Holding device for a component of an analysis device

Abstract

A holding device (110) for a component (30) associated with an analysis device (10) is described, wherein the holding device (110) comprises: i) a coupling device (111) for coupling the component (30) such that the coupling device (111) at least partially encloses the component (30) to be coupled; and ii) a spacer device (115) for spacing the coupling device (111) from the coupled component (30).

Description

AREA OF INVENTION

[0001] The present invention relates to a holding device for a component associated with an analysis device, wherein the holding device comprises: a coupling device for coupling the component such that the coupling device at least partially encloses the component to be coupled; and a spacer device for spacing the coupling device from the coupled component. The invention further relates to a holding system, the analysis device, and a method. TECHNICAL BACKGROUND

[0002] Analytical devices include, for example, chromatography devices, in particular sample separation devices, for the analysis of a sample, in particular a fluidic sample, e.g. for carrying out a chromatographic separation of the sample.

[0003] In an HPLC (high-performance liquid chromatography) chromatography instrument, a liquid (mobile phase) is moved through a stationary phase (e.g., in a chromatographic column) at a very precisely controlled flow rate (e.g., in the range of microliters to milliliters per minute) and at high pressure (typically 20 to 1000 bar and beyond, currently up to 2000 bar), at which the compressibility of the liquid may be noticeable, in order to separate individual fractions of a sample liquid introduced into the mobile phase. After passing through the stationary phase, the separated fractions of the fluidic sample are detected in a detector. Such an HPLC system is known, for example, from EP 0,309,596 B1 of the same applicant, Agilent Technologies, Inc.

[0004] The actual sample separation of the fluidic sample (in the mobile phase) takes place in a sample separation apparatus containing the stationary phase. Such a sample separation apparatus is usually implemented as a chromatographic column (a component associated with the analytical instrument) located in a temperature-controlled chamber or column oven. By placing the sample separation apparatus inside the temperature-controlled chamber, its temperature can be regulated; heat exchangers are typically provided for this purpose. Conventionally, the sample separation apparatus is secured within the temperature-controlled chamber, for example, with rubber clips.

[0005] Components associated with an analytical instrument, such as the separation column described above, are often marked for identification purposes. The unique identification of separation columns can be crucial in HPLC, for example, to ensure reliable traceability and identification of the columns used. A common method for this is the use of RFID (Radio Frequency Identification) tags. These small electronic components are attached to the column and enable contactless transmission of information such as serial number, product type, or usage data.

[0006] Currently, such an RFID tag is attached to the separation column using a loop. When the separation column is placed in a column oven of the analysis device, the RFID tag attached to the loop can be hung out of the oven and thus read even during operation. However, this solution with a loop can be impractical to handle and can also disrupt the operation of the column oven. Furthermore, the RFID tag can be easily removed, making traceability more difficult and reducing reliability. RFID solutions also require certification, which is time-consuming and generates additional costs. SUMMARY OF THE INVENTION

[0007] There may be a need to handle a component associated with an analysis device in an efficient and reliable manner.

[0008] The following describes a holding device, a holding system, an analysis device, a method, and a use.

[0009] According to a first aspect of the invention, a holding device (for holding a component) is described for a component (e.g. a separation column) associated with a (fluidic) analysis device (for analyzing a fluidic sample in a fluidic flow path), wherein the holding device comprises: i) a coupling device for coupling the component in such a way that the coupling device at least partially encloses the component to be coupled (in particular perpendicular to the main extension direction of the component) (e.g. two coupling elements which enclose or clamp the component in a connected / closed state), and ii) a spacer device (e.g. spacer elements such as finger elements) for spacing the coupling device from the coupled component (e.g. so that thermal coupling of the holding device with the flow path is reduced during operation of the fluidic analysis device).

[0010] According to a second aspect of the invention, a holding system is described for a component associated with an analysis device, wherein the holding system comprises: i) a holding device (in particular as described above) comprising a coupling device for coupling the component; and ii) a base device designed to couple the holding device to the analysis device (in particular via a base coupling connection); iii) wherein the holding device and the base device are coupled or can be coupled (e.g. via a magnetic connection), and iv) wherein the coupling includes an electrical coupling (power supply) and / or a magnetic coupling (stable and flexible) and / or a communicative coupling (data transmission).

[0011] According to a third aspect of the invention, an analysis device is described which includes the holding device or holding system (as described above).

[0012] According to a fourth aspect of the invention, a method for handling a component associated with an analysis device is described, wherein the method comprises: i) coupling the component with a holding device such that a coupling device of the holding device at least partially encloses the coupled component, and ii) spacing the coupling device from the coupled component, in particular by means of an air gap.

[0013] According to a fifth aspect of the invention, a method is described comprising: i) coupling a component associated with an analysis device to a holding device, and ii) connecting the holding device to a base device via at least one of the following: an electrical coupling, a communicative coupling, a magnetic coupling, and in particular coupling the holding device and / or the base device to the analysis device.

[0014] According to a sixth aspect of the invention, the use of a holding device or holding system (as described above) is described to couple a component in a temperature control chamber (thermostat) of an analysis device and to read out information relating to the coupled component via a wired connection.

[0015] Within the scope of this document, the term "holding device" refers in particular to a technical device designed to hold a component associated with an analytical device (e.g., a chromatographic column). In one embodiment, the holding device is configured to couple with a base device and / or the analytical device (particularly via the base device). The coupling can be at least one of the following: mechanical, electrical, or communicative, so that, in addition to a reliable connection, additional functions can be provided if necessary. The holding device includes a coupling device for connecting or holding the component. In one embodiment, the holding device includes a spacer device by means of which the contact between the coupling device and the component is minimized (particularly for thermal insulation).In one embodiment, the holding device has a first connecting device for connecting to the base device.

[0016] Within the scope of this document, the term "base device" refers in particular to a technical device (component, module, adapter) that serves as an interface between the holding device (with the component attached to it, e.g., a separation column) and the analytical device (e.g., an HPLC instrument). In one embodiment, the base device has a second connection device for connecting / coupling to the first connection device of the holding device. The second connection device can have a defined location or a mounting for a connection on which the holding device can be securely and correctly positioned. Preferably, the connection is at least one of the following: magnetic, electrical, or communicative (data transmission, one-way or two-way). In another embodiment, the base device can also provide a connection between (the information or...The communication device connects the holding device and the electronics of the analysis device (this can be done, for example, via pogo pins, plug connectors, or other connecting elements). The base device can act as an adapter between different elements and the analysis device by integrating various interfaces (mechanical, electrical, communicative).

[0017] Within the scope of this document, the term "holding system" is understood in particular to mean an arrangement of a holding device and a base device, in particular wherein the holding device (by means of a first connecting device) and the base device (by means of a second connecting device) are coupled to each other.

[0018] Within the scope of this document, the term "coupling device" refers in particular to a part / section of the holding device that is designed to couple (especially enclose) the component. For example, the coupling device may have two coupling elements that fold together and effectively clamp the component between them. In one embodiment, however, there is (essentially) no direct physical contact between the coupling device and the component because they are separated by a spacer device. The spacer device can be understood as an independent structure, even if it is connected to the coupling device (especially if it is formed as a single piece).

[0019] Within the scope of this document, the term "spacer device" refers specifically to an element or structure designed to establish and, in particular, maintain a defined distance between the coupling device and the coupled component. The spacer device can ensure that the coupling device and the component do not lie directly on top of each other, but are separated by an air gap and / or multiple spacer elements (e.g., finger elements). This distance can reduce or prevent heat transfer between the connected parts. The spacer device can be designed so that physical or thermal contact occurs only at specific, carefully selected points (e.g., via individual finger elements). This minimizes, for example, mechanical stresses and unwanted heat conduction. The spacer device can, for example,several separate spacer elements, such as elastic finger elements, webs or lamellae, which protrude (essentially perpendicularly) from the coupling device and only touch the component at points.

[0020] Within the context of this document, the term "communication" refers specifically to the targeted exchange of information between the participating system components, which can occur both wired and wirelessly. Communication (via communicative coupling) can, for example, enable the unambiguous identification of the component used, the retrieval of operational or sensor data, automatic documentation, and the control of processes within the analysis system.

[0021] Within the context of this document, the term "fluidic sample" refers in particular to a medium, and further specifically to a liquid, which contains the matter to be analyzed (for example, a biological sample), such as a protein solution, a pharmaceutical sample, etc.

[0022] Within the context of this document, the term "mobile phase" refers specifically to a fluid, and more specifically a liquid, that serves as a carrier medium for transporting the fluidic sample between a fluid drive and a sample separation device. However, the mobile phase can also be used in a fluid conveying device to influence the fluidic sample. For example, the mobile phase can be a solvent (e.g., organic and / or inorganic) or a solvent composition (e.g., water and ethanol).

[0023] Within the scope of this document, the term "analytical device" may, in particular, refer to a device capable of and configured to analyze a fluidic sample, especially to separate it, and further, especially to separate it into different fractions. For example, such sample separation may be carried out by means of chromatography or electrophoresis. Preferably, the analytical device may be a liquid chromatography sample separation device. The analytical device is, in particular, configured to perform an analytical method or a (possibly planned or programmed) sequence of analytical methods or procedures. Furthermore, the term "analytical method" may also be used to refer to a sequence, program, or execution list of analytical methods, procedures, or instructions, including adaptation, preparation, equilibration, and intermediate steps, etc.

[0024] According to an exemplary embodiment, the invention can be based on the idea that a component associated with an analysis device can be handled in an efficient and reliable manner if the component is coupled to a holding device, which in particular can be coupled to the analysis device via a base device (as an adapter function).

[0025] In a first embodiment, the component is spaced away from the coupling device in the held state by means of a spacer device (e.g., by a clamping mechanism with several elastic fingers that create a spatial distance between the component and the coupling device of the holding fixture). This can, in particular, enable efficient thermal decoupling of the component, thereby improving the operating conditions (especially the analysis).

[0026] In a second embodiment, a functional coupling is provided between the holding device and the base device, which can be, for example, magnetic and electrical. For instance, a mechanical coupling is provided between the holding device (coupled to the component) and the base device (attached to the analysis device, e.g., in the column oven), and a wired electrical coupling is provided between the holding device (attached to the component) and the base device, wherein the electrical coupling can be opened or closed when the magnetic coupling mechanism is opened or closed.

[0027] The holding device can provide a secure, effortless, functional, and intuitive connection between a component and the base device. This enables reliable data exchange and prevents unauthorized reuse or tampering. EXEMPLARY EXPERIENCE EXAMPLES

[0028] Further preferred configurations are described below.

[0029] According to one embodiment, the spacer device is designed to distance the coupling device and the coupled component from each other such that an air gap remains between the coupling device and the component. This reduces unwanted heat transfer, which can improve the temperature stability of the component, particularly during operation. Furthermore, the air gap can help ensure electrical insulation and reduce mechanical stress. Depending on the application, the air gap can be, for example, in the millimeter or centimeter range.

[0030] According to one embodiment, the spacer device is configured to distance the coupling device and the coupled component from each other in such a way that contact, in particular physical contact, between the coupling device and the component is reduced, preferably minimized (in particular prevented). This reduces the risk of mechanical wear or damage. Furthermore, it prevents unintentional heat transfer, which can increase the service life and reliability of the components. In one embodiment, the coupled component is held by coupling elements or finger elements; however, it is then not in physical contact with the actual coupling device.

[0031] According to one embodiment, the spacer device is configured to distance the coupling device and the coupled component from each other in such a way that contact, in particular thermal contact, between the coupling device and the component is reduced, preferably minimized (in particular prevented). This avoids unwanted heat transfer, which can improve the temperature stability of the component and maintain its functionality.

[0032] According to one embodiment, the spacer device is configured to distance the coupling device and the coupled component from each other such that, during operation of the fluidic analysis device, thermal coupling of the holding device with a flow path is reduced. According to another embodiment, the analysis device is configured to analyze a fluidic sample within the fluidic flow path. This prevents heat from being transferred from the holding device (via the component) to the flow path of the analysis device. This can help to maintain a stable temperature in the flow path and thereby improve the accuracy and reproducibility of the analysis results.

[0033] According to one embodiment, the spacer is (at least partially) elastic. In another embodiment, the spacer is made of an elastic material (e.g., plastic, rubber, etc.). This can have the advantage that the component can be coupled (or attached) in a practical and easy-to-handle manner. Furthermore, an elastic spacer can provide a tolerance so that different types of components (especially with regard to diameter) can be held. This allows the holding device to be used flexibly. Elastic materials such as rubber are also often poor thermal conductors, so a desired reduction / minimization of thermal contact can be improved.

[0034] According to one embodiment, the spacer is connected to the coupling device, and in particular, arranged on it. In one embodiment (see figures), the coupling device can have a concave (inwardly curved) shape for receiving the component. The spacer can then be positioned (e.g., in the form of finger elements) between the space provided by the curvature and the component. This can have the advantage that the spacer is securely attached (in particular, formed integrally with the coupling device) and can hold the component securely.

[0035] According to one embodiment, the spacer device comprises a plurality of spacer elements, particularly separate ones. In another embodiment, the spacer device comprises a plurality of finger elements, particularly separate ones. In the context of the described spacer device, the term "finger element" can refer to a single, elongated, particularly elastic / resilient, component designed to create a gap between the coupling device and the coupled component. Such finger elements can, for example, be designed as elastic or flexible "finger shapes" (rib shapes, rod shapes, web shapes) that project from the coupling device and bring the coupling device and the component into contact only at specific points. This selectively limits both physical and thermal contact, which can minimize unwanted heat transfer and mechanical stress.In one embodiment, the main extension direction of the finger elements is (essentially) oriented perpendicular to the main extension direction of the coupled component.

[0036] According to one embodiment, physical / thermal contact between the coupling device and the component is provided only / exclusively via the spacer elements, in particular finger elements. This can selectively limit the contact area, thereby further reducing unwanted heat transfer and any potential mechanical stresses.

[0037] According to one embodiment, the spacer device, in particular the spacer elements, and further in particular the finger elements, comprises a thermally insulating material or a material with low thermal conductivity (e.g., plastic, rubber, etc.). In one embodiment, the insulating effect is achieved primarily through the air gap. These measures can improve the thermal insulation of the coupled component. According to one embodiment, the spacer device is designed to thermally decouple the coupling device and the component from each other.

[0038] According to one embodiment, the coupling device comprises a first coupling element and a second coupling element. The coupling elements can be components or parts of the coupling device. Preferably, the coupling elements can be connected to each other to hold the component in place. According to one embodiment, the first coupling element and the second coupling element are movable relative to each other, in particular by means of a bending device (e.g., a hinge). This can have the advantage that the coupling elements can be handled in a simple and reliable manner.

[0039] According to one embodiment, the component can be coupled between the first coupling element and the second coupling element by moving the first and second coupling elements relative to each other, in particular by being enclosed / fastened. This allows the component to be held between the coupling elements in a simple yet stable manner (e.g., clamped). To illustrate, the coupling elements can be folded together and thereby act as clamping arms between which the component is clamped (but spaced apart by the spacer device).

[0040] According to one embodiment, the spacer is arranged on the first coupling element (particularly as the first spacer) and / or the second coupling element (particularly as the second spacer). According to one embodiment, the spacer positions the first and second coupling elements apart from the component in the coupled state, particularly in the enclosing state. This can have the advantage that the spacer can be integrated into the simple yet reliable holding mechanism. For example, one coupling element (particularly both coupling elements) can have a spacer that is directly incorporated into the enclosing action. The component can, for instance, be clamped between finger elements, which in turn are pressed against the component by the coupling elements.

[0041] According to one embodiment, the holding device further comprises: a locking device (particularly arranged on the coupling device) designed to close / lock the coupling device. According to one embodiment, this is for locking the coupling elements to one another when the component is coupled to (particularly enclosed with) the coupling device, in order to provide a locked state. In other words, the coupling elements can be fastened to one another (when the component is enclosed or clamped) so that the component is held securely and the coupling elements can no longer separate from each other.

[0042] According to one embodiment, the closing mechanism comprises at least one of the following: snapping, locking, sliding, clicking, or a snap closure. This allows for particularly simple, quick, and reliable closing using established mechanisms.

[0043] According to one embodiment, the locking device is permanently locked. According to another embodiment, the locking device cannot be unlocked non-destructively when locked. According to yet another embodiment, opening the locked locking device leaves marks of destruction. This can have the advantage that the component is and remains uniquely identifiable. In other words, the retaining device cannot be opened (non-destructively) after the coupling elements have been locked. This reliably prevents unauthorized or unwanted opening, or at least makes it clearly identifiable. This can increase the security and integrity of the connection, prevent tampering, and significantly improve reliability and traceability.

[0044] According to one embodiment, the holding device further comprises an information device (in particular, a communication device), specifically configured for storing and / or providing information. In one example, the information may relate to the coupled component and / or the analysis device. The term "information device" can refer to a technical unit (hardware / software) used to store and / or process information. In one example, the information device may include a memory (e.g., memory chip, EPROM) and / or a processor (e.g., microchip). A "communication device" can be an information device configured to communicate the information, in particular to provide, send, or receive it. The information device can be used to permanently store specific data, such as a serial number, usage data, or other identifying characteristics.Furthermore, the communication device can enable the exchange of this data with external devices, for example via a wired or wireless connection. This allows the component to be uniquely identified and its usage history to be traced, which can support automation, safety, and traceability during operation.

[0045] According to one embodiment, the information includes at least one of the following: an identifier, in particular an identification number (e.g., a UID, Universal Identification), a designation, a property, a characteristic, manufacturer information, a state, in particular usage performance, tracking data (where and when the component was installed / used). This allows important information to be securely stored and flexibly retrieved, depending on the application.

[0046] According to one embodiment, the information has at least one of the following characteristics: encrypted, signed, immutable. This allows the information to be protected securely and reliably in the holding device.

[0047] According to one embodiment, the communication device is configured for wireless communication (e.g., RFID, NFC, Bluetooth, WiFi, etc.) and / or wired communication. This allows the information transmission to be flexibly adapted to different requirements and environments. With wired communication, for example, a direct connection (via the base device) can be established with the analysis device (or the control device). In this way, the control system of the analysis device can directly (automatically) read the information and knows exactly which component is used where in the system. The wired connection can be reliable and stable. Furthermore, additional expenses (such as certification for RFID) become obsolete.

[0048] According to one embodiment, the information device is temperature-stable, in particular at least up to 80°C, in particular at least up to 100°C, in particular at least 120°C, and further in particular at least 150°C. This can have the advantage that the holding device can be used flexibly, for example, in a thermostat (in particular a column oven) of the analysis device.

[0049] According to one embodiment, the information device includes a memory / processor, in particular an encapsulated memory / processor. This can have the advantage that the information device is efficiently protected (e.g., against high temperatures). Furthermore, unauthorized access to the stored information can be significantly hindered.

[0050] According to one embodiment, the holding device, in particular the information device, has a sensor, especially a temperature sensor. This can have the advantage that the environment can be monitored efficiently. If the temperature is too high, the holding device can, for example, issue a message (e.g., a warning tone). In another embodiment, the measured value (in particular the temperature) can be output to (or read from) the analysis device. This allows the holding device to be used simultaneously for the sensor (e.g., in a thermostat).

[0051] According to one embodiment, the holding device comprises the component, wherein the component is coupled to the coupling device (and spaced apart from the coupling device by the spacer device). According to one embodiment, the component comprises at least one of the following: a flow path (in particular at least one of the following: a capillary, a channel, a conduit, a fluid line, a hose), a sample separation device (in particular a chromatographic column), a guard column, a temperature control device, a fluid temperature control device for pre-temperature-preserving a fluid and / or the guard column. The guard column can protect the column, e.g., against particles in the sample. The fluid temperature control device can be a fluid temperature control unit (heater) and / or a guard column temperature control unit (heater).

[0052] The term "component" can refer to a single part or functional element that has a relationship (an association) with the analytical apparatus, for example, a separation column, a sensor, an adapter, or another specific element that is connected to the holding device. The component can perform a specific task within the overall system, such as carrying out the chromatographic separation, acquiring measurement data, or providing information. The component can thus be a functionally distinct and identifiable element that enables a desired system function.

[0053] According to one embodiment, the coupling device is designed to couple, in particular enclose, a plurality of different sample separation devices (separation columns) with diameters, particularly in the range of 6 mm to 11 mm. According to another embodiment, the component is a separation column with a diameter in the range of 6 mm to 11 mm, particularly 6 to 9 mm. This can have the advantage that common and frequently used separation columns can be held, and the holding device can be used flexibly for a variety of applications.

[0054] According to one embodiment, the holding device further comprises: a connection device for coupling to a base device and / or to the analysis device. According to one embodiment, this coupling comprises at least one of the following: an electrical coupling, a communicative coupling, or a magnetic coupling. This allows the connection to be both mechanically stable and functionally versatile. Secure power or data transmission, as well as simple and reliable attachment by magnetic forces, can be achieved, which can facilitate the handling and integration of the device. In one embodiment, the base device can couple the holding device (with the coupled component) to the analysis device (or a control device thereof).This allows for high flexibility regarding the mounting device / component, which can be easily and practically replaced (especially if the mounting device / component is permanently or non-destructively connected). A magnetic connection can be simple, practical, and stable in this context. Alternatively or additionally to the mechanical coupling, an electrical coupling and / or communicative coupling (e.g., via electrical contacts such as pins) can be provided. In a preferred example, the mechanical and electrical / communicative couplings can interact within the connection device: connecting the mounting device and the base device creates a mechanical and electrical / communicative coupling, and disconnecting the mounting device and the base device releases the mechanical and electrical / communicative coupling.

[0055] According to one embodiment, the holding device has a first connection device (see above; in particular, having a first electrical contact) and / or a first magnetic coupling. According to another embodiment, the base device has a second connection device (in particular, having a second electrical contact) and / or a second magnetic coupling. According to another embodiment, the first connection device and the second connection device are coupled and / or connectable. As described above, the holding device and the base device can be connected and disconnected in an efficient, stable, and flexible manner. Preferably, functions such as power supply and (data) communication can be maintained (via electrical contacts).

[0056] According to one embodiment, the base device comprises a basic coupling connection for connecting the base device to the analysis device. According to one embodiment, the coupling comprises an electrical coupling and / or a communicative coupling. According to one embodiment, the coupling enables communication, particularly wired communication, between the communication device of the holding device and the analysis device (or its control device). According to one embodiment, information regarding the component can be transmitted from the communication device to the analysis device. This can have the advantage that the holding device (with component) (often changed dynamically during operation) can be coupled efficiently and reliably to the analysis device via the base device (usually fixed, static during operation) (as an adapter). The control system of the analysis device can then, for example,Information from the information device can be read automatically. In one embodiment, the basic coupling device can be coupled to an existing structure of the analysis device, e.g., in the thermostat (see...). Fig. 5 and Fig. 6).

[0057] According to one embodiment, the method further comprises: communication, particularly via wired connection, between the holding device and the analysis device (particularly via the intermediate base device (as an adapter)). According to one embodiment, the method comprises: providing information regarding the coupled component to the analysis device and / or reading sensor data. According to one embodiment, the method comprises: providing information regarding the analysis device to the holding device. This enables efficient and secure information exchange between the components involved, which can improve the automation, traceability, and adaptability of the overall system.

[0058] According to one embodiment, the analytical device further comprises: a temperature control chamber, e.g., a thermostat, in particular a column oven. According to one embodiment, the temperature control chamber has a coupling area, in particular a groove, furthermore particularly with a triangular cross-section in the preferred direction. According to one embodiment, the base device (in particular the base coupling connection) can be coupled to or is coupled to the coupling area of ​​the temperature control chamber. Often, a heat exchanger is provided in the area of ​​analytical devices (in particular HPLC) which has at least one, in particular several, parallel grooves. These usually have a triangular cross-section (compare Fig. 6) Conventionally, fasteners are provided on the raised sections between the grooves, to which retaining clips for the separating column(s) are then attached. For example, such a retaining clip can extend across a groove and be attached to the respective raised sections. In one embodiment, such (existing) fasteners can be used as a coupling area for the base device. In other words, the base device can be attached in a similar manner to the retaining clips. This can save additional fastening costs.

[0059] In one embodiment, the mounting device is easily attached to the column at an intuitively accessible location. No rope or cable is attached to the column that could obstruct anything in the heated area of ​​the thermostat. Furthermore, the problem of covering large portions of the column surface is solved by an air gap between the column and the coupling device.

[0060] According to one embodiment, the analytical device is configured as a sample separation device. According to another embodiment, the analytical device includes a fluid drive for driving a mobile phase and a fluidic sample injected into the mobile phase. According to another embodiment, the analytical device includes a sample separation unit for separating the fluidic sample injected into the mobile phase. According to another embodiment, the analytical device is configured to analyze at least one physical, chemical, and / or biological parameter of the fluidic sample. According to another embodiment, the analytical device is configured as a sample separation unit for separating the fluidic sample.

[0061] Within the scope of this application, the term "sample separation device" can be understood to mean, in particular, a device for analyzing a fluidic sample, especially into different fractions. For this purpose, components of the fluidic sample can first be adsorbed on the sample separation device and then desorbed separately (especially fractionally). For example, such a sample separation device can be configured as a chromatographic separation column.

[0062] According to one embodiment, the analytical device is a chromatography device, in particular a liquid chromatography device, a gas chromatography device, an SFC (supercritical liquid chromatography) device or an HPLC (high-performance liquid chromatography) device.

[0063] In one embodiment, the analysis device is configured as a microfluidic device. In another embodiment, the analysis device is configured as a nanofluidic device.

[0064] According to one embodiment, the sample separation device is designed as a chromatographic separation device, in particular as a chromatography separation column.

[0065] According to one embodiment, the fluid drive is configured to drive the mobile phase and the fluidic sample under high pressure.

[0066] According to one embodiment, the fluid drive is configured to drive the mobile phase and the fluidic sample with a pressure of at least 200 bar, in particular at least 500 bar, in particular at least 1000 bar, further in particular at least 1200 bar, further in particular at least 1500 bar.

[0067] According to one embodiment, the analysis device has a detector for detecting the analyzed, in particular separated, fluidic sample.

[0068] According to one embodiment, the analysis device includes a fractionator for fractionating separate fractions of the fluidic sample.

[0069] The analytical instrument can be a microfluidic measuring device, a life science instrument, a liquid chromatograph, a gas chromatograph, an HPLC (high-performance liquid chromatography), an UHPLC system, or an SFC (supercritical liquid chromatography) instrument. However, many other applications are possible.

[0070] According to one embodiment, the sample separation device can be designed as a chromatographic separation device, in particular as a chromatographic column. In chromatographic separation, the chromatographic column can be provided with an adsorption medium. The fluidic sample can be retained on this medium and only subsequently released fractionally in the presence of a specific solvent composition, thus achieving the separation of the sample into its fractions.

[0071] A pumping system for conveying fluid can, for example, be configured to transport the fluid or mobile phase through the system at high pressure, for example, several hundred bar up to 1000 bar or more. The analytical device can include a sample injector for introducing the sample into the fluidic separation path. Such a sample injector can have a sample or injection needle, connectable to a needle seat, within a corresponding fluid path, wherein the sample needle can be extended from this needle seat to receive the sample. After reinserting the sample needle into the needle seat, the sample can be located in a fluid path that can be switched into the separation path of the system, for example, by switching a valve. In another embodiment of the invention, a sample injector or sampler can be used with a sample needle that operates without a needle seat.

[0072] The analytical device may include a fraction collector for collecting the separated components. Such a fraction collector can, for example, direct the different components of the separated sample into separate liquid containers. Alternatively, the analyzed sample can be directed to a discharge container.

[0073] Preferably, the analytical device can include a detector for detecting the separated components. Such a detector can generate a signal that can be observed and / or recorded, and which is indicative of the presence and quantity of the sample components in the fluid flowing through the system. BRIEF DESCRIPTION OF THE FIGURES

[0074] Other objectives and many of the accompanying advantages of exemplary embodiments of the present invention will become readily apparent and more readily understood with reference to the following more detailed description of exemplary embodiments in conjunction with the accompanying drawings. Features that are essentially or functionally the same or similar are designated with the same reference numerals. Fig. Figure 1 shows an analysis device configured as a chromatography device, according to an exemplary embodiment of the invention. Fig. 2A shows a holding device in the open position, Fig. 2B shows the holding device with coupled component, and Fig. Figure 2C shows the holding device in the closed state, according to exemplary embodiments of the invention. Fig. Figure 3A shows the base device in a side view, and Fig. Figure 3B shows the basic device in front view, according to exemplary embodiments of the invention. Fig. Figure 4A shows a magnetic / electrical / communicative coupling between the base device and the holding device, and Fig. Figure 4B shows a holding system with a coupled component, according to an exemplary embodiment of the invention. The Fig. 5 and Fig. Figure 6 shows different views of a holding system with a separation column as a coupled component in a column oven of an analysis device, according to an exemplary embodiment of the invention. DETAILED DESCRIPTION OF THE FIGURES

[0075] The representation in the drawing is schematic.

[0076] Fig. Figure 1 shows the basic structure of an HPLC system as an example of an analytical device 10 designed as a sample separation device or chromatography device, according to an exemplary embodiment of the invention, as it can be used, for example, for liquid chromatography. A fluid conveying device or fluid drive 20, which is supplied with solvents from a feed device 25 (or consumables from a container), drives a mobile phase through a sample separation device 30 (such as a chromatographic column) which contains a stationary phase.

[0077] The solvents are a consumable material which is stored in one or more containers. The supply device usually includes a first fluid component source (e.g. first container) for providing a first fluid or a first solvent component A (e.g. water) and a second fluid component source (e.g. second container) for providing another second fluid or a second solvent component B (e.g. an organic solvent).

[0078] An optional degasser 27 can degasse the solvents supplied by the first fluid component source and the second fluid component source before they are fed to the fluid drive 20. A sample introduction unit, which can also be referred to as an injector 40 (sampler), is arranged between the fluid drive 20 and the sample separation device 30 to first draw a sample liquid or fluidic sample from a sample container into a sample receiving volume in an injector path, and subsequently introduce it into a fluidic separation path between the fluid drive 20 and the sample separation device 30 by switching an injection valve of the injector 40.The intake of fluidic sample from the sample container can be achieved in particular by extending a sample needle from a sample seat and extending it into the sample container, drawing fluidic sample from the sample container through the sample needle into the sample intake volume by means of a fluid conveying device designed as a metering device, and then extending the sample needle back into the needle seat.

[0079] The stationary phase of the sample separation device 30 is designed to separate components of the sample. The sample separation device 30 is arranged in a temperature control chamber 35 (or a column oven). The fluid path from the fluid drive 20 is coupled to an inlet of the sample separation domain, while an outlet of the sample separation domain is coupled to a detector 50.

[0080] The detector 50, which may include a flow cell, detects separated components of the sample. A fractionator 60 can be provided to discharge the separated components of the sample into designated containers. Unneeded liquids can be discharged into a drain or waste line.

[0081] While a fluid path between the fluid drive 20 and the sample separation device 30 is typically under high pressure, the sample fluid is initially introduced under normal pressure into a section separate from the fluid path, namely the sample loop or sample intake volume, of the sample delivery unit or injector 40. The sample fluid is then introduced into the separation path under high pressure. A sample loop (also referred to as a sample intake volume) can be understood as a section of a fluid line designed to receive or temporarily store a predetermined quantity of fluidic sample.Preferably, before the sample liquid, which is initially under normal pressure, is switched into the sample intake volume, the contents of the sample intake volume are brought to the system pressure of the HPLC-designed analytical device 10 by means of a metering device in the form of the fluid conveying device.

[0082] A control unit or control system 70 controls the individual components or elements 20, 25, 30, 40, 50, 60, etc., of the analysis device 10. Each of these components can have a separate housing, or two or more components can be arranged in the same housing.

[0083] Fig. Figure 2A shows a holding device 110 in the open state, according to an exemplary embodiment of the invention. The coupling device 111 has a first coupling element 111a and a second coupling element 111b, which are movable relative to each other by means of a bending device 112. In the example shown, the coupling elements 111a and 111b are concavely curved outwards (with respect to the component to be coupled), thereby creating additional space (clearance). A spacer device 115 is arranged on the first coupling element 111a as a first spacer device 115a and on the second coupling element 111b as a second spacer device 115b (such that the spacer device 115 distances the first coupling element 111a and the second coupling element 111b from the component in the coupled / enclosing state).The spacer devices 115a, 115b are each designed as elongated finger elements which are attached in the curved free space of the coupling elements 111a, 111b and protrude from there in the direction of the component to be coupled.

[0084] The holding device 110 has a locking device 116, which is arranged on the coupling device 111 and is configured to lock the coupling elements 111a and 111b together when the component 30 is enclosed by the coupling device 111, in order to provide a locked state. The locking action includes, for example, snapping, latching, or clicking. Preferably, the locking device 116 cannot be released (non-destructively) in the locked state.

[0085] The holding device 110 includes an information device 130 (centrally located between the coupling elements 111a, 111b next to the bending device 112), configured to store and / or provide information regarding the coupled component 30 and / or the analysis device 10. For this purpose, the information device 130 has a memory (in particular temperature-stable; e.g., EPROM) that stores the information (and enables readout, in particular via wired connection). The information includes, for example, a unique identification number (UID).

[0086] Fig. Figure 2B shows the holding device 110 with coupled component 30, according to an exemplary embodiment of the invention. The component 30 can be enclosed between the first coupling element 111a and the second coupling element 111b by moving the first coupling element 111a and the second coupling element 111b relative to each other. The component 30 is oriented perpendicular to the main extension direction of the open holding device 110 and is inserted into the concave curvature of the second coupling element 111b.

[0087] Fig. Figure 2C shows the holding device 100 in the closed state (without component 30 for clarity), according to an exemplary embodiment of the invention. In this view, the first connecting device 140 can be seen (this is arranged opposite the information device and in the Fig. 2A and Fig. 2B (therefore not visible). Preferably, the first connecting device 140 and the information device 130 are connected or electrically / communicatively coupled. The first connecting device 140 is configured for magnetic coupling with a second connecting device 145 of the base device 120. In addition to the magnetic contact surface, the first connecting device 140 has an electrical contact 141 for electrical / communicative contacting / coupling with the base device 120.

[0088] Fig. Figure 3A shows the base device 120 in a side view, and Fig. Figure 3B shows the base device 120 in a front view, according to exemplary embodiments of the invention. The base device 120 has a second connecting device 145 for (magnetic) connection to the first connecting device 140 of the holding device 110. In addition to the magnetic contact surface, the second connecting device 145 has a second electrical contact 146, implemented here as three pins. This electrical contact 146 can supply a current to the holding device 110 and / or transmit data as electrical signals; for example, the memory of the information device 130 of the holding device 110 can be read out.

[0089] The base device 120 also has a base coupling device 150 for coupling the base device 120 to the analysis device 10 (e.g., in a thermostat of the analysis device 10). This allows the base device 120 to serve as an adapter between the holding device 110 and the analysis device 10. In the example shown, the base coupling device 150 has an opening 151 for a tool (here, an Allen key), so that the base coupling device 150 can be easily mounted (e.g., screwed on).

[0090] Fig. Figure 4A shows a magnetic / electrical / communicative coupling between the base device 120 and the holding device 110, according to an exemplary embodiment of the invention. Here, component 30 is a separating column held between the finger elements of the spacer device 115; an air gap 160 remains between the coupling device 111 and component 30. The holding device 110 is closed via the locking device 116 and thus firmly attached to component 30. The components in the Fig. 2A and Fig. The information device 130 shown in Figure 2B is secured by a cover flap (lid) 113. The first connecting device 140 of the holding device 110 is moved to the second connecting device 145 of the base device 120 to provide magnetic contact between the respective magnetic contact surfaces. Furthermore, an electrical / communicative connection can simultaneously be provided via the electrical contacts 141, 146.

[0091] Fig. Figure 4B shows a holding system 100 with a coupled component 30, according to an exemplary embodiment of the invention. Based on the illustration in Fig. 4A the first connecting device 140 and the second connecting device 145 were now joined together.

[0092] Figure 5 and Fig. Figure 6 shows different views of a holding system 100 with a separation column as a coupled component 30 in a thermostat / column oven 35 of an analysis device 10, according to an exemplary embodiment of the invention. The holding system 100 is configured as for the Fig. 4A and Fig. 4B already described above. The separating column 30 is fastened in the thermostat 35 by column holder 38 (retaining clips) in addition to the holding system 100.

[0093] The thermostat 35 has a heat exchanger block 37 in which (parallel) grooves 36 alternate with protrusions. In cross-section, these are triangular. Column holder coupling devices 39 are mounted on the protrusions. The known column holders 38 can each be attached between two column holder coupling devices 39, so that one column holder 38 spans one groove 36; see also GB 2522056 A.

[0094] In the same way (and thus without additional effort) the base coupling device 150 of the base device 120 can be attached between two column holder coupling devices 39 and thus span the groove 36 ( Fig. 6) The base device 120 can thus be easily attached and the holding device 110 can be flexibly coupled and decoupled; e.g. by screwing in a base holder 152 of the base coupling device 150.

[0095] In other words, the base device 120 is clipped into the existing groove 36 of the pre-column heater (the cable to the electronics is not shown). The magnetic connectors 145 are either snapped into the plastic housing or glued in place. Three pins 146 are shown here, as this is standard for magnetic connectors. However, two connections are sufficient for exchanging the information stored in the chip of the mounting device 110.

[0096] The cross-sectional view of Fig. Figure 6 also clearly shows how the component 30 is held at specific points by the finger elements 115a,b and an air gap 160 remains between component 30 and coupling elements 111a, 111b of the coupling device 111. Reference sign 10 Analysis device 20 Fluid drive 25 Feeding device, container 27 degassers 30-component separation column 35 Tempering chamber, column oven 36 Heat exchanger groove / slot 37 Heat exchanger block 38 column holders 39 Column holder coupling device 40 injectors 50 Detector 60 fractionators 70 Control unit 100 holding system 110 Holding device 111 Coupling device 111a First coupling element 111b Second coupling element 112 Bending device, hinge 113 Cover 115 Spacer device 115a First spacer element 115b Second spacer element 116 Locking device 120 Base device 130 Information device, communication device 140 First magnetic connecting device 141 First electrical contact, holding device 141 Second connecting device, magnetic 146 Second electrical contact, base device 150 basic coupling device 151 Opening (for tool) 152 base holders 160 air gap QUOTES INCLUDED IN THE DESCRIPTION

[0000] This list of documents cited by the applicant was automatically generated and is included solely for the reader's convenience. The list is not part of the German patent or utility model application. The DPMA accepts no liability for any errors or omissions. Cited patent literature

[0000] EP 0,309,596 B1

[0003] GB 2522056

[0093]

Claims

[1] A holding device (110) for a component (30) associated with an analysis device (10), wherein the holding device (110) comprises: a coupling device (111) for coupling the component (30) such that the coupling device (111) at least partially encloses the component (30) to be coupled; and a spacer device (115) for spacing the coupling device (111) from the coupled component (30). [2] The holding device (10) according to claim 1, wherein the spacer device (115) is configured to space the coupling device (111) and the coupled component (30) apart from each other such that an air gap (160) remains between the coupling device (111) and the component (30), and / or a contact, in particular a physical contact, between the coupling device (111) and the component (30) is reduced, preferably minimized, and / or a contact, in particular a thermal contact, between the coupling device (111) and the component (30) is reduced, preferably minimized; and / or in the operation of the fluidic analysis device (10) a thermal coupling of the holding device (110) with a flow path is reduced, in particular wherein the analysis device (10) is configured to analyze a fluidic sample in the fluidic flow path. [3] The holding device (110) according to claim 1 or 2, wherein the spacer device (115) has at least one of the following features: wherein the spacer device (115) is at least partially elastic; wherein the spacer device (115) is connected to the coupling device (110), in particular arranged on it; wherein the spacer device (115) comprises a plurality of spacer elements, in particular separate from one another, especially finger elements, in particular wherein a physical / thermal contact between the coupling device (111) and the component (30) exists only via the spacer elements, in particular finger elements; wherein the spacer device (115), in particular the spacer elements, and further in particular the finger elements, comprises a thermally insulating material; wherein the spacer device (115) is configured to thermally decouple the coupling device (111) and the component (30) from each other. [4] The holding device (110) according to one of the preceding claims, wherein the coupling device (111) comprises: a first coupling element (111a) and a second coupling element (111b), wherein the first coupling element (111a) and the second coupling element (111b) are movable relative to each other, in particular via a bending device (112), and wherein the component (30) between the first coupling element (111a) and the second coupling element (111b) can be coupled to each other, in particular enclosed, by moving the first coupling element (111a) and the second coupling element (111b). [5] The holding device (110) according to one of the preceding claims, wherein the spacer device (115) is arranged on the first coupling element (111a), in particular as the first spacer device (115a), and / or the second coupling element (111b), in particular as the second spacer device (115b), in particular such that the spacer device (115) spaces the first coupling element (111a) and the second coupling element (111b) away from the component (30) in the coupled state, in particular the enclosing state. [6] The holding device (110) according to one of the preceding claims, further comprising: a locking device (116), in particular arranged on the coupling device (111), configured to close the coupling device (111), in particular to close the coupling elements (111a, 111b) to each other when the component (30) is coupled to the coupling device (111), in particular enclosed, in order to provide a closed state. [7] The holding device (110) according to one of the preceding claims, wherein the closing by the closing device (116) has at least one of the following features: wherein the closing mechanism comprises at least one of the following: a snapping, a locking, a sliding, a clicking, a snap closure; wherein the locking device (116) is irremovable in the locked state; wherein the locking device (116) cannot be released without damage when locked; Opening the locked locking device (116) leaves damage marks. [8] The holding device (110) according to one of the preceding claims, further comprising: an information device (130), in particular a communication device, designed to store and / or provide information, in particular with regard to the coupled component (30) and / or the analysis device (10). [9] The holding device (110) according to one of the preceding claims, wherein the information device has at least one of the following features: wherein the information includes at least one of the following: an identifier, in particular an identification number, a designation, a property, a characteristic, manufacturer information, a state, in particular a usage performance, tracking data; where the information has at least one of the following characteristics: encrypted, signed, immutable; wherein the communication device (130) is configured for wireless communication and / or wired communication; wherein the information device (130) is temperature stable, in particular at least up to 80°C, in particular at least up to 100°C, and further in particular at least up to 120°C; wherein the information device (130) has a memory, in particular a potted memory; wherein the holding device (110), in particular the information device (130), comprises a sensor, in particular a temperature sensor. [10] The holding device (110) according to one of the preceding claims, further comprising: the component (30), wherein the component (30) is coupled to the coupling device (111), in particular wherein the component (30) comprises at least one of the following: a flow path, in particular a capillary, a sample separation device, a chromatographic separation column, a guard column, a temperature control device, a fluid temperature control device for pre-temperature control of a fluid and / or the guard column; and / or wherein the coupling device (111) is configured for coupling, in particular enclosing, a plurality of different separating column diameters, in particular in the range of 6 mm to 11 mm. [11] The holding device (110) according to one of the preceding claims, further comprising: a connecting device (140) for coupling with a base device (120) and / or with the analysis device (10), in particular via at least one of the following: an electrical coupling (141), a communicative coupling, a magnetic coupling. [12] A holding system (100) for a component (30) associated with an analysis device (10), wherein the holding system (100) comprises: a holding device (110) comprising a coupling device (111) for coupling the component (30); and a base device (120) configured for coupling the holding device (110) to the analysis device (10), in particular via a base coupling connection (150); wherein the holding device (110) and the base device (120) are, in particular, detachably, coupled or connectable, and where the coupling includes electrical coupling and / or magnetic coupling and / or communicative coupling. [13] The holding system (100) according to claim 12, wherein the holding device (110) has a first connecting device (140), in particular having a first electrical contact (141) and / or a first magnetic coupling; wherein the base device (120) has a second connecting device (145), in particular having a second electrical contact (146) and / or a second magnetic coupling; and wherein the first connecting device (140) and the second connecting device (145) are coupled and / or can be coupled. [14] The holding system (100) according to claim 12 or 13, wherein the base device (120) comprises: a basic coupling connection (150) for coupling the base device (120) to the analysis device (10), in particular where the coupling has an electrical coupling and / or a communicative coupling, further, in particular, the coupling enables communication, especially wired communication, between the communication device (130) of the holding device (110) and the analysis device (10), furthermore, in particular, the information regarding component (30) is transferable from the communication device (110) to the analysis device (10). [15] An analysis device (10) comprising the holding device (110) or the holding system (100) according to any one of the preceding claims, in particular further exhibiting at least one of the following characteristics: wherein the analysis device (10) is in particular configured as a sample separation device for separating a fluidic sample in a sample separation device (30), in particular a chromatographic separation column. the analysis device (10) is configured to analyze at least one physical, chemical and / or biological parameter of the fluidic sample; the analysis device (10) is configured as a sample separation device for separating the fluidic sample; the analytical device (10) is a chromatography device, in particular a liquid chromatography device, a gas chromatography device, an SFC (supercritical liquid chromatography) device or an HPLC (high-performance liquid chromatography) device; the analysis device (10) is configured as a microfluidic device; the analysis device (10) is configured as a nanofluidic device; The sample separation device (30) is designed as a chromatographic separation device, in particular as a chromatography separation column; The fluid drive (20) is configured to drive the mobile phase and the fluidic sample under high pressure; The fluid drive (20) is configured to drive the mobile phase and the fluidic sample with a pressure of at least 200 bar, in particular at least 500 bar, in particular at least 1000 bar, and further in particular at least 1200 bar; the analysis device (10) has a detector (50) for detecting the analyzed, in particular separated, fluidic sample; The analysis device (10) has a fractionator (60) for fractionating separate fractions of the fluidic sample. [16] The analysis device (10) according to claim 15, further comprising: a temperature control chamber (35), in particular a thermostat, and further in particular a column furnace; wherein the temperature control chamber (35) has a coupling area, in particular a groove (36), further in particular with a triangular cross-section in the preferred direction; and wherein the base device (120), in particular the base coupling connection (150), can be coupled or is coupled to the coupling area of ​​the temperature control chamber (35). [17] A method for handling a component (30) associated with an analysis device (10), wherein the method comprises: Coupling the component (30) with a holding device (110) such that a coupling device (111) of the holding device (110) at least partially encloses the coupled component (30); and in this process Spacing the coupling device (111) away from the coupled component (30), in particular via an air gap (160). [18] A process comprising: Coupling a component (30) associated with an analysis device (10) to a holding device (110); and Connecting the holding device (110) to a base device (120) via at least one of the following: an electrical coupling, a communicative coupling, a magnetic coupling; and in particular Coupling the holding device (110) and / or the base device (120) to the analysis device (10). [19] The method according to claim 17 or 18, further comprising: Communicate, in particular via wired connection, between the holding device (110) and the analysis device (10), in particular via the intermediate base device (120); in particular Providing information regarding the coupled component (30) to the analysis device (10), and / or Reading sensor data, and / or Providing information to the holding device regarding the analysis device. [20] Using a holding device (110) or a holding system (100) according to any one of the preceding claims 1 to 14 to couple a component (30) in a temperature control chamber (35) of an analysis device (10) and to read out information relating to the coupled component (30) by wired connection.

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