TEMPERATURE CONTROL DEVICE FOR DERMAL APPLICATION

Description

[0001] The invention relates to temperature control devices which can be temporarily applied dermally to the human body.

[0002] Thermoelectric cooling is used in numerous fields of science and technology, particularly in medicine. Thermoelectric cooling can be used in practical applications such as cryosurgery, cryotherapy, neurosurgery, urology, plastic surgery, and dermatology. In dermatology, thermoelectric devices can be used to smooth wrinkles, strengthen parts of the human body, or improve well-being.

[0003] Cutaneous application and removal pads, also called "eye pads," are products from the cosmetics industry that are applied by a user to the area under and / or around the eyes to create a cosmetic effect on the skin. Cutaneous application pads, also called "philtrum pads," can also be used in the cutaneous area between the nose, nasolabial folds, and upper lip, the philtrum, to reduce wrinkle formation. Targeted cutaneous application of heat or cold can be an effective treatment, particularly against wrinkles.

[0004] Similarly, active temperature control devices can be used to cool a body region, such as a head region or an area of ​​the outer limbs, which devices comprise a thermally conductive skin contact material and a Peltier element that adjusts the temperature of the skin contact material.

[0005] Devices that heat and / or cool the skin under a user's eyes are known in the prior art. Traditionally, natural materials such as cucumber slices or similar are used for this purpose, which provide a cooling effect through dissipated evaporative heat. However, technical devices are also known that are applied to the skin and heat or cool the skin using electrical, chemical, or biochemical components.

[0006] Examples of this are described in the documents US 301,931 A, US 4,585,002 A, US 8,525,363 B1, US 2013 / 0172829 A1, US 9,849,024 B2, US 10,973,275 B2, US 2021 / 0127769 A1 or WO 2018 / 122710 A1.

[0007] The document US 2006 / 0168969 A1 discloses a thermoelectric device comprising a thermoelectric Peltier module, a heat sink on the hot side, a heat sink on the cold side and a temperature sensor such as a negative temperature coefficient thermistor (NTC) built directly into the thermoelectric module.

[0008] Document KR 2010-0028911 A discloses a cooling device comprising a thermoelectric module, a first thermistor attached to the cooling unit of the thermoelectric module, a second thermistor attached to the heat-generating part of the thermoelectric module, and a controller configured to control a drive current of the thermoelectric module based on temperatures measured by the first and second thermistors.

[0009] The document US 2018 / 0172325 A1 discloses a thermoelectric system comprising two spaced-apart substrates, electrically connected semiconductor elements in a gap between the two substrates, a sensor between the substrates, and a seal extending between the substrates and enclosing the sensor and at least one of the plurality of semiconductor elements.

[0010] The document JP H06-197924 A discloses a thermotherapeutic instrument which forms a recessed part on its surface side and has a heating element which releases heat in the therapeutic instrument and heats the underside of the recessed part.

[0011] The document CN 107 845 723 A discloses a thermoelectric device.

[0012] An object of the present invention is to provide an active temperature control device intended for dermal application for a defined heating or cooling of body regions.

[0013] According to one aspect of the invention, a temperature control device for dermal application comprises a particularly electrically non-conductive skin contact surface and at least one Peltier element connected to the skin contact surface. The skin contact surface can be formed, for example, by an electrically non-conductive thin film or an electrically non-conductive thin coating made of a suitable electrically non-conductive material, which is applied to one side of the Peltier element. The Peltier element has two parallel, spaced-apart insulation plates, between which doped semiconductor elements are inserted, through which electrical current can be conducted. Furthermore, the temperature control device has a temperature sensor, which is integrated in a recess of the Peltier element between the insulation plates and is connected to a temperature measuring circuit outside the Peltier element.

[0014] According to the invention, the temperature sensor comprises a circuit board and a negative temperature coefficient (NTC) sensor mounted on one side of the circuit board. According to the invention, the temperature sensor further comprises a clamp spring device mounted on a side of the circuit board facing away from the NTC sensor.

[0015] According to some embodiments of the temperature control device, the electrically non-conductive skin contact surface is a coating or foil on the outward-facing insulation plate of the Peltier element. In some embodiments, the coating or foil serves to mechanically protect the surface of the insulation plate of the Peltier element. The coating within the meaning of this application can be formed, for example, by applying a firmly adhering layer of amorphous material to the surface of the insulation plate of the Peltier element. The coating can consist of individual layers or several interconnected layers. The coating can be applied using a chemical, mechanical, thermal, and / or thermomechanical coating process.In this way, mechanical damage such as scratches or paint loss on the Peltier element can be avoided and / or corrosion protection can be increased.

[0016] According to a further development of the temperature control device, the coating or film is completely flat. According to a further development of the temperature control device, the coating comprises a ceramic material. In particular, the coating is designed as a ceramic lacquer, for example, Cerakote®< from NIC Industries, Oregon, USA. Alternatively or additionally, the coating comprises, for example, a substrate which, prior to the coating process, is in the form of a liquid, in particular a lacquer, or a solid, in particular a powder, laminate film, or similar film.

[0017] According to some embodiments of the temperature control device, the temperature control device further comprises a fixing device that fixes the Peltier element to a housing base. The fixing device is made, for example, from a glass-fiber-reinforced plastic. It can partially surround the Peltier element and be fastened to the housing base of the temperature control device. The fixing device can be fastened to the housing base by a detachable fastening means, in particular by a screw connection, a plug connection, or the like. In this way, the Peltier element can be pressed against the housing base under a predetermined contact pressure, creating a defined contact. The housing base can support all components of the temperature control device. Alternatively or additionally, the housing base can be made of a temperature-conducting material.This improves heat dissipation from the side of the Peltier element facing away from the skin contact surface to the environment when the skin contact surface corresponds to the cold side of the Peltier element, so that the unused heat from the warm side is not accumulated in the temperature control device. Thermal coupling between the housing base and the side of the Peltier element facing away from the skin contact surface can be achieved, for example, by surface contact. Additionally, a thermal paste, a thermal pad, or a similar thermally conductive material can fill any cavities in the surface contact, thus supporting heat transfer between the Peltier element and the housing base.

[0018] According to a further development of the temperature control device, the fixing device is designed to be so compact that, in an assembled state, it has a smaller distance in relation to the housing base than the skin contact surface is spaced from the housing base.

[0019] According to a further development of the temperature control device, the fixing device encloses the Peltier element between the insulation plates in a form-fitting manner, at least in sections.

[0020] According to some embodiments of the temperature control device, a control unit is connected to the temperature sensor and the Peltier element. The control unit is designed to regulate a heating or cooling output of the Peltier element based on a temperature of the Peltier element surface in the receiving area detected by the temperature sensor. Furthermore, the control unit can be designed to regulate the heating or cooling output of the Peltier element upon reaching a target temperature of the Peltier element surface in the receiving area such that the temperature of the Peltier element surface in the receiving area remains substantially constant. The Peltier element can be alternately supplied with or without electrical voltage, so that current flows through the Peltier element at times.The control unit, for example, switches an electrical circuit in which the Peltier element and a power source are integrated on or off depending on the detected temperature in comparison to the target temperature. Optionally, the control unit is further designed to take an ambient temperature measured by an ambient temperature sensor into account when controlling the heating or cooling output such that the heating or cooling output is increased, reduced, or prevented within predetermined temperature ranges of the ambient temperature. For example, in an environment whose temperature is higher than the target temperature, further heating of the skin contact surface can be prevented. Optionally, in an environment with an ambient temperature below normal room temperature, the heating output can be increased in order to compensate for the heat lost to the environment via the skin contact surface.

[0021] Preferred and alternative embodiments of the tempering device according to the invention are explained in more detail below with reference to the figures. Figure 1 shows a sectional side view of a tempering device with a completely flat coating according to an embodiment of the invention; Figure 2 shows a schematic representation of two Peltier elements, each with an integrated temperature sensor according to an embodiment of the invention; Figure 3 shows a schematic side view of a temperature sensor according to an embodiment of the invention in an uninstalled state; Figure 4 shows a sectional side view of a Peltier element with a temperature sensor integrated between the two insulation plates of the Peltier element according to an embodiment of the invention; Figure 5shows a schematic perspective view of a Peltier element with a fixing device which encloses the Peltier element between the two insulation plates in a form-fitting manner, at least in sections, according to an embodiment of the invention.

[0022] In Figure 1 shows a sectional side view of a temperature control device 21 with a completely flat coating. The temperature control device 21 is intended for temporary dermal application to the human body, for example, in the facial area or in the area of ​​the outer limbs such as upper arms, shoulders, calves, or the like, so that heat or cold generated by the temperature control device 21 can be transferred to the skin in the application area.

[0023] The temperature control device 21 has at least one Peltier element 22. A Peltier element 22 can be formed from a plurality of, for example, cuboidal or cylindrical semiconductor elements of different doping types, for example bismuth telluride or silicon germanium, which are sequentially coupled in alternating sequence on the top and bottom sides by electrically conductive interconnectors. The electrically conductive interconnectors form thermal contact surfaces and are embedded between two insulating plates, such as thin ceramic plates. When a predefined electrical current flows through the series connection of the alternating semiconductor elements, the interconnectors located on one insulating plate cool down depending on the current intensity and current direction, while the opposing semiconductor elements heat up accordingly.This creates a temperature difference between the insulation plates driven by the current flow.

[0024] Furthermore, the Peltier element 22 has, for example, a coating or foil 32 for mechanical and / or chemical protection of the Peltier element surface. The coating or foil 32 is, for example, designed as a laminate foil or ceramic coating. The coating or foil 32 is applied to the Fig. 1applied, for example, to the upwardly facing insulation plate 25 of the Peltier element 22. The Peltier element 22 is inserted into a receiving area 23 of a housing base 35. The receiving area 23 corresponds to a recessed area of ​​the housing base 35, the side walls of which are essentially flush with the upper insulation plate 25 of the Peltier element 22 at the upper edge. The coating or foil 32 spans the insulation plate 25 of the Peltier element 22 and extends beyond the insulation plate 25 of the Peltier element 22 to the upper edges of the side walls of the housing base 35, so that a circumferential gap between the upper insulation plate 25 of the Peltier element 22, which is flush with the housing base 35, and the side walls of the housing base 35 is sealed in a fluid-tight manner.This creates an electrically non-conductive skin contact surface 23 whose area is larger than the surface of the upper insulation plate 25 of the Peltier element 22. The fluid-tight sealing of the gaps at the skin contact surface 23 makes the contact surface on the skin more uniform and narrower. Furthermore, foreign matter such as sweat or sebum cannot penetrate the gap between the housing base 35 and the Peltier element 22, thus facilitating cleaning of the temperature control device 21, minimizing malfunctions, and improving the heating or cooling efficiency of the temperature control device 21.

[0025] By resorting to Fig. 1The temperature control device 21 can optionally have a rechargeable electrical energy storage device. The energy storage device is electrically connected at least to the Peltier element 22, but can also be electrically connected to other components of the temperature control device 21. The energy storage device can be, for example, a battery or an accumulator, which can be charged via a cable or wirelessly, in particular inductively, resonantly, or the like. Furthermore, the energy storage device can be permanently or replaceably integrated into the temperature control device 21.

[0026] The housing base 35 can accommodate or hold the Peltier element 22 and, if applicable, the electrical energy storage device. Furthermore, the housing base 35 can comprise a temperature-conducting material to absorb the waste heat from the Peltier element 22 and dissipate it into the environment. In this way, overheating of the temperature control device 21 can be reduced. Likewise, separate heat sinks can also be inserted into the bottom of the housing base 35 beneath the lower insulation plate 24. Furthermore, the housing base 35 can comprise a temperature sensor that measures the temperature of the base. Thus, the temperature of the base can be used as a reference value for the temperature of the Peltier element surface, for example, to throttle the Peltier element if the temperature of the base is too high, thus preventing overheating.

[0027] The temperature control device 21 can have a control unit 30. The control unit 30 is connected to the Peltier element 22 and the energy source in order to be able to control the Peltier element 22 and, in particular, its heating or cooling power. The control unit 30 is designed to monitor and control temperatures with which a body region is to be cooled. This allows for any desired cooling sequence; for example, it is possible to set interval cooling or cooling at a constant temperature.

[0028] Furthermore, the control unit 30 allows the specification of specific maximum and / or minimum temperature values, allowing a desired temperature range to be set for an individual treatment. This prevents, for example, an undesired drop below a minimum temperature. Furthermore, a patient can individually adjust any treatment temperature to their individual needs.

[0029] Temperature values ​​and / or temperature profiles are particularly preferably variably programmable or adjustable. Furthermore, external signals from the body, environment, and / or surroundings can be incorporated into a program sequence. The device or control unit 30 can also be designed to be adaptive. This allows bodily functions such as blood oxygen levels and / or skin resistance, as well as external signals such as light intensity, volume, and / or vibrations, to be monitored. Furthermore, the influence of the weather can also be monitored. Due to changes in temperature and / or air pressure, the probability of, for example, headaches or general physical well-being varies. The control unit 30 is expediently controlled to regulate specific cooling profiles via a mobile phone or the like, which is connected to the control unit via Bluetooth Low Energy, for example.The control unit 30 can have a control element for temperature adjustment and a rectifier for generating direct current. If multiple Peltier elements 22 are provided, it is expedient if they can be controlled individually or separately in order to enable different cooling curves for different body regions. In particular, the at least one Peltier element 22 is controlled with slow pulses of approximately 1 Hz, in particular approximately 0.7 Hz, particularly preferably approximately 0.5 Hz or less. However, the Peltier element 22 can also be controlled with a faster pulse frequency. Furthermore, it can be provided that the device or the control unit 30 can be controlled with an app via a mobile phone, a tablet PC, or the like. Such an app offers various curves or data for different complaints from which a patient or user can choose.

[0030] If a temperature is to be precisely regulated, it is further advantageous if at least one temperature sensor is provided. In particular, it is advantageous if several, for example six, temperature sensors are arranged at different locations on the device. The temperature sensors are preferably arranged close to the skin and on the cooling materials. In particular, the at least partially flexible circuit board comprises one or more temperature sensors. Furthermore, at least one temperature sensor can be designed to measure an ambient temperature. The circuit board can also comprise further electronic components, for example sensors for determining light intensity or bodily functions. Furthermore, it can be advantageous if actuator devices are provided, for example a vibration device for the mechanical stimulation of a part of the body to which the temperature control device 21 is applied.In addition, the vibration device can be used to notify users via haptic output signals, for example to inform the user about a certain usage time.

[0031] It may be advantageous if the control unit 30 has an acoustic output device. The acoustic output device can be configured to output various indicators such as warning signals and / or cooling progress to a patient or a treating physician.

[0032] In alternative embodiments of the temperature control device 21, two or more Peltier elements 22 can be provided, each of which is housed in its own receiving area 23. Furthermore, the control unit 30 can be provided for individually controlling the respective Peltier elements 22. The control unit 30 regulates the heating or cooling power of the various Peltier elements 22 based on the temperatures of the Peltier element surfaces in the respective receiving areas, as detected by various temperature sensors 31. Furthermore, when a target temperature of the Peltier element surface is reached, the control unit 30 can regulate the heating or cooling power of the Peltier elements 22 such that the temperature of the Peltier element surface is kept substantially constant.For example, it is also possible to significantly increase the heating power of the Peltier elements 22 for a certain period of time in a "boost" mode, for example at the beginning of a heating process, in order to shorten the waiting time until the target temperature is reached on the Peltier element surfaces.

[0033] Furthermore, the control unit 30 is designed to take into account an ambient temperature measured by an ambient temperature sensor when regulating the heating or cooling output. The control unit 30 increases, decreases, or prevents the heating or cooling output within predetermined temperature ranges of the ambient temperature. For example, in an environment whose temperature is higher than, for example, 55°C, further heating of the skin contact surface 23 can be prevented, since in this case, a malfunction or incorrect operation can be assumed. Alternatively or additionally, the control unit 30 is further designed to supply the heating or cooling output of the two or more Peltier elements 22 to only one of the Peltier elements 22 in phases. However, the present invention is not limited to the embodiment with one Peltier element 22, but can also have only some of the described features.Thus, a temperature control device 21 can be provided, for example, with two or more Peltier elements 22, wherein, for example, these are also operated independently of one another.

[0034] The control unit 30 preferably also has a communication interface configured to establish a data connection with a computer unit. The computer unit can be configured, for example, as a smartphone, server, or tablet computer, wherein the control unit 30 is configured to regulate the power of the Peltier element 22 based on data received from the computer unit via the communication interface.

[0035] The coating or foil 32 of the tempering device 21 extends in the example of Fig. 1beyond the receiving area of ​​the housing base 35 and at least partially also covers a support frame 33. A fixing device 34 is designed here, for example, as one or more screw connections, wherein the housing base 35 has corresponding threaded holes for fixing the screw connections. Furthermore, the fixing device 34 is designed such that the free space below the fixing device 34 and above the housing base 35 in the area of ​​the receiving area of ​​the housing base 35 for the Peltier element 22 has a lower height than the Peltier element 22 itself.

[0036] As a result, when the Peltier element 22 is inserted into this free space, pressure can be exerted on the Peltier element 22 by the fixing device 34, which presses the Peltier element 22 firmly against a heat sink located underneath and thus improves the thermal contact with the housing base 35 or the heat sink. As shown in Fig. 1As shown, the fixing device 34 consequently does not protrude beyond the upper edge of the side walls in the recessed area and thus not beyond the upper insulation plate 25 of the Peltier element 22.

[0037] The housing base 35 may include a support frame 33 extending around the upper edge of the housing base 35 below the skin contact surface 23. The support frame 33 may be an integral part of the housing base 35 or, alternatively, may be suitably attached to the housing frame as a separate component, for example, by a clip mechanism, screw connections, or adhesive.

[0038] Optionally, the fixing device 34 can have several additional components. Fig. 1 The fixing device 34 contains, for example, a clamping jaw and a mechanical transmission element. The transmission element is viewed in a normal direction of the insulation plates 24, 25 of the Peltier element 22 (in the Fig. 1The clamping jaw is mounted on the housing base 35, which presses the mechanical transmission element toward the base and thus presses the lower insulation plate 24, on which the transmission element rests, against the housing base 35.

[0039] As explained above, one or more temperature sensors 31 can preferably also be provided. A temperature sensor 31 can, for example, be provided between the Peltier element 22 and the coating 32. In particular, a temperature sensor 31 can be arranged at the edge of the receiving area 23. For example, a temperature sensor 31 can also be positioned on the coating 32 or in a recess in the coating 32.

[0040] In a special embodiment, the temperature sensor 31 can be embedded in the Peltier element 22. As in Fig. 2 As illustrated by way of example, the Peltier element 22 can be formed, for example, by two square or rectangular insulating plates made of ceramic aluminum oxide, spaced several millimeters apart, between which the semiconductor elements are soldered in a predetermined pattern. For this purpose, the pattern of the soldered semiconductor elements can form a recess at the edge of the Peltier element 22, which extends into the Peltier element 22 by a certain distance between the insulating plates 24 and 25.

[0041] Fig. 2shows a schematic representation of two Peltier elements 22, each with an integrated temperature sensor 31. The temperature sensor 31 can, for example, extend approximately to the geometric center of the Peltier element 22. Optionally, the temperature sensor 31 extends to approximately 1 / 3 or 1 / 4 of the length of the Peltier element 22. Two or more temperature sensors 31 can optionally be mechanically and / or electronically connected to one another by means of a web. Optionally, multiple temperature sensors 31 can be provided, which can be provided optionally in the previously mentioned positions or alternative positions.

[0042] Fig. 3 shows a schematic side view of a configuration of the Fig. 2usable temperature sensor 31 in an uninstalled state. The temperature sensor 31 comprises a circuit board 36 and a negative temperature coefficient (NTC) sensor 37 or thermistor or NTC resistor 37. The NTC sensor or NTC resistor 37 is preferably arranged in a front region of the circuit board 36, i.e., in a region of the tip of the circuit board 36. In this way, the NTC sensor or NTC resistor 37 can measure a temperature in a center of the Peltier element 22. Furthermore, the NTC sensor or NTC resistor 37 is preferably attached to a lower side of the circuit board 36. Nevertheless, it is not excluded that the NTC sensor or NTC resistor 37 is arranged on an upper or lateral side of the circuit board 36.

[0043] Optionally, the temperature sensor 31 can have several NTC sensors 37. In Fig. 3For example, two NTC sensors 37 are provided. Both NTC sensors 37 can be arranged on the same side, for example, to support more stable positioning. Instead of two NTC sensors 37, one NTC sensor 37 and a correspondingly mounted dummy sensor can also be used, whereby the dummy sensor is not used for temperature measurement.

[0044] In addition, the temperature sensor 31 comprises a clip spring device 38. This clip spring device 38 is attached to a side of the circuit board 36 facing away from the NTC sensor 37.

[0045] Fig. 4 shows a sectional side view of a Peltier element 22 with a temperature sensor 31 integrated between the insulation plates 24 and 25 of the Peltier element 22.

[0046] The temperature sensor 31 essentially has the features of the temperature sensor 31 in an uninstalled state according to the embodiment Fig. 3 According to the integrated, i.e. installed, state, the clamp spring device 38 of the temperature sensor 31 in the embodiment of the Fig. 4 subjected to a compressive stress. Thus, the clamp spring device 38 presses the circuit board 36 downward and consequently the NTC sensors 37 arranged on the side facing away from the clamp spring device 38 onto the insulation plate 24. Alternatively, the temperature sensor 31 can be integrated into the Peltier element 22 rotated by 180° with respect to its longitudinal axis. In this way, the temperature of the insulation plate 25, which corresponds to a receiving area of ​​the housing base 35, can be measured.

[0047] To integrate the temperature sensor 31, the recess at the edge of the Peltier element 22, which extends into the Peltier element 22 by a certain distance between the insulation plates 24 and 25, can be adapted in its volume to the dimensions of the temperature sensor 31, so that the temperature sensor 31 fits at least partially, in particular completely, into the recess. Optionally, the Peltier element 22 can have a coating 32 at least in sections, in particular in the receiving area 23.

[0048] Fig. 5 shows a schematic perspective view of a Peltier element 22 with a fixing device 34, which encloses the Peltier element 22 between the insulation plates 24 and 25 in a form-fitting manner, at least in sections.

[0049] The fixing device 34 is designed, for example, as a rectangular clasp with rounded corners, but is not limited to this shape. It can also be U-shaped, V-shaped, horseshoe-shaped, or the like. Furthermore, the fixing device 34 or a component of the fixing device 34 can be attached laterally to the Peltier element 22 in a manner that can be pushed, placed, clipped, or similarly. Optionally, the fixing device 34 encloses the Peltier element 22 at least in sections, for example, on two, three, or four lateral sides. The fixing device 34 can be designed in one piece or in multiple pieces.

[0050] Peltier elements as described herein by way of example are thermoelectric modules (TEM) that comprise thermoelectric semiconductor materials in pairs of different doping types (n-type and p-type). These thermoelectric semiconductor materials are embedded between two ceramic plates. Thermoelectric semiconductor materials commonly used in TEMs can include, for example, alloys of bismuth telluride (Bi 2 Te 3 ), lead telluride (PbTe), silicon germanium (SiGe), and bismuth antimony (BiSb). Bi 2 Te 3 is frequently used due to its unequal electron density. A typical TEM contains a structured array of semiconductor spheres, semiconductor pillars, or otherwise shaped semiconductor elements in pairs of different doping types (n-type and p-type), which are electrically coupled in series but thermally coupled in parallel.The structured arrangement extends in a planar extent between two mechanically stable insulation plates, usually made of ceramic materials such as aluminum nitride (AlN) and beryllium oxide (BeO) or ceramic Al 2 O 3 .

[0051] The TEM operates according to the principles of the Peltier effect. This means that when an electrical voltage is applied to two ends of a semiconductor material element, a temperature adjustment occurs. This leads to a temperature difference between the surfaces of the opposing, parallel insulating plates when a current flows through the series-connected semiconductor elements, so that one of the insulating plates is cooled and the other is heated.

[0052] To improve the temperature control of the thermoelectric module, an outwardly open recess is introduced into the structured arrangement of pairs of differently doped semiconductor elements in the planar extent, i.e., a cavity is formed between the insulation plates, the ceiling and floor of which are formed by the two insulation plates, and the lateral boundary walls of which are formed by the surrounding semiconductor elements. A temperature sensor can be introduced into this cavity, which has a carrier substrate, a thermistor applied to the carrier substrate, and electrical leads to the thermistor. The carrier substrate can, for example, be a printed circuit board (see element 36 in Fig. 4), on which a resistor with a negative temperature coefficient (NTC resistor) is applied as a thermistor on one side and a clamp spring device on the opposite side. The clamp spring device serves to exert compressive stress on the temperature sensor from the outside of the thermoelectric module when the temperature sensor's circuit board is inserted into the recess, ensuring that the temperature sensor is mechanically stable within the cavity.

Claims

1. Tempering device (21) for dermal application, having: a skin contact surface (23); at least one Peltier element (22) which is connected to the skin contact surface (23) and has two parallel insulation plates (24, 25) spaced apart from one another, between which doped semi-conductor elements are inserted, through which electric current can be conducted; and a temperature sensor (31), which is integrated in a recess of the Peltier element (22) between the insulation plates (24, 25) and is connected to a temperature measuring circuit outside of the Peltier element (22), and which has a printed circuit board (36) and a negative temperature coefficient sensor, NTC sensor (37), fitted to one side of the printed circuit board, characterised in that the temperature sensor (31) further has a clasp spring device (38), which is attached to one side of the printed circuit board (36) facing away from the NTC sensor (37).

2. Tempering device (21) according to claim 1, wherein the skin contact surface (23) is formed by an electrically nonconductive coating or film, in particular a ceramic coating or a laminate film, of the outwardly facing insulation plate (25) of the Peltier element (22) for mechanically protecting the Peltier element surface.

3. Tempering device (21) according to claim 1 or 2, further having: a housing base (35), in which the Peltier element (22) is received; and a fixing device (34), which fixes the Peltier element (22) to the housing base (35).

4. Tempering device (21) according to claim 3, wherein the fixing device (34) surrounds the Peltier element (22) between the insulation plates (24, 25) in a form-fitting manner at least in sections.

5. Tempering device (21) according to one of claims 1 to 4, further having a control unit (30), which is connected to the temperature sensor (31) and the Peltier element (22), wherein the control unit (30) is designed to regulate a heating or cooling capacity of the Peltier element (22) based on a temperature of the Peltier element (22) detected by the temperature sensor (31).