BIFIDOBACTERIUM LONGUM FOR THE TREATMENT OR PREVENTION OF MAJOR DEPRESSION

DE602016094709T2Active Publication Date: 2026-02-11SOCIETE DES PRODUITS NESTLE SA
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Patent Information

Application Number
DE602016094709
Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
Filing Date
2016-08-31
Publication Date
2026-02-11
Estimated Expiration
2036-08-31

AI Technical Summary

Technical Problem

Current antidepressant medications often come with significant side effects and require long-term therapy, making them costly and inconvenient for patients, while depressive symptoms not meeting the criteria for major depression are prevalent and poorly addressed.

Method used

Administration of Bifidobacterium longum ATCC BAA-999, a probiotic bacteria, which modulates gut-to-brain signaling to improve depressive symptoms and reduce brain emotional activity, offering a natural, side-effect-free alternative for treating and preventing depressive symptoms.

Benefits of technology

Bifidobacterium longum ATCC BAA-999 effectively improves depressive symptoms and quality of life by down-regulating brain areas involved in emotion control, providing prolonged benefits without the side effects associated with traditional antidepressants and reducing healthcare costs.

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Abstract

Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; "empty" feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof. These depressive symptoms can be associated with a depressive state or depressive disorder or can be found sub-clinically or not associated with these depressive states / disorders (e.g., not part of a syndrome or psychiatric disorder).
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