A gel dialysis device
By using a rack and dialysis screen in the dialysis device, the problems of easy damage to dialysis membrane bags and gel swelling are solved, achieving stable dialysis and controllable gel production, suitable for small-batch or large-volume production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- MEIYAN SPACE (HEBEI) BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-05-27
- Publication Date
- 2026-06-12
AI Technical Summary
In traditional dialysis methods, dialysis bags are prone to floating or being torn by the agitator, resulting in gel spoilage. Furthermore, when cross-linked polymer gels expand, they can easily break open the clamps of the dialysis bag, causing gel loss.
A gel dialysis apparatus is used, which includes a reaction vessel, a shelf, a dialysis screen, and an electric stirrer. The dialysis screen is fixed to the shelf by a hook, and the electric stirrer is used to stir the gel to prevent the membrane bag from floating or breaking. The gel expansion is controlled by the squeezing action of the dialysis screen.
It effectively prevents damage to dialysis membrane bags during stirring, ensures the removal of cross-linking agents, and controls gel volume and weight, making it suitable for small-batch or large-volume production.
Smart Images
Figure CN224345690U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biomedical material manufacturing equipment, specifically to a gel dialysis device. Background Technology
[0002] In the process of preparing cross-linked polymer gels by cross-linking polymer compounds with chemical cross-linking agents, dialysis is often used to remove excess cross-linking agents. CN108395552B discloses a method for preparing monophase cross-linked sodium hyaluronate gel, specifically: sodium hyaluronate alkaline treatment - 1,4-butanediol diglycidyl ether (BDDE) cross-linking reaction - dialysis with dialysate - preliminary granulation - colloid mill granulation. CN115279330A discloses a cross-linked HA-collagen hydrogel as a dermal filler, which uses 1-ethyl-3-(N,N'-dimethylaminopropyl)carbodiimide (EDC) / N-hydroxysuccinimide (NHS) to prepare the cross-linked HA-collagen hydrogel, and removes EDC / NHS by dialysis.
[0003] The traditional dialysis method involves filling a dialysis bag made of a semi-permeable membrane with gel, clamping the two ends of the dialysis bag with clips, immersing the dialysis bag in the dialysis solution, and using a magnetic stirrer or a stirring paddle to continuously stir the dialysis solution for dialysis. The dialysis solution is then replaced every once in a while.
[0004] The problems with this dialysis method are: the dialysis membrane bag is prone to floating or being torn by the stirring paddle during the stirring dialysis process, resulting in the waste of the gel; due to the expansion of the gel, the clamp of the dialysis membrane bag is easily stretched open, resulting in the waste of the gel. Summary of the Invention
[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a gel dialysis device that can effectively prevent dialysis membrane bags from floating, being torn, or expanding and becoming unusable.
[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows:
[0007] A gel dialysis apparatus, characterized in that it includes a reaction vessel, a shelf, a dialysis screen, and an electric stirrer.
[0008] The shelf consists of N circular rings spaced apart from top to bottom and M uprights fixed to each circular ring at intervals along the circumference. N is a positive integer greater than or equal to 1, and M is a positive integer greater than or equal to 2. The shelf is placed inside the reaction tank, and the uprights are parallel to the tank wall of the reaction tank. The axis of the shelf coincides with the axis of the reaction tank.
[0009] The shelf is equipped with hooks, and the dialysis screen is fixed to the shelf by the hooks and placed inside the shelf.
[0010] The dialysis screen includes a base plate with an opening at the top and a top cover, and the base plate and the top cover are provided with screen holes;
[0011] The electric stirrer is either a magnetic stirrer or a mechanical stirrer.
[0012] Furthermore, the bottom of the reaction tank is provided with a water outlet, and the top of the reaction tank is provided with a top cover. The top cover is composed of two parts, left and right, and is rotatably installed on the top of the reaction tank. A round hole is left in the center of the top cover, and the stirring paddle passes through the round hole of the top cover and is placed at the axial position of the shelf.
[0013] Furthermore, N and M are positive integers greater than or equal to 3, the electric stirrer is a mechanical stirrer, and the stirring paddle of the mechanical stirrer is positioned at the axial position of the shelf from the top of the reaction tank.
[0014] Furthermore, the shelf is made of stainless steel, and the uprights are welded and fixed to the ring.
[0015] Furthermore, one side of the top cover is rotatably mounted on the chassis, and the other side of the top cover is provided with a fixing device corresponding to the chassis, for fixing the top cover to the chassis.
[0016] Furthermore, the dialysis screen is provided with a hollow cylinder, and the dialysis screen is fixed to the hook through the hollow cylinder.
[0017] Furthermore, the dialysis screen is provided with two hollow cylinders, and the shelf is provided with two corresponding hooks.
[0018] Furthermore, the dialysis screen is rectangular in shape, with two hollow cylinders arranged along the long side of the cuboid. Two corresponding hooks on the shelf are arranged axially. When the dialysis screen is hung on the hooks, the long side of the dialysis screen is parallel to the axial direction of the shelf.
[0019] Furthermore, the hollow cylinder is disposed on the side of the dialysis screen base plate.
[0020] Furthermore, the two hooks corresponding to the shelf are respectively located on the upright and on the ring.
[0021] Compared with the prior art, the beneficial effects of this utility model are:
[0022] 1. The gel dialysis device of this utility model, through the setting of the shelf and dialysis screen, places the gel wrapped in the dialysis membrane bag in the dialysis screen, so that it will not be broken by the magnet or stirring paddle during the stirring dialysis process.
[0023] 2. When the cross-linked polymer gel expands to contact the inner wall of the dialysis screen, it will compress the inner wall and stop increasing in volume. The dialysis membrane bag clamp will not be stretched open, thus avoiding the problem of the gel expanding and causing it to be scrapped.
[0024] 3. By controlling the amount of material, the size of the dialysis sieve, and the molecular retention of the semi-permeable membrane, it is possible to ensure both the effective removal of the cross-linking agent and the controllability of the final volume and weight of the gel.
[0025] 4. Selectively setting multiple dialysis screens on the shelf allows for both small-batch preparation and large-scale production. Attached Figure Description
[0026] Figure 1 This is a schematic diagram of the disassembled structure of the present invention, which does not include a dialysis screen;
[0027] Figure 2 This is a schematic diagram of the dialysis screen of this utility model in a closed state;
[0028] Figure 3 This is a schematic diagram of the dialysis screen of this utility model in the open state;
[0029] Figure 4 This is a schematic diagram of the structure of the reaction tank of this utility model, including the top cover and the water outlet;
[0030] Figure 5 This is a top view of the combination of the storage rack and dialysis screen of this utility model;
[0031] In the diagram: 1. Reaction tank; 11. Outlet; 12. Top cover; 13. Round hole; 2. Shelf; 21. Ring; 22. Upright pole; 23. Hook; 3. Dialysis sieve; 31. Base plate; 32. Top cover; 33. Sieve hole; 34. Fixing device; 35. Hollow cylinder; 4. Electric stirrer; 41. Stirring paddle. Detailed Implementation
[0032] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.
[0033] To make the objectives and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments.
[0034] like Figures 1-3As shown, this utility model provides a gel dialysis device, including a reaction vessel 1, a shelf 2, a dialysis screen 3, and an electric stirrer 4.
[0035] The shelf 2 consists of N rings 21 spaced apart from top to bottom and M uprights 22 fixed to each ring 21 at intervals along the circumference. N is a positive integer greater than or equal to 1 and M is a positive integer greater than or equal to 2. The shelf 2 is placed inside the reaction tank 1, and the uprights 22 are parallel to the tank wall of the reaction tank 1. The axis of the shelf 2 coincides with the axis of the reaction tank 1.
[0036] The shelf 2 is equipped with hooks 23, and the dialysis screen 3 is fixed to the shelf 2 by the hooks 23 and placed in the inner perimeter of the shelf 2; the dialysis screen 3 includes a base 31 with an opening at the top and a top cover 32, and the base 31 and the top cover 32 are provided with screen holes 33; the electric stirrer 4 is a magnetic stirrer or a mechanical stirrer.
[0037] The working principle of the gel dialysis device provided by this utility model is as follows:
[0038] The cross-linked polymer gel, after the cross-linking reaction is complete, is placed into a dialysis membrane bag, and both ends of the dialysis membrane bag are clamped. The top cover 32 of the dialysis screen 3 is opened and placed inside the base plate 31, and then the top cover 32 is closed. At this time, the gel is wrapped in the dialysis membrane bag and placed inside the dialysis screen 3, and the gel will not leak from the dialysis membrane bag. Multiple dialysis screens 3 can be set for large-scale dialysis gel production to meet the needs of industrial production. Multiple dialysis screens 3 are fixed to the shelf 2 by multiple corresponding hooks 23 and placed inside the shelf 2. Add dialysis fluid into the reaction vessel 1 and ensure that the surface of the dialysis fluid completely covers the dialysis screens 3. Place the magnetic stirrer or stirring paddle 41 of the electric stirrer 4 at the axial position of the rack 2 from above and start the electric stirrer 4 to stir, so that the dialysis fluid is in uniform contact with each dialysis screen 3. The dialysis fluid enters the dialysis screen 3 through the sieve holes 33 on the base plate 31 and the top cover 32, and then dialyzes the unreacted chemical crosslinking agent in the crosslinked polymer gel through the dialysis membrane bag.
[0039] Compared to traditional dialysis methods, the gel dialysis device of this invention selectively allows water, small molecule crosslinking agents, and uncrosslinked polymers to pass freely. The gel, encased in the dialysis membrane bag, is located in the dialysis screen 3 and will not be broken by the magnetic force or stirring paddle 41 during the stirring dialysis process. When the crosslinked polymer gel expands to contact the inner wall of the dialysis screen 3, it will compress the inner wall, and the volume will no longer increase. The dialysis membrane bag clamp will not be opened, but the crosslinking agent can still be dialyzed out of the gel. By controlling the amount of material, the size of the dialysis screen, and the molecular retention of the semi-permeable membrane, it is possible to ensure both the effective removal of the crosslinking agent and the controllable final volume and weight of the gel. Selectively setting multiple dialysis screens 3 on the rack 2 allows for both small-scale preparation and mass production.
[0040] Furthermore, such as Figure 4 As shown, the bottom of the reaction tank 1 is provided with a water outlet 11, and the top of the reaction tank 1 is provided with a top cover 12. The top cover 12 is composed of two parts, left and right, and is rotatably installed on the top of the reaction tank 1. A round hole 13 is left in the center of the top cover 12, and the stirring paddle 41 passes through the round hole 13 of the top cover 12 and is placed at the axial position of the shelf 2.
[0041] In industrial production, reaction vessel 1 has a relatively large volume, possibly 50L. An outlet 11 is located at the bottom of reaction vessel 1, and a valve is installed on outlet 11. Every so often, such as after 8 hours, the valve is opened to drain the old dialysate through outlet 11. Afterward, the valve is closed, and new dialysate is injected for the next round of dialysis.
[0042] The top cover 12 consists of two parts, left and right, installed on top of the reaction vessel 1, and can rotate along the circumference of the reaction vessel 1. This satisfies the need for opening and closing without affecting the electric stirrer 4 above. A circular hole 13 is provided in the center of the top cover 12. When the stirring paddle 41 is positioned at the axis of the shelf 2, it passes through the circular hole 13 of the top cover and connects to the motor of the electric stirrer 4. Since the dialysis process is relatively long, possibly up to 70 hours, the design of the top cover 12 ensures a closed dialysis environment, free from environmental contamination.
[0043] In addition, an outlet 11 can be provided on the top cover 12 to facilitate the injection of new dialysis fluid in a closed environment.
[0044] Furthermore, N and M are positive integers greater than or equal to 3. The number of rings 21 and uprights 22 can be set according to the required support strength of the shelf 2 during dialysis. For example... Figure 1 As shown, the shelf 2 has three rings 21 arranged in the upper, middle and lower sections, and then ten uprights 22 are fixed around the rings 21 to ensure that the shelf 2 can be stably placed in the reaction tank 1 and can firmly hook the dialysis box 3 while stirring.
[0045] Furthermore, the electric stirrer is a mechanical stirrer, with the stirring paddle positioned at the axial position of the shelf from the top of the reaction vessel. Mechanical stirrers are suitable for industrial production, while magnetic stirrers are more suitable for small-scale laboratory production.
[0046] Furthermore, the shelf 2 is made of stainless steel, and the upright 22 is welded and fixed to the ring 21, so that the upright 22 and the ring 21 are welded into a whole, which enhances the strength of the shelf 2.
[0047] Furthermore, such as Figure 2 and 3As shown, one side of the top cover 32 is rotatably mounted on the base 31, and the other side of the top cover 32 is provided with a fixing device 34 corresponding to the base 31, which is used to fix the top cover 32 to the base 31. With the setting of the fixing device 34, the gel wrapped in the dialysis membrane bag can be placed in the dialysis box 3, and during the dialysis process, the gel will not expand indefinitely due to water absorption and leak out of the dialysis membrane bag.
[0048] Furthermore, the dialysis box 3 is provided with a hollow cylinder 35, and the dialysis box 3 is fixed to the hook 23 by the hollow cylinder 35.
[0049] To increase stability, the dialysis box 3 is equipped with two hollow cylinders 35, and the shelf 2 is equipped with two corresponding hooks 23.
[0050] Furthermore, the dialysis screen 3 is rectangular in shape, with two hollow cylinders 35 arranged along the long side of the cuboid, and two corresponding hooks 23 on the shelf 2 arranged along the axial direction. When the dialysis screen 3 is hung on the hooks 23, the long side of the dialysis screen 3 is parallel to the axial direction of the shelf 2.
[0051] Furthermore, the hollow cylinder 35 is disposed on the side of the base plate 31 of the dialysis screen 3.
[0052] Because the dialysis screen 3 is rectangular, the gel inside the dialysis screen 3 is also rectangular. The long side of the dialysis screen 3 is parallel to the axis of the shelf 2, and the side of the base 31 of the dialysis screen 3 is close to the inner wall of the shelf 2, thus arranging the largest surface of the dialysis screen 3 radially. Figure 5 As shown, stirring during dialysis can further promote the exchange of substances between the dialysate and the gel, thereby improving dialysis efficiency.
[0053] Furthermore, the two corresponding hooks 23 on the shelf 2 are respectively set on the upright 22 and the ring 21, as detailed in the following figure. Figure 1 A schematic diagram of the shelving unit.
[0054] Based on the size of the dialysis screen 3 and the number of dialysis screens 3 that can be placed in the reaction tank 1, multiple sets of hooks 23 corresponding to the dialysis screens 3 are set on the shelf 2. At the same time, in a set of hooks, one is set on the upright 22 and the other is set on the ring 21, which can distribute the load on the dialysis screen 3 on the upright 22 and make the dialysis screen 3 more stable.
[0055] Finally, it should be noted that the terms “comprising,” “including,” or any other variations thereof in this application are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0056] Although this application has been disclosed above through the description of specific embodiments, it should be understood that those skilled in the art can devise various modifications, improvements, or equivalents to this application within the spirit and scope of the appended solutions. Such modifications, improvements, or equivalents should also be considered to be included within the scope of protection claimed in this application.
Claims
1. A gel dialysis device, characterized in that, Includes reaction vessel, shelf, dialysis screen and electric stirrer; The shelf consists of N circular rings spaced apart from top to bottom and M uprights fixed to each circular ring at intervals along the circumference. N is a positive integer greater than or equal to 1, and M is a positive integer greater than or equal to 2. The shelf is placed inside the reaction tank, and the uprights are parallel to the tank wall of the reaction tank. The axis of the shelf coincides with the axis of the reaction tank. The shelf is equipped with hooks, and the dialysis screen is fixed to the shelf by the hooks and placed inside the shelf. The dialysis screen includes a base plate and a top cover with an opening at the top, and the base plate and the top cover are provided with screen holes; the electric stirrer is a magnetic stirrer or a mechanical stirrer.
2. The gel dialysis device according to claim 1, characterized in that, The reaction tank has a water outlet at the bottom and a top cover at the top. The top cover is composed of two parts, left and right, and is rotatably installed on the top of the reaction tank. A round hole is left in the center of the top cover, and the electric stirrer passes through the round hole of the top cover and is placed at the axial position of the shelf.
3. The gel dialysis apparatus according to claim 1, characterized in that, N and M are positive integers greater than or equal to 3, the electric stirrer is a mechanical stirrer, and the stirring paddle of the mechanical stirrer is positioned at the axial position of the shelf from the top of the reaction tank.
4. The gel dialysis apparatus according to claim 1, characterized in that, The shelf is made of stainless steel, and the uprights are welded and fixed to the ring.
5. The gel dialysis apparatus according to claim 1, characterized in that, One side of the top cover is rotatably mounted on the chassis, and the other side of the top cover is provided with a fixing device corresponding to the chassis, which is used to fix the top cover to the chassis.
6. The gel dialysis apparatus according to claim 1, characterized in that, The dialysis screen is provided with a hollow cylinder, and the dialysis screen is fixed to the hook through the hollow cylinder.
7. The gel dialysis apparatus according to claim 6, characterized in that, The dialysis screen has two hollow cylinders, and the shelf has two corresponding hooks.
8. The gel dialysis apparatus according to claim 7, characterized in that, The dialysis screen is rectangular in shape, with two hollow cylinders arranged along the long side of the cuboid. Two corresponding hooks on the shelf are arranged axially. When the dialysis screen is hung on the hooks, the long side of the dialysis screen is parallel to the axial direction of the shelf.
9. The gel dialysis apparatus according to claim 8, characterized in that, The hollow cylinder is disposed on the side of the bottom plate of the dialysis screen.
10. The gel dialysis apparatus according to claim 8, characterized in that, The shelf has two corresponding hooks, one on the upright and the other on the ring.