Compositions and methods for modulating the immune response by activating alpha-protein kinase 1
DE602018091753T2Active Publication Date: 2026-06-10SHANGHAI YAO YUAN BIOTECH CO LTD
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- SHANGHAI YAO YUAN BIOTECH CO LTD
- Filing Date
- 2018-10-25
- Publication Date
- 2026-06-10
AI Technical Summary
Technical Problem
There is a need for new methods to modulate inflammation in target tissues for treating diseases, disorders, and conditions resulting from inflammation and infections, as existing treatments are inadequate.
Method used
The use of ALPK1 agonists, such as HBP, HMP-1bP, and H1b-ADP, to activate the alpha-protein kinase 1 (ALPK1) kinase activity, either through small organic molecules or polynucleotides, to enhance immune responses and modulate inflammation.
Benefits of technology
Activating ALPK1 leads to increased expression of cytokines and enhanced immune responses, effectively inhibiting tumor growth and modulating inflammation, as demonstrated in mouse models.
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