An apparatus for configuring a supramolecular bioextract gel formulation

Abstract

The utility model discloses a kind of supramolecular biological extract gel preparation configuration devices, it relates to biological extraction technical field, the supramolecular biological extract gel preparation configuration device, including inner container, heating jacket and heat preservation layer that are successively sleeved from inside to outside, drive motor is equipped on heat preservation layer upper end, its rotating shaft is through inner container and is connected anchor type paddle, propeller and turbine paddle, heat preservation layer is equipped with multiple sensor components with PT100 temperature probe on, rear end is inserted with automatic cleaning shower nozzle's PH electrode module through flange pipe, left lower end is equipped with adding pump, upper end is equipped with outlet valve, medium inlet pipe and electric three-way valve, right end is equipped with control unit module through L type support. Through three-layer paddle layered stirring, global temperature monitoring, real-time pH adjustment and PID closed-loop control, accurately maintain reaction temperature 37±3 ℃, pH7.2±0.4, guarantee supramolecular aggregate (molecular weight 438kDa-1000kDa) stable formation, improve gel preparation function effect, suitable for supramolecular gel preparation of biological active ingredient.

Description

Technical Field

[0001] This utility model relates to the field of bio-extraction technology, and in particular to a device for preparing supramolecular biological extract gel formulations. Background Technology

[0002] Supramolecular polymers are polymer systems formed based on non-covalent interactions and self-assembly. Supramolecular polymer gels are a very important type of soft matter material, representing a novel concept and a more complex gel system. The construction of this new supramolecular system is based on the multi-level assembly of multiple non-covalent interactions. That is, small molecule building blocks first assemble into supramolecular polymers, and the multi-level assembly of these non-covalent polymers forms the nanostructure of the gel.

[0003] Supramolecular polymers are typically constructed through bifunctional molecular systems of AA and BB. They form supramolecular polymers through non-covalent interactions between A and B, such as hydrogen bonding, coordination, and the synergistic effect of various non-covalent interactions. Multiple hydrogen bonds, host-guest interactions, and coordination interactions of polar molecules readily enable supramolecular polymers to form gel structures.

[0004] Researchers have now been able to control the molecular weight of supramolecular polymers by manipulating the degree of polymerization. Supramolecular polymer gel systems exhibit excellent dual-response properties, primarily because the sol-gel transition can be induced by both temperature and pH changes. Utilizing these properties, introducing covalent polymers into supramolecular polymer gel systems based on host-guest interactions can enhance their mechanical properties.

[0005] Our company uses sea fennel extract, type III collagen, and niacinamide as the main functional ingredients to prepare supramolecular polymer gels. These gels form molecular aggregates with molecular weights ranging from 438kDa to 1000kDa, based on non-covalent intermolecular interactions. The molecules are bound together by intermolecular interactions, forming complex, organized aggregates that maintain a defined microstructure and macroscopic properties. The supramolecular gel exhibits greater stability, and the macroscopic intermolecular interactions within the supramolecular gel aggregates enhance the functional effects of each component, thereby improving the firming, anti-aging, and repairing functions of the polymer gel.

[0006] Sea fennel extract (mainly limonene, γ-terpinene, and thymol methyl ether, with a molecular weight below 400 Da) has the following main effects: ① thickens the epidermis while making the dermis firmer; ② accelerates the recovery of damaged skin and reduces redness; ③ brightens skin tone and dullness in multiple dimensions; ④ has other functions such as anti-oxidation and accelerating the metabolism of dead skin cells. Type III collagen (recombinant humanized type III collagen, molecular weight 438 kDa) is the main collagen in human skin, fascia, and tendons, with a ratio of 4:1 to type I collagen. The cushion network, primarily composed of type III collagen, refers to the tissue structure located between the epidermis and dermis. It is crucial for supporting the epidermis and is the first step in skin sagging. The cushion network can be observed using CLSM laser scanning confocal microscopy and OCT optical coherence tomography, as it is invisible with conventional microscopes or techniques. Type III collagen is relatively small and exists between the epidermis and dermis; it is sometimes referred to as "infant collagen."

[0007] Nicotinamide, also known as nicotinamide (molecular weight 122 Da), is an amide compound of nicotinic acid. It is a white crystalline powder; odorless or almost odorless, with a bitter taste; slightly hygroscopic. It is readily soluble in water or ethanol and soluble in glycerin. Nicotinamide can prevent rough skin, maintain healthy skin cells, and promote skin whitening. In hair care, it can promote scalp blood circulation, healthy hair follicles, promote hair growth, and prevent baldness.

[0008] In the preparation of supramolecular polymer gels using sea fennel extract, type III collagen, and niacinamide as the main functional ingredients, a dissipative network formation process induced by percolation to separate the gel phases was achieved in a diluted polymer-water mixture. During the deswelling process after gelation, at the percolation threshold, the single-phase diluted system spontaneously separated into two co-continuous gel phases (diluted-percolated gel) with sub-millimeter scale. The diluted percolated gel containing 99% water exhibited excellent hydrophobicity. Building upon the original firming, anti-aging, repairing, and wrinkle-reducing effects of the functional ingredients, it induced the development of adipose-like tissue in the subcutaneous tissue, promoting plump and full skin.

[0009] However, the following problems still exist in the preparation of supramolecular polymer gels using sea fennel extract, type III collagen, and niacinamide as the main functional ingredients: The sol-gel transition of a system can be achieved by altering both temperature and pH. In the preparation of supramolecular polymer gels from active ingredients such as sea fennel, nicotinamide, and recombinant human type III collagen, temperature control (37°C ± 3°C) and pH control (7.2 ± 0.4) are employed. Temperature affects the efficiency and stability of intermolecular interactions in supramolecular gels, while pH affects the non-covalent bonding of molecules, thus influencing the functional performance of each gel component. Therefore, it is crucial to control temperature, electrostatic charge, and pH. Although some purification and preparation reaction apparatuses have heating components, it is impossible to directly monitor the temperature and pH at various points within the reaction vessel, making it difficult to prepare supramolecular gels with superior performance compared to conventional gels.

[0010] Traditional gel formulation production equipment has the following drawbacks: temperature control relies on external detection, has a delayed response, and affects the activity of heat-sensitive components; pH values ​​require offline sampling and testing, making it impossible to adjust acidity and alkalinity in real time; key parameters and mixing processes are not under closed-loop control, resulting in large batch variations.

[0011] Therefore, it is necessary to propose a device for preparing a bio-extract firming, anti-aging, and repairing supramolecular gel formulation to solve the above problems. Utility Model Content

[0012] The purpose of this invention is to at least solve one of the technical problems existing in the prior art, and to provide a supramolecular biological extract gel preparation device that can solve the problem of preparing a biological extract firming, anti-aging and repair supramolecular gel preparation.

[0013] To achieve the above objectives, the present invention provides the following technical solution: a supramolecular biological extract gel preparation device, comprising an inner liner, a heating jacket, and a heat insulation layer, characterized in that: a flange is fixedly connected to the upper end of the heat insulation layer, a drive motor is fixedly connected to the flange by screws, a support module is fixedly connected to the lower part of the heat insulation layer, the support module consists of four support rods, and an anti-slip pad is fixedly connected to the lower part of each support rod; The output end of the drive motor is fixedly connected to a rotating shaft, which is installed through the inner liner. An anchor propeller, a propeller and a turbine propeller are fixedly connected to the rotating shaft from top to bottom. Multiple sensor assemblies are fixedly installed on the insulation layer. Each sensor assembly is fixedly connected to a PT100 temperature probe. The end of the PT100 temperature probe is located inside the inner liner, and a polytetrafluoroethylene sealing ring is provided at the contact point with the inner wall of the inner liner. The rear end of the insulation layer is fixedly connected to a flange tube, and a pH electrode module is inserted into the flange tube. The end of the pH electrode module located inside the inner liner is equipped with an automatic cleaning nozzle. The front end of the flange tube is fixedly connected to a circular sealing cover by bolts, and the pH electrode module is also inserted into the circular sealing cover. A feeding pump is fixedly connected to the lower left end of the insulation layer. A medium outlet valve is provided between the feeding pump and the support module. The medium outlet valve is fixedly connected to the heating jacket.

[0014] Preferably, the upper end of the insulation layer is provided with an air outlet valve, a medium inlet pipe and an electric three-way valve, the medium inlet pipe is fixedly connected to the heating jacket, and the electric three-way valve is fixedly installed on the medium inlet pipe; an L-shaped bracket is fixedly connected to the right end of the insulation layer, and a control unit module is fixedly installed on the L-shaped bracket.

[0015] Preferably, the anchor paddle is located at 2 / 3 of the height of the inner liner, in the shape of an "Ω", and the gap between its edge and the side wall of the inner liner is 1-2 cm. The propeller is located at 1 / 2 of the height of the inner liner, and the turbine is located at 1 / 4 of the height of the inner liner.

[0016] Preferably, the sensor assembly is provided in three parts, one of which is fixedly connected to the lower end of the insulation layer, corresponding to the position of the turbine propeller; The other two sensor assemblies are fixedly installed on the outer wall of the insulation layer, corresponding to the positions of the anchor propeller and the propeller, respectively.

[0017] Preferably, the automatic cleaning nozzle is at a 45° angle to the axis of the pH electrode module and is connected to a food-grade silicone tube.

[0018] Preferably, the pump has a bidirectional pump body structure, which is connected to the upper part of the inner tank through a pipeline, and the end of the pipeline is located next to the feed inlet, extending 3-5 cm below the liquid surface.

[0019] Preferably, the control unit module is electrically connected to the drive motor, PT100 temperature probe, pH electrode module, additive pump and electric three-way valve respectively, and has a built-in PID algorithm control module.

[0020] Preferably, both the air outlet valve and the medium outlet valve are one-way valves, the end of the air outlet valve is located inside the inner liner, and the pressure resistance of the medium outlet valve is not less than 0.6 MPa.

[0021] Compared with the prior art, the beneficial effects of this utility model are: (1) The supramolecular biological extract gel preparation device has an upper anchor paddle (located at 2 / 3 of the height of the inner liner) rotating close to the inner wall with Ω-shaped blades. This scrapes off the material attached to the side wall to avoid excessive local concentration and promotes the exchange between the liquid surface and the gas phase to balance dissolved oxygen. The middle propeller (in the middle of the inner liner) generates radial thrust through spiral blades to quickly mix acid / alkali solutions and raw materials, ensuring uniform pH adjustment while strengthening molecular collisions and promoting the initial assembly of supramolecular polymers. The lower turbine paddle (at the bottom of the inner liner) generates downward thrust with a disc turbine structure to stir the deposited type III collagen and other macromolecular components, preventing them from agglomerating and precipitating, ensuring that all raw materials react fully, and finally forming a uniform supramolecular aggregate with a molecular weight of 438kDa-1000kDa.

[0022] (2) In this supramolecular biological extract gel preparation device, the pH electrode module is inserted into the inner liner (located in the mixing uniform area between the propeller and the anchor propeller) through the flange tube. The detection end directly contacts the material and transmits the pH signal to the control unit module 4. The circular sealing cover 15 and the polytetrafluoroethylene sealing ring 24 cooperate to achieve a seal to prevent leakage. When pH < 6.8, the addition pump at the lower left end of the insulation layer starts and injects alkaline solution. The alkaline solution diffuses rapidly under the radial thrust of the propeller to avoid local over-alkalinity. When pH > 7.6, the addition pump switches to injecting acid solution to adjust the pH. When the pH is in the sensitive range of 6.8-7.6, the control unit module reduces the speed of the drive motor to 100-150 rpm to reduce the generation of bubbles and protect the non-covalent bonds between molecules (such as hydrogen bonds and coordination bonds). After each pH adjustment, the automatic cleaning nozzle at the end of the pH electrode module (at 45° with the electrode axis) starts and rinses the residual material on the electrode surface with high-pressure pure water (0.3MPa). The cleaning waste liquid participates in the reaction with the material circulation.

[0023] (3) The supramolecular biological extract gel preparation device has three PT100 temperature probes forming a full-area monitoring network to monitor the temperature of the sedimentation zone at the bottom of the inner liner (near the turbine propeller), the mixing zone at the top (anchor propeller height), and the core reaction zone at the middle (propeller height). The signal is transmitted to the control unit module through a polytetrafluoroethylene sealing ring. According to the monitoring data, the system dynamically adjusts the temperature: when the temperature is below 34℃, the electric three-way valve opens the heating medium passage, and the medium enters the heating jacket through the medium inlet pipe. The temperature of the inner liner is increased through heat conduction, and the insulation layer reduces heat loss. When the temperature is above 40℃, the electric three-way valve switches to the cooling passage, and the medium outlet valve (one-way valve) opens to discharge the high-temperature medium, thereby achieving rapid cooling and ensuring that the temperature of the inner liner is stable at 37±3℃. Attached Figure Description

[0024] The present invention will be further described below with reference to the accompanying drawings and embodiments: Figure 1 This is a schematic diagram of a supramolecular biological extract gel formulation preparation device according to the present invention; Figure 2 This is a rear view schematic diagram of a supramolecular biological extract gel formulation preparation device according to the present invention; Figure 3 This is a schematic cross-sectional view of the internal structure of a supramolecular biological extract gel formulation preparation device according to the present invention. Figure 4 This utility model Figure 3 Enlarged view of point A in the middle; Figure 5 This utility model Figure 3 Enlarged diagram of point B in the middle.

[0025] Reference numerals: 1. Support module; 2. Anti-slip pad; 3. L-shaped support; 4. Control unit module; 5. Medium outlet valve; 6. Addition pump; 7. Insulation layer; 8. Medium inlet pipe; 9. Electric three-way valve; 10. Flange; 11. Drive motor; 12. Air outlet valve; 13. Sensor assembly; 14. Flange pipe; 15. Circular sealing cover; 16. pH electrode module; 17. Heating jacket; 18. Inner liner; 19. Anchor propeller; 20. Propeller; 21. Turbine propeller; 22. Automatic cleaning nozzle; 23. PT100 temperature probe; 24. PTFE sealing ring. Detailed Implementation

[0026] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0027] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0028] In the description of this utility model, terms such as greater than, less than, and exceeding are understood to exclude the stated number, while terms such as above, below, and within are understood to include the stated number. The use of terms like "first" and "second" is merely for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the quantity or sequence of the indicated technical features.

[0029] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.

[0030] Please see Figure 1-5This utility model provides a technical solution: a supramolecular biological extract gel preparation device, including a heating jacket 17 sleeved inside a heat insulation layer 7, an inner liner 18 sleeved inside the heating jacket 17, the heat insulation layer 7, the heating jacket 17, and the inner liner 18 being sequentially sleeved from the inside out, a flange 10 fixedly connected to the upper end of the heat insulation layer 7, a drive motor 11 fixedly connected to the flange 10 by screws, the heat insulation layer 7 being fixedly connected to the drive motor 11 on the flange 10, a support module 1 fixedly connected below the heat insulation layer 7, and the heat insulation layer 7 fixedly connected above the support module 1, the support module 1 consisting of four support rods, each support rod having an anti-slip pad 2 fixedly connected below it. A rotating shaft is fixedly connected to the output end of the drive motor 11. The rotating shaft is installed inside the inner liner 18. An anchor paddle 19 is fixedly connected to the upper end of the rotating shaft. A propeller 20 is fixedly connected to the middle of the rotating shaft. A turbine paddle 21 is fixedly connected to the lower end of the rotating shaft. The upper anchor paddle 19 (located at 2 / 3 of the height of the inner liner 18) rotates close to the inner wall with Ω-shaped blades. It scrapes off the material attached to the side wall to avoid excessive local concentration and promotes the exchange between the liquid surface and the gas phase to balance dissolved oxygen. The middle propeller 20 (in the middle of the inner liner 18) generates radial thrust through spiral blades to quickly mix acid / alkali solutions and raw materials. It ensures the uniformity of pH adjustment while strengthening molecular collisions and promoting the initial assembly of supramolecular polymers. The lower turbine paddle 21 (at the bottom of the inner liner 18) generates downward thrust with a disc turbine structure. It stirs up the deposited type III collagen and other macromolecular components to prevent them from agglomerating and precipitating, ensuring that all raw materials react fully and finally form a uniform supramolecular aggregate with a molecular weight of 438kDa-1000kDa. A sensor assembly 13 is fixedly connected to the lower end of the insulation layer 7. A PT100 temperature probe 23 is fixedly connected to the sensor assembly 13. The end of the PT100 temperature probe 23 is located inside the inner liner 18. A polytetrafluoroethylene sealing ring 24 is fixedly connected to the contact point between the PT100 temperature probe 23 and the inner wall of the inner liner 18. Similarly, two sensor assemblies 13 are fixedly installed on the outer wall of the insulation layer 7. Each sensor assembly 13 is fixedly connected to a PT100 temperature probe 23 and a polytetrafluoroethylene sealing ring 24. The two PT100 temperature probes 23 on the outer wall correspond one-to-one with the anchor propeller 19 and the propeller 20, respectively. A flange pipe 14 is fixedly connected to the rear end of the insulation layer 7. A pH electrode module 16 is inserted into the flange pipe 14. An automatic cleaning nozzle 22 is fixedly connected to the end of the pH electrode module 16 located inside the inner liner 18, and the nozzle of the automatic cleaning nozzle 22 is at a 45° angle to the axis of the pH electrode module 16. A circular sealing cover 15 is fixedly connected to the front end of the flange pipe 14 by bolts. The pH electrode module 16 is also inserted into the circular sealing cover 15. The pH electrode module 16 is inserted into the inner liner 18 (located in the mixing and homogenization area between the propeller 20 and the anchor propeller 19) through the flange pipe 14. The detection end directly contacts the material and transmits the pH signal to the control unit module 4. The circular sealing cover 15 cooperates with the polytetrafluoroethylene sealing ring 24 to achieve a seal and prevent leakage. When pH < 6.8, the addition pump 6 at the lower left end of the insulation layer 7 starts and injects alkaline solution. The alkaline solution diffuses rapidly under the radial thrust of the propeller 20 to avoid local over-alkalinity. When pH > 7.6, the addition pump 6 switches to injecting acid solution to adjust the pH. When the pH is in the sensitive range of 6.8-7.6, the control unit module 4 reduces the speed of the drive motor 11 to 100-150 rpm to reduce bubble generation and protect intermolecular non-covalent bonds (such as hydrogen bonds and coordination bonds). After each pH adjustment, the automatic cleaning nozzle 22 (at 45° to the electrode axis) at the end of the pH electrode module 16 starts and rinses the residual material on the electrode surface with high-pressure pure water (0.3MPa). The cleaning waste liquid participates in the reaction along with the material circulation. A feeding pump 6 is fixedly connected to the lower left end of the insulation layer 7, and the feeding pump 6 is located above the support module 1. A medium outlet valve 5 is provided between the feeding pump 6 and the support module 1. The medium outlet valve 5 is a one-way valve and is fixedly connected to the heating jacket 17. Three PT100 temperature probes 23 form a full-area monitoring network to monitor the temperature of the sedimentation zone at the bottom (near the turbine propeller 21) of the inner liner 18, the mixing zone at the top (height of the anchor propeller 19), and the core reaction zone at the middle (height of the propeller 20). The signal is transmitted through polytetrafluoroethylene (PTFE). The ethylene sealing ring 24 seals the transmission to the control unit module 4. Based on the monitoring data, the system dynamically adjusts the temperature: when the temperature is below 34℃, the electric three-way valve 9 opens the heating medium passage, and the medium enters the heating jacket 17 through the medium inlet pipe 8. The temperature of the inner liner 18 is increased through heat conduction, and the insulation layer 7 reduces heat loss. When the temperature is above 40℃, the electric three-way valve 9 switches to the cooling passage, and the medium outlet valve 5 (one-way valve) opens to discharge the high-temperature medium, achieving rapid cooling and ensuring that the temperature of the inner liner 18 is stable at 37±3℃. From right to left, the upper end of the insulation layer 7 is provided with an air outlet valve 12, a medium inlet pipe 8, and an electric three-way valve 9. The air outlet valve 12 is fixedly connected to the insulation layer 7 and is a one-way valve with its end located inside the inner liner 18. The medium inlet pipe 8 is fixedly connected to the heating jacket 17, and the electric three-way valve 9 is fixedly installed on the medium inlet pipe 8. An L-shaped bracket 3 is fixedly connected to the right end of the insulation layer 7, and a control unit module 4 is fixedly installed on the L-shaped bracket 3.

[0031] Working principle: Sea fennel extract, type III collagen, nicotinamide and other raw materials are put into the inner liner 18 through the feed port (side channel of flange 10) at the upper end of the insulation layer 7. At this time, the air vent valve 12 (one-way valve) is opened to release the air in the inner liner 18 to avoid bubbles interfering with the formation of non-covalent bonds between molecules. Then, the reaction parameters are preset by the control unit module 4 on the L-shaped bracket: target temperature 37±3℃, target pH 7.2±0.4, initial stirring speed 300rpm, and the system enters the standby state. Three PT100 temperature probes 23 form a comprehensive monitoring network, respectively monitoring the temperature of the sedimentation zone at the bottom (near the turbine propeller 21), the mixing zone at the top (height of the anchor propeller 19), and the core reaction zone in the middle (height of the propeller 20) of the inner liner 18. The signals are transmitted to the control unit module 4 through a polytetrafluoroethylene sealing ring 24. Based on the monitoring data, the system dynamically adjusts the temperature: when the temperature is below 34℃, the electric three-way valve 9 opens the heating medium passage, and the medium enters the heating jacket 17 through the medium inlet pipe 8, raising the temperature of the inner liner 18 through heat conduction. The insulation layer 7 reduces heat loss. When the temperature is above 40℃, the electric three-way valve 9 switches to the cooling passage, and the medium outlet valve 5 (one-way valve) opens to discharge the high-temperature medium, achieving rapid cooling and ensuring that the temperature of the inner liner 18 is stable at 37±3℃. The pH electrode module 16 is inserted into the inner tank 18 (located in the mixing and homogenization zone between the propeller 20 and the anchor propeller 19) through the flange tube 14. The detection end directly contacts the material and transmits the pH signal to the control unit module 4. The circular sealing cover 15 and the polytetrafluoroethylene sealing ring 24 cooperate to achieve a seal to prevent leakage. When pH < 6.8, the addition pump 6 at the lower left end of the insulation layer 7 starts and injects alkaline solution. The alkaline solution diffuses rapidly under the radial thrust of the propeller 20 to avoid local over-alkalinity. When pH > 7.6, the addition pump 6 switches to injecting acid solution to adjust the pH. When the pH is in the sensitive range of 6.8-7.6, the control unit module 4 reduces the speed of the drive motor 11 to 100-150 rpm to reduce the generation of bubbles and protect the non-covalent bonds between molecules (such as hydrogen bonds and coordination bonds). After each pH adjustment, the automatic cleaning nozzle 22 at the end of the pH electrode module 16 (at 45° to the electrode axis) starts and rinses the residual material on the electrode surface with high-pressure pure water (0.3MPa). The cleaning waste liquid participates in the reaction with the material circulation. The upper anchor-type propeller 19 (located at 2 / 3 of the height of the inner tank 18) rotates close to the inner wall with Ω-shaped blades, which not only scrapes off the material attached to the side wall to avoid excessive local concentration, but also promotes the exchange between the liquid surface and the gas phase to balance dissolved oxygen. The middle propeller 20 (in the middle of the inner tank 18) generates radial thrust through spiral blades, which quickly mixes acid / alkali solutions with raw materials, ensuring uniform pH adjustment while strengthening molecular collisions and promoting the initial assembly of supramolecular polymers. The lower turbine propeller 21 (at the bottom of the inner tank 18) generates downward thrust with a disc turbine structure, which agitates the deposited type III collagen and other macromolecular components, preventing them from agglomerating and precipitating, ensuring that all raw materials react fully, and finally forming a uniform supramolecular aggregate with a molecular weight of 438kDa-1000kDa. Throughout the process, the control unit module 4 uses a PID algorithm to achieve closed-loop parameter feedback, continuously adjusting the opening of the electric three-way valve 9, the flow rate of the addition pump 6, and the speed of the drive motor 11 to ensure that all parameters remain stable within the preset range until the reaction is complete (duration 2-4 hours, automatically determined according to the raw material ratio). After the reaction is complete, the discharge valve at the bottom of the inner liner 18 (located above the support module 1) is opened, and the supramolecular gel formulation is discharged under gravity. The support module 1 stabilizes the equipment with four support rods with anti-slip pads 2 to prevent shaking during discharge. If continuous production is carried out, the system automatically starts the cleaning program, completing internal cleaning through automatic cleaning nozzles 22 and media circulation to prepare for the next batch of reaction.

[0032] Structural Description: Support Module 1: Composed of 4 stainless steel support rods, vertically fixed to the bottom of the insulation layer, bearing the weight of the entire device and ensuring equipment stability by distributing the force; Anti-slip mat 2: Made of nitrile rubber, it is a circular sheet that is fixed to the lower end of the four support rods of the bracket module to increase the friction with the ground, prevent the equipment from shifting due to vibration during operation, and buffer the vibration. L-shaped bracket 3: Welded from 316L stainless steel angle steel, one end is vertically fixed to the outer wall of the right end of the insulation layer, and the other end extends horizontally, providing a stable mounting carrier for the control unit module and placing the operating interface at a height that is easy to observe. Control Unit Module 4: Composed of a PLC controller, touch screen and relays, it is fixed to the horizontal end of the L-shaped bracket, receives signals from various sensors, and uses PID algorithm to regulate the drive motor, add pumps and other components to achieve fully automatic response control; Medium outlet valve 5: It is a stainless steel check valve, one end of which is connected to the heating jacket and the other end is connected to the pipeline below the additive pump. It controls the discharge of the heating medium and prevents backflow of the medium. The pressure resistance value is not less than 0.6MPa. Add pump 6: This is a two-way metering pump, fixed at the lower left end of the insulation layer. It is connected to the upper part of the inner tank through a pipeline to accurately deliver acid / alkali solutions and adjust the pH value of the reaction system. The end of the pipeline extends 3-5cm below the liquid surface to avoid splashing. Insulation layer 7: Made of polyurethane foam, it is fitted onto the outside of the heating jacket to reduce heat exchange between the heating jacket and the outside environment, maintain a stable reaction temperature, and reduce energy consumption. Medium inlet pipe 8: It is a φ32mm stainless steel pipe, with one end connected to the heating jacket and the other end installed with an electric three-way valve to deliver heating or cooling medium to the heating jacket, providing a carrier for temperature regulation of the inner tank; Electric three-way valve 9: Installed at the input end of the medium inlet pipe, it controls the switching of the passage through a solenoid valve and switches the flow direction of the heating / cooling medium according to the temperature signal to realize the dynamic adjustment of the inner tank temperature; Flange 10: It is a 316L stainless steel flange, fixed to the upper end face of the insulation layer, and connected to the drive motor by screws to ensure the coaxiality of the drive motor and the rotating shaft and reduce vibration during operation; Drive motor 11: It is a variable frequency geared motor, fixed above the flange, and its output end is connected to the rotating shaft to provide power to the stirring paddle. The mixing intensity of the material is controlled by adjusting the speed. Air vent valve 12: This is a one-way exhaust valve, fixed to the upper end of the insulation layer and extending into the inner liner, to exhaust the air brought in during feeding and prevent air bubbles from interfering with the formation of non-covalent bonds between molecules; Sensor assembly 13: Composed of a stainless steel sleeve and a fixing flange, which are installed at the lower end of the insulation layer and the outer wall respectively to fix the PT100 temperature probe, and at the same time prevent material leakage through the sealing structure. Flange tube 14: A stainless steel tube with a flange, fixed to the rear end of the insulation layer, providing an insertion channel for the pH electrode module, and working with the circular sealing cap to enable pluggable installation of the electrode; Circular sealing cap 15: Made of polytetrafluoroethylene, it is fixed to the front end of the flange tube by bolts to seal the gap between the PH electrode module and the flange tube and prevent the material inside the inner tank from leaking out. pH electrode module 16: It consists of a glass electrode and a signal transmission line, which is inserted into the flange tube and the circular sealing cover. The end extends into the middle of the inner tank to monitor the pH value of the reaction system in real time and provide data for acid-base adjustment. Heating jacket 17: It is a double-layer stainless steel cavity that is fitted onto the outside of the inner liner. It heats or cools the inner liner through medium circulation, and precisely controls the reaction temperature. Inner liner 18: A 316L stainless steel container located inside the heating jacket, serving as a reaction chamber for supramolecular gel formulations, providing space for raw material mixing and reaction; Anchor-type paddle 19: It is an Ω-shaped stainless steel paddle blade, fixed to the upper end of the rotating shaft (2 / 3 of the height of the inner tank), to scrape off the attached material on the side wall of the inner tank, avoid excessive local concentration, and promote gas-liquid exchange at the liquid surface. Propeller 20: It consists of spiral stainless steel blades fixed in the middle of the rotating shaft (at 1 / 2 of the inner tank height), generating radial thrust to quickly mix acid / alkali solutions with raw materials and ensure uniform pH adjustment; Turbine propeller 21: It is a disc-shaped stainless steel propeller blade, fixed at the lower end of the rotating shaft (1 / 4 of the height of the inner tank), which generates downward thrust to stir up the large molecular raw materials deposited at the bottom and prevent them from agglomerating and settling. Automatic cleaning nozzle 22: This is a copper nozzle, fixed at the end of the pH electrode module at a 45° angle to the electrode axis. It uses high-pressure pure water to rinse away residual materials on the electrode surface, ensuring the accuracy of pH detection. PT100 temperature probe 23: This is a platinum resistance sensor. It is fixed at different heights inside the inner liner through the sensor assembly to monitor the temperature of different areas inside the inner liner in real time and provide data for the temperature control system. PTFE sealing ring 24: Installed at the contact points between the PT100 temperature probe and the inner liner, and between the pH electrode module and the flange pipe, it achieves sealing through elastic deformation to prevent material leakage and withstand reaction temperatures.

[0033] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A supramolecular biological extract gel preparation device, comprising an inner container (18), a heating jacket (17) and a heat preservation layer (7), characterized in that: A flange (10) is fixedly connected to the upper end of the insulation layer (7), and a drive motor (11) is fixedly connected to the flange (10) by screws. A support module (1) is fixedly connected to the lower part of the insulation layer (7). The support module (1) consists of four support rods, and an anti-slip pad (2) is fixedly connected to the lower part of each support rod. The output end of the drive motor (11) is fixedly connected to a rotating shaft, which is installed inside the inner liner (18). Anchor blade (19), propeller (20) and turbine blade (21) are fixedly connected to the rotating shaft from top to bottom. Multiple sensor assemblies (13) are fixedly installed on the insulation layer (7). Each sensor assembly (13) is fixedly connected to a PT100 temperature probe (23). The end of the PT100 temperature probe (23) is located inside the inner liner (18), and a polytetrafluoroethylene sealing ring (24) is provided at the contact point with the inner wall of the inner liner (18). The rear end of the insulation layer (7) is fixedly connected to a flange pipe (14), and a pH electrode module (16) is inserted into the flange pipe (14). The end of the pH electrode module (16) located inside the inner liner (18) is provided with an automatic cleaning nozzle (22). The front end of the flange pipe (14) is fixedly connected to a circular sealing cover (15) by bolts, and the pH electrode module (16) is also inserted into the circular sealing cover (15). A pump (6) is fixedly connected to the lower left end of the insulation layer (7). A medium outlet valve (5) is provided between the pump (6) and the support module (1). The medium outlet valve (5) is fixedly connected to the heating jacket (17).

2. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 1, characterized in that: The upper end of the insulation layer (7) is provided with an air outlet valve (12), a medium inlet pipe (8) and an electric three-way valve (9). The medium inlet pipe (8) is fixedly connected to the heating jacket (17), and the electric three-way valve (9) is fixedly installed on the medium inlet pipe (8). An L-shaped bracket (3) is fixedly connected to the right end of the insulation layer (7), and a control unit module (4) is fixedly installed on the L-shaped bracket (3).

3. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 2, characterized in that: The anchor paddle (19) is located at 2 / 3 of the height of the inner liner (18), and is in the shape of "Ω". The gap between the edge and the side wall of the inner liner (18) is 1-2 cm. The propeller (20) is located at 1 / 2 of the height of the inner liner (18), and the turbine propeller (21) is located at 1 / 4 of the height of the inner liner (18).

4. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 3, characterized in that: The sensor assembly (13) is provided in three parts, one of which is fixedly connected to the lower end of the insulation layer (7), corresponding to the position of the turbine propeller (21); The other two sensor assemblies (13) are fixedly installed on the outer wall of the insulation layer (7), corresponding to the positions of the anchor paddle (19) and the propeller (20), respectively.

5. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 4, characterized in that: The automatic cleaning nozzle (22) is at a 45° angle to the axis of the pH electrode module (16) and is connected to a food-grade silicone tube.

6. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 5, characterized in that: The addition pump (6) has a bidirectional pump body structure and is connected to the upper part of the inner tank (18) through a pipeline. The end of the pipeline is located next to the feed inlet and extends 3-5cm below the liquid surface.

7. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 6, characterized in that: The control unit module (4) is electrically connected to the drive motor (11), PT100 temperature probe (23), PH electrode module (16), addition pump (6) and electric three-way valve (9), and has a built-in PID algorithm control module.

8. The apparatus for preparing a supramolecular biological extract gel formulation according to claim 7, characterized in that: Both the air outlet valve (12) and the medium outlet valve (5) are one-way valves. The end of the air outlet valve (12) is located inside the inner liner (18), and the pressure resistance of the medium outlet valve (5) is not less than 0.6 MPa.

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