METHOD FOR PRODUCING A TETRACYCLICAL COMPOUND
Patent Information
- Application Number
- DE602019065213
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2019-09-03
- Publication Date
- 2025-01-22
- Estimated Expiration
- 2039-09-03
AI Technical Summary
The existing method for manufacturing Compound (1) faces challenges such as environmental impact, safety concerns due to solvent use, and the formation of by-products and regioisomers, necessitating an improved and industrially preferable method.
A manufacturing method for Compound (1) involving a series of steps using specific solvents like dichloromethane, 1,4-dioxane, and condensing agents like N,N'-diisopropylcarbodiimide, which avoids the use of substances of very high concern and enhances reaction selectivity, reducing by-product formation.
The method provides a simple, efficient, and robust process for manufacturing Compound (1) with high yield, improved safety, and reduced environmental impact, while effectively controlling impurity levels and maintaining pharmacological properties.