Artificial secoviridae satellite rnas

EP4705472A1Pending Publication Date: 2026-03-11FLAGSHIP PIONEERING INNOVATIONS VII LLC
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-05-03
Publication Date
2026-03-11

AI Technical Summary

Technical Problem

There is a need in agricultural applications to modify polynucleotides for improving phenotypes and genotypes of organisms, particularly for crop plants, where existing technologies have limitations in effectively utilizing Secoviridae RNA viruses for genetic modification.

Method used

The development of recombinant RNA molecules comprising a 5' RNA replication element, a cargo RNA molecule, and a 3' RNA replication element, operably linked, which are recognized by a Secoviridae RNA-dependent RNA polymerase, allowing for the creation of synthetic Secoviridae satellite RNAs that can be introduced into plants to induce phenotypic changes and be self-replicating, using various components such as viral capsid proteins and RNA-binding proteins.

Benefits of technology

This approach enables the modification of plant phenotypes and genotypes by introducing recombinant Secoviridae satellite RNAs that are self-replicating and can induce specific changes, enhancing agricultural traits such as resistance to pathogens and pests, while being recognized by specific RNA-dependent RNA polymerases.

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Abstract

Synthetic Secoviridae satellite RNA molecules and satellite particles containing the same are disclosed. Synthetic Secoviridae satellite RNA molecules which contain internal heterologous RNA virus (HRV) amplicons are also disclosed. Also disclosed are methods of using the Secoviridae satellite RNA molecules and satellite particles containing the same to change plant phenotypes, improve plant stress resistance, and improve plant pest and pathogen resistance.
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