A triple prebiotic composition that promotes the absorption of calcium, magnesium, and zinc.

Abstract

A prebiotic composition to promote intestinal absorption, characterized in that the composition contains the following components: Fructooligosaccharides, galacto-oligosaccharides and polyglucose.

Description

Technical field

[0001] The present invention relates to a prebiotic composition containing fructooligosaccharides (FOS), galactooligosaccharides (GOS) and polydextrose to improve the low absorption rate of nutrients such as calcium, magnesium and zinc in the intestine, to optimize the intestinal environment, to maintain intestinal balance and to promote the absorption of substances. Background of the invention

[0002] The intestine is the core component of the human digestive system, connecting the stomach above to the anus below, and is primarily divided into two parts: the small intestine and the large intestine. The small intestine is the main site of nutrient absorption, and its inner wall is lined with finger-like, projecting villi and microvilli, allowing the effective absorption surface of the small intestine to expand to 200-300 square meters, thus creating a structural basis for efficient nutrient absorption. The large intestine is primarily responsible for the reabsorption of water and inorganic salts, as well as for the formation and storage of feces.

[0003] The key process of human nutrition occurs primarily in the small intestine, which is divided into the duodenum, jejunum, and ileau. The duodenum mainly receives digestive products from the stomach and mixes them with bile and natural substances to complete the further breakdown of fats, proteins, and carbohydrates. It is the main absorption site for iron, calcium, phosphorus, magnesium, and soluble lipid vitamins. The jejunum and ileau are responsible for the absorption of amino acids, glucose, fatty acids, vitamins, and minerals. The jejunum is primarily responsible for the absorption of most nutrients, while the ileau is mainly responsible for the absorption of bile salts and vitamins.

[0004] The degree of nutrient absorption through the intestine is closely related to development, growth, the immune system, and other aspects of the body.

[0005] Macronutrients include protein, fat, and carbohydrates. Protein malabsorption leads to a negative nitrogen balance, resulting in accelerated skeletal muscle breakdown, hypoprotein edema, impaired immune function, and delayed wound healing. Fat malabsorption not only causes energy loss and a deficiency of essential fatty acids but is also associated with reduced absorption of fat-soluble vitamins A, D, E, and K. Carbohydrate malabsorption causes osmotic diarrhea due to increased osmotic load, and unabsorbed components are fermented by bacteria after entering the colon, producing large amounts of gas and causing bloating. Furthermore, changes in colonic pH affect the composition of the bacterial flora and mineral absorption.

[0006] The effects of vitamin deficiencies are also widespread, with a deficiency of the fat-soluble vitamins A, D, E, and K leading to night blindness / dry eyes, rickets / osteomalasia, neuropathy / hemolytic anemia, and coagulation disorders. B vitamin deficiencies present in a variety of ways, from beriberi and pellagra to megaloblastic anemia and damage to the posterior spinal cord. Vitamin C deficiency causes the typical scurvy syndrome.

[0007] Micronutrients have a broad systemic impact on the body. Calcium deficiency primarily affects the skeleton (rickets, osteomalacia, osteoporosis), the neuromuscular system (tetany, increased neuromuscular excitability), and the cardiovascular system (QT prolongation, coagulation disorders). Magnesium deficiency can lead to muscle tremors, arrhythmias, untreatable hypokalemia, and insulin resistance, as it is a cofactor in more than 300 enzymatic reactions. Zinc deficiency manifests as hypogastric dermatitis, characteristic dermatitis, recurrent infections, hypogonadism, and growth retardation. Iron deficiency causes iron deficiency anemia, pica, anti-nail syndrome, and cognitive decline. Copper deficiency is relatively rare but can lead to neutropenia, neurological disorders, and bone fragility. Phosphorus deficiency affects energy metabolism and bone health, manifesting as bone pain, muscle weakness, and tissue hypoxia.

[0008] The absorption of these nutrients has a particularly profound impact on specific populations. If the gut microbiota is not well established, subsequent malabsorption of nutrients has more severe, validated consequences. Malabsorption in fetuses and infants can lead to intrauterine growth restriction, neurological deficits, and permanent impairment of mental development; children and adolescents exhibit growth retardation, reduced learning ability, and lower peak muscle mass; the elderly suffer from frailty syndromes, osteoporotic fractures, and accelerated cognitive decline; pregnant women are at risk for anemia of pregnancy, hypertension of pregnancy, and fetal growth restriction; and postoperative patients experience poor healing, leading to prolonged hospital stays and increased readmission rates.From a socioeconomic perspective, malabsorption leads to increased consumption of medical resources, reduced productivity, reduced quality of life, increased burden on healthcare providers, and long-term effects on child development.

[0009] The gut is home to a vast and diverse microbial community known as the gut microbiota. These symbiotic microorganisms play a key role in regulating nutrient metabolism, vitamin production, defending against pathogens, and maintaining immune homeostasis.

[0010] When the gut microbiome is out of balance, this can lead to a range of health problems. Impaired intestinal barrier function can allow endotoxins to enter the bloodstream, causing systemic, low-grade inflammation and insulin resistance. More importantly, disruptions in the structure and function of the gut flora can directly affect digestion and nutrient absorption efficiency. An imbalanced gut flora can lead to a decrease in beneficial bacteria such as bifidobacteria and lactobacillus, while an increase in conditionally pathogenic bacteria not only alters the gut's environmental pH but also significantly reduces the bioavailability of various minerals such as copper, iron, zinc, and magnesium. Probiotics, as beneficial microorganisms that colonize the gut, have been shown to have the potential to regulate nutrient absorption and alleviate deficiencies.

[0011] The short-chain fatty acids (acetic acid, propionic acid, butyric acid) produced by the fermentation of dietary fiber by gut flora can lower the pH in the intestinal lumen, convert insoluble calcium, magnesium, zinc, and other mineral salts (such as calcium phosphate and calcium phytate) into soluble ionic states, and thus improve their solubility. Simultaneously, short-chain fatty acids can upregulate the expression of the calcium-binding protein D9k and the transient receptor potential channel TRPV6 in intestinal epithelial cells, thereby promoting active calcium transport.

[0012] The gut microbiota participates in the dissociation and dehydration of primary bile acids to produce secondary bile acids (e.g., deoxycholic acid, lithocholic acid). Secondary bile acids have a stronger emulsifying capacity and promote the absorption of fat-soluble and fat-soluble vitamins A, D, E, and K. Furthermore, bile acids act as signaling molecules, activating the farnesol X receptor and the G-protein-coupled bile acid receptor TGR5, and regulating lipid and glucose metabolism.

[0013] What are the current solutions for symptoms of substance deficiency or absorption disorders?

[0014] The first is dietary and lifestyle intervention, multi-density supplementation for specific nutrients, and adjustments to diet and lifestyle; the second is precise oral nutrient supplementation for deficient vitamins or minerals; finally, if the situation is so severe that oral administration does not meet the body's needs, professional medical nutritional support and enteral or parenteral nutritional supplementation are required.

[0015] Traditional measures, however, have obvious limitations. The absorption rate of conventional calcium supplements is only 20% to 35%, and their absorption efficiency is affected by various factors such as stomach acid, time of ingestion, interaction with other food ingredients, and the solubility of the calcium source. At the same time, direct supplementation with high doses of inorganic salts can lead to gastrointestinal irritation such as bloating, constipation, or nausea, and excessive calcium supplementation not only improves absorption efficiency but also increases the risk of kidney stones. Therefore, maintaining and strengthening gut health, as well as optimizing the intestinal absorption environment, are key strategies for fundamentally improving nutrient deficiencies.

[0016] Significant progress has been made in the field of gut health in recent years. Alongside probiotics, prebiotics, as dietary components that selectively promote the growth of beneficial bacteria, have become an important means of regulating the gut microbiome. Studies have shown that prebiotics such as fructooligosaccharides, galacto-oligosaccharides, and polyglucose selectively stimulate the growth of beneficial bacteria like Bifidobacteria and Lactobacillus, lower the pH of the gut by producing short-chain fatty acids, and convert insoluble mineral salts into soluble ionic states, thereby promoting the absorption of divalent minerals such as calcium, magnesium, and zinc.At the same time, research on the interaction between trace elements and the gut microbiota reveals a two-way regulatory relationship: trace elements regulate the composition and function of the intestinal symbiotic bacteria, and the structure of the flora, in turn, influences the assimilation efficiency of these metal elements. This suggests that regulating the gut flora through precise prebiotic combinations could be an innovative method for improving mineral absorption efficiency.

[0017] However, most existing prebiotic compositions are designed for a single function, such as intestinal motility, and lack the ability to improve nutrient absorption, particularly for the systematic system that optimizes the uptake of minerals like calcium, magnesium, and zinc. How to synergistically improve the synchronous absorption efficiency of minerals through specific prebiotic compositions, while considering the overall health of the gut microbiome, has become a pressing technical challenge in this field.

[0018] Based on this technical requirement, the present invention develops a prebiotic composition with fructooligosaccharides, galacto-oligosaccharides and polyglucose, which aims to efficiently promote the absorption and utilization of nutrients such as calcium, magnesium and zinc by synergistically regulating the intestinal flora and compensating for the shortcomings of existing technologies and products. Description of the invention

[0019] The fundamental objective of the present invention is to provide an effective way to improve the internal environment of the intestinal microecology and to increase the absorption rate of nutrients such as calcium, magnesium and zinc, and the present invention achieves this objective through the embodiments described in the claims.

[0020] Therefore, according to the present invention, the composition of fructooligosaccharides, galacto-oligosaccharides and polyglucose can improve the intestinal environment and enhance the absorption of nutrients such as calcium, magnesium and zinc in the intestine.

[0021] In comparison to existing technology, it has been found that, according to the present invention, fructooligosaccharides, galacto-oligosaccharides and polyglucose can be used to improve the absorption of nutrients such as calcium, magnesium and zinc in the intestine.

[0022] US20220047659A1 includes the use of prebiotics (inulin) and a mixture of probiotics, roselle extract and other trace elements that work synergistically to reduce intestinal inflammation, promote nutrient absorption and improve health.

[0023] US20250302889A1 Includes the use of a formula combination of prebiotics (golden kiwi powder), probiotics (Bacillus coagulans) and postbiotics (inactivated Lactococcus lactis) to improve unwanted intestinal symptoms such as constipation, diarrhea, bloating, etc.

[0024] US20080261916A1 includes the formulation of various prebiotics, including fructooligosaccharides and galacto-oligosaccharides, which have a positive effect on intestinal health and improve the absorption environment.

[0025] US20260041722A1 includes the use of probiotics and prebiotics for the relief of menopausal symptoms in women and for the relief of musculoskeletal disorders such as osteoporosis, osteopenia and arthritis.

[0026] EP3454676B1 involves the use of one or more probiotics to increase the absorption and utilization of proteins in the body.

[0027] In the prior art literature, either the balance of the intestinal flora is related to or promotes the elimination of intestinal peristalsis, but no literature deals with the combination of fructooligosaccharides, galacto-oligosaccharides and polydextrose according to the present invention to improve the intestinal environment and promote the absorption of nutrients such as calcium, magnesium and zinc.

[0028] Fructooligosaccharides, also known as sucrose oligosaccharides or fructo-oligosaccharides, are a class of naturally occurring functional oligosaccharides that belong to the group of typical prebiotics. They are widespread in natural plants commonly consumed daily, such as bananas, rye, garlic, burdock, asparagus rhizomes, wheat, onions, potatoes, yacon, Jerusalem artichokes, honey, and others. Fructooligosaccharides have excellent physiological functions, including low calorie content, lowering of blood sugar, improvement of blood lipid levels, and promotion of trace element absorption. Commercially produced fructooligosaccharides are mainly obtained through two methods: one uses sucrose as a raw material and converts it into β-fructosidase or fructotransferase, which is produced by microorganisms such as Aspergillus niger; the other uses inulin as a raw material and employs enzymatic hydrolysis for production.Fructooligosaccharides have a sweetness of approximately 30% to 60% that of sucrose, high thermal stability, good solubility, moisture retention and low hygroscopy, and their main biological characteristic is that they are not hydrolyzed by the body's digestive enzymes, can reach the large intestine intact and are selectively used by the intestinal microbiota to exert a prebiotic effect.

[0029] Fructooligosaccharides (FOS) can regulate the gut microbiota, increase the abundance of beneficial bacteria, and improve the gut's ability to resist colonization by pathogens. Specifically, FOS can stimulate the proliferation of beneficial bacteria such as Bifidobacterium and Lactobacillus in the gut while inhibiting the growth of harmful bacteria. Numerous studies have shown that daily intake of a certain amount of FOS can increase the absorption of minerals and trace elements in animals and humans, particularly significantly improving the absorption rates of calcium, magnesium, and iron. Simultaneously, fructooligosaccharides contribute to the production of intestinal short-chain fatty acids, which can influence the expression of calcium-binding proteins and ion channels in intestinal epithelial cells and promote mineral transport.

[0030] Galacto-oligosaccharides (GOS) are heterosaccharides composed of galactose and glucose. They represent a class of naturally occurring functional oligosaccharides and are among the most studied and widely used prebiotics. Traces of GOS are found in animal milk, higher levels are present in human breast milk, and the establishment of bifidobacteria in infants largely depends on GOS in breast milk. Commercially produced galacto-oligosaccharides are primarily synthesized using microbially derived β-galactosidase in a highly concentrated lactose solution and via transglycosylation reactions. Galacto-oligosaccharides have a sweetness of approximately 20–40% of sucrose, strong moisture retention, acid and heat resistance, and high thermal stability under pH-neutral conditions.

[0031] Galacto-oligosaccharides are used as prebiotics to promote gut health, improve mineral absorption, regulate lipid metabolism, and strengthen the immune system. At the same time, galacto-oligosaccharides are an excellent source of nutrients and effective proliferation factors for beneficial bacteria such as Bifidobacterium and Lactobacillus acidophilus in the human gut, which can improve digestion and absorption. Since the digestive function of newborns is relatively weak, the nutrient components of galacto-oligosaccharides are added to infant formula.Studies have shown that galacto-oligosaccharides can increase the abundance of bifidobacteria in the gut and improve the body's absorption of calcium, and animal studies have also shown that GOS supplementation can significantly lower the pH of the gut, strengthen the intestinal barrier and increase the abundance of intestinal bifidobacteria, thereby improving the absorption and utilization of Ca and Mg as well as increasing mineral storage in bones, bone density and bone strength.

[0032] Polyglucose is a water-soluble dietary fiber belonging to the functional polysaccharides. It was invented in 1965 by Dr. Hans Rennhard and approved by the US FDA in 1981 after 16 years of research and development. Once in the human digestive system, polyglucose develops specific physiological and metabolic functions, playing a role in the prevention and treatment of constipation. Secondly, it also regulates lipid metabolism, lowers cholesterol, and reduces sugar absorption. Polyglucose is a type of D-glucose polymer composed of naturally occurring glucose and small amounts of sorbitol and citric acid, mixed and heated in a specific ratio to a molten mixture and then condensed under vacuum.

[0033] Polydextrose, an effective prebiotic and water-soluble dietary fiber, is not digested in the upper part of the gastrointestinal tract after ingestion. In the lower part of the gastrointestinal tract, it is fermented and utilized, promoting the growth of beneficial bacteria in the gut (Bifidobacterium, Lactobacillus) and inhibiting harmful bacteria (Clostridium, Bacteroidetes). The short-chain fatty acids produced during fermentation acidify the intestinal environment and increase the absorption of minerals such as calcium. Studies have long shown that polyglucose can significantly improve the absorption rate of calcium, magnesium, and zinc in the jejunum and has a positive impact on calcium bioavailability and the prevention of bone loss.

[0034] According to the present invention, the combination of three prebiotics, fructooligosaccharides, galacto-oligosaccharides and polyglucose, achieves a higher, more lasting and broader synergistic effect on the intestinal environment and the absorption rate of intestinal substances.

[0035] Numerous studies on prebiotics have shown the synergistic effect of fructooligosaccharides, galacto-oligosaccharides and polyglucose, which can improve the structure of intestinal microorganisms and have a positive effect on the absorption of intestinal substances.

[0036] Fructooligosaccharides and galacto-oligosaccharide prebiotic mixtures can increase the absorption and retention of calcium in the large intestine and bones, and regardless of the calcium content ingested, the intake of prebiotic mixtures can improve the absorption rate of minerals such as calcium, phosphorus, magnesium and other minerals in the large intestine, improve mineral content, bone density and bone parameters in the bones and promote bone development during adolescent growth.

[0037] Polyglucose and galacto-oligosaccharides were added to the infant formula to regulate the intestinal microbiota composition, promote the proliferation of bifidobacteria and stimulate the production of short-chain fatty acids, and infants showed good tolerance to the mixture of the two prebiotics.

[0038] Compared to fructooligosaccharides, polyglucose shows a slower fermentation rate, which also suggests that the combination of these two prebiotics may show a longer-lasting and more stable effect, helping to maintain a stable state of high uptake of environmental substances in the intestine.

[0039] The present invention relates to the improvement of the absorption rate of nutrients such as calcium, magnesium and zinc in connection with the improvement of intestinal microecology and the intestinal barrier, and furthermore with the adaptation of the intestinal health status.

[0040] When the body's intestinal health is abnormal, it means that the intestinal flora is disturbed, the intestinal barrier is damaged, and side effects such as bloating, diarrhea, abdominal cramps, and constipation can occur.

[0041] According to the present invention, the combination of fructooligosaccharides, galacto-oligosaccharides and polyglucose triple prebiotics serves to improve intestinal health by promoting the growth of beneficial bacteria, inhibiting the growth of harmful bacteria and strengthening the intestinal barrier.

[0042] According to the present invention, the combination of fructooligosaccharides, galacto-oligosaccharides and polyglucose triple prebiotics can also improve the absorption and utilization rate of nutrients such as calcium, magnesium and zinc in the intestine, enhance the nutrient effect of minerals, improve the retention of bone minerals and increase bone mass and bone density.

[0043] Therefore, the present invention includes the combination of fructooligosaccharides, galacto-oligosaccharides and polyglucose triple prebiotics to improve intestinal health, maintain the balance of intestinal microecology, strengthen the intestinal barrier, promote the absorption and utilization of nutrients such as calcium, magnesium and zinc, and promote bone growth.

[0044] The combination of fructooligosaccharides, galacto-oligosaccharides and polyglucose forms the basis of the present invention, and the dosage used is well known to engineers.

[0045] As is generally known in this field, the appropriate dosage depends on various factors, including age, weight, sex, etc., and dosage confirmation must be carried out with particular care in young children and adolescents. The dosage range described in the present invention is based on the weight and developmental needs of children over 6 months of age, as well as existing safety data, and the specific dose can be adjusted according to individual conditions under the guidance of a physician or nutritionist.

[0046] According to the present invention, in one embodiment the composition of fructooligosaccharides, galacto-oligosaccharides and polyglucose comprises the following weight of raw materials: The dosage of fructooligosaccharides is 1-70 parts; galacto-oligosaccharides should be used in 1-70 units; polyglucose is used in doses of 1 to 50 portions.

[0047] In another preferred implementation scheme according to the present invention, the composition of fructooligosaccharides, galacto-oligosaccharides and polyglucose comprises the following weight parts of the raw materials: 20-50 parts of fructooligosaccharides in dosage; galacto-oligosaccharides should be used in 15-55 parts; polydextrose is used in doses of 5-35 portions.

[0048] In another application of a more optimal scheme, according to the present invention, the composition of fructooligosaccharides, galacto-oligosaccharides and polyglucose comprises the following weights of raw materials: 30-40 parts of the fructooligosaccharides used; galacto-oligosaccharides should be used in 25-35 parts; polyglucose is used in doses of 10-20 portions.

[0049] In some embodiments of the present invention, the ratio of fructooligosaccharides, galacto-oligosaccharides to polyglucose by weight is (2-4) :(2-4) :(1-2).

[0050] In other embodiments of the present invention, the weight ratio of fructooligosaccharides to galacto-oligosaccharides is 1:5 to 5:1, the weight ratio of fructooligosaccharides to polyglucosaccharides is 1:3 to 10:1, and the weight ratio of galacto-oligosaccharides to polyglucose is 1:2 to 8:1.

[0051] According to the present invention, a combination of fructooligosaccharides, galacto-oligosaccharides and polyglucose is processed into any medically or food-acceptable dosage form, including, but not limited to: ① Solid dosage forms: powders, granules, capsules, tablets, solid drinks, block preparations; 2 Semi-solid dosage form: gels, meow, paste; ③ Liquid dosage form: oral liquid, mixture, syrup, emulsion, drops; ④ Carrier form: Tablets, sweets, dairy products, pastries, health food.

[0052] According to the present invention, all dosage forms consisting of a combination of fructooligosaccharides, galacto-oligosaccharides and polydextrosaccharides may be added to pharmaceuticals or foods as required, including, but not limited to, fillers, dispersants, binders, emulsifiers, stabilizers, flavor modifiers, etc.

[0053] The following is the preferred implementation scheme: According to the present invention, the preferred preparation of a combination of fructooligosaccharides, galacto-oligosaccharides and polyglucosaccharides comprises 30 parts of organic fructooligosaccharides, 30 parts of organic galacto-oligosaccharides and 20 parts of organic polyglucose, as well as further minerals, nutrients and excipients; the preferred form provided is an oral liquid dosage form, while the packaging form is a self-contained strip. Quotes included in the description

[0054] This list of documents prepared by the applicant is generated automatically and serves solely as a reader reference. The list is not part of the German Patent and Trademark Register. The utility model is applied. The DPMA assumes no responsibility for errors or omissions. Cited patent literature US20220047659A1

[0022] US20250302889A1

[0023] US20080261916A1

[0024] US20260041722A1

[0025] EP3454676B1

[0026] Zitierte Nicht-Patentliteratur Costa GT, Vasconcelos QDJS, Abreu GC, Albuquerque AO, Vilar JL, Aragão GF. Systematic review of the ingestion of fructooligosaccharides on the absorption of minerals and trace elements versus control groups. Clin Nutr ESPEN. 2021 Feb;41:68-76.

[0029] Whisner CM, Martin BR, Schoterman MH, Nakatsu CH, McCabe LD, McCabe GP, Wastney ME, van den Heuvel EG, Weaver CM. Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial. Br J Nutr. 2013, 110(7): 1292-303.

[0031] Weaver CM, Martin BR, Nakatsu CH, Armstrong AP, Clavijo A, McCabe LD, McCabe GP, Duignan S, Schoterman MH, van den Heuvel EG. Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation. J Agric Food Chem. 2011 Jun 22;59(12):6501-10.

[0031] Bei L, Wood RJ, Rosenberg IH. Glucose polymer increases jejunal calcium, magnesium, and zinc absorption in humans. Am J Clin Nutr. 1986 Aug;44(2):244-7.

[0033] Seijo M, Bonanno MN, Bryk G, Zeni Coronel ME, Pita Martin de Portela ML, Zeni SN. Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention? Calcif Tissue Int. 2022 Sep;111(3):300-312.

[0036] Borewicz K, Brück WM. Supplemented Infant Formula and Human Breast Milk Show Similar Patterns in Modulating Infant Microbiota Composition and Function In Vitro. Int J Mol Sci. 2024 Feb 2;25(3):1806.

[0037] Weisstaub AR, Abdala V, Gonzales Chaves M, Mandalunis P, Zuleta Á, Zeni S. Polydextrose Enhances Calcium Absorption and Bone Retention in Ovariectomized Rats. Int J Food Sci. 2013;2013:450794.

[0038] ZITATE ENTHALTEN IN DER BESCHREIBUNG

[0000] This list of documents cited by the applicant was automatically generated and is included solely for the reader's convenience. The list is not part of the German patent or utility model application. The DPMA accepts no liability for any errors or omissions. Cited patent literature

[0000] US 20220047659A1 [0022, 0054] US 20250302889A1 [0023, 0054] US 20080261916A1 [0024, 0054] US 20260041722A1 [0025, 0054] EP 3454676B1 [0026, 0054] Cited non-patent literature

[0000] Costa GT, Vasconcelos QDJS, Abreu GC, Albuquerque AO, Vilar JL, Aragão GF. Systematic review of the ingestion of fructooligosaccharides on the absorption of minerals and trace elements versus control groups. Clin Nutr ESPEN. 2021 Feb;41:68-76

[0054] Whisner CM, Martin BR, Schoterman MH, Nakatsu CH, McCabe LD, McCabe GP, Wastney ME, van den Heuvel EG, Weaver CM. Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial. Br J Nutr. 2013, 110(7): 1292-303

[0054] Weaver CM, Martin BR, Nakatsu CH, Armstrong AP, Clavijo A, McCabe LD, McCabe GP, Duignan S, Schoterman MH, van den Heuvel EG. Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation. J Agric Food Chem. 2011 Jun 22;59(12):6501-10

[0054] L, Wood RJ, Rosenberg IH. Glucose polymer increases jejunal calcium, magnesium, and zinc absorption in humans. Am J Clin Nutr. 1986 Aug;44(2):244-7

[0054] Seijo M, Bonanno MN, Bryk G, Zeni Coronel ME, Pita Martin de Portela ML, Zeni SN. Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention? Calcif Tissue Int. 2022 Sep;111(3):300-312

[0054] Borewicz K, Brück WM. Supplemented Infant Formula and Human Breast Milk Show Similar Patterns in Modulating Infant Microbiota Composition and Function In Vitro. Int J Mol Sci. 2024 Feb 2;25(3):1806

[0054] Weisstaub AR, Abdala V, Gonzales Chaves M, Mandalunis P, Zuleta Á, Zeni S. Polydextrose Enhances Calcium Absorption and Bone Retention in Ovariectomized Rats. Int J Food Sci. 2013;2013:450794

[0054]

Claims

[1] A prebiotic composition to promote intestinal absorption, characterized by , that the composition contains the following components: Fructooligosaccharides, galacto-oligosaccharides and polyglucose. [2] The prebiotic composition according to claim 1, wherein, in terms of parts by weight, the composition fulfills: Fructooligosaccharides 1-70 servings by weight; Galacto-oligosaccharides 1-70 by weight; Polydextrose 1-50 servings. [3] The prebiotic composition according to claim 2, wherein the composition in terms of parts by weight is as follows: Fructooligosaccharides 20-50 by weight; Galacto-oligosaccharides 15-55 by weight; Polyglucose 5-35 portions. [4] The prebiotic composition according to claim 3, wherein the composition, in terms of weight, comprises: Fructooligosaccharides 30-40 by weight; Galacto-oligosaccharides 25-35 by weight; Polydextrose 10-20 wt. [5] The prebiotic composition according to one of claims 1-4, wherein the ratio of fructooligosaccharides, galacto-oligosaccharides to polyglucose by weight is (2-4) :(2-4) :(1-2). [6] The prebiotic composition according to one of claims 1-4, wherein the weight ratio of fructooligosaccharides to galacto-oligosaccharides is 1:5 to 5:1, the weight ratio of fructooligosaccharides to polyglucose is 1:3 to 10:1 and the weight ratio of galacto-polyglucose is 1:2 to 8:

1. [7] The prebiotic composition according to any one of claims 1-4, wherein the average degree of polymerization of the fructooligosaccharides is 2-7 and the purity is ≥ 95%; the average degree of polymerization of the galacto-oligosaccharides is 2-8, and the purity is ≥ 90%; the average molecular weight of the polyglucose is 1000-5000, and the purity is ≥ 90%. [8] The prebiotic composition according to any one of claims 1-4, wherein the total content of fructooligosaccharides, galacto-oligosaccharides and polyglucose in the composition constitutes 30-95% of the total weight of the composition. [9] The prebiotic composition according to claim 8, wherein the total content of fructooligosaccharides, galacto-oligosaccharides and polyglucose in the composition constitutes 50% to 80% of the total weight of the composition. [10] The prebiotic composition according to one of claims 1-4, wherein the total addition of fructooligosaccharides and galacto-oligosaccharides does not exceed 64.5 g / kg and polydextrose is 15.6-31.25 g / kg when the composition is used in infant food. [11] The prebiotic composition according to any one of claims 1-4, wherein the composition is converted into a pharmaceutical or food-grade dosage form and the dosage form is selected from one of the following forms: Powders, granules, capsules, tablets, solid drinks, block preparations, gels, pastes, oral liquids, mixtures, syrups, emulsions, drops. [12] The prebiotic composition according to claim 11, wherein the tablet is selected from ordinary pressed tablets, chewable tablets, effervescent or dispersible tablets; the gelling agent is jelly or absorbent jelly. [13] The prebiotic composition according to claim 11, wherein the composition is processed into a solid drink and the solid drink is an instant powder or granules for drinking after mixing with water or dairy products. [14] The prebiotic composition according to claim 11, wherein the composition is processed into chewable tablets or gel candies suitable for direct chewing by children. [15] The prebiotic composition according to claim 11, wherein the composition is processed into an oral liquid or drops suitable for quantitative administration by infants and young children. [16] The prebiotic composition according to any one of claims 1-4, wherein the composition also includes food-grade or pharmaceutical-grade excipients and the excipients are selected from one or more fillers, anti-calcification agents, flavor corrections, stabilizers and preservatives. [17] The prebiotic composition according to claim 16, wherein the filler is selected from one or more maltodextrins, lactose, microcrystalline cellulose, sorbitol, erythritol; the anti-calcification agent is silicon dioxide; the odor corrector is selected from one or more citric acids, food flavorings and sweeteners. [18] A food, health food or drug used to promote intestinal absorption, wherein the food, health food or drug contains the prebiotic composition according to any one of claims 1-17. [19] The food, health product or drug according to claim 18, wherein the food is one of the following solid beverages, dairy products, baked goods, tablet candies and gel candies, wherein the health product consists of capsules, tablets, oral liquids and granules, and wherein the drug is an oral preparation.