Innocent treatment system of distillation residue of metformin hydrochloride

Abstract

The utility model relates to a chemical system technical field especially relates to a kind of innocuous treatment system of metformin hydrochloride distillation residue. The method of ultrasonic digestion device and anaerobic reactor combination is used, pretreatment is carried out to distillation residue first, improves organic matter degradation rate, improves processing efficiency, then carries out anaerobic biochemical reaction to the pollutant after pretreatment, substantially digests the chemical oxygen demand in high concentration organic waste, makes pollutant reduction, reduces the final disposal cost of dangerous waste, and removal of harmful substances can be realized without good itch treatment. Meanwhile, the oxygen treatment step is saved, the technological process is simplified, the treatment time of distillation waste residue is shortened, the oxygen treatment equipment is reduced, and it is beneficial to cost saving.

Description

Technical Field

[0001] This utility model relates to the field of chemical system technology, and in particular to a harmless treatment system for distillation residue of metformin hydrochloride. Background Technology

[0002] Metformin is a white crystalline or crystalline powder, mainly used for the treatment of type 2 diabetes that is unresponsive to diet control and physical exercise alone, especially in obese type 2 diabetes patients. When used in combination with insulin, it can reduce the amount of insulin needed and prevent hypoglycemia.

[0003] The industrial production method of metformin hydrochloride requires solvent distillation recovery after the addition reaction using solvents. During the recovery of DMF, toluene, and methanol solvents, a large amount of distillation residue is generated, mainly composed of toxic and harmful organic waste. Due to the complex composition of the distillation residue, it can only be treated as solid waste. Therefore, considering clean production, resource recycling, and environmental protection, there is an urgent need for a green process to recover distillation residue and recycle the products and byproducts.

[0004] In the prior art, Chinese invention patent application number 202310918388.2 discloses a method for harmlessly treating the distillation residue of metformin hydrochloride. First, the distillation residue of metformin hydrochloride is hydrolyzed and acidified. After acidification, solid-liquid separation is performed to obtain solution A and acidified residue. Then, the acidified residue is anaerobically treated, and after anaerobic treatment, solid-liquid separation is performed to obtain solution B and anaerobic residue. Next, the anaerobic residue is aerobically treated, and after aerobic treatment, solid-liquid separation is performed to obtain solution C and harmless residue. The harmless residue is then treated. Finally, solutions A, B, and C are mixed, concentrated, and pyrolyzed to obtain fertilizer and mixture.

[0005] The core of the above treatment is hydrolysis acidification-anaerobic treatment-aerobic treatment, which involves many processes and takes a long time. Summary of the Invention

[0006] Based on this, this application provides a harmless treatment system for distillation residue of metformin hydrochloride to solve the technical problems of multiple process steps and long processing time in the prior art.

[0007] The technical solution to the above-mentioned technical problems in this application is as follows:

[0008] A hazardous substance removal system includes an ultrasonic digestion device and an anaerobic reactor; the outlet of the ultrasonic digestion device is connected to the inlet of the anaerobic reactor, the anaerobic reactor is equipped with a heating device, and the top of the anaerobic reactor is also equipped with a waste gas discharge pipe.

[0009] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the other end of the exhaust pipe is connected to an exhaust gas treatment device.

[0010] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the anaerobic reactor is further equipped with a microbial inlet pipe.

[0011] Preferably, the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride further includes an equalization tank, which is equipped with a distillation residue feed pipe and a wastewater feed pipe. The outlet of the equalization tank is connected to the inlet of the ultrasonic digestion device through a pollutant feed pipe, and a conveying pump is installed on the pollutant feed pipe.

[0012] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the outlet of the anaerobic reactor is connected to a transfer tank, the outlet of the transfer tank is connected to a separator, the liquid phase outlet of the separator is connected to a wastewater treatment system, and the solid phase outlet of the separator is connected to a sludge dewatering system.

[0013] Preferably, the above-mentioned harmless treatment system for metformin hydrochloride distillation residue further includes a sludge dewatering system, which includes a buffer tank, a thickening tank, and a sludge dewatering machine. The inlet of the buffer tank is connected to the solid phase outlet of the separator, the outlet of the buffer tank is connected to the inlet of the thickening tank, and the outlet of the thickening tank is connected to the inlet of the sludge dewatering machine.

[0014] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the buffer tank is equipped with a sludge return pipe, and the other end of the sludge return pipe is connected to the inlet of the anaerobic reactor.

[0015] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the liquid phase outlet of the sludge dewatering machine is connected to the wastewater treatment system.

[0016] Preferably, in the above-mentioned harmless treatment system for distillation residue of metformin hydrochloride, the solid phase outlet of the sludge dewatering machine is equipped with a sludge cake collection pipe.

[0017] Preferably, in the above-mentioned harmless treatment system for metformin hydrochloride distillation residue, at least two sets of the harmful substance removal system are arranged in parallel within the harmless treatment system.

[0018] Compared with the prior art, the present invention has at least the following advantages:

[0019] The metformin hydrochloride distillation residue harmless treatment system disclosed in this application mainly adopts a combination of ultrasonic digestion device and anaerobic reactor. The distillation residue is first pretreated to improve the organic matter degradation rate and treatment efficiency. Then, the pretreated distillation residue undergoes an anaerobic biochemical reaction to significantly reduce the chemical oxygen demand (COD) in high-concentration organic waste, thereby reducing the volume of distillation residue and the final disposal costs of hazardous waste. Compared with existing technologies, this application eliminates the aerobic treatment step, simplifies the process flow, shortens the treatment time of distillation waste residue, and reduces the need for aerobic treatment equipment, thus saving costs. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of a system for the harmless treatment of distillation residue from metformin hydrochloride.

[0021] In the diagram: Hazardous substance removal system 10, ultrasonic digestion device 100, pollutant feed pipe 110, transfer pump 120, anaerobic reactor 200, heating device 210, steam feed pipe 211, exhaust gas discharge pipe 220, microbial inoculum feed pipe 230, exhaust gas treatment device 300, equalization tank 400, distillation residue feed pipe 410, wastewater feed pipe 420, separator 500, sewage treatment system 600, sludge dewatering system 700, buffer tank 710, sludge return pipe 712, thickening tank 720, sludge dewatering machine 730, sludge cake collection pipe 731, transfer tank 800. Detailed Implementation

[0022] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings. Preferred embodiments of this application are shown in the drawings. However, this application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure of this application.

[0023] It should be noted that when an element is referred to as being "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," "top," "bottom," "end," "top," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to be limiting of this application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0025] Please see Figure 1 In one specific embodiment of this application, a harmless treatment system for metformin hydrochloride distillation residue includes: a hazardous substance removal system 10, wherein the hazardous substance removal system 10 includes an ultrasonic digestion device 100 and an anaerobic reactor 200; the outlet of the ultrasonic digestion device 100 is connected to the inlet of the anaerobic reactor 200, the anaerobic reactor 200 is provided with a heating device 210, and the top of the anaerobic reactor 200 is also provided with a waste gas discharge pipe 220.

[0026] The distillation residues in this application mainly originate from the rectification residues generated during the recovery of DMF, toluene, and methanol solvents in the production of metformin hydrochloride. Their main components are toxic and hazardous organic wastes. They also include distillation and reaction residues generated during the production of chemically synthesized pharmaceutical raw materials (HW02 Pharmaceutical Waste 271-001-02). These distillation residues are first processed by an ultrasonic digestion device 100. Utilizing ultrasonic cavitation, the structure of long-chain, ring-chain, and other recalcitrant substances in the residues is altered, resulting in some disruption of cell walls, increasing the anaerobic organic matter degradation rate, improving biodegradability, and maximizing the degradation of organic pollutants.

[0027] The residue pretreated by the ultrasonic digestion device 100 is transported to the anaerobic reactor 200 for anaerobic biochemical treatment, ensuring thorough mixing of the anaerobic sludge bacteria and the residue, thereby achieving efficient mass transfer and energy exchange. To ensure a more complete and effective anaerobic reaction, this application preferentially uses a fully mixed anaerobic reactor 200. Furthermore, to ensure uniform mixing of the sludge bacteria and the residue for excellent reaction results, the anaerobic reactor 200 is equipped with a stirrer. Since mesophilic anaerobic processes are typically employed, the anaerobic reactor 200 is also equipped with a heating device 210. The heating device 210 can be a stainless steel coil arranged inside the reactor, with hot steam introduced into the coil to heat the reactor interior; or it can be a heating jacket surrounding the reactor tank, with hot steam introduced into the jacket for heating. The heating device 210 can be selected as needed based on site conditions and is not limited to the above two forms. In this application, a heating jacket is preferred. The heating jacket is equipped with a steam feed pipe 211. During the reaction, steam is introduced through the steam feed pipe 211 to heat the reaction to the predetermined reaction temperature. The other end of the steam feed pipe 211 is connected to a boiler system.

[0028] The aforementioned hazardous waste removal system 10 employs a combination of an ultrasonic digestion device 100 and an anaerobic reactor 200. First, the distillation residue is pretreated to improve the organic matter degradation rate and treatment efficiency. Then, the pretreated pollutants undergo an anaerobic biochemical reaction, significantly reducing the chemical oxygen demand (COD) in high-concentration organic waste, thereby reducing pollutant volume and the final disposal costs of hazardous waste. This eliminates the need for aerobic treatment, simplifying the process, shortening the treatment time for distillation waste, and reducing the need for aerobic treatment equipment, thus saving costs.

[0029] As mentioned above, in the anaerobic biological treatment process, anaerobic sludge bacteria are needed to biochemically degrade the residue. Therefore, the anaerobic reactor 200 is also equipped with a bacterial feed pipe 230, which can add bacteria according to the on-site reaction conditions.

[0030] The waste gas generated during the anaerobic fermentation process mainly consists of CH4 and water vapor. This waste gas is discharged from the anaerobic reactor 200 through the waste gas discharge pipe 220. The other end of the waste gas discharge pipe 220 is connected to the waste gas treatment device 300, which mainly includes a water spray and an activated carbon adsorption device. The waste gas is treated to meet the standards before being discharged.

[0031] In another specific embodiment of this application, the harmless treatment system for distillation residue of metformin hydrochloride further includes an equalization tank 400, which is provided with a distillation residue feed pipe 410 and a wastewater feed pipe 420. The outlet of the equalization tank 400 is connected to the inlet of the ultrasonic digestion device 100 through a pollutant feed pipe 110, and a transfer pump 120 is provided on the pollutant feed pipe 110.

[0032] The distillation residue and wastewater generated during the metformin hydrochloride production process are sent to the equalization tank 400. The equalization tank 400 mixes the high-concentration distillation residue and the low-concentration wastewater to bring the pollutant concentration in the equalization tank 400 to a certain range (e.g., COD≦25000mg / L, TN≦2500mg / L and pH=6.5~8.2). Then, the wastewater is sent to the ultrasonic digestion device 100 for pretreatment using the transfer pump 120.

[0033] In a preferred embodiment, the outlet of the anaerobic reactor 200 is connected to a transfer tank 800, the outlet of the transfer tank 800 is connected to a separator 500, the liquid phase outlet of the separator 500 is connected to a wastewater treatment system 600, and the solid phase outlet of the separator 500 is connected to a sludge dewatering system 700. The transfer tank 800 mainly serves as a transfer and temporary storage unit, and material is always present in the transfer tank 800, thus enabling the entire system to operate continuously. After the anaerobic reaction, the material needs to undergo solid-liquid separation; therefore, the outlet of the transfer tank 800 is connected to the separator 500, the liquid phase outlet of the separator 500 is connected to the wastewater treatment system 600, and the solid phase outlet of the separator 500 is connected to the sludge dewatering system 700. After anaerobic reaction, the material is fed into separator 500 for solid-liquid separation. To achieve higher separation efficiency, a high-density separator can be used to separate sludge and water. The separated sludge is sent to sludge dewatering system 700 through the solid phase outlet of separator 500, and the separated wastewater is sent to wastewater treatment system 600 for treatment through the liquid phase outlet of separator 500.

[0034] Furthermore, the harmless treatment system for distillation residue of metformin hydrochloride of this application also includes a sludge dewatering system 700, which includes a buffer tank 710, a thickening tank 720, and a sludge dewatering machine 730. The inlet of the buffer tank 710 is connected to the solid phase outlet of the separator 500, the outlet of the buffer tank 710 is connected to the inlet of the thickening tank 720, and the outlet of the thickening tank 720 is connected to the inlet of the sludge dewatering machine 730. The sludge with a high water content separated from separator 500 is sent to buffer tank 710. In a preferred embodiment, buffer tank 710 is equipped with sludge return pipe 712, the other end of which is connected to the inlet of anaerobic reactor 200. Part of the sludge in buffer tank 710 is reused in anaerobic reactor 200 through sludge return pipe 712 for further biochemical treatment of pollutants. Due to the high sludge concentration and poor fluidity, a positive displacement pump, such as a screw pump, can be installed on sludge return pipe 712 to transport the sludge to the inlet of anaerobic reactor 200. Part of the sludge in buffer tank 710 is sent to thickener 720, where a polymeric flocculant is added to improve sludge dewatering efficiency and reduce sludge volume. Finally, the sludge in thickener 720 enters sludge dewatering machine 730 for dewatering. Furthermore, the liquid phase outlet of the sludge dewatering machine 730 is connected to the wastewater treatment system 600. Wastewater generated by the sludge dewatering machine 730 is sent to the wastewater treatment system 600 for treatment from the liquid phase outlet. The solid phase outlet of the sludge dewatering machine 730 is equipped with a sludge cake collection pipe 731, from which the dewatered sludge cake is collected.

[0035] The workflow of the metformin hydrochloride distillation residue harmless treatment system of this application is as follows: Distillation residue and wastewater generated during the production of metformin hydrochloride are sent to an equalization tank 400. The equalization tank 400 mixes high-concentration distillation residue and low-concentration wastewater to bring the pollutant concentration in the equalization tank 400 to a certain range. Then, a transfer pump 120 sends the mixture to an ultrasonic digestion device 100 for pretreatment. In the ultrasonic digestion device 100, the pretreated pollutants are more conducive to anaerobic biological treatment. The mixture is then sent to an anaerobic reactor 200 for anaerobic biological treatment. In the anaerobic reactor 200, a stirrer ensures thorough mixing of anaerobic sludge bacteria and residue. Simultaneously, steam is introduced through a steam feed pipe 211 to provide the necessary ambient temperature for anaerobic treatment. Waste gas generated during the anaerobic reaction is discharged from the anaerobic reactor 200 through a waste gas discharge pipe 220 and sent to a waste gas treatment device 300 for treatment before being discharged. After the anaerobic biochemical reaction is completed, the material is sent to a solid-liquid separator to separate the sludge and water. The separated sludge is sent to a buffer tank 710, and the wastewater is sent to the sewage treatment system 600 for treatment. The sludge with a high water content after separation by the separator 500 is discharged into the buffer tank 710. Part of the sludge in the buffer tank 710 is reused in the anaerobic reactor 200, and part of the sludge enters the thickening tank 720. After adding a polymer flocculant, the sludge is dewatered by a sludge dewatering machine 730. The dewatered sludge cake is then identified as hazardous waste. If it is general solid waste, it will be comprehensively utilized; if it is hazardous waste, it will be further treated. The wastewater generated by the sludge dewatering machine 730 is sent from the liquid phase outlet to the sewage treatment system 600 for treatment.

[0036] In a preferred embodiment, at least two sets of the hazardous substance removal system 10 are arranged in parallel within the harmless treatment system. The inlet of each hazardous substance removal system 10 is connected to the outlet of the equalization tank 400, and the outlet of each system is connected to the inlet of the transfer tank 800. That is, the hazardous substance removal systems 10 are connected in parallel, and the outlet of the ultrasonic digestion device 100 in each system is connected to the outlet of the equalization tank 400. Pollutants discharged from the equalization tank 400 can be simultaneously and graded and fed into each system. The outlet of the anaerobic reactor 200 in each system is connected to the inlet of the transfer tank 800. Each set of hazardous material removal system 10 operates independently, sending the anaerobic substances into the transfer tank 800. The transfer tank 800 mainly serves as a transfer and temporary storage tank. The operation of multiple sets of hazardous material removal systems 10 can ensure that there are always materials in the transfer tank 800, thus enabling the entire system to operate continuously.

[0037] The above-disclosed embodiments are merely preferred embodiments of the present utility model and should not be construed as limiting the scope of the present utility model. Those skilled in the art can understand that implementing all or part of the above-described embodiments and making equivalent changes in accordance with the claims of the present utility model are still within the scope of the utility model.

Claims

1. A harmless treatment system for distillation residue of metformin hydrochloride, characterized in that, include: A hazardous substance removal system includes an ultrasonic digestion device and an anaerobic reactor; the outlet of the ultrasonic digestion device is connected to the inlet of the anaerobic reactor, the anaerobic reactor is equipped with a heating device, and the top of the anaerobic reactor is also equipped with a waste gas discharge pipe.

2. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 1, characterized in that, The anaerobic reactor is also equipped with a microbial inlet pipe.

3. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 1, characterized in that, The other end of the exhaust pipe is connected to an exhaust gas treatment device.

4. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 1, characterized in that, It also includes an equalization tank, which is equipped with a distillation residue feed pipe and a wastewater feed pipe. The outlet of the equalization tank is connected to the inlet of the ultrasonic digestion device through a pollutant feed pipe, and a conveying pump is installed on the pollutant feed pipe.

5. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 1, characterized in that, The outlet of the anaerobic reactor is connected to a transfer tank, the outlet of the transfer tank is connected to a separator, the liquid phase outlet of the separator is connected to a wastewater treatment system, and the solid phase outlet of the separator is connected to a sludge dewatering system.

6. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 5, characterized in that, The sludge dewatering system includes a buffer tank, a thickening tank, and a sludge dewatering machine. The inlet of the buffer tank is connected to the solid phase outlet of the separator, the outlet of the buffer tank is connected to the inlet of the thickening tank, and the outlet of the thickening tank is connected to the inlet of the sludge dewatering machine.

7. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 6, characterized in that, The buffer tank is equipped with a sludge return pipe, and the other end of the sludge return pipe is connected to the inlet of the anaerobic reactor.

8. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 6, characterized in that, The liquid phase outlet of the sludge dewatering machine is connected to the wastewater treatment system.

9. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 6, characterized in that, The sludge dewatering machine is equipped with a sludge cake collection pipe at its solid phase outlet.

10. The harmless treatment system for metformin hydrochloride distillation residue as described in claim 1, characterized in that, The pest removal system comprises at least two sets, which are arranged in parallel within the harmless treatment system.

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