Peptide with antimicrobial activity

Abstract

The invention refers to a peptide with antimicrobial activity comprising the following sequence Y1-[R1-X1-R2-X2-R3-dL-dF-[2]Abz-dA-R3-X2-R2-X1-R1]-Y2 Wherein R1, R2, R3 are independently from each other D-or L- Arginine or an Arginine analogue, dL is D-Leucine, dF is D-Phenylalanine, [2]Abz is 2-Aminobenzoic acid, dA is D- Alanine, X1 is FaHbC (FcHdC)n -CH2-CHNH2CO2H, wherein a is 0,1, 2, 3; b is 0, 1, 2, 3; wherein the sum of a and b is always 3; c is 0, 1, 2; d is 0, 1, 2; wherein the sum of c and d is always 2; Wherein n is 0-5, X1 is Valine when at least one of R1, R2, R3 is D-Arginine; X2 is L- Tryptophan (W), D-Tryptophan or a Tryptophan analogue or X1, Y1 is Acetyl or H or any suitable protective group; and Y2 is NH2 or OH or any suitable protective group.

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