DETECTION OF MYCOBACTERIUM SPECIES
Patent Information
- Application Number
- DE602020057488
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-09-23
- Filing Date
- 2020-09-23
- Publication Date
- 2025-08-27
- Estimated Expiration
- 2040-09-23
AI Technical Summary
Current methods for detecting viable Mycobacterium species, such as Mycobacterium avium complex and Mycobacterium tuberculosis, are labor-intensive, costly, and difficult to scale up for high-throughput analysis, and struggle to differentiate between live and dead cells, which is crucial for accurate disease diagnosis and food safety.
A phage-based method using mycobacteriophage-coupled paramagnetic particles for selective capture and lysis of viable Mycobacterium species, followed by nucleic acid analysis to identify specific sequences, allowing rapid and reliable detection in a single-tube format.
Enables rapid, cost-effective, and high-throughput detection of viable Mycobacterium species, distinguishing between infected and vaccinated individuals, and differentiating between live and dead cells, with results obtainable within 24 hours.