A new improved high-voltage electric field spray device for preparing homogeneous tissue engineering micro-units

Abstract

The utility model discloses a novel improved high voltage electric field spray preparation homogeneous tissue engineering micro unit's equipment relates to the field of tissue engineering microcarrier manufacturing in biomedical engineering, including rotary needle cylinder, push rod and rotary stirring device, and the first end of push rod is provided with the piston, and the piston enters rotary needle cylinder from the big opening end of rotary needle cylinder, and the side of piston and the inner wall dynamic sealing contact of rotary needle cylinder, and the piston between the opening end of rotary needle cylinder is provided with sealing bearing, and the outer ring of sealing bearing contacts the inner wall of rotary needle cylinder, and the inner ring of sealing bearing contacts push rod stem, and rotary stirring device sets up on rotary needle cylinder. The utility model provides a novel improved high voltage electric field spray preparation homogeneous tissue engineering micro unit's equipment, and the solution of uniform solute distribution is obtained through the mode of stirring, when the microsphere spray is prepared in high pressure electrostatic, and the droplet composition of injection into high voltage electric field is high in consistency, and the composition between the generated tissue engineering micro unit is basically without difference.

Description

Technical Field

[0001] This utility model relates to the field of tissue engineering microcarrier manufacturing in biomedical engineering, and in particular to a novel improved device for preparing homogeneous tissue engineering microunits by high-voltage electric field spraying. Background Technology

[0002] Tissue engineering is a newly emerging discipline that has gained popularity in recent years. It applies the principles and technologies of life sciences and engineering to study and develop bio-substitutes for repairing, maintaining, and promoting the function and morphology of various human tissues or organs after injury, based on a correct understanding of the structural and functional relationships of tissues in both normal and pathological states in mammals. Examples include cartilage and bone tissue construction, tissue-engineered blood vessels, and neural tissue engineering. Tissue engineering microunits are the basic building blocks of materials used in tissue engineering to repair damaged tissues. Tissue engineering microunits are typically obtained by solidifying a prepared precursor solution. Currently, high-voltage electrostatic spraying is a commonly used method for preparing tissue engineering microunits, which uses high-voltage electrostatic force to atomize the precursor solution into microdroplets and then solidify them. However, existing equipment has the following key problems:

[0003] ① Inhomogeneous solution leads to differences in microsphere composition:

[0004] Chinese invention patent CN101653714A discloses a method and apparatus for preparing silk protein nanospheres using electrostatic spraying technology. In this method, the syringe is in a static liquid storage mode, and bioactive substances (such as growth factors and extracellular matrix) in the precursor solution are prone to sedimentation or aggregation due to density differences, leading to inconsistent substance content within the microspheres sprayed sequentially. An article published in "RscAdvances" in July 2016, titled "Electrospray biodegradable microcapsules loaded with curcumin for drug delivery systems with high bioactivity," mentions that when added substances affect parameters such as solution conductivity and surface tension, it alters the formation and spray trajectory of charged droplets, thus affecting the substance distribution within the microspheres. In experiments, the curcumin content loaded in the microspheres was measured to assess the differences, showing that the curcumin content in different batches of microspheres could vary by approximately 15%. The article "Research on Electrostatic Spraying Process for the Preparation of Nanosphere Composite Masks" published in Guangzhou Chemical Industry, No. 05, 2024, analyzed the composition of microspheres prepared under different conditions and found that the content of target substances in microspheres can vary by 10%-20% after the addition of extracellular matrix and other substances.

[0005] ②Insufficient process stability:

[0006] Most existing high-voltage electrostatic spraying equipment suffers from the problem of nozzle clogging caused by solid particles. An article titled "Advances in the Application of High-Voltage Electrostatic Spraying Technology for Drug Microcapsule Preparation," published in the 4th issue of the *Journal of Hebei United University* in 2013, mentions that solid particles in the precursor solution easily clog the nozzle during spraying, thus affecting the quality of the microspheres. The literature points out that nozzle clogging not only leads to unstable spraying, affecting the morphology and particle size distribution of the microspheres, but also reduces production efficiency and increases equipment maintenance costs.

[0007] Furthermore, for high-voltage electric field spraying, some existing literature uses mechanical stirring devices to recirculate and agitate the unsprayed solution, but it does not mention continuous agitation and mixing of the precursor solution before and during spraying. When using traditional mechanical devices to oscillate the solution, the impact of the oscillation amplitude on the stability of the electric field must be considered. Utility Model Content

[0008] The purpose of this invention is to provide a novel and improved device for preparing homogeneous tissue engineering microunits by high-voltage electric field spraying, in order to solve the problems existing in the prior art. By stirring, a solution with uniform solute distribution is obtained. When preparing tissue engineering microunits by high-voltage electrostatic spraying, the droplets sprayed into the high-voltage electric field have high consistency in composition, and the generated tissue engineering microunits have basically no difference in composition.

[0009] To achieve the above objectives, this utility model provides the following solution:

[0010] This invention provides a novel improved high-voltage electric field spray device for preparing homogeneous tissue engineering microunits, comprising a rotating syringe, a push rod, and a rotating stirring device. A piston is provided at the first end of the push rod, extending into the rotating syringe from its large opening. The side of the piston is in dynamic sealing contact with the inner wall of the rotating syringe. A sealed bearing is provided between the opening of the rotating syringe and the piston. The outer ring of the sealed bearing contacts the inner wall of the rotating syringe, and the inner ring of the sealed bearing contacts the push rod body. The rotating stirring device is mounted on the rotating syringe.

[0011] In one embodiment, the rotary stirring device includes a belt, a belt drive device, and a first rotary syringe mounting bracket. The inner ring of the belt contacts the outer wall of the rotary syringe. A first fixed bearing is provided on the first rotary syringe mounting bracket, and the rotary syringe is inserted into the inner ring of the first fixed bearing.

[0012] In one embodiment, the belt drive device includes a pulley and a first drive motor, wherein the inner ring of the belt contacts the outer ring of the pulley, and the output end of the first drive motor is connected to the driven end of the pulley.

[0013] In one embodiment, the rotary stirring device includes a gear ring, a gear ring drive device, and a second rotary syringe mounting bracket. The gear ring is an external gear ring, which is fixed to the outer wall of the rotary syringe. A second fixed bearing is provided on the second rotary syringe mounting bracket, and the rotary syringe is inserted into the inner ring of the second fixed bearing.

[0014] In one embodiment, the gear ring drive device includes a drive gear and a second drive motor. The drive gear is an external gear that meshes with the gear ring. The output end of the second drive motor is connected to the driven end of the drive gear.

[0015] In one embodiment, the rotary stirring device includes a magnetic stir bar, an electromagnetic coil assembly, and a controller. A portion of the cylindrical wall of the rotating syringe protrudes outward to form an annular space that completely accommodates the magnetic stir bar. The annular space communicates with the interior of the rotating syringe. The electromagnetic coil assembly is disposed outside the rotating syringe and surrounds the annular space. The electromagnetic coil assembly is a distributed three-phase winding with three independent coils evenly distributed along the circumference of the annular space. Each coil covers the range of the central angle of the annular space. The coils are wound in a clockwise direction, with the first end of the coil being a positive terminal and the last end being a negative terminal.

[0016] In one embodiment, the magnetic stirrer includes a ferrite core and a skin enclosing the ferrite core, the skin having shallow spiral patterns.

[0017] In one embodiment, the magnetic stir bar has a spherical structure.

[0018] In one embodiment, the coil has 100 turns.

[0019] In one embodiment, the system further includes a nozzle and a high-voltage electric field generator, wherein the inlet end of the nozzle is connected to the small opening end of the rotating syringe, and the high-voltage electric field generator is disposed at the outlet end of the nozzle.

[0020] The present invention achieves the following technical advantages over the prior art:

[0021] This invention provides a novel, improved high-voltage electric field spray device for preparing homogeneous tissue engineering microunits, which obtains a solution with uniform solute distribution through stirring. A rotating syringe serves as the stirring container, utilizing the friction between the solution and the inner wall of the syringe. As the syringe rotates, the solution inside is also driven to rotate, achieving stirring. The push rod advances simultaneously with the stirring, ensuring uniform solution distribution. A dynamic sealing contact between the piston and the inner wall of the syringe, along with a sealed bearing, prevents the push rod from rotating with the syringe, ensuring stable pushing and smooth rotation of the syringe. The piston and sealed bearing form a double-seal structure, preventing solution leakage from the large opening of the syringe. The inlet end of the nozzle is connected to the small opening end of the rotating syringe. The high-voltage electric field generator is set near the outlet end of the nozzle. The outlet end of the nozzle faces the high-voltage electric field. When preparing microspheres by high-voltage electrostatic spraying, the droplets can directly enter the high-voltage electric field. The droplets sprayed into the high-voltage electric field have high compositional consistency, and there is basically no difference in composition between the generated tissue engineering micro-units. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of a device structure for driving a rotating syringe cylinder with a belt, as described in an embodiment of this utility model.

[0024] Figure 2 This is a schematic diagram of the combined structure of the rotating syringe, belt, pulley and first drive motor in an embodiment of the present invention;

[0025] Figure 3 This is a schematic diagram of a device structure in which a gear drives a rotating syringe to rotate, according to an embodiment of the present invention.

[0026] Figure 4 This is a schematic diagram of a device for stirring a solution using a magnetic stir bar, as described in an embodiment of the present invention.

[0027] Figure 5 This is a schematic diagram of the structure of an electromagnetic coil assembly according to an embodiment of the present invention;

[0028] Figure 6 This is a schematic diagram of a three-phase circuit in an embodiment of the present invention.

[0029] The components include: 1. Rotary syringe; 2. Push rod; 3. Piston; 4. Sealed bearing; 5. Belt; 6. First rotary syringe mounting bracket; 7. Pulley; 8. First drive motor; 9. Gear ring; 10. Second rotary syringe mounting bracket; 11. Drive gear; 12. Second drive motor; 13. Magnetic stir bar; 14. Coil; 15. Nozzle; and 16. High-voltage electric field generator. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Those skilled in the art can easily understand other advantages and effects of the present utility model from the content disclosed in this specification. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0031] It should be understood that the structures, proportions, sizes, etc., depicted in the accompanying drawings are merely for illustrative purposes to aid those skilled in the art and to facilitate understanding. They are not intended to limit the implementation of this utility model and therefore have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and purpose of this utility model, should still fall within the scope of the technical content disclosed herein. In the description of this utility model, it should be understood that the terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are merely for the convenience of describing this utility model and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," and "third," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Therefore, features specified with "first," "second," etc., may explicitly or implicitly include one or more of those features. In the description of this utility model, unless otherwise stated, "multiple" means two or more.

[0032] It should also be noted that in the embodiments of this application, the same reference numerals are used to denote the same component or the same part.

[0033] The purpose of this invention is to provide a novel and improved device for preparing homogeneous tissue engineering micro-units by high-voltage electric field spraying, in order to solve the problems existing in the prior art. By stirring, a solution with uniform solute distribution is obtained. When preparing microspheres by high-voltage electrostatic spraying, the droplets sprayed into the high-voltage electric field have high consistency in composition, and the generated tissue engineering micro-units have basically no difference in composition.

[0034] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0035] Example 1

[0036] like Figures 1-6 As shown, this utility model provides a novel improved high-voltage electric field spray device for preparing homogeneous tissue engineering microunits, including a rotating syringe 1, a push rod 2, and a rotating stirring device. A piston 3 is provided at the first end of the push rod 2. The piston 3 extends into the rotating syringe 1 from the large opening end. The side of the piston 3 is in dynamic sealing contact with the inner wall of the rotating syringe 1. A sealing bearing 4 is provided between the piston 3 at the opening end of the rotating syringe 1. The outer ring of the sealing bearing 4 contacts the inner wall of the rotating syringe 1, and the inner ring of the sealing bearing 4 contacts the push rod 2. The rotating stirring device is provided on the rotating syringe 1.

[0037] Working principle:

[0038] This invention provides a novel, improved high-voltage electric field spray device for preparing homogeneous tissue engineering micro-units. It utilizes the friction between a rotating syringe 1 and the solution to agitate the solution within the syringe as it rotates. A push rod 2 serves as the solution discharge device, pushing forward while the syringe 1 rotates, ensuring uniform discharge of the solution through agitation. A piston 3 at the first end of the push rod 2 provides a seal but does not rotate with the syringe 1. The outer ring of a sealing bearing 4 rotates with the syringe 1, while the inner ring of the bearing fixes the push rod 2, ensuring stable pushing of the push rod 2 and smooth rotation of the syringe 1. The piston 3 and the sealing bearing 4 form a double-seal structure, preventing solution leakage from the large opening of the syringe 1.

[0039] In one embodiment, the sealed bearing 4 can be a contact sealed bearing, a non-contact sealed bearing, or a labyrinth sealed bearing. The contact sealed bearing includes a rubber seal ring disposed between the outer and inner rings of the bearing, with the rubber seal ring directly contacting the outer and inner rings. The non-contact sealed bearing includes a metal cover plate covering the space between the outer and inner rings of the bearing.

[0040] In one embodiment, the rotary stirring device includes a belt 5, a belt drive device, and a first rotary syringe mounting bracket 6. The inner ring of the belt 5 contacts the outer wall of the rotary syringe 1. A first fixed bearing is provided on the first rotary syringe mounting bracket 6, and the rotary syringe 1 is inserted into the inner ring of the first fixed bearing. The friction between the inner ring of the belt 5 and the outer wall of the rotary syringe 1 drives the rotary syringe 1 to rotate. This is suitable for stirring solutions with high viscosity and high friction with the inner wall of the rotary syringe 1.

[0041] In one embodiment, the belt drive device includes a pulley 7 and a first drive motor 8, the inner ring of the belt 5 is in contact with the outer ring of the pulley 7, and the output end of the first drive motor 8 is connected to the driven end of the pulley 7.

[0042] In one embodiment, the belt drive device is further provided with a belt tensioner.

[0043] In one embodiment, the rotary stirring device includes a gear ring 9, a gear ring drive device, and a second rotary syringe mounting bracket 10. The gear ring 9 is an external gear ring, fixed to the outer wall of the rotary syringe 1. A second fixed bearing is provided on the second rotary syringe mounting bracket 10, and the rotary syringe 1 is inserted into the inner ring of the second fixed bearing. The gear meshing transmission has good stability, large transmission power, and a wide speed adjustment range. When the solution being stirred has low viscosity and low friction with the inner wall of the rotary syringe 1, the stirring effect can be enhanced by increasing the speed.

[0044] In one embodiment, the gear ring drive device includes a drive gear 11 and a second drive motor 12. The drive gear 11 is an external gear and meshes with the gear ring 9. The output end of the second drive motor 12 is connected to the driven end of the drive gear 11.

[0045] In one embodiment, the rotary stirring device includes a magnetic stir bar 13, an electromagnetic coil assembly, and a controller. A portion of the wall of the rotating syringe 1 protrudes outward to form an annular space that completely accommodates the magnetic stir bar 13. This annular space communicates with the interior of the rotating syringe 1. The electromagnetic coil assembly is located outside the rotating syringe 1 and surrounds the annular space. The electromagnetic coil assembly is a distributed three-phase winding, with three independent coils 14 evenly distributed along the circumference of the annular space. Each coil 14 covers a central angle of 120 degrees within the annular space. The coils 14 are wound clockwise, with the first end of each coil being a positive terminal and the last end a negative terminal. Under the control of the electromagnetic coil assembly, the magnetic stir bar 13 moves repeatedly in one direction along the annular space, creating a circulating current in the solution within the rotating syringe 1. The solution within the rotating syringe 1 is drawn into this circulating current and discharged, achieving the effect of stirring the solution. The annular space completely accommodates the magnetic stir bar 13, preventing interference between the magnetic stir bar 13 and the moving push rod 2 during operation. The first independent coil 14 starts at 0° and is wound clockwise, with its ends marked A+ and A- respectively; the second independent coil 14 starts at 120° and is wound clockwise, with its ends marked B+ and B- respectively; the third independent coil 14 starts at 240° and is wound clockwise, with its ends marked C+ and C- respectively. The ends (A-, B-, C-) of the three coils 14 are connected to the negative terminal of the power supply, and the beginnings (A+, B+, C+) are connected to the three-phase drive circuit. When the electromagnetic coil group is working, a three-phase current input is used, and a three-phase sinusoidal alternating current with a phase difference of 120° is applied. The coils rotate along a circular ring at an angular velocity, forming a traveling wave magnetic field. A three-phase full-bridge inverter is used to convert the DC power to three-phase AC power. The microcontroller generates three PWM signals with a phase difference of 120°.

[0046] In one embodiment, the cross-sectional shape of the annular space is semi-elliptical. It is understood that the cross-sectional shape of the annular space can also be arc, semi-circular, polygonal, or other shapes that enable the magnetic stir bar 13 to work normally.

[0047] In one embodiment, the magnetic stir bar 13 includes a ferrite core and a skin enclosing the ferrite core, with shallow spiral patterns formed on the skin. The shallow spiral patterns are micron-scale spiral groove structures that serve a guiding function. Forming shallow spiral patterns on the skin of the magnetic stir bar 13 can improve its motion stability. The shallow spiral patterns can be single spiral patterns, double spiral patterns, or a mixture of single and double spiral patterns.

[0048] In one embodiment, the skin material is one of polytetrafluoroethylene (PTFE), glass, silicone rubber, ceramic, or metal.

[0049] In one embodiment, the magnetic stir bar 13 has a spherical structure.

[0050] In one configuration, coil 14 has 100 turns. The number of turns of coil 14 is matched to the required magnetic field strength, and it is understood that the number of turns of coil 14 can be adjusted as needed.

[0051] In one embodiment, the present invention further includes a nozzle 15 and a high-voltage electric field generator 16. The inlet end of the nozzle 15 is connected to the small opening end of the rotating syringe 1, and the high-voltage electric field generator 16 is positioned near the outlet end of the nozzle 15, with the outlet end of the nozzle 15 facing the high-voltage electric field. During operation, the solution discharged from the rotating syringe 1 is sprayed out through the nozzle 15, and under the influence of the high-voltage electric field, the droplets atomize to form solidified particle spray. Because the solution discharged from the rotating syringe 1 is uniform, the composition of the formed solidified particles is also consistent.

[0052] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0053] If this utility model discloses or relates to mutually fixedly connected parts or structural components, then, unless otherwise stated, a fixed connection can be understood as: a detachable fixed connection (e.g., using bolts or screws), or a non-detachable fixed connection (e.g., riveting, welding). Of course, mutually fixed connections can also be replaced by an integral structure (e.g., manufactured using a casting process) (except where it is obviously impossible to use an integral forming process).

[0054] In addition, unless otherwise stated, the terms used to indicate positional relationships or shapes in any of the technical solutions disclosed in this utility model above include states or shapes that are similar to, close to, or approximate with them.

[0055] Any component provided by this utility model can be assembled from multiple individual components, or it can be a single component manufactured by a one-piece molding process.

[0056] Any adaptive changes made according to actual needs are within the protection scope of this utility model.

[0057] It should be noted that, for those skilled in the art, it is obvious that this utility model is not limited to the details of the above exemplary embodiments, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this utility model. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of this utility model is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this utility model. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0058] This utility model uses specific examples to illustrate its principles and implementation methods. The above description of the embodiments is only for the purpose of helping to understand the method and core idea of ​​this utility model. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the idea of ​​this utility model. In summary, the content of this specification should not be construed as a limitation of this utility model.

Claims

1. A novel, improved high-voltage electric field spray device for preparing homogeneous tissue engineering microunits, characterized in that: The device includes a rotating syringe (1), a push rod (2), and a rotating stirring device. A piston (3) is provided at the first end of the push rod (2). The piston (3) extends into the rotating syringe (1) from the large opening end of the rotating syringe (1). The side of the piston (3) is in dynamic sealing contact with the inner wall of the rotating syringe (1). A sealing bearing (4) is provided between the opening end of the rotating syringe (1) and the piston (3). The outer ring of the sealing bearing (4) contacts the inner wall of the rotating syringe (1), and the inner ring of the sealing bearing (4) contacts the rod body of the push rod (2). The rotating stirring device is provided on the rotating syringe (1).

2. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 1, characterized in that: The rotating stirring device includes a belt (5), a belt drive device and a first rotating syringe mounting bracket (6). The inner ring of the belt (5) contacts the outer wall of the rotating syringe (1). A first fixed bearing is provided on the first rotating syringe mounting bracket (6), and the rotating syringe (1) is inserted into the inner ring of the first fixed bearing.

3. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 2, characterized in that: The belt drive device includes a pulley (7) and a first drive motor (8). The inner ring of the belt (5) is in contact with the outer ring of the pulley (7). The output end of the first drive motor (8) is connected to the driven end of the pulley (7).

4. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 1, characterized in that: The rotary stirring device includes a gear ring (9), a gear ring drive device, and a second rotary syringe mounting bracket (10). The gear ring (9) is an outer gear ring, and the gear ring (9) is fixed on the outer wall of the rotary syringe (1). A second fixed bearing is provided on the second rotary syringe mounting bracket (10), and the rotary syringe (1) is inserted into the inner ring of the second fixed bearing.

5. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 4, characterized in that: The gear ring drive device includes a drive gear (11) and a second drive motor (12). The drive gear (11) is an external gear and meshes with the gear ring (9). The output end of the second drive motor (12) is connected to the driven end of the drive gear (11).

6. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 1, characterized in that: The rotary stirring device includes a magnetic stir bar (13), an electromagnetic coil assembly, and a controller. Part of the cylindrical wall of the rotary syringe (1) protrudes outward to form an annular space that completely accommodates the magnetic stir bar (13). The annular space is connected to the interior of the rotary syringe (1). The electromagnetic coil assembly is located outside the rotary syringe (1) and surrounds the annular space. The electromagnetic coil group is a distributed three-phase winding, with three independent coils (14) evenly distributed along the circumference of the annular space. Each coil (14) covers a range of 120 degrees from the central angle of the annular space. The coils (14) are wound in a clockwise direction. The first end of the coil (14) is a positive connection end, and the last end of the coil (14) is a negative connection end.

7. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 6, characterized in that: The magnetic stir bar (13) includes a ferrite core and a skin that encloses the ferrite core, and the skin is provided with shallow spiral patterns.

8. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 6, characterized in that: The magnetic stir bar (13) has a spherical structure.

9. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 6, characterized in that: The coil (14) has 100 turns.

10. The device for preparing homogeneous tissue engineering microunits by novel improved high-voltage electric field spraying according to claim 1, characterized in that: It also includes a nozzle (15) and a high-voltage electric field generator (16). The inlet end of the nozzle (15) is connected to the small opening end of the rotating syringe (1), and the high-voltage electric field generator (16) is located at the outlet end of the nozzle (15).

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