Composition comprising coral mucus and use thereof

Abstract

The invention relates to a composition comprising mucus from at least one coral and to the use thereof in a cosmetic composition or dietary supplement, to a composition comprising coral mucus for therapeutic applications, and to a method for obtaining mucus from at least one coral, which method comprises a step of collecting the mucus by gravity and suction collection methods. The present invention relates to the field of natural products for the cosmetic industry sector, the dietary supplement sector or the pharmaceutical sector. More specifically, the invention relates to the use of coral mucus in these sectors and more specifically to the formulation of cosmetic compositions or natural dietary supplements.

Description

[0001] “Composition comprising coral mucus, and its use”

[0002] TECHNICAL FIELD

[0003] The present invention relates to the field of natural products for the cosmetics and well-being industry.

[0004] The field of the invention relates more particularly to the use of coral mucus in these fields and more specifically for the formulation of therapeutic or cosmetic compositions or natural food supplements.

[0005] STATE OF THE ART

[0006] Corals are organisms whose cellular and molecular physiology is still relatively unknown and which live individually for up to several decades. They survive over long periods, although constantly exposed to bacterial, viral, and fungal attacks, but also to environmental hazards such as climate or pollution; many opportunistic or specialized parasitic or predatory organisms also constitute a nuisance. The resistance of corals to all of these harmful effects therefore foreshadows a potential source of new natural molecules with interesting effects in the fields of cosmetics, dermatology, well-being, or pharmaceuticals.

[0007] Mucus is a viscous substance often created by living organisms. This surface layer, which covers the skin of many marine animals, acts as a protective barrier against external threats.

[0008] Coral produces mucus, among other things. It is the coral ectoderm that secretes mucus. Mucus is defined as a mixture of proteins and carbohydrates. This constitutes a very fine mesh and can be used in the same way as a "fishing net." It can trap food particles and zooplankton elements. Once stuck in this net, these elements are brought to the mouth by ciliary movements or by the tentacles. Corals are currently under close scrutiny in light of climate change, which is leading to their bleaching and a reduction in their population.

[0009] We know of document KR 20140066521, which concerns fish and the use of their mucus. Fish are aquatic vertebrate animals that are very different from corals, which are invertebrate animals.

[0010] The publication XP35127195 "Antibacterial activity of pseudoalterominas in the Coral Holobiont" focuses on the antibacterial effect of a family of Pseudoalterominas bacteria identified in the mucus of the corals Platygyra sp, Porites sp, Stylophora sp. and Pocillopora sp and concludes that this family of bacteria should play a role in protecting corals against gram-positive bacteria pathogenic to corals.

[0011] Publication XP93038660 "Coral Mucus is a hot spot for viral infection" concerns the assessment of the spread of pathogenic viruses in corals and concludes that coral mucus represents a highly favorable habitat for viral proliferation.

[0012] Document US2018 / 318205 describes the use of red algae in cosmetics. Red algae, despite their English name "slender beaded coral weed," are plants and not corals.

[0013] The present invention aims to provide a composition comprising coral mucus and its use.

[0014] Other objects, features, and advantages of the present invention will become apparent from the following description and accompanying drawings. It is understood that other advantages may be incorporated.

[0015] SUMMARY

[0016] To achieve this objective, the invention relates, according to one embodiment, to a composition comprising, advantageously all or part, of the mucus derived from at least one coral, and advantageously an excipient or vehicle suitable for subcutaneous application or for oral administration or topical administration.

[0017] According to another aspect, the invention relates to a food supplement comprising mucus from at least one coral or comprising the composition comprising mucus from at least one coral.

[0018] According to another aspect, the invention relates to a cosmetic composition comprising mucus from at least one coral.

[0019] According to another aspect, the invention relates to the cosmetic use of coral mucus, advantageously of all or part of the coral mucus.

[0020] According to another aspect, the invention relates to the use of the cosmetic composition or the food supplement.

[0021] According to another aspect, the invention relates to a composition comprising mucus from at least one coral intended for therapeutic application. According to another aspect, the invention relates to a method for obtaining mucus from at least one coral.

[0022] DETAILED DESCRIPTION

[0023] Before commencing a detailed review of embodiments of the invention, optional features which may possibly be used in combination or alternatively are set out below:

[0024] In one example, the composition comprises mucus from at least one coral.

[0025] In one example, the at least one coral is selected from soft mucus-producing corals or hard mucus-producing corals.

[0026] According to one example, the mucus, advantageously all or part, is in the viscous state or in the dry state. According to one aspect, the invention relates to a cosmetic and non-therapeutic composition comprising mucus from at least one coral.

[0027] In one example, the cosmetic and non-therapeutic composition is configured to be in the form of a shampoo, a mask, a soap, a gel, a cream, a lotion, a balm, a spray, a toothpaste.

[0028] According to one example, the cosmetic use of coral mucus, advantageously all or part of the coral mucus, in form, is suitable for topical application to the skin, mucous membranes or appendages.

[0029] According to one example, the cosmetic use of coral mucus, advantageously all or part of the coral mucus in form, is adapted in the form of a shampoo, for example liquid or solid, a soap, a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste for example soft or hard paste.

[0030] In one aspect, the invention relates to a body hygiene product or a cosmetic care product comprising coral mucus, advantageously all or part of the coral mucus. In one aspect, the invention relates to a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste comprising coral mucus, advantageously all or part of the coral mucus.

[0031] According to one aspect, the invention relates to the use of the cosmetic and non-therapeutic composition for:

[0032] - hydration of the skin or mucous membranes or appendages,

[0033] - fight against skin aging,

[0034] - fight against skin imperfections, for example spots and excess sebum, for example acne,

[0035] - reduction of wrinkles and fine lines,

[0036] - fight against the loss of skin elasticity,

[0037] - combat the loss of shine, luminosity or radiance of the skin,

[0038] - reduce pore dilation,

[0039] - reduce the thickening of the surface layer of the skin,

[0040] - combat color changes or irregularities in pigmentation, abnormal and / or excessive keratinization of the skin, - a thermoprotective effect,

[0041] - protection of the skin barrier,

[0042] - maintenance and protection of the skin microbiota,

[0043] - cell renewal,

[0044] - skin firmness.

[0045] According to one aspect, the invention relates to the use by topical application to the skin, mucous membranes or appendages of the cosmetic and non-therapeutic composition.

[0046] In one aspect, the invention relates to a dietary supplement comprising the composition.

[0047] In one example, the dietary supplement is configured to be in the form of a dose, a capsule, a lozenge, a tablet, a pill, a sachet of powder, an ampoule of liquid, or a bottle with a dropper.

[0048] According to one aspect, the invention relates to the use of the food supplement for

[0049] - hydration of the skin or mucous membranes or appendages,

[0050] - fight against skin aging,

[0051] - reduction of wrinkles and fine lines,

[0052] - fight against the loss of skin elasticity,

[0053] - combat the loss of shine, luminosity or radiance of the skin,

[0054] - reduce pore dilation,

[0055] - reduce the thickening of the surface layer of the skin,

[0056] - combat color changes or irregularities in pigmentation, abnormal and / or excessive keratinization of the skin,

[0057] - protection of the skin barrier,

[0058] - maintenance and protection of the digestive or cutaneous microbiota

[0059] - Improve intestinal and digestive comfort,

[0060] - Promote weight loss,

[0061] - Reduce heartburn, burning, heaviness, constipation or bloating,

[0062] - Improve, maintain and protect the digestive microbiota,

[0063] - Promote cell renewal,

[0064] - Skin firmness.

[0065] In one aspect, the invention relates to the use of the dietary supplement by oral application of the dietary supplement.

[0066] According to one aspect, the invention relates to a composition intended for therapeutic application for:

[0067] - An anti-inflammatory effect

[0068] - An antibacterial effect

[0069] - An antiviral effect

[0070] - An antioxidant effect,

[0071] - Acne treatment,

[0072] - Treatment of eczema,

[0073] - Skin photoprotection, According to one aspect, the invention relates to a method for obtaining mucus from at least one coral comprising a step of recovering the mucus by suction or by gravity.

[0074] A parameter "substantially equal / greater / less than" or "of the order of" a given value means that this parameter is equal / greater / less than the given value, to within plus or minus 10%, or even plus or minus 5%, of this value.

[0075] Mucus is a gelatinous, watery, or viscous liquid. Coral mucus is a complex mixture of organic matter composed primarily of carbohydrates (mainly polysaccharides) and proteins, but also lipids, which is produced by mucocytes in the coral epidermal layer of the ectoderm on the surface of the coral.

[0076] Coral is a living organism of the class Anthozoa (within the phylum Cnidaria), characterized by a calcareous (hard) or proteinaceous (soft) exoskeleton. Corals are invertebrate animals.

[0077] The term "coral mucus" or "mucus from at least one coral" means mucus or a mixture of mucus. Preferably, the coral mucus according to the invention is either in the raw state, i.e. unmodified following its collection, with the exception of a sterilization treatment, in which case the mucus is in a more or less liquid state commonly referred to as a viscous state, or in the dried or freeze-dried state, i.e. unmodified with the exception of its dehydration, in which case the mucus is preferably in a powder state. Coral mucus is also understood to be in a solid form below its solidification temperature. By way of example, the invention applies to frozen coral mucus.

[0078] The term "anti-aging" means an effect intended to combat superficial aging of the skin such as, for example, flaccidity, sagging, wrinkles and fine lines, dryness, dehydration, loss of skin elasticity, loss of shine, luminosity and radiance of the skin, dilation of pores, thickening of the surface layer, changes in color or irregularities in pigmentation, abnormal and / or excessive keratinization of the skin.

[0079] A "moisturizer" is a product that hydrates the skin and the surface layer of the epidermis and prevents its dehydration by restoring the hydrolipidic film, the skin's natural protection and all the properties that result from it.

[0080] The term "UV protection" or "photoprotection" refers to the various means capable of counteracting skin damage caused by solar radiation.

[0081] "Solar radiation" means the radiation emitted by the sun and reaching the Earth's surface, in particular UV-A and UV-B rays, but also infrared rays which cause the skin to heat up.

[0082] A "probiotic" effect means protecting the skin or digestive microbiota (or flora) from external aggressions. When pathogenic bacteria try to establish themselves, probiotics, which are living microscopic organisms (yeasts, viruses, bacteria, etc.), produce toxic substances to destroy them.

[0083] A "thermoprotective" effect, for hair cosmetics, is understood to mean protection against heat caused, for example, by a hairdryer or curling iron. By "cosmetically acceptable", or "suitable for "cosmetic use" is meant compatible with the skin and / or mucous membranes and / or appendages, which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), likely to discourage the consumer from using this composition.

[0084] A "food supplement" means a product as defined in Directive 2002 / 46 / EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States relating to food supplements. A "food supplement" means a foodstuff intended to supplement the normal diet and which constitutes a concentrated source of nutrients or other substances having a nutritional or physiological effect alone or in combination.

[0085] The invention relates to a composition comprising mucus from at least one coral.

[0086] Mucus is mucus from a single coral or a mixture of mucus from several corals. According to the invention, the mucus is either in a viscous state or in a dry state, for example in powder form. The mucus is advantageously raw mucus, i.e. unmodified, also called native, except for a sterilization and / or freeze-drying or dehydration treatment.

[0087] According to one possibility, mucus is understood to be all or part of the mucus. The mucus having been enriched or not. According to one possibility, the mucus includes adapted concentrations of the different components.

[0088] According to one possibility of the invention, the at least one coral is chosen from among the hard corals of the Acropora family Acropora yongei, Porites, Hermatypic, Porites astreoides, Diploria strigosa, Montastrea annularis, Colpophyllia natans, Acropora palmata, Lobophyllia hemprichii, Fungia scutaria, Fungia repanda, Acropora danai, Pocillopora eydouxi, Pocillopora meandrian, Fungia fungites, Fungia repanda, Diaseris distorta, Fungia scutaria, Cycloseris costulata, Cycloseris doederleini, Cycloseris marginata, Fungia actiniformis, Fungia danai, Fungia echinata, Fungia fungites, Fungia granulosa, Fungia horridae, Fungia Klunzingeri, Fungia scruposa, Fungia sommmervillei, Platigyra sp., M. annularis, P. astreoides, F. scutaria, Palythoa sp., F. scutaria, Acropora spp., Montipora digitata, Euphyllia sp., Porites porites, Porites compressa, Acropora sp., Siderastrea siderea, Agaricia agaricites, Madracis mirabilis, Montastrea cavernosa, P.porites, Eusmilia fastigiata, Mussa angulosa, Favia fragum, Colpophyllia natans, D. strigosa, Cladocoral cespitosa, Mycetophyllia reesi.

[0089] According to another possibility of the invention, the at least one coral is chosen from soft corals chosen from Sarcophyton sp., Lemnalia sp., Cespitularia sp., Rumphella aggregata, coelenterates of the Red Sea, Lobophyton sp, Rhytisma fulvum fulvum and Xenia sp.

[0090] According to one possibility, the composition consists solely of mucus from at least one coral.

[0091] According to one embodiment, the composition comprises at least one excipient or vehicle suitable for subcutaneous application.

[0092] According to one embodiment, the composition comprises at least one excipient or vehicle suitable for topical application. According to one embodiment, the composition comprises at least one excipient or vehicle suitable for oral administration.

[0093] According to one possibility, the composition comprises at least one cosmetically acceptable excipient or vehicle. The composition is a cosmetic, non-therapeutic composition, that is to say that the cosmetic composition is a composition suitable for a cosmetic application.

[0094] The cosmetic composition is advantageously intended for topical application. The cosmetic composition preferably has a form suitable for topical or subcutaneous application. Preferably, the cosmetic composition is intended and advantageously suitable for application to the skin including the lips, hair, eyelashes, eyebrows and / or nails. The cosmetic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray.

[0095] The cosmetic composition is advantageously intended to be used for moisturizing the skin, mucous membranes or appendages, combating skin aging, reducing wrinkles and fine lines, combating loss of skin elasticity, combating loss of shine, luminosity or radiance of the skin, reducing pore dilation, reducing thickening of the surface layer of the skin, combating changes in color or irregularities in pigmentation, abnormal and / or excessive keratinization of the skin, protecting the skin barrier, improving, maintaining and protecting the skin microbiota, heat protection of the hair, promoting cell renewal, particularly of the skin, improving skin firmness.

[0096] According to one possibility, the composition comprises at least one excipient or vehicle configured to be used as a dietary supplement. The invention relates, according to one aspect, to a dietary supplement comprising mucus from at least one coral or a composition comprising mucus from at least one coral as described above.

[0097] The food supplement is advantageously intended for oral administration. The food supplement preferably has a form suitable for oral administration such as, for example, a liquid or pseudo-liquid such as viscous, i.e. in the form of a syrup, gel, spray, ampoule, capsule, bottle equipped with a dropper or such as, for example, in the form of a solid dose such as a capsule, a gel cap, a lozenge, a tablet, a pill, a tablet, a sachet of powder. Other similar forms of liquid or powder preparations intended to be taken in measured units may be used.

[0098] Advantageously, the food supplement is intended to be used in dose form.

[0099] According to one embodiment, the food supplement is intended to be used daily in the form of a dose, 1 to 3 times per day, for example in the morning, at noon and / or in the evening.

[0100] The food supplement is advantageously intended to be used for the hydration of the skin, mucous membranes or appendages, to combat skin aging, the reduction of wrinkles and fine lines, to combat the loss of skin elasticity, to combat the loss of shine, luminosity or radiance of the skin, to reduce the dilation of pores, to reduce the thickening of the surface layer of the skin, to combat changes in color or irregularities in pigmentation, abnormal and / or excessive keratinization of the skin, to protect the skin barrier, to improve firmness, to improve, maintain and protect the digestive or skin microbiota, to improve intestinal and digestive comfort, to promote weight loss or to reduce heartburn, burning, heaviness, constipation or bloating.

[0101] According to one possibility, the composition comprises at least one pharmaceutically acceptable excipient or carrier. The composition is a therapeutic composition, that is, the composition is a composition suitable for a therapeutic application.

[0102] The invention relates to this purpose to a composition comprising mucus from at least one coral intended for therapeutic application. The therapeutic composition is advantageously intended for topical or subcutaneous application or by oral administration. The therapeutic composition preferably has a form suitable for topical or subcutaneous or oral application. Preferably, the therapeutic composition is intended and advantageously suitable for application to the skin including the lips, hair, eyelashes, eyebrows and / or nails. The therapeutic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray.The therapeutic composition is also suitable for oral administration, for example, in the form of a syrup, gel, spray, ampoule, capsule, bottle with a dropper, or for example in the form of a solid dose such as a capsule, a gel cap, a lozenge, a tablet, a pill, a cachet, a sachet of powder. The cosmetic composition is also suitable for subcutaneous administration, for example by injection. The composition is advantageously intended to be used for therapeutic application for an anti-inflammatory effect, an antibacterial effect, an antiviral effect, an acne treatment, an eczema treatment, skin photoprotection, an antioxidant effect, or cell repair.

[0103] For example, the amount of mucus in cosmetic applications is between 0.5% and 50% by weight of the total weight of the final composition.

[0104] For example, the amount of mucus in therapeutic applications is between 50.5% and 100% by weight of the total weight of the final composition.

[0105] For example, the amount of mucus in dietary supplement applications is between 0.5% and 100% by weight of the total weight of the final composition.

[0106] According to another aspect, the invention relates to a method for obtaining mucus from at least one coral. The method according to the invention comprises a step of recovering the mucus advantageously without damaging the coral. The coral is not destroyed, is not cut. The coral remains intact. The method according to the invention is non-invasive.

[0107] In a preferred embodiment, the collection step is performed by suction of the mucus or by gravity. Specifically, the coral is turned over to collect the mucus by gravity or the mucus can also be collected with a syringe by suction.

[0108] According to one possibility, the method comprises a step preliminary to the recovery step which is a step of removing the coral from the water.

[0109] According to one possibility, the method comprises a step subsequent to the step of removing the coral from the water which is a step of removing excess water, more precisely the coral is sponged.

[0110] According to one possibility, the method comprises a step of stimulating the production of mucus before the recovery step and preferably after the step of removing the coral from the water and preferably after the step of removing excess water. For example, the step of stimulating the production of mucus is carried out by contact with air and / or by stirring with a glass rod.

[0111] Advantageously, the method according to the invention comprises a step of sterilizing the mucus. Preferably, the sterilization step is carried out by exposing the mucus for a predefined time to UV radiation, for example a UV lamp. This step makes it possible to eliminate microorganisms, preferably viruses and parasites, from the mucus without degrading the primary structure of the mucus.

[0112] For example, sterilization is achieved by exposing the mucus to a UV lamp for a predefined time, for example, around two hours in an Eppendorf® tube, or by irradiation with gamma photons for a predefined time. Alternatively, the tube is then closed and placed in a paper cryobox. The entire box is then treated with gamma photons at a dose of 25 to 50 kGy using a standard commercial process.

[0113] Advantageously, the method according to the invention comprises a step of antibiotic treatment of the mucus. The mucus is subjected to at least one antibiotic or one or more antibiotics selected to destroy certain bacteria and preserve others. This step is particularly useful in the case of use as a probiotic.

[0114] Preferably, the cosmetic composition and / or the food supplement are formulated from natural ingredients.

[0115] According to one possibility, the invention relates to a method comprising the cosmetic application of coral mucus, advantageously all or part of the coral mucus. Preferably, the cosmetic application comprises a topical application. Preferably, the cosmetic application comprises application to the skin including the lips, hair, eyelashes, eyebrows and / or nails. According to one possibility, the method comprises the cosmetic application of a composition comprising coral mucus.

[0116] Example 1 - cosmetic composition for a cream, lotion or gel:

[0117] Coral Mucus, Water, Organic Glycerin, Organic Butyrospermum Parkii (Shea Butter), Organic Coco Nucifera (Coconut) Oil, Organic Sim-mondsia Chinensis (Jojoba) Seed Oil, Cetearyl Olivate, Sorbitan Olivate, Cassia Angustifolia Seed Polysaccharide, Alteromonas Ferment Extract, Jojoba Esters, Seed Wax, Polyglycerin-3, Beta-Glucan, Algin, Xanthan Gum, Organic Cedrus Atlantica (Cedarwood) Bark Oil and Salvia Officinalis (Sage) Oil, Vitamin E. 2 - a cream, lotion or qel:

[0118] Coral Mucus, Water, Caprylic / Capric Triglyceride, Squalane (Olive), Dipalmitoyl Hydroxyproline, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Helianthus Annuus (Sunflower) Seed Oil, Alkyl Glucoside, Glyceryl Stearate, Stearic Acid,

[0119] Leuconostoc / Radish Root Ferment Fil-trate, Hydroxyethylcellulose, Persea Gratissima (Avocado) Oil, Sim-mondsia Chinensis (Jojoba) Seed Oil, Capryloyl Glycine, Undecy-lenoyl Glycine, Glycine, Calendula Officinalis Flower Extract.

[0120] Example 3 - food supplement in the form of a capsule to be taken daily:

[0121] - Coral Mucus (280 mg per 1 capsule) - Anti-caking agent: vegetable magnesium stearate

[0122] - Gelatin envelope: natural chlorophyll Example 4 - mucus recovery process

[0123] The chosen coral is Acropora yongei. The coral is removed from the aquarium. The coral is advantageously turned over and preferably exposed to air for a predefined time, for example 10 seconds advantageously to reduce coral stress. The mucus is then collected directly into a glass tube or Falcon®.

[0124] 5 - Mucus recovery process

[0125] The chosen coral is Acropora yongei. The coral is removed from the aquarium. The coral is advantageously turned over and preferably exposed to air and mechanically stimulated for a predefined time, for example 5 seconds advantageously to reduce coral stress. Mechanical stimulation is carried out by a rod, preferably made of glass, which is slid along the coral. The mucus is then collected directly into a glass or Falcon® tube.

[0126] Example 6 - Mucus recovery process

[0127] The chosen coral is Acropora yongei. The coral is kept in the aquarium. The coral is mechanically stimulated for a predetermined time, for example 5 seconds, advantageously to reduce coral stress. Mechanical stimulation is achieved by sliding a rod, preferably made of glass, along the coral or by jets of water. The mucus is then collected with a pipette.

[0128] The invention is not limited to the embodiments previously described and extends to all embodiments covered by the invention.

Claims

Claims 1. Composition comprising mucus from at least one coral. Composition according to claim 1 comprising at least one excipient or vehicle suitable for topical application. Composition according to claim 1 comprising at least one excipient or vehicle suitable for subcutaneous application. Composition according to claim 1 comprising at least one excipient or vehicle suitable for oral administration.

5. Composition according to any one of the preceding claims in which the at least one coral is chosen from soft mucus-producing corals or hard mucus-producing corals.

6. Composition according to any one of the preceding claims in which the mucus is in the viscous state or in the dry state.

7. Cosmetic and non-therapeutic use of mucus from at least one coral.

8. Use according to the preceding claim in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray, a toothpaste.

9. Use according to either of the two preceding claims in a form suitable for topical application to the skin, mucous membranes or appendages.

10. Food supplement comprising the composition according to any one of claims 1, 4 or 5 or 6 in combination with claim 4.

11. Food supplement according to the preceding claim configured to be in the form of a dose, a capsule, a lozenge, a tablet, a pill, a sachet of powder, an ampoule of liquid, a bottle equipped with a dropper.

12. Food supplement according to any one of the two preceding claims in a form suitable for oral application of the food supplement.

13. Composition according to any one of claims 1 to 6 intended for therapeutic application for: - an anti-inflammatory effect, - an antiviral effect, - an antioxidant effect, - acne treatment, - treatment of eczema, - skin photoprotection.