Composition, dosage form and associated dietary supplement for maintaining and / or restoring mental performance and for stress reduction

Abstract

Composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg.

Description

Brief description of the invention The present invention relates to a composition, dosage form and associated food supplement for maintaining and / or restoring mental performance and for stress reduction. The brain, as an organ of the central human nervous system, influences every single function in the body – from regulating our heartbeat to complex thought processes. The reception and processing of sensory information is a crucial aspect of its function. Furthermore, it is also responsible for controlling the muscles and the hormonal system, among other things. Consequently, brain health is a cornerstone for a healthy, long, and fulfilling life and lays the foundation for long-term mental and physical performance. Numerous formulations and dietary supplements are known from current technology that promise, for example, relief from forgetfulness and concentration problems, and are intended to keep the brain fit into old age. The disadvantage of these known products is that they mostly a) use only single active ingredients or provide them in an ineffective combination; b) the dosage of the active ingredients is either too high or too low; c) the ingredients of some products, such as "Novel Foods," have not been tested. The object of the present invention is therefore to provide an improved composition comprising carefully selected active ingredients. The present invention therefore relates to a composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg. In a preferred embodiment, the composition comprises the following components: a) 150 mg to 300 mg of an omega-3 complex, comprising between 75 mg and 300 mg of EPA and DHA, preferably between 150 mg and 300 mg of EPA and DHA; b) 100 mg of Brahmi extract, comprising 45 mg of bacopasides; c) 100 mg of Ginkgo biloba extract, of which 3 mg are ginkgo flavonoids; d) 50 mg of Panax ginseng extract, of which 10 mg are ginsenosides; e) 150 mg of taurine; f) 100 mg of phosphatidylserine; g) 6 mg of vitamin B5; and h) 1.1 mg of thiamin. The present invention also relates to a dosage form containing the aforementioned composition, or comprising the following composition: a) 150 mg to 300 mg of an omega-3 complex, comprising between 75 mg and 300 mg of EPA and DHA, preferably between 150 mg and 300 mg of EPA and DHA; b) 50 mg of Brahmi extract, comprising 22.5 mg of bacopasides; c) 50 mg of Ginkgo biloba extract, of which 1.5 mg are ginkgo flavonoids; d) 25 mg of Panax ginseng extract, of which 5 mg are ginsenosides; e) 75 mg of taurine; f) 50 mg of phosphatidylserine; g) 3 mg of vitamin B5; and h) 0.55 mg of thiamin. The dosage form is preferably a capsule or tablet. The dosage form must include at least one additive in one aspect. This additive may be, for example, a filler, a disintegration accelerator, a colorant, a film former, and / or a thickening agent. Furthermore, in one embodiment, the dosage form may also include at least one excipient. The excipient is preferably sugar, binder, lubricant, oil, wax, gelatin, magnesium stearate, talc, carboxylpolymethylene, carboxylmethylcellulose, cellulose acetate phthalate, and / or polyvinyl acetate. In a particularly preferred aspect of the invention, the dosage form is a hard gelatin capsule, a soft gelatin capsule, an enteric-coated capsule, a hydroxypropylmethylcellulose (HPMC) capsule, a modified-release capsule and / or a film-coated capsule. Furthermore, the invention also relates to one of the above compositions or a previously described dosage form as a dietary supplement for maintaining and / or restoring mental performance and for stress reduction. The object of the invention is described in particular by a composition according to claim 1, the dosage form according to claim 3, and the dietary supplement according to claim 10. Advantageous embodiments with expedient further developments of the invention are specified in the remaining claims. Detailed description of the invention The present invention relates to a composition, a dosage form and an associated food supplement for maintaining and / or restoring mental performance and for stress reduction. The brain is an essential component of the human body, regulating, controlling, and processing vital bodily functions. To support the brain's activity and enhance its performance, a formula has been developed containing a carefully calibrated and balanced combination of nutrients, substances, and other components. This formula can be administered as a nutritional supplement and / or dietary support to promote the body's natural autophagy process. In the following, the articles “ein” and all derivatives thereof, as used here, should generally be understood as “one / an / an or several”, unless otherwise specified or the singular form is evident from the context. Where the terms “contains”, “has”, “possesses” and the like are used in the description or claims, these terms shall be understood in the same way as the terms “possessing” or “comprising”, i.e., not exhaustively, unless explicitly stated otherwise. Nutrients within the meaning of the present invention include vitamins, minerals, trace elements, secondary plant compounds, amino acids, amino acid derivatives, components of amino acids, intermediates and / or glycosaminoglycans. In the present invention, the term "substance" shall be understood to mean a plant-based active ingredient that can be used for dietary supplement purposes. The use of the substance, an extract thereof, or a preparation made from the substance shall be generally considered the active ingredient in the following, regardless of whether the efficacy-determining, i.e., therapeutically active, constituents are known. The term "extract" here includes not only dry extracts but also oils or thick extracts, which can be obtained from natural starting materials such as plant parts and may consist of a mixture of different components. Surprisingly, it was found that a combination of selected ingredients led to increased attention and mental performance. The composition according to the invention resulted in a reduction of stress levels in stressful situations, leading to better focus and improved concentration. The invention therefore relates to a composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg. Omega-3 fatty acids are essential polyunsaturated fatty acids that the body cannot produce itself. The two most important forms of omega-3 fatty acids are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are fundamental building blocks of cell membranes and influence numerous metabolic processes in the body. DHA, for example, is quantitatively the most important omega-3 fatty acid in the brain and is essential for the structure and function of neuronal cell membranes. Studies have shown that regular omega-3 supplementation can reduce the risk of dementia and cognitive decline by approximately 20%. In a preferred embodiment, the omega-3 fatty acid complex described here comprises 75% to 95%, and in particular 80% to 90%, of DHA and EPA. Brahmi, also known as Bacopa monnieri, is a traditional Ayurvedic medicinal plant whose active ingredients, especially bacosides, contribute to improved brain function. Studies show that daily intake of Brahmi can improve verbal learning, memory formation, and recall, and significantly reduce depression, anxiety, and stress. Ginkgo biloba is one of the oldest trees in the world and has been used in traditional medicine for centuries. The active ingredients of ginkgo are primarily flavonoids and terpenoids. Scientific studies have shown diverse effects of ginkgo biloba on cognitive performance, with daily intake improving reaction time and concentration, among other things. Panax ginseng is a traditional medicinal plant that has been used in Asian medicine for millennia. Its bioactive compounds, particularly ginsenosides, are responsible for its health-promoting properties, especially improved cognitive function, which have been observed in numerous studies. Taurine is a sulfur-containing amino acid. It occurs naturally in the human body and is found in particularly high concentrations in the brain, eyes, heart, and muscles. Unlike other amino acids, taurine is not used to build proteins but is considered a conditionally essential amino acid. This means that while the body can produce it itself, its need increases during times of illness and stress. Taurine works by modulating neurotransmitters, especially GABA, and supports the stabilization of cell membranes in the brain. Phosphatidylserine is an essential phospholipid found in particularly high concentrations in the membranes of brain cells. Phosphatidylserine plays a central role in communication between nerve cells and is involved in numerous cognitive functions such as memory, learning, and concentration. Studies have shown that phosphatidylserine supplementation leads to significant improvements in short-term memory, attention, and impulsive behavior. Pantothenic acid, also known as vitamin B5, is a water-soluble vitamin and an essential nutrient that serves as a precursor for the synthesis of coenzyme A (CoA) and acyl carrier proteins. Pantothenic acid is involved in the synthesis of the neurotransmitter acetylcholine, which is required for cognitive processes and memory. Vitamin B1, also known as thiamin, is a water-soluble vitamin that plays a central role in energy metabolism. Studies have shown that adequate vitamin B1 intake can improve mental processing speed and concentration. The composition according to the invention combines the latest findings from neuroscience and combines evidence-based ingredients into a unique formulation to supply the brain with valuable nutrients every day, thereby promoting better concentration, processing speed and brain health. Preliminary results showed improved concentration when the formula was taken regularly and contained the following amounts: a) 150 mg to 300 mg of an omega-3 complex comprising between 75 mg and 300 mg of EPA and DHA, preferably between 150 mg and 300 mg of EPA and DHA; b) 100 mg of Brahmi extract comprising 45 mg of bacopasides; c) 100 mg of Ginkgo biloba extract, of which 3 mg are ginkgo flavonoids; d) 50 mg of Panax ginseng extract, of which 10 mg are ginsenosides; e) 150 mg of taurine; f) 100 mg of phosphatidylserine; g) 6 mg of vitamin B5; and h) 1.1 mg of thiamin. In a particularly preferred embodiment, the composition, which is especially suitable for maintaining and / or restoring mental performance and for stress reduction, has no further components. The composition described above represents the daily dose of the nutrients or components. A daily dose is understood to be the amount of the components of the composition that is or should be ingested per day. Consequently, the amount of the components of the composition may be reduced in a dosage form such as a capsule, requiring the composition to be administered more than once daily. In a preferred embodiment, the daily dose is achieved by two capsules, lozenges, tablets, pills, coated tablets, powder sachets, liquid ampoules, or similar containers.Consequently, the composition within such a dosage form comprises the following amounts: a) 75 mg to 150 mg of an omega-3 complex, preferably comprising 37.5 mg to 75 mg EPA and DHA; b) 50 mg Brahmi extract, comprising 22.5 mg Bacopasides; c) 50 mg Ginkgo Biloba extract, of which 1.5 mg Ginkgo flavonoids; d) 25 mg Panax Ginseng extract, of which 5 mg Ginsenosides; e) 75 mg Taurine; f) 50 mg Phosphatidylserine; g) 3 mg Vitamin B5; and h) 0.55 mg Thiamin. The present invention therefore relates to a dosage form, for example, but not limited to, the following: solution, syrup, juice, oil, medicinal water, tincture, tea, injection and infusion solution, percolate, spray, powder, granules, tablet, film-coated tablet, coated tablet, soft capsule, hard capsule, effervescent tablet, pill, stick, stick, caplet, suspension, emulsion, paste, cream, ointment, gel, suppository, liniment, electuary, buccal tablet, nanosuspension, plaster, transdermal patch, melt film and / or implant. The dosage form as a food supplement comprises one of the aforementioned compositions according to the invention. The term "food supplement" is used in particular for a foodstuff intended to supplement the normal diet.The dietary supplement comprises at least one nutrient or other substance that has a potential nutritional and / or physiological effect. The at least one ingredient, for example in the form of a nutrient, is present in a defined, measured quantity. The dietary supplement is preferably designed as a dosage form containing defined amounts of the nutrient or corresponding composition. In a particularly preferred embodiment, the composition is administered in the form of a capsule or tablet. The term "capsule" as used in this invention refers to a solid composition enclosed in a hard or soft shell of varying shape or size, for oral administration.Examples of capsules according to the invention include, but are not limited to, the following: hard gelatin capsules, starch capsules, soft gelatin capsules, microcapsules, gastro-resistant capsules, microcapsules, starch capsules, hydroxypropyl methylcellulose (HPMC) capsules, modified-release capsules, or film-coated capsules. In one embodiment, however, it may also be provided that the nutrient, substance, composition, and / or components are mixed with an inert carrier and then encapsulated. Inert carriers include, but are not limited to, cellulose, microcrystalline cellulose, hydroxypropyl methylcellulose, lactose, and / or sorbitol. Dosage forms with a composition according to the invention may further comprise additives in one aspect.The at least one additive includes, for example, but is not limited to, the following: fillers, disintegration accelerators, colorants, thickeners, film formers, oils, waxes, and others. In contrast to a capsule, the term "tablet" describes a solid body comprising the composition according to the invention and at least one excipient. The excipient may, for example, but is not limited to, the following: sugars, binders, lubricants, and similar substances. The at least one excipient may include, but is not limited to, dextrose, oil, wax, sorbitol, mannitol, polyvinylpyrrolidone, corn starch, alginic acid, starch or gelatin, magnesium stearate, talc, carboxylpolymethylene, carboxylmethylcellulose, cellulose acetate phthalate, and / or polyvinyl acetate. The at least one excipient may also be used in other dosage forms. In one aspect of the invention, the dosage form as a dietary supplement comprises at least one composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg. In a preferred embodiment, the dosage form as a dietary supplement comprises a composition comprising the following substances and components: a) 150 mg to 300 mg of an omega-3 complex, comprising between 75 mg and 300 mg of EPA and DHA, preferably between 150 mg and 300 mg of EPA and DHA; b) 100 mg of Brahmi extract, comprising 45 mg of bacopasides; c) 100 mg of Ginkgo biloba extract, of which 3 mg are ginkgo flavonoids; d) 50 mg of Panax ginseng extract, of which 10 mg are ginsenosides; e) 150 mg of taurine; f) 100 mg of phosphatidylserine; g) 6 mg of vitamin B5; and h) 1.1 mg of thiamin. This dosage form includes the daily dose of the composition, i.e., the amount of the composition and its components that should be administered per day. It has been found that administering the product several times throughout the day led to an improved effect of the composition in the test subject. Consequently, in a particularly preferred embodiment, the dosage form, for example in the form of a capsule, lozenge, tablet, pill, or coated tablet as a dietary supplement, comprises at least one composition comprising: a) 75 mg to 150 mg of an omega-3 complex, preferably comprising 37.5 mg to 75 mg of EPA and DHA; b) 50 mg of Brahmi extract, comprising 22.5 mg of bacopasides; c) 50 mg of Ginkgo biloba extract, of which 1.5 mg are ginkgo flavonoids; d) 25 mg of Panax ginseng extract, of which 5 mg are ginsenosides; e) 75 mg of taurine; f) 50 mg of phosphatidylserine; g) 3 mg of vitamin B5; and h) 0.55 mg of thiamin. However, the daily dose of the composition can also be divided into any number of dosage forms, so that a higher number of capsules, lozenges, tablets, pills, dragees or other dosage forms can be used per day. In a preferred embodiment, the dosage form comprises a capsule or tablet. The dietary supplement in this dosage form should preferably be taken twice daily in order to reach the daily dose. Further literature concerning a known set of materials, processes and applications that can be used in accordance with the present invention is known to the person skilled in the art.

Claims

Composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg. Composition comprising: a) 150 mg to 300 mg of an omega-3 complex, comprising between 75 mg and 300 mg of EPA and DHA, preferably between 150 mg and 300 mg of EPA and DHA; b) 100 mg of Brahmi extract, comprising 45 mg of bacopasides; c) 100 mg of Ginkgo biloba extract, of which 3 mg are ginkgo flavonoids; d) 50 mg of Panax ginseng extract, of which 10 mg are ginsenosides; e) 150 mg of taurine; f) 100 mg of phosphatidylserine; g) 6 mg of vitamin B5; and h) 1.1 mg of thiamin. A dosage form comprising a composition according to claim 1 or 2, or comprising the following composition: a) 75 mg to 150 mg of an omega-3 complex, preferably comprising 37.5 mg to 75 mg EPA and DHA; b) 50 mg Brahmi extract, comprising 22.5 mg Bacopasides; c) 50 mg Ginkgo Biloba extract, of which 1.5 mg Ginkgo flavonoids; d) 25 mg Panax Ginseng extract, of which 5 mg Ginsenosides; e) 75 mg Taurine; f) 50 mg Phosphatidylserine; g) 3 mg Vitamin B5; and h) 0.55 mg Thiamin. Dosage form according to claim 3, wherein the dosage form is a capsule or tablet. Dosage form according to claim 4, wherein the capsule is a hard gelatin capsule, a soft gelatin capsule, an enteric-coated capsule, a hydroxypropylmethylcellulose (HPMC) capsule, a modified-release capsule and / or a film-coated capsule. Dosage form according to claims 3 to 5, wherein the dosage form comprises at least one additive. Dosage form according to claim 6, wherein the at least one additive comprises a filler, a disintegration accelerator, a dye, a film former and / or a thickening agent. Dosage form according to any one of claims 3 to 7, wherein the dosage form comprises at least one excipient, wherein the excipient is preferably sugar, binder, lubricant, oil, wax, gelatin, magnesium stearate, talc, carboxylpolymethylene, carboxylmethylcellulose, cellulose acetate phthalate and / or polyvinyl acetate. A dosage form comprising a composition according to claim 1 or 2, wherein the daily dose of the composition is distributed across one or more dosage forms. A composition according to claim 1 or 2, or a dosage form according to any one of claims 3 to 9 as a food supplement for maintaining and / or restoring mental performance and for stress reduction.