An oral ulcer patch
CN224686095UActive Publication Date: 2026-08-28NINGXIA MEDICAL UNIVERSITY GENERAL HOSPITAL
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Patent Information
- Application Number
- CN202521831515.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-27
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2035-08-27
AI Technical Summary
Technical Problem
[0002]消费者对口腔健康重视程度不断提高，现有口腔溃疡贴片粘附性差，且药物释放不可控，无法根据溃疡微环境动态调节
Benefits of technology
[0018]本实用新型的有益效果是：本实用新型载药基质中设置pH响应微球，采用聚丙烯酸壳作为微球的包覆球壳，随酸性值的变化而改变释药速率，聚丙烯酸在酸性环境下羧载药基质子化，随pH减小，分子链收缩，分子间孔隙增大，从而加速聚丙烯酸壳内的药物释放速率；聚丙烯酸在中性环境下去质子化，分子链舒展，分子间孔隙减小，从而减缓聚丙烯酸壳内的药物释放速率；通过设置ROS响应微球，采用聚多巴胺壳作为微球的包覆球壳，在高浓度活性氧下降解，聚多巴胺的邻苯二酚基团会被高浓度活性氧氧化为醌式结构，使得聚多巴胺酯降解，释放聚多巴胺壳内的药物，从而能够实现释药速率的自主调节。
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Figure CN224686095U_ABST
Abstract
The utility model discloses a kind of oral ulcer patches, belong to medical field, including drug-loading layer;Drug-loading layer includes drug-loading matrix, pH response microsphere and ROS response microsphere, pH response microsphere and ROS response microsphere are dispersedly embedded in drug-loading matrix;Among them, pH response microsphere includes polyacrylic acid shell and the drug in polyacrylic acid shell;ROS response microsphere includes polydopamine shell and the drug in polydopamine shell, the utility model oral ulcer patch, due to pH response microsphere and ROS response microsphere have to pH response polyacrylic acid shell and to ROS response polydopamine shell, can realize self-regulation release rate according to the pH and ROS change in oral cavity caused by ulcer severity.
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