Multichannel liquid-based cell collection and separation filter kit

Abstract

The utility model relates to the field of biomedical technology, and disclose multi -passage liquid -based cell collection and separation filter kit;Including box body and connecting pipe, the outside of connecting pipe is fixed with support frame, the inside of support frame is provided with dismounting assembly, the one side of dismounting assembly is provided with clamping ring, the one end of connecting pipe is linked with collecting pipe;The utility model discloses through pressing multiple groups of pressing type hose simultaneously, drives the collection head to be through sample pipe and make sample be drained to the flow guide pipe through the flow guide type hose quickly, then imports the filter pipe from the flow guide pipe, realizes multi -passage parallel collection, greatly promoted sample collection efficiency, after sample enters filter pipe, passes through rough filter screen, middle filter screen and fine filter screen in proper order, and rough filter screen effectively intercepts the large particle impurity in sample, and middle filter screen further filters cell mass, and fine filter screen then accurate capture target cell, reach the fractional separation of cell, ensure the accuracy and reliability of subsequent detection.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to a multichannel liquid-based cell collection and separation filtration kit. Background Technology

[0002] Liquid-based cytology refers to cell samples obtained through liquid-based thin-layer cytology detection technology. This technology places the collected cell samples in a special preservation solution and removes impurities through centrifugation, filtration, and other steps, allowing the cells to be evenly dispersed and made into a thin-layer smear. Compared with traditional smears, liquid-based cytology smears have a clearer background and more complete cell morphology, which can significantly improve the detection rate of abnormal cells and reduce the risk of missed diagnoses. Liquid-based cytology technology is widely used in cervical cancer screening, sputum, urine and other body fluid cytology examinations, providing more reliable cytological evidence for clinical diagnosis.

[0003] Liquid-based cytology kits require multi-channel acquisition and separation / filtration because they improve detection efficiency and accuracy. The multi-channel design allows for simultaneous processing of multiple samples, saving time; the separation / filtration function effectively removes impurities and concentrates target cells, resulting in more uniform cell distribution and clearer morphology, which is beneficial for subsequent microscopic observation and pathological diagnosis. Existing liquid-based cytology kits lack a multi-channel parallel acquisition module, meaning they can only process a single sample at a time. This is inefficient in large-scale screening or scenarios requiring efficient processing of multiple samples, increasing time costs. Furthermore, the lack of a graded separation component prevents precise separation based on cell size, morphology, and other characteristics, making it difficult to effectively remove impurities such as blood and mucus. This results in low target cell purity, affecting the accuracy of subsequent microscopic observation and pathological diagnosis, thus limiting the kit's application in clinical diagnosis.

[0004] Therefore, it is necessary to provide a new multi-channel liquid-based cell collection and separation filtration kit to solve the above-mentioned technical problems. Utility Model Content

[0005] The purpose of this invention is to provide a multi-channel liquid-based cell collection and separation filtration kit to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a multi-channel liquid-based cell collection and separation filtration kit, comprising a box and a connecting tube, wherein a support frame is fixed to the outside of the connecting tube, a disassembly assembly is provided inside the support frame, a clamping ring is provided on one side of the disassembly assembly, and a collection tube is connected to one end of the connecting tube;

[0007] A filter tube is connected to the inner wall of a connecting tube. The filter tube is equipped with a separation component for separating cells. A fixing ring is fixed to the outer side of the filter tube. An installation component is installed inside the fixing ring.

[0008] A collection component is disposed at one end of a connecting tube. A sample is disposed at one end of the collection component, and the outer side of the sample is inserted into the inner wall of the box.

[0009] Preferably, a limiting rod is fixed to the outer side of the clamping ring, a limiting plate is fixed to one end of the limiting rod, and the outer side of the limiting rod is slidably connected to the inner wall of the support frame.

[0010] Preferably, the disassembly assembly includes a threaded rod threaded to the inner wall of the support frame, one end of the threaded rod being fixed to a turntable, and the other end of the threaded rod being rotatably connected to the outer side of the clamping ring.

[0011] Preferably, the separation assembly includes a coarse filter, a medium filter, and a fine filter, which are respectively snapped onto the inner wall of the filter tube.

[0012] Preferably, the mounting assembly includes a bolt threaded to the inner wall of the retaining ring, and one end of the bolt is fixed to a mounting plate.

[0013] Preferably, the acquisition component includes a guide tube connected to one end of the connecting tube, and one end of the guide tube is connected to a press-type flexible tube.

[0014] Preferably, the acquisition component further includes a flow guide hose connected to one end of the press-type hose, one end of the flow guide hose being connected to a acquisition head, and one end of the acquisition head being connected to one end of the sample.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] This invention enables multi-channel parallel sampling by simultaneously pressing multiple sets of press-type flexible tubes, driving the sampling head to quickly guide the sample through the sample tube and then through the flow-guiding flexible tube to the flow-guiding tube, and then through the flow-guiding tube to the filter tube. This greatly improves the sample collection efficiency. After entering the filter tube, the sample passes through a coarse filter, a medium filter, and a fine filter in sequence. The coarse filter effectively intercepts large particulate impurities in the sample, the medium filter further filters cell clumps, and the fine filter accurately captures target cells, achieving graded separation of cells and ensuring the accuracy and reliability of subsequent detection. Attached Figure Description

[0017] Figure 1 A schematic diagram of a preferred embodiment of the multichannel liquid-based cell collection and separation filtration kit provided by this utility model;

[0018] Figure 2 This is a schematic diagram of the disassembly components in this utility model;

[0019] Figure 3 This is a schematic diagram of the installation components in this utility model;

[0020] Figure 4This is a schematic diagram of the structure of the separation component in this utility model;

[0021] Figure 5 This is a schematic diagram of the acquisition component in this utility model.

[0022] In the diagram: 1. Box body; 2. Connecting pipe; 3. Support frame; 4. Disassembly assembly; 41. Threaded rod; 42. Turntable; 5. Clamping ring; 6. Collection pipe; 7. Filter pipe; 8. Separation assembly; 81. Coarse filter screen; 82. Medium filter screen; 83. Fine filter screen; 9. Fixing ring; 10. Mounting assembly; 101. Bolt; 102. Mounting plate; 11. Collection assembly; 111. Guide pipe; 112. Press-type hose; 113. Guide hose; 114. Collection head; 12. Sample tube; 13. Limiting rod; 14. Limiting plate. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-5 As shown, the multichannel liquid-based cell collection and separation filtration kit includes a box body 1 and a connecting tube 2. The connecting tube 2 is fixed to the inner wall of the box body 1, and a support frame 3 is fixed to the outer side of the connecting tube 2. A disassembly component 4 is provided inside the support frame 3, and a clamping ring 5 is provided on one side of the disassembly component 4. One end of the connecting tube 2 is connected to a collection tube 6. The box body 1 can fix the connecting tube 2, and the connecting tube 2 can support the support frame 3. The disassembly component 4 drives the clamping ring 5 to move so that the clamping ring 5 moves to fit against the outer side of the collection tube 6, so as to achieve the effect of connecting the collection tube 6 and the connecting tube 2, which facilitates the subsequent collection of separated cells and the disassembly of the collection tube 6, which facilitates the subsequent cleaning or replacement of the collection tube 6.

[0025] The filter tube 7 is connected to the inner wall of the connecting tube 2. The filter tube 7 is equipped with a separation component 8 for separating cells. A fixing ring 9 is fixed to the outside of the filter tube 7. An installation component 10 is installed inside the fixing ring 9. There are two sets of filter tubes 7, and a rotating shaft is fixed to one end of each set of filter tubes 7. The filter tube 7 is equipped with multiple sets of slots. There are two sets of fixing rings 9, and the two sets of fixing rings 9 are fixed to the outside of the two sets of filter tubes 7 respectively. Cells flow into the filter tube 7 through the connecting tube 2, so that the separation component 8 can separate the cells in stages to ensure the accuracy and reliability of subsequent detection. When it is necessary to remove the separated cells, the installation component 10 is separated from the two sets of fixing rings 9. One set of filter tubes 7 is pulled to open and close with the other set of filter tubes 7 through the rotating shaft. The separated cells can then be removed, which is convenient for subsequent microscopic observation and pathological diagnosis of the cells and avoids the problem of not being able to perform fine separation based on cell size, morphology and other characteristics.

[0026] The acquisition component 11 is located at one end of the connecting tube 2. A sample tube 12 is provided at one end of the acquisition component 11, and the outer side of the sample tube 12 is inserted into the inner wall of the box 1. Multiple sets of acquisition components 11 are provided. By setting multiple sets of acquisition components 11 at the same time, the sample can be drawn from the sample tube 12 into the filter tube 7, which facilitates the subsequent implementation of multi-channel parallel acquisition and avoids the problem of low efficiency in scenarios that require efficient processing of multiple samples.

[0027] A limiting rod 13 is fixed to the outer side of the clamping ring 5, and a limiting disk 14 is fixed to one end of the limiting rod 13. The outer side of the limiting rod 13 is slidably connected to the inner wall of the support frame 3. The clamping ring 5 drives the limiting rod 13 to move, so that the limiting rod 13 slides along the inner wall of the support frame 3, thereby limiting the limiting disk 14. This facilitates the subsequent movement of the clamping ring 5 by the threaded rod 41, and improves the stability when fixing the collection tube 6.

[0028] The disassembly assembly 4 includes a threaded rod 41 threaded to the inner wall of the support frame 3. One end of the threaded rod 41 is fixed to a turntable 42, and the other end of the threaded rod 41 is rotatably connected to the outer side of the clamping ring 5. By rotating the turntable 42, the threaded rod 41 is driven to rotate, and the threaded rod 41 rotates along the threaded inner wall of the support frame 3 to drive the clamping ring 5 to move, so that the clamping ring 5 fits against the outer side of the collection tube 6, which facilitates the subsequent installation or disassembly of the collection tube 6 and provides flexibility in the use of the device.

[0029] The separation component 8 includes a coarse filter 81, a medium filter 82, and a fine filter 83, which are respectively attached to the inner wall of the filter tube 7. After the sample enters the filter tube 7, it passes through the coarse filter 81, the medium filter 82, and the fine filter 83 in sequence. The coarse filter 81 effectively intercepts large particulate impurities in the sample, the medium filter 82 further filters cell clumps, and the fine filter 83 accurately captures target cells, achieving graded separation of cells and ensuring the accuracy and reliability of subsequent detection.

[0030] The mounting assembly 10 includes a bolt 101 threaded to the inner wall of the fixing ring 9. One end of the bolt 101 is fixed to a mounting plate 102. When the cells need to be removed after separation, the bolt 101 is rotated by rotating the mounting plate 102, causing the bolt 101 to rotate along the inner wall of the fixing ring 9, thus separating the bolt 101 from the fixing ring 9. This allows one set of filter tubes 7 to be pulled and opened / closed with another set of filter tubes 7 via a rotating shaft, enabling the separated cells to be removed. This facilitates subsequent microscopic observation and pathological diagnosis of the cells, avoiding the problem of not being able to perform precise separation based on cell size, morphology, and other characteristics.

[0031] The acquisition component 11 includes a guide tube 111 connected to one end of the connecting tube 2. One end of the guide tube 111 is connected to a press-type hose 112. The acquisition component 11 also includes a guide hose 113 connected to one end of the press-type hose 112. One end of the guide hose 113 is connected to a acquisition head 114, and one end of the acquisition head 114 is connected to one end of the sample tube 12. By pressing multiple sets of press-type hoses 112 simultaneously, the acquisition head 114 is driven to quickly guide the sample through the guide hose 113 to the guide tube 111 via the sample tube 12, and then guide the sample into the filter tube 7 through the guide tube 111, realizing multi-channel parallel acquisition and greatly improving the sample acquisition efficiency.

[0032] Working Principle: When using this device, the operator first rotates the turntable 42. This rotation drives the threaded rod 41 to rotate, which in turn rotates along the inner wall of the support frame 3, causing the clamping ring 5 to move. The clamping ring 5 then comes into contact with the outer side of the collection tube 6, connecting the collection tube 6 to the connecting tube 2. When cell collection is needed, multiple sets of press-type tubing 112 are pressed simultaneously, driving the collection head 114 to quickly guide the sample through the sample tube 12 and the flow-guiding tubing 113 to the guide tube 111. The sample is then introduced into the filter tube 7 via the guide tube 111, achieving multi-channel parallel collection and greatly improving sample collection efficiency. When the sample flows to the... When passing through filter tube 7, the cells sequentially pass through coarse filter 81, medium filter 82, and fine filter 83. Coarse filter 81 effectively intercepts large particulate impurities in the sample, medium filter 82 further filters cell clumps, and fine filter 83 precisely captures target cells. When the target cells need to be removed after separation, the mounting plate 102 is rotated to drive the bolt 101 to rotate. The bolt 101 rotates along the inner wall of the fixing ring 9, causing the bolt 101 to separate from the fixing ring 9. This pulls one set of filter tubes 7 to open and close with another set of filter tubes 7 via a rotating shaft, allowing the separated cells to be removed. This facilitates subsequent microscopic observation and pathological diagnosis of the cells, avoiding the problem of not being able to perform fine separation based on cell size, morphology, and other characteristics.

[0033] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multichannel liquid-based cell collection and separation filtration kit, comprising a housing (1), characterized in that, Also includes: A connecting tube (2) is fixed to the inner wall of the box (1). A support frame (3) is fixed to the outside of the connecting tube (2). A disassembly assembly (4) is provided inside the support frame (3). A clamping ring (5) is provided on one side of the disassembly assembly (4). A collection tube (6) is connected to one end of the connecting tube (2). A filter tube (7) is connected to the inner wall of the connecting tube (2). The filter tube (7) is provided with a separation component (8) for separating cells. A fixing ring (9) is fixed on the outside of the filter tube (7). An installation component (10) is provided inside the fixing ring (9). A collection component (11) is disposed at one end of a connecting tube (2). A sample tube (12) is disposed at one end of the collection component (11), and the outer side of the sample tube (12) is inserted into the inner wall of the box (1).

2. The multichannel liquid-based cell collection and separation filtration kit according to claim 1, characterized in that: A limiting rod (13) is fixed to the outside of the clamping ring (5), and a limiting disk (14) is fixed to one end of the limiting rod (13). The outside of the limiting rod (13) is slidably connected to the inner wall of the support frame (3).

3. The multichannel liquid-based cell collection and separation filtration kit according to claim 1, characterized in that: The disassembly assembly (4) includes a threaded rod (41) threaded to the inner wall of the support frame (3), one end of which is fixed to a turntable (42), and the other end of which is rotatably connected to the outer side of the clamping ring (5).

4. The multichannel liquid-based cell collection and separation filtration kit according to claim 1, characterized in that: The separation component (8) includes a coarse filter (81), a medium filter (82), and a fine filter (83) respectively attached to the inner wall of the filter tube (7).

5. The multichannel liquid-based cell collection and separation filtration kit according to claim 1, characterized in that: The mounting assembly (10) includes a bolt (101) threaded to the inner wall of the retaining ring (9), one end of which is fixed to a mounting plate (102).

6. The multichannel liquid-based cell collection and separation filtration kit according to claim 1, characterized in that: The acquisition component (11) includes a guide tube (111) connected to one end of the connecting tube (2), and one end of the guide tube (111) is connected to a press-type flexible tube (112).

7. The multichannel liquid-based cell collection and separation filtration kit according to claim 6, characterized in that: The acquisition component (11) also includes a flow guide hose (113) connected to one end of the press-type hose (112), one end of the flow guide hose (113) is connected to the acquisition head (114), and one end of the acquisition head (114) is connected to one end of the sample tube (12).

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