A liquid chromatography column

Abstract

The utility model relates to liquid chromatography technical field especially is a kind of liquid chromatography column, including filler pipe, column cap, column body and drive assembly, and the both ends of filler pipe are respectively provided with one outer thread pipe;Column cap includes two, and column cap is provided with cylindrical cavity in, and the outer wall of column cap is annular array around its axis and is provided with the material guide pipe, gas blowing pipe, internal thread pipe and blow-off pipe communicated with cylindrical cavity, and the internal thread pipe on two column caps is respectively connected with the outer thread pipe on filler pipe corresponding side screw;Column body is set in cylindrical cavity and is attached with its inner wall, and the through-hole is set in column body along its radial direction, and sieve plate is set in the through-hole in close to one side opening portion;Drive assembly is set on column cap, and drive assembly rotates column body under working condition, to make the state of through-hole switch from the state of material guide pipe and internal thread pipe to blow-off pipe and gas blowing pipe communicated with each other.The utility model can quickly switch the orientation of the through-hole on column body, to facilitate the dredging and cleaning of sieve plate.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, and in particular to a liquid chromatography column. Background Technology

[0002] Liquid chromatography (LC) uses a high-pressure pump to propel the mobile phase (such as a solvent or mixed solvent) through a chromatographic column. Components, due to differences in molecular polarity, size, and other properties, exhibit varying forces between the stationary phase (such as packed particles) and the mobile phase, resulting in different elution sequences and achieving separation. It is widely used in pharmaceutical analysis, environmental monitoring, and biochemical research, and is particularly suitable for the separation and detection of thermally unstable or non-volatile substances. During operation, the chromatograph needs to retain impurities in the liquid; therefore, its internal sieve plates are prone to clogging and require cleaning.

[0003] Chinese patent CN219084852U discloses a liquid chromatography column. Even after multiple disassemblies and reassemblies of the sieve plate, the compression spring and push plate can still press the sieve plate to ensure the sealing performance of the device, preventing the column efficiency from decreasing due to a decline in sealing.

[0004] However, the device still has shortcomings: the chromatographic column needs to be disassembled when cleaning the sieve plate, and the disassembly and assembly process is prone to causing the packing material inside the packing tube to leak, and the operation is time-consuming and labor-intensive. Utility Model Content

[0005] The purpose of this invention is to address the problems existing in the background technology by proposing a liquid chromatography column.

[0006] The technical solution of this utility model is: a liquid chromatography column, including a packing tube, with an external threaded tube provided at each end of the packing tube;

[0007] The column cap includes two column caps. The column caps are provided with cylindrical cavities, and the outer walls of the column caps are arranged in a ring array around their axis, with a guide pipe, an air blowing pipe, an internal threaded pipe and a drain pipe communicating with the cylindrical cavity. The internal threaded pipes on the two column caps are respectively spirally connected to the corresponding external threaded pipes on the packing pipe.

[0008] A column is set inside a cylindrical cavity and fits against its inner wall. A through hole is provided on the column along its radial direction. A sieve plate is set inside the through hole near the opening on one side.

[0009] And a drive assembly, which is mounted on the column cap. When in operation, the drive assembly drives the column to rotate, so that the through hole switches from being connected to the feed pipe and the internal threaded pipe to being connected to the air blowing pipe and the sewage discharge pipe.

[0010] Preferably, a cylindrical groove coaxially connected to the through hole is provided in the column body, and a guide cylinder sliding along its height direction is provided in the cylindrical groove. The screen plate is coaxially connected to the guide cylinder. The arc surface of the guide cylinder and the screen plate facing the internal threaded pipe is consistent with the arc surface of the column body, and the outer end face of the guide cylinder abuts against the external threaded pipe.

[0011] Preferably, a limiting strip B is provided on the inner wall of the cylindrical groove along its axial direction, and a guide groove A is provided on the outer wall of the guide cylinder along its height direction, with the guide groove A slidably connected to the limiting strip B.

[0012] Preferably, a limiting ring is provided at the end of the external threaded tube away from the packing tube, which rotates coaxially with it. The end of the limiting ring away from the packing tube is inserted into the cylindrical cavity and slides in contact with the arc surface of the column, the guide cylinder and the screen plate.

[0013] Preferably, a limiting strip A is provided on the side wall of the limiting ring along its height direction, and a guide groove B is provided on the inner wall of the internally threaded tube along its height direction. The limiting strip A is inserted into the guide groove B and slidably connected to it.

[0014] Preferably, the feed pipe is detachably equipped with an end cap A for sealing its channel, the air blowing pipe is detachably equipped with an end cap B for sealing its channel, and the sewage pipe is detachably equipped with an end cap C for sealing its channel.

[0015] Preferably, the drive assembly includes a central column, a slider, a positioning column, a spring rod, and a U-shaped handle. One end of the central column is inserted into the column cap and coaxially connected to the column body. A groove A is provided on the central column along its axial direction, and a groove B communicating with groove A is also provided on the central column. The slider is disposed in the groove A and slides along the axial direction of the central column. A protrusion is provided on the slider, with the end of the protrusion away from the slider extending outward along the groove B. The positioning column is connected to the end of the protrusion near the column cap. Several positioning holes are arranged in a circular array around the axis of the column body on the end face of the column cap. The positioning column is inserted into the positioning hole on the corresponding side and slidably connected to it. The spring rod is disposed in the groove A, with one end connected to the inner wall of the groove A and the other end connected to the end of the slider away from the column body. The U-shaped handle is connected to the protrusion to indicate the orientation of the current through hole.

[0016] Compared with the prior art, the present invention has the following beneficial technical effects:

[0017] By designing a column cap and column body structure, the column cap features a circular array of feed pipes, air blowing pipes, internally threaded pipes, and drain pipes. The column body has through holes into which the sieve plate is placed. Rotating the column body changes the orientation of the through holes. This structure allows the through holes to connect the feed pipes and internally threaded pipes when liquid chromatography is required, and to connect the air blowing pipes and drain pipes when cleaning the filter plate. Furthermore, the device includes positioning holes and positioning columns to restrict the column's free rotation, making filter plate cleaning simple and convenient. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of one embodiment of the present utility model;

[0019] Figure 2 This is a schematic diagram of the structure of the packing tube;

[0020] Figure 3 A schematic diagram of the connection structure of the various components on the column cap;

[0021] Figure 4 This is a schematic diagram of the connection structure of the various components on the column.

[0022] Reference numerals: 1. Packing tube; 2. External threaded tube; 3. Limiting ring; 301. Limiting strip A; 4. Column cap; 401. Cylindrical cavity; 402. Positioning hole; 5. Column; 501. Through hole; 502. Cylindrical groove; 503. Limiting strip B; 51. Center column; 511. Slide groove A; 512. Slide groove B; 6. Guide cylinder; 601. Guide groove A; 7. Screen plate; 8. Guide tube; 81. End cap A; 9. Air blowing pipe; 91. End cap B; 10. Internal threaded tube; 1001. Guide groove B; 11. Drain pipe; 111. End cap C; 12. Slider; 13. Protruding plate; 14. Positioning column; 15. Spring rod; 16. U-shaped handle. Detailed Implementation

[0023] Example 1

[0024] like Figures 1-4As shown, the present invention proposes a liquid chromatography column, including a packing tube 1, a column cap 4, a column body 5, and a drive assembly. The packing tube 1 has an externally threaded tube 2 at each end. The column cap 4 includes two caps, each containing a cylindrical cavity 401. A feed tube 8, a purge tube 9, an internally threaded tube 10, and a drain tube 11, communicating with the cylindrical cavity 401, are arranged in a ring array around the outer wall of the column cap 4. The feed tube 8 has a detachable end cap A81 for sealing its passage; the purge tube 9 has a detachable end cap B91 for sealing its passage; and the drain tube 11 has a detachable end cap C111 for sealing its passage. The pipes and end caps are connected by a single... The connection is not limited to threaded connection. The internal threaded tubes 10 on the two column caps 4 are respectively spirally connected to the corresponding external threaded tubes 2 on the packing tube 1. The column body 5 is set in the cylindrical cavity 401 and fits against its inner wall. A through hole 501 is set on the column body 5 along its radial direction. A screen plate 7 is set in the through hole 501 near the opening on one side. A cylindrical groove 502 is set in the column body 5 and coaxially connected with the through hole 501. A guide cylinder 6 is set in the cylindrical groove 502 and slides along its height direction. The screen plate 7 is coaxially connected with the guide cylinder 6. The arc surface of the guide cylinder 6 and the screen plate 7 facing the internal threaded tube 10 is consistent with the arc surface of the column body 5, and the outer end face of the guide cylinder 6 abuts against the external threaded tube 2. The drive assembly is mounted on the column cap 4. The drive assembly includes a central column 51, a slider 12, a positioning column 14, a spring rod 15, and a U-shaped handle 16. One end of the central column 51 is inserted into the column cap 4 and coaxially connected to the column body 5. A groove A511 is provided on the central column 51 along its axial direction, and a groove B512 communicating with the groove A511 is also provided on the central column 51. The slider 12 is disposed within the groove A511 and slides along the axial direction of the central column 51. A protrusion 13 is provided on the slider 12, and the end of the protrusion 13 away from the slider 12 slides along the groove B51. 2. The positioning post 14 extends outward and is connected to the end of the protruding plate 13 near the post cap 4. Several positioning holes 402 are arranged in a circular array around the axis of the column body 5 on the end face of the post cap 4. The positioning post 14 is inserted into the positioning hole 402 on the corresponding side and slidably connected to it. The spring rod 15 is set in the slide groove A511. One end of the spring rod 15 is connected to the inner wall of the slide groove A511 and the other end is connected to the end of the slider 12 away from the column body 5. The U-shaped handle 16 is connected to the protruding plate 13 to indicate the current orientation of the through hole 501. The drive assembly drives the column body 5 to rotate in the working state, so that the through hole 501 switches from the state of conducting the guide pipe 8 and the internal threaded pipe 10 to the state of conducting the air blowing pipe 9 and the sewage pipe 11.

[0025] In this embodiment, during assembly, the column cap 4 at one end is first rotated off the packing tube 1, then the packing is filled. Next, the column cap 4 is reinstalled on the packing tube 1. The end caps A81 on the guide pipes 8 of both column caps 4 are opened to connect the material pipeline. The material enters the through hole 501 through the guide pipe 8 and passes through the filter holes of the sieve plate 7 into the packing tube 1. After testing, the sieve plate 7 needs to be cleaned. At this time, the U-shaped handle 16 is pulled, causing the slider 12 and the convex plate 13 to slide, thereby pulling the positioning column 14 out of the current positioning hole 402. Then, the U-shaped handle 16 is rotated, causing the column body 5 to rotate 90 degrees through the U-shaped handle and the central column 51. The U-shaped handle 16 is then released, causing the positioning column 14 to lock. Insert the column 5 into the positioning hole 402 at the current position to prevent it from rotating freely. At this time, the inlet end of the through hole 501 is connected to the air blowing pipe 9, while the outlet end of the through hole 501 is connected to the drain pipe 11. Open the end caps B91 and C111, and blow high-pressure air into the through hole 501 along the air blowing pipe 9. Use the airflow to unclog and clean the screen plate 7. The impurities attached to the screen plate 7 and the impurities blocking its filter holes are discharged from the drain pipe 11 under the action of the airflow, thus completing the cleaning operation of the screen plate 7. If it is inconvenient to blow air, place a cloth on the table, make the outlet of the drain pipe 11 face down, and tap it on the upper surface of the cloth to clean the screen plate 7. After cleaning, rotate the column 5 to restore it to its original state.

[0026] Example 2

[0027] like Figures 2-4 As shown, the liquid chromatography column proposed in this utility model, compared with Embodiment 1, has a limiting strip B503 provided on the inner wall of the column groove 502 along its axial direction, and a guide groove A601 provided on the outer wall of the feed tube 6 along its height direction. The guide groove A601 is slidably connected to the limiting strip B503. A limiting ring 3 is provided at the end of the external threaded tube 2 away from the packing tube 1, and rotates coaxially with it. The end of the limiting ring 3 away from the packing tube 1 is inserted into the column cavity 401 and slides in contact with the arc surface of the column body 5, the feed tube 6, and the sieve plate 7. A limiting strip A301 is provided on the side wall of the limiting ring 3 along its height direction, and a guide groove B1001 is provided on the inner wall of the internal threaded tube 10 along its height direction. The limiting strip A301 is inserted into the guide groove B1001 and slidably connected to it.

[0028] In this embodiment, a connection structure is provided between the guide cylinder 6 and the screen plate 7, making it easy to replace the screen plate 7 after long-term use or corrosion. The cooperation structure between the limiting strip B503 and the guide groove A601 makes it easier for the guide cylinder 6 to be inserted into the cylindrical groove 502 and restricts the rotation of the guide cylinder 6 and the screen plate 7. The limiting ring 3 supports the guide cylinder 6 and prevents it from sliding along the axial direction of the packing tube 1. At the same time, the limiting strip A301 on the limiting ring cooperates with the guide groove B1001 on the internal thread tube 10 to limit the rotation of the limiting ring 3 and make it easy to accurately fit the limiting ring 3 with the guide cylinder 6 after it is inserted into the internal thread tube 10.

[0029] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited thereto. Various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention.

Claims

1. A liquid chromatography column, characterized in that, include: A packing tube (1) is provided at both ends of the packing tube (1) with an external threaded tube (2); The column cap (4) includes two columns. A cylindrical cavity (401) is provided inside the column cap (4). A guide pipe (8), an air blowing pipe (9), an internal threaded pipe (10) and a drain pipe (11) communicating with the cylindrical cavity (401) are arranged in a ring array around the axis of the column cap (4). The internal threaded pipes (10) on the two column caps (4) are respectively spirally connected to the external threaded pipes (2) on the corresponding side of the packing pipe (1). A column (5) is set inside a cylindrical cavity (401) and fits against its inner wall. A through hole (501) is provided on the column (5) along its radial direction. A sieve plate (7) is provided inside the through hole (501) near the opening on one side. And a drive assembly, which is set on the column cap (4). When the drive assembly is in working condition, it drives the column (5) to rotate so that the through hole (501) is switched from the state of connecting the feed pipe (8) and the internal thread pipe (10) to the state of connecting the air blowing pipe (9) and the sewage pipe (11).

2. The liquid chromatography column according to claim 1, characterized in that, A cylindrical groove (502) coaxially connected to the through hole (501) is provided inside the column (5). A guide cylinder (6) that slides along its height direction is provided inside the cylindrical groove (502). The screen plate (7) is coaxially connected to the guide cylinder (6). The arc surface of the guide cylinder (6) and the screen plate (7) facing the internal threaded pipe (10) is consistent with the arc surface of the column (5), and the outer end face of the guide cylinder (6) abuts against the external threaded pipe (2).

3. A liquid chromatography column according to claim 1, characterized in that, A limiting strip B (503) is provided on the inner wall of the cylindrical groove (502) along its axial direction, and a guide groove A (601) is provided on the outer wall of the guide cylinder (6) along its height direction. The guide groove A (601) is slidably connected to the limiting strip B (503).

4. A liquid chromatography column according to claim 2, characterized in that, A limiting ring (3) is provided at the end of the external threaded tube (2) away from the packing tube (1) and rotates coaxially with it. The end of the limiting ring (3) away from the packing tube (1) is inserted into the cylindrical cavity (401) and slides in contact with the arc surface of the column (5), the guide cylinder (6) and the sieve plate (7).

5. A liquid chromatography column according to claim 4, characterized in that, A limiting strip A (301) is provided on the side wall of the limiting ring (3) along its height direction, and a guide groove B (1001) is provided on the inner wall of the internal threaded pipe (10) along its height direction. The limiting strip A (301) is inserted into the guide groove B (1001) and slidably connected to it.

6. A liquid chromatography column according to claim 1, characterized in that, The feed pipe (8) is detachably fitted with an end cap A (81) for closing its channel, the air blowing pipe (9) is detachably fitted with an end cap B (91) for closing its channel, and the sewage pipe (11) is detachably fitted with an end cap C (111) for closing its channel.

7. A liquid chromatography column according to claim 1, characterized in that, The drive assembly includes a central column (51), a slider (12), a positioning column (14), a spring rod (15), and a U-shaped handle (16). One end of the central column (51) is inserted into the column cap (4) and coaxially connected to the column body (5). A groove A (511) is provided on the central column (51) along its axial direction, and a groove B (512) communicating with the groove A (511) is provided on the central column (51). The slider (12) is located in the groove A (511) and slides along the axial direction of the central column (51). A protrusion (13) is provided on the slider (12), and the end of the protrusion (13) away from the slider (12) extends outward along the groove B (512). The positioning post (14) extends and is connected to the end of the protruding plate (13) near the post cap (4). Several positioning holes (402) are arranged in a ring array around the axis of the column (5) on the end face of the post cap (4). The positioning post (14) is inserted into the positioning hole (402) on the corresponding side and is slidably connected to it. The spring rod (15) is set in the slide groove A (511). One end of the spring rod (15) is connected to the inner wall of the slide groove A (511) and the other end is connected to the end of the slider (12) away from the column (5). The U-shaped handle (16) is connected to the protruding plate (13) to indicate the orientation of the current through hole (501) through the U-shaped handle (16).

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