Modular switched solvent mixing guard integrated column

Abstract

This invention provides a modularly switchable integrated column for solvent mixing and protection, comprising an upper shell, inside which is a column core assembly. The column core assembly includes a solvent effect elimination module and a protection column module. The solvent effect elimination module includes a filter shell, a cavity mixer, and a raised filter. Both the raised filter and the cavity mixer are installed inside the filter shell. By incorporating the solvent effect elimination module, this invention ensures thorough solvent mixing, preventing retention anomalies caused by localized solvent differences, thereby eliminating solvent effects and guaranteeing the reliability of results. The protection column module intercepts impurities and contaminants in the mobile phase, providing strong protection for the chromatographic column and extending its lifespan. Furthermore, the modular design of the column core assembly allows for individual or combined installation of the solvent effect elimination module and the protection column module, enriching functionality and meeting diverse application needs.

Description

Technical Field

[0001] This utility model relates to an integrated column, specifically a modularly switchable solvent mixing protection integrated column, belonging to the technical field of solvent mixing protection integrated columns. Background Technology

[0002] A guard column is a small pretreatment device installed at the front end of the analytical column (or other core separation component) in a chromatographic system. Its main function is to protect the core analytical component from harmful components in the sample or mobile phase. It is typically filled with a material similar in properties to the analytical column packing or with specific adsorption capabilities. This material can retain particulate matter, highly retained impurities, salts, and other substances in the sample, as well as contaminants that may be present in the mobile phase. This prevents these components from entering the analytical column and causing blockage, column head contamination, or packing degradation, thereby extending the column's lifespan, reducing system maintenance frequency, and ensuring the stability and reliability of chromatographic analysis results.

[0003] Existing guard columns have limited functionality and lack the ability to eliminate solvent effects. Once solvent effects occur, the retention behavior of sample components within the chromatographic column will become abnormal, leading to problems such as peak broadening, splitting, or retention time drift. This interferes with the normal separation of components on the analytical column, reduces the accuracy and repeatability of chromatographic analysis, and ultimately affects the reliability of experimental results. To address this, a modularly switchable solvent mixing guard column is proposed. Utility Model Content

[0004] In view of this, the present invention provides a modularly switchable solvent mixing protection integrated column to solve or alleviate the technical problems existing in the prior art, and at least provides a beneficial option.

[0005] The technical solution of this utility model embodiment is implemented as follows: a modularly switchable solvent mixing protection integrated column includes an upper shell, and a column core assembly is disposed inside the upper shell. The column core assembly includes a solvent effect elimination module and a protection column module. The solvent effect elimination module includes a filter shell, a cavity mixer, and a bossed filter. Both the raised filter and the cavity mixer are installed inside the filter housing. The surface of the raised filter is provided with a contact raised surface and a groove. The groove is annular and located outside the contact raised surface. The surface of the cavity mixer is provided with a chamber. The inner wall of the chamber is provided with three swirling grooves distributed in annularly. The inner wall of the chamber is provided with a discharge hole that penetrates the lower surface of the cavity mixer. The protective column module includes a column tube and packing material; The filler is uniformly filled inside the column tube.

[0006] More preferably, a conduit base is installed inside the upper shell, and a lower shell is installed at the bottom of the upper shell.

[0007] More preferably, the core assembly is located inside the upper and lower shells.

[0008] More preferably, the far ends of the solvent effect elimination module and the protective pillar module abut against the lower shell and the conduit base, respectively, and the adjacent ends of the solvent effect elimination module and the protective pillar module abut against each other.

[0009] More preferably, a conduit is installed inside the conduit base, and a blade ring is installed on the outer wall of the conduit.

[0010] More preferably, a telescopic head is installed at the bottom of the outer side wall of the blade ring.

[0011] More preferably, the telescopic head is mounted on the top of the upper shell.

[0012] More preferably, the connection between the upper shell and the lower shell is a threaded connection, a snap-fit ​​connection, or a riveting connection.

[0013] The present invention has the following advantages due to the adoption of the above technical solution: This invention allows for the installation of the solvent effect elimination module and the protective column module according to functional requirements: when both solvent effect elimination and protective column functions are required simultaneously, both modules are installed; when only solvent effect elimination is needed, only the solvent effect elimination module is installed; and when only the protective column function is needed, only the protective column module is installed. Compared to existing technologies, this invention, by incorporating the solvent effect elimination module, ensures thorough solvent mixing, preventing retention anomalies caused by local solvent differences, thereby eliminating the solvent effect and guaranteeing the reliability of the results. Furthermore, the modular design of the column core assembly allows for the separate or combined installation of the solvent effect elimination module and the protective column module, enriching functionality and meeting diverse usage needs.

[0014] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the present invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a cross-sectional view of the present invention; Figure 2 This is a structural diagram of the present invention when the solvent effect elimination module is installed separately; Figure 3 This is a structural diagram of the present invention when the protective column module is installed separately; Figure 4 This is a top view of the cavity mixer of this utility model; Figure 5 This is a cross-sectional view of the boss filter element of this utility model.

[0017] Reference numerals: 101, Core assembly; 10, Solvent effect elimination module; 11, Filter shell; 12, Chamber mixer; 121, Chamber; 122, Swirl groove; 123, Discharge hole; 13, Bossed filter; 131, Contact boss; 132, Groove; 20, Protective column module; 21, Column tube; 22, Packing; 31, Conduit; 32, Blade ring; 33, Telescopic head; 34, Upper shell; 35, Conduit base; 36, Lower shell. Detailed Implementation

[0018] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of this invention. Therefore, the drawings and description are considered exemplary in nature and not restrictive.

[0019] The embodiments of this utility model will now be described in detail with reference to the accompanying drawings.

[0020] like Figures 1-5 As shown, this utility model embodiment provides a modularly switchable solvent mixing protection integrated column, including an upper shell 34, and a column core assembly 101 is disposed inside the upper shell 34. The column core assembly 101 includes a solvent effect elimination module 10 and a protection column module 20. Solvent effect elimination module 10 includes filter shell 11, cavity mixer 12 and boss filter 13; Both the protruding filter 13 and the cavity mixer 12 are installed inside the filter housing 11. The surface of the protruding filter 13 is provided with a contact protrusion 131 and a groove 132. The groove 132 is annular and located outside the contact protrusion 131. When the liquid flows and comes into contact with the protruding filter 13, the liquid first contacts the contact protrusion 131, and then flows down from the top through the groove 132. During the process of passing through the groove 132, the liquid will generate backflow and turbulent flow phenomena. Then the liquid will penetrate to the lower layer through the filter, thereby effectively improving the mixing efficiency. The surface of the cavity mixer 12 is provided with a chamber 121. The inner wall of the chamber 121 is provided with three swirling grooves 122 arranged in a ring. The inner wall of the chamber 121 is provided with a discharge hole 123. The discharge hole 123 penetrates the lower surface of the cavity mixer 12. When the liquid flows and comes into contact with the cavity mixer 12, the liquid enters the chamber 121 and generates swirling flow along the swirling grooves 122, which can accelerate the mixing of the solvent. Then the solvent is discharged from the discharge hole 123 into the lower cavity mixer 12. The pressure difference between the discharge hole and the lower chamber 121 makes the liquid sprayed into the lower chamber 121 mix more thoroughly. Furthermore, the solvent effect elimination module 10 enables the solvent to be fully mixed to eliminate the solvent effect. By mixing, the properties (such as elution capacity and polarity) of the sample solvent and mobile phase are quickly made uniform, avoiding local retention abnormalities caused by solvent differences, thereby eliminating the solvent effect.

[0021] The protective column module 20 includes a column tube 21 and packing 22; The packing material 22 is uniformly filled inside the column tube 21. The packing material 22 can trap particulate matter, highly retained impurities, salts and other substances in the liquid sample.

[0022] In one embodiment, a conduit base 35 is installed inside the upper shell 34, and a lower shell 36 is installed at the bottom of the upper shell 34. The core assembly 101 is located inside the upper shell 34 and the lower shell 36. The far ends of the solvent effect elimination module 10 and the protective column module 20 abut against the lower shell 36 and the conduit base 35, respectively. The adjacent ends of the solvent effect elimination module 10 and the protective column module 20 abut against each other. The shape of the bottom of the conduit base 35 is adapted to the shape of the end of the filter shell 11 and the end of the column tube 21. It can be a slope, an arc surface or a stepped surface, thereby ensuring the sealing effect. During use, when both solvent effect elimination and guard column functions need to be satisfied simultaneously, the guard column module 20 is installed in the upper shell 34, and the solvent effect elimination module 10 is installed in the lower shell 36. Then, the lower shell 36 is connected to the upper shell 34, and the adjacent ends of the solvent effect elimination module 10 and the guard column module 20 are in contact. At this time, when a solvent sample is introduced, the sample flows in from the bottom end of the lower shell 36. The liquid sample flow will first contact the solvent effect elimination module 10, and then contact the guard column module 20. Thus, while eliminating the solvent effect, it can also retain particulate matter, highly retained impurities, salts and other substances in the sample solution. At this time, the lower shell 36 is a long lower shell 36 that is adapted to the length of the solvent effect elimination module 10 and the guard column module 20. When only the function of eliminating solvent effect is required, the solvent effect elimination module 10 is directly loaded into the upper shell 34, and then the lower shell 36 is connected to the upper shell 34. The lower shell 36 abuts against the bottom end of the solvent effect elimination module 10, and the top end of the solvent effect elimination module 10 abuts against the tube base 35. At this time, when a solvent sample is introduced, the solvent effect can be eliminated. At this time, the lower shell 36 is a short lower shell 36 that is adapted to the length of the solvent effect elimination module 10. When the protective column function is required, the protective column module 20 is directly loaded into the upper shell 34, and then the lower shell 36 is connected to the upper shell 34. The lower shell 36 abuts against the bottom end of the protective column module 20, and the top end of the protective column module 20 abuts against the conduit base 35. At this time, the solvent effect can be eliminated when the solvent sample is introduced. At this time, the lower shell 36 is a short lower shell 36 that is adapted to the length of the protective column module 20.

[0023] In one embodiment, a conduit 31 is installed inside the conduit base 35, a blade ring 32 is installed on the outer wall of the conduit 31, a telescopic head 33 is installed at the bottom of the outer wall of the blade ring 32, and the telescopic head 33 is installed on the top of the upper shell 34. The telescopic head 33 can adapt to the length of most conduits on the market without generating dead volume.

[0024] In one embodiment, the upper shell 34 and the lower shell 36 are connected by a threaded connection, a snap-fit ​​connection, or a riveting, which facilitates the disassembly or assembly of the upper shell 34 and the lower shell 36.

[0025] In operation, this utility model involves installing the solvent effect elimination module 10 and the protective column module 20 according to functional requirements. When it is necessary to simultaneously satisfy the functions of eliminating solvent effect and protecting the column, the protective column module 20 and the solvent effect elimination module 10 are respectively installed between the upper shell 34 and the lower shell 36. When the solvent effect elimination function is required, the solvent effect elimination module 10 is installed between the upper shell 34 and the lower shell 36; When the protection pillar function needs to be met, the protection pillar module 20 is installed between the upper shell 34 and the lower shell 36; After loading is complete, the sample solution is delivered into the lower shell 36. The sample solution flows through the solvent effect elimination module 10 or the protective column module 20, or both, and then flows out from the upper shell 34. Compared with the prior art, this utility model can generate backflow and turbulent flow phenomena under the action of the raised filter 13 when liquid solvent is introduced, thereby effectively improving the mixing efficiency. By setting the solvent effect elimination module 10, the solvent can be fully mixed, avoiding local retention abnormalities caused by solvent differences, thereby eliminating the solvent effect and ensuring the reliability of the results. Moreover, the column core assembly 101 adopts a modular design, which allows the solvent effect elimination module 10 and the protective column module 20 to be installed separately or in combination, enriching the functions and meeting different usage needs.

[0026] The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in this utility model, and these should all be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the protection scope of the claims.

Claims

1. A modularly switchable solvent mixing protection integrated column, comprising an upper shell (34), characterized in that: The upper shell (34) is provided with a core assembly (101), which includes a solvent effect elimination module (10) and a protective column module (20). The solvent effect elimination module (10) includes a filter shell (11), a cavity mixer (12), and a boss filter (13). The protruding filter (13) and the cavity mixer (12) are both installed inside the filter shell (11). The surface of the protruding filter (13) is provided with a contact protrusion (131) and a groove (132). The groove (132) is annular and located outside the contact protrusion (131). The surface of the cavity mixer (12) is provided with a cavity (121). The inner wall of the cavity (121) is provided with three swirling grooves (122) distributed in annularly. The inner wall of the cavity (121) is provided with a discharge hole (123). The discharge hole (123) penetrates the lower surface of the cavity mixer (12). The protective column module (20) includes a column tube (21) and a packing (22); The filler (22) is uniformly filled inside the column tube (21).

2. The modularly switchable solvent mixing protection integrated column according to claim 1, characterized in that: The upper shell (34) has a wire base (35) installed inside, and the lower shell (36) is installed at the bottom of the upper shell (34).

3. The modularly switchable solvent mixing protection integrated column according to claim 2, characterized in that: The core assembly (101) is located inside the upper shell (34) and the lower shell (36).

4. The modularly switchable solvent mixing protection integrated column according to claim 2, characterized in that: The far ends of the solvent effect elimination module (10) and the protective pillar module (20) respectively abut against the lower shell (36) and the conduit base (35), and the adjacent ends of the solvent effect elimination module (10) and the protective pillar module (20) abut against each other.

5. The modularly switchable solvent mixing protection integrated column according to claim 4, characterized in that: The conduit base (35) has a conduit (31) installed inside, and a blade ring (32) is installed on the outer wall of the conduit (31).

6. The modularly switchable solvent mixing protection integrated column according to claim 5, characterized in that: A telescopic head (33) is installed at the bottom of the outer side wall of the blade ring (32).

7. The modularly switchable solvent mixing protection integrated column according to claim 6, characterized in that: The telescopic head (33) is mounted on the top of the upper shell (34).

8. The modularly switchable solvent mixing protection integrated column according to claim 2, characterized in that: The upper shell (34) and the lower shell (36) are connected by threaded connection, snap-fit ​​connection or riveting.

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