Sample addition device for in-vitro diagnostic analyzers

Abstract

This utility model discloses a sample dispensing device for an in vitro diagnostic analyzer, including a connecting base plate, an arc-shaped plate, and a cooling plate. A hollow plate is disposed above the connecting base plate, and a horizontal drive block is slidably connected inside the hollow plate. A linkage plate is fixedly connected to the front side of the horizontal drive block, and a pointed pipette is fixedly connected to the bottom of the linkage plate. An air bladder is fixedly connected to the top of the pointed pipette. Two arc-shaped plates are disposed outside the pointed pipette, and the top of the arc-shaped plates is fixedly connected to the bottom of the linkage plate. A cooling plate is fixedly connected to the side of the arc-shaped plates away from the pointed pipette. In this utility model, while the sample is drawn in through the pointed pipette, the cooling plate is activated and provides cooling. This cooling is transferred to the contacting cooling plate, then to the connected arc-shaped plate, and finally conducted by the arc-shaped plate to the pointed pipette. This cooling process can prevent excessive cooling and effectively avoid sample inactivation, denaturation, or degradation due to high temperature, thus achieving the function of heat preservation for the sample in the pipette.

Description

Technical Field

[0001] This utility model relates to the field of in vitro diagnostic sample loading technology, and in particular to a sample loading device for an in vitro diagnostic analyzer. Background Technology

[0002] In vitro diagnostics (IVD) refers to products and services that obtain clinical diagnostic information by testing human samples (blood, body fluids, tissues, etc.) outside the human body, thereby determining diseases or bodily functions. With the continuous advancement of technology, people's demand for reagent analysis is increasing. In vitro diagnostic analyzers help us understand the elements or substances contained in samples. When analyzing reagents, a sample addition device is needed to add the sample to the in vitro diagnostic analyzer.

[0003] Common in vitro diagnostic analyzer sample loading devices can only add samples into the analyzer, but lack the function of keeping the samples warm. Considering the biological characteristics of human samples, they must be kept in a low-temperature environment during processing and storage. If the sample is exposed to a high ambient temperature during the loading stage, the sample may become inactive, denatured, or degraded, which will directly affect the accuracy of subsequent test data and ultimately lead to deviations in the diagnostic conclusions.

[0004] Therefore, in view of the lack of sample insulation function, and considering that human sample processing requires a continuous low-temperature environment, high-temperature sample addition may lead to sample inactivation, denaturation or degradation, affecting detection accuracy and causing diagnostic bias, an in vitro diagnostic analyzer sample addition device can be designed. Utility Model Content

[0005] To overcome the lack of sample insulation, and considering that human sample processing requires a continuous low-temperature environment, high-temperature sample loading may lead to sample inactivation, denaturation, or degradation, affecting detection accuracy and causing diagnostic bias.

[0006] The technical solution of this utility model is as follows: an in vitro diagnostic analyzer sample dispensing device, including a connecting base plate; it also includes an arc-shaped plate and a cooling plate. A hollow plate is provided above the connecting base plate, and a horizontal driving block is slidably connected inside the hollow plate. A linkage plate is fixedly connected to the front side of the horizontal driving block. A pointed pipette is fixedly connected to the bottom of the linkage plate, and an air bladder is fixedly connected to the top of the pointed pipette. Two arc-shaped plates are provided on the outside of the pointed pipette, and the top of the arc-shaped plates is fixedly connected to the bottom of the linkage plate. A cooling plate is fixedly connected to the side of the arc-shaped plates away from the pointed pipette, and a cooling plate is fixedly connected to the end of the cooling plate away from the arc-shaped plates. A lifting mechanism is provided on the connecting base plate to control the lifting movement of the pointed pipette. A control mechanism is provided on the hollow plate to control the horizontal movement of the pointed pipette and the aspiration and release of the sample.

[0007] Preferably, while the sample is drawn into the pipette through the tip pipette, the cooling plate starts to provide cooling. The cooling on the cooling plate is transferred to the cooling transfer plate in contact with it. Then, the cooling transfer plate transfers the received cooling to the arc plate connected to it. Finally, the arc plate conducts the cooling to the tip pipette. Through this series of cooling transfer processes, not only can the excessive transfer of cooling be reduced, but the inactivation, denaturation or degradation of the sample due to excessive temperature can also be effectively prevented, thus achieving the function of heat preservation for the sample inside the tip pipette.

[0008] Preferably, the lifting mechanism includes a driving component and a driven component, wherein the driving component is used to control the lifting movement of the hollow plate, and the driven component is used to maintain the balance of the hollow plate.

[0009] Preferably, the driven component includes a left side frame fixedly connected to the left side of the connecting base plate, a slide rod fixed inside the left side frame, and a left lifting block slidably connected to the outside of the slide rod, with the left end of the hollow plate fixedly connected to the left lifting block.

[0010] Preferably, the drive assembly includes a right side frame fixedly connected to the right side of the connecting base plate, a first motor fixedly connected to the top of the right side frame, a first lead screw fixedly connected to the output end of the first motor, and a right lifting block threadedly connected to the outside of the first lead screw. The right end of the hollow plate is fixedly connected to the right lifting block, and the first motor is used to control the rotational movement of the first lead screw.

[0011] Preferably, the control mechanism includes a horizontal movement component and a clamping component. The horizontal movement component is used to control the horizontal movement of the pipette tip, and the clamping component is used to aspirate and release the sample.

[0012] Preferably, the horizontal moving assembly includes a mounting plate fixedly connected to the inside of the hollow plate, a second motor fixedly connected to the right side of the mounting plate, a second lead screw fixedly connected to the output end of the second motor, a horizontal drive block threadedly connected to the second lead screw, and the second motor being used to control the rotational movement of the second lead screw.

[0013] Preferably, the clamping bag assembly includes a fixed clamping plate fixedly connected to the top of the linkage plate, a limiting plate fixedly connected to the top of the linkage plate, a cylinder fixedly connected to the right side of the limiting plate, and a movable clamping plate fixedly connected to the output end of the cylinder. The cylinder is used to control the horizontal movement of the movable clamping plate.

[0014] The beneficial effects of this utility model are: The core advantage of this structure lies in its hierarchical, progressive cold transfer path, composed of a cooling plate, a heat transfer plate, and an arc-shaped plate. This achieves efficient, precise, and gradient-controllable cold transfer, significantly improving cooling efficiency and preventing excessive diffusion of cold to non-target areas and resource waste. More importantly, it ensures that the sample inside the pipette can quickly reach and maintain a safe temperature below the ambient temperature, effectively isolating external heat intrusion. This minimizes the risk of irreversible inactivation, structural denaturation, loss of enzyme activity, or chemical degradation caused by temperature fluctuations or excessively high temperatures, fundamentally guaranteeing the biological activity, integrity, and reliability of subsequent experimental results. Attached Figure Description

[0015] Figure 1 The diagram shown is a schematic representation of the overall structure of this utility model. Figure 2 The diagram shown is a schematic of the lifting mechanism of this utility model; Figure 3 The diagram shown is a schematic representation of the hollow plate structure of this utility model. Figure 4 The diagram shown is a schematic representation of the horizontal moving component of this utility model. Figure 5 The diagram shown is a schematic representation of the structure of the thermal insulation component of this utility model. Figure 6 This utility model is shown. Figure 4 Enlarged view of point A in the middle.

[0016] Explanation of reference numerals in the attached drawings: 1. Connecting base plate; 11. Hollow plate; 12. Horizontal drive block; 13. Linkage plate; 14. Pointed suction tube; 15. Airbag; 16. Arc plate; 17. Cooling plate; 18. Refrigeration plate; 211. Left side frame; 212. Sliding rod; 213. Left lifting block; 221. Right side frame; 222. First motor; 223. First lead screw; 224. Right lifting block; 311. Mounting plate; 312. Second motor; 313. Second lead screw; 321. Fixed clamping plate; 322. Limiting plate; 323. Cylinder; 324. Movable clamping plate. Detailed Implementation

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0018] Please see Figures 1-6This utility model provides an embodiment of an in vitro diagnostic analyzer sample dispensing device, including a connecting base plate 1; it also includes an arc-shaped plate 16 and a cooling plate 18. A hollow plate 11 is disposed above the connecting base plate 1, and a horizontal driving block 12 is slidably connected inside the hollow plate 11. A linkage plate 13 is fixedly connected to the front side of the horizontal driving block 12. A pointed pipette 14 is fixedly connected to the bottom of the linkage plate 13, and an airbag 15 is fixedly connected to the top of the pointed pipette 14. Two arc-shaped plates 16 are disposed on the outer side of the pointed pipette 14, and the top of the arc-shaped plates 16 is fixedly connected to the bottom of the linkage plate 13. A cooling plate 17 is fixedly connected to the side of the arc-shaped plates 16 away from the pointed pipette 14. The cooling plate 17 is located away from the arc-shaped plates 16. A cooling plate 18 is fixedly connected to one end, and a lifting mechanism is provided on the connecting base plate 1. The lifting mechanism is used to control the lifting and lowering movement of the pointed pipette 14. A control mechanism is provided on the hollow plate 11. The control mechanism is used to control the horizontal movement of the pointed pipette 14 and the suction and release of the sample. The sample is sucked into the pointed pipette 14, and at the same time, it is cooled by the cooling plate 18. The cold energy on the cooling plate 18 is transferred to the cold transfer plate 17, and then transferred to the arc plate 16 through the cold transfer plate 17. Finally, the cold energy is transferred to the pointed pipette 14 through the arc plate 16, thereby keeping the sample in the pointed pipette 14 warm and preventing the sample from becoming inactive, denatured or degraded due to excessive temperature. This achieves the function of keeping the sample warm.

[0019] Please see Figures 2-6 In this embodiment, the lifting mechanism includes a driving component and a driven component. The driving component controls the lifting movement of the hollow plate 11, and the driven component maintains the balance of the hollow plate 11. The driving component and the driven component combine to form a complete lifting mechanism, which cooperate to control the lifting movement of the pointed straw 14. The driven component includes a left side frame 211 fixedly connected to the left side of the connecting base plate 1, a slide rod 212 fixed inside the left side frame 211, and a left lifting block 213 slidably connected to the outside of the slide rod 212. The left end of the hollow plate 11 is fixedly connected to the left lifting block 213. The hollow plate 11 drives the left lifting block 213 to slide up and down along the slide rod 212 inside the left side frame 211. The driving component includes... The right side frame 221 is fixedly connected to the right side of the connecting base plate 1. The first motor 222 is fixedly connected to the top of the right side frame 221. The first lead screw 223 is fixedly connected to the output end of the first motor 222. The right lifting block 224 is threadedly connected to the outside of the first lead screw 223. The right end of the hollow plate 11 is fixedly connected to the right lifting block 224. The first motor 222 is used to control the rotation of the first lead screw 223. The first motor 222 drives the first lead screw 223 to rotate. The first lead screw 223 drives the right lifting block 224 to move up and down inside the right side frame 221. The right lifting block 224 drives the hollow plate 11 to move up and down. The hollow plate 11 drives the pointed straw 14 to move up and down through the horizontal drive block 12.

[0020] Please see Figures 1-6 In this embodiment, the control mechanism includes a horizontal movement component and a clamping component. The horizontal movement component controls the horizontal movement of the pipette tip 14, and the clamping component is used for sample suction and release. The horizontal movement component and the clamping component together form a complete control mechanism, which cooperate to control the horizontal movement of the pipette tip 14 and the suction and release of the sample. The horizontal movement component includes a mounting plate 311 fixedly connected to the inside of the hollow plate 11, a second motor 312 fixedly connected to the right side of the mounting plate 311, and a second lead screw 313 fixedly connected to the output end of the second motor 312. The horizontal drive block 12 is threadedly connected to the second lead screw 313. The second motor 312 controls the rotational movement of the second lead screw 313. The second motor 312 drives the second lead screw 313 to rotate, and the second lead screw 313 drives the horizontal movement of the pipette tip 14. The drive block 12 moves left and right, and the horizontal drive block 12 drives the tip pipette 14 to move left and right. The clamping bag assembly includes a fixed clamping plate 321 fixedly connected to the top of the linkage plate 13, a limiting plate 322 fixedly connected to the top of the linkage plate 13, a cylinder 323 fixedly connected to the right side of the limiting plate 322, and a movable clamping plate 324 fixedly connected to the output end of the cylinder 323. The cylinder 323 is used to control the horizontal movement of the movable clamping plate 324. After the tip pipette 14 reaches the designated position for sucking up the sample, the cylinder 323 drives the movable clamping plate 324 to move away from the fixed clamping plate 321 until the clamping state of the airbag 15 is released. At this time, the airbag 15 will unfold. During the unfolding process, a negative pressure will be formed inside the tip pipette 14, and the sample will be sucked into it by the negative pressure inside the tip pipette 14.

[0021] During operation, the second motor 312 first drives the second lead screw 313 to rotate, which in turn drives the horizontal drive block 12 to move left and right. The horizontal drive block 12 then drives the pointed pipette 14 to move left and right until the pointed pipette 14 is precisely positioned above the sample container. At this time, the airbag 15 is held by the fixed clamping plate 321 and the movable clamping plate 324. Next, the first motor 222 starts and drives the first lead screw 223 to rotate. The first lead screw 223 drives the right lifting block 224 to move downward inside the right frame 221. The right lifting block 224 drives the hollow plate 11 to move downward. The hollow plate 11 then drives the pointed pipette 14 to move downward through the horizontal drive block 12. At the same time, the hollow plate 11 also drives the left lifting block 213 to slide downward along the slide rod 212 inside the left frame 211 until the pointed pipette 14 reaches the sample container. The sample is drawn from a designated location. Then, cylinder 323 actuates, pushing movable clamp 324 away from fixed clamp 321, releasing the clamp on airbag 15. Airbag 15 then unfolds, creating a negative pressure inside the pipette 14 during its unfolding. This negative pressure draws the sample into the pipette 14. Simultaneously, as the sample is drawn into the pipette 14, cooling plate 18 begins to provide cooling. The cooling energy on cooling plate 18 is transferred to the cooling plate 17 in direct contact with it. The cooling plate 17 then transfers the received cooling energy to the arc plate 16 connected to it. Finally, the arc plate 16 conducts the cooling energy to the pipette 14. Through this series of cooling energy transfer processes, not only is excessive cooling energy transfer reduced, but the inactivation, denaturation, or degradation of the sample can also be effectively prevented.

[0022] Through the above steps, while the sample is drawn in through the pipette 14, the cooling plate 18 is activated and provides cooling. This cooling is transferred to the contacting cooling plate 17, then to the connected arc plate 16, and finally conducted to the pipette 14 by the arc plate 16. This cooling process can prevent excessive cooling and effectively avoid sample inactivation, denaturation, or degradation due to high temperature, thus achieving the function of keeping the sample in the pipette warm. This solves the problem that common in vitro diagnostic analyzer sample loading devices can only add samples to the in vitro diagnostic analyzer but lack the function of keeping the samples warm. High temperature sample loading may lead to sample inactivation, denaturation, or degradation, affecting the diagnostic results.

Claims

1. An in vitro diagnostic analyzer sample loading device, comprising a connecting base plate (1); characterized in that: It also includes an arc-shaped plate (16) and a cooling plate (18). A hollow plate (11) is provided above the connecting base plate (1). A horizontal drive block (12) is slidably connected inside the hollow plate (11). A linkage plate (13) is fixedly connected to the front side of the horizontal drive block (12). A pointed straw (14) is fixedly connected to the bottom of the linkage plate (13). An airbag (15) is fixedly connected to the top of the pointed straw (14). Two arc-shaped plates (16) are provided on the outside of the pointed straw (14). The top of the tube is fixedly connected to the bottom of the linkage plate (13). A cooling plate (17) is fixedly connected to the side of the arc plate (16) away from the tip pipette (14). A cooling plate (18) is fixedly connected to the end of the cooling plate (17) away from the arc plate (16). A lifting mechanism is provided on the connecting base plate (1). The lifting mechanism is used to control the lifting movement of the tip pipette (14). A control mechanism is provided on the hollow plate (11). The control mechanism is used to control the horizontal movement of the tip pipette (14) and the suction and release of the sample.

2. The sample dispensing device for an in vitro diagnostic analyzer according to claim 1, characterized in that: The lifting mechanism includes a drive component and a driven component. The drive component is used to control the lifting and lowering movement of the hollow plate (11), and the driven component is used to maintain the balance of the hollow plate (11).

3. The sample dispensing device for an in vitro diagnostic analyzer according to claim 2, characterized in that: The driven component includes a left frame (211) fixedly connected to the left side of the connecting base plate (1), a slide rod (212) fixed inside the left frame (211), and a left lifting block (213) slidably connected to the outside of the slide rod (212). The left end of the hollow plate (11) is fixedly connected to the left lifting block (213).

4. The sample dispensing device for an in vitro diagnostic analyzer according to claim 3, characterized in that: The drive assembly includes a right side frame (221) fixedly connected to the right side of the connecting base plate (1), a first motor (222) fixedly connected to the top of the right side frame (221), a first lead screw (223) fixedly connected to the output end of the first motor (222), and a right lifting block (224) threadedly connected to the outside of the first lead screw (223). The right end of the hollow plate (11) is fixedly connected to the right lifting block (224). The first motor (222) is used to control the rotation of the first lead screw (223).

5. The sample dispensing device for an in vitro diagnostic analyzer according to claim 1, characterized in that: The control mechanism includes a horizontal movement component and a clamping component. The horizontal movement component is used to control the horizontal movement of the tip pipette (14), and the clamping component is used to aspirate and release the sample.

6. The sample dispensing device for an in vitro diagnostic analyzer according to claim 5, characterized in that: The horizontal moving assembly includes a mounting plate (311) fixedly connected to the inside of the hollow plate (11), a second motor (312) fixedly connected to the right side of the mounting plate (311), and a second lead screw (313) fixedly connected to the output end of the second motor (312). The horizontal drive block (12) is threadedly connected to the second lead screw (313). The second motor (312) is used to control the rotational movement of the second lead screw (313).

7. The sample dispensing device for an in vitro diagnostic analyzer according to claim 6, characterized in that: The clamping bag assembly includes a fixed clamping plate (321) fixedly connected to the top of the linkage plate (13), a limiting plate (322) fixedly connected to the top of the linkage plate (13), a cylinder (323) fixedly connected to the right side of the limiting plate (322), and a movable clamping plate (324) fixedly connected to the output end of the cylinder (323). The cylinder (323) is used to control the horizontal movement of the movable clamping plate (324).

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