Heparin sodium extraction solution precision filtering equipment
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- HENGNAN HUARUIRUNYUE BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-05-26
- Publication Date
- 2026-06-02
Smart Images
Figure CN224308013U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of filtration components, specifically to a precision filtration device for heparin sodium extract. Background Technology
[0002] In the pharmaceutical and chemical industries, heparin sodium is widely used in clinical treatment and biomedical research, playing an anticoagulant role. Heparin sodium is mainly extracted from the small intestinal mucosa of pigs and sheep and the lungs of cattle. Studies have shown that the highest content of heparin sodium is found in the small intestinal mucosa of pigs.
[0003] However, existing heparin sodium extract filtration equipment lacks effective integration of pre-extraction processing. Processes such as small intestinal mucosal disruption and enzymatic hydrolysis are independent of the filtration stage, lacking systematic integration. This application achieves a fully integrated operation from raw material processing to filtration by integrating pre-extraction processing equipment and static separation structures. Utility Model Content
[0004] To address the aforementioned problems, this utility model proposes a precision filtration device for heparin sodium extract, comprising a filter box with an oil-floating filter plate installed inside; a meat grinding box for breaking down the small intestinal mucosa, a heating and stirring box located to the side of the meat grinding box, and a settling cylinder located to the side of the heating and stirring box. The settling cylinder is a semi-cylindrical shape with an open top, and a mounting groove is provided at one end of the top of the settling cylinder. An outwardly extending curved spout is welded to the mounting groove. The filter box is located below the settling cylinder. A supporting arc seat is provided at the bottom of the settling cylinder, and the settling cylinder is rotatably connected to the supporting arc seat. A rotating shaft is fixed at the center of the end face of the settling cylinder, and a geared motor is connected to the other end of the rotating shaft.
[0005] Furthermore, a grinding rod is rotatably connected inside the meat grinding box, and multiple roller blades are fixed on the outer side of the grinding rod; a stirring rod is rotatably connected inside the heating and mixing box, and multiple stirring plates are fixed on the outer side of the stirring rod; a stirring cover is installed on the top of the heating and mixing box, and multiple electric heating tubes are installed at the bottom of the stirring cover; the grinding rod and the stirring rod extend outside the meat grinding box and the heating and mixing box respectively, and both the grinding rod and the stirring rod are connected to an external drive motor.
[0006] Furthermore, the bottom of the meat grinding box is connected to a meat conveying pipe, the other end of which extends into the heating and mixing box; the bottom of the heating and mixing box is connected to a mixing conveying pipe, the other end of which extends above the settling cylinder.
[0007] Furthermore, both the minced meat conveying pipeline and the mixing conveying pipeline are equipped with on / off valves.
[0008] Furthermore, a temperature sensor is installed inside the heating mixing tank.
[0009] The beneficial effects of this utility model are as follows:
[0010] 1. The equipment integrates multiple processes such as small intestinal mucosa crushing, heating and enzymatic hydrolysis, static separation and filtration into one unit, reducing the number of times materials are transferred between different equipment and reducing component loss and contamination risk; the rotatable structure design of the static cylinder allows the material to be completely poured into the filter box through the curved spout, avoiding material residue and facilitating cleaning.
[0011] 2. The equipment achieves automated connection between various processes through motor drive and pipeline transportation, reducing manual intervention and minimizing product quality fluctuations caused by human operation errors. Attached Figure Description
[0012] Figure 1 This is a schematic diagram of the internal structure of the present invention;
[0013] Figure 2 for Figure 1 A top view of the structure of the stationary cylinder.
[0014] The following are the annotations in the attached diagram: 1. Filter box; 2. Oil filter plate; 3. Meat mincing box; 31. Mincing rod; 32. Roller blade; 4. Heating and mixing box; 41. Mixing rod; 42. Mixing plate; 43. Mixing top cover; 44. Electric heating tube; 5. Settling cylinder; 6. Curved spout; 7. Support arc seat; 8. Rotating shaft; 9. Gear motor; 10. Meat mincing conveying pipe; 11. Mixing conveying pipe; 12. On / off valve; 13. Temperature sensor. Detailed Implementation
[0015] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.
[0016] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.
[0017] The present invention will be further described below with reference to the accompanying drawings:
[0018] Precision filtration equipment for heparin sodium extract, such as Figure 1 and Figure 2 As shown, the system includes a filter box 1, inside which an oil-floating filter plate 2 is installed; a meat grinding box 3 for breaking up the small intestine mucosa is provided, a heating and stirring box 4 is provided on the side of the meat grinding box 3, and a settling cylinder 5 is provided on the side of the heating and stirring box 4. The settling cylinder 5 is a semi-cylindrical shape with an open top, and an installation groove is provided at one end of the top of the settling cylinder 5. An outwardly extending curved spout 6 is welded to the installation groove. The filter box 1 is located below the settling cylinder 5; a supporting arc seat 7 is provided at the bottom end of the settling cylinder 5, and the settling cylinder 5 is rotatably connected to the supporting arc seat 7. A rotating shaft 8 is fixed at the center of the end face of the settling cylinder 5, and a geared motor 9 is connected to the other end of the rotating shaft 8.
[0019] Among them, the filter box 1 is equipped with the oil-floating filter plate 2 to filter the extract; the meat mincing box 3, the heating and stirring box 4 and the settling cylinder 5 are connected in sequence to form a raw material processing chain; the semi-cylindrical settling cylinder 5, together with the curved spout 6, the supporting arc seat 7 and the reduction motor 9, realizes material separation and transfer.
[0020] like Figure 1 As shown, in this embodiment, a grinding rod 31 is rotatably connected inside the meat grinding box 3, and multiple roller blades 32 are fixed on the outer side of the grinding rod 31; a stirring rod 41 is rotatably connected inside the heating and stirring box 4, and multiple stirring plates 42 are fixed on the outer side of the stirring rod 41; a temperature sensor 13 is installed inside the heating and stirring box 4; a stirring top cover 43 is installed on the top of the heating and stirring box 4; and multiple electric heating tubes 44 are installed at the bottom of the stirring top cover 43; the grinding rod 31 and the stirring rod extend outside the meat grinding box 3 and the heating and stirring box 4, respectively; and both the grinding rod 31 and the stirring rod are connected to an external drive motor. The bottom of the meat grinding box 3 is connected to a meat conveying pipe 10, and the other end of the meat conveying pipe 10 extends into the heating and mixing box 4; the bottom of the heating and mixing box 4 is connected to a mixing conveying pipe 11, and the other end of the mixing conveying pipe 11 extends above the settling cylinder 5; both the meat conveying pipe 10 and the mixing conveying pipe 11 are equipped with on / off valves 12.
[0021] Among them, the crushing rotating rod 31 and the roller 32 crush the small intestinal mucosa; the stirring rotating rod 41, stirring plate 42, temperature sensor 13 and electric heating tube 44 work together to realize the enzymatic hydrolysis of materials; the conveying pipeline and the opening and closing valve 12 control the flow of materials, so that each link is connected in an orderly manner.
[0022] The working principle of this utility model is as follows:
[0023] The working process of this heparin sodium extract precision filtration equipment includes multiple steps such as small intestinal mucosa disruption, heating and enzymatic hydrolysis, static separation and filtration, to achieve the filtration of heparin sodium extract.
[0024] In the small intestinal mucosa crushing stage, an external drive motor drives the crushing rod 31 to rotate, and the roller blade 32 fixed on the outer side of the crushing rod 31 rotates accordingly. The roller blade 32 uses shearing force to crush the small intestinal mucosa poured into the meat crushing box 3 into a morsel-like state, causing the mucosal cells to break down.
[0025] In the heating and enzymatic hydrolysis stage, an externally driven motor also rotates the stirring rod 41. The stirring rod 41 drives the stirring plate 42 to rotate within the heating and mixing chamber 4, mixing the added small intestinal mucosal paste, water, trypsin, and weakly alkaline liquid to ensure uniform distribution of the various components and accelerate the enzymatic hydrolysis reaction. After the electric heating tube 44 is connected to the power supply, it converts electrical energy into heat energy to heat the materials in the heating and mixing chamber 4. The temperature sensor 13 monitors the temperature inside the chamber in real time and feeds the temperature signal back to the control system. When the temperature deviates from the set range, the control system automatically adjusts the power of the electric heating tube 44 to maintain a stable temperature. At the same time, by adding a weakly alkaline liquid, the pH value of the reaction environment is controlled between 8 and 9 (in this embodiment, specifically, the pH value is maintained between 8 and 9, and the heating temperature is between 35 and 50°C), providing suitable reaction conditions for trypsin, enabling the enzymatic hydrolysis reaction to proceed efficiently and allowing effective components such as heparin sodium to be fully released from the mucosal cells.
[0026] In the settling and separation stage, the enzymatically hydrolyzed material enters the settling cylinder 5 through the mixing and conveying pipe 11. The settling cylinder 5 is semi-cylindrical with an open top. After the material enters, because the density of the floating oil is less than that of the extract, the floating oil gradually floats upward and accumulates above the liquid surface during the settling process. When the floating oil has fully accumulated, the reduction motor 9 starts, and the output shaft of the reduction motor 9 drives the rotating shaft 8 to rotate. The rotating shaft 8 is fixedly connected to the settling cylinder 5, thereby driving the settling cylinder 5 to rotate around its own axis on the supporting arc seat 7. As the settling cylinder 5 rotates, the material moves towards the curved spout 6 under the combined action of centrifugal force and gravity, and finally flows smoothly into the filter box 1 below through the curved spout 6.
[0027] The material poured into the filter box 1 first passes through the floating oil filter plate 2, which intercepts solid impurities in the material while allowing the extract to pass through, thus completing the filtration process. Subsequent washing and dehydration processes will yield heparin sodium.
[0028] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.
Claims
1. A precision filtration device for heparin sodium extract, comprising a filter box (1), wherein an oil-floating filter plate (2) is installed inside the filter box (1); characterized in that: A meat grinding box (3) for breaking up the small intestine mucosa is provided. A heating and stirring box (4) is provided on the side of the meat grinding box (3). A settling cylinder (5) is provided on the side of the heating and stirring box (4). The settling cylinder (5) is a semi-cylindrical shape with an open top. An installation groove is provided at one end of the top of the settling cylinder (5). An outwardly extending curved spout (6) is welded on the installation groove. The filter box (1) is located below the settling cylinder (5). A support arc seat (7) is provided at the bottom of the settling cylinder (5). The settling cylinder (5) is rotatably connected to the support arc seat (7). A rotating shaft (8) is fixed at the center of the end face of the settling cylinder (5). A geared motor (9) is connected to the other end of the rotating shaft (8).
2. The precision filtration device for heparin sodium extract according to claim 1, characterized in that: A grinding rod (31) is rotatably connected inside the meat grinding box (3), and multiple rollers (32) are fixed on the outer side of the grinding rod (31); a stirring rod (41) is rotatably connected inside the heating and stirring box (4), and multiple stirring plates (42) are fixed on the outer side of the stirring rod (41); a stirring top cover (43) is installed on the top of the heating and stirring box (4), and multiple electric heating tubes (44) are installed at the bottom of the stirring top cover (43); the grinding rod (31) and the stirring rod extend to the outside of the meat grinding box (3) and the heating and stirring box (4) respectively, and both the grinding rod (31) and the stirring rod are connected to an external drive motor.
3. The precision filtration device for heparin sodium extract according to claim 1, characterized in that: The bottom of the meat grinding box (3) is connected to a meat conveying pipe (10), and the other end of the meat conveying pipe (10) extends into the heating and mixing box (4); the bottom of the heating and mixing box (4) is connected to a mixing conveying pipe (11), and the other end of the mixing conveying pipe (11) extends above the settling cylinder (5).
4. The precision filtration device for heparin sodium extract according to claim 3, characterized in that: Both the meat filling conveying pipe (10) and the mixing conveying pipe (11) are equipped with on / off valves (12).
5. The precision filtration device for heparin sodium extract according to claim 1, characterized in that: A temperature sensor (13) is installed inside the heating and stirring tank (4).