A tunable constant-current interventional electrocoagulation device

Abstract

The utility model discloses a tunable constant current interventional electric coagulation equipment, including display screen, current regulation button, tunable constant current electric coagulation equipment, interventional medical guide wire interface and medical guide wire, can coordinate constant current electric coagulation equipment including battery, power module, high frequency arbitrary waveform generating module, constant current output module, high frequency arbitrary waveform generating module includes digital control module and frequency synthesis module, and constant current output module includes current sampling circuit, constant current module. The utility model through microcontroller flexible configuration output waveform's amplitude and frequency, tunable output 1~37.5MHz's high frequency alternating current, realize 0~3mA's weak alternating current constant current output, satisfy 100's step range of muA, expand the electric coagulation equipment output constant current alternating current's ability, improved the step precision of output weak current, avoided the nerve reflex reaction that traditional electric coagulation treatment scheme in direct current signal to brain hemangioma class disease carries out electric coagulation treatment when causes.

Description

Technical Field

[0001] This utility model belongs to the field of medical electronic equipment technology, and in particular relates to an adjustable constant current interventional electrocoagulation device. Background Technology

[0002] Intravascular electrocoagulation involves passing an electric current through a metal device inserted into an artery or aneurysm cavity, simulating the reversal of the vascular intima potential to attract negatively charged blood components, thereby forming a thrombus locally and occluding the blood vessel or aneurysm cavity.

[0003] Currently, commonly used endovascular interventional treatments in clinical practice include simple coil embolization, balloon / stent-assisted coil embolization, and covered stent / blood diversion device placement. These methods are costly in terms of consumables and cannot effectively treat microvessels. Compared to traditional treatment methods, microwire electrocoagulation is simpler to perform, more cost-effective, and can treat microvessels.

[0004] Current microwire electrocoagulation treatment protocols are mainly focused on laboratory research, employing weak direct current for electrocoagulation. The electrocoagulation equipment used in these studies cannot support real-time adjustment of current frequency and intensity, and it is difficult to provide high-frequency alternating current. This limits the integrity of the experiments, and the direct current can trigger neural reflexes in animals, leading to experimental failure. Therefore, there is an urgent need for a flexible, portable interventional electrocoagulation device that can generate frequency-tunable and intensity-controllable alternating current to meet the needs of experimental research. Summary of the Invention

[0005] In view of this, the present invention aims to overcome the shortcomings of the above-mentioned problems in the prior art and proposes an adjustable constant current intervention electrocoagulation device.

[0006] To achieve the above objectives, the technical solution of this utility model is implemented as follows:

[0007] The first aspect of this utility model provides a tunable constant current electrocoagulation device, which can tunably output high-frequency AC power from 1 to 37.5 MHz, realize a weak AC constant current output from 0 to 3 mA, and meet the step range of 100 μA.

[0008] The second aspect of this utility model provides a tunable constant current interventional electrocoagulation device, including the above-mentioned tunable constant current electrocoagulation device, an interventional medical guidewire interface, and a medical guidewire;

[0009] The tunable constant current electrocoagulation device includes a battery, a power module, a high-frequency arbitrary waveform generation module, and a constant current output module. The battery is connected to the power module, and the power module is connected to both the high-frequency arbitrary waveform generation module and the constant current output module. The high-frequency arbitrary waveform generation module is connected to the constant current output module. The interventional medical guidewire interface is used to connect the constant current output module and the medical guidewire.

[0010] The high-frequency arbitrary waveform generation module includes a digital control module and a frequency synthesis module. The digital control module is connected to the frequency synthesis module. The digital control module includes a microcontroller. The frequency synthesis module includes a DDS circuit, a filter circuit, and a feedback amplifier circuit. The DDS circuit is connected to the filter circuit, and the filter circuit is connected to the feedback amplifier circuit.

[0011] The constant current output module includes a current sampling circuit and a constant current module;

[0012] The medical guidewire serves as a carrier of electric current and is used to puncture and enter the patient's blood vessels.

[0013] Furthermore, the power module includes a voltage conversion circuit for converting the battery voltage into a target voltage for other modules;

[0014] The voltage conversion circuit includes multiple power rails, namely the first power rail, the second power rail, the third power rail, the fourth power rail and the fifth power rail, which respectively generate the +15V, +5V, +12V, -15V and -12V voltages required by the target module.

[0015] The first power rail input is powered by a battery and generates a +15V voltage through a DC step-down circuit.

[0016] The input voltage of the second power rail is the output voltage of the first power rail, and the input voltage is converted to +5V through a step-down circuit;

[0017] The input voltage of the third power rail is the output voltage of the first power rail, and the input voltage is converted to +12V through a step-down circuit.

[0018] The fourth power rail voltage input is the voltage output of the second power rail, and the input voltage is converted to -15V output through a polarity reversal circuit;

[0019] The fifth power rail voltage input is the voltage output of the fourth power rail, and the input voltage is converted to -12V output through a step-down circuit.

[0020] Furthermore, it also includes a display screen and a current adjustment button. The display screen is a TFT display screen, which is connected to a digital control module, and the current adjustment button is also connected to the digital control module.

[0021] Furthermore, the microcontroller is used to communicate with the frequency synthesis module and control the output waveform, signal frequency, and signal amplitude of the frequency synthesis module.

[0022] Furthermore, the DDS circuit controls the output frequency and amplitude of an analog signal through a digital signal. This signal is used to control the output AC frequency to be adjustable between 1 and 37.5 MHz. The filter circuit is used for high-frequency filtering, and the feedback amplifier circuit uses in-phase amplification to adjust the output signal amplitude.

[0023] Furthermore, the filtering circuit employs a sixth-order passive Butterworth LC low-pass filter.

[0024] Furthermore, the current sampling circuit is used to detect the magnitude of the output current and convert the output current into a voltage value, which is then sent to the digital control module.

[0025] Furthermore, the constant current module is used to generate AC constant current.

[0026] Furthermore, when the digital control module is configured to output an AC signal via the frequency synthesis module, the constant current module can output a weak AC current in the range of 0–3 mA with a step accuracy of 100 μA.

[0027] Compared with existing technologies, the adjustable constant current interventional electrocoagulation device of this utility model has the following advantages:

[0028] The interventional electrocoagulation device of this invention adopts a modular circuit structure, which is small in size and easy to carry.

[0029] To address the shortcomings of existing experimental studies that use batteries as electrocoagulation devices and thus cannot adjust the current frequency and intensity, this invention utilizes a high-frequency arbitrary waveform generation module and a constant current output module to adjust the frequency and intensity of the output current in real time, thereby improving the flexibility and precision of the electrocoagulation device and compensating for the lack of experimental data due to equipment limitations.

[0030] This invention allows for flexible configuration of the amplitude and frequency of the output waveform via a microcontroller, enabling the tunable output of high-frequency AC power from 1 to 37.5 MHz. It achieves a weak AC constant current output of 0 to 3 mA, meeting a step range of 100 μA. This expands the ability of electrocoagulation equipment to output constant current AC power, improves the step accuracy of weak current output, and avoids the nerve reflex reactions caused by DC signals in traditional electrocoagulation treatment for cerebral aneurysms. Attached Figure Description

[0031] The accompanying drawings, which form part of this utility model, are used to provide a further understanding of the utility model. The illustrative embodiments of the utility model and their descriptions are used to explain the utility model and do not constitute an undue limitation of the utility model. In the drawings:

[0032] Figure 1 This embodiment provides an architecture diagram of a tunable constant current interventional electrocoagulation device.

[0033] Figure 2 This embodiment provides a block diagram of a multi-power rail architecture for a tunable constant current interventional electrocoagulation device.

[0034] Figure 3 This embodiment provides a circuit diagram of a power supply module for an adjustable constant current interventional electrocoagulation device.

[0035] Figure 4 This embodiment provides a circuit structure diagram of a digital control module for a tunable constant current interventional electrocoagulation device.

[0036] Figure 5 This embodiment provides a circuit diagram of a frequency synthesis module for a tunable constant current interventional electrocoagulation device.

[0037] Figure 6 This embodiment provides a circuit diagram for current sampling in an adjustable constant current interventional electrocoagulation device.

[0038] Figure 7 This embodiment provides a circuit diagram of a constant current module for an adjustable constant current interventional electrocoagulation device. Detailed Implementation

[0039] It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0040] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0041] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0042] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0043] In one embodiment, such as Figure 1 As shown, a schematic diagram of an tunable constant current interventional electrocoagulation device is provided, including a display screen, a current adjustment button, an tunable constant current electrocoagulation device, an interventional medical guidewire interface, and a medical guidewire. The display screen is a TFT display screen, and the current adjustment button is a mechanical button. The interventional electrocoagulation device mainly includes a battery, a power module, a high-frequency arbitrary waveform generation module, a constant current output module, an interventional medical guidewire interface, and a medical guidewire.

[0044] In the above embodiments, the display screen is a conventional TFT display screen, the current adjustment button is a mechanical button, and the battery is a conventional instrument dry cell battery connected in series to the power module. The power module converts the battery voltage to power the high-frequency arbitrary waveform generation module and the constant current output module. The high-frequency arbitrary waveform generation module includes a digital control module and a frequency synthesis module. The digital control module includes a microcontroller chip for controlling the output waveform, signal frequency, and signal amplitude of the frequency synthesis module. The frequency synthesis module includes a DDS circuit, a filter circuit, and a feedback amplifier circuit. The DDS circuit can control the output frequency and amplitude of an adjustable analog signal through digital signals. The filter circuit is used for high-frequency filtering, and the feedback amplifier circuit uses in-phase amplification to adjust the output signal amplitude. The constant current output module includes a current sampling circuit and a constant current module. The current sampling circuit is used to detect the output current magnitude and convert the output current into a voltage value, which is then sent to the digital control module. The constant current module is used to generate a weak AC / DC current. An interventional medical guidewire interface is used to connect the constant current output module and the medical guidewire. The medical guidewire, as a current carrier, is used for puncture into the patient's blood vessel.

[0045] In one embodiment, such as Figure 2 The diagram shows a multi-rail power supply architecture. The first power rail input is powered by a battery, as shown below. Figure 3The power module shown converts the battery voltage into the voltage required by each module in the device. The battery voltage, after being filtered by a capacitor, is connected to the input pin of chip U25. The input voltage is then output as +15V via a DC-DC step-down circuit. The second power rail input voltage is the +15V output voltage of the first power rail. This +15V voltage is connected to the input pin of chip U9, generating +5V. The third power rail input voltage is the +15V output voltage of the first power rail. This is connected to the input pin of chip U30 and converted to +12V via a step-down circuit. The fourth power rail input voltage is the output voltage of the second power rail. This +5V voltage is connected to the input pin of chip U26. By adjusting the resistance ratio of the feedback circuit, the theoretical output voltage value is calculated. This +5V is then converted to -15V via a polarity reversal circuit. The fifth power rail input voltage is the -15V output of the fourth power rail. This -15V voltage is connected to the input pin of chip U29 and converted to -12V via a step-down circuit.

[0046] The power supply module of this utility model is designed to adapt to the voltage standards of different subsequent modules. In order to generate the positive and negative voltage values ​​required by the high-frequency arbitrary waveform generation module and the constant current output module, this embodiment adopts a positive power input method, and obtains the required positive and negative voltage values ​​through multiple power rails. The single-pole power supply effectively improves the portability and flexibility of the device.

[0047] In one embodiment, such as Figure 4 The digital control module shown includes a microcontroller chip used to configure the output waveform, signal frequency, and signal amplitude of the frequency synthesis module. The microcontroller within the digital control module provides two configuration methods for the frequency synthesis module: the first method involves real-time modification via a host computer, and the second method stores the configuration information in internal storage and allows manual modification via a current adjustment button.

[0048] In one embodiment, such as Figure 5 The frequency synthesis module shown includes a DDS circuit, a filter circuit, and a feedback amplifier circuit. The DDS circuit can control the output frequency and amplitude of an analog signal through digital signals. The filter circuit is used for high-frequency filtering, and the feedback amplifier circuit uses in-phase amplification to adjust the output signal amplitude.

[0049] In the above embodiment, the DDS circuit is built around U11 as the peripheral circuit. Pin 1 of the DDS chip is connected in series with resistor R132 to the DAC output pin of the microcontroller. The microcontroller changes the output current of U11 by changing the DAC output voltage. Pin 8 of the DDS chip is connected to the clock output pin of the U12 crystal oscillator. U12 is an active crystal oscillator that provides an external reference clock for the DDS chip. Pins 12-16 are the serial protocol data ports of the DDS chip, connected to the microcontroller for configuring the DDS chip. Pins 19 and 20 are the output pins of the DDS chip, which are connected to the feedback amplifier circuit after passing through the filtering circuit and then to the connector.

[0050] In the previous embodiment, the filtering circuit is used to perform low-pass filtering on the DDS chip output signal. A sixth-order passive Butterworth LC low-pass filter, composed of resistors and inductors, is used to filter high-order noise in the output signal. The feedback amplifier circuit is used to adjust the amplitude of the DDS chip output signal. The DDS chip output signal is limited by the chip itself and cannot adapt to the input voltage range of the constant current output module. Utilizing the non-inverting amplification structure of the feedback amplifier circuit, the positive input terminal of the amplifier is connected to the signal output terminal of the DDS chip, and the 0.6V voltage output from pin 2 of the DDS chip is used as the reference voltage for feedback. By changing the voltage at pin 1 of the DDS chip through the digital control module, the voltage range of the feedback amplifier circuit output signal is changed for signal conditioning, providing a suitable signal amplitude for the constant current output module.

[0051] In one embodiment, such as Figure 6 The current sampling circuit shown is used to detect the output current magnitude and convert it into a voltage value, which is then sent to the digital control module. The current sampling circuit consists of a precision sampling resistor and a current sensing amplifier. Resistor R7 is the precision sampling resistor. The two ends of resistor R7 are connected to the positive and negative input pins of the current sensing amplifier U4, respectively. Current flowing through the sampling resistor creates a voltage difference, which the current sensing amplifier samples. This sampled voltage difference is then sent to the digital control module via a serial port protocol. The data control module calculates the sampled information and transmits the result to the display screen.

[0052] In one embodiment, Figure 7 The constant current module shown can be used to generate both AC and DC constant current. Figure 7 In the circuit, the input signal is input to the negative input terminal of the operational amplifier U2 through the H3 connector in series with resistors R6 and R3. The operational amplifier U3 acts as a follower, and the AC / DC signal output from pin 6 of U2 is connected to the H4 connector through resistor R2.

[0053] In the above embodiments, in order to better demonstrate the frequency tuning and intensity control of high-frequency alternating current of this utility model, the tuning process and current step control will be further described.

[0054] The frequency tuning process of high-frequency alternating current is as follows: Figure 4 The digital control module shown is configured via the SPI serial port protocol on pins PA5-7. Figure 5 The register values ​​of the DDS chip are configured differently to output a high-frequency AC signal ranging from 1 to 37.5 MHz. The high-frequency AC signal output by the DDS chip is connected to socket CN3. Figure 7 The socket H3 is connected to the negative input terminal of operational amplifier U2 via resistors R6 and R3. The high-frequency AC signal passes through the two-stage negative feedback amplification circuit of U2 and U3, and a high-frequency AC power of 1 to 37.5MHz is output from pin 6 of U2.

[0055] The AC current intensity and step control are as follows: Figure 4 The digital control module shown adjusts the voltage value of the internal DAC output on pin PA4 by changing the value of its internal register. This signal is connected to... Figure 5 One side of the medium resistor R132. Figure 5 Pin 19 of the DDS outputs an AC signal. The voltage value output by the DAC controls the swing of this AC signal between 0 and 0.6V. The AC signal output by the DDS is amplified to between 0 and 1.2V by the feedback amplifier circuit of U14. The AC signal then passes through... Figure 7 The constant current module circuit shown provides a weak AC current of 0–3 mA, which is the ratio of the AC signal swing to the resistance R2. At this point, the internal DAC has a precision of 12 bits and a swing range of 0.6V, resulting in an output AC current step precision of 0.6 / 2. 12 It is approximately 100 μA.

[0056] This invention can also change the AC / DC output mode, which is achieved through the following control: the configuration information of the frequency synthesis module controls the frequency synthesis module to output an AC signal, and the constant current module follows by outputting an AC current, the intensity of which is controlled by resistor R2 and input voltage; the digital control module changes the configuration information of the frequency synthesis module, controls the frequency synthesis module to output a DC signal, and the constant current module follows by outputting a DC current, the intensity of which is controlled by resistor R2 and input voltage.

[0057] In one embodiment, the medical guidewire interface includes a return port and a four-pin Remo connector. One end of the Remo connector is connected to the output current interface of the constant current output module, and the other end is connected to the medical guidewire. The return port uses copper wire and clips to connect to another medical guidewire, serving as the current loop path. The medical guidewire is made of titanium alloy, with a tip diameter of 0.4 mm and a tail diameter of 0.7 mm. In use, the medical guidewire serves as the current carrier for puncture into the patient's blood vessel.

[0058] In experiments involving electrocoagulation therapy of blood vessels in mice, the device described in this application was used to apply high-frequency weak alternating currents of 1MHz–1mA, 17.5MHz–1.5mA, and 37.5MHz–2.5mA, as well as high-frequency weak direct currents of 1MHz–1mA, 17.5MHz–1.5mA, and 37.5MHz–2.5mA. It was found that regardless of whether it was AC or DC, the current intensity only affected the speed of thrombus formation. When DC was applied, the mice exhibited slight or obvious knee-jerk reflexes, while no reflex was observed when AC was applied. Therefore, the device described in this application, which can tune to output high-frequency weak alternating currents of 1–37.5MHz and 0–3mA, avoids the neurological reflex reactions caused by DC signals in traditional electrocoagulation therapy for cerebral aneurysms.

[0059] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A tunable constant current interventional electrocoagulation device, characterized in that: This includes tunable constant current electrocoagulation equipment, interventional medical guidewire interfaces, and medical guidewires; The tunable constant current electrocoagulation device includes a battery, a power module, a high-frequency arbitrary waveform generation module, and a constant current output module. The battery is connected to the power module, and the power module is connected to both the high-frequency arbitrary waveform generation module and the constant current output module. The high-frequency arbitrary waveform generation module is connected to the constant current output module. The interventional medical guidewire interface is used to connect the constant current output module and the medical guidewire. The high-frequency arbitrary waveform generation module includes a digital control module and a frequency synthesis module. The digital control module is connected to the frequency synthesis module. The digital control module includes a microcontroller. The frequency synthesis module includes a DDS circuit, a filter circuit, and a feedback amplifier circuit. The DDS circuit is connected to the filter circuit, and the filter circuit is connected to the feedback amplifier circuit. The constant current output module includes a current sampling circuit and a constant current module; The medical guidewire serves as a carrier of electric current and is used to puncture and enter the patient's blood vessels.

2. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The tunable constant current electrocoagulation device can output high-frequency AC power from 1 to 37.5 MHz, achieving a weak AC constant current output of 0 to 3 mA, and meeting the 100 μA step range.

3. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The power module includes a voltage conversion circuit, which is used to convert the battery voltage into a target voltage for other modules. The voltage conversion circuit includes multiple power rails, namely the first power rail, the second power rail, the third power rail, the fourth power rail and the fifth power rail, which respectively generate the +15V, +5V, +12V, -15V and -12V voltages required by the target module. The first power rail input is powered by a battery and generates a +15V voltage through a DC step-down circuit. The input voltage of the second power rail is the output voltage of the first power rail, and the input voltage is converted to +5V through a step-down circuit; The input voltage of the third power rail is the output voltage of the first power rail, and the input voltage is converted to +12V through a step-down circuit. The fourth power rail voltage input is the voltage output of the second power rail, and the input voltage is converted to -15V output through a polarity reversal circuit; The fifth power rail voltage input is the voltage output of the fourth power rail, and the input voltage is converted to -12V output through a step-down circuit.

4. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: It also includes a display screen and a current adjustment button. The display screen is a TFT display screen and is connected to a digital control module. The current adjustment button is also connected to the digital control module.

5. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The microcontroller is used to communicate with the frequency synthesis module and control the output waveform, signal frequency, and signal amplitude of the frequency synthesis module.

6. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The DDS circuit controls the output frequency and amplitude of the analog signal through digital signal control. The filter circuit is used for high-frequency filtering, and the feedback amplifier circuit uses in-phase amplification to adjust the output signal amplitude.

7. The adjustable constant current interventional electrocoagulation device according to claim 6, characterized in that: The filtering circuit uses a sixth-order passive Butterworth LC low-pass filter.

8. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The current sampling circuit is used to detect the magnitude of the output current and convert the output current into a voltage value, which is then sent to the digital control module.

9. The adjustable constant current interventional electrocoagulation device according to claim 1, characterized in that: The constant current module is used to generate AC constant current.

10. A tunable constant current interventional electrocoagulation device according to claim 1, characterized in that: When the digital control module is configured to output an AC signal from the frequency synthesis module, the constant current module outputs a weak AC current.

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