixedly connected to the inner wall of the tank.

[0012] Preferably, the bottom of the tank is connected to a discharge pipe, and a discharge valve is provided on the outside of the discharge pipe.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] This invention involves pouring the product into the tank from the feeding trough, then adding the nucleic acid remover into the dripping tank through the liquid addition pipe, and opening the flow regulating valve to allow the nucleic acid remover to flow from the connecting pipe into the annular distribution pipe and evenly flow out from several dripping heads to mix with the product. Then, the motor is started to make the driving wheel drive the driven wheel to rotate, thereby causing the drive shaft to drive the connecting shaft to rotate. The connecting shaft synchronously drives the paddle to rotate, thereby stirring the product and the nucleic acid remover, improving the mixing efficiency of the reagent and the product. Attached Figure Description

[0015] Figure 1 A schematic diagram of a preferred embodiment of the standard nucleic acid removal automatic dripping device provided by this utility model;

[0016] Figure 2 This is a partial cross-sectional structural schematic diagram provided for this utility model;

[0017] Figure 3 This is a schematic diagram of the dropping component structure provided by this utility model;

[0018] Figure 4 for Figure 2 Enlarged schematic diagram of the structure at point A in the middle.

[0019] In the diagram: 1. Tank body; 2. Feeding trough; 3. Mixing assembly; 301. Outer shell; 302. Motor; 303. Drive wheel; 304. Driven wheel; 305. Drive shaft; 306. Connecting shaft; 307. Paddle; 308. Baffle plate; 4. Dropping assembly; 401. Dropping tank; 402. Connecting pipe; 403. Annular diverter pipe; 404. Dropping head; 405. Liquid addition pipe; 406. Flow regulating valve; 407. Lifting rod; 5. Discharge pipe. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figures 1-4 As shown, a standard automatic nucleic acid removal agent dripping device includes a tank 1 and a feeding trough 2. The feeding trough 2 is connected to one side of the tank 1, and a mixing component 3 is provided at the center of the top of the tank 1.

[0022] The dripping component 4 is disposed on one side of the top of the tank body 1. The dripping component 4 includes a dripping tank 401 disposed on one side of the top of the tank body 1. A connecting pipe 402 is connected to one side of the dripping tank 401. One end of the connecting pipe 402 penetrates the inner wall of the tank body 1 and is connected to an annular diversion pipe 403.

[0023] The dripping assembly 4 also includes a dripping head 404 connected to the outside of the annular diverter 403. There are several dripping heads 404, which are arranged in a ring.

[0024] The dripping assembly 4 also includes a liquid addition pipe 405 connected to the top of the dripping tank 401, and a flow regulating valve 406 is provided on the outside of the connecting pipe 402.

[0025] The dripping assembly 4 also includes several rods 407 fixed to the top of the annular diverter tube 403. The tops of the rods 407 are fixedly connected to the inner wall of the tank 1. The annular diverter tube 403 can be fixed to the bottom of the inner cavity of the tank 1 through the rods 407.

[0026] The product is poured from the feeding tank 2 into the tank 1. Then, the nucleic acid remover is added from the liquid adding pipe 405 into the dropping tank 401. The flow regulating valve 406 is opened to allow the nucleic acid remover to flow from the connecting pipe 402 into the annular split pipe 403. The nucleic acid remover flows along the annular split pipe 403 and finally flows out evenly from several dropping heads 404 and mixes with the product. Then, the mixing component 3 is started to stir the product and the nucleic acid remover, so that the two can be fully mixed, which improves the mixing efficiency of the reagent and the product.

[0027] The mixing assembly 3 includes a housing 301 fixed to the top of the tank 1. A motor 302 is provided on one side of the housing 301. A drive wheel 303 is fixedly connected to the output end of the motor 302. A driven wheel 304 is meshed with the outer side of the drive wheel 303. A drive shaft 305 is fixedly connected to the inner ring of the driven wheel 304. The top of the drive shaft 305 is rotatably connected to the inner wall of the housing 301 through a bearing seat. The housing 301 is used to protect the two gears.

[0028] The mixing component 3 also includes a connecting shaft 306 fixed to the bottom of the drive shaft 305, with a blade 307 fixedly connected to the bottom end of the connecting shaft 306, and a baffle 308 fixedly connected to the inner wall of the tank 1.

[0029] The bottom of the tank 1 is connected to a discharge pipe 5, and a discharge valve is installed on the outside of the discharge pipe 5.

[0030] The starting motor 302 causes the driving wheel 303 to drive the driven wheel 304 to rotate, which in turn causes the drive shaft 305 to drive the connecting shaft 306 to rotate. The connecting shaft 306 simultaneously drives the paddle 307 to rotate, thereby stirring the products in the tank 1. The baffle 308 can change the flow path of the fluid and increase the turbulence intensity, thereby improving the mixing effect. At the same time, it can break the dead zone of the tank 1, that is, those relatively static areas formed due to rotational force, to ensure that the products and nucleic acid removers can be more evenly distributed and mixed.

[0031] Working principle: The product is poured into the tank 1 from the feeding tank 2. Then, the nucleic acid remover is added into the dripping tank 401 from the liquid adding pipe 405. The flow regulating valve 406 is opened to allow the nucleic acid remover to flow from the connecting pipe 402 into the annular diversion pipe 403. It flows along the annular diversion pipe 403 and finally flows out evenly from several dripping heads 404 and mixes with the product. Then, the motor 302 is started to make the driving wheel 303 drive the driven wheel 304 to rotate, thereby driving the drive shaft 305 to drive the connecting shaft 306 to rotate. The connecting shaft 306 synchronously drives the paddle 307 to rotate, thereby stirring the product and the nucleic acid remover, improving the mixing efficiency of the reagent and the product.

[0032] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0033] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A standard automatic nucleic acid removal agent dispensing device, comprising a tank (1), characterized in that, Also includes: A feeding trough (2) is connected to one side of the tank (1), and a mixing component (3) is provided at the center of the top of the tank (1); A dripping assembly (4) is disposed on one side of the top of the tank (1). The dripping assembly (4) includes a dripping tank (401) disposed on one side of the top of the tank (1). A connecting pipe (402) is connected to one side of the dripping tank (401). One end of the connecting pipe (402) penetrates the inner wall of the tank (1) and is connected to an annular diversion pipe (403).

2. The standard automatic nucleic acid removal agent dosing device according to claim 1, characterized in that: The dripping assembly (4) also includes a dripping head (404) connected to the outside of the annular diverter (403). The number of dripping heads (404) is several, and the several dripping heads (404) are arranged in a ring.

3. The standard automatic nucleic acid removal agent dosing device according to claim 2, characterized in that: The dripping assembly (4) also includes a liquid addition pipe (405) connected to the top of the dripping tank (401), and a flow regulating valve (406) is provided on the outside of the connecting pipe (402).

4. The standard automatic nucleic acid removal agent dosing device according to claim 2, characterized in that: The dripping assembly (4) also includes several rods (407) fixed to the top of the annular diverter (403), and the tops of the rods (407) are fixedly connected to the inner wall of the tank (1).

5. The standard automatic nucleic acid removal agent dosing device according to claim 4, characterized in that: The mixing assembly (3) includes a housing (301) fixed to the top of the tank (1). A motor (302) is provided on one side of the housing (301). A drive wheel (303) is fixedly connected to the output end of the motor (302). A driven wheel (304) is meshed with the outer side of the drive wheel (303). A drive shaft (305) is fixedly connected to the inner ring of the driven wheel (304). The top of the drive shaft (305) is rotatably connected to the inner wall of the housing (301) through a bearing seat.

6. The standard automatic nucleic acid removal agent dosing device according to claim 5, characterized in that: The mixing component (3) also includes a connecting shaft (306) fixed to the bottom of the drive shaft (305), the bottom end of the connecting shaft (306) is provided with a blade (307), and a baffle (308) is fixedly connected to the inner wall of the tank (1).

7. The standard automatic nucleic acid removal agent dosing device according to claim 6, characterized in that: The bottom of the tank (1) is connected to a discharge pipe (5), and a discharge valve is provided on the outside of the discharge pipe (5).

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