Intelligent monitoring and identifying cell culture device

Abstract

The utility model belongs to the technical field of cell culture, and particularly relates to an intelligent monitoring and identifying cell culture device which comprises a culture frame, a plurality of relatively independent culture bins are arranged on the culture frame, a culture box is arranged in each culture bin, and the culture boxes can enter and exit from the culture bins; the transfer trolley can bear the culture box and transport the culture box between the culture frame and other processes; the control device is arranged beside the culture frame and is used for controlling the culture environment of the culture box; and the recognition device is arranged on the culture frame, and the recognition device can recognize the culture boxes transported to the culture frame by the transfer trolley and input information. The transfer trolley is arranged to bear the culture box and transport the culture box between the culture frame and other processes, labor can be reduced, efficiency can be improved, the problem of secondary pollution can be effectively avoided, the recognition device is arranged, each cell box can be put in storage, recognized and input information, and the culture environment can be specifically adjusted through the control device.

Description

Technical Field

[0001] This invention belongs to the field of cell culture technology, and in particular relates to an intelligent monitoring and identification device for cell culture. Background Technology

[0002] A cell factory is a cell culture device that maximizes the culture surface area within a limited space, thus saving space. It can be used for industrial-scale production of cells such as vaccines, monoclonal antibodies, or biopharmaceuticals, and is particularly suitable for adherent cells. It can also be used for suspension culture. Furthermore, it does not alter the cell growth kinetics when scaling up from laboratory scale, making scale-up simple and easy, with low contamination risk and space savings. The cell culture device is a crucial component of a cell factory.

[0003] For example, CN222758250U discloses an easily stackable cell culture device. Its technical solution includes: a base, with a battery internally disposed; a first connecting seat fixedly disposed on the upper surface of the base, electrically connected to the battery; a set of support rods disposed on the upper surface of the base, with multiple culture components for cell culture disposed between the support rods, sleeves fixedly disposed on both sides of each culture component, the sleeves movably engaging with the support rods; a sealing component located at the upper end of the culture component for sealing it; and a limiting component disposed inside the support rods for limiting the position of the culture components. This invention enables more stable stacking of culture dishes, preventing slippage or tilting during stacking, and also preventing collisions and damage during stacking, thus avoiding leakage of cell culture medium and loss of cells.

[0004] The aforementioned cell culture device still requires manual placement and culture, which is inefficient. Furthermore, improper manual operation can easily contaminate the cell culture device. In addition, there is no identification system, making it impossible to individually identify, specifically control, and operate each cell culture component. Utility Model Content

[0005] The purpose of this invention is to provide an intelligent monitoring and identification cell culture device, which aims to solve the technical problems mentioned above, namely that "the existing cell culture device still requires manual placement and culture, which is inefficient and can easily contaminate the cell culture device if the manual operation is improper. At the same time, there is no identification system, so it is impossible to identify each cell culture component individually and control and operate it in a specific way".

[0006] To achieve the above objectives, this utility model provides an intelligent monitoring and identification cell culture device, comprising: a culture rack with multiple relatively independent culture chambers, each culture chamber containing a culture box, the culture box being able to enter and exit the culture chamber; a transfer trolley capable of carrying the culture box and transporting it between the culture rack and other processes; a control device located next to the culture rack and controlling the culture environment of the culture box; and an identification device located on the culture rack, capable of identifying and recording information about the culture box transported to the culture rack by the transfer trolley.

[0007] Optionally, the identification device includes an identification detector and a first moving device; the identification detector is disposed on the first moving device, and the first moving device can drive the identification detector to move left and right on the top of the culture rack to identify the incubator.

[0008] Optionally, each culture chamber is provided with multiple connection ports for connecting the control device, and one side of the culture chamber is provided with an adapter corresponding to the connection port, and the connection port and the adapter can be matched and connected accordingly.

[0009] Optionally, the transfer trolley includes a main body; the main body is provided with a liftable support plate, which is used to support the incubator.

[0010] Optionally, guide rails are provided on both the support plate and the bottom of the culture chamber, and a pulley assembly is provided at the bottom of the culture box. The culture box can be moved from the culture chamber to the required process by sliding.

[0011] Optionally, the control device further includes a display screen with operation buttons that can adjust various parameters.

[0012] Optionally, the incubator is provided with a culture dish, the culture dish including multiple stacked culture chambers, and each culture chamber is independent of the others. The culture dish is provided with a channel, and each culture chamber is provided with a through hole communicating with the channel. The opening of the channel is provided with a lid for closing.

[0013] Optionally, the incubator has an opening connecting to the outside, and a second moving device is provided inside the incubator. The second moving device has a moving plate, and the petri dish is placed on the moving plate. The moving plate can extend out of or retract into the incubator from the opening via the second moving device.

[0014] Furthermore, the opening is also provided with an openable and closable cover.

[0015] Furthermore, it also includes multiple culture environment material tanks, which are connected to the connection port via pipes.

[0016] Compared with the prior art, the above-mentioned one or more technical solutions in the intelligent monitoring and identification cell culture device provided by the present invention have at least one of the following technical effects:

[0017] By setting up a transfer trolley to carry the incubators and transport them between the culture rack and other processes, manual labor can be reduced, efficiency can be increased, and the problem of secondary contamination can be effectively avoided. By setting up an identification device, information can be entered and identified for each cell box upon entry. The culture environment can be adjusted in a specific way through the control device. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of this utility model.

[0020] Figure 2 This is a partial structural schematic diagram of the present invention.

[0021] Figure 3 This is a schematic diagram of the incubator structure.

[0022] Figure 4 This is a schematic diagram of the incubator from another angle.

[0023] Figure 5 This is a schematic diagram of the cross-sectional structure of the incubator.

[0024] The following are the labeling elements in the figure:

[0025] 100. Culture rack; 110. Culture chamber; 120. Connection port; 130. Raw material tank for culture environment;

[0026] 200. Incubator; 210. Adapter; 220. Petri dish; 221. Culture chamber; 222. Channel; 223. Through hole; 224. Lid; 230. Opening; 240. Moving plate; 250. Cover body; 260. Pulley assembly;

[0027] 300. Transfer trolley; 310. Body; 320. Support plate; 330. Guide rail;

[0028] 400. Control device; 410. Display screen; 420. Operation buttons;

[0029] 500, Identification device; 510, Identification detector; 520, First moving device. Detailed Implementation

[0030] The embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the embodiments of the present invention, and should not be construed as limiting the present invention.

[0031] In the description of the embodiments of this utility model, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing the embodiments of this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0032] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of embodiments of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0033] In this embodiment of the invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this embodiment of the invention according to the specific circumstances.

[0034] In one embodiment of this utility model, according to Figure 1-5As shown, it includes: a culture rack 100, on which multiple relatively independent culture chambers 110 are provided, each culture chamber 110 containing an incubator 200, which can enter and exit the culture chamber 110; a transfer trolley 300, which can carry the incubator 200 and transport it between the culture rack 100 and other processes; a control device 400, which is located next to the culture rack 100 and controls the culture environment of the incubator 200; and an identification device 500, which is located on the culture rack 100 and can identify and record information of the incubator 200 transported to the culture rack 100 by the transfer trolley 300.

[0035] Specifically, by setting up a transfer trolley 300 to carry the incubator 200 and transport it between the culture rack 100 and other processes, manual labor can be reduced, efficiency can be increased, and the problem of secondary contamination can be effectively avoided. By setting up an identification device 500, information can be entered and identified for each cell box. The culture environment can be adjusted in a specific way through the control device 400.

[0036] In another embodiment of this utility model, according to Figure 1 and 2 As shown, the identification device 500 includes an identification detector 510 and a first moving device 520; the identification detector 510 is disposed on the first moving device 520, and the first moving device 520 can drive the identification detector 510 to move left and right at the top of the culture rack 100 to identify the incubator 200.

[0037] Specifically, each incubator 200 has a unique label. The identification detector 510 can identify and register each incubator 200. According to the control device 400, the culture parameters of the incubator 200 that requires customized culture can be adjusted to achieve the purpose of customized culture. The identification detector 510 performs motion detection, which can shorten the distance to the target, make identification faster, and increase the success rate.

[0038] Furthermore, the first moving device 520 is preferably an electric lead screw linear module.

[0039] In another embodiment of this utility model, according to Figure 2-4 As shown, each culture chamber 110 is provided with multiple connection ports 120 for connecting to the control device 400. One side of the incubator 200 is provided with an adapter 210 corresponding to the connection port 120. The connection port 120 and the adapter 210 can be matched and connected accordingly. It also includes multiple culture environment raw material tanks 130, which are connected to the connection ports 120 through pipes.

[0040] Specifically, the adapter 210 connects to the corresponding connector 120, and the control device 400 controls the temperature, humidity, and air content within the incubator 200, thereby regulating the culture environment within the incubator 200. Specifically, the connector 120 includes a power interface, an exhaust port, a carbon dioxide inlet, and a hydrogen peroxide inlet. Since environmental control is a conventional technique in this field, it will not be elaborated upon in this embodiment.

[0041] In another embodiment of this utility model, according to Figure 1 and 2 As shown, the transfer trolley 300 includes a main body 310; the main body 310 is equipped with a liftable support plate 320, which is used to support the incubator 200. Guide rails 330 are provided on both the support plate 320 and the bottom of the culture chamber 110, and corresponding pulley assemblies 260 are provided at the bottom of the incubator 200. The incubator 200 can be transferred from the culture chamber 110 to the required process by sliding. Specifically, the culture rack 100 is divided into two layers, and the support plate 320 can be raised and lowered to accommodate incubators 200 of different heights. Transporting via sliding is more labor-saving and efficient. Furthermore, regarding how the incubator 200 moves from the culture chamber 110 to the transfer trolley 300, the support plate 320 of the transfer trolley 300 is raised or lowered, and the guide rail 330 on the support plate 320 is aligned with the guide rail 330 of the culture chamber 110. The incubator 200 is driven to move onto the transfer trolley 300 via the pulley assembly 260. It can be understood that the support plate 320 and the culture chamber 110 can also be equipped with drive components to drive the transfer trolley 300, which can both achieve the goal of moving the incubator 200 from the culture chamber 110 onto the transfer trolley 300.

[0042] In another embodiment of this utility model, according to Figure 1 and 2 As shown, the control device 400 also includes a display screen 410, which is equipped with operation buttons 420. The operation buttons 420 can adjust various parameters. Specifically, the display screen 410 and operation buttons 420 can control the entire culture system more efficiently and simply.

[0043] In another embodiment of this utility model, such as Figure 3 and 4 As shown, the incubator 200 contains a petri dish 220, which includes multiple stacked culture chambers 221, each independent of the others. The petri dish 220 has channels 222, and each culture chamber 221 has a through-hole 223 communicating with the channel 222. The opening of the channel 222 is provided with a lid 224 for closing. Specifically, the petri dish 220 is a single, integral structure and cannot be disassembled. It is also made of transparent acrylic material.

[0044] In another embodiment of this utility model, such as Figure 3 and 4 As shown, the incubator 200 has an opening 230 connecting to the outside. Inside the incubator 200 is a second moving device (not shown), with a moving plate 240 on the second moving device. The petri dish 220 is placed on the moving plate 240. The moving plate 240 can extend or retract into the incubator 200 through the opening 230 via the second moving device. The opening 230 also has an openable and closable cover 250. Specifically, the petri dish 220 can extend or retract into the incubator 200 via the second moving device to facilitate fully automated operation during subsequent inoculation and collection processes. The second moving device can be an electric lead screw linear module or an electric push rod module, allowing the moving plate 240 to move according to the guide groove.

[0045] The above description, in conjunction with specific preferred embodiments, provides a further detailed explanation of this utility model. It should not be construed that the specific implementation of this utility model is limited to these descriptions. For those skilled in the art, the architectural form of this utility model can be flexibly varied without departing from its concept, and a series of products can be derived. Any simple deductions or substitutions should be considered as falling within the patent protection scope defined by the submitted claims.

Claims

1. An intelligent monitoring and identification device for cell culture, characterized in that, include: A culture rack is provided with multiple relatively independent culture chambers, and each culture chamber is provided with a culture box that can enter and exit the culture chamber. A transfer trolley, which can carry the incubator and transport it between the culture rack and other processes; A control device is located next to the culture rack and controls the culture environment of the incubator; An identification device is provided on the culture rack, which can identify and record information about the incubator transported to the culture rack by the transfer trolley.

2. The intelligent monitoring and identification cell culture device according to claim 1, characterized in that, The identification device includes an identification detector and a first moving device; the identification detector is disposed on the first moving device, and the first moving device can drive the identification detector to move left and right on the top of the culture rack to identify the incubator.

3. The intelligent monitoring and identification cell culture device according to claim 1, characterized in that, Each culture chamber is provided with multiple connection ports for connecting to the control device. One side of the culture chamber is provided with an adapter corresponding to the connection port. The connection port and the adapter can be matched and connected accordingly.

4. The intelligent monitoring and identification cell culture device according to claim 1, characterized in that, The transfer trolley includes a main body; the main body is provided with a liftable support plate, which is used to support the incubator.

5. The intelligent monitoring and identification cell culture device according to claim 4, characterized in that, Guide rails are provided on the support plate and the bottom of the culture chamber, and a corresponding pulley assembly is provided on the bottom of the culture box. The culture box can be moved from the culture chamber to the required process by sliding.

6. The intelligent monitoring and identification cell culture device according to claim 1, characterized in that, The control device also includes a display screen with operation buttons that can adjust various parameters.

7. The intelligent monitoring and identification cell culture device according to claim 1, characterized in that, The incubator contains a culture dish, which includes multiple stacked culture chambers, each of which is independent of the others. The culture dish has a channel, and each culture chamber has a through hole communicating with the channel. The opening of the channel is provided with a lid for closing.

8. The intelligent monitoring and identification cell culture device according to claim 7, characterized in that, The incubator has an opening that connects to the outside. The incubator is equipped with a second moving device, which has a moving plate. The petri dish is placed on the moving plate. The moving plate can extend out of the opening or retract into the incubator through the second moving device.

9. The intelligent monitoring and identification cell culture device according to claim 8, characterized in that, The opening is also provided with an openable and closable cover.

10. The intelligent monitoring and identification cell culture device according to claim 3, characterized in that, It also includes multiple culture environment material tanks, which are connected to the connection port via pipes.

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