Substituted 5-membered rings and their use as pesticides

Abstract

Disclosed herein are substituted 5-membered ring molecules substituted with fluorinated benzyl groups and amino acid groups of formula (I), and derivatives thereof. The substituted 5-membered ring molecules have herbicidal activity and can be used to control undesirable vegetation. Compositions, methods of preparing, and methods of using the substituted 5-membered ring molecules to control undesirable vegetation are also disclosed.

Description

[0001] SUBSTITUTED 5-MEMBERED RINGS AND THEIR USE AS PESTICIDES CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application Serial No. 63 / 379265, filed on October 12, 2022 and entitled SUBSTITUTED 5-MEMBERED RINGS AND THEIR USE AS PESTICIDES, the entire disclosure of which is hereby expressly incorporated by reference. FIELD The present disclosure is directed to substituted 5-membered ring molecules having herbicidal activity. Methods of synthesizing such substituted 5-membered ring molecules and processes for using these molecules are also disclosed. These molecules may be used, for examples, as herbicides to control undesirable vegetation. BACKGROUND Many recurring problems in agriculture involve controlling the growth of undesirable vegetation. If it is not controlled, the undesirable vegetation can, for instance, negatively affect the growth of desirable vegetation, such as crops, lawns, pastures, gardens, and recreational areas. To help control undesirable vegetation, researchers have produced a variety of chemicals and chemical compositions effective in controlling such unwanted growth. However, there exists an ongoing need for new herbicides and methods to control the growth of undesirable vegetation in various locations. SUMMARY Disclosed herein are molecules, such as substituted 5-membered rings, that may be used as herbicides to control undesirable vegetation in various locations, such as croplands, lawns, pastures, gardens, and recreational areas. The molecules may include lactams or thiolactams, either of which may be substituted with a fluorinated benzyl group and other groups, such as an amino acid or other derivatives thereof. In some aspects, the substituted 5-membered ring molecules are molecules of Formula (I): Formula (I) wherein: X is selected from the group consisting of O and S; Y is selected from the group consisting of O, NR5, and S; R1is selected from the group consisting of H and F; R2is selected from the group consisting of methyl and cyclopropyl; R3is selected from the group consisting of H, methyl, and methoxy; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring; and R5is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C16)-alkenyl, (C3- C16)-alkynyl, (C1-C10)-alkyl-aryl, (C1-C10)-alkoxy, (C3-C10)-alkenyloxy, (C3-C10)-alkynyloxy, aryl-(C1-C10)-alkoxy, heterocyclyl-alkoxy, hydroxy, (C1-C10)-alkyl-sulfonyl, (C3-C8)- cycloalkyl-sulfonyl, (C3-C8)-cycloalkyl-(C1-C10)-alkyl-sulfonyl, aryl-sulfonyl, heteroaryl- sulfonyl, R72R73N-sulfonyl, (C1-C10)-alkoxy-NR74-sulfonyl, and aryl-oxy-sulfonyl. In some aspects, the lactam-based molecules are molecules of Formula (II): Formula (II) wherein: R1is selected from the group consisting of H and F; R2is selected from the group consisting of methyl and cyclopropyl; R3is selected from the group consisting of H, methyl, and methoxy; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (III) Formula (III) wherein: R1is selected from the group consisting of H and F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the thiolactam-based molecules are molecules of Formula (IV): Formula (IV) wherein: X is selected from the group consisting of O and S; R1is selected from the group consisting of H and F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, X is selected from the group consisting of O and S, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (V): Formula (V) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71; R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (VI): Formula (VI) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (VII): Formula (VII) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (VIII): Formula (VIII) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (IX): Formula (IX) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (X): Formula (X) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring. In some aspects, the Substituted 5-Membered Ring Molecules include the molecules listed below in Table 1 as Compound A to Compound O. Table 1A: Exemplary Substituted 5-Membered Ring Molecules

[0002] ! ! Various substituted 5-membered rings, such as lactam-based or thiolactam-based molecules, of included in the present disclosure have been found to exhibit herbicidal activity against various key species of undesirable vegetation. The description below sets forth details of one or more aspects of the present disclosure. Other features, objects, and advantages will be apparent from the description and from the claims. BRIEF DESCRIPTION OF THE DRAWINGS The above mentioned and other features and objects of this disclosure, and the manner of attaining them, will become more apparent and the disclosure itself will be better understood by reference to the following description of exemplary embodiments of the disclosure taken in conjunction with the accompanying drawings, wherein: FIGs.1A and 1B illustrate Table 5A and 5B that contains exemplary post-emergent data; FIG.1C illustrates Table 5C that contains exemplary pre-emergent data; FIG.2 illustrates Tables 6A and 6B that contains exemplary isomer data; FIG.3 illustrates Table 7 that contains exemplary broad leaf crop data; FIGs. 4A-4D illustrate Tables 8A-8D respectively that contain various mixtures with ALS herbicides according to various aspects; FIGs. 5A-4D illustrate Tables 9A-9D respectively that contain various mixtures with auxin herbicides according to various aspects; FIGs. 6A and 6B illustrate Tables 10A and 10B respectively that contain various mixtures with HPPD herbicides according to various aspects; FIGs. 7A and 7B illustrate Tables 11A and 11B respectively that contain various mixtures with PPO herbicides according to various aspects; FIGs.8A-8D illustrate Tables 12A-12D respectively that contain various mixtures with ACCase herbicides according to various aspects; FIG. 9 illustrates Table 13 that contains various mixtures with MAI herbicides according to various aspects; FIG. 10 illustrates Table 14 that contains various mixtures with PSI herbicides according to various aspects; FIG. 11 illustrates Table 15 that contain various mixtures with PDS herbicides according to various aspects; FIG.12 illustrates Table 16 that contains various mixtures with VLCFA herbicides according to various aspects; FIG.13 illustrates Table 17 that contains various mixtures with DOXP herbicides according to various aspects; FIGs.14A and 14B illustrate Tables 18A and 18B respectively that contain various mixtures with PSII herbicides according to various aspects; FIG.15 illustrates Tables 19 that contains various mixtures with EPSPS herbicides according to various aspects; FIG. 16 illustrates Table 20 that contains various mixtures with GS herbicides according to various aspects; FIG. 17 illustrates Table 21 that contains comparative growth rated of various mixtures; and FIGs. 18A and 18B illustrates Table 22A and Table 22B that contain additional herbicidal mixture data. Although the FIGs. contain exemplary data for various aspects of the present disclosure—in various forms—such exemplifications are not to be construed as limiting the scope of the disclosure in any manner. DETAILED DESCRIPTION The present disclosure includes molecules that may be used as herbicides to control undesirable vegetation in various locations, such as croplands, lawns, pastures, gardens, and recreational areas. These substituted 5-membered ring molecules, such as lactams or thio- lactams, may be substituted with fluorinated benzyl groups and other groups, such as amino acid groups or derivatives thereof. The present disclosure also includes methods for using the molecules for controlling undesirable vegetation. In some aspects, the undesirable vegetation is in row crops. In some aspects, the undesirable vegetation is in maize, soy, canola, cotton, pulses, sunflower, sugar beet, wheat, barley, rice, sorghum, millet, or oats. In some aspects, the molecules are graminicides used to control undesirable vegetation including grass-type species. 1. Definitions Terms used herein will have their customary meaning in the art unless specified otherwise. The singular forms "a" and "the" include plural references unless stated otherwise. To the extent that the term "or" is employed (e.g., A or B) it is intended to mean "A or B or both." If this disclosure intends to indicate "only A or B but not both" then the term "only A or B but not both" will be employed. Thus, use of the term "or" herein is the inclusive and not the exclusive use. As used herein, the terms “herbicide” and “herbicidal active ingredient” refer to an active ingredient that kills, controls, or otherwise adversely modifies the growth of vegetation, particularly undesirable vegetation such as weed species, when applied in an appropriate amount. As used herein, the term “herbicidal effect” is an adversely modifying effect of an active ingredient on vegetation, including, for example, a deviation from natural growth or development, killing, regulation, desiccation, growth inhibition, growth reduction, and retardation. The term "herbicidal activity" refers generally to herbicidal effects of an active ingredient. As used herein, the term “herbicide resistance” refers to an inherited ability of an individual plant to survive an herbicide application that would kill a normal population of the same species of plant. Herbicide resistance in a plant species often arises due to the application of an herbicide on plants of that species in a specific location. As used herein, the term “herbicide tolerance” refers to the inherent ability of a species of plants to survive and reproduce after herbicide treatment at a normal use rate. Herbicide tolerance is therefore a natural tolerance within the normal population of the plant species, rather than resistance selected for in that species by the application of an herbicide. As used herein, a “composition” is a mixture comprising at least one herbicide, and also comprising other ingredients used to enhance the properties or effectiveness of the mixture in some way. The other ingredients may include, but are not limited to, diluents, surfactants, adjuvants, anti-foam agents, emulsifiers, colorants, dispersants, antifreeze agents, and other such ingredients. As used herein, "applying" an herbicide or herbicidal composition refers to delivering it directly to the targeted vegetation or to the locus thereof or to the area where control of undesirable vegetation is desired. Methods of application include, but are not limited to, pre-emergently contacting soil or water, post-emergently contacting the undesirable vegetation, or contacting the area adjacent to the undesirable vegetation. As used herein, the term “vegetation” can include, for instance, dormant seeds, germinating seeds, emerging seedlings, plants propagating from vegetative propagules, immature vegetation, and established vegetation. As used herein, the term "crop" refers to desired vegetation, for instance, plants that are grown to provide food, shelter, pasture, erosion control, etc. Example crops include cereals, legumes, vegetables, orchard and timber trees, grapevines, etc. Preferably, herbicides or herbicidal compositions have zero or minimal herbicidal effect on crops. As used herein, the term "undesirable vegetation" refers to vegetation that is not wanted in a given area, for instance, weed species. Herbicides or herbicidal compositions are used to control undesirable vegetation. Preferably, herbicides or herbicidal compositions have a large or complete herbicidal effect on undesirable vegetation. As used herein, unless otherwise specified, “acyl” refers to formyl, C1-C3 alkylcarbonyl, and C1-C3 haloalkylcarbonyl. C1-C6 acyl refers to formyl, C1-C5 alkylcarbonyl, and C1-C5 haloalkylcarbonyl (the group contains a total of 1 to 6 carbon atoms). As used herein, “alkyl” refers to saturated, straight-chained or branched saturated hydrocarbon moieties. Unless otherwise specified, C1-C16 alkyl groups are intended. Examples include methyl, ethyl, propyl, 1-methyl-ethyl, butyl, 1-methyl-propyl, 2-methyl- propyl, 1,1-dimethyl-ethyl, pentyl, 1-methyl-butyl, 2-methyl-butyl, 3-methyl-butyl, 2,2- dimethyl-propyl, 1-ethyl-propyl, hexyl, 1,1-dimethyl-propyl, 1,2-dimethyl-propyl, 1-methyl- pentyl, 2-methyl-pentyl, 3-methyl-pentyl, 4-methyl-pentyl, 1,1-dimethyl-butyl, 1,2-dimethyl- butyl, 1,3-dimethyl-butyl, 2,2-dimethyl-butyl, 2,3-dimethyl-butyl, 3,3-dimethyl-butyl, 1-ethyl- butyl, 2-ethyl-butyl, 1,1,2-trimethyl-propyl, 1,2,2-trimethyl-propyl, 1-ethyl-1-methyl-propyl, and 1-ethyl-2-methyl-propyl. As used herein, “haloalkyl” refers to straight-chained or branched alkyl groups, where in these groups the hydrogen atoms may be substituted partially or entirely with halogen atoms. Unless otherwise specified, C1-C16 groups are intended. Examples include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1- chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2- trichloroethyl, pentafluoroethyl, and 1,1,1-trifluoroprop-2-yl. As used herein, “alkenyl” refers to unsaturated, straight-chained, or branched hydrocarbon moieties containing a double bond. Unless otherwise specified, C3-C16 alkenyl are intended. Alkenyl groups may contain more than one unsaturated bond. Examples include ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl- 1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2- pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1- butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2- methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3- hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1- pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2- pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3- pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4- pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl- 1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3- dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3,3-dimethyl-2- butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2- butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl- 2-methyl-1-propenyl, and 1-ethyl-2-methyl-2-propenyl. Vinyl refers to a group having the strutcture –CH=CH2; 1-propenyl refers to a group with the structure–CH=CH-CH3; and 2- propenyl refers to a group with the structure –CH2-CH=CH2. As used herein, “alkynyl” represents straight-chained or branched hydrocarbon moieties containing a triple bond. Unless otherwise specified, C3-C16 alkynyl groups are intended. Alkynyl groups may contain more than one unsaturated bond. Examples include C2- C6-alkynyl, such as ethynyl, 1-propynyl, 2-propynyl (or propargyl), 1-butynyl, 2-butynyl, 3- butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 3-methyl-1- butynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1,1-dimethyl-2- propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 3- methyl-1-pentynyl, 4-methyl-1-pentynyl, 1-methyl-2-pentynyl, 4-methyl-2-pentynyl, 1- methyl-3-pentynyl, 2-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-4-pentynyl, 3- methyl-4-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2- ethyl-3-butynyl, and 1-ethyl-1-methyl-2-propynyl. As used herein, “alkoxy” refers to a group of the formula R-O-, where R is alkyl as defined above. Unless otherwise specified, alkoxy groups wherein R is a C1-C10alkyl group are intended. Examples include methoxy, ethoxy, propoxy, 1-methyl-ethoxy, butoxy, 1- methyl-propoxy, 2-methyl-propoxy, 1,1-dimethyl-ethoxy, pentoxy, 1-methyl-butyloxy, 2- methyl-butoxy, 3-methyl-butoxy, 2,2-dimethyl-propoxy, 1-ethyl-propoxy, hexoxy, 1,1- dimethyl-propoxy, 1,2-dimethyl-propoxy, 1-methyl-pentoxy, 2-methyl-pentoxy, 3-methyl- pentoxy, 4-methyl-pentoxy, 1,1-dimethyl-butoxy, 1,2-dimethyl-butoxy, 1,3-dimethyl-butoxy, 2,2-dimethyl-butoxy, 2,3-dimethyl-butoxy, 3,3-dimethyl-butoxy, 1-ethyl-butoxy, 2-ethyl- butoxy, 1,1,2-trimethyl-propoxy, 1,2,2-trimethyl-propoxy, 1-ethyl-1-methyl-propoxy, and 1- ethyl-2-methyl-propoxy. As used herein, “haloalkoxy” refers to a group of the formula R-O-, where R is haloalkyl as defined above. Unless otherwise specified, haloalkoxy groups wherein R is a C1- C10alkyl group are intended. Examples include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1- bromoethoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2- chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2- trichloroethoxy, pentafluoroethoxy, and 1,1,1-trifluoroprop-2-oxy. As used herein, “alkylthio” refers to a group of the formula R-S- where R is alkyl as defined above. Unless otherwise specified, alkylthio groups wherein R is a C1-C10alkyl group are intended. Examples include methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methyl-propylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1- methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1- ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1- methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1- dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3- dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2- trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio, and 1-ethyl-2- methylpropylthio. As used herein, “haloalkylthio” refers to an alkylthio group as defined above wherein the carbon atoms are substituted partially or entirely with halogen atoms. Unless otherwise specified, haloalkylthio groups wherein R is a C1-C8alkyl group are intended. Examples include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1- chloroethylthio, 1-bromoethylthio, 1-fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2-chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2- dichloro-2-fluoroethylthio, 2,2,2-trichloroethylthio, pentafluoroethylthio, and 1,1,1- trifluoroprop-2-ylthio. As used herein, “aryl”, as well as derivative terms such as aryloxy, refers to a phenyl, indanyl or naphthyl group with phenyl being preferred. The term heteroaryl, as well as derivative terms such as heteroaryloxy, refers to a 5- or 6-membered aromatic ring containing one or more heteroatoms, viz., N, O or S; these aromatic and heteroaromatic rings may be fused to other aromatic and / or heteroaromatic systems. The aryl or heteroaryl substituents may be unsubstituted or substituted with one or more substituents selected from halogen, hydroxy, nitro, cyano, formyl, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6haloalkyl, C1-C6haloalkoxy, C1-C6acyl, C1-C6alkylthio, C1-C6alkylsulfinyl, C1-C6alkylsulfonyl, C1-C6alkoxycarbonyl, C1-C6carbamoyl, hydroxycarbonyl, C1-C6alkylcarbonyl, aminocarbonyl, C1- C6alkylaminocarbonyl, C1-C6dialkylaminocarbonyl, provided that the substituents are sterically compatible and the rules of chemical bonding and strain energy are satisfied. As used herein “alkylcarbonyl” refers to an alkyl group bonded to a carbonyl group. C1-C3 alkylcarbonyl and C1-C3 haloalkylcarbonyl refer to groups wherein a C1-C3 alkyl group is bonded to a carbonyl group (the group contains a total of 2 to 4 carbon atoms). O As used herein, “alkoxycarbonyl” refers to a group of the formula wherein R is alkyl. As used herein, “arylalkyl” refers to an alkyl group substituted with an aryl group. C7-C10arylalkyl refers to a group wherein the total number of carbon atoms in the group is 7 to 10. As used herein alkylamino refers to an amino group substituted with one or two alkyl groups, which may be the same or different. As used herein haloalkylamino refers to an alkylamino group wherein the alkyl carbon atoms are substituted partially or entirely with halogen atoms. As used herein, C1-C6 alkylaminocarbonyl refers to a group of the formula RNHC(O)- wherein R is C1-C6 alkyl, and C1-C6 dialkylaminocarbonyl refers to a group of the formula R2NC(O)- wherein each R is independently C1-C6 alkyl. As used herein alkylcarbamyl refers to a carbamyl group substituted on the nitrogen with an alkyl group. As used herein “alkyl-sulfonyl” refers to a group of the formula , where R is alkyl. As used herein carbamyl (also referred to as carbamoyl and aminocarbonyl) refers to a group of the formula . As used herein dialkylphosponyl refers to a group of the formula where R is independently alkyl in each occurrence. As used herein, C1-C6 trialkylsilyl refers to a group of the formula –SiR3 wherein each R is independently a C1-C6 alkyl group (the group contains a total of 3 to 18 carbon atoms). As used herein Me refers to a methyl group; OMe refers to a methoxy group; i-Pr refers to an isopropyl group. As used herein, the term halogen including derivative terms such as halo refers to fluorine, chlorine, bromine and iodine. As used herein, agriculturally acceptable salts and esters refer to salts and esters that exhibit herbicidal activity or that are or can be converted in plants, water, or soil to the referenced herbicide. Exemplary agriculturally acceptable esters are those that are or can by hydrolyzed, oxidized, metabolized, or otherwise converted, e.g., in plants, water, or soil, to the corresponding carboxylic acid which, depending on the pH, may be in the dissociated or undissociated form. As used herein, "active ingredient" or "ai" refers to a chemical compound or composition that has an effect on vegetation, for example, a herbicidal effect or a safening effect on the vegetation. As used herein, "acid equivalent" or "ae" refers to the amount of the acid form of an active ingredient that is calculated from the amount of a salt or ester form of that active ingredient. For example, if the acid form of an active ingredient "Z" has a molecular weight of 100 Dalton, and the salt form of Z has a molecular weight of 130 Dalton, an application of 130 grams of active ingredient per hectare (g ai / ha) of the Z salt would be equal to applying 100 grams of acid equivalent per hectare (g ae / ha) of the acid form of Z: 130 g ai / ha Z salt * (100 Da Z acid / 130 Da Z salt) = 100 g ae / ha Z acid. 2. Substituted 5-Membered Ring Molecules Disclosed herein are substituted 5-membered ring molecules, such as substituted lactam-molecules or thiolactam-molecules, that may be used as herbicides to control undesirable vegetation in various locations, such as croplands, lawns, pastures, gardens, and recreational areas. The molecules include molecules that are substituted with fluorinated benzyl groups and amino acid groups, and derivatives thereof. In some aspects, the substituted 5-membered ring molecules are molecules of Formula (I): Formula (I) wherein: X is selected from the group consisting of O and S; Y is selected from the group consisting of O, NR5, or S; R1is selected from the group consisting of H and F; R2is selected from the group consisting of methyl and cyclopropyl; R3is selected from the group consisting of H, methyl, and methoxy; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring; and R5is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C16)-alkenyl, (C3- C16)-alkynyl, (C1-C10)-alkyl-aryl, (C1-C10)-alkoxy, (C3-C10)-alkenyloxy, (C3-C10)-alkynyloxy, aryl-(C1-C10)-alkoxy, heterocyclyl-alkoxy, hydroxy, (C1-C10)-alkyl-sulfonyl, (C3-C8)- cycloalkyl-sulfonyl, (C3-C8)-cycloalkyl-(C1-C10)-alkyl-sulfonyl, aryl-sulfonyl, heteroaryl- sulfonyl, R72R73N-sulfonyl, (C1-C10)-alkoxy-NR74-sulfonyl, and aryl-oxy-sulfonyl. In some aspects, the lactam-based molecules are molecules of Formula (II): Formula (II) wherein: R1is selected from the group consisting of H and F; R2is selected from the group consisting of methyl and cyclopropyl; R3is selected from the group consisting of H, methyl, and methoxy; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (III) Formula (III) wherein: R1is selected from the group consisting of H and F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the thiolactam-based molecules are molecules of Formula (IV): wherein: X is selected from O or S; R1is selected from H or F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, X is selected from the group consisting of O and S, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the substituted 5-membered ring molecules are molecules of Formula (V): Formula (V) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the substituted 5-membered ring molecules are molecules of Formula (VI): Formula (VI) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (VII): Formula (VII) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (VIII): Formula (VIII) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (IX):

[0003] Formula (IX) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the lactam-based molecules are molecules of Formula (X):

[0004] Formula (X) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, or NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring. In some aspects, the substituted 5-membered ring molecules include the molecules given below as Compound A to Compound O. Table 1B: Exemplary Substituted 5-Membered Ring Molecules E 小 The substituted 5-membered ring molecules of the present disclosure exist in specific chiral forms, as shown in the molecular structures shown above. However, the substituted 5-membered ring molecules may also exist in different geometric or optical isomeric forms at other locations within each molecule. It will be appreciated by those skilled in the art, with the benefit of this disclosure, that one stereoisomer may be more active than the other stereoisomers. Individual stereoisomers may be obtained by known selective synthetic procedures, by conventional synthetic procedures using resolved starting materials, or by conventional resolution procedures, using the procedures and compositions disclosed herein. This disclosure covers all such chiral forms, isomers, and mixtures thereof, in all proportions. For example, while FIGs.1A – 1C contain exemplary post-emergent data (Tables 5A and 5B) and pre-emergent data (Table 5C) respectively, FIG.2 contains Tables 6A and 6B contains comparative pre-emergent isomer, for example, from some of the isomers shown below in Table 2B. Table 2: Exemplary Isomers 3. Preparation of Substituted 5-membered Ring Molecules Substituted 5-membered ring molecules of the present disclosure were prepared in accordance with the procedures given below. Compound A: Methyl (2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetyl)-L-valinate Compound A Compound A was prepared as follows: In a 250 mL round-bottomed flask charged with a magnetic stir bar were added (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid (1.1 grams (g), 4.0 millimoles (mmol)) and methyl L-valinate hydrochloride (0.67 g, 4.0 mmol) in dichloromethane (CH2Cl2, 40 milliliters (mL)).3-(((Ethylimino)methylene)amino)- N,N-dimethylpropan-1-amine) hydrochloride (0.92 g, 4.8 mmol), triethylamine (0.67 mL, 4.8 mmol), and N,N-dimethylpyridin-4-amine (0.59 g, 4.8 mmol) were added sequentially. The reaction mixture was stirred at 20 °C for 18 hours (h). The reaction product, Compound A, was concentrated onto Celite®and purified by silica column chromatography. The reaction product was isolated as a slightly yellow sticky oil (89% yield, 97% purity). The following data were generated to confirm the identity of Compound A: ESIMS m / z 383.2 ([M+H]+);1H NMR (500 MHz, CDCl3) δ 7.13 – 7.00 (m, 3H), 5.96 (d, J = 8.7 Hz, 1H), 4.86 (dd, J = 15.6, 1.7 Hz, 1H), 4.54 (dd, J = 8.6, 4.8 Hz, 1H), 4.25 (d, J = 15.6 Hz, 1H), 3.96 (tt, J = 8.7, 4.5 Hz, 1H), 3.75 (s, 3H), 2.69 (dd, J = 14.4, 4.2 Hz, 1H), 2.51 (ddd, J = 16.8, 9.7, 7.0 Hz, 1H), 2.40 (ddd, J = 17.1, 9.8, 5.9 Hz, 1H), 2.31 – 2.19 (m, 2H), 2.18 – 2.11 (m, 1H), 1.82 (dddd, J = 13.2, 9.6, 5.9, 4.6 Hz, 1H), 0.92 (d, J = 6.8 Hz, 3H), 0.89 (d, J = 6.9 Hz, 3H);19F NMR (471 MHz, CDCl3) δ -137.81 (d, J = 20.9 Hz), -144.12 (d, J = 20.8 Hz). Compound B: Methyl (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5- oxopyrrolidin-2-yl)acetamido)propanoate Compound B Compound B was prepared as follows: In a 45 mL reaction vial charged with a magnetic stir bar were added (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid (0.40 g, 1.5 mmol) and methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride (0.27 g, 1.5 mmol) in CH2Cl2(15 mL). 3-(((Ethylimino)methylene)amino)-N,N-dimethylpropan-1- amine hydrochloride (0.35 g, 1.8 mmol), triethylamine (250 microliters (µL), 1.80 mmol) and N,N-dimethylpyridin-4-amine (0.22 g, 1.8 mmol) were added sequentially. The reaction mixture was stirred at 20 °C for 72 h. The reaction product, Compound B, was concentrated and purified by silica column chromatography. The reaction product was isolated as a clear oil (85% yield, 95% purity). The following data were generated to confirm the identity of Compound B: ESIMS m / z 395.2 ([M+H]+);1H NMR (400 MHz, CDCl3) δ 7.12 – 6.98 (m, 3H), 6.14 (d, J = 7.7 Hz, 1H), 4.86 (dd, J = 15.6, 1.7 Hz, 1H), 4.64 (dt, J = 7.8, 5.8 Hz, 1H), 4.25 (d, J = 15.6 Hz, 1H), 3.96 (tt, J = 8.6, 4.4 Hz, 1H), 3.75 (s, 3H), 2.67 (dd, J = 14.5, 4.4 Hz, 1H), 2.56 – 2.31 (m, 2H), 2.32 – 2.14 (m, 2H), 1.83 (dddd, J = 13.0, 10.0, 5.8, 4.5 Hz, 1H), 1.76 – 1.63 (m, 2H), 0.71 – 0.56 (m, 1H), 0.54 – 0.40 (m, 2H), 0.12 – 0.03 (m, 2H);19F NMR (376 MHz, CDCl3) δ -137.83 (d, J = 21.2 Hz), -144.09 (d, J = 20.8 Hz). Compound C: Methyl (2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetyl)- L-valinate Compound C Compound C was prepared as follows: In a 20 mL reaction vial charged with a magnetic stir bar was added (S)-2-(1-(2,3,5-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid (290 mg, 1.0 mmol), methyl L-valinate hydrochloride (170 mg, 1.0 mmol), 3- (((ethylimino)methylene)amino)-N,N-dimethylpropan-1-amine hydrochloride (210 mg, 1.1 mmol), and N,N-dimethylpyridin-4-amine (130 mg, 1.1 mmol), followed by CH2Cl2 (5 mL) and then triethylamine (280 µl, 2.0 mmol). The reaction was stirred at 22 °C for 16 hr. The reaction product was isolated as a viscous colorless oil (71% yield, 95% purity). The following data were generated to confirm the identity of Compound C: ESIMS m / z 401.2 ([M+H]+);1H NMR (500 MHz, CDCl3) δ 6.90 – 6.81 (m, 1H), 6.77 (ddt, J = 7.7, 4.9, 2.5 Hz, 1H), 6.03 (d, J = 8.9 Hz, 1H), 4.79 (dt, J = 15.9, 1.1 Hz, 1H), 4.55 (dd, J = 8.7, 4.8 Hz, 1H), 4.27 (d, J = 15.8 Hz, 1H), 4.00 (tt, J = 7.9, 4.6 Hz, 1H), 3.75 (d, J = 1.2 Hz, 3H), 2.66 (dd, J = 14.6, 4.6 Hz, 1H), 2.57 – 2.48 (m, 1H), 2.47 – 2.38 (m, 1H), 2.36 – 2.23 (m, 2H), 2.17 – 2.12 (m, 1H), 1.83 (dddd, J = 13.0, 9.6, 6.0, 4.8 Hz, 1H), 0.91 (dd, J = 15.1, 6.9 Hz, 6H);19F NMR (471 MHz, CDCl3) δ -114.27 – -114.34 (m), -132.93 (dd, J = 21.2, 3.1 Hz), -148.73 (dd, J = 21.0, 15.3 Hz). Compound D: Methyl (S)-3-cyclopropyl-2-(2-((S)-5-oxo-1-(2,3,5- trifluorobenzyl)pyrrolidin-2-yl)acetamido)propanoate Compound D Compound D was prepared as follows: In a 45 mL reaction vial charged with a magnetic stir bar were added (S)-2-(5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetic acid (0.57 g, 2.0 mmol) and methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride (0.36 g, 2.0 mmol) in CH2Cl2 (20 mL). 3-(((Ethylimino)methylene)amino)-N,N-dimethylpropan-1- amine hydrochloride (0.46 g, 2.4 mmol), triethylamine (340 µL, 2.4 mmol) and N,N- dimethylpyridin-4-amine (290 mg, 2.4 mmol) were added. The reaction mixture was stirred at 20 °C for 18 h. The reaction product, Compound D, was concentrated and purified by silica column chromatography. The reaction product was isolated as a yellow oil (95% yield, 97% purity). The following data were generated to confirm the identity of Compound D: ESIMS m / z 413.3 ([M+H]+]);1H NMR (500 MHz, CDCl3) δ 6.84 (dddd, J = 9.6, 7.9, 6.1, 3.1 Hz, 1H), 6.77 (ddt, J = 7.7, 4.9, 2.5 Hz, 1H), 6.18 (d, J = 7.7 Hz, 1H), 4.78 (dt, J = 15.9, 1.1 Hz, 1H), 4.64 (dt, J = 7.7, 5.8 Hz, 1H), 4.27 (d, J = 15.8 Hz, 1H), 4.00 (tt, J = 8.1, 4.7 Hz, 1H), 3.75 (s, 3H), 2.63 (dd, J = 14.6, 4.7 Hz, 1H), 2.56 – 2.46 (m, 1H), 2.41 (ddd, J = 17.1, 9.7, 5.9 Hz, 1H), 2.36 – 2.21 (m, 2H), 1.83 (dddd, J = 13.1, 9.6, 5.8, 4.6 Hz, 1H), 1.76 – 1.63 (m, 2H), 0.69 – 0.58 (m, 1H), 0.53 – 0.41 (m, 2H), 0.10 – 0.01 (m, 2H);19F NMR (471 MHz, CDCl3) δ -114.22 – -114.39 (m), -132.92 – -133.02 (m), -148.63 – -148.75 (m). Compound E: (2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetyl)-L-valine Compound E was prepared as follows: In a 25 mL reaction vial charged with a magnetic stir bar was added methyl (2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetyl)-L-valinate (0.15 g, 0.38 mmol) in a THF (1.1 mL) / Water (0.37 mL) solvent mixture. Lithium hydroxide (0.046 g, 1.9 mmol) was added, and the reaction mixture was stirred at 20 °C for 18 h. The reaction mixture was acidified with 1 molar (M) hydrochloric acid (HCl, 1.9 mL) and diluted with CH2Cl2(5 mL). The resulting mixture was concentrated and diluted with water and ethyl acetate. To the aqueous layer was added brine (10 mL), and the resulting mixture was extracted with additional ethyl acetate (50 mL x 3). The combined organic layers were dried over sodium sulfate and concentrated to give Compound E. The reaction product was isolated as a white solid (97% yield, 98% purity). The following data were generated to confirm the identity of Compound E: ESIMS m / z 369.2 ([M+H]+);1H NMR (500 MHz, DMSO-d6) δ 12.62 (br s, 1H), 8.17 (d, J = 8.6 Hz, 1H), 7.34 (dtd, J = 9.9, 8.0, 1.7 Hz, 1H), 7.18 (tdd, J = 8.2, 5.0, 1.5 Hz, 1H), 7.11 – 7.04 (m, 1H), 4.74 (d, J = 15.8 Hz, 1H), 4.24 (d, J = 15.9 Hz, 1H), 4.17 (dd, J = 8.6, 5.6 Hz, 1H), 3.77 (tt, J = 8.4, 4.3 Hz, 1H), 2.57 (dd, J = 13.7, 4.5 Hz, 1H), 2.42 – 2.32 (m, 2H), 2.24 (ddd, J = 16.7, 9.7, 5.0 Hz, 1H), 2.16 – 1.99 (m, 2H), 1.77 (ddt, J = 13.4, 9.3, 4.7 Hz, 1H), 0.89 – 0.83 (m, 6H);19F NMR (471 MHz, DMSO-d6) δ - 139.32 (d, J = 22.1 Hz), -144.08 (d, J = 22.1 Hz). Compound F: (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetamido)propanoic acid Compound F Compound F was prepared as followed: In a 25 mL reaction vial charged with a magnetic stir bar were added lithium hydroxide (0.097 g, 4.1 mmol) and methyl (S)-3- cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetamido)-propanoate (0.32 g, 0.81 mmol) in a THF (2.4 mL) / Water (0.8 mL) solvent mixture. The reaction mixture was stirred at 20 °C for 18 h. The reaction mixture was acidified with 1 normal (N) HCl (4.5 mL). The reaction mixture was diluted with CH2Cl2(5 mL) and saturated NaCl (20 mL) and extracted with ethyl acetate (50 mL x 3). The combined organic layers were dried with sodium sulfate and concentrated. The reaction product, Compound F, was isolated as a white solid (96% yield, 95% purity). The following data were generated to confirm the identity of Compound F: ESIMS m / z 381.1 ([M+H]+);1H NMR (400 MHz, DMSO-d6) δ 12.58 (br s, 1H), 8.33 (d, J = 7.9 Hz, 1H), 7.34 (dtd, J = 9.9, 8.0, 1.6 Hz, 1H), 7.18 (td, J = 8.1, 5.3 Hz, 1H), 7.07 (t, J = 7.0 Hz, 1H), 4.74 (d, J = 15.9 Hz, 1H), 4.29 – 4.20 (m, 2H), 3.78 (tt, J = 8.3, 4.2 Hz, 1H), 2.56 (dd, J = 13.8, 4.6 Hz, 1H), 2.43 – 2.17 (m, 3H), 2.10 (dt, J = 12.9, 8.5 Hz, 1H), 1.77 (ddt, J = 13.5, 9.3, 4.5 Hz, 1H), 1.61 – 1.45 (m, 2H), 0.73 (qq, J = 7.5, 4.9, 3.8 Hz, 1H), 0.38 (qq, J = 8.8, 4.4 Hz, 2H), 0.13 (dq, J = 7.5, 4.1, 3.7 Hz, 1H), 0.02 (dq, J = 7.7, 3.4, 2.9 Hz, 1H);19F NMR (376 MHz, DMSO-d6) δ -139.32 (d, J = 22.1 Hz), -144.08 (d, J = 22.0 Hz). Compound G: (2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetyl)-L-valine Compound G Compound G was prepared as follows: In a 20 mL vial charged with a magnetic stir bar were added methyl (2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetyl)-L- valinate (0.50 g, 1.3 mmol) and sodium hydroxide (0.10 g, 2.5 mmol) in methanol (5.0 mL) under air. To this was added water (1.3 mL), and the reaction mixture was stirred at 70 °C for 16 h. The reaction mixture was diluted with water (5 mL) and acidified with concentrated HCl to pH 2. The reaction product, Compound G, began to precipitate as a white solid after a few moments. The acidified mixture was stirred for 5 minutes, and the precipitated reaction product was collected by filtration. The solid thus obtained was washed with water and dried under air. The reaction product was isolated as a white powder (88% yield, 95% purity). The following data were generated to verify the identity of Compound G: ESIMS m / z 387.1 ([M+H]+);1H NMR (500 MHz, DMSO-d6) δ 12.68 (s, 1H), 8.16 (d, J = 8.6 Hz, 1H), 7.45 (dddd, J = 11.3, 8.9, 6.1, 3.1 Hz, 1H), 6.95 (dd, J = 5.7, 3.2 Hz, 1H), 4.70 (d, J = 16.1 Hz, 1H), 4.26 (d, J = 16.1 Hz, 1H), 4.17 (dd, J = 8.6, 5.6 Hz, 1H), 3.82 (ddd, J = 12.6, 8.3, 4.3 Hz, 1H), 2.58 (dd, J = 13.9, 4.7 Hz, 1H), 2.36 (ddd, J = 17.0, 8.9, 6.1 Hz, 2H), 2.26 (ddd, J = 16.6, 9.7, 5.2 Hz, 1H), 2.12 (ddt, J = 12.6, 9.8, 7.7 Hz, 1H), 2.04 (dq, J = 13.3, 6.7 Hz, 1H), 1.78 (dp, J = 13.8, 4.9 Hz, 1H), 0.86 (dd, J = 6.9, 4.0 Hz, 6H);19F NMR (471 MHz, DMSO-d6) δ -114.86 (dd, J = 15.4, 3.3 Hz), -134.42 (dd, J = 21.8, 3.3 Hz), -148.01 (dd, J = 22.1, 15.2 Hz).

[0005] Compound H: (S)-3-cyclopropyl-2-(2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)- pyrrolidin-2-yl)acetamido)propanoic acid Compound H Compound H was prepared as follows: In a 25 mL reaction vial charged with a magnetic stir bar were added methyl (S)-3-cyclopropyl-2-(2-((S)-5-oxo-1-(2,3,5- trifluorobenzyl)pyrrolidin-2-yl)acetamido)propanoate (580 mg, 1.4 mmol) and lithium hydroxide (0.17 g, 7.0 mmol) in a THF (4.2 mL) / Water (1.4 mL) solvent mixture. The reaction mixture was stirred at 20 °C for 18 h. The reaction mixture was acidified with 1 M HCl (7.5 mL), diluted with water (10 mL), and extracted with ethyl acetate (50 mL x 3). The combined organic layers were dried with sodium sulfate and concentrated. The reaction product, Compound H, was isolated as a white solid (89% yield, 97% purity). The following data were generated to verify the identity of Compound H: ESIMS m / z 399.3 ([M+H]+);1H NMR (400 MHz, DMSO-d6) δ 12.61 (br s, 1H), 8.32 (d, J = 7.8 Hz, 1H), 7.46 (dddd, J = 11.2, 9.0, 6.2, 3.2 Hz, 1H), 6.95 (dp, J = 8.1, 2.4 Hz, 1H), 4.70 (d, J = 16.1 Hz, 1H), 4.29 – 4.19 (m, 2H), 3.82 (tt, J = 8.3, 4.4 Hz, 1H), 2.55 (dd, J = 13.9, 4.8 Hz, 1H), 2.42 – 2.19 (m, 3H), 2.12 (ddt, J = 12.7, 9.6, 7.7 Hz, 1H), 1.77 (ddt, J = 13.7, 9.5, 4.7 Hz, 1H), 1.62 – 1.43 (m, 2H), 0.73 (dtt, J = 12.2, 7.1, 3.7 Hz, 1H), 0.45 – 0.31 (m, 2H), 0.13 (dtd, J = 8.7, 4.5, 2.9 Hz, 1H), 0.06 – 0.00 (m, 1H);19F NMR (376 MHz, DMSO-d6) δ -114.83 – -114.96 (m), -134.34 – -134.54 (m), -148.01 (dd, J = 22.2, 15.3 Hz). Compound I: Methyl N-(2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetyl)-O- methyl-L-threoninate Compound I Compound I was prepared as follows: In a 45 mL reaction vial charged with a magnetic stir bar were added (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid (0.40 g, 1.5 mmol) and methyl O-methyl-L-threoninate hydrochloride (0.28 g, 1.5 mmol) in CH2Cl2(15.0 mL). 3-(((Ethylimino)methylene)amino)-N,N-dimethylpropan-1-amine hydrochloride (0.35 g, 1.8 mmol), triethylamine (0.25 mL, 1.8 mmol) and N,N- dimethylpyridin-4-amine (0.22 g, 1.8 mmol) were added to the reaction mixture. The reaction mixture was stirred at 20 °C for 18 h. The reaction product, Compound I, was concentrated and purified by silica column chromatography. The reaction product was isolated as a clear oil (85% yield, 97% purity). The following data were generated to verify the identity of Compound I: ESIMS m / z 399.2 ([M+H]+);1H NMR (400 MHz, CDCl3) δ 7.14 – 6.98 (m, 3H), 6.18 (d, J = 9.1 Hz, 1H), 4.88 (d, J = 15.7 Hz, 1H), 4.59 (dd, J = 9.1, 2.3 Hz, 1H), 4.25 (d, J = 15.6 Hz, 1H), 4.01 – 3.88 (m, 2H), 3.75 (s, 3H), 3.28 (s, 3H), 2.73 (dd, J = 14.4, 4.2 Hz, 1H), 2.51 (ddd, J = 16.8, 9.5, 7.0 Hz, 1H), 2.39 (ddd, J = 17.0, 9.7, 5.7 Hz, 1H), 2.32 – 2.19 (m, 2H), 1.90 – 1.78 (m, 1H), 1.15 (d, J = 6.3 Hz, 3H);19F NMR (376 MHz, CDCl3) δ -137.86 (d, J = 20.8 Hz), -144.01 (d, J = 19.3 Hz).

[0006] Compound J: N-(2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetyl)-O- methyl-L-threonine Compound J Compound J was prepared as follows: In a 25 mL reaction vial charged with a magnetic stir bar were added methyl N-(2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetyl)-O-methyl-L-threoninate (0.40 g, 1.0 mmol) and lithium hydroxide (0.12 g, 5.1.0 mL) solvent mixture. The reaction mixture was stirred at 20 °C for 20 h. The reaction mixture was acidified with 1 M HCl (5.5 mL) and diluted with water (10 mL) and ethyl acetate (20 mL). The aqueous layer of the reaction mixture was extracted with ethyl acetate (30 mL x 4). The combined organic layers were dried with sodium sulfate and concentrated. The reaction product was isolated as a white solid (80% yield, 98% purity). The following data were generated to verify the identity of Compound J: ESIMS m / z 385.0 ([M+H]+);1H NMR (400 MHz, DMSO-d6) δ 12.71 (br s, 1H), 8.22 (d, J = 9.0 Hz, 1H), 7.35 (dtd, J = 9.8, 8.0, 1.7 Hz, 1H), 7.18 (tdd, J = 8.2, 5.0, 1.5 Hz, 1H), 7.15 – 7.03 (m, 1H), 4.74 (d, J = 15.9 Hz, 1H), 4.37 (dd, J = 9.0, 3.1 Hz, 1H), 4.25 (d, J = 15.9 Hz, 1H), 3.85 (qd, J = 6.2, 3.0 Hz, 1H), 3.76 (tt, J = 8.3, 4.1 Hz, 1H), 3.22 (s, 3H), 2.62 (dd, J = 13.5, 4.4 Hz, 1H), 2.38 (ddd, J = 17.0, 13.1, 8.7 Hz, 2H), 2.23 (ddd, J = 16.6, 9.6, 4.8 Hz, 1H), 2.14 – 2.00 (m, 1H), 1.79 (ddt, J = 13.4, 9.2, 4.5 Hz, 1H), 1.03 (d, J = 6.3 Hz, 3H);19F NMR (376 MHz, DMSO-d6) δ -139.37 (d, J = 22.1 Hz), -144.07 (d, J = 22.1 Hz). Compound K: Methyl O-methyl-N-(2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin- 2-yl)acetyl)-L-threoninate Compound K Compound K was prepared as follows: In a 45 mL reaction vial charged with a magnetic stir bar were added (S)-2-(5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetic acid (0.29 g, 1.0 mmol) and methyl O-methyl-L-threoninate hydrochloride (0.18 g, 1.0 mmol) in CH2Cl2(10 mL). 3-(((Ethylimino)methylene)amino)-N,N-dimethylpropan-1-amine hydrochloride (0.23 g, 1.2 mmol), triethylamine (170 µL, 1.2 mmol) and N,N-dimethylpyridin- 4-amine (0.15 g, 1.2 mmol) were added sequentially. The reaction mixture was stirred at 20 °C for 18 h. The reaction product, Compound K, was concentrated and purified by silica column chromatography. The reaction product was isolated as a clear oil (77% yield, 98% purity). The following data were generated to verify the identity of Compound K: ESIMS m / z 417.1 ([M+H]+);1H NMR (400 MHz, CDCl3) δ 6.90 – 6.72 (m, 2H), 6.15 (d, J = 9.1 Hz, 1H), 4.86 – 4.77 (m, 1H), 4.59 (dd, J = 9.1, 2.3 Hz, 1H), 4.27 (d, J = 15.9 Hz, 1H), 4.06 – 3.89 (m, 2H), 3.76 (s, 3H), 3.28 (s, 3H), 2.70 (dd, J = 14.5, 4.5 Hz, 1H), 2.53 (ddd, J = 16.7, 9.5, 7.0 Hz, 1H), 2.42 (ddd, J = 16.9, 9.6, 5.8 Hz, 1H), 2.36 – 2.24 (m, 2H), 1.85 (ddt, J = 13.0, 10.1, 5.3 Hz, 1H), 1.15 (d, J = 6.3 Hz, 3H);19F NMR (376 MHz, CDCl3) δ -114.33 – -114.40 (m), -132.92 – -133.00 (m), -148.57 – -148.68 (m).

[0007] Compound L: O-methyl-N-(2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2- yl)acetyl)-L-threonine Compound L Compound N was prepared as follows: In a 25 mL reaction vial charged with a magnetic stir bar were added lithium hydroxide (0.054 g, 2.3 mmol) and methyl O-methyl-N- (2-((S)-5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl)acetyl)-L-threoninate (0.19 g, 0.45 mmol) in a THF (1.4 mL) / water (0.45 mL) solvent mixture. The reaction was stirred at 20 °C for 18 h. The reaction mixture was acidified with 1 M HCl (2.5 mL), then diluted with water (3 mL) and brine (3 mL). The aqueous layer was extracted with CH2Cl2 (10 mL x 5). The combined organic phase layers were passed through a phase separator and concentrated. The reaction product, Compound N, was isolated as a white solid (92% yield, 97% purity). The following data were generated to verify the identity of Compound N: ESIMS m / z 403.1 ([M+H]+);1H NMR (400 MHz, DMSO-d6) δ 12.71 (s, 1H), 8.21 (d, J = 9.0 Hz, 1H), 7.45 (dddd, J = 11.2, 9.0, 6.1, 3.2 Hz, 1H), 6.95 (qd, J = 5.1, 2.4 Hz, 1H), 4.70 (d, J = 16.1 Hz, 1H), 4.37 (dd, J = 9.0, 3.1 Hz, 1H), 4.27 (d, J = 16.2 Hz, 1H), 3.90 – 3.75 (m, 2H), 3.22 (s, 3H), 2.63 (dd, J = 13.6, 4.6 Hz, 1H), 2.43 – 2.32 (m, 2H), 2.25 (ddd, J = 16.7, 9.6, 5.1 Hz, 1H), 2.16 – 2.05 (m, 1H), 1.85 – 1.73 (m, 1H), 1.04 (d, J = 6.3 Hz, 3H);19F NMR (376 MHz, DMSO-d6) δ -114.89 (dd, J = 15.2, 4.0 Hz), -134.49 (dd, J = 22.0, 3.8 Hz), -148.02 (dd, J = 22.3, 15.5 Hz).

[0008] Compound M: Methyl (2-((S)-1-(2,3-difluorobenzyl)-5-thioxopyrrolidin-2- yl)ethanethioyl)-L-valinate Compound M Compound M was prepared as follows: Lawesson reagent (0.58 g, 1.4 mmol) was added to a stirred solution of methyl (2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetyl)-L-valinate (0.50 g, 1.3 mmol) in dry toluene (15 mL) at room temperature. The resulting yellow suspension was stirred at 65 °C for 2 h, and the progress of the reaction was monitored by ultra performance liquid chromatography (UPLC). The mono / bis thiolactam formation in a 4:1 ratio was observed. The reaction mixture was left stirring overnight. After 16 h, 80% of the desired product, Compound M, was observed by liquid chromatography–mass spectrometry (LCMS). The resulting reaction mixture was purified using flash column chromatography with 0%-100% acetone / hexanes and evaporative light scattering detector (ELSD) detection. The major ELSD peak was collected, concentrated, and dried to provide Compound M. The reaction product was isolated as a colorless oil (50% yield, 95% purity). The following data were generated to verify the identity of Compound M: ESIMS m / z 415.0 ([M+H]+);1H NMR (400 MHz, CDCl3) δ 7.66 (d, J = 8.1 Hz, 1H), 7.22 – 6.82 (m, 3H), 5.60 (d, J = 15.2 Hz, 1H), 5.12 (dd, J = 8.1, 4.6 Hz, 1H), 4.66 (d, J = 15.3 Hz, 1H), 4.53 (tt, J = 8.5, 4.2 Hz, 1H), 3.78 (s, 3H), 3.24 – 2.93 (m, 3H), 2.69 (dd, J = 13.6, 9.2 Hz, 1H), 2.48 – 2.14 (m, 2H), 1.92 (ddt, J = 13.1, 8.9, 4.6 Hz, 1H), 1.03 (d, J = 7.0 Hz, 3H), 0.95 (d, J = 6.9 Hz, 3H);19F NMR (471 MHz, CDCl3) δ -137.30 (ddd, J = 21.1, 10.1, 5.0 Hz), -143.22 (d, J = 20.9 Hz). Compound N: Methyl (2-((S)-1-(2,3-difluorobenzyl)-5-thioxopyrrolidin-2-yl)acetyl)- L-valinate Compound N Compound N was prepared as follows: Lawesson reagent (0.29 g, 0.72 mmol) was added to a stirred solution of methyl (2-((S)-1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetyl)-L-valinate (0.50 g, 1.3 mmol) in dry toluene (13 mL) at room temperature. The reaction mixture was left stirring overnight. After 16 h, 90% of the desired product, Compound N, was observed by UPLC. The resulting reaction mixture was purified by flash column chromatography with 0%-100% acetone / hexanes and ELSD detection. The major ELSD peak was collected, concentrated, and dried to provide Compound N. The reaction product was isolated as a colorless oil (56% yield, 90% purity). The following data were generated to confirm the identity of Compound N: ESIMS m / z 399.0 ([M+H]+);1H NMR (500 MHz, CDCl3) δ 7.20 – 6.96 (m, 3H), 5.93 (d, J = 8.7 Hz, 1H), 5.72 – 5.52 (m, 1H), 4.63 (d, J = 15.4 Hz, 1H), 4.54 (dd, J = 8.6, 4.8 Hz, 1H), 4.30 (tt, J = 8.7, 4.3 Hz, 1H), 3.76 (s, 3H), 3.21 – 2.99 (m, 2H), 2.74 (dd, J = 14.6, 4.3 Hz, 1H), 2.42 – 2.23 (m, 2H), 2.16 (pd, J = 6.9, 4.8 Hz, 1H), 1.88 (ddt, J = 13.5, 9.2, 5.0 Hz, 1H), 0.93 (d, J = 6.8 Hz, 3H), 0.90 (d, J = 6.9 Hz, 3H);19F NMR (471 MHz, CDCl3) δ -137.34 (d, J = 24.1 Hz), -143.55 (d, J = 20.3 Hz). Compound O: (2-((S)-1-(2,3-difluorobenzyl)-5-thioxopyrrolidin-2-yl)acetyl)-L-valine Compound O Compound O was prepared as follows: In a 25 mL reaction vial charged with a magnetic stir bar was added methyl (2-((S)-1-(2,3-difluorobenzyl)-5-thioxopyrrolidin-2- yl)acetyl)-L-valinate (0.11 g, 0.28 mmol) in a THF (1.1 mL) / water (0.37 mL) solvent mixture. Lithium hydroxide (9.9 mg, 0.41 mmol) was added and the reaction mixture was stirred at 20 °C for 18 h. The THF layer of the reaction mixture was evaporated, and the remaining reaction mixture was acidified with 1 M HCl (1.5 mL) to pH 5. The acidified mixture was extracted with ethyl acetate (5 mL x 3). The combined organic layers were dried over sodium sulfate, filtered, and concentrated to give the reaction product, Compound O. The reaction product was isolated as a white solid (63% yield, 90% purity). The following data were generated to confirm the identity of Compound O: ESIMS m / z 385.0 ([M+H]+);1H NMR (400 MHz, DMSO-d6) δ 12.60 (s, 1H), 8.21 (dd, J = 17.5, 8.6 Hz, 1H), 7.38 (dtd, J = 10.2, 8.2, 1.7 Hz, 1H), 7.19 (dtd, J = 8.2, 5.8, 2.5 Hz, 1H), 7.07 (t, J = 7.0 Hz, 1H), 5.42 (d, J = 15.7 Hz, 1H), 4.70 (d, J = 15.9 Hz, 1H), 4.29 – 4.13 (m, 2H), 3.08 – 2.85 (m, 2H), 2.68 (dd, J = 13.9, 4.5 Hz, 1H), 2.52 – 2.44 (m, 1H), 2.31 – 2.09 (m, 1H), 2.05 (dq, J = 13.3, 6.9 Hz, 1H), 1.94 – 1.74 (m, 1H), 0.86 (dd, J = 6.8, 3.1 Hz, 6H). Compound P: Methyl (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5- thioxopyrrolidin-2-yl)ethanethioamido)propanoate Compound P Compound P was prepared as follows: Lawesson reagent (0.77 g, 1.9 mmol) was added to a stirred solution of methyl (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5- oxopyrrolidin-2-yl)acetamido)propanoate (1.0 g, 2.5 mmol) in dry toluene (25 mL) at room temperature. The resulting yellow suspension was stirred at 40 °C for 24 h, and the progress of the reaction was monitored by ultra performance liquid chromatography (UPLC). The mono / bis thiolactam formation in a 1.6:1 ratio was observed. The resulting reaction mixture was purified using flash column chromatography with 0%-100% acetone / hexanes and evaporative light scattering detector (ELSD) detection. The major ELSD peak was collected, concentrated, and dried to provide Compound P. The reaction product was isolated as a colorless oil (28% yield, 95% purity). The following data were generated to verify the identity of Compound P: ESIMS m / z 427 ([M+H]+);1H NMR (400 MHz, CDCl3) δ 7.09 (dt, J = 23.3, 7.9 Hz, 3H), 6.12 (d, J = 7.8 Hz, 1H), 5.59 (d, J = 15.4 Hz, 1H), 4.74 – 4.50 (m, 2H), 4.30 (dt, J = 8.6, 4.3 Hz, 1H), 3.76 (s, 3H), 3.25 – 2.93 (m, 2H), 2.72 (dd, J = 14.6, 4.4 Hz, 1H), 2.32 (dt, J = 13.0, 8.8 Hz, 2H), 2.04 – 1.79 (m, 1H), 1.70 (qt, J = 14.0, 6.4 Hz, 2H), 0.63 (d, J = 7.0 Hz, 1H), 0.48 (dd, J = 8.2, 2.8 Hz, 2H), 0.06 (t, J = 3.8 Hz, 2H). Compound Q: Methyl (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5- thioxopyrrolidin-2-yl)acetamido)propanoate Compound Q Compound Q was prepared as follows: Lawesson reagent (0.71 g, 1.8 mmol) was added to a stirred solution of methyl (S)-3-cyclopropyl-2-(2-((S)-1-(2,3-difluorobenzyl)-5- oxopyrrolidin-2-yl)acetamido)propanoate (1.3 g, 3.4 mmol) in dry toluene (25 mL) at room temperature. The reaction mixture was left stirring for 48 h. The resulting reaction mixture was purified by flash column chromatography with 0%-100% acetone / hexanes and ELSD detection. The major ELSD peak was collected, concentrated, and dried to provide Compound Q. The reaction product was isolated as a colorless oil (65% yield, 90% purity). The following data were generated to confirm the identity of Compound Q: ESIMS m / z 411 ([M+H]+);1H NMR (500 MHz, CDCl3) δ 7.20 – 6.98 (m, 3H), 6.24 – 6.07 (m, 1H), 5.59 (d, J = 15.4 Hz, 1H), 4.67-4.59 (m, 2H), 4.30 (tt, J = 8.6, 4.3 Hz, 1H), 3.76 (s, 3H), 3.22 – 3.01 (m, 2H), 2.72 (dd, J = 14.7, 4.4 Hz, 1H), 2.40 – 2.23 (m, 2H), 1.90 (ddt, J = 13.5, 9.3, 4.9 Hz, 1H), 1.80 – 1.58 (m, 2H), 0.63 (dtt, J = 14.8, 7.2, 3.7 Hz, 1H), 0.52 – 0.43 (m, 2H), 0.11 – 0.02 (m, 2H). 4. Compositions The present disclosure also includes compositions containing the substituted 5- membered ring molecule herbicides disclosed herein. A composition is a mixture comprising at least one substituted 5-membered ring molecule herbicide or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof) and further comprising other additives used to enhance the properties or effectiveness of the mixture in some way. Exemplary additives include but are not limited to adjuvants, safeners, carriers, and combinations thereof. Compositions may be in various physical states, including but not limited to as solutions, emulsions, suspensions, granules, powders, and other such states. 1. Adjuvants In some aspects, the additive includes an agriculturally acceptable adjuvant. Exemplary agriculturally acceptable adjuvants include, but are not limited to, antifreeze agents, antifoam agents, compatibilizing agents, sequestering agents, neutralizing agents and buffers, corrosion inhibitors, colorants, odorants, penetration aids, wetting agents, spreading agents, dispersing agents, thickening agents, freeze point depressants, antimicrobial agents, crop oil, adhesives (for instance, for use in seed formulations), surfactants, protective colloids, emulsifiers, tackifiers, and mixtures thereof. Exemplary agriculturally acceptable adjuvants include, but are not limited to, crop oil concentrates (e.g., 85% mineral oil + 15% emulsifiers); nonylphenol ethoxylates; benzylcocoalkyldimethyl quaternary ammonium salts; blends of petroleum hydrocarbon, alkyl esters, organic acids, and anionic surfactants; C9-C11alkylpolyglycoside; phosphate alcohol ethoxylates; natural primary alcohol (C12-C16) ethoxylate; di-sec-butylphenol EO-PO block copolymers; polysiloxane-methyl cap; nonylphenol ethoxylate+urea ammonium nitrates; emulsified methylated seed oils; tridecyl alcohol (synthetic) ethoxylates (e.g., 8 EO); tallow amine ethoxylates (e.g., 15 EO); and PEG(400) dioleate-99. Exemplary surfactants (e.g., wetting agents, tackifiers, dispersants, emulsifiers) include, but are not limited to: the alkali metal salts, alkaline earth metal salts and ammonium salts of fatty acids or of aromatic sulfonic acids (e.g., lignosulfonic acids, phenolsulfonic acids, naphthalenesulfonic acids, and dibutylnaphthalenesulfonic acid); alkyl- and alkylarylsulfonates; alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates; salts of sulfated hexa-, hepta- and octadecanols; salts of fatty alcohol glycol ethers; condensates of sulfonated naphthalene and its derivatives with formaldehyde; condensates of naphthalene or of the naphthalene sulfonic acids with phenol and formaldehyde; polyoxyethylene octylphenol ether; ethoxylated isooctyl-, octyl- or nonylphenol, alkylphenyl or tributylphenyl polyglycol ether; alkyl aryl polyether alcohols; isotridecyl alcohol; fatty alcohol / ethylene oxide condensates; ethoxylated castor oil; polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers; lauryl alcohol polyglycol ether acetate; sorbitol esters; lignosulfite waste liquors and proteins; denatured proteins, polysaccharides (e.g., methylcellulose); hydrophobically modified starches; and polyvinyl alcohol, polycarboxylates, polyalkoxylates, polyvinyl amines, polyethyleneimine, polyvinylpyrrolidone, and copolymers thereof. Exemplary thickeners include, but are not limited to, polysaccharides (e.g., xanthan gum), organic and inorganic sheet minerals, and mixtures thereof. Exemplary antifoam agents include, but are not limited to, silicone emulsions, long- chain alcohols, fatty acids, fatty acid salts, organofluorine compounds, and mixtures thereof. Exemplary antimicrobial agents include, but are not limited to, bactericides based on dichlorophen and benzyl alcohol hemiformal; isothiazolinone derivatives, such as alkylisothiazolinones and benzisothiazolinones; and mixtures thereof. Exemplary antifreeze agents, include, but are not limited to ethylene glycol, propylene glycol, urea, glycerol, and mixtures thereof. Exemplary colorants include, but are not limited to, the dyes known under the names Rhodamine B, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1, pigment blue 80, pigment yellow 1, pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48:1, pigment red 57:1, pigment red 53:1, pigment orange 43, pigment orange 34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, acid red 51, acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108, and mixtures thereof. Exemplary adhesives include, but are not limited to, polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, tylose, and mixtures thereof. 2. Safeners In some aspects, the additive is a safener. Safeners are compounds leading to better crop plant compatibility when applied with a herbicide. In some aspects, the safener itself is herbicidally active. In some aspects, the safener acts as an antidote or antagonist in the crop plants and can protect the crop plants from damage that might otherwise occur from an applied herbicide. Exemplary safeners include, but are not limited to, AD-67 (MON 4660), benoxacor, benthiocarb, brassinolide, cloquintocet, cloquintocet-mexyl, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, disulfoton, fenchlorazole, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, harpin proteins, isoxadifen- ethyl, jiecaowan, jiecaoxi, mefenpyr, mefenpyr-diethyl, mephenate, naphthalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro [4.5]- decane, oxabetrinil, R29148, and N-phenyl-sulfonylbenzoic acid amides, agriculturally acceptable salts as well as thereof and, provided they have a carboxyl group, their agriculturally acceptable derivatives. In some aspects, the safener can be cloquintocet or an ester or salt thereof, such as cloquintocet-mexyl. In some aspects, the safener can be mefenpyr or an ester or salt thereof, such as mefenpyr-diethyl. In some aspects, the safener is employed in rice, cereal, or maize. For example, mefenpyr or cloquintocet can be used to antagonize harmful effects of the compositions on rice, row crops, and cereals. 3. Carriers In some aspects, the additive includes a carrier. In some aspects, the additive includes a liquid or solid carrier. In some aspects, the additive includes an organic or inorganic carrier. Exemplary liquid carriers include, but are not limited to: water; petroleum fractions or hydrocarbons such as mineral oil, aromatic solvents, paraffinic oils, and the like; vegetable oils such as soybean oil, rapeseed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil and the like; esters of the above vegetable oils; esters of monoalcohols or dihydric, trihydric, or other lower polyalcohols (4-6 hydroxy containing), such as 2-ethyl hexyl stearate, n-butyl oleate, isopropyl myristate, propylene glycol dioleate, di-octyl succinate, di-butyl adipate, di-octyl phthalate and the like; esters of mono, di and polycarboxylic acids and the like; toluene; xylene; petroleum naphtha; crop oil; acetone; methyl ethyl ketone; cyclohexanone; trichloroethylene; perchloroethylene; ethyl acetate; amyl acetate; butyl acetate; propylene glycol monomethyl ether and diethylene glycol monomethyl ether; methyl alcohol; ethyl alcohol; isopropyl alcohol; amyl alcohol; ethylene glycol; propylene glycol; glycerin; N-methyl-2-pyrrolidinone; N;N-dimethyl alkylamides; dimethyl sulfoxide; and liquid fertilizers, as well as mixtures thereof. Exemplary solid carriers include, but are not limited to: silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, pyrophyllite clay, attapulgus clay, kieselguhr, calcium carbonate, bentonite clay, Fuller's earth, cottonseed hulls, wheat flour, soybean flour, pumice, wood flour, walnut shell flour, lignin, ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders, and mixtures thereof. 4. Physical States In some aspects, the compositions comprising the substituted 5-membered ring molecule herbicide may be present in suspended, emulsified, dissolved, or solid form. Exemplary compositions include, but are not limited to, aqueous solutions, aqueous suspensions, aqueous dispersions, aqueous emulsions, aqueous microemulsions, aqueous suspo-emulsions, oil solutions, oil suspensions, oil dispersions, oil emulsions, oil microemulsions, oil suspo-emulsions, self-emulsifying formulations, gels, pastes, powders, dusts, granules, and materials for spreading. In some aspects, the substituted 5-membered ring molecule herbicide is in an aqueous solution that can be diluted before use. In various aspects, the substituted 5-membered ring molecule herbicide may be provided as a high-strength formulation such as a concentrate. In some aspects, the concentrate is stable and retains potency during storage and shipping. In various aspects, the concentrate is a clear, homogeneous liquid that is stable at temperatures of 54 °C or greater. In some aspects, the concentrate does not exhibit any precipitation of solids at temperatures of 10 °C or higher. In some aspects, the concentrate does not exhibit separation, precipitation, or crystallization of any components at low temperatures. For example, the concentrate remains a clear solution at temperatures below 0 °C (e.g., below -5 °C, below -10 °C, below -15 °C). In some aspects, the concentrate exhibits a viscosity of less than 50 centipoise (50 megapascals), even at temperatures as low as 5 °C. In some aspects, the concentrate does not exhibit separation, precipitation, or crystallization of any components during storage for a period of 2 weeks or greater (e.g., 4 weeks, 6 weeks, 8 weeks, 3 months, 6 months, 9 months, or 12 months or greater). In some aspects, emulsions, gels, pastes, or oil dispersions can be prepared by homogenizing the substituted 5-membered ring molecule herbicide in water with a wetting agent, tackifier, dispersant, or emulsifier. In some aspects, concentrates suitable for dilution with water can be prepared, comprising the substituted 5-membered ring molecule herbicide, a wetting agent, a tackifier, and a dispersant or emulsifier. In some aspects, powders, materials for spreading, or dusts can be prepared by mixing or concomitant grinding the substituted 5-membered ring molecule herbicide and optionally other additives with a solid carrier. In some aspects, granules (e.g., coated granules, impregnated granules and homogeneous granules) can be prepared by binding the substituted 5-membered ring molecule herbicide to solid carriers. In some aspects, the compositions comprise, by total weight of the composition, from about 0.01% to about 99% of the substituted 5-membered ring molecule herbicide, including about 0.025%, 0.05%, 0.075%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 7.5%, 8%, 9%, 10%, 12.5%, 15%, 17.5%, 20%, 22.5%, 25%, 27.5%, 30%, 32.5%, 35%, 37.5%, 40%, 42.5%, 45%, 47.5%, 50%, 52.5%, 55%, 57.5%, 60%, 62.5%, 65%, 67.5%, 70%, 72.5%, 75%, 77.5%, 80%, 82.5%, 85%, 87.5%, 90%, 92.5%, 95%, 97.5%, or 98% of the substituted 5-membered ring molecule herbicide by total weight of the composition, or within any range defined between any two of the forgoing values, such as between about 1% to about 97%, between about 10% to about 90%, between about 20% to about 45%, and about 25% to about 50% based on the total weight of the composition. Concentrates can be diluted with an inert carrier, such as water, prior to application. The diluted compositions applied to undesirable vegetation or the locus of undesirable vegetation can contain from 0.0006 to 8.0 weight percent (wt %) of the total amount of the substituted 5- membered ring molecule herbicide (e.g., from 0.001 to 5.0 wt %), based on the total weight of the diluted composition. 5. Methods of Use The substituted 5-membered ring molecules or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof) disclosed herein can be formulated into compositions and applied in any known technique for applying herbicides. Exemplary application techniques include, but are not limited to, spraying, atomizing, dusting, sprinkling, spreading, or direct application. The method of application can vary depending on the intended purpose. In some aspects, the method of application can be chosen to ensure the finest possible distribution of the compositions disclosed herein. In some aspects, a method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with or applying to the soil or water to prevent the emergence or growth of vegetation any of the compositions is disclosed herein. The compositions containing a substituted 5-membered ring molecule disclosed herein can be applied pre-emergence (before the emergence of undesirable vegetation) or post- emergence (e.g., during and / or after emergence of the undesirable vegetation). In some aspects, the composition is applied postemergence to the undesirable vegetation. When the compositions are used in crops, the compositions can be applied after seeding and before or after the emergence of the crop plants. In some aspects, the compositions disclosed herein show good crop tolerance even when the crop has already emerged and can be applied during or after the emergence of the crop plants. In some aspects, when the compositions are used in crops, the compositions can be applied before seeding of the crop plants. In some aspects, the compositions disclosed herein are applied to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation by spraying (e.g., foliar spraying). In some aspects, the spraying techniques use, for example, water as carrier and spray volume rates of from 2 liters per hectare (L / ha) to 2000 L / ha (e.g., from 10–1000 L / ha or from 50–500 L / ha). In some aspects, the compositions disclosed herein are applied by the low-volume or the ultra-low-volume method, wherein the application is in the form of micro granules. In some aspects, wherein the compositions disclosed herein are less well tolerated by certain crop plants, the compositions can be applied with the aid of the spray apparatus in such a way that they come into little contact, if any, with the leaves of the sensitive crop plants while reaching the leaves of undesirable vegetation that grows underneath or on the bare soil (e.g., post-directed or lay-by). In some aspects, the compositions disclosed herein can be applied as dry compositions (e.g., granules, powders, or dusts). In some aspects, wherein the undesirable vegetation is treated post-emergence, the compositions disclosed herein are applied by foliar application. In some aspects, herbicidal activity is exhibited by the compounds of the mixture when they are applied directly to the plant or to the locus of the plant at any stage of growth or before planting or emergence. The effect observed can depend upon the type of undesirable vegetation to be controlled, the stage of growth of the undesirable vegetation, the application parameters of dilution and spray drop size, the particle size of solid components, the environmental conditions at the time of use, the specific compound employed, the specific adjuvants and carriers employed, the soil type, and the like, as well as the amount of chemical applied. In some aspects, these and other factors can be adjusted to promote non-selective or selective herbicidal action. The compositions and methods disclosed herein can be used to control undesirable vegetation in a variety of applications. The compositions and methods disclosed herein can be used for controlling undesirable vegetation in areas including, but not limited to, farmland, turfgrass, pastures, grasslands, rangelands, fallow land, rights-of-way, aquatic settings, tree and vine, wildlife management areas, or rangeland. In some aspects, the undesirable vegetation is controlled in a row crop. Exemplary crops include, but are not limited to, wheat, barley, triticale, rye, teff, oats, maize, cotton, soy, canola, pulses, sunflower, sugar beet, sorghum, rice, millet, sugarcane, and range land (e.g., pasture grasses). In some aspects, the compositions and methods disclosed herein can be used for controlling undesirable vegetation in maize, soy, canola, cotton, pulses, sunflower, sugar beet, wheat, barley, rice, sorghum, millet, oats, or combinations thereof. In some aspects, the compositions and methods disclosed herein can be used in industrial vegetation management (IVM) or for utility, pipeline, roadside, and railroad rights−of−way applications. In some aspects, the compositions and methods disclosed herein can also be used in forestry (e.g., for site preparation or for combating undesirable vegetation in plantation forests). In some aspects, the compositions and methods disclosed herein can be used to control undesirable vegetation in conservation reserve program lands (CRP), trees, vines, grasslands, and grasses grown for seeds. In some aspects, the compositions and methods disclosed herein can be used on lawns (e.g., residential, industrial, and institutional), golf courses, parks, cemeteries, athletic fields, and sod farms. The compositions and methods disclosed herein can also be used in crop plants that are resistant to, for instance, herbicides, insecticides, fungicides, pathogens, insects, or combinations thereof. In some aspects, the compositions and methods disclosed herein can be used in crop plants that are resistant to one or more herbicides because of genetic engineering or breeding. In some aspects, the compositions and methods disclosed herein can be used in crop plants that are resistant to one or more pathogens such as plant pathogenic fungi owing to genetic engineering or breeding. In some aspects, the compositions and methods disclosed herein can be used in crop plants that are resistant to attack by insects owing to genetic engineering or breeding. Exemplary resistant crops include, but are not limited to, crops that are resistant to photosystem II inhibitors, or crop plants that, owing to introduction of the gene for Bacillus thuringiensis (or Bt) toxin by genetic modification, are resistant to attack by certain insects. In some aspects, the compositions and methods described herein can be used in conjunction with glyphosate, glufosinate, dicamba, phenoxy auxins, pyridyloxy auxins, aryloxyphenoxypropionates, acetyl CoA carboxylase (ACCase) inhibitors, imidazolinones, acetolactate synthase (ALS) inhibitors, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors, protoporphyrinogen oxidase (PROTOX) inhibitors, triazines, and bromoxynil to control vegetation in crops tolerant to glyphosate, glufosinate, dicamba, phenoxy auxins, pyridyloxy auxins, aryloxyphenoxypropionates, ACCase inhibitors, imidazolinones, synthetic auxin herbicides, HPPD inhibitors, PROTOX inhibitors, triazines, bromoxynil, or combinations thereof. In some aspects, the undesirable vegetation is controlled in glyphosate, glufosinate, dicamba, phenoxy auxins, pyridyloxy auxins, aryloxyphenoxypropionates, ACCase inhibitors, synthetic auxin herbicide, HPPD inhibitors, PROTOX inhibitors, triazines, and bromoxynil tolerant crops possessing single, multiple or stacked traits conferring tolerance to single or multiple chemistries and / or multiple modes of action. In some aspects, the undesirable vegetation can be controlled in a crop that is ACCase-tolerant, ALStolerant, or a combination thereof. In some aspects, the compositions described herein and other complementary herbicides are applied at the same time, either as a combination composition or as a tank mix, or as sequential applications. The compositions and methods may be used in controlling undesirable vegetation in crops possessing agronomic stress tolerance (including but not limited to drought, cold, heat, salt, water, nutrient, fertility, pH), pest tolerance (including but not limited to insects, fungi, and pathogens), and crop improvement traits (including but not limited to yield; protein, carbohydrate, or oil content; protein, carbohydrate, or oil composition; plant stature and plant architecture). The compounds and compositions described herein may be used to control plant species described, but not limited to, weeds species found in Randall, R.P. (2017). A Global Compendium of Weeds. 3rd Edition. Perth, Western Australia. In some aspects, the compositions disclosed herein can be used for controlling undesirable vegetation including grasses, broadleaf weeds, sedge weeds, and combinations thereof. In some aspects, the compositions disclosed herein can be used for controlling undesirable vegetation including, but not limited to, Acanthospermum species, Aegilops species, Agrostis species, Alopecurus species, Ambrosia species, Anthemis species, Apera species, Amaranthus species, Avena species, Brachiaria species, Bromus species, Chenopodium species, Cenchrus species, Cirsium species, Commelina species, Cyperus species, Datura species, Digitaria species, Echinochloa species, Eleusine species, Atriplex species, Brassica species, Convolvulus species, Conyza species, Cassia species, Euphorbia species, Geranium species, Galinsoga species, Ipomea species, Lamium species, Leptochloa species, Lolium species, Monochoria species, Malva species, Matricaria species, Panicum species, Phalaris species Polygonum species, Prosopis species, Rumex species, Setaria species, Sida species, Sisymbrium species, Solanum species, Sorghum species, Trifolium species, Xanthium species, Veronica species, and Viola species. In some aspects, the undesired vegetation includes blackgrass (Alopecurus myosuroides Huds.), wild oat (Avena fatua), barnyard grass (Echinochloa crus-galli) common chickweed (Stellaria media), velvetleaf (Abutilon theophrasti), hemp sesbania (Sesbania exaltata Cory), Anoda cristata, Bidens pilosa, Brassica kaber, shepherd’s purse (Capsella bursa-pastoris), cornflower (Centaurea cyanus or Cyanus segetum), hempnettle (Galeopsis tetrahit), cleavers (Galium aparine), common sunflower (Helianthus annuus), Desmodium tortuosum, Italian ryegrass (Lolium multiflorum), kochia (Kochia scoparia), Medicago arabica, Mercurialis annua, Myosotis arvensis, common poppy (Papaver rhoeas), Raphanus raphanistrum, broad- leaf dock (Rumex obtusifolius), Russian thistle (Salsola kali), wild mustard (Sinapis arvensis), Sonchus arvensis, Thlaspi arvense, Tagetes minuta, Richardia brasiliensis, Plantago major, Plantago lanceolata, bird’seye speedwell (Veronica persica), pigweed (Amaranthus retroflexus), winter rape (Brassica napus), lambsquarters (Chenopodium album), Canadian thistle (Cirsium arvense), nutsedge (Cyperus esculentus), poinsettia (Euphorbia heterophylla), prickly lettuce (Lactuca serriola), purple deadnettle (Lamium purpureum), wild chamomile (Matricaria chamomilla), false chamomile (Matricaria inodora), field chamomile (Anthemis arvensis), common buckwheat (Fagopyrum esculentum), wild buckwheat (Polygonum convulvus), giant foxtail (Setaria faberi), green foxtail (Setaria viridis), yellow foxtail (Setaria pumila) common sorghum (Sorghum vulgare), wild pansy (Viola tricolor), or combinations thereof. The compositions described herein can be used to control herbicide resistant or tolerant weeds. The methods employing the compositions described herein may also be employed to control herbicide resistant or tolerant weeds. Exemplary resistant or tolerant weeds include, but are not limited to, biotypes resistant or tolerant to acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates, pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylates, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums, such as paraquat and diquat), 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase inhibitors (e.g., glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bilanafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines), mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PROTOX) inhibitors (e.g., diphenylethers, N- phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidinediones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones, pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., callistemones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes of action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals. Exemplary resistant or tolerant weeds include, but are not limited to, biotypes with resistance or tolerance to multiple herbicides, biotypes with resistance or tolerance to multiple chemical classes, biotypes with resistance or tolerance to multiple herbicide modes of action, and biotypes with multiple resistance or tolerance mechanisms (e.g., target site resistance or metabolic resistance). By way of non-limiting illustration, examples of some aspects of the present disclosure are given below. Parts and percentages are on a per weight basis unless otherwise indicated. Examples The details of the compositions and the crops tested are specified in the following Examples. EVALUATION OF PESTICIDAL ACTIVITY As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Exemplified below are exemplification of various types of herbicidal activity, both pre-emergent and post- emergent herbicidal activity. In Tables 5A-5C are select post-emergent and pre-emergent herbicidal activity for some compounds on various weeds and crops. The following Table 3 lists the plants being evaluated with the various substituted 5-membered ring pesticides at the time of application for the results exemplified in Table 5A and 5B, shown in FIGs.1A and 1B respectively, and the pre-emergent control exemplified in Table 5C in FIG.1C. Also shown are select lists of plants for data represented in FIGs 2-18B, Tables 6A- 22B, which include mixture data of the substituted 5-membered rings with other herbicides and / or safeners and mixture data. Also included in FIGs. 18A-18B are some of the disclosed additional substituted 5-membered rings (shown below in Table 4) and other herbicides. Table 1: Plant Species Used in Evaluations

[0009] The following methods describe the various methods used to analyze pesticidal activity on various crops and weeds shown in FIGs.1-18B. METHOD 1: POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted in plastic pot with 64 square centimeter (cm2) surface area filled with soil-less media planting mix containing PRO-MIX®BX (Premier Tech Horticulture, Quakertown, PA, USA) and PROFILE®GREENS GRADE™ (Profile Products LLC, Buffalo Grove, IL, USA) at pH of 5.2 to 6.2 and a minimum of 50% organic matter content. Echinochloa crus-galli (barnyard grass) and Setaria faberi (giant foxtail) were planted together 11 days prior to application. In a separate pot Alopecurus myosuroides (blackgrass) and Avena fatua (wild oat) was planted together and propagated 14 and 11 days prior to application respectively. Ipomea hederacea (ivyleaf morningglory) and Helianthus annuus (sunflower) were planted in a separate pot, 8 days prior to application. Plants were grown in a greenhouse set to 23 °C day and 22 °C night temperature regimen with a 16 hour photoperiod for the propagation period and returned to the same conditions after treatment. Plants were sub-irrigated as needed with water containing Jack’s Professional 15-5- 154 Ca 2Mg fertilizer. Compositions of each exemplified molecule were dissolved in 2.75 mL of formulation solvent containing by volume (59% deionized water, 24% acetone, 15% isopropanol, 0.75% DMSO, 1.5% crop oil concentrate, 0.02% Tergitol 15S-7) to deliver a spray rate of 2000 or 4000 grams of active ingredient per hectare (g ai / h). Samples were vortexed and sonicated if needed to dissolve the compound into solution. Formulated compounds were applied to all six species in 3 pots using a DeVilbiss® compressed air sprayer at 2–4 pounds per square inch (psi), allowed to dry then returned to the greenhouse. After 9-11 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete plant death. Visual assessments of plant injury were made based on growth inhibition, growth reduction, discoloration, leaf deformity and necrosis. METHOD 2: PRE-EMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted into 12.7 cm diameter round plastic pots containing a silt loam mineral soil. Compositions of each exemplified molecule were dissolved in 0.67 mL 97:3 v / v mixture of acetone and DMSO, then further diluted with 2.05 mL of solvent containing 78% D.I. H2O, 20% isopropanol, 2% AgriDex crop oil concentrate and 0.02% Tergitol 15S-7 surfactant. Samples were mixed vigorously (vortexed) and sonicated if needed to bring the compound into solution. Solution was mixed with 15 mL of D.I. H2O and poured evenly over the soil containing potted seeds. The vial was rinsed with an additional 15 mL of D.I. H2O which was again poured over the soil. Treated pots are moved to in a greenhouse with an approximate 16-hour (h) photoperiod and maintained at 23 °C during the day and 22 °C during the night. Pots were kept moist through over-the-top irrigation. After 14 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to no emergence or complete plant death after emergence. Visual assessments of plant injury were made based on growth inhibition, growth reduction, discoloration, leaf deformity and necrosis. METHOD 3: POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted in plastic pot with 64 square centimeter (cm2) surface area filled with soil-less media planting mix containing PRO-MIX®BX (Premier Tech Horticulture, Quakertown, PA, USA) and PROFILE®GREENS GRADE™ (Profile Products LLC, Buffalo Grove, IL, USA) at pH of 5.2 to 6.2 and a minimum of 50% organic matter content. In some aspects or embodiments, to help ensure good germination and healthy plants, a fungicide treatment and / or other chemical or physical treatment was applied. The plants were grown for 7–36 days (d) in a greenhouse with an approximate 16-hour (h) photoperiod and set to 23 °C day and 22 °C night temperature regimen. Plants were sub- irrigated as needed with water containing Jack’s Professional 15-5-15 4 Ca 2Mg fertilizer. Supplemental lighting was provided as necessary. The plants were employed for testing when they reached the second or third true leaf stage. Compositions of each exemplified molecule was weighed to a known amount, determined by the highest rate to be tested, by placing in a 25 mL glass vial and was dissolved in 4 mL of a 97:3 v / v mixture of acetone and DMSO to obtain concentrated stock solutions. If the test compound did not dissolve readily, the mixture was warmed and / or sonicated. The concentrated stock solutions obtained were diluted with 20 mL of an aqueous mixture containing acetone, water, isopropyl alcohol, DMSO, AgriDex crop oil concentrate, and Tergitol 15S-7 surfactant in a 48.5:39:10:1.5:1.0:0.02 v / v ratio to obtain spray solutions at the application rate. Compound requirements are based upon a 12 mL application volume at a rate of 187 liters per hectare (L / ha). The spray solutions were applied to the plant material with an overhead DeVries track sprayer equipped with 8002E nozzles calibrated to deliver 187 L / ha over an application area of 0.503 square meters (m2) at a spray height of 18 inches (43 centimeters (cm)) above the average plant canopy. Control or non-treated plants were sprayed in the same manner with the solvent blank or not treated. All herbicide application rates are given as grams acid equivalent per hectare (g ae / h) or grams active ingredient per hectare (g ai / h). The treated plants and control plants were placed in a greenhouse as described above and watered by subirrigation to prevent removal of the test compound. After 13-15 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete plant death. Visual assessments of plant injury were made based on growth reduction, discoloration, leaf deformity and necrosis. METHOD 4: POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted in plastic pot with 64 square centimeter (cm2) surface area filled with soil-less media planting mix containing PRO-MIX®BX (Premier Tech Horticulture, Quakertown, PA, USA) and PROFILE®GREENS GRADE™ (Profile Products LLC, Buffalo Grove, IL, USA) at pH of 5.2 to 6.2 and a minimum of 50% organic matter content. In some aspects or embodiments, to help ensure good germination and healthy plants, a fungicide treatment and / or other chemical or physical treatment was applied. Prior to treatment, plants were grown in a chamber for 4-13 days (days) with a 16-hour (h) photoperiod and set to 25 °C or 28 °C day or 22 °C or 24 °C night temperature regimen dependent on species. Plants were delivered to a greenhouse with an approximate 14-hour (h) photoperiod and set to 27 °C day and 24 °C night temperature regimen for the duration of the experiment. Plants were sub-irrigated as needed with water containing Jack’s Professional 15- 5-154 Ca 2Mg fertilizer. Supplemental lighting was provided as necessary. The plants were employed for testing when they reached the second or third true leaf stage. Emulsifiable concentrates of 5-membered ring molecules were prepared at 100 grams active ingredient per liter (g ai / L). An aliquot of each emulsifiable concentrate was placed in a 25 mL glass vial and diluted with an aqueous mixture of 1.0% (v / v) Dyne-Amic®(Helena®) to obtain spray solutions based upon a 12 mL application volume at a rate of 187 liters per hectare (L / ha). Spray solutions of the herbicide combinations (Compound A or Compound B) plus a second herbicide were prepared by adding weighed amounts or aliquots of the second herbicide to the spray solutions of Compound A or Compound B to form 12-mL spray solutions in two-way combinations. The spray solutions were applied to the plant material with an overhead DeVries track sprayer equipped with 8002E nozzles calibrated to deliver 187 L / ha over an application area of 0.503 square meters (m2) at a spray height of 18 inches (43 centimeters (cm)) above the average plant canopy. Control or non-treated plants were sprayed in the same manner with the solvent blank or not treated. All herbicide application rates are given as grams acid equivalent per hectare (g ae / h) or grams active ingredient per hectare (g ai / h). The treated plants and control plants were placed in a greenhouse as described above and watered by subirrigation to prevent removal of the test compound. After 13-15 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete plant death. Visual assessments of plant injury were made based on growth reduction, discoloration, leaf deformity and necrosis. METHOD 5: POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted in plastic pot with 103.2 square centimeter (cm2) surface area filled with soil-less media planting mix containing PRO-MIX®BX (Premier Tech Horticulture, Quakertown, PA, USA) and PROFILE®GREENS GRADE™ (Profile Products LLC, Buffalo Grove, IL, USA) at pH of 5.2 to 6.2 and a minimum of 50% organic matter content. In some aspects or embodiments, to help ensure good germination and healthy plants, a fungicide treatment and / or other chemical or physical treatment was applied. Prior to treatment, plants were grown in a chamber for 5-13 days (days) with a 16-hour (h) photoperiod and set to 24 °C or 28 °C day or 23 °C or 24 °C night temperature regimen dependent on species. Plants were delivered to a greenhouse with an approximate 14-hour (h) photoperiod and set to 28 °C day and 25 °C night temperature regimen for the duration of the experiment. Plants were sub-irrigated as needed with water containing Jack’s Professional 15- 5-154 Ca 2Mg fertilizer. Supplemental lighting was provided as necessary. The plants were employed for testing when they reached the second or third true leaf stage. Emulsifiable concentrates of 5-membered ring molecule were prepared at 100 grams active ingredient per liter (g ai / L). An aliquot of each emulsifiable concentrate was placed in a 25 mL glass vial and diluted with an aqueous mixture of 1.0% (v / v) Dyne-Amic®(Helena®) to obtain spray solutions based upon a 12 mL application volume at a rate of 187 liters per hectare (L / ha). Spray solutions of the herbicide combinations (Compound A or Compound B) plus a second herbicide were prepared by adding weighed amounts or aliquots of the second herbicide to the spray solutions of Compound A or Compound B to form 12-mL spray solutions in two-way combinations. The spray solutions were applied to the plant material with an overhead DeVries track sprayer equipped with 8002E nozzles calibrated to deliver 187 L / ha over an application area of 0.503 square meters (m2) at a spray height of 18 inches (43 centimeters (cm)) above the average plant canopy. Control or non-treated plants were sprayed in the same manner with the solvent blank or not treated. All herbicide application rates are given as grams acid equivalent per hectare (g ae / h) or grams active ingredient per hectare (g ai / h). The treated plants and control plants were returned to a greenhouse as described above and watered by subirrigation to prevent removal of the test compound. After 20-22 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete plant death. Visual assessments of plant injury were made based on growth reduction, discoloration, leaf deformity and necrosis. METHOD 6: POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS Seeds of the desired test plant species were planted in plastic pot with 103.2 square centimeter (cm2) surface area filled with soil-less media planting mix containing PRO-MIX®BX (Premier Tech Horticulture, Quakertown, PA, USA) and PROFILE® GREENS GRADE™ (Profile Products LLC, Buffalo Grove, IL, USA) at pH of 5.2 to 6.2 and a minimum of 50% organic matter content. In some aspects or embodiments, to help ensure good germination and healthy plants, a fungicide treatment and / or other chemical or physical treatment was applied. Prior to treatment, plants were grown in a chamber for 5-13 days (days) with a 16-hour (h) photoperiod and set to 24 °C or 28 °C day or 23 °C or 24 °C night temperature regimen dependent on species. Plants were delivered to a greenhouse with an approximate 14-hour (h) photoperiod and set to 28 °C day and 25 °C night temperature regimen for the duration of the experiment. Plants were sub-irrigated as needed with water containing Jack’s Professional 15- 5-154 Ca 2Mg fertilizer. Supplemental lighting was provided as necessary. The plants were employed for testing when they reached the second or third true leaf stage. Compositions of each the 5-membered ring molecule being evaluated was weighed to a known amount, determined by the highest rate to be tested, by placing in a 25 mL glass vial and was dissolved in 4 mL of a 97:3 v / v mixture of acetone and DMSO to obtain concentrated stock solutions. If the compound did not dissolve readily, the mixture was warmed and / or sonicated. The concentrated stock solutions obtained were diluted with 20 mL of an aqueous mixture containing acetone, water, isopropyl alcohol, DMSO, AgriDex crop oil concentrate, and Tergitol 15S-7 surfactant in a 56.2:32.5:8.3:1.75:1.25:0.02 v / v ratio to obtain spray solutions at the application rate. Spray solutions of the 5-membered ring molecule being evaluated were combined with a second herbicide by adding weighed amounts or aliquots of the second herbicide to the spray solutions of the 5-membered ring molecule being evaluated to form 12-mL spray solutions in two-way combinations. The spray solutions were applied to the plant material with an overhead DeVries track sprayer equipped with 8002E nozzles calibrated to deliver 187 L / ha over an application area of 0.503 square meters (m2) at a spray height of 18 inches (43 centimeters (cm)) above the average plant canopy. Control or non-treated plants were sprayed in the same manner with the solvent blank or not treated. All herbicide application rates are given as grams acid equivalent per hectare (g ae / h) or grams active ingredient per hectare (g ai / h). The treated plants and control plants were returned to a greenhouse as described above and watered by subirrigation to prevent removal of the test compound. After 20-22 days, the condition of the test plants was compared with that of the control plants by visual assessment and evaluated based on a scoring scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete plant death. Visual assessments of plant injury were made based on growth reduction, discoloration, leaf deformity and necrosis. The value “NT” indicate that this was not tested for FIGs.1-18B, Tables 5A-22B. As can be seen from the data contained in FIGs. 1-18B, Tables 5A-22B, (i) the substituted 5-membered rings and mixtures thereof and (ii) additional substituted 5-membered rings with various mixing partners have herbicidal activity and help to solve the aforementioned need for new herbicides and methods to control the growth of undesirable vegetation in various locations. COMPOSITIONS Disclosed herein include compositions comprising compounds according to Formula I be mixed with or applied in combination with another compound, such as another pesticide, additive, or combination thereof. For example, disclosed compositions may comprise (a) a compound according to Formula I and (b) another herbicide. Yet another example of disclosed compositions may comprise (a) a compound according to Formula I, (b) another herbicide, and (c) another safener. Also, disclosed in include compositions that can comprise other substituted 5- membered rings selected from the following compounds (PYR-1 through PYR-21 and including all stereoisomers thereof) below and mixed with or applied in combination with another compound, such as another pesticide, additive, or combination thereof. Additional substituted 5-membered rings include the following compounds: TABLE 4: ADDITIONAL SUBSTITUTED 5-MEMBERED RINGS (JAS)

[0010] For example, disclosed compositions may comprise (a) one of the aforementioned additional substituted 5-membered ring herbicides and (b) another herbicide in ratios surprisingly discovered. Yet another example of disclosed compositions may comprise (a) one of the aforementioned additional substituted 5-membered ring herbicides, (b) another herbicide, and (c) another safener in ratios also discovered. PYR-3: Methyl (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetate PYR-3 PYR-3 was prepared as follows: In a 250 mL round-bottomed flask charged with magnetic stir bar was added methyl (S)-2-(5-oxopyrrolidin-2-yl)acetate (3.1 g, 20 mmol) in THF (100 mL) under N2. Lithium bis(trimethylsilyl)amide solution (1M in THF, 20 mL, 20 mmol) added at 0 °C and kept at this temperature for 15 min. 1-(Bromomethyl)-2,3- difluorobenzene (6.2 g, 30 mmol) was added and then the reaction was stirred at 55 °C for 18 hr. The crude reaction mixture was diluted with MeOH (5 mL) and concentrated onto celite, then purified by silica gel chromatography. The reaction product was a yellow oil (93% yield, 87% purity). The following data was generated to confirm the identity of PYR-3: ESIMS^m / z^284.2 [(M+H)+];1H NMR (400 MHz, Chloroform-d) δ 7.14 – 7.00 (m, 3H), 4.87 (dd, J = 15.5, 1.8 Hz, 1H), 4.24 (d, J = 15.5 Hz, 1H), 3.88 (tt, J = 8.7, 4.4 Hz, 1H), 3.66 (s, 3H), 2.71 (dd, J = 15.6, 4.1 Hz, 1H), 2.57 – 2.34 (m, 3H), 2.27 (ddt, J = 13.1, 9.7, 7.5 Hz, 1H), 1.83 (ddt, J = 13.0, 9.9, 5.1 Hz, 1H).;19F NMR (376 MHz, Chloroform-d) δ -137.87 (d, J = 21.7 Hz), -144.17 (d, J = 21.3 Hz). PYR-4: (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid PYR-4 PYR-4 was prepared as follows: In a 100 mL round-bottomed flask charged with magnetic stir bar was added methyl (S)-2-(1-(2,3-difluorobenzyl)-5-oxopyrrolidin-2- yl)acetate (5.3 g, 19 mmol) and lithium hydroxide (2.2 g, 93 mmol) in a THF (27 mL) / water (9.3 mL) solvent mixture. The reaction was stirred at 20 °C for 18 hr. The crude reaction was acidified with 3M HCl (32 mL), and then the mixture was extracted with ethyl acetate (40 mL) for 3 times. The combined organic layer was dried over Na2SO4, filtered, and concentrated. Purified by silica column chromatography yield PYR-4 as a white solid (83% yield, 99% purity). The following data was generated to confirm the identity of PYR-4: ESIMS^m / z^270.1 [(M+H)+];1H NMR (400 MHz, DMSO-d6) δ 12.38 (br. s, 1H), 7.35 (dtd, J = 9.9, 8.0, 1.7 Hz, 1H), 7.18 (tdd, J = 8.2, 5.0, 1.5 Hz, 1H), 7.12 – 7.03 (m, 1H), 4.72 (d, J = 15.9 Hz, 1H), 4.23 (d, J = 15.9 Hz, 1H), 3.76 (tt, J = 8.4, 4.2 Hz, 1H), 2.68 (dd, J = 15.9, 4.1 Hz, 1H), 2.47 – 2.32 (m, 2H), 2.31 – 2.11 (m, 2H), 1.80 – 1.66 (m, 1H).;19F NMR (376 MHz, DMSO-d6) δ -139.32 (d, J = 22.1 Hz), -144.23 (d, J = 22.0 Hz). PYR-5: Methyl (S)-2-(1-(2,3,5-trifluorobenzyl)-5-oxopyrrolidin-2-yl)acetate PYR-5 PYR-5 was prepared as follows: In a 250 mL round-bottomed flask charged with magnetic stir bar was added methyl (S)-2-(5-oxopyrrolidin-2-yl)acetate (1.6 g, 10 mmol) in THF (50 mL) under N2. lithium bis(trimethylsilyl)amide (10 mL, 10 mmol) added at 0 °C and kept at this temperature for 15 min.1-(bromomethyl)-2,3,5-trifluorobenzene (3.4 g, 15 mmol) was added and then the reaction was stirred at 55 °C for 16 hr. The crude reaction mixture was diluted with MeOH (5 mL) and concentrated onto celite, then purified by silica gel chromatography. The reaction product was a yellow oil (80% yield, 95% purity).The following data was generated to confirm the identity of PYR-5: ESIMSm / z302.2 [(M+H)+];1H NMR (500 MHz, Chloroform-d) δ 6.90 – 6.76 (m, 2H), 4.79 (dd, J = 15.8, 1.8 Hz, 1H), 4.25 (d, J = 15.8 Hz, 1H), 3.90 (tt, J = 8.5, 4.5 Hz, 1H), 3.67 (s, 3H), 2.69 (dd, J = 15.6, 4.3 Hz, 1H), 2.59 – 2.47 (m, 1H), 2.45 – 2.36 (m, 2H), 2.30 (dddd, J = 13.1, 9.8, 7.8, 7.1 Hz, 1H), 1.91 – 1.78 (m, 1H).;19F NMR (471 MHz, Chloroform-d) δ -114.16 – -114.31 (m), -132.87 – -132.96 (m), -148.79 (dd, J = 20.9, 15.2 Hz). PYR-6: (S)-2-(1-(2,3,5-trifluorobenzyl)-5-oxopyrrolidin-2-yl)acetic acid PYR-6 was prepared as follows: In a 500 mL round-bottomed flask charged with magnetic stir bar was added methyl (S)-2-(5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2- yl)acetate (13 g, 43 mmol) and sodium hydroxide (23 mL, 47 mmol) solution in THF (200 mL). The reaction was stirred at 20 °C for 20 hr. The crude reaction was concentrated to remove most THF, then the obtained oil was dilute with ethyl acetate(150 mL) and acidified with 3M HCl (16 mL). The two phases were separated, and the aqueous layer was thrice extracted with ethyl acetate (50 mL). The combined organics were washed with brine (50 mL), dried over Na2SO4, filtered, and the concentrated to afford the product as an off-white solid (96% yield, 97% purity). The following data was generated to confirm the identity of PYR-6: ESIMSm / z288.1 [(M+H)+];1H NMR (400 MHz, DMSO-d6) δ 12.38 (s, 1H), 7.45 (dddd, J = 11.2, 9.0, 6.1, 3.1 Hz, 1H), 6.96 (dp, J = 8.1, 2.4 Hz, 1H), 4.67 (d, J = 16.1 Hz, 1H), 4.26 (d, J = 16.1 Hz, 1H), 3.80 (tt, J = 8.5, 4.4 Hz, 1H), 2.68 (dd, J = 16.0, 4.3 Hz, 1H), 2.40 (ddd, J = 16.1, 10.4, 7.5 Hz, 2H), 2.32 – 2.14 (m, 2H), 1.81 – 1.67 (m, 1H).;19F NMR (376 MHz, DMSO- d6) δ -114.83 – -114.90 (m), -134.47 (dd, J = 21.9, 3.2 Hz), -148.16 (dd, J = 21.8, 15.8 Hz). SAFENED COMPOSITIONS A safened composition comprising compounds according to Formula I may be mixed with or applied in combination with (b) a safener, such as an azole carboxylate safener or an agriculturally acceptable salt or ester thereof. Also, safened compositions comprising the aforementioned PYR-1 through PYR- 16 (AND ALL STEREOISOMERS THEREOF) compounds may be mixed in combination with (b) a safener. In some aspects, (a) and (b) are used in an amount sufficient to induce an enhanced herbicidal effect (e.g., increased damage or injury to undesirable vegetation) while still showing good crop compatibility (e.g., no increased damage to crops or minimal increased damage or injury to crops) when compared to the individual application of the herbicidal compounds (a) or (b). In some aspects, the damage or injury to undesirable vegetation caused by the safened compositions and methods disclosed herein is evaluated using a scale from 0% to 100%, when compared with the untreated control vegetation, wherein 0% indicates no damage to the undesirable vegetation and 100% indicates complete destruction of the undesirable vegetation. Similarly, in some aspects, the damage or injury to the crop caused by the safened compositions and methods disclosed herein is evaluated using a scale from 0% to 100%, when compared with control crops treated with only the herbicide or the safener, wherein 0% indicates no damage to the crop and 100% indicates complete destruction of the crop. In some aspects, the joint action of (a) the compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof) and (b) the azole carboxylate safener or an agriculturally acceptable salt or ester thereof results in enhanced herbicidal effect against undesirable vegetation, even at application rates below those typically used for the herbicide to have a herbicidal effect on its own. In some aspects, the compositions and methods disclosed herein can, based on the individual components, be used at lower application rates to achieve a herbicidal effect comparable to the effect produced by the individual components at normal application rates. In some aspects, the joint action of (a) the compounds according to Formula I and (b) the azole carboxylate safener or an agriculturally acceptable salt or ester thereof results in protective effect for desired crops against damage to the crops that might be caused by the herbicide alone. In some aspects, the weight ratio of (a) the compounds according to Formula I (in g ae / ha) or (a) the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), to (b) the azole carboxylate safener or an agriculturally acceptable salt or ester thereof (in g ai / ha) can be 1:5 or more, such as 1:4.75 or more, 1:4.5 or more, 1:4.25 or more, 1:4 or more, 1:3.75 or more, 1:3.5 or more, 1:3.25 or more, 1:3 or more, 1:2.75 or more, 1:2.5 or more, 1:2.25 or more, 1:2 or more, 1:1.9 or more, 1:1.8 or more, 1:1.7 or more, 1:1.6 or more, 1:1.5 or more, 1:1.4 or more, 1:1.3 or more, 1:1.2 or more, 1:1.1 or more, 1:1 or more, 1.1:1 or more, 1.2:1 or more, 1.3:1 or more, 1.4:1 or more, 1.5:1 or more, 1.6:1 or more, 1.7:1 or more, 1.8:1 or more, 1.9:1 or more, 2:1 or more, 2.25:1 or more, 2.5:1 or more, 2.75:1 or more, 3:1 or more, 3.25:1 or more, 3.5:1 or more, 3.75:1 or more, 4:1 or more, 4.25:1 or more, 4.5:1 or more, 4.75:1 or more, or 5:1 or more; the weight ratio of (a) to (b) can be 5:1 or less, such as 4.75:1 or less, 4.5:1 or less, 4.25:1 or less, 4:1 or less, 3.75:1 or less, 3.5:1 or less, 3.25:1 or less, 3:1 or less, 2.75:1 or less, 2.5:1 or less, 2.25:1 or less, 2:1 or less, 1.9:1 or less, 1.8:1 or less, 1.7:1 or less, 1.6:1 or less, 1.5:1 or less, 1.4:1 or less, 1.3:1 or less, 1.2:1 or less, 1.1:1 or less, 1:1 or less, 1:1.1 or less, 1:1.2 or less, 1:1.3 or less, 1:1.4 or less, 1:1.5 or less, 1:1.6 or less, 1:1.7 or less, 1:1.8 or less, 1:1.9 or less, 1:2 or less, 1:2.25 or less, 1:2.5 or less, 1:2.75 or less, 1:3 or less, 1:3.25 or less, 1:3.5 or less, 1:3.75 or less, 1:4 or less, 1:4.25 or less, 1:4.5 or less, or 1:4.75 or less; or the weight ratio of (a) to (b) can range from any of the minimum ratios to any of the maximum ratios provided above, such as from 1:5 to 5:1, from 1:2 to 5:1, from 1:1 to 3:1, from 1:3 to 4:1, or from 1:1.5 to 3.5:1. In some aspects, (a) and (b), independently, can be employed in a purity of from 90% to 100% (e.g., from 95% to 100%) according to nuclear magnetic resonance (NMR) spectroscopy. AZOLE CARBOXYLATE SAFENERS In addition to the compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), the compositions and methods of the present disclosure can include an azole carboxylate safener or an agriculturally acceptable salt or ester thereof. Herbicide safeners are molecules used in combination with herbicides to make them “safer” – that is, to reduce the herbicidal effect of the herbicide on crop plants and to improve selectivity between crops and the undesirable vegetation being targeted by the herbicide. Herbicide safeners can be used to pre-treat crop seeds prior to planting. Herbicide safeners may also be sprayed on plants as a mixture with the herbicide, or separately and sequentially with the herbicide. Azoles are a class of five-membered nitrogen heterocyclic ring compounds containing at least one additional heteroatom (e.g., nitrogen, sulfur, or oxygen) within the heterocyclic ring. Examples of azoles include, for example, pyrazoles, imidazoles, thiazoles, oxazoles, isoxazoles and triazoles. Azole carboxylate safeners are a class of safeners based on carboxylate-substituted azole moieties. Examples of azole carboxylate safeners include pyrazole carboxylate safeners, imidazole carboxylate safeners, thiazole carboxylate safeners, oxazole carboxylate safeners, isoxazole carboxylate safeners, and triazole carboxylate safeners. In some aspects, the composition can include an azole carboxylate safener selected from the group consisting of fenchlorazole, flurazole, furilazole, isoxadifen, mefenpyr, agriculturally acceptable salts or esters thereof, or combinations thereof. In some aspects, the azole carboxylate safener can include fenchlorazole-ethyl, isoxadifen-ethyl, mefenpyr-diethyl, or combinations thereof. In some aspects, the azole carboxylate safener can comprise fenchlorazole, shown below, or an agriculturally acceptable salt or ester thereof. Fenchlorazole’s safening activity is described in The Pesticide Manual, Eighteenth Edition, 2016. In some aspects, the fenchlorazole is provided as an agriculturally acceptable salt or ester. An exemplary agriculturally acceptable ester of fenchlorazole is fenchlorazole–ethyl, shown below. In some aspects, the azole carboxylate safener can comprise flurazole, shown below, or an agriculturally acceptable salt or ester thereof. Flurazole’s safening activity is described in The Pesticide Manual, Eighteenth Edition, 2016. In some aspects, the azole carboxylate safener can comprise furilazole, shown below, or an agriculturally acceptable salt or ester thereof. Furilazole’s safening activity is described in The Pesticide Manual, Eighteenth Edition, 2016. In some aspects, the azole carboxylate safener can comprise isoxadifen, shown below, or an agriculturally acceptable salt or ester thereof. Isoxadifen’s safening activity is described in The Pesticide Manual, Eighteenth Edition, 2016. In some aspects, the isoxadifen is provided as an agriculturally acceptable salt or ester. An exemplary agriculturally acceptable ester of isoxadifen is isoxadifen-ethyl, shown below. In some aspects, the azole carboxylate safener can comprise mefenpyr, shown below, or an agriculturally acceptable salt or ester thereof. Mefenpyr’s safening activity is described in The Pesticide Manual, Eighteenth Edition, 2016.

[0011] In some aspects, the mefenpyr is provided as an agriculturally acceptable salt or ester. An exemplary agriculturally acceptable ester of mefenpyr is mefenpyr-diethyl, shown below. Azole carboxylate safeners include, for example, isoxadifen and agriculturally acceptable salts and esters thereof. Isoxadifen has the following chemical structure. This form of isoxadifen may also be referred to as "isoxadifen-acid." In some aspects, the safener may comprise isoxadifen-acid, an agriculturally acceptable salt of isoxadifen, an agriculturally acceptable ester of isoxadifen, or mixtures thereof. An exemplary agriculturally acceptable ester of isoxadifen is isoxadifen-ethyl, shown below. In some aspects, the azole carboxylate safener can be provided as an agriculturally acceptable ester. Suitable esters include, but are not limited to, methyl, ethyl, isopropyl, butyl, hexyl, heptyl, isoheptyl, mexyl, isooctyl, 2-ethylhexyl and butoxyethyl esters, and aryl esters such as benzyl. Exemplary agriculturally acceptable esters of the azole carboxylate safeners described herein include methyl, ethyl, and diethyl esters. In some aspects, the azole carboxylate safener can comprise an agriculturally acceptable salt of the azole carboxylate safener. Agriculturally acceptable salts of the azole carboxylate safener include, for example sodium, potassium, ammonium, monoethanolammonium, diethanolammonium, triethanolammonium, monoisopropanolammonium, diisopropanolammonium, triisopropanolammonium, choline, N,N-dimethylethanolammonium, diethylammonium, dimethylammonium, trimethylammonium, triethylammonium, and isopropylammonium salts of the azole carboxylate safener. An azole carboxylate safener, when applied in combination with herbicides, can be used to reduce phytotoxicity to crops such as wheat, barley, triticale, rye, teff, oats, maize, sorghum, millet, rice, millet, canola / oilseed rape, flax, soy, sunflower, sugar beet, cotton, sugarcane, and pasture grasses. The azole carboxylate safener or an agriculturally acceptable salt or ester thereof can be used in an amount sufficient to induce a safening effect. In some aspects, the azole carboxylate safener is selected from the group consisting of fenchlorazole, fenclorim, flurazole, furilazole, isoxadifen, mefenpyr, an agriculturally acceptable salt or ester thereof, or combinations thereof, and is applied to vegetation or an area adjacent the vegetation or applied to soil or water in an amount of 1 g active ingredient per hectare (ai / ha) or greater, such as 2 g ai / ha or greater, 3 g ai / ha or greater, 4 g ai / ha or greater, 5 g ai / ha or greater, 6 g ai / ha or greater, 7 g ai / ha or greater, 8 g ai / ha or greater, 9 g ai / ha or greater, 10 g ai / ha or greater, 11 g ai / ha or greater, 12 g ai / ha or greater, 13 g ai / ha or greater, 14 g ai / ha or greater, 15 g ai / ha or greater, 16 g ai / ha or greater, 17 g ai / ha or greater, 18 g ai / ha or greater, 19 g ai / ha or greater, 20 g ai / ha or greater, 22 g ai / ha or greater, 24 g ai / ha or greater, 25 g ai / ha or greater, 26 g ai / ha or greater, 28 g ai / ha or greater, 30 g ai / ha or greater, 32 g ai / ha or greater, 34 g ai / ha or greater, 35 g ai / ha or greater, 36 g ai / ha or greater, 38 g ai / ha or greater, 40 g ai / ha or greater, 42.5 g ai / ha or greater, 45 g ai / ha or greater, 47.5 g ai / ha or greater, 50 g ai / ha or greater, 52.5 g ai / ha or greater,55 g ai / ha or greater, 57.5 g ai / ha or greater, 60 g ai / ha or greater, 65 g ai / ha or greater, 70 g ai / ha or greater, 75 g ai / ha or greater, 80 g ai / ha or greater, 85 g ai / ha or greater, 90 g ai / ha or greater, 95 g ai / ha or greater, 100 g ai / ha or greater, 110 g ai / ha or greater, 120 g ai / ha or greater, 130 g ai / ha or greater, 140 g ai / ha or greater, 150 g ai / ha or greater, 160 g ai / ha or greater, 170 g ai / ha or greater, 180 g ai / ha or greater, 190 g ai / ha or greater, 200 g ai / ha or greater, 210 g ai / ha or greater, 220 g ai / ha or greater, 230 g ai / ha or greater, 240 g ai / ha or greater, 250 g ai / ha or greater, 260 g ai / ha or greater, 270 g ai / ha or greater, 280 g ai / ha or greater, or 290 g ai / ha or greater; in an amount of 300 g ai / ha or less, such as 290 g ai / ha or less, 280 g ai / ha or less, 270 g ai / ha or less, 260 g a / ha or less, 250 g ai / ha or less, 240 g ai / ha or less, 230 g ai / ha or less, 220 g ai / ha or less, 210 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 95 g ai / ha or less, 90 g ai / ha or less, 85 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 65 g ai / ha or less, 60 g ai / ha or less, 57.5 g ai / ha or less, 55 g ai / ha or less, 52.5 g ai / ha or less, 50 g ai / ha or less, 47.5 g ai / ha or less, 45 g ai / ha or less, 42.5 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 25 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount within any range defined between any pair of the preceding values, such as from 1 g ai / ha to 300 g ai / ha, from 5 g ai / ha to 150 g ai / ha, from 10 g ai / ha to 200 g ai / ha, from 20 g ai / ha to 75 g ai / ha, or from 40 g ai / ha to 100 g ai / ha. FORMULATIONS The present disclosure also includes formulations of the compositions and methods disclosed herein. Additives The compositions and methods disclosed herein can also be mixed with or applied with an additive. In some aspects, the additive is added sequentially. In some aspects, the additive is added simultaneously. In some aspects, the additive is premixed with the compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof). In some aspects, the additive is premixed with the azole carboxylate safener or agriculturally acceptable salt or ester thereof. OTHER PESTICIDES Some aspects of the disclosed safened compositions disclosed include adding one or more additional pesticide active ingredients to the safened compositions. These pesticide active ingredients may include one or more of an herbicide, an insecticide, a fungicide, a nematocide, a miticide, a arthropodicide, a bactericide, a plant growth regulator, or combinations thereof that are compatible with the compositions of the present disclosure. In some aspects, the additive is an additional herbicide. For example, the compositions described herein can be applied in conjunction with one or more additional herbicides to control undesirable vegetation. The composition can be formulated with the one or more additional herbicides, tank mixed with the one or more additional herbicides, or applied sequentially with the one or more additional herbicides, such as the exemplary herbicides described below. ALS Inhibitors In addition to the compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), the compositions can include an acetolactate synthase (ALS) inhibitor. ALS inhibitors disrupt the production of amino acids in the plant, which eventually leads to inhibition of DNA synthesis. Examples of ALS inhibitors include sulfonylureas, imidazolinones, triazolopyrimidine sulfonamides, pyrimidinyl oxybenzoates and sulfonylaminocarbonyl triazolinones. In some aspects, the ALS inhibitor can contain a triazolopyrimidine sulfonamide herbicide. In some aspects, the ALS inhibitor can contain an imidazolinone herbicide. In some aspects, the ALS inhibitor can contain a pyrimidinyl oxybenzoate herbicide. In some aspects, the ALS inhibitor can contain a sulfonylaminocarbonyl triazolinone herbicide. In some aspects, the ALS inhibitor can contain a sulfonylurea herbicide. In some aspects, the composition can include an ALS inhibitor selected from the group of imidazolinones, triazolopyrimidine sulfonamides, pyrimidinyl oxybenzoates, sulfonylaminocarbonyl triazolinones, sulfonylureas, and combinations thereof. In some cases, the composition can include amidosulfuron, azimsulfuron, bispyribac, bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cloransulam, cyclosulfamuron, diclosulam, ethametsulfuron, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone, flucetosulfuron, flumetsulam, flupyrsulfuron, foramsulfuron, halosulfuron, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, iodosulfuron, iofensulfuron, mesosulfuron, metazosulfuron, metosulam, metsulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, penoxsulam, primisulfuron, propoxycarbazone, propyrisulfuron, prosulfuron, pyrazosulfuron, pyribenzoxim, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, pyroxsulam, rimsulfuron, sulfometuron, sulfosulfuron, thiencarbazone, thifensulfuron, triasulfuron, tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, agriculturally acceptable salts and esters thereof, and combinations thereof. The ALS inhibitor or agriculturally acceptable salt or ester thereof can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, the ALS inhibitor or agriculturally acceptable salt or ester thereof is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 0.25 grams active ingredient per hectare (g ai / ha) or more, such as 0.3 g ai / ha or more, 0.4 g ai / ha or more, 0.5 g ai / ha or more, 0.6 g ai / ha or more, 0.7 g ai / ha or more, 0.8 g ai / ha or more, 0.9 g ai / ha or more, 1 g ai / ha or more, 1.5 g ai / ha or more, 2 g ai / ha or more, 2.5 g ai / ha or more, 3 g ai / ha or more, 3.5 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 55 g ai / ha or more, 60 g ai / ha or more, 65 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 85 g ai / ha or more, 90 g ai / ha or more, 95 g ai / ha or more, 100 g ai / ha or more, 110 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, 170 g ai / ha or more, 180 g ai / ha or more, 190 g ai / ha or more, 200 g ai / ha or more, 220 g ai / ha or more, 240 g ai / ha or more, 250 g ai / ha or more, 260 g ai / ha or more, 280 g ai / ha or more, 300 g ai / ha or more, 320 g ai / ha or more, 340 g ai / ha or more, 350 g ai / ha or more, 360 g ai / ha or more, 380 g ai / ha or more, 400 g ai / ha or more, 420 g ai / ha or more, 440 g ai / ha or more, 460 g ai / ha or more, 480 g ai / ha or more, 500 g ai / ha or more, 520 g ai / ha or more, 540 g ai / ha or more, 560 g ai / ha or more, 580 g ai / ha or more, 600 g ai / ha or more, 625 g ai / ha or more, 650 g ai / ha or more, 675 g ai / ha or more, 700 g ai / ha or more, 725 g ai / ha or more, 750 g ai / ha or more, 775 g ai / ha or more, 800 g ai / ha or more, 825 g ai / ha or more, 850 g ai / ha or more, 875 g ai / ha or more, 900 g ai / ha or more, 925 g ai / ha or more, 950 g ai / ha or more, 975 g ai / ha or more, 1000 g ai / ha or more, 1050 g ai / ha or more, 1100 g ai / ha or more, 1150 g ai / ha or more, 1200 g ai / ha or more, 1250 g ai / ha or more, 1300 g ai / ha or more, 1350 g ai / ha or more, 1400 g ai / ha or more, 1450 g ai / ha or more, 1500 g ai / ha or more, 1550 g ai / ha or more, 1600 g ai / ha or more, 1650 g ai / ha or more, 1675 g ai / ha or more, 1680 g ai / ha or more, or 1690 g ai / ha or more; in an amount of 1700 g ai / ha or less, such as 1690 g ai / ha or less, 1680 g ai / ha or less, 1675 g ai / ha or less, 1650 g ai / ha or less, 1600 g ai / ha or less, 1550 g ai / ha or less, 1500 g ai / ha or less, 1450 g ai / ha or less, 1400 g ai / ha or less, 1350 g ai / ha or less, 1300 g ai / ha or less, 1250 g ai / ha or less, 1200 g ai / ha or less, 1150 g ai / ha or less, 1100 g ai / ha or less, 1050 g ai / ha or less, 1000 g ai / ha or less, 975 g ai / ha or less, 950 g ai / ha or less, 925 g ai / ha or less, 900 g ai / ha or less, 875 g ai / ha or less, 850 g ai / ha or less, 825 g ai / ha or less, 800 g ai / ha or less, 775 g ai / ha or less, 750 g ai / ha or less, 725 g ai / ha or less, 700 g ai / ha or less, 675 g ai / ha or less, 650 g ai / ha or less, 625 g ai / ha or less, 600 g ai / ha or less, 580 g ai / ha or less, 560 g ai / ha or less, 540 g ai / ha or less, 520 g ai / ha or less, 500 g ai / ha or less, 480 g ai / ha or less, 460 g ai / ha or less, 440 g ai / ha or less, 420 g ai / ha or less, 400 g ai / ha or less, 380 g ai / ha or less, 360 g ai / ha or less, 350 g ai / ha or less, 340 g ai / ha or less, 320 g ai / ha or less, 300 g ai / ha or less, 280 g ai / ha or less, 260 g ai / ha or less, 250 g ai / ha or less, 240 g ai / ha or less, 220 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 95 g ai / ha or less, 90 g ai / ha or less, 85 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 65 g ai / ha or less, 60 g ai / ha or less, 55 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.5 g ai / ha or less, 4 g ai / ha or less, 3.5 g ai / ha or less, 3 g ai / ha or less, 2.5 g ai / ha or less, 2 g ai / ha or less, 1.5 g ai / ha or less, 1 g ai / ha or less, 0.9 g ai / ha or less, 0.8 g ai / ha or less, 0.7 g ai / ha or less, 0.6 g ai / ha or less, 0.5 g ai / ha or less, 0.4 g ai / ha or less, or 0.3 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 0.25–1700 g ai / ha, 0.25–1250 g ai / ha, 0.5–150 g ai / ha, 2–90 g ai / ha, 2.5–200 g ai / ha, 3–900 g ai / ha, 5–260 g ai / ha, 5–750 g ai / ha, 5–1000 g ai / ha, 6–280 g ai / ha, 7–100 g ai / ha, 10–560 g ai / ha, 10–1600 g ai / ha, 20–500 g ai / ha, 25–140 g ai / ha, 30–480 g ai / ha, 40–400 g ai / ha, 50–320 g ai / ha, 60–300 g ai / ha, 70–1250 g ai / ha, 100–140 g ai / ha, 140–520 g ai / ha, or 250–1700 g ai / ha. Triazolopyrimidine Sulfonamide Herbicides In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) florasulam, cloransulam, diclosulam, flumetsulam, metosulam, penoxsulam, or pyroxsulam, or agriculturally acceptable salts or esters thereof. Florasulam Compositions and methods of the present disclosure can include florasulam or an agriculturally acceptable salt or ester thereof. Florasulam, shown below, is a triazolopyrimidine sulfonamide that provides broad-spectrum control of many broad-leaved weeds in cereals and maize. Florasulam, as well as methods of preparing florasulam, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Sixteenth Edition, 2012. Florasulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, florasulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 0.25 g ai / ha or more, such as 0.3 g ai / ha or more, 0.4 g ai / ha or more, 0.5 g ai / ha or more, 0.6 g ai / ha or more, 0.7 g ai / ha or more, 0.8 g ai / ha or more, 0.9 g ai / ha or more, 1 g ai / ha or more, 1.1 g ai / ha or more, 1.25 g ai / ha or more, 1.5 g ai / ha or more, 1.75 g ai / ha or more, 2 g ai / ha or more, 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 5.25 g ai / ha or more, 5.5 g ai / ha or more, 5.75 g ai / ha or more, 6 g ai / ha or more, 6.25 g ai / ha or more, 6.5 g ai / ha or more, 6.75 g ai / ha or more, 7 g ai / ha or more, 7.25 g ai / ha or more, 7.5 g ai / ha or more, 8 g ai / ha or more, 8.5 g ai / ha or more, 9 g ai / ha or more, or 9.5 g ai / ha, or more; in an amount of 10 g ai / ha or less, such as 9.5 g ai / ha or less, 9 g ai / ha or less, 8.5 g ai / ha or less, 8 g ai / ha or less 7.5 g ai / ha or less, 7.25 g ai / ha or less, 7 g ai / ha or less, 6.75 g ai / ha or less, 6.5 g ai / ha or less, 6.25 g ai / ha or less, 6 g ai / ha or less, 5.75 g ai / ha or less, 5.5 g ai / ha or less, 5.25 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, 2.25 g ai / ha or less, 2 g ai / ha or less, 1.75 g ai / ha or less, 1.5 g ai / ha or less, 1.25 g ai / ha or less, 1 g ai / ha or less, 0.9 g ai / ha or less, 0.8 g ai / ha or less, 0.7 g ai / ha or less, 0.6 g ai / ha or less, 0.5 g ai / ha or less, 0.4 g ai / ha or less, or 0.3 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 0.25–10 g ai / ha, 0.25–7 g ai / ha, 0.4–6.5 g ai / ha, 0.5–6 g ai / ha, 0.6–9 g ai / ha, 0.7–8.5 g ai / ha, 0.8–4.5 g ai / ha, 1–4 g ai / ha, 1.1-7.5 g ai / ha, 1.5–5.75 g ai / ha, 2–7.25 g ai / ha, 2.25–10 g ai / ha, 3–8.5 g ai / ha, or 3.5–9.5 g ai / ha. Cloransulam Compositions and methods of the present disclosure can include cloransulam or an agriculturally acceptable salt or ester thereof. Cloransulam, as well as methods of preparing cloransulam, are known in the art. In some aspects, cloransulam can be provided as an agriculturally acceptable ester of cloransulam. Cloransulam-methyl, shown below, is a triazolopyrimidine sulfonamide that provides broad-spectrum control of many broadleaf weeds in soybeans and other broadleaf crops. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Cloransulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, cloransulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.18 g ai / ha or more, such as 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 51 g ai / ha or more, 52 g ai / ha or more, 53 g ai / ha or more, 54 g ai / ha or more, 55 g ai / ha or more, 56 g ai / ha or more, 57 g ai / ha or more, 58 g ai / ha or more, or 59 g ai / ha or more; in an amount of 61 g ai / ha or less, such as 60 g ai / ha or less, 59 g ai / ha or less, 58 g ai / ha or less, 57 g ai / ha or less, 56 g ai / ha or less, 55 g ai / ha or less, 54 g ai / ha or less, 53 g ai / ha or less, 52 g ai / ha or less, 51 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.5 g ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, or 2.25 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.18–61 g ai / ha, 2.5–60 g ai / ha, 2.75–44 g ai / ha, 3–59 g ai / ha, 3.25–60 g ai / ha, 3.5–40 g ai / ha, 3.75–18 g ai / ha, 3.75–50 g ai / ha, 4–60 g ai / ha, 4–52 g ai / ha, 4.25–30 g ai / ha, 4.25–55 g ai / ha, 4.5–51 g ai / ha, or 5–38 g ai / ha. Diclosulam Compositions and methods of the present disclosure can include diclosulam or an agriculturally acceptable salt or ester thereof. Diclosulam, shown below, is a triazolopyrimidine sulfonamide that provides broad-spectrum control of many broadleaf weeds in soybeans and peanuts. Diclosulam, as well as methods of preparing diclosulam, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Diclosulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, diclosulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.18 g ai / ha or more, such as 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 27 g ai / ha or more, 28 g ai / ha or more, 29 g ai / ha or more, 30 g ai / ha or more, 31g ai / ha or more, 31.5 g ai / ha or more, 32 g ai / ha or more, 32.5 g ai / ha or more, 33 g ai / ha or more, 33.5 g ai / ha or more, 34 g ai / ha or more, 34.5 g ai / ha or more, or 34.75 g ai / ha or more; in an amount of 35 g ai / ha or less, such as 34.5 g ai / ha or less, 34 g ai / ha or less, 33.5 g ai / ha or less, 33 g ai / ha or less, 32.5 g ai / ha or less, 32 g ai / ha or less, 31.5 g ai / ha or less, 31 g ai / ha or less, 30 g ai / ha or less, 29 g ai / ha or less, 28 g ai / ha or less, 27 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.5 g ai / ha or less, 4 g ai / ha or less, 3.5 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, 2.25 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.18–35 g ai / ha, 2.5–34 g ai / ha, 2.75–22 g ai / ha, 3–29 g ai / ha, 3.25–34 g ai / ha, 3.25–32 g ai / ha, 3.5–30 g ai / ha, 3.75–27 g ai / ha, 4–35 g ai / ha, 4–30 g ai / ha, 4.5–18 g ai / ha, 4.5–33.5 g ai / ha, 5–32 g ai / ha, or 6–33 g ai / ha. Flumetsulam Compositions and methods of the present disclosure can include flumetsulam or an agriculturally acceptable salt or ester thereof. Flumetsulam, shown below, is a triazolopyrimidine sulfonamide that provides control of broadleaf weeds and greens in soybeans, field peas, and maize. Flumetsulam, as well as methods of preparing flumetsulam, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Flumetsulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, flumetsulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.18 g ai / ha or more, such as 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.5 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 7 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 36 g ai / ha or more, 37 g ai / ha or more, 38 g ai / ha or more, 39 g ai / ha or more, 40 g ai / ha or more, 41 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, 70 g ai / ha or more, 72 g ai / ha or more, 74 g ai / ha or more, or 77 g ai / ha or more; in an amount of 78 g ai / ha or less, such as 77 g ai / ha or less, 75 g ai / ha or less, 74 g ai / ha or less, 72 g ai / ha or less, 70 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 41 g ai / ha or less, 40 g ai / ha or less, 39 g ai / ha or less, 38 g ai / ha or less, 37 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 7 g ai / ha or less, 5 g ai / ha or less, 4.5 g ai / ha or less, 4 g ai / ha or less, 3.5 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.18–78 g ai / ha, 2.5–75 g ai / ha, 2.75–54 g ai / ha, 3–46 g ai / ha, 3–78 g ai / ha, 3.5–39 g ai / ha, 3.5–72 g ai / ha, 4–60 g ai / ha, 4–75 g ai / ha, 4.5–25 g ai / ha, 4.5–66 g ai / ha, 5–58 g ai / ha, or 9–62 g ai / ha. Penoxsulam Compositions and methods of the present disclosure can include penoxsulam or an agriculturally acceptable salt or ester thereof. Penoxsulam, shown below, is a triazolopyrimidine sulfonamide that provides control of Echinochloa spp., as well as many broadleaf, sedge, and aquatic weeds in rice. Penoxsulam, as well as methods of preparing penoxsulam, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Penoxsulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, penoxsulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.5 g ai / ha or more, such as 2.75 g ai / ha or more, 3 g ai / ha or more, 3.5 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 41 g ai / ha or more, 42 g ai / ha or more, 43 g ai / ha or more, 44 g ai / ha or more, 45 g ai / ha or more, 46 g ai / ha or more, 47 g ai / ha or more, 48 g ai / ha or more, or 49 g ai / ha or more; in an amount of 50 g ai / ha or less, such as 49 g ai / ha or less, 48 g ai / ha or less, 47 g ai / ha or less, 46 g ai / ha or less, 45 g ai / ha or less, 44 g ai / ha or less, 43 g ai / ha or less, 42 g ai / ha or less, 41 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, 4 g ai / ha or less, 3.5 g ai / ha or less, 3 g ai / ha or less, or 2.75 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.5– 50 g ai / ha, 3–28 g ai / ha, 3.5–40 g ai / ha, 4–34 g ai / ha, 4.25–50 g ai / ha, 4.5–47 g ai / ha, 5–45 g ai / ha, 6–36 g ai / ha, 8–22 g ai / ha, or 10–49 g ai / ha. Pyroxsulam Compositions and methods of the present disclosure can include pyroxsulam or an agriculturally acceptable salt or ester thereof. Pyroxsulam, shown below, is a triazolopyrimidine sulfonamide that provides broad spectrum post-emergence annual grass and broadleaf weeds control in cereals. Pyroxsulam, as well as methods of preparing pyroxsulam, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Pyroxsulam can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, pyroxsulam is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1.9 g ai / ha or more, such as 2 g ai / ha or more, 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.5 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 9.5 g ai / ha or more, 10 g ai / ha or more, 10.5 g ai / ha or more, 11 g ai / ha or more, 11.5 g ai / ha or more, 12 g ai / ha or more, 12.5 g ai / ha or more, 13 g ai / ha or more, 13.5 g ai / ha or more, 14 g ai / ha or more, 14.5 g ai / ha or more, 15 g ai / ha or more, 15.25 g ai / ha or more, 15.5 g ai / ha or more, 15.75 g ai / ha or more, 16 g ai / ha or more, 16.25 g ai / ha or more, 16.5 g ai / ha or more, 16.75 g ai / ha or more, 17 g ai / ha or more, 17.25 g ai / ha or more, 17.5 g ai / ha or more, 17.75 g ai / ha or more, 18 g ai / ha or more, 18.25 g ai / ha or more, or 18.5 g ai / ha or more; in an amount of 18.75 g ai / ha or less, such as 18.5 g ai / ha or less, 18.25 g ai / ha or less, 18 g ai / ha or less, 17.75 g ai / ha or less, 17.5 g ai / ha or less, 17.25 g ai / ha or less, 17 g ai / ha or less, 16.75 g ai / ha or less, 16.5 g ai / ha or less, 16.25 g ai / ha or less, 16 g ai / ha or less, 15.75 g ai / ha or less, 15.5 g ai / ha or less, 15.25 g ai / ha or less, 15 g ai / ha or less, 14.5 g ai / ha or less, 14 g ai / ha or less, 13.5 g ai / ha or less, 13 g ai / ha or less, 12.5 g ai / ha or less, 12 g ai / ha or less, 11.5 g ai / ha or less, 11 g ai / ha or less, 10.5 g ai / ha or less, 10 g ai / ha or less, 9.5 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.5 g ai / ha or less, 4 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, or 2.25 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1.9–18.75 g ai / ha, 2.25–18 g ai / ha, 2.5–14.5 g ai / ha, 2.75–12.5 g ai / ha, 2.75–18.5 g ai / ha, 3–13 g ai / ha, 3.25–10.5 g ai / ha, 3.5–16 g ai / ha, 4–15.25 g ai / ha, 5–18 g ai / ha, 6–17.75 g ai / ha, 8–16 g ai / ha, 9–18 g ai / ha, or 10–14.5 g ai / ha. IMIDAZOLINONE HERBICIDES In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, or agriculturally acceptable salts or esters thereof, or combinations thereof.

[0012] Imazamethabenz Compositions and methods of the present disclosure can include imazamethabenz or an agriculturally acceptable salt or ester thereof. Imazamethabenz, shown below, is a mixture of isomers and an imidazolinone that provides post-emergence control of Avena species, Alopecurus myosuroides, Apera spica-venti and dicotyledonous weeds in wheat, barley, rye and sunflowers. Imazamethabenz, as well as methods of preparing imazamethabenz, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Imazamethabenz can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, imazamethabenz is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 50 g ai / ha or more, such as 55 g ai / ha or more, 60 g ai / ha or more, 65 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 95 g ai / ha or more, 100 g ai / ha or more, 110 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, 170 g ai / ha or more, 180 g ai / ha or more, 190 g ai / ha or more, 200 g ai / ha or more, 220 g ai / ha or more, 240 g ai / ha or more, 260 g ai / ha or more, 280 g ai / ha or more, 300 g ai / ha or more, 320 g ai / ha or more, 340 g ai / ha or more, 360 g ai / ha or more, 380 g ai / ha or more, 400 g ai / ha or more, 420 g ai / ha or more, 440 g ai / ha or more, 460 g ai / ha or more, 480 g ai / ha or more, 500 g ai / ha or more, 520 g ai / ha or more, 540 g ai / ha or more, 560 g ai / ha or more, 580 g ai / ha or more, 600 g ai / ha or more, 620 g ai / ha or more, 640 g ai / ha or more, 650 g ai / ha or more, 660 g ai / ha or more, 670 g ai / ha or more, 680 g ai / ha or more, or 690 g ai / ha or more; in an amount of 700 g ai / ha or less, such as 690 g ai / ha or less, 680 g ai / ha or less, 670 g ai / ha or less, 660 g ai / ha or less, 650 g ai / ha or less, 640 g ai / ha or less, 620 g ai / ha or less, 600 g ai / ha or less, 580 g ai / ha or less, 560 g ai / ha or less, 540 g ai / ha or less, 520 g ai / ha or less, 500 g ai / ha or less, 480 g ai / ha or less, 460 g ai / ha or less, 440 g ai / ha or less, 420 g ai / ha or less, 400 g ai / ha or less, 380 g ai / ha or less, 360 g ai / ha or less, 340 g ai / ha or less, 320 g ai / ha or less, 300 g ai / ha or less, 280 g ai / ha or less, 260 g ai / ha or less, 240 g ai / ha or less, 220 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 95 g ai / ha or less, 90 g ai / ha or less, 85 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 65 g ai / ha or less, 60 g ai / ha or less, or 55 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 50–700 g ai / ha, 55–400 g ai / ha, 60–650 g ai / ha, 75–520 g ai / ha, 80–400 g ai / ha, 85–500 g ai / ha, 90–220 g ai / ha, 100–700 g ai / ha, 100– 500 g ai / ha, 110–640 g ai / ha, 120–420 g ai / ha, 120–500 g ai / ha, 140–670 g ai / ha, or 150–580 g ai / ha. Imazamox Compositions and methods of the present disclosure can include imazamox or an agriculturally acceptable salt or ester thereof. Imazamox, shown below, is an imidazolinone that provides pre- and post-emergence control of broadleaf and grass weeds, e.g., in rice, maize, rape, alfalfa, peas and beans. Imazamox, as well as methods of preparing imazamox, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Imazamox can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, imazamox is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 5 g ai / ha or more, such as 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 21 g ai / ha or more, 22 g ai / ha or more, 23 g ai / ha or more, 24 g ai / ha or more, 25 g ai / ha or more, 26 g ai / ha or more, 27 g ai / ha or more, 28 g ai / ha or more, 29 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, or 58 g ai / ha or more; in an amount of 60 g ai / ha or less, such as 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 29 g ai / ha or less, 28 g ai / ha or less, 27 g ai / ha or less, 26 g ai / ha or less, 25 g ai / ha or less, 24 g ai / ha or less, 23 g ai / ha or less, 22 g ai / ha or less, 21 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, or 6 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 5–60 g ai / ha, 5–52 g ai / ha, 6–46 g ai / ha, 6–54 g ai / ha, 7–38 g ai / ha, 7–50 g ai / ha, 8–48 g ai / ha, 9–45 g ai / ha, 10–40 g ai / ha, 10–58 g ai / ha, 11–36 g ai / ha, 12–54 g ai / ha, 13–60 g ai / ha, or 15–48 g ai / ha. Imazapic Compositions and methods of the present disclosure can include imazapic or an agriculturally acceptable salt or ester thereof. Imazapic, shown below, is an imidazolinone that provides pre- and post-emergence control of a wide range of annual and perennial weeds in pasture, rangeland and non-cropland areas. Imazapic, as well as methods of preparing imazapic, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Imazapic can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, imazapic is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 17.5 g ai / ha or more, such as 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 110 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 155 g ai / ha or more, 160 g ai / ha or more, 165 g ai / ha or more, 170 g ai / ha or more, 175 g ai / ha or more, 180 g ai / ha or more, 185 g ai / ha or more, 190 g ai / ha or more, 195 g ai / ha or more, 200 g ai / ha or more, 205 g ai / ha or more, 210 g ai / ha or more, or 215 g ai / ha or more; in an amount of 220 g ai / ha or less, such as 215 g ai / ha or less, 210 g ai / ha or less, 205 g ai / ha or less, 200 g ai / ha or less, 195 g ai / ha or less, 190 g ai / ha or less, 185 g ai / ha or less, 180 g ai / ha or less, 175 g ai / ha or less, 170 g ai / ha or less, 165 g ai / ha or less, 160 g ai / ha or less, 155 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, or 18 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 17.5–220 g ai / ha, 17.5–210 g ai / ha, 18–200 g ai / ha, 19–120 g ai / ha, 20–210 g ai / ha, 20–170 g ai / ha, 22–190 g ai / ha, 24–175 g ai / ha, 26–210 g ai / ha, 26–160 g ai / ha, 30–190 g ai / ha, 30–140 g ai / ha, 35–220 g ai / ha, or 45–215 g ai / ha. Imazapyr Compositions and methods of the present disclosure can include imazapyr or an agriculturally acceptable salt or ester thereof. Imazapyr, shown below, is an imidazolinone that provides pre- and post-emergence control of annual and perennial grasses, broadleaf weeds, brush and trees. Imazapyr, as well as methods of preparing imazapyr, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Imazapyr can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, imazapyr is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 100 g ai / ha or more, such as 120 g ai / ha or more, 125 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, 170 g ai / ha or more, 180 g ai / ha or more, 190 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 425 g ai / ha or more, 450 g ai / ha or more, 475 g ai / ha or more, 500 g ai / ha or more, 600 g ai / ha or more, 700 g ai / ha or more, 800 g ai / ha or more, 900 g ai / ha or more, 1000 g ai / ha or more, 1050 g ai / ha or more, 1100 g ai / ha or more, 1150 g ai / ha or more, 1200 g ai / ha or more, 1250 g ai / ha or more, 1300 g ai / ha or more, 1350 g ai / ha or more, 1400 g ai / ha or more, 1450 g ai / ha or more, 1500 g ai / ha or more, 1550 g ai / ha or more, 1600 g ai / ha or more, 1620 g ai / ha or more, 1640 g ai / ha or more, 1660 g ai / ha or more, or 1680 g ai / ha or more; in an amount of 1700 g ai / ha or less (e.g., 1680 g ai / ha or less, 1660 g ai / ha or less, 1640 g ai / ha or less, 1620 g ai / ha or less, 1600 g ai / ha or less, 1550 g ai / ha or less, 1500 g ai / ha or less, 1450 g ai / ha or less, 1400 g ai / ha or less, 1350 g ai / ha or less, 1300 g ai / ha or less, 1250 g ai / ha or less, 1200 g ai / ha or less, 1150 g ai / ha or less, 1100 g ai / ha or less, 1050 g ai / ha or less, 1000 g ai / ha or less, 900 g ai / ha or less, 800 g ai / ha or less, 700 g ai / ha or less, 600 g ai / ha or less, 500 g ai / ha or less, 475 g ai / ha or less, 450 g ai / ha or less, 425 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 125 g ai / ha or less, 120 g ai / ha or less, or 110 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 100–1700 g ai / ha, 125–850 g ai / ha, 130–700 g ai / ha, 150–1000 g ai / ha, 160–475 g ai / ha, 170–1660 g ai / ha, 180–1500 g ai / ha, 190– 1050 g ai / ha, 200–700 g ai / ha, 250–1500 g ai / ha, 325–1200 g ai / ha, 450–1500 g ai / ha, 500– 900 g ai / ha, or 110–1000 g ai / ha. Imazethapyr Compositions and methods of the present disclosure can include imazethapyr or an agriculturally acceptable salt or ester thereof. Imazethapyr, shown below, is an imidazolinone that controls many major annual and perennial grass and broadleaf weeds in most major crops. Imazethapyr, as well as methods of preparing imazethapyr, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Imazethapyr can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, imazethapyr is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 8.75 g ai / ha or more, such as 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, 170 g ai / ha or more, 180 g ai / ha or more, 190 g ai / ha or more, 200 g ai / ha or more, 210 g ai / ha or more, 220 g ai / ha or more, 230 g ai / ha or more, 240 g ai / ha or more, 250 g ai / ha or more, 260 g ai / ha or more, 270 g ai / ha or more, 272 g ai / ha or more, 274 g ai / ha or more, 276 g ai / ha or more, or 278 g ai / ha or more; in an amount of 280 g ai / ha or less, such as 278 g ai / ha or less, 276 g ai / ha or less, 274 g ai / ha or less, 272 g ai / ha or less, 270 g ai / ha or less, 260 g ai / ha or less, 250 g ai / ha or less, 240 g ai / ha or less, 230 g ai / ha or less, 220 g ai / ha or less, 210 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, or 9 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 8.75–280 g ai / ha, 8.75–170 g ai / ha, 9–220 g ai / ha, 10–260 g ai / ha, 10–150 g ai / ha, 11-220 g ai / ha, 12–200 g ai / ha, 13–274 g ai / ha, 15–230 g ai / ha, 16–160 g ai / ha, 18–280 g ai / ha, 20–210 g ai / ha, 20– 190 g ai / ha, or 25–272 g ai / ha. PYRIMIDINYL OXYBENZOATE HERBICIDES In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) bispyribac, pyribenzoxim, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, or agriculturally acceptable salts or esters thereof, or combinations thereof. Bispyribac Compositions and methods of the present disclosure can include bispyribac or an agriculturally acceptable salt or ester thereof. Bispyribac-sodium, shown below, is a pyrimidinyl oxybenzoate that provides control of grasses, sedges and broadleaf weeds, e.g., in direct-seeded and water-seeded rice and in turf. Bispyribac-sodium, as well as methods of preparing bispyribac-sodium, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Bispyribac can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, bispyribac is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 5 g ai / ha or more, such as 7.5 g ai / ha or more, 10 g ai / ha or more, 12.5 g ai / ha or more, 15 g ai / ha or more, 17.5 g ai / ha or more, 20 g ai / ha or more, 22.5 g ai / ha or more, 25 g ai / ha or more, 27.5 g ai / ha or more, 30 g ai / ha or more, 32.5 g ai / ha or more, 35 g ai / ha or more, 37.5 g ai / ha or more, 40 g ai / ha or more, 42.5 g ai / ha or more, 45 g ai / ha or more, 47.5 g ai / ha or more, 50 g ai / ha or more, 52.5 g ai / ha or more, 55 g ai / ha or more, 57.5 g ai / ha or more, 60 g ai / ha or more, 62.5 g ai / ha or more, 65 g ai / ha or more, 67.5 g ai / ha or more, 70 g ai / ha or more, 72.5 g ai / ha or more, 75 g ai / ha or more, 77.5 g ai / ha or more, 80 g ai / ha or more, 82.5 g ai / ha or more, 85 g ai / ha or more, 87.5 g ai / ha or more, 90 g ai / ha or more, 92.5 g ai / ha or more, 95 g ai / ha or more, 97.5 g ai / ha or more; in an amount of 100 g ai / ha or less, such as 97.5 g ai / ha or less, 95 g ai / ha or less, 92.5 g ai / ha or less, 90 g ai / ha or less, 87.5 g ai / ha or less, 85 g ai / ha or less, 82.5 g ai / ha or less, 80 g ai / ha or less, 77.5 g ai / ha or less, 75 g ai / ha or less, 72.5 g ai / ha or less, 70 g ai / ha or less, 67.5 g ai / ha or less, 65 g ai / ha or less, 62.5 g ai / ha or less, 60 g ai / ha or less, 57.5 g ai / ha or less, 55 g ai / ha or less, 52.5 g ai / ha or less, 50 g ai / ha or less, 47.5 g ai / ha or less, 45 g ai / ha or less, 42.5 g ai / ha or less, 40 g ai / ha or less, 37.5 g ai / ha or less, 35 g ai / ha or less, 32.5 g ai / ha or less, 30 g ai / ha or less, 27.5 g ai / ha or less, 25 g ai / ha or less, 22.5 g ai / ha or less, 20 g ai / ha or less, 17.5 g ai / ha or less, 15 g ai / ha or less, 12.5 g ai / ha or less, 10 g ai / ha or less, or 7.5 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 5–100 g ai / ha, 5–90 g ai / ha, 7.5–45 g ai / ha, 10–55 g ai / ha, 15–90 g ai / ha, 20– 50 g ai / ha, 22.5–90 g ai / ha, 25–52.5 g ai / ha, 25–80 g ai / ha, 25–65 g ai / ha, 27.5–60 g ai / ha, 27.5–47.5 g ai / ha, 30–85 g ai / ha, or 40–95 g ai / ha.

[0013] Pyribenzoxim Compositions and methods of the present disclosure can include pyribenzoxim or an agriculturally acceptable salt or ester thereof. Pyribenzoxim, shown below, is a pyrimidinyl oxybenzoate that provides post-emergence control of barnyard grass, blackgrass and Polygonum species in rice, wheat and zoysiagrass. Pyribenzoxim, as well as methods of preparing pyribenzoxim, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. Pyribenzoxim can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, pyribenzoxim is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 7.5 g ai / ha or more, such as 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, or 69 g ai / ha or more; in an amount of 70 g ai / ha or less, such as 69 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, or 8 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 7.5–70 g ai / ha, 7.5– 68 g ai / ha, 7.5–52 g ai / ha, 8–60 g ai / ha, 9–38 g ai / ha, 9–64 g ai / ha, 10–66 g ai / ha, 10–44 g ai / ha, 10–40 g ai / ha, 11–62 g ai / ha, 12–46 g ai / ha, 13–70 g ai / ha, 15–54 g ai / ha, or 20–64 g ai / ha. Pyriftalid Compositions and methods of the present disclosure can include pyriftalid or an agriculturally acceptable salt or ester thereof. Pyriftalid, shown below, is a pyrimidinyl oxybenzoate that provides control of grass weeds in rice. Pyriftalid, as well as methods of preparing pyriftalid, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. Pyriftalid can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, pyriftalid is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 20 g ai / ha or more, such as 22 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 55 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, 170 g ai / ha or more, 180 g ai / ha or more, 190 g ai / ha or more, 200 g ai / ha or more, 210 g ai / ha or more, 220 g ai / ha or more, 230 g ai / ha or more, 240 g ai / ha or more, 250 g ai / ha or more, 260 g ai / ha or more, 270 g ai / ha or more, 280 g ai / ha or more, 290 g ai / ha or more, 300 g ai / ha or more, 310 g ai / ha or more, 320 g ai / ha or more, 330 g ai / ha or more, 340 g ai / ha or more, or 345 g ai / ha or more; in an amount of 350 g ai / ha or less, such as 345 g ai / ha or less, 340 g ai / ha or less, 330 g ai / ha or less, 320 g ai / ha or less, 310 g ai / ha or less, 300 g ai / ha or less, 290 g ai / ha or less, 280 g ai / ha or less, 270 g ai / ha or less, 260 g ai / ha or less, 250 g ai / ha or less, 240 g ai / ha or less, 230 g ai / ha or less, 220 g ai / ha or less, 210 g ai / ha or less, 200 g ai / ha or less, 190 g ai / ha or less, 180 g ai / ha or less, 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 55 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, or 22 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 20-350 g ai / ha, 55–170 g ai / ha, 22–220 g ai / ha, 70–260 g ai / ha, 30–250 g ai / ha, 45-220 g ai / ha, 80–200 g ai / ha, 130–270 g ai / ha, 150–330 g ai / ha, 60–160 g ai / ha, 180–345 g ai / ha, 210–310 g ai / ha, 90–190 g ai / ha, or 22–340 g ai / ha. Pyriminobac Compositions and methods of the present disclosure can include pyriminobac or an agriculturally acceptable salt or ester thereof. Pyriminobac, shown below, is a pyrimidinyl oxybenzoate that provides post-emergence control of Echinochloa spp., in paddy rice. Pyriminobac, as well as methods of preparing pyriminobac, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. Pyriminobac can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, pyriminobac is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 20 g ai / ha or more, such as 22 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 120 g ai / ha or more, 130 g ai / ha or more, 140 g ai / ha or more, 150 g ai / ha or more, 160 g ai / ha or more, or 170 g ai / ha or more; in an amount of 175 g ai / ha or less, such as 170 g ai / ha or less, 160 g ai / ha or less, 150 g ai / ha or less, 140 g ai / ha or less, 130 g ai / ha or less, 120 g ai / ha or less, 110 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, or 22 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 20–175 g ai / ha, 22–170 g ai / ha, 35–120 g ai / ha, 100–160 g ai / ha, 40–150 g ai / ha, 80-120 g ai / ha, 25–110 g ai / ha, 90–150 g ai / ha, 45–130 g ai / ha, 60–160 g ai / ha, 30–120 g ai / ha, 20–160 g ai / ha, or 22–100 g ai / ha. SULFONYLAMINOCARBONYL TRIAZOLINONE HERBICIDES In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) flucarbazone, propoxycarbazone, thiencarbazone, or agriculturally acceptable salts or esters thereof, or combinations thereof. Flucarbazone Compositions and methods of the present disclosure can include flucarbazone or an agriculturally acceptable salt or ester thereof. Flucarbazone, shown below, is a sulfonylamino- carbonyl triazolinone that provides post-emergence control of annual grass weeds and some perennial grass weeds and some broad-leaved weeds. Flucarbazone, as well as methods of preparing flucarbazone, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Flucarbazone can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, flucarbazone is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 3.75 g ai / ha or more, such as 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 5.25 g ai / ha or more, 5.5 g ai / ha or more, 5.75 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 7.5 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 21 g ai / ha or more, 22 g ai / ha or more, 23 g ai / ha or more, 24 g ai / ha or more, 25 g ai / ha or more, 25.5 g ai / ha or more, 26 g ai / ha or more, 26.5 g ai / ha or more, 27 g ai / ha or more, 27.5 g ai / ha or more, 28 g ai / ha or more, 28.5 g ai / ha or more, 29 g ai / ha or more, 29.25 g ai / ha or more, 29.5 g ai / ha or more, or 29.75 g ai / ha or more; in an amount of 30 g ai / ha or less, such as 29.75 g ai / ha or less, 29.5 g ai / ha or less, 29.25 g ai / ha or less, 29 g ai / ha or less, 28.5 g ai / ha or less, 28 g ai / ha or less, 27.5 g ai / ha or less, 27 g ai / ha or less, 26.5 g ai / ha or less, 26 g ai / ha or less, 25 g ai / ha or less, 24 g ai / ha or less, 23 g ai / ha or less, 22 g ai / ha or less, 21 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7.5 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5.75 g ai / ha or less, 5.5 g ai / ha or less, 5.25 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, or 4 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 3.75–30 g ai / ha, 3.75–27 g ai / ha, 4–28 g ai / ha, 4–20 g ai / ha, 5–29.5 g ai / ha, 5–21 g ai / ha, 5.5–28 g ai / ha, 6–26 g ai / ha, 7– 25 g ai / ha, 7.5–30 g ai / ha, 7.5–21 g ai / ha, 8–25 g ai / ha, 9–19 g ai / ha, or 10–28.5 g ai / ha. Propoxycarbazone Compositions and methods of the present disclosure can include propoxycarbazone or an agriculturally acceptable salt or ester thereof. Propoxycarbazone, shown below, is a sulfonylaminocarbonyl triazolinone that provides post-emergence control of grass weeds and some broad-leaved weeds. Propoxycarbazone, as well as methods of preparing propoxycarbazone, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Propoxycarbazone can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, propoxycarbazone is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 3.75 g ai / ha or more, such as 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 61 g ai / ha or more, 62 g ai / ha or more, 63 g ai / ha or more, 64 g ai / ha or more, 65 g ai / ha or more, 66 g ai / ha or more, 67 g ai / ha or more, 68 g ai / ha or more, or 69 g ai / ha or more; in an amount of 70 g ai / ha or less, such as 69 g ai / ha or less, 68 g ai / ha or less, 67 g ai / ha or less, 66 g ai / ha or less, 65 g ai / ha or less, 64 g ai / ha or less, 63 g ai / ha or less, 62 g ai / ha or less, 61 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 28 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, or 4 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 3.75–70 g ai / ha, 4–68 g ai / ha, 4.25–56 g ai / ha, 4.5– 28 g ai / ha, 5–62 g ai / ha, 5–38 g ai / ha, 7–70 g ai / ha, 8–52 g ai / ha, 9–40 g ai / ha, 10–70 g ai / ha, 10–24 g ai / ha, 12–69 g ai / ha, 14–65 g ai / ha, or 20–58 g ai / ha. Thiencarbazone Compositions and methods of the present disclosure can include thiencarbazone or an agriculturally acceptable salt or ester thereof. Thiencarbazone-methyl, shown below, is a sulfonylaminocarbonyl triazolinone that provides post-emergence control of grass weeds and some broad-leaved weeds. Thiencarbazone, as well as methods of preparing thiencarbazone, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Thiencarbazone can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, thiencarbazone is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.5 g ai / ha or more, such as 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 31 g ai / ha or more, 32 g ai / ha or more, 33 g ai / ha or more, 34 g ai / ha or more, 35 g ai / ha or more, 36 g ai / ha or more, 37 g ai / ha or more, 38 g ai / ha or more, 39 g ai / ha or more, 40 g ai / ha or more, 41 g ai / ha or more, 42 g ai / ha or more, 43 g ai / ha or more, or 44 g ai / ha or more; in an amount of 45 g ai / ha or less, such as 44 g ai / ha or less, 43 g ai / ha or less, 42 g ai / ha or less, 41 g ai / ha or less, 40 g ai / ha or less, 39 g ai / ha or less, 38 g ai / ha or less, 37 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less, 34 g ai / ha or less, 33 g ai / ha or less, 32 g ai / ha or less, 31 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, or 2.75 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.5–45 g ai / ha, 2.5–41 g ai / ha, 2.75–39 g ai / ha, 2.75–37 g ai / ha, 3–40 g ai / ha, 3–33 g ai / ha, 3.25–28 g ai / ha, 3.5–45 g ai / ha, 3.75–45 g ai / ha, 4–39 g ai / ha, 4.5–31 g ai / ha, 5–45 g ai / ha, 5–37 g ai / ha, or 8–36 g ai / ha. SULFONYLUREA HERBICIDES In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) amidosulfuron, azimsulfuron, bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethametsulfuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, iodosulfuron, iofensulfuron, mesosulfuron, metazosulfuron, metsulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, propyrisulfuron, prosulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, triasulfuron, tribenuron, thifensulfuron, trifloxysulfuron, triflusulfuron, tritosulfuron, or agriculturally acceptable salts or esters thereof, or combinations thereof. Amidosulfuron Compositions and methods of the present disclosure can include amidosulfuron or an agriculturally acceptable salt or ester thereof. Amidosulfuron, shown below, is a sulfonylurea that provides post-emergence control of a wide range of broadleaf weeds, e.g., cleavers, in winter wheat, durum wheat, barley, rye, triticale and oats. Amidosulfuron, as well as methods of preparing amidosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Amidosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, amidosulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 3.75 g ai / ha or more, such as 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 51 g ai / ha or more, 52 g ai / ha or more, 53 g ai / ha or more, 54 g ai / ha or more, 55 g ai / ha or more, 56 g ai / ha or more, 57 g ai / ha or more, 58 g ai / ha or more, or 59 g ai / ha or more; in an amount of 60 g ai / ha or less, such as 59 g ai / ha or less, 58 g ai / ha or less, 57 g ai / ha or less, 56 g ai / ha or less, 55 g ai / ha or less, 54 g ai / ha or less, 53 g ai / ha or less, 52 g ai / ha or less, 51 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, or 4.25 g ai / ha or less, or 4 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 3.75–60 g ai / ha, 4–58 g ai / ha, 4.5–51 g ai / ha, 5–57 g ai / ha, 5–30 g ai / ha, 6–42 g ai / ha, 8–50 g ai / ha, 9–32 g ai / ha, 10–53 g ai / ha, 12–30 g ai / ha, or 13–40 g ai / ha. Azimsulfuron Compositions and methods of the present disclosure can include azimsulfuron or an agriculturally acceptable salt or ester thereof. Azimsulfuron, shown below, is a sulfonylurea that provides e.g., post-emergence control of annual and perennial broadleaf and sedge weeds in rice. Azimsulfuron, as well as methods of preparing azimsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Azimsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, azimsulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 3.125 g ai / ha or more, such as 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 5.5 g ai / ha or more, 6 g ai / ha or more, 6.5 g ai / ha or more, 7 g ai / ha or more, 7.5 g ai / ha or more, 8 g ai / ha or more, 8.5 g ai / ha or more, 9 g ai / ha or more, 9.5 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 20.5 g ai / ha or more, 21 g ai / ha or more, 21.5 g ai / ha or more, 22 g ai / ha or more, 22.5 g ai / ha or more, 22.75 g ai / ha or more, 23 g ai / ha or more, 23.25 g ai / ha or more, 23.5 g ai / ha or more, 23.75 g ai / ha or more, 24 g ai / ha or more, 24.25 g ai / ha or more, 24.5 g ai / ha or more, or 24.75 g ai / ha or more; in an amount of 25 g ai / ha or less, such as 24.75 g ai / ha or less, 24.5 g ai / ha or less, 24.25 g ai / ha or less, 24 g ai / ha or less, 23.75 g ai / ha or less, 23.5 g ai / ha or less, 23.25 g ai / ha or less, 23 g ai / ha or less, 22.75 g ai / ha or less, 22.5 g ai / ha or less, 22 g ai / ha or less, 21.5 g ai / ha or less, 21 g ai / ha or less, 20.5 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9.5 g ai / ha or less, 9 g ai / ha or less, 8.5 g ai / ha or less, 8 g ai / ha or less, 7.5 g ai / ha or less, 7 g ai / ha or less, 6.5 g ai / ha or less, 6 g ai / ha or less, 5.5 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, or 3.25 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 3.125–25 g ai / ha, 3.125–23.5 g ai / ha, 3.125–19 g ai / ha, 3.25–22 g ai / ha, 3.5–24.5 g ai / ha, 3.5–19 g ai / ha, 3.75–22 g ai / ha, 4–25 g ai / ha, 4–23.25 g ai / ha, 4.25–20 g ai / ha, 4.5–18 g ai / ha, 4.75–22.75 g ai / ha, or 5–24 g ai / ha. Bensulfuron Compositions and methods of the present disclosure can include bensulfuron or an agriculturally acceptable salt or ester thereof. Bensulfuron-methyl, shown below, is a sulfonylurea that provides e.g., pre- and post-emergence control of annual and perennial broadleaf weeds and sedges in rice. Bensulfuron, as well as methods of preparing bensulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Bensulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, bensulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 8.75 g ai / ha or more, such as 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, or 69 g ai / ha or more; in an amount of 70 g ai / ha or less, such as 69 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, or 9 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 8.75–70 g ai / ha, 9–60 g ai / ha, 10–65 g ai / ha, 10–40 g ai / ha, 10–28 g ai / ha, 11–68 g ai / ha, 11–54 g ai / ha, 12–60 g ai / ha, 12–42 g ai / ha, 13–69 g ai / ha, 14–56 g ai / ha, 15–40 g ai / ha, 20–46 g ai / ha, or 20–69 g ai / ha. Chlorsulfuron Compositions and methods of the present disclosure can include chlorsulfuron or an agriculturally acceptable salt or ester thereof. Chlorsulfuron, shown below, is a sulfonylurea that provides control of e.g., broadleaf weeds and annual grasses in wheat, barley, oats, rye, triticale, flax and on non-crop land. Chlorsulfuron, as well as methods of preparing chlorsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Chlorsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, chlorsulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1.1 g ai / ha or more, such as 1.25 g ai / ha or more, ., 1.5 g ai / ha or more, 1.75 g ai / ha or more, 2 g ai / ha or more, 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 47 g ai / ha or more, 48 g ai / ha or more, 49 g ai / ha or more, 50 g ai / ha or more, 51 g ai / ha or more, or 51.5 g ai / ha or more; in an amount of 52 g ai / ha or less, such as 51.5 g ai / ha or less, 51 g ai / ha or less, 50 g ai / ha or less, 49 g ai / ha or less, 48 g ai / ha or less, 47 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, or 4.25 g ai / ha or less, ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, 2.25 g ai / ha or less, 2 g ai / ha or less, 1.75 g ai / ha or less, 1.5 g ai / ha or less, or 1.25 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1.1–52 g ai / ha,1.25–51.5 g ai / ha, 1.5–30 g ai / ha, 1.75–47 g ai / ha, 2–26 g ai / ha, 3–50 g ai / ha, 4–38 g ai / ha, 4.5–42 g ai / ha, 5–51 g ai / ha, 7–49 g ai / ha, 9–32 g ai / ha, 10–45 g ai / ha, 12–52 g ai / ha, or 15–48 g ai / ha. Ethoxysulfuron Compositions and methods of the present disclosure can include ethoxysulfuron or an agriculturally acceptable salt or ester thereof. Ethoxysulfuron, shown below, is a sulfonylurea that provides e.g., control of broadleaf and sedge weeds in cereals, rice and sugar cane. Ethoxysulfuron, as well as methods of preparing ethoxysulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Ethoxysulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, ethoxysulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 5 g ai / ha or more, such as 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 55 g ai / ha or more, 60 g ai / ha or more, 65 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 85 g ai / ha or more, 90 g ai / ha or more, 95 g ai / ha or more, 100 g ai / ha or more, 101 g ai / ha or more, 102 g ai / ha or more, 103 g ai / ha or more, 104 g ai / ha or more, 105 g ai / ha or more, 106 g ai / ha or more, 107 g ai / ha or more, 108 g ai / ha or more, 109 g ai / ha or more, 110 g ai / ha or more, 111 g ai / ha or more, 112 g ai / ha or more, 113 g ai / ha or more, 114 g ai / ha or more, 115 g ai / ha or more, 116 g ai / ha or more, 117 g ai / ha or more, 118 g ai / ha or more, or 119 g ai / ha or more; in an amount of 120 g ai / ha or less, such as 119 g ai / ha or less, 118 g ai / ha or less, 117 g ai / ha or less, 116 g ai / ha or less, 115 g ai / ha or less, 114 g ai / ha or less, 113g ai / ha or less, 112 g ai / ha or less, 111 g ai / ha or less, 110 g ai / ha or less, 109 g ai / ha or less, 108 g ai / ha or less, 107 g ai / ha or less, 106 g ai / ha or less, 105 g ai / ha or less, 104 g ai / ha or less, 103 g ai / ha or less, 102 g ai / ha or less, 101 g ai / ha or less, 100 g ai / ha or less, 95 g ai / ha or less, 90 g ai / ha or less, 85 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 65 g ai / ha or less, 60 g ai / ha or less, 55 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, or 6 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 5–120 g ai / ha, 5–90 g ai / ha, 5–75 g ai / ha, 6–114 g ai / ha, 8–108 g ai / ha, 9–113 g ai / ha, 10–80 g ai / ha, 10–55 g ai / ha, 12–112 g ai / ha, 13–85 g ai / ha, 15–106 g ai / ha, 20–100 g ai / ha, 24–105 g ai / ha, or 28–115 g ai / ha. Flupyrsulfuron Compositions and methods of the present disclosure can include flupyrsulfuron or an agriculturally acceptable salt or ester thereof. Flupyrsulfuron-methyl sodium, shown below, is a sulfonylurea that is used, e.g., for post-emergent control of grass and broadleaf weeds in cereals. Flupyrsulfuron, as well as methods of preparing flupyrsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Flupyrsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, flupyrsulfuron thereof is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 2.5 g ai / ha or more, such as 2.6 g ai / ha or more, 2.7 g ai / ha or more, 2.8 g ai / ha or more, 2.9 g ai / ha or more, 3.0 g ai / ha or more, 3.2 g ai / ha or more, 3.4 g ai / ha or more, 3.6 g ai / ha or more, 3.8 g ai / ha or more, 4 g ai / ha or more, 4.2 g ai / ha or more, 4.4 g ai / ha or more, 4.6 g ai / ha or more, 4.8 g ai / ha or more, 5 g ai / ha or more, 5.2 g ai / ha or more, 5.4 g ai / ha or more, 5.6 g ai / ha or more, 5.8 g ai / ha or more, 6 g ai / ha or more, 6.2 g ai / ha or more, 6.4 g ai / ha or more, 6.6 g ai / ha or more, 6.8 g ai / ha or more, 7 g ai / ha or more, 7.2 ai / ha or more, 7.4 g ai / ha or more, 7.6 g ai / ha or more, 8 g ai / ha or more, 8.2 g ai / ha or more, 8.4 ai / ha or more, 8.6 g ai / ha or more, 8.8 g ai / ha or more, 9 g ai / ha or more, 9.1 g ai / ha or more, 9.2 g ai / ha or more,9.3 g ai / ha or more, 9.4 g ai / ha or more, 9.5 g ai / ha or more, 9.6 g ai / ha or more, 9.7 g ai / ha or more, 9.8 g ai / ha or more, or 9.9 g ai / ha or more; in an amount of 10 g ai / ha or less, such as 9.9 g ai / ha or less, 9.8 g ai / ha or less, 9.7 g ai / ha or less, 9.6 g ai / ha or less, 9.5 g ai / ha or less, 9.4 g ai / ha or less, 9.3 g ai / ha or less, 9.2 g ai / ha or less, 9.1 g ai / ha or less, 9 g ai / ha or less, 8.8 g ai / ha or less, 8.6 g ai / ha or less, 8.4 g ai / ha or less, 8.2 g ai / ha or less, 8 g ai / ha or less, 7.8 g ai / ha or less, 7.6 g ai / ha or less, 7.4 g ai / ha or less, 7.2 g ai / ha or less, 7 g ai / ha or less, 6.8 g ai / ha or less, 6.6 g ai / ha or less, 6.4 g ai / ha or less, 6.2 g ai / ha or less, 6 g ai / ha or less, 5.8 g ai / ha or less, 5.6 g ai / ha or less, 5.4 g ai / ha or less, 5.2 g ai / ha or less, 5 g ai / ha or less, 4.8 g ai / ha or less, 4.6 g ai / ha or less, 4.4 g ai / ha or less, 4.2 g ai / ha or less, 4 g ai / ha or less, 3.8 g ai / ha or less, 3.6 g ai / ha or less, 3.4 g ai / ha or less, 3.2 g ai / ha or less, 3 g ai / ha or less, 2.9 g ai / ha or less, 2.8 g ai / ha or less, 2.7 g ai / ha or less, or 2.6 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 2.5–10 g ai / ha, 2.5–9.4 g ai / ha, 2.6–9 g ai / ha, 2.7–10 g ai / ha, 2.8–9.4 g ai / ha, 3–8.8 g ai / ha, 3.2–7.2 g ai / ha, 3.4–8.6 g ai / ha, 3.6–10 g ai / ha, 3.8–9.5 g ai / ha, 4–8.8 g ai / ha, 4.4–7 g ai / ha, 4.6–6.8 g ai / ha, or 5–9.5 g ai / ha. Foramsulfuron Compositions and methods of the present disclosure can include foramsulfuron or an agriculturally acceptable salt or ester thereof. Foramsulfuron, shown below, is a sulfonylurea that provides e.g., post-emergence control of grass and broadleaf weeds in maize. Foramsulfuron, as well as methods of preparing foramsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Foramsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, foramsulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 22.5 g ai / ha or more, such as 23 g ai / ha or more, 24 g ai / ha or more, 25 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 35 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 51 g ai / ha or more, 52 g ai / ha or more, 53 g ai / ha or more, 54 g ai / ha or more, 55 g ai / ha or more, 56 g ai / ha or more, 57 g ai / ha or more, or 58 g ai / ha or more; in an amount of 59 g ai / ha or less, such as 58 g ai / ha or less, 57 g ai / ha or less, 56 g ai / ha or less, 55 g ai / ha or less, 54 g ai / ha or less, 53 g ai / ha or less, 52 g ai / ha or less, 51 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 25 g ai / ha or less, 24 g ai / ha or less, or 23 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 22.5–59 g ai / ha, 23–51 g ai / ha, 25–38 g ai / ha, 26–57 g ai / ha, 28–48 g ai / ha, 30–58 g ai / ha, 30–50 g ai / ha, 32–55 g ai / ha, 34–57 g ai / ha, or 35–58 g ai / ha.

[0014] Halosulfuron Compositions and methods of the present disclosure can include halosulfuron or an agriculturally acceptable salt or ester thereof. Halosulfuron-methyl, shown below, is a sulfonylurea that has demonstrated activity for the control of annual broadleaf weeds and nutsedge species, in maize, sugar cane, rice, sorghum, nuts, and turf. Halosulfuron, as well as methods of preparing halosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Halosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, halosulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 4.375 g ai / ha or more, such as 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 55 g ai / ha or more, 60 g ai / ha or more, 65 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 85 g ai / ha or more, 90 g ai / ha or more, 95 g ai / ha or more, 100 g ai / ha or more, 105 g ai / ha or more, 110 g ai / ha or more, 115 g ai / ha or more, 120 g ai / ha or more, 122 g ai / ha or more, 124 g ai / ha or more, 126 g ai / ha or more, 128 g ai / ha or more, 130 g ai / ha or more, 131 g ai / ha or more, 132 g ai / ha or more, 133 g ai / ha or more, 134 g ai / ha or more, 135 g ai / ha or more, 136 g ai / ha or more, 137 g ai / ha or more, 138 g ai / ha or more, or 139 g ai / ha or more; in an amount of 139 g ai / ha or less, such as 138 g ai / ha or less, 137 g ai / ha or less, 136 g ai / ha or less, 135 g ai / ha or less, 134 g ai / ha or less, 133 g ai / ha or less, 132 g ai / ha or less, 131 g ai / ha or less, 130 g ai / ha or less, 129 g ai / ha or less, 128 g ai / ha or less, 126 g ai / ha or less, 124 g ai / ha or less, 122 g ai / ha or less, 120 g ai / ha or less, 115 g ai / ha or less, 110 g ai / ha or less, 105 g ai / ha or less, 100 g ai / ha or less, 95 g ai / ha or less, 90 g ai / ha or less, 85 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 65 g ai / ha or less, 60 g ai / ha or less, 55 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, or 4.5 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 4.375–140 g ai / ha, 4.5–120 g ai / ha, 4.75–100 g ai / ha, 5–95 g ai / ha, 5–131 g ai / ha, 6–80 g ai / ha, 7–130 g ai / ha, 8–122 g ai / ha, 9–75 g ai / ha, 10– 139 g ai / ha, 15–90 g ai / ha, 20–124 g ai / ha, 25–110 g ai / ha, or 25–75 g ai / ha. Iodosulfuron Compositions and methods of the present disclosure can include iodosulfuron or an agriculturally acceptable salt or ester thereof. Iodosulfuron-methyl-sodium, shown below, is a sulfonylurea that provides, e.g., post-emergence control of grass and broadleaf weeds in winter, spring and durum wheat, triticale, rye and spring barley. Iodosulfuron, as well as methods of preparing iodosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Iodosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, iodosulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 0.1 g ai / ha or more, such as 0.2 g ai / ha or greater, 0.3 g ai / ha or greater, 0.4 g ai / ha or greater, 0.5 g ai / ha or greater, 0.6 g ai / ha or greater, 0.7 g ai / ha or greater, 0.8 g ai / ha or greater, 0.9 g ai / ha or greater, 1 g ai / ha or greater, 1.1 g ai / ha or greater, 1.2 g ai / ha or greater, 1.3 g ai / ha or greater, 1.4 g ai / ha or more, 1.5 g ai / ha or more, 1.6 g ai / ha or more, 1.7 g ai / ha or more, 1.8 g ai / ha or more, 1.9 g ai / ha or more, 2.0 g ai / ha or more, 2.1 g ai / ha or more, 2.2 g ai / ha or more, 2.3 g ai / ha or more, 2.3 g ai / ha or more, 2.4 g ai / ha or more, 2.5 g ai / ha or more, 2.6 g ai / ha or more, 2.7 g ai / ha or more, 2.8 g ai / ha or more, 2.9 g ai / ha or more, 3.0 g ai / ha or more, 3.2 g ai / ha or more, 3.4 g ai / ha or more, 3.6 g ai / ha or more, 3.8 g ai / ha or more, 4 g ai / ha or more, 4.2 g ai / ha or more, 4.4 g ai / ha or more, 4.6 g ai / ha or more, 4.8 g ai / ha or more, 5 g ai / ha or more, 5.2 g ai / ha or more, 5.4 g ai / ha or more, 5.6 g ai / ha or more, 5.8 g ai / ha or more, 6 g ai / ha or more, 6.2 g ai / ha or more, 6.4 g ai / ha or more, 6.6 g ai / ha or more, 6.8 g ai / ha or more, 7 g ai / ha or more, 7.2 ai / ha or more, 7.4 g ai / ha or more, 7.6 g ai / ha or more, 8 g ai / ha or more, 8.2 g ai / ha or more, 8.4 ai / ha or more, 8.6 g ai / ha or more, 8.8 g ai / ha or more, 9 g ai / ha or more, 9.1 g ai / ha or more, 9.2 g ai / ha or more, 9.3 g ai / ha or more, 9.4 g ai / ha or more, 9.5 g ai / ha or more, 9.6 g ai / ha or more, 9.7 g ai / ha or more, 9.8 g ai / ha or more, or 9.9 g ai / ha or more; in an amount of 10 g ai / ha or less, such as 9.9 g ai / ha or less, 9.8 g ai / ha or less, 9.7 g ai / ha or less, 9.6 g ai / ha or less, 9.5 g ai / ha or less, 9.4 g ai / ha or less, 9.3 g ai / ha or less, 9.2 g ai / ha or less, 9.1 g ai / ha or less, 9 g ai / ha or less, 8.8 g ai / ha or less, 8.6 g ai / ha or less, 8.4 g ai / ha or less, 8.2 g ai / ha or less, 8 g ai / ha or less, 7.8 g ai / ha or less, 7.6 g ai / ha or less, 7.4 g ai / ha or less, 7.2 g ai / ha or less, 7 g ai / ha or less, 6.8 g ai / ha or less, 6.6 g ai / ha or less, 6.4 g ai / ha or less, 6.2 g ai / ha or less, 6 g ai / ha or less, 5.8 g ai / ha or less, 5.6 g ai / ha or less, 5.4 g ai / ha or less, 5.2 g ai / ha or less, 5 g ai / ha or less, 4.8 g ai / ha or less, 4.6 g ai / ha or less, 4.4 g ai / ha or less, 4.2 g ai / ha or less, 4 g ai / ha or less, 3.8 g ai / ha or less, 3.6 g ai / ha or less, 3.4 g ai / ha or less, 3.2 g ai / ha or less, 3 g ai / ha or less, 2.9 g ai / ha or less, 2.8 g ai / ha or less, 2.7 g ai / ha or less, 2.6 g ai / ha or less, 2.5 g ai / ha or less, 2.4 g ai / ha or less, 2.3 g ai / ha or less, 2.2 g ai / ha or less, 2.1 g ai / ha or less, 2.0 g ai / ha or less, 1.9 g ai / ha or less, 1.8 g ai / ha or less, 1.7 g ai / ha or less, 1.6 g ai / ha or less, 1.5 g ai / ha or less, 1.4 g ai / ha or less, 1.3 g ai / ha or less, 1.2 g ai / ha or less, 1.1 g ai / ha or less, 1 g ai / ha or less, 0.9 g ai / ha or less, 0.8 g ai / ha or less, 0.7 g ai / ha or less, 0.6 g ai / ha or less, 0.5 g ai / ha or less, 0.4 g ai / ha or less, 0.3 g ai / ha or less, or 0.2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 0.1–10 g ai / ha, 0.4– 8.8 g ai / ha, 1.1–6.2 g ai / ha, 1.7–7.5 g ai / ha, 1.8–9.2 g ai / ha, 1.9–9 g ai / ha, 2–6.8 g ai / ha, 2.2– 9.5 g ai / ha, 2.5–10 g ai / ha, 2.8–7.6 g ai / ha, 3–9.4 g ai / ha, 3.2–7.2 g ai / ha, 3.4–10 g ai / ha, or 3.6–8 g ai / ha. Mesosulfuron Compositions and methods of the present disclosure can include mesosulfuron or an agriculturally acceptable salt or ester thereof. Mesosulfuron-methyl, shown below, is a sulfonylurea that provides, e.g., early- to mid-post-emergence control of grass and some broadleaf weeds in winter, spring and durum wheat, triticale and rye. Mesosulfuron, as well as methods of preparing mesosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Mesosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, mesosulfuron thereof is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1.5 g ai / ha or more, such as 1.6 g ai / ha or more, 1.7 g ai / ha or more, 1.8 g ai / ha or more, 1.9 g ai / ha or more, 2 g ai / ha or more, 2.1 g ai / ha or more, 2.25 g ai / ha or more, 2.5 g ai / ha or more, 2.75 g ai / ha or more, 3 g ai / ha or more, 3.25 g ai / ha or more, 3.5 g ai / ha or more, 3.75 g ai / ha or more, 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 31 g ai / ha or more, 32 g ai / ha or more, 33 g ai / ha or more, 34 g ai / ha or more, 35 g ai / ha or more, 36 g ai / ha or more, 37 g ai / ha or more, 38 g ai / ha or more, 39 g ai / ha or more, 40 g ai / ha or more, 41 g ai / ha or more, 42 g ai / ha or more, 43 g ai / ha or more, or 44 g ai / ha or more; in an amount of 45 g ai / ha or less, such as 44 g ai / ha or less, 43 g ai / ha or less, 42 g ai / ha or less, 41 g ai / ha or less, 40 g ai / ha or less, 39 g ai / ha or less, 38 g ai / ha or less, 37 g ai / ha or less, 36 g ai / ha or less, 35 g ai / ha or less, 34 g ai / ha or less, 33 g ai / ha or less, 32 g ai / ha or less, 31 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, 4 g ai / ha or less, 3.75 g ai / ha or less, 3.5 g ai / ha or less, 3.25 g ai / ha or less, 3 g ai / ha or less, 2.75 g ai / ha or less, 2.5 g ai / ha or less, 2.25 g ai / ha or less, 2.1 g ai / ha or less, 2 g ai / ha or less, 1.9 g ai / ha or less, 1.8 g ai / ha or less, 1.7 g ai / ha or less, 1.6 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1.5–45 g ai / ha, 1.6– 42 g ai / ha, 1.5–40 g ai / ha, 1.7–43 g ai / ha, 1.8–35 g ai / ha, 2–37 g ai / ha, 2.25–41 g ai / ha, 2.5–32 g ai / ha, 2.75–45 g ai / ha, 3–40 g ai / ha, 3–33 g ai / ha, 3–24 g ai / ha, 3.5–45 g ai / ha, or 4–39 g ai / ha. Metsulfuron Compositions and methods of the present disclosure can include metsulfuron or an agriculturally acceptable salt or ester thereof. Metsulfuron-methyl, shown below, is a sulfonylurea that controls, e.g., grass and broadleaf weeds in wheat, barley, rice, oats and triticale. Metsulfuron, as well as methods of preparing metsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Metsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, metsulfuron thereof is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more, such as 1.1 g ai / ha or more,1.2 g ai / ha or more, 1.25 g ai / ha or more, 1.3 g ai / ha or more,1.4 g ai / ha or more, 1.5 g ai / ha or more, 1.6 g ai / ha or more, 1.7 g ai / ha or more, 1.8 g ai / ha or more, 1.9 g ai / ha or more, 2 g ai / ha or more, 2.1 g ai / ha or more, 2.2 g ai / ha or more, 2.3 g ai / ha or more, 2.3 g ai / ha or more, 2.4 g ai / ha or more, 2.5 g ai / ha or more, 2.6 g ai / ha or more, 2.7 g ai / ha or more, 2.8 g ai / ha or more, 2.9 g ai / ha or more, 3 g ai / ha or more, 3.2 g ai / ha or more, 3.4 g ai / ha or more, 3.6 g ai / ha or more, 3.8 g ai / ha or more, 4 g ai / ha or more, 4.2 g ai / ha or more, 4.4 g ai / ha or more, 4.6 g ai / ha or more, 4.8 g ai / ha or more, 5 g ai / ha or more, 5.2 g ai / ha or more, 5.4 g ai / ha or more, 5.6 g ai / ha or more, 5.8 g ai / ha or more, 6 g ai / ha or more, 6.2 g ai / ha or more, 6.4 g ai / ha or more, 6.6 g ai / ha or more, 6.8 g ai / ha or more, 7 g ai / ha or more, 7.2 ai / ha or more, 7.4 g ai / ha or more, 7.6 g ai / ha or more, 7.8 g ai / ha or more, 8 g ai / ha or more, 8.2 g ai / ha or more, 8.4 ai / ha or more, 8.6 g ai / ha or more, 8.8 g ai / ha or more, 9 g ai / ha or more, 9.2 g ai / ha or more, 9.4 g ai / ha or more, 9.6 g ai / ha or more, 9.8 g ai / ha or more, 10 g ai / ha or more, 10.2 g ai / ha or more, 10.4 g ai / ha or more, 10.6 g ai / ha or more, 10.8 g ai / ha or more, 11 g ai / ha or more, 11.1 g ai / ha or more, 11.2 g ai / ha or more, 11.3 g ai / ha or more, 11.4 g ai / ha or more, 11.5 g ai / ha or more, 11.6 g ai / ha or more, 11.7 g ai / ha or more, 11.8 g ai / ha or more, or 11.9 g ai / ha or more; in an amount of 12 g ai / ha or less, such as 11.9 g ai / ha or less, 11.8 g ai / ha or less, 11.7 g ai / ha or less, 11.6 g ai / ha or less, 11.5 g ai / ha or less, 11.4 g ai / ha or less, 11.3 g ai / ha or less, 11.2 g ai / ha or less, 11.1 g ai / ha or less, 11 g ai / ha or less, 10.8 g ai / ha or less, 10.6 g ai / ha or less, 10.4 g ai / ha or less, 10.2 g ai / ha or less, 10 g ai / ha or less, 9.8 g ai / ha or less, 9.6 g ai / ha or less, 9.4 g ai / ha or less, 9.2 g ai / ha or less, 9 g ai / ha or less, 8.8 g ai / ha or less, 8.6 g ai / ha or less, 8.4 g ai / ha or less, 8.2 g ai / ha or less, 8 g ai / ha or less, 7.8 g ai / ha or less, 7.6 g ai / ha or less, 7.4 g ai / ha or less, 7.2 g ai / ha or less, 7 g ai / ha or less, 6.8 g ai / ha or less, 6.6 g ai / ha or less, 6.4 g ai / ha or less, 6.2 g ai / ha or less, 6 g ai / ha or less, 5.8 g ai / ha or less, 5.6 g ai / ha or less, 5.4 g ai / ha or less, 5.2 g ai / ha or less, 5 g ai / ha or less, 4.8 g ai / ha or less, 4.6 g ai / ha or less, 4.4 g ai / ha or less, 4.2 g ai / ha or less, 4 g ai / ha or less, 3.8 g ai / ha or less, 3.6 g ai / ha or less, 3.4 g ai / ha or less, 3.2 g ai / ha or less, 3 g ai / ha or less, 2.9 g ai / ha or less, 2.8 g ai / ha or less, 2.7 g ai / ha or less, 2.6 g ai / ha or less, 2.5 g ai / ha or less, 2.4 g ai / ha or less, 2.3 g ai / ha or less, 2.2 g ai / ha or less, 2.1 g ai / ha or less, 2 g ai / ha or less, 1.9 g ai / ha or less, 1.8 g ai / ha, 1.7 g ai / ha or less, 1.6 g ai / ha or less, 1.5 g ai / ha or less, 1.4 g ai / ha or less, 1.3 g ai / ha or less, 1.25 g ai / ha or less, 1.2 g ai / ha or less, or 1.1 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–12 g ai / ha, 1–10 g ai / ha, 1.1–9.4 g ai / ha, 1.25–8.2 g ai / ha, 1.25–11 g ai / ha, 1.3–7 g ai / ha, 1.4–5.8 g ai / ha, 1.5–12 g ai / ha, 1.5–10.4 g ai / ha, 1.5–8.8 g ai / ha, 2–11.7 g ai / ha, 2.2–6.4 g ai / ha, 2.5–7.6 g ai / ha, 2.8–12 g ai / ha, or 3–8 g ai / ha. Nicosulfuron Compositions and methods of the present disclosure can include nicosulfuron or an agriculturally acceptable salt or ester thereof. Nicosulfuron, shown below, is a sulfonylurea that provides e.g., selective post-emergence control in maize of annual grass weeds, including Setaria, Echinochloa, Digitaria, Panicum, Lolium and Avena spp., broadleaf weeds, including Amaranthus spp. and Cruciferae, and perennials such as Sorghum halepense and Agropyron repens. Nicosulfuron, as well as methods of preparing nicosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Nicosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, nicosulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 8.75 g ai / ha or more, such as 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, or 69 g ai / ha or more; in an amount of 70 g ai / ha or less, such as 69 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, or 9 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 8.75–70 g ai / ha, 9–68 g ai / ha, 10–50 g ai / ha, 12–66 g ai / ha, 14–44 g ai / ha, 15–58 g ai / ha, 18–65 g ai / ha, 20–45 g ai / ha, 22–60 g ai / ha, 26–56 g ai / ha, or 30–70 g ai / ha. Orthosulfamuron Compositions and methods of the present disclosure can include orthosulfamuron or an agriculturally acceptable salt or ester thereof. Orthosulfamuron, shown below, is a sulfonylurea that provides e.g., early post-emergence control of annual and perennial broadleaf weeds and sedges in rice, cereals, pastures and sugar cane. Orthosulfamuron, as well as methods of preparing orthosulfamuron, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. Orthosulfamuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, orthosulfamuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 7.5 g ai / ha or more, such as 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, 70 g ai / ha or more, 71 g ai / ha or more, 72 g ai / ha or more, 73 g ai / ha or more, or 74 g ai / ha or more; in an amount of 75 g ai / ha or less, such as 74 g ai / ha or less, 72 g ai / ha or less, 70 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, or 8 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 7.5–75 g ai / ha, 7.5–60 g ai / ha, 8–58 g ai / ha, 9–42 g ai / ha, 10–70 g ai / ha, 10–56 g ai / ha, 11–40 g ai / ha, 13–64 g ai / ha, 15–75 g ai / ha, 17–46 g ai / ha, 20–65 g ai / ha, 20–52 g ai / ha, 22–48 g ai / ha, or 24–74 g ai / ha. Rimsulfuron Compositions and methods of the present disclosure can include rimsulfuron or an agriculturally acceptable salt or ester thereof. Rimsulfuron, shown below, is a sulfonylurea that provides post-emergence control of most annual and perennial grass weeds and several broad-leaved weeds in maize, tomatoes and potatoes, at 15 g / ha. Rimsulfuron, as well as methods of preparing rimsulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Rimsulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, rimsulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 5 g ai / ha or more, such as 5.5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 7.5 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 27 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, 69 g ai / ha or more, 70 g ai / ha or more, 71 g ai / ha or more, 72 g ai / ha or more, 73 g ai / ha or more, or 74 g ai / ha or more; in an amount of 75 g ai / ha or less, such as 74 g ai / ha or less, 73 g ai / ha or less, 72 g ai / ha or less, 71 g ai / ha or less, 70 g ai / ha or less, 69 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 27 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7.5 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5.5 g ai / ha or less, or 5 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 5–75 g ai / ha, 7.5–70 g ai / ha, 9–64 g ai / ha, 18–69 g ai / ha, 27–36 g ai / ha, 5.5–66 g ai / ha, 14–18 g ai / ha, 27- 69 g ai / ha, 7–38 g ai / ha, 12–52 g ai / ha, 9–44 g ai / ha, 10–38 g ai / ha, 16–75 g ai / ha, or 20–48 g ai / ha. Sulfosulfuron Compositions and methods of the present disclosure can include sulfosulfuron or an agriculturally acceptable salt or ester thereof. Sulfosulfuron, shown below, is a sulfonylurea that provides e.g., control of annual broadleaf weeds and grass weeds in cereals. Sulfosulfuron, as well as methods of preparing sulfosulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Sulfosulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, sulfosulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 4.375 g ai / ha or more, such as 4.75 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 12 g ai / ha or more, 14 g ai / ha or more, 16 g ai / ha or more, 18 g ai / ha or more, 20 g ai / ha or more, 22 g ai / ha or more, 24 g ai / ha or more, 26 g ai / ha or more, 28 g ai / ha or more, 30 g ai / ha or more, 32 g ai / ha or more, 34 g ai / ha or more, 36 g ai / ha or more, 38 g ai / ha or more, 40 g ai / ha or more, 42 g ai / ha or more, 44 g ai / ha or more, 46 g ai / ha or more, 48 g ai / ha or more, 50 g ai / ha or more, 52 g ai / ha or more, 54 g ai / ha or more, 56 g ai / ha or more, 58 g ai / ha or more, 60 g ai / ha or more, 62 g ai / ha or more, 64 g ai / ha or more, 66 g ai / ha or more, 68 g ai / ha or more, 70 g ai / ha or more, 71 g ai / ha or more, 72 g ai / ha or more, 73 g ai / ha or more, or 74 g ai / ha or more; in an amount of 75 g ai / ha or less, such as 74 g ai / ha or less, 73 g ai / ha or less, 72 g ai / ha or less, 71 g ai / ha or less, 70 g ai / ha or less, 68 g ai / ha or less, 66 g ai / ha or less, 64 g ai / ha or less, 62 g ai / ha or less, 60 g ai / ha or less, 58 g ai / ha or less, 56 g ai / ha or less, 54 g ai / ha or less, 52 g ai / ha or less, 50 g ai / ha or less, 48 g ai / ha or less, 46 g ai / ha or less, 44 g ai / ha or less, 42 g ai / ha or less, 40 g ai / ha or less, 38 g ai / ha or less, 36 g ai / ha or less, 34 g ai / ha or less, 32 g ai / ha or less, 30 g ai / ha or less, 28 g ai / ha or less, 26 g ai / ha or less, 24 g ai / ha or less, 22 g ai / ha or less, 20 g ai / ha or less, 18 g ai / ha or less, 16 g ai / ha or less, 14 g ai / ha or less, 12 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, or 4.75 g ai / ha or less, or 4.5 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above such as 4.375–75 g ai / ha, 4.5–70 g ai / ha, 4.75–64 g ai / ha, 5–75 g ai / ha, 5–73 g ai / ha, 5–66 g ai / ha, 5–40 g ai / ha, 6–75 g ai / ha, 7–68 g ai / ha, 7–52 g ai / ha, 9–44 g ai / ha, 10– 50 g ai / ha, 16–75 g ai / ha, or 20–60 g ai / ha. Thifensulfuron Compositions and methods of the present disclosure can include thifensulfuron or an agriculturally acceptable salt or ester thereof. Thifensulfuron-methyl, shown below, is a sulfonylurea that provides e.g., control of annual weeds in cereals, maize and pasture. Thifensulfuron, as well as methods of preparing thifensulfuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Thifensulfuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, thifensulfuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 4.4 g ai / ha or more, such as 4.5 g ai / ha or more, 4.6 g ai / ha or more, 4.7 g ai / ha or more, 4.8 g ai / ha or more, 4.9 g ai / ha or more, 5 g ai / ha or more, 5.2 g ai / ha or more, 5.4 g ai / ha or more, 5.6 g ai / ha or more, 5.8 g ai / ha or more, 6 g ai / ha or more, 6.2 g ai / ha or more, 6.4 g ai / ha or more, 6.6 g ai / ha or more, 6.8 g ai / ha or more, 7 g ai / ha or more, 7.2 g ai / ha or more, 7.4 g ai / ha or more, 7.6 g ai / ha or more, 7.8 g ai / ha or more, 8 g ai / ha or more, 8.2 g ai / ha or more, 8.4 g ai / ha or more, 8.6 g ai / ha or more, 8.8 g ai / ha or more, 9 g ai / ha or more, 9.2 g ai / ha or more, 9.4 g ai / ha or more, 9.6 g ai / ha or more, 9.8 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 16.2 g ai / ha or more, 16.4 g ai / ha or more, 16.6 g ai / ha or more, 16.8 g ai / ha or more, 17 g ai / ha or more, 17.1 g ai / ha or more, 17.2 g ai / ha or more, 17.3 g ai / ha or more, or 17.4 g ai / ha or more; in an amount of 17.5 g ai / ha or less, such as 17.4 g ai / ha or less, 17.3 g ai / ha or less, 17.2 g ai / ha or less, 17.1 g ai / ha or less, 17 g ai / ha or less, 16.8 g ai / ha or less, 16.6 g ai / ha or less, 16.4 g ai / ha or less, 16.2 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9.8 g ai / ha or less, 9.6 g ai / ha or less, 9.4 g ai / ha or less, 9.2 g ai / ha or less, 9 g ai / ha or less, 8.8 g ai / ha or less, 8.6 g ai / ha or less, 8.4 g ai / ha or less, 8.2 g ai / ha or less, 8 g ai / ha or less, 7.8 g ai / ha or less, 7.6 g ai / ha or less, 7.4 g ai / ha or less, 7.2 g ai / ha or less, 7 g ai / ha or less, 6.8 g ai / ha or less, 6.6 g ai / ha or less, 6.4 g ai / ha or less, 6.2 g ai / ha or less, 6 g ai / ha or less, 5.8 g ai / ha or less, 5.6 g ai / ha or less, 5.4 g ai / ha or less, 5.2 g ai / ha or less, 5 g ai / ha or less, 4.9 g ai / ha or less, 4.8 g ai / ha or less, 4.7 g ai / ha or less, 4.6 g ai / ha or less, 4.5 g ai / ha or less, or 4.4 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 4.4–17.5 g ai / ha, 4.5– 16 g ai / ha, 4.8–11 g ai / ha, 5–17.3 g ai / ha, 5–16.2 g ai / ha, 5.4–13 g ai / ha, 5.8–10 g ai / ha, 6–12 g ai / ha, 6–16 g ai / ha, 7.4–16.4 g ai / ha, 7.8–15 g ai / ha, 8–15 g ai / ha, or 8–17.1 g ai / ha. Tribenuron Compositions and methods of the present disclosure can include tribenuron or an agriculturally acceptable salt or ester thereof. Tribenuron-methyl, shown below, is a sulfonylurea that provides e.g., post-emergence control of broadleaf weeds in cereal crops, including wheat, barley, oats, rye and triticale. Tribenuron, as well as methods of preparing tribenuron, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. Tribenuron can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, tribenuron is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 3.75 g ai / ha or more, such as 4 g ai / ha or more, 4.25 g ai / ha or more, 4.5 g ai / ha or more, 4.75 g ai / ha or more, 5 g ai / ha or more, 5.25 g ai / ha or more, 5.5 g ai / ha or more, 5.75 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 7.5 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 11 g ai / ha or more, 12 g ai / ha or more, 13 g ai / ha or more, 14 g ai / ha or more, 15 g ai / ha or more, 16 g ai / ha or more, 17 g ai / ha or more, 18 g ai / ha or more, 19 g ai / ha or more, 20 g ai / ha or more, 21 g ai / ha or more, 22 g ai / ha or more, 23 g ai / ha or more, 24 g ai / ha or more, 25 g ai / ha or more, 25.5 g ai / ha or more, 26 g ai / ha or more, 26.5 g ai / ha or more, 27 g ai / ha or more, 27.5 g ai / ha or more, 28 g ai / ha or more, 28.5 g ai / ha or more, 29 g ai / ha or more, 29.25 g ai / ha or more, 29.5 g ai / ha or more, or 29.75 g ai / ha or more; in an amount of 30 g ai / ha or less, such as 29.75 g ai / ha or less, 29.5 g ai / ha or less, 29.25 g ai / ha or less, 29 g ai / ha or less, 28.5 g ai / ha or less, 28 g ai / ha or less, 27.5 g ai / ha or less, 27 g ai / ha or less, 26.5 g ai / ha or less, 26 g ai / ha or less, 25 g ai / ha or less, 24 g ai / ha or less, 23 g ai / ha or less, 22 g ai / ha or less, 21 g ai / ha or less, 20 g ai / ha or less, 19 g ai / ha or less, 18 g ai / ha or less, 17 g ai / ha or less, 16 g ai / ha or less, 15 g ai / ha or less, 14 g ai / ha or less, 13 g ai / ha or less, 12 g ai / ha or less, 11 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7.5 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5.75 g ai / ha or less, 5.5 g ai / ha or less, 5.25 g ai / ha or less, 5 g ai / ha or less, 4.75 g ai / ha or less, 4.5 g ai / ha or less, 4.25 g ai / ha or less, or 4 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above such as 3.75–30 g ai / ha, 4–27.5 g ai / ha, 4.25–23 g ai / ha, 4.5–17 g ai / ha, 5–25 g ai / ha, 6–29.5 g ai / ha, 7–28 g ai / ha, 7.5–23 g ai / ha, 7.5– 20 g ai / ha, 9–30 g ai / ha, 10–19 g ai / ha, or 10–27.5 g ai / ha. SYNTHETIC AUXIN HERBICIDES In addition to the compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), the compositions can include a synthetic auxin herbicide. Synthetic auxin herbicides mimic natural plant hormones and can inhibit cell division and growth. Synthetic auxin herbicides include phenoxy herbicides, benzoic acid herbicides, aryl picolinate herbicides, quinoline carboxylic acid herbicides, pyrimidine carboxylic acid herbicides, and benzothiazole herbicides, as well as agriculturally acceptable salts and esters thereof. In some aspects, the composition can include a synthetic auxin herbicide selected from the group consisting of 2,4-D; 2,4-DB; 2,3,6-TBA, aminocyclopyrachlor, aminopyralid, benazolin-ethyl, chloramben, clomeprop, clopyralid, dichlorprop, dichlorprop-P, dicamba, florpyrauxifen (such as florpyrauxifen-benzyl), fluchloraminopyr (e.g., fluchloraminopyr- tefuryl), fluroxypyr, fluroxypyr-MHE, halauxifen (such as halauxifen-methyl), indolauxipyr (such as indolauxipyr-cyanomethyl), mecoprop, mecoprop-P, MCPA, MCPA-thioethyl, MCPB, picloram, quinclorac, quinmerac, triclopyr, agriculturally acceptable salts and esters thereof, and combinations thereof. In some aspects, the synthetic auxin herbicide can comprise 2,4-D, MCPA, aminopyralid, clopyralid, dicamba, florpyrauxifen, fluroxypyr, halauxifen, quinclorac, agriculturally acceptable salts and esters thereof, and combinations thereof. The synthetic auxin herbicide or agriculturally acceptable salt or ester thereof can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, the synthetic auxin herbicide or agriculturally acceptable salt or ester thereof is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 gram acid equivalent per hectare (g ai) or more, such as 1.5 g ai or more, 2 g ai or more, 2.5 g ai or more, 3 g ai or more, 3.5 g ai or more, 4 g ai or more, 4.5 g ai or more, 5 g ai or more, 6 g ai or more, 7 g ai or more, 8 g ai or more, 9 g ai or more, 10 g ai or more, 15 g ai or more, 20 g ai or more, 25 g ai or more, 30 g ai or more, 35 g ai or more, 40 g ai or more, 45 g ai or more, 50 g ai or more, 55 g ai or more, 60 g ai or more, 65 g ai or more, 70 g ai or more, 75 g ai or more, 80 g ai or more, 85 g ai or more, 90 g ai or more, 95 g ai or more, 100 g ai or more, 110 g ai or more, 120 g ai or more, 130 g ai or more, 140 g ai or more, 150 g ai or more, 160 g ai or more, 170 g ai or more, 180 g ai or more, 190 g ai or more, 200 g ai or more, 220 g ai or more, 240 g ai or more, 250 g ai or more, 260 g ai or more, 280 g ai or more, 300 g ai or more, 320 g ai or more, 340 g ai or more, 350 g ai or more, 360 g ai or more, 380 g ai or more, 400 g ai or more, 450 g ai or more, 500 g ai or more, 550 g ai or more, 600 g ai or more, 650 g ai or more, 700 g ai or more, 750 g ai or more, 800 g ai or more, 850 g ai or more, 900 g ai or more, 950 g ai or more, 1000 g ai or more, 1050 g ai or more, 1100 g ai or more, 1150 g ai or more, 1200 g ai or more, 1250 g ai or more, 1300 g ai or more, 1350 g ai or more, 1400 g ai or more, 1450 g ai or more, 1500 g ai or more, 1600 g ai or more, 1700 g ai or more, 1800 g ai or more, 1900 g ai or more, 2000 g ai or more, 2050 g ai or more, 2100 g ai or more, 2150 g ai or more, 2200 g ai or more, 2240 g ai or more, 2250 g ai or more, 2300 g ai or more, 2350 g ai or more, 2400 g ai or more, 2450 g ai or more, 2500 g ai or more, 2600 g ai or more, 2700 g ai or more, 2750 g ai or more, 2800 g ai or more, 2900 g ai or more, 3000 g ai or more, 3050 g ai or more, 3100 g ai or more, 3150 g ai or more, 3200 g ai or more, 3250 g ai or more, 3300 g ai or more, 3350 g ai or more, 3400 g ai or more, 3450 g ai or more, 3500 g ai or more, 3600 g ai or more, 3700 g ai or more, 3750 g ai or more, 3800 g ai or more, 3900 g ai or more, or 3950 g ai or more; in an amount of 4000 g ai or less, such as 3950 g ai or less, 3900 g ai or less, 3800 g ai or less, 3750 g ai or less, 3700 g ai or less, 3600 g ai or less, 3500 g ai or less, 3450 g ai or less, 3400 g ai or less, 3350 g ai or less, 3300 g ai or less, 3250 g ai or less, 3200 g ai or less, 3150 g ai or less, 3100 g ai or less, 3050 g ai or less, 3000 g ai or less, 2900 g ai or less, 2800 g ai or less, 2750 g ai or less, 2700 g ai or less, 2600 g ai or less, 2500 g ai or less, 2450 g ai or less, 2400 g ai or less, 2350 g ai or less, 2300 g ai or less, 2250 g ai or less, 2240 g ai or less, 2200 g ai or less, 2150 g ai or less, 2100 g ai or less, 2050 g ai or less, 2000 g ai or less, 1900 g ai or less, 1800 g ai or less, 1750 g ai or less, 1700 g ai or less, 1600 g ai or less, 1500 g ai or less, 1450 g ai or less, 1400 g ai or less, 1350 g ai or less, 1300 g ai or less, 1250 g ai or less, 1240 g ai or less, 1200 g ai or less, 1150 g ai or less, 1100 g ai or less, 1050 g ai or less, 1000 g ai or less, 950 g ai or less, 900 g ai or less, 850 g ai or less, 800 g ai or less, 750 g ai or less, 700 g ai or less, 650 g ai or less, 600 g ai or less, 550 g ai or less, 500 g ai or less, 450 g ai or less, 400 g ai or less, 380 g ai or less, 360 g ai or less, 350 g ai or less, 340 g ai or less, 320 g ai or less, 300 g ai or less, 280 g ai or less, 260 g ai or less, 250 g ai or less, 240 g ai or less, 220 g ai or less, 200 g ai or less, 190 g ai or less, 180 g ai or less, 170 g ai or less, 160 g ai or less, 150 g ai or less, 140 g ai or less, 130 g ai or less, 120 g ai or less, 110 g ai or less, 100 g ai or less, 95 g ai or less, 90 g ai or less, 85 g ai or less, 80 g ai or less, 75 g ai or less, 70 g ai or less, 65 g ai or less, 60 g ai or less, 55 g ai or less, 50 g ai or less, 45 g ai or less, 40 g ai or less, 35 g ai or less, 30 g ai or less, 25 g ai or less, 20 g ai or less, 15 g ai or less, 10 g ai or less, 9 g ai or less, 8 g ai or less, 7 g ai or less, 6 g ai or less, 5 g ai or less, 4.5 g ai or less, 4 g ai or less, 3.5 g ai or less, 3 g ai or less, 2.5 g ai or less, 2 g ai or less, 1.5 g ai or less, or 1 g ai or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai, 1–2240 g ai, 1-150 g ai, 1.5–3150 g ai, 2–900 g ai, 2.5–3200 g ai, 3–1250 g ai, 5–260 g ai, 6– 750 g ai, 7–2100 g ai, 10–2240 g ai, 20–3600 g ai, 40–3950 g ai, 50–400 g ai, 70–1250 g ai, 100–1400 g ai, or 250–1700 g ai. PHENOXYCARBOXYLIC ACIDS In some aspects, the composition contains compounds according to Formula I or the compounds PYR-1 through PYR-21 (and all stereoisomers thereof), and (b) 2,4-D, 2,4- DB2, clomeprop, dichlorprop, mecoprop, MCPA, MCPB, or agriculturally acceptable salts or esters thereof. 2,4-D In some aspects, the synthetic auxin herbicide can comprise 2,4-D or an agriculturally acceptable salt or ester thereof. 2,4-D, shown below, is a phenoxycarboxylic acid herbicide that provides broad spectrum control of many annual, biannual and perennial broad-leaved weeds and aquatic broad-leaved weeds in cereals, maize, sorghum, grasslands, established turf, grass seed crops, orchards (pome fruit and stone fruit), cranberries, asparagus, sugar cane, rice, forestry, and on non-crop land (including areas adjacent to water). 2,4- D, as well as methods of preparing 2,4-D, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, 2,4-D can be provided as an agriculturally acceptable salt or ester of 2,4-D. Exemplary agriculturally acceptable salts and esters of 2,4-D include, but are not limited to, 2,4-D-ammonium 2,4-D-butotyl, 2,4-D-2-butoxypropyl, 2,4-D-3-butoxypropyl, 2,4-D-butyl, 2,4-D choline, 2,4-D-diethylammonium, 2,4-D-dimethylammonium (2,4-D DMA), 2,4-D-diolamine, 2,4-D-dodecylammonium, 2,4-D-ethyl, 2,4-D-2-ethylhexyl (2,4-D EHE), 2,4-D-heptylammonium, 2,4-D-isobutyl, 2,4-D-isoctyl, 2,4-D-isopropyl, 2,4-D- isopropylammonium, 2,4-D-lithium, 2,4-D-meptyl, 2,4-D-methyl, 2,4-D-octyl, 2,4-D-pentyl, 2,4-D-propyl, 2,4-D-sodium, 2,4-D-tefuryl, 2,4-D-tetradecylammonium, 2,4-D- triethylammonium, 2,4-D-tris(2-hydroxypropyl)ammonium, 2,4-D-trolamine, and clacyfos. In some aspects, the 2,4-D can be provided as 2,4-D-2-ethylhexyl (2,4-D EHE), shown below. In some aspects, 2,4-D can be provided as 2,4-D DMA, shown below. In some aspects, the 2,4-D can be provided as 2,4-D choline, shown below. In some aspects, the 2,4-D can be provided as 2,4-D triethanolamine (2,4-D- trolamine), shown below. Also included herein are analogs of 2,4-D, such as 2,4-D diamers, aminoxy, amides, and esters. Exemplary analogs of 2,4-D include the analogs disclosed in PCT / US2023 / 071586 filed on August 3, 2023, the disclosure of which is incorporated by reference in its entirety herein. Exemplary 2,4-D analogs include the following: TABLE 23: 2,4-D ANALOGS Exemplary uses of 2,4-D, such as 2,4-D-choline or 2,4-D trolamine may include, but are not limited to, controlling annual and perennial broadleaf weeds, including, but not limited to, glyphosate-resistant broadleaf weeds. 2,4-D-Choline can be used in crops that have been made tolerant to 2,4-D, including, but not limited to, 2,4-D-tolerant soybeans, maize, and cotton. 2,4-D-Choline is generally, but is not required to be, applied post-emergent. 2,4-D- Choline can also be used for weed control in non-crop and perennial cropping systems. 2,4-D can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, 2,4-D is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 gram active ingredient per hectare (g ai / ha) or more, such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250–1700 g ai / ha. 2,4-DB In some aspects, the synthetic auxin herbicide can comprise 2,4-DB is a phenoxycarboxylic acid herbicide that provides post-emergence control of many annual and perennial broadleaf weeds in alfalfa, clovers, cereals, grassland, forage, legumes, soybeans, and peanuts. 2,4-DB, as well as methods of making 2,4-DB, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, 2,4-DB can be provided as an agriculturally acceptable salt or ester of 2,4-DB. Exemplary agriculturally acceptable salts and esters of 2,4-DB include, but are not limited to, 2,4-DB-butyl, 2,4-DB-dimethylammonium (2,4-DB DMA), 2,4-DB-isoctyl, 2,4- DB-potassium, and 2,4-DB-sodium. 2,4-DB can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, 2,4-DB is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more, such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250–1700 g ai / ha. Clomeprop In some aspects, the synthetic auxin herbicide can comprise clomeprop or an agriculturally acceptable salt or ester thereof. Clomeprop, shown below, is a phenoxycarboxylic acid herbicide that provides pre- to early post-emergence control of broad- leaf and sedge weeds in paddy rice. Clomeprop, as well as methods of preparing clomeprop, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. Dichlorprop In some aspects, the synthetic auxin herbicide can comprise dichlorprop or an agriculturally acceptable salt or ester thereof. Dichlorprop, shown below, is a phenoxycarboxylic herbicide that provides broad-spectrum control of annual and perennial broad-leaved weeds in cereals and grasslands; brush control in non-crop land; control of broad- leaved aquatic weeds; and maintenance of embankments and roadside verges. Dichlorprop, as well as methods of making dichlorprop, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, dichlorprop can be provided as an agriculturally acceptable salt or ester of dichlorprop. Exemplary agriculturally acceptable salts and esters of dichlorprop include, but are not limited to, dichlorprop-butotyl, dichlorprop-dimethylammonium, dichlorprop-ethylammonium, dichlorprop-2-ethylhexyl, dichlorprop-isoctyl, dichlorprop- methyl, dichlorprop-potassium, dichlorprop-sodium, dichlorprop-P, dichlorprop-P- dimethylammonium, dichlorprop-P-2-ethylhexyl, dichlorprop-P-potassium, and dichlorprop- P-sodium. In some aspects, the dichlorprop can be provided as the stereoisomer dichlorprop- P, shown below. Dichlorprop can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, dichlorprop is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more, such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250– 1700 g ai / ha. Mecoprop In some aspects, the synthetic auxin herbicide can comprise mecoprop or an agriculturally acceptable salt or ester thereof. Mecoprop, shown below, is a phenoxy carboxylic acid herbicide that provides broad-spectrum control of broad-leaved weeds in wheat, barley, oats, herbage seed crops, grassland, and under fruit trees and vines. Mecoprop also provides control of docks (Rumex spp.) in meadows and pastures. Mecoprop, as well as methods of making mecoprop, are known in the art. Its herbicidal activity is described in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, mecoprop can be provided as an agriculturally acceptable salt or ester of mecoprop. Exemplary agriculturally acceptable salts and esters of mecoprop include, but are not limited to, mecoprop-butotyl, mecoprop-potassium, mecoprop-sodium, mecoprop- dimethylammonium, mecoprop-diolamine, mecoprop-ethadyl, mecoprop-2-ethylhexyl, mecoprop-isoctyl, mecoprop-methyl, mecoprop-trolamine, mecoprop-P, mecoprop-P-butotyl, mecoprop-P-dimethylammonium, mecoprop-P-ethylhexyl, and mecoprop-P-potassium. In some aspects, the mecoprop can be provided as the stereoisomer mecoprop-P, shown below. Mecoprop can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, mecoprop is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more, such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250– 1700 g ai / ha. MCPA In some aspects, the synthetic auxin herbicide can comprise MCPA or an agriculturally acceptable salt or ester thereof. MCPA, shown below, is a phenoxycarboxylic acid herbicide that provides broad-spectrum control of many annual, biannual, and perennial broad-leaved weeds, woody weeds, and aquatic broad-leaved weeds in cereals, herbage seed crops, flax, rice, vines, peas, potatoes, asparagus, grassland, turf, under fruit trees, forestry, and on roadside verges and embankments. MCPA, as well as methods of preparing MCPA, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, MCPA can be provided as an agriculturally acceptable salt or ester of MCPA. Exemplary agriculturally acceptable salts of MCPA include, but are not limited to, MCPA-butotyl, MCPA-butyl, MCPA-dimethylammonium (MCPA-DMA), MCPA- diolamine, MCPA-ethyl, MCPA-2-ethylhexyl (MCPA EHE), MCPA-isobutyl, MCPA-isoctyl, MCPA-isopropyl, MCPA-methyl, MCPA-olamine, MCPA-potassium, MCPA-sodium, MCPA-trolamine. In some aspects, the MCPA can be provided as MCPA-2-ethylhexyl (MCPA EHE), shown below. In some aspects, the MCPA can be provided as MCPA-dimethylammonium (MCPA-DMA), shown below. MCPA can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, MCPA is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250–1700 g ai / ha. MCPB In some aspects, the synthetic auxin herbicide can comprise MCPB or an agriculturally acceptable salt or ester thereof. MCPB, shown below, is a phenoxycarboxylic acid herbicide that provides broad-spectrum control of many broad-leaved weeds, woody weeds, and aquatic broad-leaved weeds in rice, cereals, clovers, sainfoin, peas, peanuts, grassland, turf, and forestry. MCPB, as well as methods of preparing MCPB, are known in the art. Its herbicidal activity is described, for example, in The Pesticide Manual, Seventeenth Edition, 2016. In some aspects, MCPB can be provided as an agriculturally acceptable salt or ester of MCPB. Exemplary agriculturally acceptable salts of MCPB include, but are not limited to, MCPB-ethyl, MCPB-potassium, and MCPB-sodium. MCPB can be applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount sufficient to induce a herbicidal effect. In some aspects, MCPB is applied to vegetation or an area adjacent the vegetation or applied to soil or water to prevent the emergence or growth of vegetation in an amount of 1 g ai / ha or more, such as 2 g ai / ha or more, 3 g ai / ha or more, 4 g ai / ha or more, 5 g ai / ha or more, 6 g ai / ha or more, 7 g ai / ha or more, 8 g ai / ha or more, 9 g ai / ha or more, 10 g ai / ha or more, 15 g ai / ha or more, 20 g ai / ha or more, 25 g ai / ha or more, 30 g ai / ha or more, 35 g ai / ha or more, 40 g ai / ha or more, 45 g ai / ha or more, 50 g ai / ha or more, 60 g ai / ha or more, 70 g ai / ha or more, 75 g ai / ha or more, 80 g ai / ha or more, 90 g ai / ha or more, 100 g ai / ha or more, 125 g ai / ha or more, 150 g ai / ha or more, 175 g ai / ha or more, 200 g ai / ha or more, 225 g ai / ha or more, 250 g ai / ha or more, 275 g ai / ha or more, 300 g ai / ha or more, 325 g ai / ha or more, 350 g ai / ha or more, 375 g ai / ha or more, 400 g ai / ha or more, 450 g ai / ha or more, 500 g ai / ha or more, 550 g ai / ha or more, 600 g ai / ha or more, 650 g ai / ha or more, 700 g ai / ha or more, 750 g ai / ha or more, 800 g ai / ha or more, 850 g ai / ha or more, 900 g ai / ha or more, 950 g ai / ha or more, 1000 g ai / ha or more, 1100 g ai / ha or more, 1200 g ai / ha or more, 1300 g ai / ha or more, 1400 g ai / ha or more, 1500 g ai / ha or more, 1600 g ai / ha or more, 1700 g ai / ha or more, 1800 g ai / ha or more, 1900 g ai / ha or more, 2000 g ai / ha or more, 2100 g ai / ha or more, 2200 g ai / ha or more, 2240 g ai / ha or more, 2250 g ai / ha or more, 2300 g ai / ha or more, 2400 g ai / ha or more, 2500 g ai / ha or more, 2600 g ai / ha or more, 2700 g ai / ha or more, 2800 g ai / ha or more, 2900 g ai / ha or more, 3000 g ai / ha or more, 3100 g ai / ha or more, 3200 g ai / ha or more, 3300 g ai / ha or more, 3400 g ai / ha or more, 3500 g ai / ha or more, 3600 g ai / ha or more, 3700 g ai / ha or more, 3750 g ai / ha or more, 3800 g ai / ha or more, 3850 g ai / ha or more, 3900 g ai / ha or more, or 3950 g ai / ha or more; in an amount of 4000 g ai / ha or less, such as 3950 g ai / ha or less, 3900 g ai / ha or less, 3850 g ai / ha or less, 3800 g ai / ha or less, 3750 g ai / ha or less, 3700 g ai / ha or less, 3600 g ai / ha or less, 3500 g ai / ha or less, 3400 g ai / ha or less, 3300 g ai / ha or less, 3200 g ai / ha or less, 3100 g ai / ha or less, 3000 g ai / ha or less, 2900 g ai / ha or less, 2800 g ai / ha or less, 2700 g ai / ha or less, 2600 g ai / ha or less, 2500 g ai / ha or less, 2400 g ai / ha or less, 2300 g ai / ha or less, 2250 g ai / ha or less, 2240 g ai / ha or less, 2200 g ai / ha or less, 2100 g ai / ha or less, 2000 g ai / ha or less, 1900 g ai / ha or less, 1800 g ai / ha or less, 1700 g ai / ha or less, 1600 g ai / ha or less, 1500 g ai / ha or less, 1400 g ai / ha or less, 1300 g ai / ha or less, 1200 g ai / ha or less, 1100 g ai / ha or less, 1000 g ai / ha or less, 950 g ai / ha or less, 900 g ai / ha or less, 850 g ai / ha or less, 800 g ai / ha or less, 750 g ai / ha or less, 700 g ai / ha or less, 650 g ai / ha or less, 600 g ai / ha or less, 550 g ai / ha or less, 500 g ai / ha or less, 450 g ai / ha or less, 400 g ai / ha or less, 375 g ai / ha or less, 350 g ai / ha or less, 325 g ai / ha or less, 300 g ai / ha or less, 275 g ai / ha or less, 250 g ai / ha or less, 225 g ai / ha or less, 200 g ai / ha or less, 175 g ai / ha or less, 150 g ai / ha or less, 125 g ai / ha or less, 100 g ai / ha or less, 90 g ai / ha or less, 80 g ai / ha or less, 75 g ai / ha or less, 70 g ai / ha or less, 60 g ai / ha or less, 50 g ai / ha or less, 45 g ai / ha or less, 40 g ai / ha or less, 35 g ai / ha or less, 30 g ai / ha or less, 25 g ai / ha or less, 20 g ai / ha or less, 15 g ai / ha or less, 10 g ai / ha or less, 9 g ai / ha or less, 8 g ai / ha or less, 7 g ai / ha or less, 6 g ai / ha or less, 5 g ai / ha or less, 4 g ai / ha or less, 3 g ai / ha or less, or 2 g ai / ha or less; or in an amount ranging from any of the minimum values described above to any of the maximum values described above, such as 1–4000 g ai / ha, 1-150 g ai / ha, 2–3100 g ai / ha, 2–900 g ai / ha, 3–2600 g ai / ha, 3–1200 g ai / ha, 5–275 g ai / ha, 6–750 g ai / ha, 7–2100 g ai / ha, 10–2240 g ai / ha, 20–3300 g ai / ha, 40–3950 g ai / ha, 50–400 g ai / ha, 70–2400 g ai / ha, 100–950 g ai / ha, or 250–1700 g ai / ha. BENZOIC ACIDS In some a...

Claims

WHAT IS CLAIMED IS:

1. A molecule comprising the structure of Formula (I):Formula (I) wherein: X is selected from the group consisting of O and S; Y is selected from the group consisting of O, NR5, and S; R1is selected from H or F; R2is selected from methyl or cyclopropyl; R3is selected from H, methyl, or methoxy; and R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl;R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; R78and R79together form a substituted or unsubstituted ring; and R5is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C16)-alkenyl, (C3- C16)-alkynyl, (C1-C10)-alkyl-aryl, (C1-C10)-alkoxy, (C3-C10)-alkenyloxy, (C3-C10)-alkynyloxy, aryl-(C1-C10)-alkoxy, heterocyclyl-alkoxy, hydroxy, (C1-C10)-alkyl-sulfonyl, (C3-C8)- cycloalkyl-sulfonyl, (C3-C8)-cycloalkyl-(C1-C10)-alkyl-sulfonyl, aryl-sulfonyl, heteroaryl- sulfonyl, R72R73N-sulfonyl, (C1-C10)-alkoxy-NR74-sulfonyl, and aryl-oxy-sulfonyl; or an N-oxide or agriculturally acceptable salt thereof.

2. The molecule of claim 1 comprising the structure of Formula (II):wherein: R1is selected from the group consisting of H and F; R2is selected from the group consisting of methyl and cyclopropyl; R3is selected from the group consisting of H, methyl, and methoxy; and R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl;Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring, or an N-oxide or agriculturally acceptable salt thereof.

3. The molecule of claim 1 or claim 2, wherein the molecule is chosen from Formula (V), Formula (VI), Formula (VII), or Formula (Formula (V) Formula (VI) Formula (VII) Formula (VIII) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl;Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring, or an N-oxide or agriculturally acceptable salt thereof.

4. The molecule of any one of claims 1-3, wherein the molecule is chosen from Compound A, Compound B, Compound C, or Compound D:Compound A Compound B Compound C Compound D.

5. The molecule of any one of claims 1-3, wherein the molecule is chosen from Compound E, Compound F, Compound G, or Compound H:

6. The molecule of claim 1, comprising the structure of Formula (III):Formula (III), wherein R1is selected from the group consisting of H and F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71; R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring, or an N-oxide or agriculturally acceptable salt thereof.

7. The molecule of claim 1 or claim 6, wherein the molecule is chosen from Formula (IX), or Formula (X):Formula (IX) Formula (X) wherein R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)- cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl- heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)- alkyl, (C1-C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1- C10)-alkyl-C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)- alkyl-C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, R70, R71, R72, R73, R74,and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring, or an N-oxide or agriculturally acceptable salt thereof.

8. The molecule of any one of claims 1, 6, or 7, wherein the molecule is chosen from Compound I, Compound J, Compound K, or Compound L:

9. The molecule of claim 1, comprising the structure of Formula (IV):Formula (IV) wherein: R1is selected from the group consisting of H and F; R4is selected from the group consisting of H, (C1-C16)-alkyl, (C3-C10)-cycloalkyl, (C3-C16)-alkenyl, (C3-C16)-alkynyl, (C1-C10)-alkyl-aryl, aryl, (C1-C10)-alkyl-heteroaryl, heteroaryl, (C1-C10)-alkyl-cyano, (C1-C16)-haloalkyl, (C1-C10)-alkoxy-(C1-C10)-alkyl, (C1- C10)-alkylthio-(C1-C10)-alkyl, (C1-C10)-alkyl-sulfonyl-(C1-C10)-alkyl, R72R73N, SiR75R76R77, (C1-C10)-alkyl-SiR75R76R77, R78R79C=N, (C1-C10)-alkyl-C(=O)QR70, aryl-(C1-C10)-alkyl- C(=O)QR70, heteroaryl-(C1-C10)-alkyl-C(=O)QR70, (C3-C10)-cycloalkyl-(C1-C10)-alkyl- C(=O)QR70, R70QC(=O)-(C1-C10)-alkyl-C(=O)QR71, R70QC(=O)Q-(C1-C10)-alkyl- C(=O)QR71, hydroxy-(C1-C10)-alkyl-C(=O)QR70, (C1-C10)-alkylthio-(C1-C10)-alkyl- C(=O)QR70, and (R80O)2P(=O)-(C1-C10)-alkyl; Q is selected from the group consisting of O, S, and NR71, X is selected from the group consisting of O and S,R70, R71, R72, R73, R74, and R80are independently selected from the group consisting of H, (C1-C16)-alkyl, aryl, heteroaryl, (C1-C16)-alkyl-aryl, and (C1-C16)-haloalkyl; R72and R73together form a substituted or unsubstituted ring; R75, R76, and R77are independently selected from the group consisting of (C1-C16)- alkyl and aryl; R78and R79are independently selected from the group consisting of (C1-C16)-alkyl, (C1-C16)-alkyl-aryl, (C1-C16)-haloalkyl, aryl, and heteroaryl; and R78and R79together form a substituted or unsubstituted ring, or an N-oxide or agriculturally acceptable salt thereof.

10. The molecule of claim 1 or claim 9, wherein the molecule is selected from the group consisting of Compound M, Compound N, and Compound O:

11. The molecule of claim 1, wherein the molecule is selected from the group consisting of Compound P and Compound U:

12. A composition comprising a molecule from any one of claims 1-11, further comprising at least one additive.

13. The composition of claim 12, wherein the additive is selected from the group consisting of adjuvants, safeners, carriers, and combinations thereof.

14. A composition comprising: a first herbicide (a), wherein the first herbicide is a molecule from any one of claims 1-11; and a second herbicide (b), wherein (b) is selected from the group consisting of acetolactate synthase (ALS) inhibitors, acetohydroxy acid synthase (AHAS) inhibitors, photosystem II (PS-II) inhibitors, acetyl CoA carboxylase (ACCase) inhibitors, synthetic auxins, auxin transport inhibitors, photosystem I inhibitors, 5-enolpyruvylshikimate-3- phosphate (EPSP) synthase inhibitors, glutamine synthetase inhibitors, microtubule assembly inhibitors, mitosis inhibitors, very long chain fatty acid (VLCFA) inhibitors, fatty acid and lipid synthesis (FA / LSI) inhibitors, protoporphyrinogen oxidase (PPO) inhibitors, carotenoid biosynthesis inhibitors, phytoene desaturase (PDS) inhibitors, 4-hydroxyphenyl-pyruvate- dioxygenase (HPPD) inhibitors, cellulose biosynthesis inhibitors, herbicides with multiple modes-of-action, and unclassified herbicides.

15. The composition of claim 14, wherein the second herbicide (b) is a PPO inhibitor herbicide selected from the group consisting of acifluorfen, azafenidin, benzfendizone, bifenox, butafenacil, carfentrazone, chlomethoxyfen, cinidon, fluazolate, flufenpyr, flumiclorac, flumioxazin, fluoroglycofen, fluthiacet, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen, saflufenacil, sulfentrazone, thidiazimin, tiafenacil, trifludimoxazin, agriculturally acceptable salts thereof, or combinations thereof.

16. The composition of claim 14, wherein the second herbicide (b) is an HPPD inhibitor herbicide selected from the group consisting of benzobicyclon, benzofenap, bicyclopyrone, fenquinotrione, isoxachlortole, isoxaflutole, lancotrione, mesotrione, pyraquinate, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, tolpyralate, topramezone, or an agriculturally acceptable salt or ester thereof, and combinations thereof.

17. The composition of claim 14, wherein the second herbicide (b) is a synthetic auxin herbicide or an auxin transport inhibitor herbicide selected from the group consisting 2,4-D; 2,4-DB; 2,3,6-TBA, aminocyclopyrachlor, aminopyralid, benazolin-ethyl, chloramben,clomeprop, clopyralid, dichlorprop, dichlorprop-P, dicamba, florpyrauxifen, florpyrauxifen- benzyl, fluchloraminopyr, fluroxypyr, fluroxypyr-MHE, halauxifen, halauxifen-methyl indolauxipyr, indolauxipyr-cyanomethyl, mecoprop, mecoprop-P, MCPA, MCPA-thioethyl, MCPB, picloram, quinclorac, quinmerac, triclopyr, agriculturally acceptable salts and esters thereof, and combinations thereof.

18. The composition of claim 17, wherein the auxin herbicide is 2,4-D or agriculturally acceptable salts and esters thereof.

19. The composition of claim 18, wherein the 2,4-D is 2,4-D choline.

20. The composition of claim 18, wherein the 2,4-D is 2,4-D trolamine.

21. The composition of claim 18, wherein the 2,4-D is selected from the group consisting22. The composition of claim 14, wherein the second herbicide (b) is glyphosate or an agriculturally acceptable salt or ester thereof.

23. The composition of claim 14, wherein the second herbicide (b) is a glutamine synthetase inhibitor herbicide.

24. The composition of claim 23, wherein the glutamine synthetase inhibitor herbicide is glufosinate or an agriculturally acceptable salt or ester thereof.

25. The composition of claim 14, wherein the second herbicide (b) is an ALS inhibitor herbicide selected from the group consisting of amidosulfuron, azimsulfuron, bispyribac,bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cloransulam, cyclosulfamuron, diclosulam, ethametsulfuron, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone, flucetosulfuron, flumetsulam, flupyrsulfuron, foramsulfuron, halosulfuron, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, iodosulfuron, iofensulfuron, mesosulfuron, metazosulfuron, metosulam, metsulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, penoxsulam, primisulfuron, propoxycarbazone, propyrisulfuron, prosulfuron, pyrazosulfuron, pyribenzoxim, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, pyroxsulam, rimsulfuron, sulfometuron, sulfosulfuron, thiencarbazone, thifensulfuron, triasulfuron, tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, and agriculturally acceptable salts and esters thereof.

26. The composition of claim 14, wherein the second herbicide (b) is a PS II inhibitor herbicide selected from the group consisting of ametryne, amicarbazone, atrazine, bentazone, bromacil, bromofenoxim, bromoxynil, chlorbromuron, chloridazon, chlorotoluron, chloroxuron, cyanazine, desmedipham, desmetryn, dimefuron, dimethametryn, diuron, ethidimuron, ethiozin, fenuron, fluometuron, hexazinone, iodobonil, ioxynil, isocil, isomethiozin, isoproturon, isouron, karbutilate, lenacil, linuron, metamitron, methabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron, neburon, pentanochlor, phenmedipham, prometon, prometryn, propanil, propazine, pyridafol, pyridate, siduron, simazine, simetryne, tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutryn, trietazine, and combinations thereof.

27. The composition of claim 14, wherein the second herbicide (b) is an ACCase inhibitor herbicide selected from the group consisting of alloxydim, butroxydim, clethodim, clodinafop, cloproxydim, cycloxydim, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop, pinoxaden, profoxydim, propaquizafop, quizalofop, sethoxydim, tepraloxydim, tralkoxydim, and agriculturally acceptable salts and esters thereof.

28. The composition of claim 14, wherein the second herbicide (b) is a VLCFA synthesis inhibitor herbicide selected from the group consisting of acetochlor, alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid, diphenamid, fentrazamide, flufenacet, ipfencarbazone, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, pethoxamid, piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, thenylchlor, and agriculturally acceptable salts and esters thereof.

29. The composition of claim 14, wherein the second herbicide (b) is a FA / LSI inhibitor herbicide selected from the group consisting of benfuresate, bensulide, butylate, cycloate, dalapon, EPTC, esprocarb, ethofumesate, flupropanate, molinate, orbencarb, prosulfocarb, thiobencarb, tiocarbazil, tri-allate, vernolate, and agriculturally acceptable salts or esters thereof.

30. The composition of claim 14, wherein the second herbicide (b) is a PDS inhibitor herbicide selected from the group consisting of beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone, norflurazon, picolinafen, and agriculturally acceptable salts and esters thereof.

31. The composition of claim 14, wherein the second herbicide (b) is photosystem I inhibitor selected from the group consisting of paraquat and diquat.

32. The composition of any one of claims 14-31, wherein the ratio of (a) to (b) is from 30:1 to 1:

30.

33. The composition of any one of the claims 14-31, wherein the ratio of (a) to (b) is from 20:1 to 1:

20.

34. The composition of any one of the claims 14-31, wherein the ratio of (a) to (b) is from 7:1 to 1:

7.

35. The composition of any one of the claims 14-31, wherein the ratio of (a) to (b) is from 5:1 to 1:

1.

36. The composition of any one of the claims 14-31, wherein the ratio of (a) to (b) is from 10:1 to 1:

10.

37. The composition of any one of claims 14-36, further comprising at least one additive selected from the group consisting of adjuvants, safeners, carriers, and combinations thereof.

38. The composition of claim 37, wherein the at least one additive is a safener.

39. The composition of claim 38, wherein the safener is an azole safener.

40. The composition of claim 38, wherein the safener is cloquintocet or an agriculturally ester or salt thereof.

41. The composition of claim 40, wherein the safener is cloquintocet-mexyl.

42. The composition of claim 38, wherein the safener is benoxacor, benthiocarb, brassinolide, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, disulfoton, fenchlorazole, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, harpin proteins, isoxadifen-ethyl, jiecaowan, jiecaoxi, mefenpyr, mefenpyr-diethyl, mephenate, naphthalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3- oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro [4.5]-decane, oxabetrinil, and N-phenyl- sulfonylbenzoic acid amides, or agriculturally acceptable salts thereof.

43. The composition of any one of claims 12-42, wherein the composition is in the form of an aqueous solution, an aqueous suspension, an aqueous dispersion, an aqueous emulsion, an aqueous microemulsion, an aqueous suspo-emulsion, an oil solution, an oil suspension, an oil dispersion, an oil emulsion, an oil microemulsion, an oil suspo-emulsion, a self- emulsifying formulation, a gel, a paste, a powder, a dust, a granular formulation, a material for spreading, or combinations thereof.

44. A method of controlling unwanted vegetation comprising applying the molecule of any one of claims 1-11 or the composition of any one of claims 12-43 to unwanted vegetation.

45. The method of claim 44, wherein the molecule or composition is applied to the unwanted vegetation or an area adjacent the unwanted vegetation or applied to soil or water around the unwanted vegetation by spraying, atomizing, dusting, sprinkling, spreading, or direct application of the molecule or composition.

46. The method of claim 44 or claim 45 wherein the molecule or composition is applied in crop plants that are resistant to herbicides, insecticides, fungicides, pathogens, insects, or combinations thereof.

47. The method of any one of claims 44-46, wherein the molecule or composition is applied to control undesirable vegetation comprising grasses, broadleaf weeds, sedge weeds, and combinations thereof.

48. The method of claims 44-47, wherein the molecule, molecule in the composition, or composition is applied in a range of 50 g ai / ha to 1,500 g ai / ha.

49. The method of claim 48, wherein the molecule, molecule in the composition, or composition is applied in a range of 80 g ai / ha to 1,200 g ai / ha.

50. A composition comprising: a first herbicide (a), selected from the compounds consisting of PYR-1, PYR-2, PYR- 3, PYR-4, PYR-5, PYR-6, PYR-7, PYR-8, PYR-9, PYR-10, PYR-11, PYR-12, PYR-13, PYR-14, PYR-15, PYR-16, PYR-17, PYR-18, PYR-19, PYR-20, and PYR-21:, , , , ,a second herbicide (b), wherein (b) is selected from the group consisting of acetolactate synthase (ALS), acetohydroxy acid synthase (AHAS) inhibitors, photosystem II (PS-II) inhibitors, acetyl CoA carboxylase (ACCase) inhibitors, synthetic auxins, auxin transport inhibitors, photosystem I inhibitors, 5- enolpyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, glutamine synthetase inhibitors, microtubule assembly inhibitors, mitosis inhibitors, very long chain fatty acid (VLCFA) inhibitors, fatty acid and lipid synthesis (FA / LSI) inhibitors, protoporphyrinogen oxidase (PPO) inhibitors, carotenoid biosynthesis inhibitors, phytoene desaturase (PDS) inhibitors, 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors, cellulose biosynthesis inhibitors, herbicides with multiple modes-of-action, and unclassified herbicides, wherein the ratio of (a) to (b) is from 30:1 to 1:

30.

51. The composition of claim 50, wherein (b) is an ACCase inhibitor.

52. The composition of claim 51, wherein the ACCase inhibitor is a cyclohexanedione.

53. The composition of claim 52, wherein the cyclohexanedione is clethodim.

54. The composition of claim 51, wherein the ACCase inhibitor is selected from the group consisting of clodinafop, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop, propaquizafop, quizalofop, pinoxaden, and agriculturally acceptable salts or esters thereof, or combinations thereof.

55. The composition of any one of claims 51-54, wherein the ratio of (a) to (b) is from 15:1 to 1:

15.

56. The composition of any one of claims 51-54, wherein the ratio of (a) to (b) is from 5:1 to 1:

15.

57. The composition of claim 50, wherein (b) is an ALS inhibitor.

58. The composition of claim 57, wherein the ALS inhibitor is selected from the group consisting of florasulam, cloransulam, diclosulam, flumetsulam, metosulam, penoxsulam, or pyroxsulam, and agriculturally acceptable salts or esters thereof.

59. The composition of claim 57, wherein the ALS inhibitor is a sulfonylurea.

60. The composition of claim 57, wherein the ALS inhibitor is a triazolopyrimidine.

61. The composition of claim 60, wherein the triazolopyrimidine is a type 1 triazolopyrimidine.

62. The composition of any one of claims 50 and 57-61, wherein the ratio of (a) to (b) is from 30:1 to 1:

20.

63. The composition of any one of claims 50 and 57-61, wherein the ratio of (a) to (b) is from 25:1 to 1:

1.

64. The composition of any one of claims 50 and 57-61, wherein the ratio of (a) to (b) is from 20:1 to 5:

1.

65. The composition of claim 50, wherein (b) is an auxin herbicide.

66. The composition of claim 65, wherein the auxin is a phenoxycarboxylic acid.

67. The composition of claim 66, wherein the phenoxycarboxylic acid is 2,4-D or agriculturally acceptable salts and esters thereof.

68. The composition of claim 67, wherein the 2,4-D is 2,4-D choline.

69. The composition of claim 67, wherein the 2,4-D is 2,4-D trolamine.

70. The composition of claim 67, wherein the 2,4-D is selected from the group consisting71. The composition of claim 65, wherein the auxin is a benzoic acid.

72. The composition of claim 71, wherein the benzoic acid is dicamba and agriculturally acceptable salt and esters thereof.

73. The composition of claim 65, wherein the auxin is a pyridine carboxylate.

74. The composition of claim 65, wherein the auxin is selected from the group consisting of aminopyralid, halauxifen, clopyralid, picloram, florpyrauxifen, indolauxipyr, and agriculturally acceptable salts and esters thereof.

75. The composition of claim 65, wherein the auxin is selected from the group consisting of 2,4-D, 2,4-DB, 2,3,6-TBA, aminocyclopyrachlor, aminopyralid, benazolin-ethyl, chloramben, clomeprop, clopyralid, dichlorprop, dichlorprop-P, dicamba, florpyrauxifen, florpyrauxifen-benzyl, fluchloraminopyr, fluchloraminopyr-tefuryl, fluroxypyr, fluroxypyr- MHE, halauxifen, halauxifen-methyl, indolauxipyr, indolauxipyr-cyanomethyl, mecoprop, mecoprop-P, MCPA, MCPA-thioethyl, MCPB, picloram, quinclorac, quinmerac, triclopyr, and agriculturally acceptable salts and esters thereof.

76. The composition of any one of claims 50 and 65-75, wherein the ratio of (a) to (b) is from 7:100 to 1:

5.

77. The composition of any one of claims 50 and 65-75, wherein the ratio of (a) to (b) is from 7:100 to 1:1.

78. The composition of any one of claims 50 and 65-75, wherein the ratio of (a) to (b) is from 7:100 to 5:

1.

79. The composition of any one of claims 50-78, further comprising a safener.

80. The composition of claim 79, wherein the safener is cloquintocet or an agriculturally ester or salt thereof.

81. The composition of claim 80, wherein the safener is cloquintocet-mexyl.

82. The composition of claim 79, wherein the safener is benoxacor, benthiocarb, brassinolide, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, disulfoton, fenchlorazole, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, harpin proteins, isoxadifen-ethyl, jiecaowan, jiecaoxi, mefenpyr, mefenpyr-diethyl, mephenate, naphthalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3- oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro [4.5]-decane, oxabetrinil, and N-phenyl- sulfonylbenzoic acid amides, or agriculturally acceptable salts thereof.

83. The composition of claim 79, wherein the safener is an azole safener.

84. A method of controlling unwanted vegetation comprising applying the composition of any one of claims 50-83 to unwanted vegetation.

85. The method of claim 84, wherein the composition is applied to the unwanted vegetation or an area adjacent the unwanted vegetation or applied to soil or water around the unwanted vegetation by spraying, atomizing, dusting, sprinkling, spreading, or direct application of the molecule or composition.

86. The method of claim 84 or claim 85 wherein the composition is applied in crop plants that are resistant to herbicides, insecticides, fungicides, pathogens, insects, or combinations thereof.

87. The method of any one of claims 84-86, wherein the composition is applied to control undesirable vegetation comprising grasses, broadleaf weeds, sedge weeds, and combinations thereof.

88. The method of claims 86-87, wherein the composition is applied in a range of 50 g ai / ha to 1,500 g ai / ha.

89. The method of claim 88, wherein the composition is applied in a range of 80 g ai / ha to 1,200 g ai / ha.

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