Pharmaceutical fermenter

Abstract

The utility model relates to biological pharmacy equipment technical field discloses a kind of fermentation tanks for pharmacy, including multiple support legs, the top of multiple support legs is uniformly fixedly connected with same mounting plate, the right side of the top of mounting plate is provided with stirring mechanism, the stirring mechanism is used to mix fermentation broth, the left side of the top of mounting plate is provided with heat exchange mechanism, the heat exchange mechanism is used to maintain the temperature of fermentation environment, the right side of the stirring mechanism is provided with sampling mechanism, the stirring mechanism includes tank body, the bottom of tank body is fixedly connected in the top right side of mounting plate, the top of tank body is fixedly connected with sterile respirator. In the utility model, through the layered design of three-stage impeller, cooperate spoiler to destroy rotating flow, realize the consideration cell protection and dissolved oxygen efficiency, solve the contradiction of high shear and low dissolved oxygen, prevent defoaming agent pollution and improve purity, avoid temperature stratification at the same time, guarantee fermentation process stability.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical equipment technology, and in particular to a fermenter for pharmaceutical use. Background Technology

[0002] Pharmaceutical fermenters are core equipment in the pharmaceutical industry for microbial fermentation and cell culture bioreactor processes. Their performance directly affects the quality, yield, and production cost of drugs. In the pharmaceutical field, the production of various drugs such as antibiotics, amino acids, vitamins, and vaccines all rely on fermentation processes. With the rapid development of the pharmaceutical industry, the technical requirements for fermenters are also increasing. Currently, stainless steel mechanically stirred fermenters are commonly used in antibiotic fermentation production, which achieve dissolved oxygen mass transfer through stirring paddles. However, traditional fermenters have bottlenecks in shear force control, heat transfer efficiency, and foam elimination.

[0003] A search revealed Chinese patent publication number CN217499232U, which discloses a pharmaceutical fermenter comprising a tank body, end caps, a servo motor, a stirring shaft, and inclined blade impellers. It also includes a scrubbing assembly, a linkage assembly, and a lifting assembly. The scrubbing assembly includes an annular brush, a linkage ring, and a linkage rod. The lifting assembly includes a reciprocating screw, a reciprocating slider, an upper push ring, a lower push ring, and a connecting column. The upper and lower push rings respectively abut against the two sides of the linkage ring. The reciprocating slider is fixed to the upper push ring, and the reciprocating screw passes through both the upper and lower push rings. The linkage assembly includes a first one-way linkage fixed to the stirring shaft. The invention comprises a bearing, a first linkage gear sleeved and fixed on the outer ring of the first one-way bearing, and a second linkage gear sleeved and fixed on the reciprocating screw. The second linkage gear meshes with the first linkage gear. This invention improves the ease of cleaning the fermenter. The inclined blade agitator can reduce shear force and weaken the damage of shear force to mycelium. However, in actual use, the agitator tank has dead zones, which cause local dissolved oxygen to fall below the critical value. Excessive addition of defoamer in traditional defoaming devices will cause contamination of fermentation liquid components. Large-volume fermenters will exhibit temperature stratification, and the temperature gradient will cause the metabolic pathway of the microorganisms to deviate. Utility Model Content

[0004] To overcome the above deficiencies, this utility model provides a pharmaceutical fermenter, which aims to improve the problems of high shear force and low dissolved oxygen contradiction, temperature stratification in fermenters, and product purity reduction caused by defoamer contamination in the prior art.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a pharmaceutical fermenter, comprising multiple support legs, the top of which is fixedly connected to the same mounting plate; a stirring mechanism is provided on the top right side of the mounting plate for mixing fermentation broth; a heat exchange mechanism is provided on the top left side of the mounting plate for maintaining the temperature of the fermentation environment; a sampling mechanism is provided on the right side of the stirring mechanism; the stirring mechanism includes a tank body, the bottom of which is fixedly connected to the top right side of the mounting plate; a sterile respirator is fixedly connected to the top of the tank body; a motor is fixedly connected to the bottom of the tank body; a stirring shaft is fixedly connected to the output end of the motor; multiple three-stage impellers are fixedly connected to the outer wall of the stirring shaft; a feeding assembly is provided on the top right side of the tank body; and a discharging assembly is provided at the bottom front side of the outer wall of the tank body.

[0006] The above technical solution is as follows: First, the motor output drives the stirring shaft and multiple third-order impellers on the outer wall of the stirring shaft to rotate. The third-order impellers are divided into three layers. The lower layer blades rotate to generate a high-displacement axial flow, the middle layer blades generate a radial and axial composite flow field, and the upper layer is a semi-tube defoaming impeller responsible for eliminating foam. At the same time, the baffle plate breaks the rotating flow of the fermentation liquid during the stirring process, thereby improving the stirring and mixing efficiency.

[0007] As a further description of the above technical solution:

[0008] The heat exchange mechanism includes a refrigerant tank. The bottom of the refrigerant tank is fixedly connected to the top left side of the mounting plate. A centrifugal pump is fixedly connected to the rear side of the refrigerant tank. A first delivery pipe is connected to the top of the centrifugal pump. A spiral guide plate is fixedly connected to the inner side of the tank. A second delivery pipe is connected to the left end of the spiral guide plate. Temperature sensors are fixedly connected to the top right side of both the first and second delivery pipes.

[0009] The above technical solution involves: a refrigerant tank storing the heat exchange medium; a centrifugal pump outputting power to extract the heat exchange medium from the refrigerant tank; a spiral guide plate forming a flow channel with the inner wall of the tank; the heat exchange medium being transported to the flow channel via a first conveying pipe; the spiral guide plate guiding the heat exchange medium to flow along a spiral path and exchange heat with the fermentation liquid inside the tank; and a second conveying pipe returning the heat-exchanged medium to the refrigerant tank, forming a circulation loop; and a temperature sensor measuring the medium temperature and observing temperature changes.

[0010] As a further description of the above technical solution:

[0011] The feeding assembly includes a feeding port, the bottom of which is fixedly connected to the top right side of the tank body, and a sterile cap is rotatably connected to the top right side of the feeding port.

[0012] The above technical solution allows for easy addition of raw materials through the feed inlet, and the aseptic cap seals it, ensuring that the fermentation process takes place in a sterile environment.

[0013] As a further description of the above technical solution:

[0014] The discharge assembly includes a discharge port, the rear side of which is fixedly connected to the bottom front side of the outer wall of the tank, and a shut-off valve is rotatably connected inside the discharge port.

[0015] The above technical solution allows for the discharge of fermented liquid after fermentation. The discharge rate can be controlled by rotating the shut-off valve, enabling the opening and closing of the discharge process.

[0016] As a further description of the above technical solution:

[0017] The sampling mechanism includes a sampling valve, the left side of which is fixedly connected to the right side of the outer wall of the tank, a sampling tube is connected to the left side of the sampling valve, a collection bottle is fixedly connected to the bottom of the sampling valve, and a cleaning assembly is provided on the right side of the sampling valve.

[0018] The above technical solution involves extracting a portion of the fermentation broth from the tank using a sampling tube. The fermentation broth then enters the sampling valve through the sampling tube and is collected by the collection bottle. After the sample collection is completed, the sampling valve is closed, and then the cleaning process is performed using the cleaning assembly.

[0019] As a further description of the above technical solution:

[0020] The cleaning assembly includes a flushing port, the bottom of which is fixedly connected to the top of a sampling valve, and a drain pipe is connected to the right side of the sampling valve.

[0021] The above technical solution allows for cleaning operations when the sampling valve is closed. Cleaning fluid is introduced through the rinsing port and discharged through the drain pipe after cleaning is completed.

[0022] As a further description of the above technical solution:

[0023] Multiple baffles are fixedly connected to the inner wall of the tank, and the bottom of each baffle is fixedly connected to the bottom of the tank.

[0024] The above technical solution involves evenly distributing baffles on the inner wall of the tank to disrupt the swirling flow of the fermentation liquid during the stirring process.

[0025] As a further description of the above technical solution:

[0026] The right end of the first conveying pipe is fixedly connected to the left end of the spiral guide plate, and the left end of the second conveying pipe is connected to the right side of the refrigerant tank.

[0027] Through the above technical solution, the connection between conveying pipe one and spiral guide plate and conveying pipe two forms a heat exchange circulation structure, which uniformly exchanges the temperature of fermentation liquid inside the heat exchange tank.

[0028] This utility model has the following beneficial effects:

[0029] 1. In this invention, through the layered design of a three-stage impeller, the lower blades generate a low-shear axial flow to protect cells, the middle blades form a composite flow field to enhance dissolved oxygen transfer, and the baffle plate disrupts the rotating flow. At the same time, the sterile breather maintains a slight positive pressure inside the tank, and the upper semi-tube defoaming paddle breaks up the foam through centrifugal force. This achieves a balance between cell protection and dissolved oxygen efficiency, solves the contradiction between high shear and low dissolved oxygen, prevents defoamer contamination and improves purity, and avoids temperature stratification, ensuring the stability of the fermentation process.

[0030] 2. In this utility model, the heat exchange medium is stored in a refrigerant tank, and the medium is driven by a centrifugal pump to enter the spiral guide plate through the first delivery pipe. It exchanges heat with the fermentation broth along the spiral channel and then flows back through the second delivery pipe. The temperature sensor provides real-time feedback data to adjust the pump speed. This realizes that the spiral guide plate increases the heat exchange area, the spiral flow eliminates the temperature gradient, and the circulation system accurately controls the temperature, solving the problem of temperature stratification in large-volume fermenters and ensuring fermentation stability and product synthesis efficiency. Attached Figure Description

[0031] Figure 1 This is a front view of a pharmaceutical fermenter proposed in this utility model;

[0032] Figure 2 This is a perspective view of a pharmaceutical fermenter proposed in this utility model;

[0033] Figure 3 This is a cross-sectional view of a pharmaceutical fermenter proposed in this utility model;

[0034] Figure 4 This is a schematic diagram of the sampling tube of a pharmaceutical fermenter proposed in this utility model;

[0035] Figure 5 This is a schematic diagram of the structure of a centrifugal pump for a pharmaceutical fermenter proposed in this utility model.

[0036] Legend:

[0037] 1. Support leg; 2. Mounting plate; 3. Stirring mechanism; 301. Tank body; 302. Aseptic respirator; 303. Motor; 304. Stirring shaft; 305. Three-stage impeller; 306. Feeding assembly; 3061. Feed inlet; 3062. Aseptic cover; 307. Discharge assembly; 3071. Discharge outlet; 3072. Shut-off valve; 4. Heat exchange mechanism; 401. Refrigerant tank; 402. Centrifugal pump; 403. Conveying pipe one; 404. Spiral guide plate; 405. Conveying pipe two; 406. Temperature sensor; 5. Sampling mechanism; 501. Sampling valve; 502. Sampling tube; 503. Collection bottle; 504. Cleaning assembly; 5041. Flushing interface; 5042. Drain pipe; 6. Baffle plate. Detailed Implementation

[0038] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0039] Reference Figure 1 , Figure 2 and Figure 3This utility model provides an embodiment of a pharmaceutical fermenter, comprising multiple support legs 1 for supporting a fermentation device. The tops of the support legs 1 are all fixedly connected to the same mounting plate 2, which provides a platform for the fermentation device. A stirring mechanism 3 is located on the top right side of the mounting plate 2 for mixing the fermentation broth. A heat exchange mechanism 4 is located on the top left side of the mounting plate 2 for maintaining the temperature of the fermentation environment. A sampling mechanism 5 is located on the right side of the stirring mechanism 3, which can collect samples of the fermentation broth under aseptic conditions. Multiple baffles 6 are fixedly connected to the inner wall of the tank 301. The bottoms of the baffles 6 are all fixedly connected to the bottom of the tank 301. The baffles 6 are used to disrupt the swirling flow of the fermentation liquid and improve the mixing efficiency. The stirring mechanism 3 includes the tank 301, which is used to contain the fermentation liquid. The bottom of the tank 301 is fixedly connected to the top right side of the mounting plate 2. A sterile breather 302 is fixedly connected to the top of the tank 301 to maintain the air pressure balance inside the tank and filter the air to prevent contamination by bacteria. A motor 303 is fixedly connected to the bottom of the tank 301. The output end of the motor 303 is fixedly connected to a stirring shaft 304. The stirring shaft 304 is used to install a three-stage impeller 305. Multiple three-stage impellers 305 are fixedly connected to the outer wall of the stirring shaft 304. The motor 303 drives the stirring shaft 304 and the three-stage impellers 305 to rotate, stirring and mixing the fermentation liquid to ensure uniform distribution of the fermentation liquid. A feeding assembly 306 is provided on the top right side of the tank body 301. The feeding assembly 306 includes a feeding port 3061, which is responsible for feeding raw materials. The bottom of the feeding port 3061 is fixedly connected to the top right side of the tank body 301. A sterile cover 3062 is rotatably connected to the top right side of the inlet 3061. The sterile cover 3062 ensures that the inlet 3061 is in a sterile environment. A discharge assembly 307 is provided at the bottom front side of the outer wall of the tank 301. The discharge assembly 307 includes a discharge port 3071, which is used to discharge the fermented liquid after fermentation. The rear side of the discharge port 3071 is fixedly connected to the bottom front side of the outer wall of the tank 301. A shut-off valve 3072 is rotatably connected inside the discharge port 3071. The shut-off valve 3072 can control the opening and closing of the discharge, which facilitates the material discharge operation.

[0040] Specifically, firstly, multiple support legs 1 support the fermentation device. Then, the stirring mechanism 3 begins preparation, feeding raw materials into the tank 301 through the feed inlet 3061 at the top. During feeding, the sterile cover 3062 on the right side of the top of the feed inlet 3061 is rotated to open the feed inlet 3061. After feeding is complete, the sterile cover 3062 is closed to ensure that the feed inlet 3061 is in a sterile environment. After the raw materials enter the tank 301, the motor 303 at the bottom of the tank 301 is started. The output end of the motor 303 drives the stirring shaft 304 and multiple three-stage impellers 305 on the outer wall of the stirring shaft 304 to rotate. The system consists of three layers. The lower layer of blades rotates to generate a high-volume axial flow, protecting the cell integrity of the genetically engineered bacteria. The middle layer of blades generates a combined radial and axial flow field, enhancing the uniform distribution of the culture medium and dissolved oxygen. The upper layer is a semi-tube defoaming paddle that breaks up foam through centrifugal force during rotation. At the same time, multiple baffles 6 around the inner wall of the tank 301 disrupt the swirling flow of the fermentation broth, improving mixing efficiency and ensuring uniform distribution of the fermentation broth. During this process, the heat exchange mechanism 4 operates to maintain the fermentation environment temperature. The sterile breather 302 at the top of the tank 301 maintains the air pressure balance inside the tank and filters the air to prevent contamination by other microorganisms.

[0041] Reference Figure 2 , Figure 3 and Figure 5 The heat exchange mechanism 4 includes a refrigerant tank 401, which stores the heat exchange medium. The bottom of the refrigerant tank 401 is fixedly connected to the top left side of the mounting plate 2. A centrifugal pump 402 is fixedly connected to the rear side of the refrigerant tank 401, providing the circulation power for the heat exchange medium. The top of the centrifugal pump 402 is connected to a delivery pipe 403, which drives the heat exchange medium to circulate, realizing the delivery and circulation of the heat exchange medium. A spiral guide plate 404 is fixedly connected to the inner side of the tank body 301, which can increase the heat exchange area, guide the heat exchange medium to flow along the spiral path, and improve the heat exchange efficiency. The left side of the spiral guide plate 404... The first conveyor pipe 403 is connected to the second conveyor pipe 405, which sends the heat exchange medium back to the refrigerant tank 401. The right end of the first conveyor pipe 403 is fixedly connected to the left end of the spiral guide plate 404, and the left end of the second conveyor pipe 405 is connected to the right side of the refrigerant tank 401, which can form a circulation loop for the heat exchange medium, allowing the heat exchange medium to circulate and exchange heat within the tank 301. Temperature detectors 406 are fixedly connected to the top right side of the first conveyor pipe 403 and the top right side of the second conveyor pipe 405. The two temperature detectors 406 measure the temperature of the medium before and after heat exchange, respectively, to ensure accurate control of the fermentation temperature.

[0042] Specifically, when the heat exchange mechanism 4 is working, the refrigerant tank 401 first stores the heat exchange medium, and then the centrifugal pump 402 is started. The centrifugal pump 402 provides power to drive the heat exchange medium to flow out of the refrigerant tank 401, and is transported through the first conveying pipe 403 to the spiral guide plate 404 on the inner side of the tank body 301. There is a gap between the spiral guide plate 404 and the inner wall of the tank body 301 to form a guide channel. The spiral guide plate 404 increases the heat exchange area and guides the heat exchange medium to flow along the spiral path, and exchanges heat with the fermentation liquid in the tank. The medium after heat exchange is sent back to the right side of the refrigerant tank 401 through the second conveying pipe 405 to form a circulation loop. During this process, two temperature detectors 406 measure the medium temperature before heat exchange and the medium temperature after heat exchange, respectively. The speed of the centrifugal pump 402 or the medium temperature in the refrigerant tank 401 is adjusted according to the temperature data to ensure accurate control of the fermentation temperature.

[0043] Reference Figure 1 and Figure 4 The sampling mechanism 5 includes a sampling valve 501, which is used to connect to a sampling tube 502 and control the flow of sample liquid. The left side of the sampling valve 501 is fixedly connected to the right side of the outer wall of the tank 301, and the left side of the sampling valve 501 is connected to the sampling tube 502. The sampling tube 502 connects the tank 301 and the sampling valve 501, facilitating the flow of fermentation liquid into the sampling valve 501. A collection bottle 503 is fixedly connected to the bottom of the sampling valve 501 to collect the fermentation liquid flowing out of the sampling valve 501. For liquid samples, to facilitate sample testing and analysis, a cleaning assembly 504 is provided on the right side of the sampling valve 501. The cleaning assembly 504 includes a flushing port 5041, which is used to introduce external cleaning fluid. The bottom of the flushing port 5041 is fixedly connected to the top of the sampling valve 501. The sampling valve 501 is flushed through the flushing port 5041 to keep the sampling channel clean. A drain pipe 5042 is connected to the right side of the sampling valve 501 to discharge the waste liquid after cleaning.

[0044] Specifically, when sampling the fermentation broth is required, first confirm whether the fermentation process inside tank 301 is stable. If it is stable, use sampling tube 502 to collect a portion of the fermentation broth inside the tank. Then, open sampling valve 501. The fermentation broth flows through sampling tube 502 into sampling valve 501 and into collection bottle 503. After the sample collection is completed, close sampling valve 501 and then perform a cleaning operation. Introduce external cleaning fluid through flushing port 5041. The cleaning fluid flows through sampling valve 501 and flushes the residual fermentation broth into drain pipe 5042 to ensure the sampling channel is clean and ready for the next sampling.

[0045] Working principle: When the pharmaceutical fermenter is in operation, the sterile cover 3062 is opened, and the raw materials are fed into the tank body 301 through the feed inlet 3061. After feeding, the sterile cover 3062 is closed to ensure that the feed inlet 3061 is in a sterile environment. Then, the motor 303 is started, driving the stirring shaft 304 and the three-stage impeller 305 to rotate. The three-stage impeller 305 has three layers. The lower layer of blades generates a high-displacement axial flow to protect the cell integrity of the genetically engineered bacteria. The middle layer of blades generates a combined radial and axial flow field to enhance the uniformity of the culture medium and dissolved oxygen. The upper layer is a semi-tube defoaming paddle, which breaks up the foam by centrifugal force when rotating, avoiding the influence of adding chemical defoamers on the product. At this time, multiple baffles 6 fixedly connected around the inner wall of the tank 301 will disrupt the swirling flow of the fermentation liquid and improve the mixing efficiency. The sterile breather 302 fixedly connected to the top of the tank 301 can maintain the air pressure balance inside the tank and filter the air to prevent contamination by miscellaneous bacteria. When fermentation is completed, the shut-off valve 3072 rotatably connected inside the discharge port 3071 is opened, and the fermentation liquid is discharged from the discharge port 3071.

[0046] Furthermore, when the heat exchange mechanism 4 is working, the refrigerant tank 401 first stores the heat exchange medium, and then the centrifugal pump 402 on the rear side starts, driving the heat exchange medium to circulate through the top delivery pipe 403. The heat exchange medium enters the spiral guide plate 404 fixedly connected to the inner side of the tank 301 through the right end of the delivery pipe 403. There is a gap between the spiral guide plate 404 and the inner wall of the tank 301 to form a guide channel. The spiral guide plate 404 increases the heat exchange area and guides the heat exchange medium to flow along the spiral path to improve the heat exchange efficiency. Subsequently, the heat exchange medium is sent back to the refrigerant tank 401 through the second delivery pipe 405 to form a circulation loop, so that the heat exchange medium circulates in the tank 301 for heat exchange. At the same time, two temperature detectors 406 measure the temperature of the medium before and after heat exchange, respectively, and feed the data back to the control system to adjust the operating status of the centrifugal pump 402 to ensure the accuracy of fermentation temperature control.

[0047] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A pharmaceutical fermentation tank, comprising multiple support legs (1), characterized in that: The top of each of the multiple support legs (1) is fixedly connected to the same mounting plate (2). A stirring mechanism (3) is provided on the top right side of the mounting plate (2). The stirring mechanism (3) is used to mix the fermentation liquid. A heat exchange mechanism (4) is provided on the top left side of the mounting plate (2). The heat exchange mechanism (4) is used to maintain the temperature of the fermentation environment. A sampling mechanism (5) is provided on the right side of the stirring mechanism (3). The stirring mechanism (3) includes a tank (301), the bottom of which is fixedly connected to the top right side of the mounting plate (2), a sterile respirator (302) is fixedly connected to the top of the tank (301), a motor (303) is fixedly connected to the bottom of the tank (301), a stirring shaft (304) is fixedly connected to the output end of the motor (303), a plurality of three-stage impellers (305) are fixedly connected to the outer wall of the stirring shaft (304), a feeding assembly (306) is provided on the top right side of the tank (301), and a discharging assembly (307) is provided at the bottom of the front side of the outer wall of the tank (301).

2. The pharmaceutical fermenter according to claim 1, characterized in that: The heat exchange mechanism (4) includes a refrigerant tank (401), the bottom of which is fixedly connected to the top left side of the mounting plate (2). A centrifugal pump (402) is fixedly connected to the rear side of the refrigerant tank (401). A first delivery pipe (403) is connected to the top of the centrifugal pump (402). A spiral guide plate (404) is fixedly connected to the inner side of the tank body (301). A second delivery pipe (405) is connected to the left end of the spiral guide plate (404). Temperature detectors (406) are fixedly connected to the top right side of the first delivery pipe (403) and the top right side of the second delivery pipe (405).

3. A pharmaceutical fermenter according to claim 1, characterized in that: The feeding assembly (306) includes a feeding port (3061), the bottom of which is fixedly connected to the top right side of the tank body (301), and a sterile cap (3062) is rotatably connected to the top right side of the feeding port (3061).

4. A pharmaceutical fermenter according to claim 1, characterized in that: The discharge assembly (307) includes a discharge port (3071), the rear side of which is fixedly connected to the bottom of the front side of the outer wall of the tank (301), and a shut-off valve (3072) is rotatably connected inside the discharge port (3071).

5. A pharmaceutical fermenter according to claim 1, characterized in that: The sampling mechanism (5) includes a sampling valve (501), the left side of which is fixedly connected to the right side of the outer wall of the tank (301), the left side of which is connected to a sampling tube (502), the bottom of which is fixedly connected to a collection bottle (503), and the right side of which is provided with a cleaning assembly (504).

6. A pharmaceutical fermenter according to claim 5, characterized in that: The cleaning assembly (504) includes a flushing port (5041), the bottom of which is fixedly connected to the top of the sampling valve (501), and a drain pipe (5042) is connected to the right side of the sampling valve (501).

7. A pharmaceutical fermenter according to claim 1, characterized in that: Multiple baffles (6) are fixedly connected around the inner wall of the tank (301), and the bottom of each baffle (6) is fixedly connected to the bottom of the tank (301).

8. A pharmaceutical fermenter according to claim 2, characterized in that: The right end of the first conveying pipe (403) is fixedly connected to the left end of the spiral guide plate (404), and the left end of the second conveying pipe (405) is connected to the right side of the refrigerant tank (401).

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