An antibiotic purification device
By designing separate storage hoppers and mixing hoppers, and utilizing a drive motor to drive a worm gear transmission, efficient mixing of large volumes of liquid is achieved during antibiotic extraction. This solves the problem of difficult mixing in existing technologies and simplifies the operation process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- NANJING WANGZHIXING PHARM TECH CO LTD
- Filing Date
- 2025-09-02
- Publication Date
- 2026-08-04
AI Technical Summary
In existing technologies, mixing large volumes of liquid is difficult during antibiotic extraction, and the laboratory equipment capacity is insufficient, making it difficult to achieve effective liquid mixing.
An antibiotic purification device was designed, which adopts a structure of separate storage hopper and mixing hopper. It achieves high-speed mixing of aqueous phase and organic phase through separate conveying wheel and drive motor. The synchronous rotation of worm gear and gear transmission ensures uniform mixing.
It enables efficient mixing and extraction of large volumes of liquids, simplifies the operation process, reduces manpower requirements, and meets the needs of extraction scale-up experiments.
Smart Images
Figure CN224585392U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of antibiotic purification technology, specifically relating to an antibiotic purification device. Background Technology
[0002] The purification process of antibiotics usually starts with fermentation broth. First, it is pretreated by filtering to remove impurities such as mycelium. Then, the active ingredients are extracted by methods such as solvent extraction, ion exchange or adsorption. Next, it is concentrated and desalted by ultrafiltration or reverse osmosis. Then, it is purified by chromatography separation and crystallization to improve purity. Finally, it is dried to obtain a high-purity, high-activity antibiotic product that meets safety standards.
[0003] The extraction process is a crucial part of antibiotic purification. During scale-up experiments, the volume of liquid extracted in a single extraction is large, and the capacity of laboratory separatory funnels is insufficient. Furthermore, it is difficult to manually mix two immiscible liquids thoroughly during large-volume extractions. Therefore, a novel antibiotic purification device is needed. Utility Model Content
[0004] To address the aforementioned problems, this utility model discloses an antibiotic purification device.
[0005] To achieve the above objectives, the technical solution of this utility model is as follows:
[0006] An antibiotic purification device includes a compartmentalized storage hopper with two independent compartments. A separation conveying wheel is rotatably mounted in the outlet pipe of the compartmentalized storage hopper. Two annular conveying sections of the separation conveying wheel are individually connected to the two compartments of the compartmentalized storage hopper. Each annular conveying section has several conveying chambers evenly distributed about the axis of the separation conveying wheel. A worm gear is coaxially fixedly connected to the separation conveying wheel. The worm gear meshes with a vertical worm, and the worm is coaxially connected to a drive motor. A first gear is coaxially connected to the worm, and the first gear meshes with a second gear. A mixing hopper is located below the outlet pipe of the compartmentalized storage hopper, and the second gear is coaxially sleeved on the mixing hopper. A crossbar is rotatably connected to the mixing hopper. A separating hopper is located below the outlet pipe of the mixing hopper. A mounting frame is fixedly connected to the compartmentalized storage hopper, and the mounting frame is fixedly connected to both the separating hopper and the crossbar.
[0007] As a preferred embodiment of this utility model, the drive motor is fixedly connected to the outer wall of the compartmentalized liquid storage hopper.
[0008] In a preferred embodiment of this invention, the drive motor is fixedly connected to the mounting bracket.
[0009] In a preferred embodiment of this invention, the diameter of the first gear is larger than the diameter of the second gear.
[0010] As a preferred embodiment of this invention, the lead angle of the worm is less than or equal to the equivalent friction angle between the worm and the meshing teeth of the worm wheel.
[0011] As a preferred technical solution of this utility model, the mixing hopper is provided with a number of spiral blades forming a number of vertically penetrating spiral channels, and the number of spiral channels are coaxially arranged.
[0012] As a preferred technical solution of this utility model, the outlet pipe of the sub-compartment liquid storage hopper is covered with a cover plate that covers the top opening of the mixing hopper, and the cover plate does not contact the mixing hopper.
[0013] As a preferred embodiment of this invention, the edge of the cover plate is provided with rounded corners to guide the droplets into the inner cavity of the mixing tank.
[0014] As a preferred embodiment of this utility model, the mixing hopper is coaxially fitted with a bearing, and the bearing is embedded in the crossbar.
[0015] The beneficial effects of this utility model are as follows:
[0016] I. The liquid storage hopper of this application is equipped with two independent compartments. Under the conveying of the separation conveyor wheel, the aqueous phase and the organic phase of equal volume can be transported to the high-speed rotating mixing hopper to be broken up and fully mixed. The mixture finally flows into the separating hopper to complete the extraction by layering. This application can realize the extraction of a large volume of liquid in a single operation, which meets the needs of antibiotic extraction scale-up experiments, and there is no need for manual mixing of the extraction liquid.
[0017] Second, this application uses a drive motor to simultaneously drive the separating conveyor wheel and the mixing bucket to rotate, which reduces the need for a power source and achieves synchronous rotation of the separating conveyor wheel and the mixing bucket. They can be started together in a single operation, simplifying the control process. Attached Figure Description
[0018] Figure 1 This is a schematic diagram of the overall structure of an embodiment of the present utility model;
[0019] Figure 2 This is a schematic diagram of the structure of the conveyor wheel, worm gear, worm, drive motor, first gear, and second gear in an embodiment of the present utility model.
[0020] Figure 3 This is a cross-sectional view of the second gear, cover plate, mixing hopper, and bearing in an embodiment of this utility model;
[0021] Figure 4 This is an embodiment of the present utility model. Figure 3 Enlarged view of point A in the middle.
[0022] List of identifiers in attached diagrams:
[0023] 1. Separating liquid storage hopper; 2. Separating conveyor wheel; 201. Circular conveyor section; 3. Worm gear; 4. Worm; 5. Drive motor; 6. First gear; 7. Second gear; 8. Cover plate; 9. Mixing hopper; 10. Bearing; 11. Separating hopper; 12. Mounting frame; 13. Crossbar. Detailed Implementation
[0024] The present invention will be further explained below with reference to the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.
[0025] Please see Figure 1-4 An antibiotic purification device includes a compartmentalized liquid storage hopper 1, which has two independent compartments. A separating conveying wheel 2 is rotatably mounted in the outlet pipe of the compartmentalized liquid storage hopper 1. Two annular conveying sections 201 of the separating conveying wheel 2 are respectively connected to the two compartments of the compartmentalized liquid storage hopper 1, and each annular conveying section 201 has several conveying chambers evenly distributed about the axis of the separating conveying wheel 2. No single conveying chamber can connect vertically to the outlet pipe of the compartmentalized liquid storage hopper 1; the liquid in the compartmentalized liquid storage hopper 1 is conveyed downwards through the rotating conveying chambers. Figure 2 As shown, the area between two adjacent dashed lines in the separating conveyor wheel 2 is an annular conveying section 201. The middle part of the separating conveyor wheel 2 is rotatably connected to the sub-compartment liquid storage hopper 1 via a sealed bearing, or Vaseline can be applied to the rotatable connection between the separating conveyor wheel 2 and the sub-compartment liquid storage hopper 1 to achieve separate communication between the two annular conveying sections 201 and the two sub-compartment liquid storage hoppers 1. A worm gear 3 is coaxially fixedly connected to the separating conveyor wheel 2, and the worm gear 3 meshes with a vertical worm 4, which is coaxially connected to a drive motor 5. A first gear 6 is coaxially connected to the worm 4, and the first gear 6 meshes with a second gear 7. A mixing hopper 9 is provided below the outlet pipe of the sub-compartment liquid storage hopper 1, and the second gear 7 is coaxially sleeved on the mixing hopper 9. A crossbar 13 is rotatably connected to the mixing hopper 9, and a bearing 10 is coaxially sleeved on the mixing hopper 9 and embedded in the crossbar 13 to meet the high-speed rotation requirements of the mixing hopper 9. A separating hopper 11 is installed below the outlet pipe of the mixing hopper 9. A mounting bracket 12 is fixedly connected to the separating hopper 1, and the mounting bracket 12 is also fixedly connected to the separating hopper 11 and the crossbar 13. The main body of the separating hopper 11 is made of transparent material to facilitate the separation process.
[0026] Example 1: The drive motor 5 is fixedly connected to the outer wall of the sub-compartment storage tank 1, as shown in the attached example.
[0027] Example 2: The drive motor 5 is fixedly connected to the mounting bracket 12. The example is not shown in the attached drawings.
[0028] The diameter of the first gear 6 is larger than that of the second gear 7, which is used to change the transmission ratio of the drive motor 5 and increase the speed of the mixing bucket 9.
[0029] The lead angle of the worm 4 is less than or equal to the equivalent friction angle between its meshing teeth and the worm wheel 3. Therefore, only the worm 4 can drive the worm wheel 3, and the worm wheel 3 cannot drive the worm 4. As a result, when the drive motor 5 stops, the separating conveyor wheel 2 cannot rotate, and the liquid storage hopper 1 cannot discharge liquid.
[0030] The mixing hopper 9 is equipped with several spiral blades forming several vertically connected spiral channels, and these spiral channels are coaxially arranged. The rotating spiral blades break up and mix the two immiscible liquids for extraction. The mixed liquid flows downward through the spiral channels and finally flows into the separating hopper 11 for stratification.
[0031] The outlet pipe of the sub-compartment hopper 1 is fitted with a cover plate 8 that covers the top opening of the mixing hopper 9, and the cover plate 8 does not contact the mixing hopper 9. The edge of the cover plate 8 is provided with rounded corners to guide the droplets into the inner cavity of the mixing hopper 9. Therefore, the cover plate 8 does not hinder the high-speed rotation of the mixing hopper 9, and most of the droplets splashed in the mixing hopper 9 will drip back into the mixing hopper 9 after contacting the cover plate 8.
[0032] Working principle:
[0033] During extraction, the aqueous phase and organic phase containing lipid-soluble antibiotics are placed into two independent compartments of the storage hopper 1. Then, the drive motor 5 drives the worm gear 4 to rotate. The worm gear 4 drives the separation conveyor wheel 2 to rotate through the worm wheel 3 meshing with it. The rotating wheel continuously conveys equal volumes of aqueous and organic phases into the mixing hopper 9 through two rotating annular conveyor sections 201. At the same time, the worm gear 4 drives the mixing hopper 9 to rotate at high speed through the coaxial first gear 6 and the second gear 7 meshing with the first gear 6. The aqueous and organic phases flowing into the mixing hopper 9 are broken and mixed by the rotating spiral blades for extraction. The mixed liquid flows downward through the spiral channel and finally flows into the separatory hopper 11 for stratification. The stopcock at the bottom of the separatory hopper 11 is opened to collect the aqueous and organic phases separately to complete the extraction.
[0034] It should be noted that the above content merely illustrates the technical concept of this utility model and cannot be used to limit the scope of protection of this utility model. For those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and all such improvements and modifications fall within the scope of protection of the claims of this utility model.
Claims
1. An antibiotic purification apparatus comprising a compartmented holding hopper (1), characterized in that, The compartmentalized liquid storage hopper (1) is provided with two independent compartments. A separation conveying wheel (2) is rotatably installed in the outlet pipe of the compartmentalized liquid storage hopper (1). The two annular conveying parts (201) of the separation conveying wheel (2) are respectively connected to the two compartments of the compartmentalized liquid storage hopper (1). Each annular conveying part (201) is provided with several conveying cavities evenly distributed about the axis of the separation conveying wheel (2). A worm gear (3) is coaxially fixedly connected to the separation conveying wheel (2). The worm gear (3) meshes with a vertical worm (4), and the worm (4) is coaxially connected to a drive motor. The machine (5) has a first gear (6) coaxially connected to the worm (4), and the first gear (6) meshes with a second gear (7). A mixing hopper (9) is provided below the outlet pipe of the subdivided liquid storage hopper (1), and the second gear (7) is coaxially sleeved on the mixing hopper (9). A crossbar (13) is rotatably connected to the mixing hopper (9). A separating hopper (11) is provided below the outlet pipe of the mixing hopper (9). A mounting frame (12) is fixedly connected to the subdivided liquid storage hopper (1), and the mounting frame (12) is fixedly connected to both the separating hopper (11) and the crossbar (13).
2. An antibiotic purification device according to claim 1, wherein, The drive motor (5) is fixedly connected to the outer wall of the sub-compartment storage tank (1).
3. An antibiotic purification device according to claim 1, wherein, The drive motor (5) is fixedly connected to the mounting bracket (12).
4. An antibiotic purification device according to claim 1, wherein, The diameter of the first gear (6) is greater than the diameter of the second gear (7).
5. The antibiotic purification device of claim 1, wherein, The lead angle of the worm (4) is less than or equal to the equivalent friction angle between it and the meshing teeth of the worm wheel (3).
6. An antibiotic purification device according to claim 1, wherein, The mixing hopper (9) is provided with several spiral blades forming several vertically connected spiral channels, and the several spiral channels are coaxially arranged.
7. An antibiotic purification device according to claim 1, wherein, The outlet pipe of the sub-compartment storage tank (1) is covered with a cover plate (8) that covers the top opening of the mixing tank (9), and the cover plate (8) does not contact the mixing tank (9).
8. An antibiotic purification device according to claim 7, wherein, The edge of the cover plate (8) is provided with rounded corners to guide droplets into the inner cavity of the mixing bucket (9).
9. The antibiotic purification device of claim 1, wherein, The mixing hopper (9) is coaxially fitted with a bearing (10), and the bearing (10) is embedded in the crossbar (13).