Micro-channel reactor

Abstract

The utility model relates to the technical field of allopurinol preparation, and particularly discloses a micro-channel reactor which is characterized in that a hollow mounting ring is arranged in a glass type reactor body, four shunting check rings are arranged in the hollow mounting ring, and a group of comb-tooth-shaped baffles are arranged in each shunting check ring; a reactant is injected into the glass type reactor body along the feeding base, at an inlet of the glass type reactor body, the reactant encounters multiple layers of shunting check rings, a group of comb-tooth-shaped baffles are installed in each shunting check ring, every two of the four comb-tooth-shaped baffles are distributed in a staggered mode, the reactant is shunted into a plurality of fine streams by the first comb-tooth-shaped baffle, and the fine streams are distributed in a staggered mode by the second comb-tooth-shaped baffle. The directions of the streams are changed in the flowing process, then the streams are re-shunted and disorganized on the second-layer comb-tooth-shaped baffle, then the process is repeated, the shunting process is continuously repeated, and in this way, reactants are in full contact and mixed, and good conditions are created for the reaction of allopurinol.

Description

Technical Field

[0001] This invention relates to the field of allopurinol preparation technology, and in particular to a microchannel reactor. Background Technology

[0002] Microchannel reactors are of great significance in the preparation of allopurinol, primarily used for precise control of reaction conditions during the preparation process, thereby improving reaction efficiency and product quality. In practical applications, allopurinol is a key drug for treating diseases such as gout, and its preparation process demands extremely high precision and stability. Microchannel reactors, with their unique structure, can achieve efficient mixing of reactants and precise temperature and pressure control, thus meeting the stringent requirements for reaction conditions in the preparation of allopurinol. They are widely used in the research and production practices of allopurinol in pharmaceutical and chemical manufacturing enterprises and research institutions. Currently, the practical application of microchannel reactors typically requires the following technologies:

[0003] 1. Highly efficient mixing technology ensures that multiple reactants can be rapidly and uniformly mixed in the microchannel during the preparation of allopurinol, creating favorable conditions for the reaction.

[0004] 2. Precise temperature control technology: Since the allopurinol preparation reaction is sensitive to temperature changes, the microchannel reactor needs to be equipped with a high-precision temperature control device.

[0005] 3. Stable pressure control technology ensures stable flow of reactants within the microchannel, preventing pressure fluctuations from affecting the reaction process.

[0006] 4. Corrosion-resistant materials and sealing technology: The reactants and solvents used in the preparation of allopurinol may be corrosive, so the microchannel reactor must be made of corrosion-resistant materials.

[0007] Currently, various microchannel reactors and methods are employed for the preparation of allopurinol. Some companies use glass-based microchannel reactors, creating a microchannel network using photolithography and etching techniques. These glass microchannel reactors offer excellent optical transparency, facilitating observation of the reaction process. During use, reactants are injected into the microchannels via a precision injection pump, utilizing the microstructure within the glass microchannels to achieve mixing and reaction. Other research institutions use stainless steel microchannel reactors, which offer high strength and corrosion resistance. Microchannels are fabricated on stainless steel plates, which are then stacked and sealed to form the reactor. During use, the flow rate and residence time of the reactants within the microchannels are controlled by adjusting the flow rate and pressure of the feed pump. Furthermore, some novel microchannel reactors employ a modular design, combining mixing, reaction, and heat exchange modules, allowing for flexible adjustment of the reactor's structure and function according to different allopurinol preparation process requirements.

[0008] However, the above method has a prominent problem: in the reactant mixing stage, the existing technology mainly relies on the material to be mixed by the flow of the liquid itself after entering the reactor. This mixing method is too passive and lacks effective feed disturbance function. It requires a long flow path to ensure the uniformity of mixing, which prolongs the reaction time and reduces the mixing efficiency. Utility Model Content

[0009] To address the shortcomings of existing technologies, this invention provides a microchannel reactor, which solves the problem that in the reactant mixing stage, existing technologies mainly rely on the material to be mixed by the flow of the liquid itself after entering the reactor. This mixing method is too passive, lacks effective feed disturbance function, and requires a long flow path to ensure the uniformity of mixing, which prolongs the reaction time and reduces the mixing efficiency.

[0010] To achieve the above objectives, this utility model provides the following technical solution:

[0011] A microchannel reactor includes a reaction device body, a feed base inside the reaction device body, a glass reactor body inside the feed base, a hollow mounting ring inside the glass reactor body, four flow-diverting baffles inside the hollow mounting ring, a set of comb-shaped baffles inside each of the four flow-diverting baffles, the four sets of comb-shaped baffles being staggered, and four sets of limiting locking rings fixedly connected inside the hollow mounting ring.

[0012] Preferably, a set of semi-circular snap-fit ​​sleeves is fixedly connected to the outer surface of each of the four diversion baffle rings, and each of the four sets of semi-circular snap-fit ​​sleeves has an arc-shaped through groove inside.

[0013] Preferably, the four sets of arc-shaped through grooves are respectively adapted to the four sets of limiting snap rings, and the hollow mounting ring has a bolt rod connected to its internal thread.

[0014] Preferably, the bolt rod is threaded inside the glass reactor body, and two semi-circular gripping plates are fixedly connected to the upper ends of the four diversion baffles.

[0015] Preferably, the upper ends of the four diverter rings are fixedly connected with directional arrows, which are located between the two semi-circular grips.

[0016] Preferably, a touch screen is provided on the outer surface of the main body of the reaction device, and a glass cover is rotatably connected inside the main body of the reaction device.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. The reactants are injected into the glass reactor body along the feed base. At the inlet of the glass reactor body, the reactants encounter multiple layers of diversion baffles. Each of the four diversion baffles is equipped with a set of comb-shaped baffles, and the four comb-shaped baffles are staggered in pairs. The reactants are diverted into multiple fine streams by the first comb-shaped baffle. These streams change direction during the flow process, and are then diverted and disrupted again by the second layer of comb-shaped baffles. The above process is repeated continuously. In this way, the reactants are fully contacted and mixed, creating favorable conditions for the reaction of allopurinol. The efficient diversion and disturbance path helps to improve the mixing efficiency.

[0019] 2. Hold the semi-circular gripping plate and insert the entire diverter ring into the hollow mounting ring. Align the directional arrow on the upper end of the diverter ring with the direction of the bolt rod. Hold the semi-circular gripping plate and rotate the diverter ring 90 degrees. The diverter ring has a semi-circular snap-fit ​​sleeve with an arc-shaped through groove inside. The arc-shaped through groove and the limiting snap-fit ​​ring are sized to match. The limiting snap-fit ​​ring has a rubber pad attached to its surface. After the diverter ring is rotated 90 degrees, it fits tightly against the surface of the limiting snap-fit ​​ring, thus making it easy and quick to install the diverter ring inside the hollow mounting ring. After rotating it 90 degrees to reset, it can be pulled out. Attached Figure Description

[0020] The above description is only an overview of the technical solution of this utility model. In order to better understand the technical means of this utility model and to implement it in accordance with the contents of the specification, the preferred embodiments of this utility model are described in detail below with reference to the accompanying drawings.

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is an exploded view of the glass reactor body of this utility model.

[0023] Figure 3 This is an exploded view of the hollow mounting ring connection of this utility model;

[0024] Figure 4 This is an exploded view of the flow divider ring connection of this utility model.

[0025] Legend: 11. Main body of the reaction device; 12. Feed base; 13. Glass reactor body; 14. Hollow mounting ring; 15. Diverter ring; 16. Comb-shaped baffle; 17. Limiting snap ring; 18. Semi-circular snap sleeve; 19. Arc-shaped through groove; 21. Bolt rod; 22. Semi-circular grip plate; 23. Directional arrow; 24. Touch screen; 25. Glass cover. Detailed Implementation

[0026] This application provides a microchannel reactor that effectively solves the problem that in the reactant mixing stage, existing technologies mainly rely on the material itself to achieve mixing after entering the reactor. This mixing method is too passive and lacks effective feed disturbance function. It requires a long flow path to ensure the uniformity of mixing, which prolongs the reaction time and reduces the mixing efficiency. The reactants are injected into the glass reactor body along the feed base. At the inlet of the glass reactor body, the reactants encounter multiple layers of diversion baffles. Each of the four diversion baffles is equipped with a set of comb-shaped baffles. The four comb-shaped baffles are staggered in pairs. The reactants are diverted into multiple fine streams by the first comb-shaped baffles. These streams change direction during the flow process and are then diverted and disrupted again by the second layer of comb-shaped baffles. The above process is repeated continuously. In this way, the reactants are fully contacted and mixed, creating favorable conditions for the reaction of allopurinol. The efficient diversion disturbance path helps to improve the mixing efficiency.

[0027] Example

[0028] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the technical solution in this application embodiment effectively solves the problem that in the reactant mixing stage, the existing technology mainly relies on the material to be mixed by the flow of the liquid itself after entering the reactor. This mixing method is too passive and lacks effective feed disturbance function. It requires a long flow path to ensure the uniformity of mixing, which prolongs the reaction time and reduces the mixing efficiency. The overall idea is as follows: A microchannel reactor includes a reaction device body 11, a feed base 12 is arranged inside the reaction device body 11, a glass reactor body 13 is arranged inside the feed base 12, and a hollow mounting ring 14 is arranged inside the glass reactor body 13. The mounting ring 14 has four flow-diverting baffles 15 inside, and each of the four flow-diverting baffles 15 has a set of comb-shaped baffles 16 inside. The four sets of comb-shaped baffles 16 are staggered. When the reactants encounter the multiple layers of flow-diverting baffles 15, each of the four flow-diverting baffles 15 has a set of comb-shaped baffles 16 installed inside. The four comb-shaped baffles 16 are staggered in pairs. The reactants are diverted into multiple fine streams by the first comb-shaped baffle 16. These streams change direction during the flow process, and are then diverted and disrupted again by the second layer of comb-shaped baffles 16. The above process is repeated continuously. In this way, the reactants are fully contacted and mixed, creating favorable conditions for the reaction of allopurinol.

[0029] The hollow mounting ring 14 is internally fixedly connected to four sets of limiting snap rings 17. The outer surfaces of the four diversion baffles 15 are each fixedly connected to a set of semi-circular snap sleeves 18. The four sets of semi-circular snap sleeves 18 are each provided with an arc-shaped through groove 19. The four sets of arc-shaped through grooves 19 are respectively adapted to the four sets of limiting snap rings 17. The hollow mounting ring 14 is internally threaded with a bolt rod 21. The bolt rod 21 is threadedly connected to the inside of the glass reactor body 13. The reactants prepared by allopurinol are transported to the feed base 12 through a hose connected to a pipeline. The reactants are injected into the glass reactor body 13 along the feed base 12. At the inlet of the glass reactor body 13, the hollow mounting ring 14 is fixed by screwing on the bolt rod 21. The bolt rod 21 is not directly screwed into the glass reactor body 13. The glass reactor body 13 is equipped with a metal reinforcing bushing. The reinforcing bushing has an internal threaded groove. The bolt rod 21 is threadedly screwed into the inside of the reinforcing bushing.

[0030] Four flow divider rings 15 are fixedly connected to the upper ends of two semi-circular grip plates 22, and four flow divider rings 15 are fixedly connected to the upper ends of directional arrows 23, which are located between the two semi-circular grip plates 22. A touch screen 24 is provided on the outer surface of the main body 11 of the reaction device. A glass cover 25 is rotatably connected inside the main body 11 of the reaction device. The reactants required for the preparation of allopurinol are injected into the feed base 12 through an injection pump and a tubing. The reactants are injected into the glass reactor body 13 along the feed base 12. An S-shaped flow channel is opened in the glass reactor body 13. The allopurinol reactants react during the flow in the S-shaped flow channel. Allopurinol is generated. By adjusting the flow rate of the injection pump, the reactants are allowed to remain in the microchannel for a certain period of time to achieve the optimal reaction conversion rate and product selectivity. After the reaction is completed, the allopurinol material flows out of the glass reactor body 13. The outlet of the glass reactor body 13 is connected to the subsequent processing equipment to prepare for subsequent extraction and purification operations. The touch screen 24 installed on the surface of the reaction device body 11 can be adjusted by touch to control the injection speed of the injection pump. The rotating glass cover 25 inside the reaction device body 11 is made of glass and can be closed by screwing to form a closed space to protect the glass reactor body 13.

[0031] To address the problems existing in the prior art, this utility model provides a microchannel reactor. The reactants are injected into the glass reactor body 13 along the feed base 12. At the inlet of the glass reactor body 13, the reactants encounter multiple layers of diversion baffles 15. Each of the four diversion baffles 15 is equipped with a set of comb-shaped baffles 16. The four comb-shaped baffles 16 are staggered in pairs. The reactants are diverted into multiple fine streams by the first comb-shaped baffles 16. These streams change direction during the flow process and are then diverted and disrupted again by the second layer of comb-shaped baffles 16. The above process is repeated continuously. In this way, the reactants are fully contacted and mixed, creating favorable conditions for the reaction of allopurinol. The efficient diversion and disturbance path is beneficial to improving the mixing efficiency.

[0032] The main body of the reaction device 11 serves as the basic framework of the entire microchannel reactor, supporting and accommodating other components, and providing a stable platform for the installation and coordinated operation of each component.

[0033] Feed base 12: It serves to receive and guide the reactants. The reactants required for the preparation of allopurinol are transported to the feed base 12 through a hose connected to the pipeline, and then injected into the glass reactor body 13 along it, providing a material input channel for the reaction and ensuring that the reactants can smoothly enter the reaction area.

[0034] The glass reactor body 13: The internal structure includes a hollow mounting ring 14 and an S-shaped flow channel, which is the core site where the allopurinol reaction occurs.

[0035] Hollow mounting ring 14: Four sets of limiting snap rings 17 are fixedly connected inside, which cooperate with the semi-circular snap sleeves 18 on the outer surface of the diversion baffle ring 15 to realize the convenient installation and fixation of the diversion baffle ring 15 in the hollow mounting ring 14, ensuring the stable position of the diversion baffle ring 15 during the reaction process, thereby ensuring the diversion and mixing effect of the reactants.

[0036] Flow divider 15: When the reactants enter the inlet of the glass reactor body 13 and encounter the multi-layer flow divider 15, the comb-shaped baffles 16 inside divide the reactants, causing the reactants to be divided into multiple fine streams. By continuously repeating the flow divider process, the contact area between the reactants is greatly increased, the mixing effect is enhanced, and good conditions are created for the allopurinol reaction.

[0037] Comb-shaped baffle 16: When the reactants encounter the comb-shaped baffle 16, they are diverted into multiple fine streams by the first comb-shaped baffle 16. These streams change direction during the flow process and are then diverted and disrupted again by the second comb-shaped baffle 16. This diversion process is repeated continuously, which promotes full contact and mixing between the reactants, improves the mixing efficiency, and plays a key role in the efficient conduct of the allopurinol reaction.

[0038] Limiting retaining ring 17: When installing the diversion retaining ring 15, after the diversion retaining ring 15 is turned 90 degrees, the arc groove 19 fits tightly with the limiting retaining ring 17, restricting the rotation and displacement of the diversion retaining ring 15, ensuring the stability of the diversion retaining ring 15 in the hollow mounting ring 14, thereby ensuring the stability and continuity of reactant diversion and mixing.

[0039] Semi-circular snap-fit ​​sleeve 18: It cooperates with the limiting snap-fit ​​ring 17 inside the hollow mounting ring 14 to realize the quick installation and fixation of the diversion baffle ring 15 inside the hollow mounting ring 14. Through the tight connection with the limiting snap-fit ​​ring 17, the positional accuracy of the diversion baffle ring 15 in the reaction process is ensured, so that the comb-shaped baffle 16 can continuously and effectively divert and mix the reactants.

[0040] Arc-shaped through groove 19: When installing the flow divider ring 15, turn the flow divider ring 15 ninety degrees so that the arc-shaped through groove 19 fits tightly with the limiting snap ring 17, so as to achieve a stable connection between the flow divider ring 15 and the hollow mounting ring 14, ensuring that the flow divider ring 15 will not loosen during the reaction process and maintaining the stability of the reactant flow divider mixing structure.

[0041] Bolt rod 21: Threaded connection inside the hollow mounting ring 14 and inside the metal reinforcing bushing of the glass reactor body 13. By tightening the bolt rod 21, the hollow mounting ring 14 is fixed at the inlet of the glass reactor body 13.

[0042] Semi-circular grip plate 22: Convenient for operators to hold. When installing the diverter ring 15, the operator holds the surface of the semi-circular grip plate 22 and inserts the diverter ring 15 into the hollow mounting ring 14 as a whole, and then turns it 90 degrees to complete the installation, or turns it 90 degrees to reset and then pulls it outward, which facilitates the installation, disassembly and maintenance of the diverter ring 15.

[0043] Pointing arrow 23: When installing the diversion baffle ring 15, it is used to align the bolt rod 21, providing the operator with an installation direction indicator to ensure that the diversion baffle ring 15 is accurately installed in the hollow mounting ring 14, ensuring the fitting accuracy of the diversion baffle ring 15 with other components, so that the diversion and mixing process of the reactants can proceed normally;

[0044] Touch screen 24: Operators can adjust the injection speed of the injection pump by touching the touch screen 24, thereby controlling the flow rate of reactants into the feed base 12, realizing precise control of the residence time of reactants in the microchannel, so as to achieve the best reaction conversion rate and product selectivity, and facilitating real-time control of the reaction process.

[0045] Glass cover 25: It can be closed by screwing to form a closed space to shield and protect the glass reactor body 13, preventing external factors from interfering with the reaction process. At the same time, the glass material makes it easy to observe the reaction inside the glass reactor body 13, ensuring the safe conduct of the reaction while meeting the operator's needs for observing the reaction process.

[0046] Working principle:

[0047] In the first step, the reactants required for allopurinol preparation are injected into the feed base 12 via an injection pump and tubing. The reactants are then injected into the glass reactor body 13 along the feed base 12. An S-shaped flow channel is opened inside the glass reactor body 13. The allopurinol reactants react to form allopurinol during the flow within the S-shaped flow channel. By adjusting the flow rate of the injection pump, the reactants are allowed to remain in the microchannel for a certain period of time to achieve the optimal reaction conversion rate and product selectivity. After the reaction is completed, the allopurinol material flows out of the glass reactor body 13. The outlet of the glass reactor body 13 is connected to subsequent processing equipment to prepare for subsequent extraction and purification operations. The touch screen 24 installed on the surface of the reaction device body 11 can be adjusted by touch to control the injection speed of the injection pump. The rotating glass cover 25 inside the reaction device body 11 is made of glass and can be closed by screwing to form a closed space to protect the glass reactor body 13.

[0048] In the second step, the allopurinol reactants are transported to the feed base 12 via a hose connected to a pipeline. The reactants are then injected into the glass reactor body 13 along the feed base 12. At the inlet of the glass reactor body 13, a hollow mounting ring 14 is fixed by a screw rod 21. The screw rod 21 is not directly screwed into the glass reactor body 13; the glass reactor body 13 is fitted with a metal reinforcing bushing with an internal threaded groove. The screw rod 21 is threaded and installed inside the reinforcing bushing. The reactants encounter multiple layers of diversion baffles 15. Each of the four diversion baffles 15 contains a set of comb-shaped baffles 16, with each pair of comb-shaped baffles 16 staggered. The reactants are diverted into multiple fine streams by the first comb-shaped baffle 16. These streams change direction during flow and are then re-diverted and disrupted by the second layer of comb-shaped baffles 16, repeating the above process continuously. This diversion process is repeated continuously. In this way, the reactants are fully contacted and mixed, creating favorable conditions for the reaction of allopurinol. When installing the flow divider rings 15, firstly, the four flow divider rings 15 are installed together by adhesive bonding. Then, holding the surface of the semi-circular gripper 22, the flow divider rings 15 are inserted entirely into the hollow mounting ring 14. The directional arrow 23 installed on the upper end of the flow divider ring 15 should be aligned with the direction of the bolt rod 21. Holding the surface of the semi-circular gripper 22, the flow divider rings 15... Twist it 90 degrees, and a semi-circular snap-fit ​​sleeve 18 is installed on the surface of the diverter ring 15. An arc-shaped through groove 19 is opened in the semi-circular snap-fit ​​sleeve 18. The arc-shaped through groove 19 and the limiting snap-fit ​​ring 17 are matched in size. A rubber pad is glued to the surface of the limiting snap-fit ​​ring 17. After the diverter ring 15 is twisted 90 degrees, it fits tightly with the surface of the limiting snap-fit ​​ring 17, so that the diverter ring 15 can be installed in the hollow mounting ring 14 conveniently and quickly. After twisting it 90 degrees to reset it, it can be pulled out.

[0049] Finally, it should be noted that the above embodiments are merely examples for clearly illustrating the present invention and are not intended to limit the implementation. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.

Claims

1. A microchannel reactor, comprising a reaction device body (11), wherein a feed base (12) is disposed inside the reaction device body (11), characterized in that, The feed base (12) is provided with a glass reactor body (13), the glass reactor body (13) is provided with a hollow mounting ring (14), the hollow mounting ring (14) is provided with four flow-diverting baffles (15), and each of the four flow-diverting baffles (15) is provided with a set of comb-shaped baffles (16), and the four sets of comb-shaped baffles (16) are staggered. The hollow mounting ring (14) is internally fixedly connected with four sets of limiting locking rings (17).

2. A microchannel reactor as described in claim 1, characterized in that, A set of semi-circular snap-fit ​​sleeves (18) are fixedly connected to the outer surface of each of the four diversion retaining rings (15); Among them, the four sets of semi-circular snap sleeves (18) are all provided with arc-shaped through grooves (19).

3. A microchannel reactor as described in claim 2, characterized in that, The four sets of circular arc through grooves (19) are respectively adapted to the four sets of limiting locking rings (17); The hollow mounting ring (14) has a bolt rod (21) internally threaded.

4. A microchannel reactor as described in claim 3, characterized in that, The bolt rod (21) is threaded inside the glass reactor body (13); Among them, two semi-circular gripping plates (22) are fixedly connected to the upper ends of the four diversion baffles (15).

5. A microchannel reactor as described in claim 4, characterized in that, The upper ends of the four diversion baffles (15) are fixedly connected with directional arrows (23); The pointing arrow (23) is located between the two semi-circular grips (22).

6. A microchannel reactor as described in claim 5, characterized in that, The outer surface of the main body (11) of the reaction device is provided with a touch screen (24); The reaction device body (11) is rotatably connected to a glass cover (25).

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