A filling and sealing device for doxorubicin hydrochloride liposome injection

Abstract

The utility model relates to liquid filling technical field especially is a kind of doxorubicin hydrochloride liposome injection filling capping device, including turntable, the bottom motor of the bottom fixedly connected of turntable, the middle part rotationally connected of turntable has support column, the top fixedly connected of support column has top plate, the top of turntable is evenly provided with a plurality of first empty slot and second empty slot, and the clamping assembly for clamping and fixing bottle is set in first empty slot and second empty slot. The utility model drives first rotating rod to rotate by motor, drives second rotating rod to rotate by rotating first rotating rod, when second rotating rod rotates, it can drive fixed plate to move, when fixed plate moves, it can be assisted by slider cooperation slide rail to be in line with moving direction, when fixed plate moves, it can drive support plate, second fixed frame and gyro wheel to move together, the position of second fixed frame and gyro wheel can be adjusted to adapt to more size bottle, to satisfy more production demand.

Description

TECHNICAL FIELD

[0001] The utility model relates to liquid filling technical field especially relates to a doxorubicin hydrochloride liposome injection filling and capping device. BACKGROUND

[0002] Doxorubicin hydrochloride liposome injection (doxorubicin) is a modified chemotherapy drug, belongs to anthracycline antibiotics, and is mainly used for treating ovarian cancer, multiple myeloma, kaposi's sarcoma and other malignant tumors. It reduces the cardiotoxicity of traditional doxorubicin through liposome wrapping technology, prolongs the circulation time of the drug in the blood, and improves the targeting. In order to facilitate use, filling is usually carried out.

[0003] The filling and capping device disclosed in the Chinese patent with the authorized announcement number CN211198546U has the working principle of "including: a filling valve, the filling valve includes: a filling valve body, the bottom of the filling valve body is provided with a valve nozzle, a bottle clamp is arranged below the filling valve, the bottle clamp is fixed with the filling valve through a connecting piece, a capping block is arranged between the filling valve and the bottle clamp, the capping block is provided with a cover mold cavity capable of accommodating a bottle cap, a through hole is formed in the top of the capping block, an elastic clamping mechanism is arranged on the capping block, the elastic clamping mechanism can clamp the bottle cap in the cover mold cavity, the capping block is connected with a lifting driving mechanism, and under the driving of the lifting driving mechanism, the capping block can move upwards to make the valve nozzle extend into the cover mold cavity or move downwards to make the bottle cap in the cover mold cavity press the bottle mouth of the bottle clamped by the bottle clamp. The utility model has the advantages that the filling and capping are integrated, a capping machine does not need to be separately arranged, the occupied space of the equipment of the filling production line is greatly reduced, and the manufacturing, use and management costs of the filling production line are effectively reduced".

[0004] It mainly integrates the filling and capping, reduces the equipment occupied space, and reduces the production cost, but in actual operation, the capacity of the bottle is not fixed, if the bottle needs to be fixed, the equipment needs to be disassembled to replace the adaptive clamping structure, which not only wastes time and effort, but also increases the labor intensity, and replacing different clamping structures also increases the production cost. UTILITY MODEL CONTENTS

[0005] In view of the deficiencies in the prior art, the utility model provides the following technical scheme:

[0006] A doxorubicin hydrochloride liposome injection filling and capping device, comprising a turntable, a bottom motor fixedly connected to the bottom of the turntable, a support column rotationally connected to the middle part of the turntable, a top plate fixedly connected to the top of the support column, a plurality of first and second empty slots are formed in the top of the turntable, and a clamping assembly for clamping and fixing a bottle is arranged in each of the first and second empty slots.

[0007] As the improvement of the above technical scheme, the clamping assembly comprises a motor, the output end of the motor is fixedly connected with a first rotating rod, the two ends of the first rotating rod are both rotatably connected with a second rotating rod, the other end of the second rotating rod is rotatably connected to the bottom of a fixed plate, the bottom of the fixed plate is symmetrically fixedly connected with a sliding block, the sliding block is slidably connected to the outer side of a sliding rail, the top of the fixed plate is fixedly connected with a supporting plate, one side of the supporting plate is symmetrically fixedly connected with a second fixing frame, and a roller is rotatably connected in the second fixing frame.

[0008] As the improvement of the above technical scheme, the rotating table is provided with a conveying table, one end of the conveying table is provided with a first fixing frame, the top end of the first fixing frame is provided with a plurality of sterilization lamps, and one side of the first fixing frame is symmetrically fixedly connected with a pneumatic cylinder.

[0009] As the improvement of the above technical scheme, the top of one end of the conveying table is provided with a conveying belt, one side of the top of the conveying table is provided with a first baffle, the other side of the top of the conveying table is provided with a second baffle, one end of the second baffle is rotatably connected with a third baffle, the other end of the third baffle is rotatably connected with a fourth baffle, the outer side of the fourth baffle is symmetrically provided with a connecting rod, and the other end of the connecting rod is fixedly connected to the output end of the pneumatic cylinder.

[0010] As the improvement of the above technical scheme, the inner sides of the first baffle, the second baffle, the third baffle and the fourth baffle are rotatably connected with a plurality of rotating rollers, and the other end of the top of the conveying table is provided with a plurality of rollers.

[0011] As the improvement of the above technical scheme, the bottom of the top plate is uniformly provided with a plurality of filling pieces and capping pieces, the bottom of the top plate is provided with a cleaning piece, and one side of the cleaning piece is provided with a blowing piece.

[0012] The beneficial effects of the present application are as follows:

[0013] The first rotating rod at the output end of the motor is driven to rotate by the motor, the second rotating rods at the two ends of the first rotating rod are driven to rotate by the rotation of the first rotating rod, the fixed plate connected with the second rotating rods is driven to move when the second rotating rods rotate, the moving direction of the fixed plate is adjusted by the sliding block at the bottom of the fixed plate cooperating with the sliding rail, so that the fixed plate can only move horizontally and cannot deviate, and the supporting plate, the second fixing frame and the roller at the top of the fixed plate are driven to move together when the fixed plate moves, the positions of the second fixing frame and the roller can be adjusted to adapt to more sizes of bottles, so as to meet more production requirements. BRIEF DESCRIPTION OF DRAWINGS

[0014] Fig. 1 The structure of the present application is shown in the figure;

[0015] Fig. 2It is the structure schematic view of the filling piece in the utility model.

[0016] Fig. 3 It is the structure schematic view of the roller in the utility model.

[0017] Fig. 4 It is the structure schematic view of the clamping assembly in the utility model.

[0018] The drawings show that the utility model discloses a kind of filling and sealing devices for doxorubicin hydrochloride liposome injection, including rotary table 1, the bottom of rotary table 1 is fixedly connected with bottom motor 18, the middle part of rotary table 1 is rotatably connected with support column 12, the top of support column 12 is fixedly connected with top plate 3, the top of rotary table 1 is provided with a plurality of first empty slot 2 and second empty slot 13, and clamping assembly for clamping and fixing bottle is arranged in first empty slot 2 and second empty slot 13. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical scheme and advantage of the utility model more clear and obvious, the following will be further detailed.The specific embodiments described herein are intended to explain the utility model only and are not intended to limit the utility model.

[0020] Please refer to Figs. 1-4 , a kind of doxorubicin hydrochloride liposome injection filling and sealing device, including rotary table 1, the bottom of rotary table 1 is fixedly connected with bottom motor 18, the middle part of rotary table 1 is rotatably connected with support column 12, the top of support column 12 is fixedly connected with top plate 3, the top of rotary table 1 is provided with a plurality of first empty slot 2 and second empty slot 13, and clamping assembly for clamping and fixing bottle is arranged in first empty slot 2 and second empty slot 13.

[0021] Specifically, rotary table 1 can be driven to rotate outside support column 12 by bottom motor 18, so that the position of first empty slot 2 and second empty slot 13 on rotary table 1 is adjusted conveniently, and then the bottle is clamped and fixed by clamping assembly, so that subsequent filling and sealing operations are facilitated, wherein second empty slot 13 is not a fixed position, when no external components are arranged above it, this empty slot is second empty slot 13, which is arranged to facilitate the external gripping structure to take away the bottle filled and sealed.

[0022] Please refer to Figs. 1-4The clamping assembly comprises a motor 23, the output end of the motor 23 is fixedly connected with a first rotating rod 24, both ends of the first rotating rod 24 are rotatably connected with a second rotating rod 25, the other end of the second rotating rod 25 is rotatably connected with the bottom of a fixed plate 26, the bottom of the fixed plate 26 is symmetrically fixedly connected with a sliding block 27, the sliding block 27 is slidably connected with the outer side of a sliding rail 28, the top of the fixed plate 26 is fixedly connected with a supporting plate 29, one side of the supporting plate 29 is symmetrically fixedly connected with a second fixing frame 30, the second fixing frame 30 is rotatably connected with a roller 31.

[0023] Specifically, the first rotating rod 24 at the output end of the motor 23 is driven to rotate, the second rotating rod 25 at both ends of the first rotating rod 24 is driven to rotate by rotating the first rotating rod 24, when the second rotating rod 25 rotates, the fixed plate 26 connected with the second rotating rod 25 is driven to move, when the fixed plate 26 moves, the sliding block 27 at the bottom of the fixed plate 26 cooperates with the sliding rail 28 to correct the moving direction, so that the fixed plate 26 can only move horizontally and cannot be deviated, when the fixed plate 26 moves, the supporting plate 29, the second fixing frame 30 and the roller 31 at the top of the fixed plate 26 move together, by adjusting the positions of the second fixing frame 30 and the roller 31, more sizes of bottles can be adapted, so as to meet more production requirements, at the same time, the structure can also improve the positioning accuracy and guarantee the stability during the capping and sealing, the roller 31 can be made of soft material, which can reduce the risk of damage to the bottle body during extrusion and fixation.

[0024] Please refer to Figs. 1-4 One side of the rotating table 1 is provided with a conveying table 6, one end of the outer side of the conveying table 6 is provided with a first fixing frame 4, the top end of the first fixing frame 4 is provided with a plurality of sterilization lamps 21, one side of the first fixing frame 4 is symmetrically fixedly connected with a pneumatic cylinder 5, the top of one end of the conveying table 6 is provided with a conveying belt 11, one side of the top of the conveying table 6 is provided with a first baffle 7, the other side of the top of the conveying table 6 is provided with a second baffle 9, one end of the second baffle 9 is rotatably connected with a third baffle 10, the other end of the third baffle 10 is rotatably connected with a fourth baffle 19, the outer side of the fourth baffle 19 is symmetrically provided with a connecting rod 20, the other end of the connecting rod 20 is fixedly connected with the output end of the pneumatic cylinder 5, a plurality of rotating rollers 8 are rotatably connected with the inner sides of the first baffle 7, the second baffle 9, the third baffle 10 and the fourth baffle 19, and a plurality of roller cylinders 22 are provided on the other end of the top of the conveying table 6.

[0025] Specifically, a large number of empty bottles can be transported to the first fixed frame 4 below the conveying belt 11, above the roller 22 at the other end of the top of the conveying table 6, and the empty bottles are sequentially sent one by one into the first empty slot 2 through the cooperation of the first baffle 7, the second baffle 9, the third baffle 10 and the fourth baffle 19, wherein the distance between the fourth baffle 19 and the first baffle 7 is adjusted by moving the connecting rod 20 at the output end of the air cylinder 5 and the fourth baffle 19 to adapt to bottles of different sizes, and when the fourth baffle 19 is moved, the third baffle 10 connected thereto is rotated to adjust the position, and the rotating roller 8 facilitates the movement of the bottles, and the rotating roller 8 is also made of soft material to reduce damage to the bottles caused by impact, and when the bottles are transported above the roller 22, the sterilization lamp 21 performs sterilization and disinfection treatment on the bottles, which is prior art and will not be described in detail.

[0026] Please refer to Figs. 1-4 The bottom of the top plate 3 is uniformly provided with a plurality of filling elements 14 and capping elements 15, and the bottom of the top plate 3 is provided with a cleaning element 16, and one side of the cleaning element 16 is provided with a blowing element 17.

[0027] Specifically, the bottles are transported into the first empty slot 2 and clamped and fixed by the clamping assembly and located below the filling element 14, and the bottles are injected with liposome doxorubicin hydrochloride liquid through the downward movement of the filling element 14, and after filling is completed, there may be a little liquid remaining at the bottle opening, at which time the bottles are moved to below the cleaning element 16 and the blowing element 17 by the rotation of the turntable 1, the cleaning element 16 is lowered to the bottle opening to rotate to clean the liquid at the bottle opening, and is blown by the blowing element 17, wherein the cleaning element 16 can adopt a sterile sponge brush assembly, and the blowing element 17 adopts high-pressure sterile gas flow, the bottles after secondary cleaning and disinfection are rotated to below the capping element 15 for capping treatment, and finally are rotated to the second empty slot 13 to be taken away by the external gripping structure.

[0028] The above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them.

Claims

1. A filling and capping device for doxorubicin hydrochloride liposome injection, comprising a turntable (1), characterized in that: The bottom of the turntable (1) is fixedly connected to a bottom motor (18), the middle of the turntable (1) is rotatably connected to a support column (12), the top of the support column (12) is fixedly connected to a top plate (3), and the top of the turntable (1) is provided with several first slots (2) and second slots (13). The first slots (2) and the second slots (13) are each provided with clamping components for clamping and fixing bottles. The clamping assembly includes a motor (23), the output end of which is fixedly connected to a first rotating rod (24), both ends of which are rotatably connected to a second rotating rod (25), the other end of which is rotatably connected to the bottom of a fixed plate (26), a slider (27) is symmetrically fixedly connected to the bottom of the fixed plate (26), the slider (27) is slidably connected to the outside of a slide rail (28), a support plate (29) is fixedly connected to the top of the fixed plate (26), a second fixing frame (30) is symmetrically fixedly connected to one side of the support plate (29), and a roller (31) is rotatably connected inside the second fixing frame (30).

2. The filling and capping device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: A conveying platform (6) is provided on one side of the turntable (1), and a first fixing frame (4) is provided on the outer side of one end of the conveying platform (6). Several sterilization lamps (21) are provided at the top of the first fixing frame (4), and cylinders (5) are symmetrically fixedly connected to one side of the first fixing frame (4).

3. The filling and capping device for doxorubicin hydrochloride liposome injection according to claim 2, characterized in that: A conveyor belt (11) is provided at the top of one end of the conveying platform (6). A first baffle (7) is provided on one side of the top of the conveying platform (6). A second baffle (9) is provided on the other side of the top of the conveying platform (6). A third baffle (10) is rotatably connected to one end of the second baffle (9). A fourth baffle (19) is rotatably connected to the other end of the third baffle (10). A connecting rod (20) is symmetrically provided on the outer side of the fourth baffle (19). The other end of the connecting rod (20) is fixedly connected to the output end of the cylinder (5).

4. The filling and capping device for doxorubicin hydrochloride liposome injection according to claim 3, characterized in that: The inner sides of the first baffle (7), the second baffle (9), the third baffle (10) and the fourth baffle (19) are all rotatably connected with several rotating rollers (8), and the other end of the top of the conveying platform (6) is provided with several rollers (22).

5. The filling and capping device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: The bottom of the top plate (3) is evenly provided with a number of filling parts (14) and sealing parts (15), and the bottom of the top plate (3) is provided with a cleaning part (16), and a blowing part (17) is provided on one side of the cleaning part (16).

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