Pharmaceutical reaction kettle
By integrating a heat exchange hood into the reactor, the problem of uneven temperature gradient was solved, achieving smooth transition of hot and cold alternation and temperature gradient, thereby improving the stability of the microbial fermentation environment and the quality of pharmaceutical products.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- NANTONG HUADA PHARM EQUIP TECH CO LTD
- Filing Date
- 2025-04-21
- Publication Date
- 2026-05-15
AI Technical Summary
The existing pharmaceutical reactors have an independent operation of the bottom heater of the inner tank and the cooling coil of the outer wall, which leads to uneven temperature gradient distribution, affecting the stability of the microbial fermentation environment and the quality of the finished product.
An integrated heat exchange hood is adopted, which integrates heating and cooling functions into the same structure. The switching between the inner and outer cavities achieves alternation of hot and cold and smooth transition of temperature gradient. The design of the inner and outer vessel layers reduces the heat exchange path and avoids excessive internal temperature difference.
It improves the stability of the microbial fermentation environment and the quality of the finished product, enables precise control of the pharmaceutical process, and enhances product quality.
Smart Images
Figure CN224243049U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of pharmaceutical technology, and in particular to a pharmaceutical reaction vessel. Background Technology
[0002] Reactors are widely used in the food, pharmaceutical, and chemical industries, and people are familiar with their structure. However, current drug preparation methods require the addition of microorganisms, which ferment inside the reactor.
[0003] Existing patent CN208266186U provides a pharmaceutical reaction vessel conducive to microbial fermentation, comprising a base, a DSP controller embedded in the front of the base, an outer vessel fixedly mounted above the base, an inner vessel inside the outer vessel, a heater between the bottom of the inner vessel and the base, a motor above the top cover, the motor's output shaft passing through the top cover and fixedly connected to a rotating shaft, threaded blocks fixedly connected to both sides of the rotating shaft, a stirring shaft connected to the threaded blocks, the stirring shaft located inside the inner vessel, a cooling coil wound around the outer wall of the inner vessel, a temperature sensor, an oxygen sensor, and a pressure sensor installed on the inner wall of the inner vessel, a discharge pipe fixedly connected to the bottom of the inner vessel, and an observation window hinged to the front of the outer vessel. This utility model provides the necessary environment for microbial fermentation, has a reasonable structure, practical function, is easy to move, and is suitable for widespread application.
[0004] However, the above structure has the following drawbacks in practical application: the heater at the bottom of the inner tank and the cooling coil on the outer wall operate independently, which may lead to uneven temperature gradient distribution, affecting the stability of the microbial fermentation environment and the quality of the finished product. Utility Model Content
[0005] The technical problem to be solved by this utility model is to provide a pharmaceutical reaction vessel.
[0006] To solve the above-mentioned technical problems, the technical solution of this utility model is: a pharmaceutical reaction vessel, the innovation of which lies in: including
[0007] Outer vessel body;
[0008] Top cover, which is disposed on top of the outer vessel body;
[0009] An inner vessel body, wherein the inner vessel body is disposed inside the outer vessel body;
[0010] A heat exchange hood is disposed between the inner vessel body and the outer vessel body, and is detachably connected to the upper vessel body;
[0011] The heat exchange hood includes a tubular body disposed in the middle of the outer side of the inner vessel body. The height of the tubular body is h1, and the height of the inner vessel body is h2. h1 = (4 / 5~1) * h2. The tubular body has an annular inner cavity and an annular outer cavity that are not interconnected.
[0012] The upper section of the vessel body is also provided with an internal heating pipe, an internal heat exchange pipe, an external cooling pipe, an internal drain pipe, and an external drain pipe. The water inlet end of the internal heating pipe is connected to a heating tank, the two water inlets of the internal heat exchange pipe are respectively connected to the heating tank and a cooling tank, and the water inlet end of the external cooling pipe is connected to the cooling tank.
[0013] The water outlet of the inner heating pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity; the water outlet of the inner heat exchange pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity; the water outlet of the outer cooling pipe passes through the outer vessel body and is connected to the outer cavity.
[0014] The inlet end of the inner drain pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity, and the inlet end of the outer drain pipe passes through the outer vessel body and is connected to the outer cavity.
[0015] Furthermore, the outer vessel body includes an upper vessel body and a lower vessel body, and both the upper and lower vessel bodies are fixedly equipped with connecting flanges. When it is necessary to replace the heat exchange hood or perform routine maintenance, the lower vessel body can be separated from the upper vessel body through the connecting flanges, and then the lower vessel body can be lowered to expose the internal structure.
[0016] The inner layer of the vessel body is fixedly connected to the lower section of the vessel body;
[0017] The water outlet of the inner heating pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The water outlet of the inner heat exchange pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The water outlet of the outer cooling pipe passes through the upper section of the vessel body and is connected to the outer cavity.
[0018] The inlet end of the inner drain pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The inlet end of the outer drain pipe passes through the upper section of the vessel body and is connected to the outer cavity.
[0019] Furthermore, a limiting ring column is provided on the inner wall of the lower section of the vessel, and a circular limiting groove is provided at the top of the limiting ring column. A circular limiting block is provided at the bottom of the heat exchange hood, and the circular limiting block is just placed in the circular limiting groove.
[0020] Furthermore, the cross-section of the annular limiting groove is an inverted isosceles trapezoid shape, which improves the installation stability of the heat exchange cover during the use of this structure.
[0021] Furthermore, the outer vessel body is also equipped with a temperature sensor and a pressure sensor, which monitor the internal temperature and pressure of the inner vessel body in real time, thereby achieving precise control in the pharmaceutical process and improving the quality of pharmaceuticals.
[0022] Furthermore, the inner vessel is cylindrical, with a downwardly sloping transition surface on the inner side of its top. The outer vessel has a groove inside that accommodates the outer side of the top of the inner vessel, and a sealing strip is provided in the groove. The sealing strip prevents liquid inside the inner vessel from flowing into the groove from the outer side of the top of the inner vessel, thus avoiding contamination between the inner and outer vessels.
[0023] The advantages of this utility model are:
[0024] In this structure, heating and cooling functions are integrated into the same structure using a heat exchange hood. By switching between the inner and outer cavities, hot and cold alternation and smooth transition of temperature gradient are achieved, reducing the heat exchange path, avoiding excessive temperature difference between the outer wall and the inside of the tank, improving the stability of the microbial fermentation environment and the quality of the finished product.
[0025] The outer vessel body includes an upper vessel body and a lower vessel body, and both the upper and lower vessel bodies are fixedly equipped with connecting flanges. When it is necessary to replace the heat exchange hood or perform routine maintenance, the lower vessel body can be separated from the upper vessel body through the connecting flanges, and then the lower vessel body can be lowered to expose the internal structure.
[0026] The cross-section of the annular limiting groove is an inverted isosceles trapezoid, which improves the installation stability of the heat exchange hood during the use of this structure.
[0027] The outer vessel is also equipped with temperature and pressure sensors, which monitor the internal temperature and pressure of the inner vessel in real time, enabling precise control during the pharmaceutical process and improving the quality of the pharmaceutical products.
[0028] The inner vessel is cylindrical, with a downward-sloping transition surface on the inner side of its top. The outer vessel has a groove inside that accommodates the outer side of the top of the inner vessel, and a sealing strip is installed in the groove. The sealing strip prevents liquid inside the inner vessel from flowing into the groove from the outer side of the top of the inner vessel, thus avoiding contamination between the inner and outer vessels. Attached Figure Description
[0029] Figure 1 This is the front view of the present invention.
[0030] Figure 2 A cross-sectional view of this utility model Figure 1 .
[0031] Figure 3A cross-sectional view of this utility model Figure 2 .
[0032] Figure 4 This is a partial view of the present invention. Detailed Implementation
[0033] To further illustrate the technical means and effects adopted by this utility model in order to achieve the intended utility model purpose, the following detailed description of the specific implementation methods, structure, features and effects of this utility model is provided in conjunction with the accompanying drawings and preferred embodiments.
[0034] like Figure 1-4 The pharmaceutical reaction vessel shown includes an outer vessel body 1, a top cover 2, an inner vessel body 3, a heat exchange hood 4, and a stirrer 9.
[0035] The outer vessel body 1 includes an upper vessel body 11 and a lower vessel body 12, and both the upper vessel body 11 and the lower vessel body 12 are fixedly equipped with connecting flanges. When it is necessary to replace the heat exchange shroud 4 or to perform routine maintenance, the lower vessel body 12 can be separated from the upper vessel body 11 through the connecting flanges, and then the lower vessel body 12 can be lowered to expose the internal structure.
[0036] The top cover 2 is located on top of the outer vessel body 1.
[0037] The inner vessel body 3 is located inside the outer vessel body 1, and the inner vessel body 3 is fixedly connected to the lower vessel body 12.
[0038] The heat exchange shroud 4 is located between the inner vessel body 3 and the outer vessel body 1, and is detachably connected to the upper vessel body 11.
[0039] Multiple snap-fit blocks 5 are provided on the outer vessel body 1. These snap-fit blocks 5 pass through the outer vessel body 1 and snap into the outside of the heat exchange shroud 4.
[0040] The heat exchange shroud 4 includes a tubular body 41 located in the middle of the outer side of the inner vessel 3. The height of the tubular body 41 is h1, and the height of the inner vessel 3 is h2. h1 = (4 / 5~1) * h2, ensuring the contact area and heat exchange effect between the heat exchange shroud 4 and the inner vessel 3. The tubular body 41 has an annular inner cavity 42 and an annular outer cavity 43 that are not interconnected.
[0041] The upper section of the vessel body 11 is also equipped with an internal heating pipe, an internal heat exchange pipe, an external cooling pipe, an internal drain pipe, and an external drain pipe. The water inlet end of the internal heating pipe is connected to a heating tank, the two water inlets of the internal heat exchange pipe are connected to the heating tank and a cooling tank respectively, and the water inlet end of the external cooling pipe is connected to the cooling tank.
[0042] The outlet of the inner heating pipe is located at the top of the upper section of the vessel 11, and it passes through the upper section of the vessel 11 and the outer cavity 43 before communicating with the top of the inner cavity 42.
[0043] The water outlet of the internal heat exchange tube is located at the bottom of the upper section of the vessel 11, and it passes through the upper section of the vessel 11 and the outer cavity 43 and is connected to the bottom of the inner cavity 42.
[0044] The outlets of the internal heat exchanger and the internal heating pipe are located at the top and bottom respectively, staggered to achieve a smooth transition of the temperature gradient.
[0045] The water outlet of the external cooling pipe is located at the top of the upper section of the vessel 11, and it is connected to the top of the outer cavity 43 after passing through the upper section of the vessel 11.
[0046] The inlet end of the inner drain pipe passes through the upper section of the vessel body 11 and the outer cavity 43 and is connected to the inner cavity 42. The inlet end of the outer drain pipe passes through the upper section of the vessel body 11 and is connected to the outer cavity 43.
[0047] A limiting ring post 6 is also provided on the inner wall of the lower section of the vessel body 12. A circular limiting groove is opened at the top of the limiting ring post 6, and a circular limiting block 7 is provided at the bottom of the heat exchange hood body 4. The circular limiting block 7 is just set in the circular limiting groove.
[0048] The cross-section of the annular limiting groove is an inverted isosceles trapezoid shape, which improves the installation stability of the heat exchange cover 4 during the use of this structure.
[0049] The outer vessel 1 is also equipped with a temperature sensor and a pressure sensor. The temperature sensor and pressure sensor monitor the internal temperature and pressure of the inner vessel 3 respectively, and monitor in real time to achieve precise control in the pharmaceutical process and improve the quality of pharmaceuticals.
[0050] The inner vessel 3 is cylindrical, with its top opening as the inlet and its bottom opening as the outlet. It is connected to the bottom outlet of the lower section of the outer vessel 1 1. The inner vessel 3 has a downwardly sloping transition surface 8 on its top inner side and a horizontal surface on its top outer side. The outer vessel 1 has a groove inside that can accommodate the outer surface of the top of the inner vessel 3. A sealing strip is also provided in the groove to seal the horizontal surface of the top outer side of the inner vessel 3. The sealing strip prevents the liquid inside the inner vessel from flowing into the groove from the outer surface of the top of the inner vessel 3, thus avoiding contamination between the inner vessel 3 and the outer vessel 1.
[0051] The working principle of this patent:
[0052] Open the top cover 2, and the material enters the inner layer of the vessel 3 through the feed inlet. The material can be stirred using a stirrer. When the inner layer of the vessel 3 needs to be heated, the heating medium inside the heating tank enters the inner cavity of the heat exchange hood 4 through the inner heating pipe. When the temperature sensor detects that the temperature inside the inner layer of the vessel 3 is too high, the cooling medium inside the cooling tank is sent into the outer cavity through the outer cooling pipe to achieve a smooth transition of the temperature inside the inner layer of the vessel 3. At the same time, the cooling medium can also be sent into the inner cavity through the inner heat exchange pipe for auxiliary cooling. The processed material is discharged from the discharge port of the inner layer of the vessel 3 and the bottom discharge port of the lower vessel 12.
[0053] In this structure, heating and cooling functions are integrated into the same heat exchange hood 4, which realizes the smooth transition of hot and cold alternation and temperature gradient, reduces the heat exchange path, avoids excessive temperature difference between the outer wall and the inside of the tank, improves the stability of the microbial fermentation environment, and enhances the quality of the finished product.
[0054] When it is necessary to replace the heat exchange shroud or perform routine maintenance, the lower section of the vessel can be separated from the upper section through the connecting flange, and then the lower section of the vessel can be lowered to expose the internal structure.
[0055] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present utility model. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.
Claims
1. A pharmaceutical reaction vessel, characterized in that: include Outer vessel body; Top cover, which is disposed on top of the outer vessel body; An inner vessel body, wherein the inner vessel body is disposed inside the outer vessel body; A heat exchange hood is disposed between the inner vessel body and the outer vessel body, and is detachably connected to the upper vessel body. The heat exchange hood includes a tubular body disposed in the middle of the outer side of the inner vessel body. The height of the tubular body is h1, and the height of the inner vessel body is h2. h1 = (4 / 5~1) * h2. The tubular body has an annular inner cavity and an annular outer cavity that are not interconnected. The upper section of the vessel body is also provided with an internal heating pipe, an internal heat exchange pipe, an external cooling pipe, an internal drain pipe, and an external drain pipe. The water inlet end of the internal heating pipe is connected to a heating tank, the two water inlets of the internal heat exchange pipe are respectively connected to the heating tank and a cooling tank, and the water inlet end of the external cooling pipe is connected to the cooling tank. The water outlet of the inner heat pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity; the water outlet of the inner heat exchange pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity; the water outlet of the outer cold pipe passes through the outer vessel body and is connected to the outer cavity. The inlet end of the inner drain pipe passes through the outer vessel body and the outer cavity and is connected to the inner cavity, and the inlet end of the outer drain pipe passes through the outer vessel body and is connected to the outer cavity.
2. The pharmaceutical reaction vessel according to claim 1, characterized in that: The outer vessel body includes an upper vessel body and a lower vessel body, and a connecting flange is fixedly installed on both the upper vessel body and the lower vessel body; The inner layer of the vessel body is fixedly connected to the lower section of the vessel body; The water outlet of the internal heat pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The water outlet of the internal heat exchange pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The water outlet of the external cold pipe passes through the upper section of the vessel body and is connected to the outer cavity. The inlet end of the inner drain pipe passes through the upper section of the vessel body and the outer cavity and is connected to the inner cavity. The inlet end of the outer drain pipe passes through the upper section of the vessel body and is connected to the outer cavity.
3. A pharmaceutical reaction vessel according to claim 2, characterized in that: A limiting ring column is also provided on the inner wall of the lower section of the vessel. A circular limiting groove is opened at the top of the limiting ring column, and a circular limiting block is provided at the bottom of the heat exchange hood. The circular limiting block is just placed in the circular limiting groove.
4. A pharmaceutical reaction vessel according to claim 3, characterized in that: The cross-section of the annular limiting groove is an inverted isosceles trapezoid shape.
5. A pharmaceutical reaction vessel according to claim 1, characterized in that: The outer vessel body is also equipped with a temperature sensor and a pressure sensor.
6. A pharmaceutical reaction vessel according to claim 2, characterized in that: The inner vessel is cylindrical, with a downwardly sloping transition surface on the inner side of its top. The outer vessel has a groove inside that accommodates the outer side of the top of the inner vessel, and a sealing strip is provided in the groove.