Ion transport device
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- 至秦仪器(合肥)有限公司
- Filing Date
- 2025-05-30
- Publication Date
- 2026-06-26
Smart Images
Figure CN224417751U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of mass spectrometry analysis technology, and in particular to an ion transport device. Background Technology
[0002] Traditional ESI electrospray emitters face the mass spectrometer inlet. Due to the dispersion of the ESI electrospray plume and the rapid expansion of the radial plume, the proportion of ions that successfully enter the mass spectrometer is very small. Data shows that the ion transport efficiency of this process is far less than 1%.
[0003] In addition, due to the accumulation of a large number of charged droplets on the surface of the mass spectrometer inlet, particles of the same polarity will repel each other, which will also reduce the number of ions entering the mass spectrometer.
[0004] Similar to the ESI electrospraying mentioned above, the same phenomenon also occurs in mass spectrometry using EI and APCI sources. Electrons emitted by the EI source filament enter the ionization chamber and are dispersed due to the repulsive force of the magnet, resulting in lower ionization efficiency for the sample after entering the ionization chamber.
[0005] APCI source converts the sample into gaseous sample molecules. The gaseous sample becomes charged after passing through the corona discharge needle and is carried into the mass spectrometer by the auxiliary gas and the negative pressure at the mass spectrometer inlet. However, the number of sample ions entering the mass spectrometer is often reduced due to factors such as the auxiliary gas flow rate.
[0006] Therefore, how to design an ion transport device that can improve ion transport efficiency is a technical problem that the industry urgently needs to solve. Utility Model Content
[0007] In view of the problems of low ion proportion and low ion transmission efficiency in existing technologies, this invention proposes an ion transmission device.
[0008] The technical solution of this utility model is to propose an ion transmission device, 1. including an ion source, the ion source being arranged toward the mass spectrometry inlet of a mass spectrometer, characterized in that it further includes a dielectric ring disposed at the mass spectrometry inlet of the mass spectrometer.
[0009] Furthermore, the ion source is ESI electrospray;
[0010] The ESI electrospray is 3mm to 7mm away from the mass spectrometer inlet, the ESI electrospray is at a 45-degree angle to the horizontal direction, and the outlet is set towards the mass spectrometer inlet.
[0011] Furthermore, the dielectric ring is located 0.1 mm to 0.3 mm in front of the mass spectrometer inlet.
[0012] Furthermore, the aperture of the dielectric ring is between 0.5 mm and 2 mm, and the ring width of the dielectric ring is 0.3 mm.
[0013] Furthermore, the dielectric constant of the dielectric ring is between 5.7 and 6.3.
[0014] Furthermore, the ionization voltage of the ESI electrospray is between 2000V and 3500V.
[0015] Furthermore, the ion source is an EI source, which has a filament for generating electrons, an ionization chamber for transmitting sample ions and electrons, and a focusing lens for focusing ions.
[0016] The ion transport device includes a first dielectric ring disposed in front of the focusing lens and a second dielectric ring disposed at the inlet of the filament to the ionization chamber.
[0017] Furthermore, the thickness of the first dielectric ring is 0.3 mm to 0.5 mm, the ring width of the first dielectric ring is 0.2 mm, the diameter of the first dielectric ring is 0.2 mm larger than the diameter of the ionization chamber inlet, and the dielectric constant of the first dielectric ring is 5.7 to 6.3.
[0018] Furthermore, the thickness of the second dielectric ring is 0.1 mm, the width of the second dielectric ring is 0.3 mm, and the distance between the second dielectric ring and the first lens in the focusing lens is 0.2 mm.
[0019] Furthermore, the ion source is an APCI source, the dielectric ring has an aperture of 0.7 mm, a thickness of 0.3 mm, and is located 0.1 mm before the mass spectrometer inlet.
[0020] Compared with the prior art, the present invention has at least the following beneficial effects:
[0021] This invention utilizes the polarization effect of a dielectric ring in an electric field to generate polarization charges on the surface of the dielectric ring, forming a polarized electric field for focusing and transporting charged particles. Attached Figure Description
[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0023] Figure 1This is a schematic diagram of the ESI electrospray structure with added dielectric ring in this utility model;
[0024] Figure 2 This is a schematic diagram of the EI source with added dielectric ring in this utility model;
[0025] Figure 3 This is a schematic diagram of the APCI source with added dielectric ring in this utility model;
[0026] Figure 4 This is a simulation diagram of the ESI electrospray ion trajectory without dielectric ring in this invention;
[0027] Figure 5 This is a simulation diagram of the ESI electrospray ion trajectory of the present invention, which contains a dielectric ring. Detailed Implementation
[0028] To make the technical problems, technical solutions, and beneficial effects of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.
[0029] Therefore, a feature pointed out in this specification is used to describe one feature of one embodiment of the present invention, and does not imply that every embodiment of the present invention must have the described feature. Furthermore, it should be noted that this specification describes many features. Although certain features may be combined to illustrate possible system designs, these features may also be used in other combinations not explicitly stated. Therefore, unless otherwise stated, the described combinations are not intended to be limiting.
[0030] The principle and structure of this utility model will be described in detail below with reference to the accompanying drawings and embodiments.
[0031] Currently, the commonly used ion sources for mass spectrometers are ESI electrospray, EI source, and APCI source. However, for ESI electrospray, due to the dispersion of the plume and the rapid expansion of the radial plume, the proportion of ions that successfully enter the mass spectrometer is very small.
[0032] For EI sources, the filament electrons will be dispersed when they enter the ionization chamber, which will lead to a lower sample ionization efficiency.
[0033] For APCI sources, the number of sample ions entering the mass spectrometer decreases due to factors such as the auxiliary gas velocity.
[0034] Based on the above problems, the design concept of this utility model is to utilize the polarization effect of the dielectric ring in an electric field to generate polarization charges on the surface of the dielectric ring, forming a polarized electric field to focus and transport charged particles, thereby improving ion transport efficiency.
[0035] Based on the above design concept, this utility model proposes an ion transmission device, which includes an ion source that is positioned toward the mass spectrometry inlet of a mass spectrometer.
[0036] The ion transport device also includes a dielectric ring disposed at the mass spectrometer inlet.
[0037] In this setting, the dielectric ring can be used to focus and transport charged particles, thereby increasing the number of charged particles entering the mass spectrometer and improving ion transport efficiency.
[0038] For cases where the ion source is ESI electrospray, the present invention sets the distance between the ESI electrospray and the mass spectrometer inlet to be 3mm to 7mm, the ESI electrospray is at a 45-degree angle to the horizontal direction, and the outlet is set towards the mass spectrometer inlet.
[0039] The dielectric ring is positioned 0.1 mm to 0.3 mm in front of the mass spectrometer inlet.
[0040] Please see Figure 1 This is a schematic diagram of the structure when a dielectric ring is set in the aforementioned ESI electrospray ionization. The ESI electrospray ionizes the liquid sample into charged particles, and the dielectric ring focuses the diverging charged particles at the mass spectrometer inlet. In this configuration, due to the accumulation of the polarization electric field and charged particles on the dielectric plate, a focusing ring with an electric field is formed on the dielectric ring. This allows a large number of charged particles generated by electrospray to be focused at the mass spectrometer inlet, thereby improving ion transport efficiency.
[0041] In this configuration, to facilitate the focusing of charged particles, in a preferred embodiment of this invention, the aperture of the dielectric ring is set to be between 0.5 mm and 2 mm, and the ring width of the dielectric ring is 0.3 mm. Here, the ring width of the dielectric ring is the difference between the inner diameter and the outer diameter of the dielectric ring.
[0042] Preferably, in one embodiment of the present invention, the dielectric constant of the dielectric ring is between 5.7 and 6.3.
[0043] Similarly, in order to better ionize ESI electrospray and obtain charged particles, in a preferred embodiment of this invention, the ionization voltage of ESI electrospray is set between 2000V and 3500V.
[0044] For cases where the ion source is an ES source, the EI source in this invention has a filament for generating electrons, an ionization chamber for transmitting sample ions and electrons, and a focusing lens for focusing ions.
[0045] The ion transport device includes a first dielectric ring disposed in front of the focusing lens and a second dielectric ring disposed at the inlet from the filament to the ionization chamber.
[0046] Please see Figure 2 This is a schematic diagram of the structure of the EI source with a dielectric ring, where N and S are magnets used to accelerate electrons and increase the probability of interaction between electrons and gaseous sample molecules, thereby improving ionization efficiency. Alternatively, high and low potential fields can be used to accelerate electrons and increase the probability of interaction between electrons and gaseous sample molecules to improve the sample ionization rate.
[0047] The filament is used to generate electrons;
[0048] The first dielectric ring is used to focus the filament electrons entering the ionization chamber;
[0049] In this invention, to achieve the above objectives, the thickness of the first dielectric ring is set to 0.3 mm to 0.5 mm, the ring width of the first dielectric ring is set to 0.2 mm, the diameter of the first dielectric ring is set to be 0.2 mm larger than the diameter of the ionization chamber inlet, and the dielectric constant of the first dielectric ring is set to 5.7 to 6.3.
[0050] The receiving electrode is used for the efficient extraction, focusing, and acceleration of electrons;
[0051] The repulsion electrode is used to ionize sample molecules, which are then focused by the focusing lens and finally transmitted to the mass spectrometer for analysis.
[0052] The second dielectric ring is used to remove electrons and focus sample ions;
[0053] In this invention, to achieve the above objectives, the thickness of the second dielectric ring is set to 0.1 mm, the ring width of the second dielectric ring is set to 0.3 mm, and the distance between the second dielectric ring and the first lens in the focusing lens is set to 0.2 mm.
[0054] For cases where the ion source is an APCI source, the dielectric ring in this invention has an aperture of 0.7 mm, a thickness of 0.3 mm, and is located 0.1 mm in front of the mass spectrometer inlet.
[0055] Please see Figure 3 The diagram shows the structure of the APCI source with a dielectric ring. The working process is as follows: the sample solution flows into the injection tube, vaporizes under external heating, is carried out by the auxiliary gas, and enters the mass spectrometer with a charge after passing through the electric field around the discharge needle. The dielectric ring is used to focus the charged sample ions so that they can enter the mass spectrometer.
[0056] In this setting, for the original APCI source, without a dielectric ring, the mass spectrometer only relies on negative pressure to bring in ions, resulting in a small amount of ions entering. After setting the dielectric ring, the dielectric ring can effectively focus the ions into the mass spectrometer inlet through the electric field it generates.
[0057] Please see Figure 4 and Figure 5 As can be seen from the above settings, this invention can effectively focus ions and allow them to enter the mass spectrometer by setting up a dielectric ring, thereby improving ion transmission efficiency.
[0058] In other embodiments of this utility model, five dielectric plates with a dielectric constant of 5.7, each 0.2 mm thick, and apertures of 0.5 mm, 0.7 mm, 1.0 mm, 1.2 mm, and 1.4 mm respectively can be stacked coaxially and placed into an annular dielectric funnel with a gap of 0.2 mm. The ESI electrospray emitter is 3 mm away from the dielectric plate with the largest aperture and 5.1 mm away from the mass spectrometer inlet. Compared with the case without dielectric plates, the signal is improved to a certain extent.
[0059] Based on the above-mentioned dielectric ring configuration, this invention has at least the following advantages compared with the prior art:
[0060] This invention utilizes the polarization effect of a dielectric ring in an electric field to generate polarization charges on the surface of the dielectric ring, forming a polarized electric field for focusing and transporting charged particles.
[0061] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. An ion transport device, comprising an ion source disposed toward the mass spectrometry inlet of a mass spectrometer, characterized in that, It also includes a dielectric ring disposed at the mass spectrometer inlet of the mass spectrometer.
2. The ion transport device according to claim 1, characterized in that, The ion source is an ESI electrospray ionization source; The ESI electrospray is 3mm to 7mm away from the mass spectrometer inlet, the ESI electrospray is at a 45-degree angle to the horizontal direction, and the outlet is set towards the mass spectrometer inlet.
3. The ion transport device according to claim 2, characterized in that, The dielectric ring is located 0.1 mm to 0.3 mm in front of the mass spectrometer inlet.
4. The ion transport device according to claim 2, characterized in that, The aperture of the dielectric ring is between 0.5 mm and 2 mm, and the ring width is 0.3 mm.
5. The ion transport device according to claim 2, characterized in that, The dielectric constant of the dielectric ring is between 5.7 and 6.
3.
6. The ion transport device according to claim 2, characterized in that, The ionization voltage of the ESI electrospray is between 2000V and 3500V.
7. The ion transport device according to claim 1, characterized in that, The ion source is an EI source, which has a filament for generating electrons, an ionization chamber for transmitting sample ions and electrons, and a focusing lens for focusing ions. The ion transport device includes a first dielectric ring disposed in front of the focusing lens and a second dielectric ring disposed at the inlet of the filament to the ionization chamber.
8. The ion transport device according to claim 7, characterized in that, The thickness of the first dielectric ring is 0.3 mm to 0.5 mm, the ring width of the first dielectric ring is 0.2 mm, the diameter of the first dielectric ring is 0.2 mm larger than the diameter of the ionization chamber inlet, and the dielectric constant of the first dielectric ring is 5.7 to 6.
3.
9. The ion transport device according to claim 7, characterized in that, The second dielectric ring has a thickness of 0.1 mm, a ring width of 0.3 mm, and a distance of 0.2 mm from the second dielectric ring to the first lens in the focusing lens.
10. The ion transport device according to claim 1, characterized in that, The ion source is an APCI source, the dielectric ring has an aperture of 0.7 mm, a thickness of 0.3 mm, and is located 0.1 mm in front of the mass spectrometer inlet.