B. burgdorferi peptidoglycan antibodies and uses thereof

Abstract

Described herein are compositions, assays, techniques, methods, for treating and / or detecting a Borrelia burgdorferi microorganism, the causative agent of Lyme disease.

Description

[0001]. - caonos. aca,on, caems oneaene, o, anroro..rovsonaaen reerenceerenns enre. e conens o wcsncororae ene “s- aca_on co.nxman”s, c are saeeuen ocneasn,e,n eecroncorm as an xme econen oe seuencesnsncororaeerennsaennreavn a sze o, es.^^.urorer, ceom suoneecn msaeerero,s ocrosreouceerenesreeronmer.areceo anoesaare. umans an anemaaso.eonrc examorree,aeo srreroacauereso are caae o causn sncanseasen cases omesease eacearne.. aone.rers esmaeo cause morean, e acue saeen caracerze ‘u-e’ s.urorer causes a-ascnecon w saenecona cannvove mue oran ssmemoms, wcsoowe a severeae- aa.eresnown aou wa causese cncsa an cause severe mor an cane reevan assasoesornecon,arcuar acv smoms anere areew cnca ormrovesease caracerzaon an unenecon.s suceres a crca nee uroreror assessmen an manaemen oeersnann anor meos oeecn. aon orencaon o anocumenencons a an recsauonns nome asease. suc aocumens avaae asror aroeresennvenon.^ ^ ^n a ^mssona ^ ereo caane so ome s aesceccas,enecnn aueosrreesacereeeorenca rneaeo an ano orramen ereo, wenre sonmee asoercres,aeeeecnouecsanessc areorreren re.aeo an ano orramen arn,orreaaonca,orrea anerson,orreaeassuer,oroerrr,eaor srencaa, azeor,orrea orreaanu,orrea vaasana,orreausa reaur, or aorreaone nae,orrea seman,orrea mamoo, ereo, wenre snomsea e ar ase necos,o orec rea acn. mnuesescreeren reaeo an ano orramen eorreaeeo enereos caae onna acan comonen on aorr can, oona acc-cc-anurc, an aa-rnnae orreaee muareoeeeonccuan,nc aamma-rnnaen aorreaeeocan, or a n some asecs,enuurc. ereo, werene ano orecrnamueensesecrreoenceruenes re onaee oor a mnor aenooe orramenneenenavn a seuenceas- ercenencao o es eac -. ne or more o : ereo, wenre snomee a asnecos,se aecnuesescreeren reaeo an ano orramen n some cmerc ano, auman ano, or aumanze ano. ereo, werene a asnecos, oerreacmnenuesereesocrnecueesre ana re,aeo an ano orramen canvscv, or comnaonsere aa', aa', av, a sne ereo, wenre snomee a ansecos, oreraecmno enu.esereeoscrs seeren reaeo an ano orramen an , an , an , a vara eeceromerou conssn o: an , n some asecs,eencereo, an an comnaonereo. ereo, w nuesescreeren reaeo an ano orramenmmunoconerene ano orramenereosneo an aen,ereormn an ereo, wenu re sa nome.ee a asnecos, orereacmnenuesereeoscrse a moenroecno rneaa aenoo an a onrraome onrraeremoe.n ^ ereo, wenre snomee a msoencocs,onae aencnouess seeseccreeromeren r-e,aeo, an an, oor or.ramen e anon o sromraem asenecse,reoe oecneuesescreeren reaeo aonuceoe encon n some ase resenscosure. e ano orramencse,reoe oecneureessenescrsceosureer,e wn reereaneoe aoonuncuceoeoeen ecnucon consss o a seuenceas- ercenencao an one o s:- es or onuceone s eonmceo anseces, aneoec onrruaesmenescrereeo oerene rreesaeenosc ao vseucorn.cun a n some asecs,eecnuesescreeren reaeo a ce orore. ancuesa an ano orramenereo oeresensco uaonereo encone ano orramenereo oeresensc sure, aonuceoe scosure, or an comnaon oa osure,c a vecor oeresen ancuesn saom aen a asnecos,e orecranmeune-sceesrceroe oereenre reseaneos acarmaceucaormuaon encone ano orramenereo oeresens osure, aonuceoe scosure, a ce orouaoner cosure,c a vecor oeresen an aarmace eo oeresenscosure, ore an comnaon oa- reaeo aarmaceuuccaao arcmcueaaone, cuarrreerr.nnc suomne a as ceoc-s,eraeeeucnuesescreeren eraeuc aens eecveoreamesease o c aen, werene co- n some asecs,eecnuesescrre a semrenom reaeereo. ano orramenereo oeresenscosure, ao o a ncun:a an orramenereo oeresenscosure,c nuceoe encone ano ouaonereo oerese a vecor oeresenscosure, a ce or ormuaon nscosure, ore an comnaon oa-e aarmaceuca n o somee aresseencs,scosure or an comnaon oa-e. uann aorr eecnuesescreeren reaeo a meo oeecn anor seas eaeeocan, anoranosn aorreaenecon, anorme een a suecn neeereo,ncune se o conacne ano orramen ereecon o aneorresueannscnosuere am woun a oooorrecaae sameeoromcanen suee scamn nee.eereo an ^ orreaeen somoe acsanecss, aeorreecanuuresoersecrr,eorreerean a reeaeo a meo wereneaonca,orrea anerson,orr ,orreaarn,orrea orre easse,orrea snca,orreaur,orreaanu, onesaar vaeasana,orreausanae,orrea seman,orrea mamoo, or aorrea ooca sanm soo em oec aasn. ee scus,eceaesc anreuaeesr amesocurne oeorreren raeeaeeoo a mceano as c woerene a reerence or co mareo n somnero as saemcs,e. oor eecnuesescreeren reaeo a meo wereneeve aeasre aaoeue,o aecaasn anoueoo, acaea ssam aoeu oe, su aeeacss aoreuaera,n a aeas aou, aeas aou , aeas aou , aeas aou , aeas ao eas aou , aeas aou , aeas aou , aeas aou or mou , aeas aou ,evene reerence or con re comareo a corresonn conacn ann soemeec anse acns,ro ore sam uaencen. nuesseesrcorrmeeren reaeo a meo werene ooca sanm soem ceom asrescess, sneoveacnuue osr seerscreeenre vnro r.eaeo a meo werene comrsesrnea sonmee as suecesc, wee ocnen oru mesoreesucm er. raeeeren reaeo a meoaurer n some asecs,eecnuesescreeurecn a reeans. moreeraeuc aens comrse eo a meo werene one or aonuce a an ano orramenereo oeresenscosure ouaonoereeo o oeeresreensenscsocsuorseurec a v aecorar omaceeuresenscosurec a ce or scosuree aeraeuc aen eec caormuaon oeresen comnaon oa veoreamesease or a smomereo or an moreerane suomce- a aes. enecss, comeercsen anue asnescreeren reaeo a meo werene one or eocan-seccroase, or an comona ooneereore.senn somsceo assureec,s a,ne aneconcu,e as ^ ceescrraxeone,eren reaeo a meo werene anoc comrsesoxccne, amoxcn, n or so an comnaonereo. occurs aereemcen as anecos,eecnuesescreeren reaeo a meo werenrean n some asecsr,aenoesn. conacnserorme wn aoucn weueess aesecrr suseeceerenne recaoen wo a a meorroea we oerreannse n some asecs,eecnuesescreeren reaeo a meoe m. oransmsorreaurorer,orrea ae,orreaa orreae anrerersoanu,sorreasse,or rn,orreaaonca,orrea o rea snca,orreaur,orreaanu,orrea vaasana, na snoamee, aosrreecsa, seemeacnn,uoersreeasc mreamoeore, onrnocrrueeaonesar. orreaeeocansease or smomereo, ao a meo orean a anormesease or a smo rreaenecon or a smomereo, ae an ano orrameneremo oereoernes ae snuescconsu nreeeereeooanuncceuoese a om anns oenren o erreesseennssccoossuurreecee vecaorrm oaceuecraesenormuscosurece ce orouaonereo o comnaon oa-oe suecn aon oeresenscosure ore annn, onr a smoemeor aasnec osn,e oer meocren nee smuese omere ssoc or.emerenncue a meo o reucn,n a suecn neeereoancue e anororreaeocansease racmenereo o s amnsernoe suec an amouna an ano or ve eresenscosure eonuceoe oeresenscosurece aromra oceuecaresoernmuascoonsu oreecreese cne osrcoosuureaonereo oeresenscosure e n some asecs,eecnuesescr oree an comnaon oa-. amnsern reuceseeve o one o erenncue a meo weren comareo a reer r morero-nammaor meaorsne suec morero-nna smommee a an osce rec or mse, a co aen orerco.nuesescreerenncue a meo werene one or comnaonsereo. s comrse-α,-α,-,-,-,-,-, or ^ one or moren sroom-ne aasmemcas,ore mecenaouesescreerenncue a meo wereneeve oeas aou , ae rss reuce aeas aou, aeas aou , aeas a as aou , aeas aou , aeas aou , aeas aou , a conro.ou , aeas aou , aeas aou or more comareoe reerence ores amnsenre so amne a asecons,aeeeracenuuce aseensc.rne someere asnenccsu,ee a mecenou weseeresne suecncue a meo werene aonaeraeuc aen creeren eoca comrses an anoc or a nn- sseccroase. anoc comormsees asoxeccs,cnee,e acmnoxucesn,es ccerreaerenncue a meoa werene eeocan-seccroase comrses an amxoansee, o orr a comsoznameo,n osrcereoo,a weren n some asecs,eecnuesescreerenncue an. as ors susece oavnme arrs a meo werene suec cnca mane , neuroorreoss or oermesease-reae wecome aessea ar aenons n o. oero asseeacvs,n o oercsn,area sures,n ane a arva unaone cso onseer eaxaomn oe emeooomens eaeescron o exame emomens. wn oan n unersann oeeaures an avanaes oeresennvenon wen wece rerenrcenceeso oeeonvoewnnon meaaee uesczre,o ana sesorusrave emomens, .- sows a ra mmunzane accomannrawns o wc: urorer muroees on srae an resonseoorrea oses o.urorer.ewooewcaeneanaaeeenaess weerenmemurnazmeen evsermur woeees w o anmas wereeseor ano ers aansnurc-- es. . nurc--a--u-amma--rn . , oa--u-aa--rn, nurc ..nma was useo coec senocesrcc-cc- conesor secc aans eacramen aove. anes ce ^ neres anor c.oun caenrseeemcoonns.raeer re scnemen o ce cones seccor muroees o seecon aanse common reeasereeennocan craem ceonnses, an suuse was useor couner sra ornurc--a--u-m ac., ,rc,- a-a--u-- seeceorare-scae recomnan mrouco n were oneres. nase oner seccorare anens eocan.v-e. caunreomroerns.rae.urcaurone an m anas ans o c seaecns m were a onn reease - .anes- corresono ms, , , an , resecveaze s usn recomnan moeec reeaseeocanrese .. oown cuure exansonse nn cuure suernaans resusncae n mea ornaceocanrom cesnac .e .a s aowour m are caae oeecn reeaseeocan. sease causn s ara w resusrommmuno- oeecramens ome .or sreowase a sercaes weocan. recomnan monocona anoesor reeseucsnrorma amnens o re aessaa evauan comnaons o onece mce seeocanne serum orreaee.. sows a reresenave wesernoemonsrane ecac oe an- eourceasn aenreno areesooreuescraovrereuareoseesocanne urne onece mce. scae. on an are no necessarrawno sscosureeorse noemreseenoscaroscuurears emescormeennsreesacerrea,soe unersooa var.s asooe uner e, an as suc ma, o course, arcuar em sooaeermnoo useerensoreurose oescrn noessmeens on, ans noneneoemn. meann as commonne un oerserowose, a oneec onc oar ann scencerms useerenavee same eons.ou an meos an maeras smaarr or s euvaneneo aroose wesccresesrceons cuarne ^ a arseo noew useescrneeracce oresn oeresenscosure,ereerre meos an maeras e meos anu. orca maonesr aansnaens cens seccaon are ceoscose anescre ucaons anaens ar connecon w wceucaons are ce. suc aen were seccae anerennvncouraoraenca reeereoncees asncor eaocraenvua reeurenccea.onuc or cnceorouracoanons r aenerenaceenss a enxreosess nom exeenoo aen meexocosr anor maerasescrene ucaons anaens.nexcoracaenon acaenonsrome ces no aso exress reeaenensan a neucaons anaens cea noe rea asenn anerms caon sou noereae as suc an sou ucaonsorsscos aearnne accomann cams.e caon o an aeresenscosuresur neor enoroeeo anneaaee su acn suouca noone c vonrsureu oe arso arn ascmossson urer,eaes oucaonrove coueerenrome acuauc ure. ma neeoeneenen aonaesanvua ems womeen asaeresn co cronromsee o. sne ar uon reansscosure, eac oe wc mae r e anusraeerenasscree comonens aneaures emomens weaou seeaarranerroomm ore co scmoene or w sr oeeaeurreesse on ansc oosuree. oner severa meo cane carre oune orer o evens rece orn an oe rece osse. r orerasoca anoroe oereer aa rrancuears v eaxueresse, aurer asecncuesrome onearcuar vauenervenn v .ere a rane o vauessrove,s unersooa eac oerwse,eawueee,noee uener a onoew uenrm o oeoawe rranme an une asns oee cron saexe c oerarnecaes vauena sae rane,s encomasse wnescosure.e rvenn ese smaer ranes maneenenencuene s uer anowerms o encomasse wnescosure, suec maer ranes an are aso eree sae ranencues o o an secca excuemne sae rane.ncuems are asoncuenne oreosc oosuree.mors e,x raamnees, e wxceurene e saeer o rranoe oncuosees ^ onne oerosco osuree, e.m.,s,e ranreasse ex “cxuon” enceur oersoe ra oneosrencuems are asoncue reaeran ‘x’ anessan ‘’.e r om ‘x’o ‘’ as we ase rane x,, z, or ane can asoe exresse as an uerm, e.., ‘aou ‘aou z’ aess ws’e an as soeu raneesn oer ‘erseseano xn’c,uesseaen se’,cc ranes o ‘aou x’, ‘aou’, an ‘aou x,, z, orreaer’ sou an ‘essan z’.ewse,erase ’, an ‘ao enerreeoncuee secc ranes o ‘aou x’, ‘aou aon,eu zr’a ases w “aeou as ‘x’eo ra ‘n’e”s, w o ‘erree ‘axe’r anan ‘ x’’,reaeran’, an ‘reaeran z’.no aou ‘’”. are numerca vaues,ncues “aou ‘x’ exresseer seonun ae ra nnoeeormaa ra.o ws, conecenurraeorn usn, aemrsouonos, aan oeer numercaaa cane ranes are sncanon reaonoe oer enon, enons o eac oe enon.s aso unersooaere are a nume anneenen oe oer vaues asoerenscose a r o vauesscoseeren, ana eac exame,e vaue “”sssc “oaseo,u”ena “aoaurcu”ars v aasuoensc aoseo.naonese c vaanuee exsere.or eren asrom “aou” onearcuar vaue, anoro “aou” sse wen vaues are exresse as a anoerarcuar vaue.mar, unceorsseoo,enaearc roxmaons, use oe aneceen “aou,” we s uar vaueorms aurer asec.or exame,e vaue “aou”s us, soues “o” nere us ren a eesorsno aoscose ea. suc a raneormas useor convenence anrev, an rece asem xe manneroncue no one numerca vaues exc r s oe rane,u asooncue aenvua numerca vaues or su- raencees. enocomusasrsaee, a w numnercaa r raannee a os “a eoauc n.umeroca v”a sue an su-ranes exc no one exc rece vaues o aou.o aou,ouenerreeoncue e.., aou, aou, aou, an aou aneu asoncuenvua vaues . aou o aou. aou.o aou., s aun-ranese.., aou.o aouoerosse saou.o aou., an^u-ranes wnencae rane.^ enerae meann as cnn oemsmsons onene un oeerwse,ecnca an scencerms useerenavee same erans.enons o comrmsooonerm osn aen oe ocrnnaures sn monecuea arrooo wc masescosure oecuaronn:aoraoranua,ndeon amroo, ounn oecuaronn:aoraoranua,theon rsc, ananas roocosnoecuaroo ..usu reen anamroourren nzmoo caemcress,nc.: e e a. es.e sereseosn ames, aens..aor e :raccaroac ..acerson,.. no s.:no ..reasonrea,oranua,ndees,onaoraor..anrueaene e.aronwm aaneane,u eus.re: e en.enamnewn,enes,use ones anare, acwece rew e a.es.,enccoea ooecuaroo,use anoecnonoce: a.,om oer.eerse.,oecuaroo nreeeonnsv ee aeseerence,use users,nc., e.,.e onsewor .,conar ocrooo anoecuaroon ecan asnms ,.. ,arc,vancerancemsreacons, oer a anrucure e.,one onsewor,.. enn vanonseu ors ceonm,mraonnseernmcs anouseecneuoess ann cemrosocro as,ndeo annar.en. e thounnm.rancness,use cae n oranc cemsr can em es.r,th, euonse uearse earsonrownm ec a.r,ess.emsrn,dnoecoe en ara.csenccae xornversre son,aen e a.,rancemsr, e. ,use anecansms,the.ssa,reu anseuner,rnvearncearer aanncunemers,r,vaarnc:rucure emsr,ar:eacons anness,the. ,use rn eranc ancore,rancemsr,rucure anunther, anoar reeman. con e. use .. ar anenons o commonerms, anass, anthecnuesnenecs caneounn e.., ress.uasr.erncoeos oer.oeunaeocsn:ennaecsss. an.rnc,esu,tshe.x,orunsveers ^ ucrsawe srn eea.,enecaanassoran annmareen.rs e.. nmareenxrernmeernnas.onausn reen,..enecs anroa n nmareen.nd.us,euserenceaaraveaouron,..nersann reenorseaseessance ovesoc.rs., anaravar.enecs an .asscaon oenecarancennmas.rs use caemcressasso, eae,.anoo onmareen anene.cs,,u,sueseasmoeerence m,uos.e.,onameercoanse.mnccueonsenr eeece.nass oenes annsecnromuemsth. . ,u a.,omuaonaenomenass. enomes, anse rner-era s useewoerresn,neu sanroes.rd,e.wo,ruseneee,.xorenencvernsassre:ss.enes, reerens une uarorms “a”, “an”, an “e”ncueo snuar anura sss usee coenreenx, " caeaoru," "caaersox omerwse. connecon w a measurae v ae," “susana,” anee, wen usen ee, ar arae suc as aarameer, an amoun, aemorauraon, an exermenea m eerarnorow enccom canasse vaeraermonnse o an e.ro.mvene saeac see, a vra aucecenceu snaose wn w e.., aven conencenervae..,, or more cone nar, anor suc as varaons o- oress,- oress,- ncenervarome mean, e sece vaue,nsoar suc varaon oress, an-. oress o anrom s useeren,eerms “ s are aroraeoerormnescosenvenon. e amoun or vauenueasooun, c”a “naeroxem exaaec,” v “aaue or o ar aou va,”u aena “surosvanesa e”u cvan meana or eecs as recene cams oraueren.as,s unerso aen resus ormuaons,arameers, an oeruanes an c oa amouns, szes, u mae aroxmae anorar aracerscs are no an nee noe exac, acors er or smaer, asesre, reecnoerances, converson e ar, s ruocunan e ou,v maeeansu rreesmuens o errr eore acns aree oea, anne. one sromaceo crrscunownoose o sn roves euvaen resus or eecs cannoe re msances,e vauea ormuaon,aramee asonaeermne.nenera, an amoun, sze, aou” weer or nor or ex oreesrsua snae oro caera scuecrs.css “ uanouer,s”o “oaroaxm waee,r”e o “ra “oau o,”r ^ “ saecrocxmuaane,”a orv “ea v oaru aeouse”,s u unseess seeore auanave vaue,earameer asoncuese s use eren, “amns cca sae oerwse. en evere anor suec receevrnn” sa reerso an suae amnsraonore aens sucuaneous,ranscuaneous,ran aens an cane ora,oca,nravenous,nraerma,nravenrcuar,nraossseeromusa,,nnraroamcuuascr,unarr,acnrarna-ao,nn,raareernoernaea,,nnrar-aareserooe,nranasa,nracarac,nraarcuar,nracavernous,nraeca,nrav na,nracererovenrcuar,nramanc,nracocear, rec rea,nracerera, an sens or va anmane reservor or oerevcea aam, vana, naaon, caeers, e.. uson a comosoneervascuar sace an ansveers, eer acve orassve evce suc as a sen can conan a comoson orormuaon na.or exame, a meca enssove ore oerwsesrueoe surrounn ssues anose ons surace, wc can canncue sucuaneous,nravenous,nramuscua ces. eerm “arenera”nraeca,nraeac,nraesona, r,nra-arcuar,nra-snova,nraserna, mnsraon roues cane,ornsanc an nracrana necons ornusonecnues. eecro-osmoss, eno e, aurcuaroc,ucca, conuncva, cuaneous,ena, exracor cervca, enosnusa, enoracea, enera, e ura, exra-amnoc, arera,orea,emoass,nraon,nersa,nra-aomna,nra-amnoc,nra-nracauan,ran-arraccauvaerr,nonusr,anraarca,vnarra,rnonrcaceare,rna,ranurrascas,enrnraac,arnraacc,nracaranous, ena, nracoronar, nracororus cavernosum, nra ornea,nracoronanrauoena,nraura,nrae erma,nraesoaea,nerma, nrasca, nrauca,nraesona,nraumna,nramac,nrameuar,ranasrc,nranva,nraea,nraocuar, nraovaran, nraercara, nraero ramennea,nramuscuar,nraumonar,nrasna,nrasna,nrasnova, nea, nraeura, nrarosac,nraoracc,nrauuar,nraumor,nr nraennous,nraescuar,nraeca,nravenousous,nrave amanc,nrauerne,nravascuar,nravenous,rraon,arnea nousr,nravenrcuar,nravesca,nravrea,onooress, oroarnea, oer, nasa, nasoasrc, occusve ressn ecnue, o amc, ora, reca, ,arenera,ercuaneous,erarcuar,erura,erneura,eroona, sucuan reeosusr,ao surnnuaa,a sounm,uc roesrao,uoar,ca s,oranssseurem,a, suraarnascmnuocos,a, surcaonnsuanccenvaa,, ^ croamnsrnacaeoan, oranes amovaen ac,m unreserraa,on ur reoureas,, w ancor vacanae amnsraon, anor anreae, suecenreae, anor aensen amnse ens oneseaseoe secree,s ex ucsreeeere,n o,r a o “eorwoseca con saamnne” rearer osor or ae r soa. mm ae oooance erom, mae, same can conan woe ces anorve ces anor ceers, an n.ooc vrusarces.eooca same can conanore or ceroucs, anor ooca same cane oanerom an envronmen erverom a “o u”.e uc sames are aso reer e.., waer source, so, ar, anee. reerso a reoeren as envronmena sames.s useeren “o u” woumna noonn-s uoness ex ocreerwons,e se screecone, o orr os aeraruenrroesmenene asnc oransm anncues, u, aueousumor, vreousumor,e,oo or roneren, amnoc reas m, cererosna comonenereoe..asma, serum, ec., exuaes,eces, u, cerumenearwax, ce, cme, enom,erm, ran emae eacuae,asrc ac,asrcuce,m, mucusncun nasa sna oe, a snemen,e smuu,me,r scanrovaauu,, sewreaon,eeaars,u ur,ne,e vuaranau,us, reum, sava, seum o one or moreereo.ooca samesn secreon, vom an mxures o us.o us mae oanercoume ce cuures,o us, ce cuuresrom coecn or samnroce an oransm,or exameuncure, or oer ee,ose usee,e orrenro, “u ernaresm. eneenra” as uenseoes arouorooun ose seeccea,oon we ree,e orenceo a suc asca an- anor-ermnaruncaeorm oeee,oee,rroen, reera, aramen ma comrse aeas aou , e.., aeas orroen. ,reera aeas aou , e.., aeas aou , morere aou or aeas aou ane morereera aeas aou or even aou oe ameran aeas aou , o saee,oee, orroen.or exame,nsoar no o ac seuenceenenee,oee, orroen, aramen mancue e axc seeneen oeu- amno acs, or consecuve amno acs, o euence o consecuve amno acs, e.., consecuve amno acs,r suc a csonosrec euxamve aemno a cconss,e ocurve a cmonnsoec aucvse, ^ e o..,e cor,reson,n,u-e, , , , , or consecuve amno acs crcumsancee ore srums “oueonnna m”a ore o “roe mao,nao no”e o mceaen,s orereronena.e suseuenescre even, weree even or crcumsan cur, anaeescronncuesnsances e recaon o ncuem oecrcucars a rnansances wereoes no. susume wne resecve r nes enonsncues a numers anracons s useeren, “armanaceesu, acsa we ac acse rece enons. excenas useunr eae carrer or excen” reerso a carrer or ans neeroocae ora orner awsear umnaceesuracae,o arnmunacounesa a csarerneerra or e sxace,e nnon-oaxc, acceaeor veernar use as we asumanarmaceuca use. “a s acceae carrer or excen” as usene seccaon an c rmaceuca an one suc amsncueso one an more a s c uasrerer oerre enx,c “enar.maceucaormuaon” reersoe comnaon o an acve een co,m comosoounn s,u oranereorena wnosc a,earramaecueuc,c oarre avcecnevae ue carrer or excen, man eerms “suec,” “nvua,” an “ae sen vro,n vvo, or ex vvo. reero a vererae,reera a mamm n” are usenercaneaereno nomeo, murnes, smans,umans,aa,r mmo arenmreaes,ra sor a anummaans., anamemsa.ssnscueus,e c,eus a are erroen o aooca en oanen vvo or cuuren vro are aso enco n suec cane an oransm caae oennece w or oerwsearmasse.e vecor.urorer. ornsuc as a an exoenouss n uusececer aen,eerm “vecor” ors usen reerenceo a vece useonrouce crcua c seuenceno a ce. vecor mancue a moecue,near or oere..,asms, wcncues a semen encon an anoroee oneres uornanveroucnoenon ao aoosna ce se omrenoss caer oorvaneeoers.surcans acroonna an se omeonnsaransaon romoer anorermnaor seuences, an can asoncu canncue or more seecae marers, a e one or more orns o recaon, one eneraerveromeas orn eancearncaer,e anomoca orenasamon sna, o,r e vcr.axress, oorn m vaec coorns aarne ^ e ceems.enxs oressoon. vecxorress csaonn vee acoarse canore ex araesseononr exressonnroaroc or euaroc xresson vecors cane aaeo mammaan,una,eas, oran ces. or oer aona semen r exressonn a secc cee vae secc reuaor arcuar c sa canroveor recaon an exresson oe vecor wn a seeaseerm cau "e semee. exseraacsee"uaarso srnoocwena asacmereaororreoss reerso a zoonoc, vecor-orne oenransme eerom annececemeenusorrea.meseases mosransms.urorer vas savaoeuman.u.exoesc.enece nmac meseasesesnownore caracerrnsoo mea.ncaresenaon o croncum mransu can ason scu's-ee rasasonown as erema arraa, acroermas, cue mocars, caromoa, arrma, arrs, onecon.m menns, neuroaes, anaca nerveaseenn one sae ocaze s eseaseeneraasree searae saes.aesnown asear common caaera acner ozeccurs a erroexmmaa meransaas re - " muon's-e ae"er ransoc sueeano ans. ana erees mos crce encrcn aene cenera exans ouwar.s snesons o maous e smoms, suc as maa, arraa,eaace anever.e unenoowe u- roressesoae orearssemnae sae, wcenera reae,esease aer annecon.urnaeeacera movenoeo occurs wees – mons ano moresanssues an orans.euro o sreamrome se onecon occurns saencue menn oca, carovascuar an arrc smomsa aesnown aseaes, crana neuroa annermennammaor arrs.necon.moms c ssemnae sae an occurs mons –ears aer anna arcuar o anecome cronc an canncue enceas, menns, an arrs ce wa, reereseoremn a "ee oe. meor cocnasns"nas oo snuowarns a asn mu armenno, a ac masora comonen oeacera a surrounse coasmc memrane o amos aace orms a mes-eaer suc asorreaurorer,orrea ae,o rancunorreae oransms anerson,orreasse,orre rreaarn,orreaaonca,orrea orreausanae,orrea semaan sn,cao,rreorare maaumro,oo,r orreaorarenua,onoersreara. vaaes suanaar, ^ c aocemomnuenram cocns acss o aern.anac reesuoes oe--ace,mnureamc-a acces aucoesamen cean o an- ve amno acs.eee can cane cross-neoeee can o an reeo ormne mes-eaer.eocan serves a srucura ro oer sran vn srucura sren, as we as couneracn eneacera ce wa, eocans asonvovennarsso e osmocressure oe coasm. neaveacera anorrea nurnacera ce reroucon.nram- ouer memr e,eeocans no surace-exose, ass encase e croooane.ooseav,..,: e a-.,aev.coroo ,:- e,.., o neweocan maera, ao accommoae cerow anncororaon eneraonar e a.,crooouo oee exsneocanserae a ever acera,eeocan o.urorerv, an: oer- .omareo mos oer cemca comoson.eeocan o orreae seces,as an unusua m-amnomeae an mosram-neave anram-osveaceraave eocan o -sne, resecve, aer amno acoson.n conras,e neo acn.uroreras-ornne aer amno acoson.s ornnes reero a ceeaeerm. co "mrecrosmes ana nnuceosc a cce"oar ssm no n "aousra ce"re,s as useeren,sneneo ceno wc a recomnan exresson vecora enne ce, an mae a sucerms areneneo reer seennrouce. soue unersooa ce.ecause ceran mocao nnos c oann ococurena surcccueearn sueencer caeonusuoeoe eroeern mu oa suc a envronmenanuences, sucroen canno,nac,een on orncue wne scoe oeerm "os ce" as us caoearen ce,u are s enae csan usee coevraeenn, oer neornm-c "ovnaeen". reeersnoeee arsesno.caon owo or more moecues. use.ucnaes cane ace ae aso caneenec.e., recomnan cemca con ve usn a we vare o ar reconzeecnues, suc as su usaeone arnen r,ec "oammnnasnernroenroucon. aen or a comoson com " reersoescanroucon o aeraeuc meos anever ssemsrnsonwn aoeorasee suce aenneo a ar. sureeecrr,e us ronue asn o o amens varraoouns ^ sorn aan oro oeesreasrcerneera reorueens onc aumennsrraaveonno,uso,rn eraeronea,nramuscuar, sucuaneous, "arenera amnsraon" as useere xamenecon ornuson.eraseoca amnsraon, usua nn means moes o amnsraon oeran enera annraeronea,nramus econ, anncues, woumaon,nravenous,nracasuar,n cuar,nraarera,nraeca,nramac,nraesona,nraarcuar, suracoarsuaa,r,n suraacraarcanco,n,rnarearsmana,,ra ensruarcaea an, suncuaneous, sucucuar,nuson, as we asn vvo eecrooraon.ernave rasernanecon an amnsere va a non-arenera roue, suc , an anoescreeren cane amnsraon,or exame,nrana as aoca, eerma or mucosa roue o mnsern can asoeerormes,a, ora, vana, reca, sunua oroca. more exeneero or exame, once, aura omes, anor over one ornervenon oererromcess. ss "reear,o"rm "erea onn,, o"r a anm "nresaemrnen a,"n a asc uvsee aeenreno,, reeero ane o oecve o reversn, aevan, ameoran,nn, or sownown or suec we roresson,eveomen, sever or recurrence o a smom revenne ocemcanca assocae w asease.reamen ca , comcaon, conon or suec wooes noave aseasee..,orr ne o a suecavn asease or a orrec weeeerrm a "aaennosss, s"u aser usneroermeno a, reveera nsxso. se maese oors cona caonnee. u.s,eomeermne reaeaooes,ereenn a suec wos suaeor areamen. see asease- can mae aanoss oneass o one or moreanosc marere..,e rsan eocanaso reerreoeren as a “orreaeeocavne oorreae seces urorer,orrea ae,orreaarn,orreaaonca, ”,e.., aorrea sse,orrea snca,orreaur,orreaanu orrea anerson,orrea orrea seman,orrea mamoo ,orrea vaasana,orreausanae, anoes aans aorreae sece, anor aorreaonesareocan oreve o orreaarn,orreaa seocan,e.., aorreaurorer,orrea ae, orreaur,orr onca,orrea anerson,orreasse,orrea snca, orrea mamoo,e anaoarnu a,orroerraeaon veasaarsanea,oorrecaan,us waenreae,eorreresenace s, aemseannce,, ^ a amsoeunnce, o or caen ceonn amoonu.nn o someea emnooscm menars,er ansnncrceaaseven oeeresence, sever, or eocane.., aorreaurorer,orrea ae,orreaaeve oorreae orrea anerson,orreasse,orrea snca, rn,orreaaonca, vaasana,orreausanae,orre orreaur,orreaanu,orrea onesareocann aooca sa seman,orrea mamoo, anor aorrea omesease or aorreaene amee.., snovaurom a suecsncaveneeve o an con or aorreasease.n some emomens, anncrease ae,orreaarone,so arraensaaoorrnecaa,eoerreoa ancaenrsoen..,, aorroerraeasseur,ororerre,ao srnrea orreaur,orreaanu,orrea vaasana,orreausanae,o ca, orrea mamoo, anor aorreaonesareocann aoorrea seman, snovau or serumrom a suecsncave omesease o ca samee.., orreasease.eerm "anoss"oes no ree r aorreaenecon or a asence o aarcuarsease orsore roe a oeermneeresence or oucomes moreeo occur r w accurac, or evena aven course or "anoss" reerso an an no.nsea,e se arsan w unersanaeerm suec.n som ncreaseroa a a ceransease orsorersresenne enn a se emomens,eerm "anoss"ncues one or moreanosc meos o ru, aone oreu neerc cm w om "oenraaas oeun wcmae a esea noesce. erve aemraouen" as useeren reerso an amoun o a sorern a suec or reucee rs uc aen, eecveo "rea" asease or e..,mesease ,oena,oss or occurrence o asease orsorer an anormesease-reaeaooes, e.., arrs, neuroocasorer, ruo orrn aamermaaeuorc c aonenona.rov “eesra soemuecamro eveemcenve o armoeunne”noc au suese acn amaoun o a rs oavn asease orsorere.., aorreaenecon.e., an vn or a seces or aorreasease.e., asease cause necon w aorreae mesease-reaeaooes, e.., a aorreanecon,mesease anor conon.us, a "eraeuc rrs, neuroocasorer, anornammaor oss or occurrence o aaseas ee oercrvoev" amesounsors aenr o arm sooumne aaev reauocnes, me rsa,ono, aennaor, ^ reseuacsees o areass onencaore.., arrs, anorecreasen aeas one cnca smom o a annecoussor a uese ner. anereorn m, “oanu-anee ocrnve” reesrs acov com,nouens or moecuesa can eer sucasnecvs reuce or emnae anorecseva, recaon, anor srean assocaesess severe or emnae.n-necvesnc se or smomereoas anaceras, anunas, anvras, an anroo ue,u are nomeo, anocs, nomeo, amecese.., nazoxanzoas.uae an-necvesncue,u are coroune, meosne, amoercn e,aromomcn, meronazoe,nazoe,oramcn,enamcn, amac , anoouno, amnocosese..,aromomcn, meenazoe,vermec n,anamcn, an neomcn, anemncse..,rane, e.., azoe anunasen.,.,rarzacounaanzeo,e, auecnonaazzooee,,oasaceonnaazzooee,, oexoacmonnazuonee, anunas mconazoe, an vorconazoe, ecnocannse.., caso , cormazoe, rseouvn,ernane,ucosne, anoeneunn, anuaunn, an mcaunn, anmaara aens e.., rmeamnessuea..o,x nnesan, an amoercn, aovauonerouan,unne,roxcoroune, me , aremeerumeanrne, rmeamne, anaoanrne, anuercuoss a oune, coroune,oxccne, sacc ac,sonazramn,sonazraense.., amnosacaese.., amno eamuo, ramn, raun, raenne, careznameramn,eaune,sonaz, amanane, rmanane, aacavroamcn, an ccoserne, anvrase.., cocsaeveravremrcaneenoovr, mvune, eav emrcaneenoovr, aacavramvunezovune, amvunezovunerenzemrcaneenoovr, emrcaneonavrronavrenoovr,nereron aa, emrcaneenoovr, maravroc, raeravr,oueravr, enuv -vravrn,enereron aa-, nevrane, eavren re,oscarne,omvrsen, oseamvr, zanamvr, aeo z, eravrne, rvrne,eavrne, nevrane, enecavr,amvune, zacavr,ne s,oeosuvvur,ne, samnoesrneev,r,enoocoevrre,v ar,aceaavrr,ev zr,ovounnave,r sraovnune, emrcane, arunavr, ronavr,ranavr, aazanavr, nen avr,osamrenavr, vaaccovr, accovr, avr, amrenavr,nnavr, saunavr, ravrn, orenem, meroenem, eraamcenceomv,r a,na cncascaovnr,m anene vma,a cneccaoovsro,rn casrea.e.,ne cmesaroex..,, ^ c ceerroazn,e,or caecaarzoen,, c ceeoxaenx,n c,e caecoer,m cee, ceueanro, cnee,oracare, ceoean, ceuroxme, cenr, cexme, ceoren, cezoxm raxone, ceoaxme, ceooxme, vancomcn,aavancn, oravan e, an ceazme,coee anocse..,erosacse.., coazmne cn, aneavancn,cccnese..,eccne, cnamcn anncomcn, an maaome,ncomcn anervavesereoe.., axomcn, erromcn, az croes anervavesereoe..,,eromcn, nezo, suameoxa romcn, carromcn,rromcn, anroeanomcn, meronazoe, azrezoermeorm, raxmn, coramenco,osomcn, carencn, eroanam,acracn,encnsamoxcn, amcn,acamcn, eracnazoacamcn,carcn, amoxcncavuanae, amcnsuacam, coxacn, an n, cavuanaecarcn,encn,rocaneencn, oxacn, crooxacn,evoaocxacnn,,uenmoonoexsace.n,., moomxeooxxaaccnn,, n conroxoaxcacn,n, n oaoxacn, moxoxacn, reaoxacn,aoxacn,rovaoxacn, an saroxa xc ac, enoxacn, suameoxazoermeorm, suasaazne, an su cn, suonamese.., oxccne,emecoccne, mnoccne,o asoxazoe,eraccnese.., ounsauraea acs, aneraccne,xccnesacc ac,oxccneomea- meenamne,osomcn, c an urnar an-necvese.., nrouranon, eerm "anoc" as usenoxacn, naxc ac,rmeorm, an meeneue.^ anocs, usua ose erenncues a common useacersac anacerca amacn,enamcn, amnsere ora.nocsncue amnocoses, suc as as ceamanoe, ceazoann,a cmecan,ex neno,m cecna,o sreconm, cecn,a aonroner,a cmecano cen,a ceosoarnrsn, suc cerane macroes, suc as erromcn anroeanomcnencns, s , an , amoxcn, amcn, carencn, coxacn,coxacn, mecnuc asencn enecn, ancarcnoee anocs, suc asacracn, c, nacn, oxacn, omxneraccnes, suc as coreraccne,emecoc osmeae, cosn, mnoccne,eraccne, an oxeraccne a cne,oxccne, meaccne, coramenco, cnamcn, ccoserne, n msceaneous anocs suc as an vomcn. ona anocs a ncomcn, ramn, secnomcn, vancomcn, .,acu.o., ,.re-escr.en "emnon'sarmaceucacences," ^ roenese usseeren w reerenceoe reaonseween , c, c, , ree , anee “corresonno” or “encon”usenercaneaeren srsnoee ar un weorun uneorsoanca raea ooenrasvee “wcoerernesoesneneore”n ca mnoerceuces.s suc, one o eosse unern anor resun seuences o oer moec emoeermne oer moecue wcas a smarooca reaon uesvene seuence o an rom a seuence an seuence can s wese moecues.or exame, seuence can eeermne anrom an seuence a c s ueseermne. o orn eeren, “suae conro”s a conroa wensan arecae one en evaaru sne ar as oneasncue suca caneeermne e varae e ar w aaseo anns eanec, a sucrec aas aeeassere on enecer o ara,oe ceosnzeex e,eec v.arnae oes o,rneares sn oesze eec, was a suae o re or aro r an arorae conro neee. emomenus emomens areescreerenaer. soue noeae secc scusseesr aerne. nonene anseec ase asnc erxeausnve conesucnrcoonn w or as a amaracuonaro eeroaer asecs necessarmeoa emomen an caneracce w an oemromens no eerencerouous seccaono “one emomen”, “an emomens. emomen,” meansa aarcuareaure, s emomen,” “an exame w e emomensncue rucure or caracerscescren connecon aearances oera n aeas one emomen oeresennvenon.us, emomen ses “n one emomen,” “n an emomen,” or “an exame same emo”mnen va,rouus maa.cesurreorumooreu,es sareccuacraeoanu arrees n,o sru necessar a reerrnoe e comnen an suae manner, as wou cures or caracerscs ma scosure,n one or more emo e aareno aerson sene arromsncue someu no oereauremsenncs.uuerenrm ooreer, e wmoe sommeen esm, coommneansonses ocreeaureerse on aeernene e cmamos,m aenns o aree m ceaanmeo eme womnense ca scnoee u oseen annve cnomon.naoro enx.ame,ne erencororuaecaon rse,eruenceseoaeen samoecu emxeenns, a asnouaen e aaccnaovnsu caeuerecano arne, ^ uensnecoraoeraneocum reeenre,n ocre.aen acaon was secca annvuancae as , casese oaomeencse sasero ecacaeeearornreaeu.r. aoroneer.s. esurmaoreero ca cuasuesse a mor-eaannecon we acue saeen caracerze ‘u-e’ smoms sc severeae-saenecona cannvove mue , wcsoowe a caneaa.er e oran ssems an cause severe mor an cn snown aou wa causese cnca smoms anere areew succ aaso rerreevaan a asesaso. aeseor annecoornre,arcuar acvenecon.erorreae seces, s suceres a crca neeormroveaseaarsne car.acaerrnza coann a anso uneaersoanmne asease. meos oeecn.uroreror assessmen an manae nor mesease men oenecon an resun ce wa com.. ousreo ore oruears a snmnanre srcrucouraasmeacu mreesmor oaneesr suorrroreunaenneaas aexe osa,.., e a.,aevcroo :- .enner an orasmcaea encose anaer oeocan.e ouer mem uer memranes anoes no conanoosac rane o.urorers eassrue roensav care . numer o anenc.urorer ce surace s,se aneense.nse. anesesncu aree eneco oueer memranen sueracaenreomenesness wcs are,ranes mcrose-s aus ae sn.eurransocrrero mnaem unraneruroscea,n.s e as.,,. aacero.:- . orreaenesncs ane mos aun oroen anen exresse arour,.. anroen exressen vro mosorreasoaes : , e a.,neconmmun :- owe,.., e a.,cence cemca comom. osareon.o meose ooeraccaner oa, moeseram-oneacanve o an.ruaroreras an unusua m-amnomeae an-sne, resecve m-osveaceraave eocan o.urorer , aer amno acoson.n conras,e neo acne. as-ornne aer amno acoson.s ornnes ^ envronmen.urnounecenon,oune.ueroro,reer. suerso mruerroeeeosncaon casn exraceuarmmune resonsene suec anseeveoa a roe smuae an an seconar con nseaseroresson, smoms, aons. ereo caae o se scac,a emonmnen as.scuroseoreerrene canorocvane. aunr aner eomo ormramen asoroveonuceoes encone ano orramene ens can armaceucaormuaons,s, an me reo, vecors, ces, eocan,.urorerne os oeecn anoranosn.urorer xameseren,ese con anormesease.s suore eorn a causemesea csoem, suocso anss aonrr meea aose can a enxenorroenacuaer oer seces oorreae comouns, meos,eaures, an ava n.er comosons, aareno oneav naes oeresenscosure we orecome oeaee n ornar sne ar uon examnaon oeoownrawns, c scron, an exames.snenea a suc aona comosons, em scooune os, meeroesse,neasucreoss,u arne. avanaesencue wnsescron, ane wn ereo caaesec or seecnc saeveran exnem aarorre emaourmeonrserere.nu arre aonreroees ororacmaens ceran exame emomens,e.urorer an-eocan a n.ns caae onna acan comonen oe.ur no orramenereo cc-cc-anurc,an aa-rnnaenorereocan, oona a amma-rnnaen a.urorereoca a.urorereocan,c a comrsnnurc.n some emom n, or a.urorer muroee orramenereos caa ens,e.urorer an-eocan ano eocan, oo e o seccanna acan comonen oe.urorer urorereonaca acc-cc-anurc, an aa-rnnaen a. urorer m n,c aamma-rnnaen a.urorereocan, or a. euscroreene s ceovmerars exnemnauru arc. comose o orncun one or moreoenoese esacerenne areen aennoaevsn or ara semueenncseeareos ^ -,,en,cao, an o,ne o,,,:-,, suc, as,,oo,r,,,,, anenocao an one o :-.n some emomens,e anos a, mon,ocon oe.s,nnc soumen emoocmoneans ane m aon a an nocoonas an aooecso anrae aenscroe. eseewoers o man areeneranownne ar. ouenoun eor,e anoeseeren an ereoescreeren cane useun meos oeecn ano anramens anor aorreasease,mesease a rrean aorreaenecon reaerea esewere normesease-reaeaooes asescren escreeren comrseesre orn.s onn cee orra mno erxea ome emom:en-s.,n cee arnano exam orrea emenereo e ano orramenereoescreeren comrses a cm momens, ano, or aumanze ano.n ceran exame em erc ano, auman monocona ano orramenereo. omens,e ano comrses a reerenan soom ae eomrreoaemeens,oe ancano ove orr oraermenes oereoac oeraeeresenosccaosurens emomens,e ano orramenereo oeresenscos ns.n some orreaurorer,orrea ae,orreaar urereerenanso a orreasse,orrea sn n,orreaaonca,orrea anerson,usanae,orrea semanc,a,ororerreaa muarmo,oo,rr aeaorraenua,onoersraerae vaaosanaca,orrea comnaonereo over oeres oaceraeocans.n ce n or an oere oaceraeocan comrseseocaneonran emomens,e acus sus, oraococcus aureus.n some noscerca co, ramenereo oeresenscosureo emomens,enn oe ano ornammaor acv oeeocan.n aorreaeeocan reucesero- aorreaurorer,orre some emomens,eorreaeeocans orreasse,orrea snaca a,eorr,eoarruera,aorrnre,aoarrneua,aoornrecaa, vaoraresaa anerson,usanae,orrea seman,orrea mamoo, aorr na,orrea comnaon eaonesareocan or an comrses ana ceer ,re aaon. a e'x, aamae' em, aov,m ae snns,e cea annvosc ovr,r oar cmoemnnaereooneersecor.en ceerreann ^ exroaum ceon esmsonm oen ans,e, an ano, o arnrame,n anereo, a veascrraneereeroen, ans se anec ceomronme ereo.n ceran exame emomens,e ano orramenereoes aon neo an aen,ereormn anmmunoconuae.n ceran creerens ano orramenereos a monocona ano, oo exame emomens,e , or . ouenoun eor,e anoensa an seraecmeensromer-, , eren cane useun meos oeecn anorrean aorreae eoescre sease,mesease anormesease-reaea necon anor aorrea n some emomens, an an-orr ooesasescre esewereeren. anormuaonsereoscoseere eaeeocan ano orramenereoncun,u nomeo, n are eecveoroec aans oer seces oorrea snca,or orreaaonca,orrea anerson,orreasse,orrea seman,reoarreura, moarmroeoa,anourre,aorarrena, vaoarsreanaa, aoerre,a orusorarneaae,oonrrea ccorn,n some emomens, an ano orramenereo oere esar. cross-reac weeocan o mue seces oorrea senscosure can we arecaeae cross-reacon can oc e,ncun varansereo. excree, or oerwse assocae wor cur vann aeocanrouce, orrea snca,orr reaaonca,orrea anerson,orreasse, s eaur,orreaanu,orrea vaasana,orreausanae,orrea reaecmvan c,anorereeae mrmanmeoo, anor srueaaear mne,oo,rnrecua aneu, n ooromrreeaoonmesar.ross- wcs sown aeasneornxameseren.e anoes orramemuno-, eresenscosureoes no cross reac weocan o non- nsereo o wors,e anoes orramensereo oeres orreaeacera.n oer eocan enscosure secca n on eren an reeer reormms "oarnreaoe." an "anoes" areerms o ar an cane usenercaneaerms as useoo a moecue w an anennn sea seccans an anen.e .e., "aneerenncue woeu-en anoes an an anennnramens emomn-nnorons" or sne cansereo.n "ano" reers,n onener-conneenc,eo ascuoroeenon cosm, orr asnn an aeenasnwoneaovron ceraeons. ann anwooer emo cmaenns, ^ anom "aann.oac" reeaevrs coa an sns ceom carnse an oo ae caovm crasnn va ar sne varaeoman, e.., an aeav can consan reon.n ae reonarevaeeren as consan reo ceran naura occurrn anoes,eeav can anoes, eacns com crasen os comreersoema ons a,, can a vnarae. ren coenraan nraevuraa occurrn an a can consan reon.e can consan reons eeren as . comrse o oneoman,erme comeemena arnee rermonnns ca rneoensurer su,nvereno reons oervara, conserve,ermeramewor serse w reonsa are more s, arranerom a reons.ac an s comose oree s anour ,, mno-ermnuso carox-ermnusneoown orer:, ,, omananerac, asn w a.n ane vaerna.ee re coonnssa on reeoenasv o ane an coaness c coanna mne aann nn oemmunoounoosssues oracors,ncun varou ee sseme.., eecor ces aners comonen o s ces oemmune noes cane o anee..,,,,e cas,sca comemen ssem. , , , , or , or an sucasse.., , or,, an an casse..n, mummaunnso, aonuns, e.,.,a,, exsn sev aenra aoesn, w mcce oermrommu enaoco ouernn m aoecue. ew amno acs.n anoscoseeren canerom an oe c mos a casses, sucasses, or aoes.n c ommonnownsoes, , , or suceran emomens,e anoesescreeren are oe are oe , o ass or an rereo.n ceran emomens,e anoes occurrn a "nnooes"r monncoucoens, s a an wuac o oass c e. oxnaame,o naura occurrn an non-naura uman an nonuman ano anoes cmerc anumanze anoes monosecc anoes muses wo snec anoes sne can anoes anoes comrsn ecc anoesncunsecc anoeseramerc monomer an woeav can anwo can moecues an ano can canmer a ann anooeav ca cna mno-annomeor ane aanvo cana crannramoer,es an aenerooconueaave ^ anoocesa mnon-ovae ann anoeosesnc sunne c,a e.n. a,n ano-e asn c-ame anzeo aneso, aes aoes an- anoesss, wcncuenn moecues conssn o n sne-oman anoomana areu caae o anennn a sne monomerc varae armen.. anaar.. croooecne.., a oman or a oman. eerm "anen-nnoron" o an anoo., as u:se–eren, r. ramens o an ano a reane a o secca eerso one or more urorereocan.uc "ramens" are,o no an anene..,. amno acsnen, suaeween a r exameeween aou an aou aouo aou,or exame aouoou an aou amno acsnen, sua amno acsnen.aseen s aou amno acs, or aouo aou or eerorme ramens o ownae anen-nnuncon o an ano can wneerm " au-en ano.xames onnramens encomasse escr anen-nnoron" o an ano, e.., an an-eocan ano , aneereonm,ancnsue a aaa'rarammeenn,, a a movnaoevnaenramraenme cnom cornssnsnwo oaera,, ne ans avs auverarmene a consesnne o reeo mens oma n an araommaenns o con as ssnne o arm oe an a anno, wncs cuonsse-nevssvv a ramenar e a., aure:-, orv a cs o a oman anv ansoae comemenareermnn reon ner.uromermnoareo,n a oowuo or meowreosoomaeans ose wvcra canm oen,ona aneon,e are co a snec searaeenes,e caneone, usn recomnan meos, eor emoe mae as a sneroen cann wce an a snecnera enaes moecuesnown as sne canv reonsaroorm monovaen anuson e a., roc.a.cscv see, e..,r e a., cence:- are asoneneoe encomasa.c. :- .uc sne can anoes ese anoramens se wneerm "anen-nnoron" o an ano. e ar, aneramens ar aere o scareneene usonr u convennonae seacmen muaensnenro awsn aroeose w sn nen-nnorons canerouce recomnan ecn nac anoes. cemca ceavae onacmmunoouns. ues, or enzmac or ^ nercaneas u asne areer ceomn,monenermes ar. "varea vaera ree roen"on or "vcaraeoman" are use ano,enera, aoron o a oreav can a reerso aoron o an amno acsne maureeav can an ,ca aoue amno-ermna o can, wc er exensven seuen aouo amno acsne maure secc o aarcuar ano ce amon anoes an are usenenn an concenraeservneos orsarcuar anen.e vara n seuences con e reons cae comemenareermnn reons s wee more ou re wosnsnnoe vearoauneom anan aarre ccauaer mramewor reons. e s ecansm oreor,seevea oe an ooe w a anneeanv.n c caernsa anre emrmoarmen ress,ones vaeraore reenoenracs aon aunm secc reon.n ceran emomens,e varae reon com an varae ramewor reonss.narc rses roen or murne s anuman umanrmae varae reon.nu cearra emn eommoenmse,nse, vaer vaarea ree roenosn a comrmaee.., non- murne s anrmaee.., non-umanrmaer rses roen or s useeren,eerm "eav can" wenam useewor reonss. o ansnce, e.., aaα,ea n reerenceo an ano can reer amno ac seuence oe con , esonε,amma an mu,ase one o anoes, resec sanoman, wcve rseo,,, an casses s useevreen,,necuermn " sucasses o, e.., , , an . o ansnce, can" wen usen reerenceo an ano can reer o e..,aaκ oramaase one amno ac seuence oe consan emans. cans c aanum amanno ac seuences are wenownne ar.n secc emomens, varae reoneerms "" an c "an.oman" are usenercaneao reeroe can varae reone oerm ans a "no" an. "oman" are usenercaneao reeroeeav can anavess m u o esae an a nnenre cno,e.erm "consan reon" or "consanoman" arenercaneae caroxermnaoronom om aonn ane aorr.eave c conasnan w recosn nos anre acnonvovoeronn, en..,n a ^ oe an acn recoeoro. anee cnonusa wn rce coann e ox an vmamrouunso eoecuornu mnocons, suc asneracon w conserve amno ac seuence reave ecueeneraas a more n "c reon"ramen crsoa anzammeu rnooun varaeoman. ermna reon oeeav ca eon or "coman" or "c" reersoe-oosssues oracors, n o an anoa meaesenn oemmunooun sseme.., eecor cesnc ouronenrsn coomco rneecneorsoc oaee o cna vsasrcoaus c coems oemene smmseune us, anc reon comrsese consan reon o an ano excun m.mmunoounomane.., or.n, an anoseorse consan reon comrseswoencaroenramens,erverome se s,ec reon consanomans oe ano'swoeav cans an cco rneons c anr can consanomans omans-n eacoee can omrsereeeav comrsesmmunoounomans an aneneewee.nor,ec reon eounares oec reon o anmmunoouneav can m va arn,.ou eav canc reons usuaeneo srecrom an amno ac re euman or amno aceweenesewo amno acsoe caro sue aoson or werene numerns accornoe nex a x-ermnus oeeav can, c reon exensrom aou amno ac os anouaa.e oman o auman omansosone on-ermna se o amomann amno ac , werease amno ac o aou amno ac o a anc reon,.e., exensrom aou seuencec,ncun an a n.s useeren,ec reon cane a nave c can aso reeros reooncn vasroaan,on or o ar vanrane ccone.ex., a o no ann-nacu-rcaom orcscunrrnrc. oee suc as a "nnroen comrsn anc reon," aso reer oen roen"e.., reo as an "cuson " anna ano ormmunoaesn. seuenceasveen sceaueoncee acm renoo anc" or se "nuaenvcee o se aunencce rec"on comourses an amno ac seuenceumanc reonsncue a nave seuen nn naure.ave uman c reon nave seuence ceuman c reon nave seuence c reon as we as naura occurrn vaurmaannsereoc. reaovne a sneu neancvee scenucenuceesumea vnarous ^ a:oesu osees osnee,n ee..,c.ee,rs e a., ms: arsson. e a.,ronmmuno.mmunoounn ".cc resceaor"n or "oc. an"s a an recoeo cromansoec reon o anncun aec varans an aernave s rse receors oecam, consss oree acvanc, ceorms oese receors.ecamnumans an onenorcc re,c aenorc.un mcec,c , anc an ecse sronesc eecor man nso mosumanc receors resecoees o uncons.s consere euvaeno murne a weasc eecorunc aocnsv.anarssco rnece. eor as.,aronnmsmuon.o.on:verseu,umsaen onn ecse . ec., one or more ee ceocnosranun rceoonns. cann "ee meacnouae, e.., recomnanecnoo,o emnae reon w anc receor oran, or aroucncemonc"a re eveersnoae rensuerascoenre oro amn. anxemoarc "enecno,rucnc-mones"anecu eeecorunncnon,s co smuce amsenee annen an coooxceen ,c receor aocoss , anown reuaon o a ce surace r en ce-meae .uc eecorunconsenera re eceore..,e ce receor omane.., an ano varaeo ureec reonoe comne w ann cuncon"nc man.ccorn,eerm "a consan reon woue meae cue consan reons w reuce or wou one or more eecoruncons ecorunceoc re nsoro oun an. nc anonso o a cna anneo cane reuce or avoe eren aroaces. ec reone.., suc reuce or avoe usn anoramensacn monomer as aa,a'2, sne canvscv, or a s conssn o a en c or oman.ernave,e so-cae acosae anoes cane eeecraoreunc roemnso ovn an s aunarsoa w aree rneeanona orceur vaar ruesuesnec reono reucee roonea-e aneeromerzaon ae arues oec reone.., exame,een or aern . cosae anoes caneenerae,or enzmaca,roucne anoe rens ceues cueu sreuanrse areascenece oo a, remcoosvnaonen suaorrs, ^ o e.r., e.x.resus.no.e anon c.esno unaere aoroaccossaoe emrooense..,aceraos ces.ee, aave reuce eecoruncon,o c reonsrom an sucass avnowereves o r exame, an anoes are caracerze ene re c eecorunconsan an .e resues mosroxmao a onne oman oecar are resonseor eecoruncons o renceooress asc co onna ense acoarr cees o overaennnaenmnmu snee sosrem.coamrsemen an -c mmuno.: use onnec., .ccorn, an son. e a.,ron c eecoruncons canereare ene oes w reuce or wou omanrom an ran, e.., a cmercc reon wc comrses a oe soe, or a c anmeorc oce soe an a omanrom an ano reonrom see, e.. reon wc comrsesne reonrom an w muaonsa res,au. e a.,.mmuno.:- , or anc reon c reons w muaounsn ar aeenreowncn eeec aorr.uneec, eo.ns.,, e...,. reuce or nocuncons.uc an acaons ceeren ann e a., ms:,u-.o. esc an.. wc arencororae osure o "ne reerenceoer enre. oman o aeav" c, "ann ceonsoamnan re" oorn "naeo renson"e or "anoomannoe reeon" reomerasoencuese uer, me, anowerorons oeneoux e a., n an : .eneroves varneves oex eweenen.nmm anuno. reons o an ano an asoroves sesornermoec eecorwoeav can consan reons.s us uarsueonneweene a soesoux e a., mmeeren, ane sars au an ens a or an nesnownne ar.uneoe, e: .e seuences o w-e , , ommunoocaneres, o ..,aa e a., euences oroens ucaono.- arssn,..earmen oea anumanervces, . on. e a.,ronmmuno.: use onnec., omanoeeenrm " oman" reersoeeav can consan reonnne varae an ens aen a.eaeve crma "n consaonmaonm"annc.uess u wseereen, aomaonms,a ans s waers a as ^ n anaura exncsunn var wansee areno aeo.., aeso areesn.ownnome aarn seuences o , , , sura an arsson. e a.,ronm .ee, e..,aa e a., omansncue omanmuno.: use onnec., .xemar ano, e..,a-e, e s w muaonsa mo aooca acv o an ucaons an u.c.,escren..u.o. an..aens an e omaenernm a " a eav como aans nn c" c o rnee searnseoren oe.eav can consan reonnneneo an ens a .eerm man.s useeren, a oman sars a exsn v " oman"ncues w e omans, as we as naura ncunar wanseer aeno ae.o., aeso arees.nownnomea anr s.eeuee,n ec.es., oaa, e, , an an arsson. e a.,ronmmuno.: use on a., sura omansncue omans w muaonsa mo nec., .xemar e..,a-e anor reucec eec aooca acv o an ano, an..aens anu oruncon, e..,escren..u.o. eerm "caomonasn a"n reerucaons ceeren. e omann a soeeav can consan reonas-ermnao an ens a .eeaevrm c "an coonmsaann"onmcaune.s ws useeeren, aomanso,m asa wne sars a exsn varansereoe.., aoes. oman s as naura ncun w e an aoes arenownne aeuences o , , , an an arsson. e a.,ron r.ee, e..,aa e a., sura omansncue omammuno.: use onnec., .xemar e..,a-cae, ns w muaonsa mo aooca acv o an ano, u e..,escren..u.o. an..aens anucaons an , so unss ,e ce ,e arenne,re "ns.o aneo" reersaos eneco aneo ceasesave. c.,an, , , , "oe" reerso naura occur consan reonenes. varansern ae rn varans wn a seccsoerou, wc escreeren canew o am anno a aocse.see,o e..,ese oers e, a.,, , a mns: a.rennowonens ^ eu ars.eee o,n e.ne.,ca.a, e a an.,era suraarsson. e a.,ronmmuno.: erases "an a nc, ms:,- . anen" are usenercaneanoere rnec wonznee armn a "nan aenn"o an w "anc annos s sececcacoro a an anen." n aans arss ursemarere ann, "aon- woc sc"e ocr "caan-onsoc a annoo" reerso an ano rase useeren,eerm "ooe" or "oceermn oe oers ano.s eoe exresse on ar an" reerso an anenceermnan ormmunoounrouc os ar smnare a cnoneo o. cens s.omne so emmeo emmoenms,enes,oeoeoos uensueoe e varae reon oermar ano.n some emomens,e ounn assocae or reuaorooenermar an ooes aramewor- susananr "eeso oae o aenr anoo,"e ass usaevnerene,o resnn. aenneenco s reeecroc ane ano wcs anoa seccanso.urorereocans su se.., ansoae a seccan anens oeran.urorereo sanaree o anoesneracons "enwenen a a snne"nenenra se re oe ars mooecuee sree.n., ocaen s.umoa o non-covaen e.., an anen.nessncae oerw an ano ansnnarner nn an wc ree se, as useeren, "nn an" reersonrnsc an anen.e an ocs a a mo:ecnueeracoonreswaerenne mrem caenrs oen aeranne rearreese.n., ano ssocaon consan .n cane measure anor exress e ene ar,ncun,uDnomeo, eurum en a numer o wasnown assocaon consan .e ssocaon consanD, an eurum moaA Ds cacuaeromeuoen ooffonans exresse as a assocra coonnce rnarea coonnsan, o w, ee.re.a,s anAans cacuaeromeuoen oonoff.onreersoe e.., an anoo an anen.eonanoo ca ann aeneeenr,m anneoff reecernsouesenoswsoncao oonne o o, ornar, sne®a orr, snuecc a esxcmusmounno aaofssfssaasne.x., en.zme-nemmunosoren assa ^ nn," "sese ucseveernenn,,"e anerm "sse "escevcecans,n" asr,"e " asnaecca reconzes," "secc anoes an reero moecuese.., a oousermsne conex o comex as sucnns noesano an anene.., eoe ormmune seccan unersoo one sene ar.or exame, a moecuea an a so an anen canno oerees®oroees,enera wower nsrumenss,eeormsen,e, o,r e o..,erm asmsaunsoanssoawns,ne ar.n a, sencxc emonmserumenane seccano an anennoe anen w a as aeason, moecuesa os orreaerane wene moecuesno anAoer s,.os,os, o, e.., an ans u-seeeoren,Acane aenrmo "nsscoo ase.uerreno,roer onee an ooenc.an" reersoenn orreaurorereocan.e.ur r more moees or eoes on a eocan or aramenremnanereo orereocan cane a woe r4eecsenoesca n sec.c ene assocaon consanDo-a5oo-11er or coesnsa.en anDenre waeran a aoun,- seccar"ao a cnon anseeren reoernsoca ane a nnonsoeccannns.ose us aeneerne ann, a snu anoa "ns anens w an, wc meansavn a o-7oress,rsana-8enca even morereera-9oress, an mD-8eera-10oress, eermne, e..,mmunoa osreeraeween an oress, wenn a nsrssase.., or suraceasmon resonance ecnoo ano unreae anumen usnereeermne anen,uoes non wo an anoness seceens o.erwse,eerm "an-eocan ano" usee susance, sucsa ae se s aec rroeenc ren reers s u ,a n,eeenrms e, "o oarne aeno e"n. rec nea srns o omoe a. enu mo nrauorraer or. snecmmunoenc urorereocan.n oer emome mens, an anen comrses. reonrece aa ns, an anen comrses an anoe.., varae s usenesren., aunr "eorereocane.., an-oc ano. aneno wc an ano can soeec"csa aermnn.ne e ar aone r ceanerse,o aoro ecxaamzee, re conon ouo auns ^ aomenoe arcrso om awoo oer meorene naorn o-cro cnonuous eoe or an eoe can,or exame, come conormaona, non-near,sconnuous,uo ours no rne-coonnsu oous a eooee.eo oersoormees conuous amno acs areca,u no awas, rean erom wereas eoesorm e on exosureoenaurn sovens, sovens.n e eraron arecaos onreamen wenaurn acsn eoecancues aeas,,,,,,,,,,,,, or amno ven an a uonue.e s.,a eao coen moarmanon. aree weosnoowrnenermen arn. wea eoes areoun a conormaon o eoesncueecnues os oeermnn saa ra crsaor ne ar anoseescreeren,or exame, x- anrooacos,n-emeonssonna nouceceuarar maoneoc, resoon.anc,e a.n.orr-see, e..,oe n ceran emomens,e eoeo wc an anonss c,an.ee. e.., secrosco,-ra racon crsaora sue ermne, roeneuerum excane coue w mass sec s, assas, eecrosra mass secrome romere..,u cromaora mane.., se-rece mrua, aernreas-s masae ono.-oer-rea sc carnnsn assas, anor muaeness e accomse usn an oenown m aora, crsazaon can rsaororsaor :-eoscnereso are..,ee e a., ca aen en crsruacsu crae n urocem:- no:an n:e su-e usnc weersonnown-raoracoenmecn :ues- . e rene usn comuer soware suc as- aenve an can oecuarmuaons,nc. see, e..,enzmo rs, ,srue e a... , a voumes , esco rsaor n rcone carsaor o overs e a.,:-carrcsoanoerorenmo :-, earer man sues cane accomse usn a saor : - .uaeness ame e a., oem:n meonowno one o sne ar.ee, e.., cence: - or aescron o mua-enes asneunnnam es muaenessecnues. cnues,ncun aanne scannn ^ ae anoeeersm "nnosoe saem saem see emenoe o" w amn roe aecrenc reesowo or more anoes means meo.ecnuesoreermnn wee ues, aseermne aven anoesescreerenncue,o r anoesnoe same eoe w e anases o crsas o anen:ano corm exaemxese w, ecoroev meas aonmc m reesoous,on suc as, x-ra an roeneuerum excane mass secromer -. oe eoe nn oe anoo anenramens or muae va er meos monore nnueo a mocaon o an amn raons oe anen wereoss o consere annc o ac resue wne anen seuences oen meosor eoea maon on a cnan e asooee c uosem.oneense. mne aos roen, c oonmeu aaona o comnaora onereso ansoae secc soreesrom comnaor e ano rares.noesavne same an ore same a, aanesaee execeon seuences are nooese saame " ecomoe. anoesan ara oree w anoer anoornno aare" reero eerwo anoes comee comee enn oe oer anooeare. exen one w eac oerornno aare,.e., weer ano wa nown com aneoon exnermsenes.nn cenra on eme ooemr aenns,o an ano aoare co, caneeermne usn nn o anoer anoo aare aeas ,,,m,ees, w,, ann,s or .eeve onon or comeon caneereneenn on wc a ,somee "oonc asnsa asn canoe" con.eu.,cee a csoesc arneo,or exaamsen,cunaears w enaroe. ornarrooc o:. .ro ornaerr oo "w asnnanvane, arow anavane,ornaroraoraorress,orn oes" .omen anoesnoe same eoe, an overan eo aror,, eoese.., as e oro aacen er evence sercnrance. raommunoassa come, sovenasenre acss oarsnnreccu een:zm soemmunasoeassarec o,r snrec comeon assaseea e a.,eosnnmoo: so asaenwrc on-avn seeran e a.,.mmuno.: so aserecaeeec ^ assaa onu,a so,oasernrecaraoerere sassnwc ass saoseeasaerowre acnaaene,n usones-:aaoeraosere roreo e a.,:o.mmuno a. : so aserecon-avn eun e a., . nrecaee .oenauer e a.,can..mmuno.: snenne seermc "cmonocona ano," as useeren, reerso an anoasas a wc a anoess an anor aarcuar eoe or a comoson o anoesn ccorn,eerm "aum aa snenn secc an anor aarcuar eoe. comosonasas a snn monocona ano" reerso an ano or ano consan reonserverom enn secc an wcas varae an oona uman m umanermnemmunooun seuences.n one emomen, aransenonco ncoonn-au amnano anemsa ar,e e.r.o, aucreanse anc mrouosme,a wavnc ancues a ce oanerom eav canransene an a canransene enome comrsn auman eerm "recomnanuman ano,u"s aes uso anmmoraze ce. a arereare, exresse, cre eeren,ncues auman anoessoaerom an a ae orsoae recomnan means, suc asa anoesmmunoounennems oar ae..,r ao mmoausreearaeserreanrosme,nc o anrraons-ecsrsoomaoesomaorumanransormeo exresse ano, e..,rom aransec rom aos ce recomnan, comnaorauman ano r oma,c anoessoaerom a creae orsoae an oer me ar, an anoesreare, exresse, seuenceso oer se ansanvove scn oumanmmunoounene consan reonsa uzeaurenccuesa.ruucma rnecoemrmnnaenmmumunaon aonuon sees cuoemncersse varae an eermneenes,uncue suseuen rearranemen are encoe exame,urn ano mauraon.sno s an muaons wc occur,or oec. : - ,e varae reownn conne arsee, e..,oner aure encoe varousenesa rearraneo anse anennnoman, wcs aono rearranemen,e orm an ano seccor aoren anen.n ac canesreerre varae reon caneurer moe mue sne amno anooeoren aon ase sno.maec co mnusaano rne oron werm cuaanoennourncerrea resseonese aon an an oene ^ .ae., enscooee sewc c.aner aenoree,ave c reaarnranmmeun aono somuancao meuaeesn nu rcec ac moecues cannoave seuenceen w e orna nucec ac esonseo an anen susanaenca or smar.e.,ave aeas e moecues,unsea we "uman" ano u reerso an an. oer noavn varae reonsn wc seu amewor an reons areerveromumanermnemmunooun erveencesro.murumeramnoreer,mnee amnmuonoo conuann sse au ceonncsesa.n reeon,e consan reon asosncue amno ac resues no encoe um anoesescreeren can muaonsnrouce rano anermnemmunooun seuencese.., vvo.owever,eerm "umman o arn seo-s"e,c asc us meuaeerenens,ss nno vnroen ore soomncauce m aunaoonenn wc seuenceserveromeermne o anoer mammaan sece s mouse,aveeenrae onoumanramewor seuenc s, suc as a "uuman" anoes an are use sn es.eerms "uman" anoes an acs ouse "eumanzeo"m aannso o a r neoner-son uom am ano n au ans. noo anre w recac soem we, mo cs or a oe amno acserveromumanmmunoouns.n one emo orresonn amno ano, some, mos or a oe amno acs ou men o aumanzeorm o an amno acsromumanmmunoouns see omansaveeen reace w more reons a , wereas some, mos or a amno acs wn one or moca re uncane.ma aons,eeons,nserons, susuons or anoarooons o amno acs areermsse ason aseo no aroaee a oe sm ano aarcuar anen. "umanze" ano reans an anenc secc wc an ans o o usee o , orer arne ann n,a aen enermo n ". ne-mormunze" or "e-mmunzaon" reerso arocessn e..,n auman suec.o onereo,s moeo reucesmmunoenc, varae reon seuenr exame,eeav can varae reon ane can eoe "ma" can cesrome orna ano cane anaze an auman ceo come eeneraerom eac reon sowneocaon o eoesn reaon nvuame cnear e-oeeesrmronmne re coens eoes m aan ar oe aenraeze rens orueesr woenne a seeruneancvee. ^ a amernnoa avce sus anuons w seu aenocews r asre oe asenren c aocmvrsn o coemnana anonso. rane o susuons anese seuences are suseuennc o amno ac eocan-secc anoes, or an ororaeno a rane oorreaereamen meossc ennnoronereo,or useneanosc an cane oseeren, wc areeneseoruncon.omeeeav an ane snuess ceomuenrsnasm mosnerou acnenumoa cne rneesonosr areeren coneno exresson vecors anoes areen comaren aroraeoc oucon o woe ano.e varansene.n ano can emca anooca assas, ane oma an oer meosnow ee-mmunze usn meosescreeren or "cmerc annnoe a"r r.eeeres, eo. a.n, anon w orc . rom one seces ane consan r e varae reons areerven wce v eons areerverom anoer seces, suc as an ano erverom aaruamaen a renons areerverom a mouse ano ane consan reons are ncononuc o. escreeones an ano orramen seveerreao ex caamaee e om soecmecnaserennn are aoornrueceaoeeesoac eancoe ceran exame emomens,eonuceoes encoee ano n.n escreerenas caae onn acan comonen orramenereo aa-rnnaen aorreaeeocan, or oeorreaeocan, an eocan.n ceran exame emom aamma-rnnaen aorreae ramenereoescree ens,eonuceoes encoee ano or emomens ren comrsn one or more o :-.n ceran exame more o ,eo:nu-ce.oeescsr eencon sneverae a enxamoe o ermraommenensereeroen co amrse one or onuceoesa encoe aoeeavn a seuence a re enneere :-.escren severa exame emomense ccorno an one o encoe aoeeavn a seue ren are enneereonuceoesa , suc as,oor,,nc,ea,s,-,e,nca,o an, one, o, :- , , ,,eere,onu,ceoeesn cocaono o anmz oeneo o ,, emomens,e enn r exressonn: se-c.cn c seom oer ^ exssureessone.nn s seocmec s emecoesm oern osr,anesm e.noneoerne oomznuceoes coon omzeor esewereeren.e enneereonu aonsescrenurerea escren severa examec eemooesm caenne or or rs. eacncun oren enre c seren are enneereonuceoes :-,,oorom,ose, o a s,euen,ceas- encao an one o ,,,,,,,,,,,,,,,,,,, , encao an one o :-. ,,,,, onuceoes coon omzeor n some emomens,e enneere emomens,e enneereonuceo exesre csosoonn on smezcecor ce exr oerssosnsuen sece.cn s seocme or oransm.oon omzaonsescrenurerea esewer es onuceo eeren.e enneere ne cse craanne or or rs. ramenereoescr exaemeere emn coommrenssn, ae comenrucc aenooes, e ancoumean aen anoo, or or umanze ano.n ceran exame emomens,eonuceoes a orramenereoescreeren comrsn aa, a encoee ano scv, or comnaonsereo.n c a', aa', av, a sne canv e ano orra eran exame emomens,eonuceoes encoe an , an , amnene,r aeo vareasncreereoer,e ann se anece comromnaoenroeureo co.nsns cenr o an , emomens,eonuceoes encoee ano orrame an exame neo an aen,ereormn anmmunoco nereoescreeren onuceoes encoee nuae.n ceran exame emomens,e ramenereo ano orramenescreeren werene ano or n some emomse an ms,onoecoonan aunceooe, os coonaon o seemcezeroomr exr-es,sonn, sec, ocr . ssuee.n some emomens,eonuceoes coon omz ce or seces or oransm.oon omzaon eor exressonn secc onuceoes cane o sescrenurerea esewereeren.e ecors anecorser or rs. onuceoseosersocvrem eees rreenn, a surec v aescorosse eanc coann co anna ann onoe or or morarem oenee erneon oeeree ^ oreesreanvesc coosuuree.no so omnee o erm moorem reenusa, oonre o ere mmoenres o, suce e ansnroeereonuceoess are useunroucnacera,una,eas,an ces, a moers.e vecors cane can exress anorrouce one or mor nma ces, anransenc anmasa e vecors anor veco e anoes orramensereo oeresenscosure. onuceoes r ssems cane use,or exame,o exress one or more oe eren ororounce a a cne,o suces o asr ararmoeuncser ceere,oo.roeru ucsee vsroursaer vecceosrse asncr veec esewere escreeren are aso wne scoe osscosure.nenera, an or ssems seccaon,eerm “vecor” reerso aooa aows oracaeserrouous rom one envronmeno anoer.n some conexs wc we a anser o an en sne ar, “vecor” cane aerm o aro reero a nucrecae ose o ornarransorn anoer nucec aco wcaseenne. veecc ac moecue caae o aasm,ae, or cosm,no wc anoer semen mor cane a recon, suc as aoue recaon oensere semen.enera, a vecoaensere so asorn assocae w rs caae o recaon wen ecoresnrcouer conro eemens. oue-sran e,u are nomeo, nucec ac moecuesa are sne-srane, re e, oraraoue-srane nucec ac moecuesa comrse one or more ane o enesr, v naorereees en osoe.n.,uc cercouaers nnuocwenc ance m aor.ecuneesae o co vmecrosres a “,asm,,” or wo reerso s auc cr acsuar saonuare m sroaneceuar connoo cnsere, ecnnou wes.cno aeronae o veco sresm ae vnras c vaencoe weren vra-erve or seuences areresenne vecororacannor, vruse.. rerovruses, recaoneecve rerovruses, aenovrus a aenovruses, an aeno-assocae vruses s.r es, recaoneecve carre a vrusorranseconno aos c a vecors asoncueonuceoes recaonn aos ceno wce ar e.eran vecors are caae o auonomous orn o recaon an esoma menroucee..,acera vecorsavn aacera mammaan vecors a ammaan vecors.er vecorse.., non-esoma ce, anere are rreneraenoeenome o aos ce uonnrouconnoeos orecne exresesonca oee anoesno w wceeos areen oomerea.veore-ovnere, c.eruacn v veeccoorrss a arree r ceaearree ^ oecenreunes as ar “ee oxresson vecors.”ommon exresson vecors o u n recomnan ecomennnane eorm oasms.^ wonuceoe oenvenxorenssno ano vrmec soursa caenore ex coremssoosne o oe n auc neucce acc acn aoes. c.,e a, wcc c maenanes seaecee r oencomenaasns o exreessoosn c veecsoorsenc usuee oone or more reuaor eemens, neoe nucec ac seuenceoe exre r exresson,as oerave- “oerane” an “oerav sse. n a recomnan exresson vecor, esewereeren e-ne” are usenercaneaeren anurerene e nuc .ne conex o a vecor,eerm “oerane”sneneo meana or exreesosone o seueen ncuec oeoneer seesusencneee..o,ne an renu varoorra enesmcensn a mannera aows aos ce wene vecorsnroucenoeos ronransaon ssem ornenvruses an aeno-assocae v ce.vanaeous vecorsncuearrenarcua ruses, anes o suc vecors can asoe seeceor a res o ces.ese an oer emomens oe vecors an vecor ssems ee-esacsree emomensee e ,ccs aooe rrw rso mmeree aaroecrean ensro.^ uon seu acneo a amnxrersoso coanaees on a a vercoorarooee onrroroucaeroc ce.n some ce or as annermeae vecorneroucon o a vecor no a euaroc cee.., amn aasm asar o a vra veco oenrouceno a euaroc vra-ase or non-vraase.n so racan ssem.e vecors cane vecor an exress one or more nucmece a ecmso, sumcen ass, aorroovareo ae sosur ucsee oo on aem or mo croes o a orevero aos ce oro eroens ecors caneessne oransm.^ os ce.n some e or exresson o an ano orramenereon a suaencue,u are nommoemeon,s,aceer sau caees,oesas ce cess, ansreoca creos,c an ce m.amumaaeano cse cs.es some emomens,e suaeos c n n some emom es a euaroc ce. ^ acera cesncue,uens,e suaeos ces a suaeacera ce.uae scerca co.an sua aree n soransm oe.o co,a acreernaow censnroem areora ecxerreass oon oe v sececoress. ^ n seosemen ecmuoe,mue anres, noemose ceos ar su,ae,nsec, ce.u,aen,sec cesuen,c anueoseroo. ooeraruera.uae srans o.ruera cesncue,u are n m an .n some emomens,eos ces a suaeeas ce.n s ome,o eas ce caneromaccaromces cerevs ome emomens,e mammaan ce.ane ae.n some emomens,eos ces a suae mammaan cesncue,us o ar mea nmomamaen ceo,saveee,nevneesoeeamos eexrrevsasr veceorss.uase mouse meoma ces,ea, , , , ,-,e , -, ,a,am,, , ,a, -, emroroass s.uaeos ces aressceurne ces , an ccen : sseure,rcnaeomecer, eo,a ess,an or exresson. n sonmee e. am ^ soaccmaernosm,cees ve cceroerv csanaeen aceas exresson vecor.xames o vecors .:.-e, auan anersowz, .ueee:ec-a,ar, e a.,cu.z e nneor:,an-eo,,a..s unsveroeerenn, ao "roer a., nvroe aaso exn,resasnon veecoo,r" ra., anc aca conans one or more seuences enc eerso a nucec conan anesre eemensa con on an anoroee an maurer eemensa enaee recaon anr moaneen eaxncrees osone o exreess nuocne vecc aocrnss,e as weeea as an an suaeeas exresson vecors aneauresereo a s ce. varous vecors anecnues ar renownne aror exame, umanaress, eusraenneasroocos,n eon,ao,., e. : e-w.ore,as vec aonrucoz,.. aneeson,.. oecnoo seueronmceo, aenr, a oueornaomousn reecoa ao sns e se ca ueun necn c ecoenan, w orene, o ao nruoemreom se,r a,a suo ecn, r as a a cnenromerocmerase omeraseermnaor, an orn o recaon, mnaor suc as an or oer seecae marers.xames o exr aensso an m vareceorrsenoere u.s.e, aunxoeraos mc,a anncouc, asms,eas arca cromosomes, asms,easneraveas e asms, sue vecors, an esomaasms. ^ ms,eas recave ^ e suaeonr s eoxmere esmsono omeonsn,uceeo veceosr ans aoracurovrus vecor or exresson vecor an can eu suraeos ces annse oensnnsec ces.n some emomens, cu c ce.acuovrus vecors avaaeor exresson oroensn -ense acn cesee.., ser ceessunccuowe aneucm semreersm, e a.,.o.e.o.: recomnaneno s, .roo :-. r ooeraruera-assocnaseec c veras,r voewcnorns s aerreum-rereeera susenrsoonuc cennsec ces, e.., ces caneurcaserom commerca uure.erum-reensec n some emomens,e v veencoorrs,s e. a., mammarc - .^ emomens,e mammaan exr maan exresson vecor.n some onuceoes an esson vecors caae o exressn one or more vec oroeesn a mammaan ce.xames o mammaan exresson auormsann,c eu ae,.,u a.re nom.eo, ee, .aure: an or more suae reuaor eem:ens- caa.e oe m caomnmroaann e exxreressssoonn ve ocor cean onnec oure m oone onuceoes anorroensne mammaan ce.or exame, co re areerveromooma, aenovrus, come mmon useromoers eren. a ^nnownne ar. aovrus, sman vrus, an oersscose eren oreea on suae reuaor eemens areescre esewere euaroc ceors o seee,r e s.u.,aea exersress aonn vec oorsa amnro voec,o er s a.s,emsororoaroc a:n aoraorress,orn.nar e.,o rnaroraoraor,o rnaror recn exnre ssosmoen e omoe nmucenesc,or ace, re. rceo.m, erennan.^ mammaan exresson vecors caae o reuaor eemens are us an aarcuar ceee..,ssue-secc nownne ar.on-meno e exxamresess oe s nuucaece acssue.-ssescue-csercomco reersunacor eemens are romoerver-seccner, e a., .enesev.:-,muee aumn romoersaame anaon, .v.mmuno.:-,narcuaro-secc ce receorsnoo anamore,. .:- anmmunoouromnoers o e a., .e:- ueen anamore, .e:-, neurosn-saencec, ^ ro:moer-se..,,ean ncerueraos-samecencrorommooeerrrne anue,.roc.a.ca.c. mamm sun, e a., .cence:-, an uroeaarnan-seccromoerse.., m weromoer..a.o.,, an encoma caonucaono.,.eveomena-reuaeromoers are aso e sse, e..,e murneoxromoersesse anruss,.cence:- ano αe-seeororoenromoerames an man, .enesev.:-. rears o wc areanrcoorco arnae euar reoercen vceecoerrse, mnennoenrs en maree o..e.r eamenom,en,s can, ue czonens vecors, w rearso wc menons mae o..aen acaon ,,e coe vra o wc arencororae reerenceerenner enre.ssue-sec nens arenownne ar anns rear, menons mae o.. c reuaor eemens wc arencororae reerenceerenner enre aen,,,e conens o eemen cane oeraneo one or mor .n some emomens, a reuaor scosure so asorve exress e oe enneereonuceoes oeresen scosure.^ on oe oe enneereonuceoes oeresen s n some emomens,e vecor cane auson vecor oruson exresson vecor.n aosmoe eme amonmoeenrms,nuusso,n ca vrecoxorse arm anu nsu,m orero o a om an roec aocso aroen encoeeren, suc can serve one or moreuroses, mnanroen.ucuson vecorsncreasee so suc as:oncrease exresson o recomnanroen o recomnanrouen a ocne a recomnanroen an o aneurcaon oe oonuceoessu s aann anurcaon.n some emomens, exresson oxuns c as non-cononuceoes anroensnroaroes cane carre e cerca co w vecors conann consuve ornuceromoersrecne ereusssoonn e oxr eesseornu vseconor o cra nnonn-cuusoen aoroenouceoc ceeasv anorroens.n some emomens,uncon oeuson vecoracone or oer ae se, wc canenrouce ae orroeno enae searaon oe r uson moe ane recomnanonuceoe acone or oerus ecomnanonuceoe orroenromeuson vecor uc enzme on moe suseuenourcaon oeusononuceoe orroen. eneronase.s,x aanmeeurs coon enxaeres rescoonn vecoonrs sencueuncees,ncuearmacacoraao,ecromncnm an ^ anaromancsoan,, .ene:-, ewnanoas,ever,ass. an roen, oscaawa,..auseuaone-ranserase , maose nnnuce nronr-ouesnon,. c reose ecxvreess,ono veceorsarnceu reecomrcnanmranrone en a..xames o suae an ue , ene:- ,caerm e a., : e-ree cress,aneo,a. -.^ eresennec s scoomr a osen u eremo son exmu rec ene ssso e,eeoxrneuscseoone encon an ano orramenereo o ssem.n oer rom a vecor or suaeonuceoen a ce-reen vro vroranscro wnorranss,aeono snsuecmeso ane a canroerraanesc vreceors an are oenonaransaen vro.n commerca avaae.enera,n vroransc eranownne ar an erocesses o anroen s ron ann vroransaon ssems recae ecors an s ness, resecve, ouse oe ceuar envronmen. re uaeonuceoesorn vroranscron canncue,,,romoerranuscarore seeuoencneusceoa ceane reconze an ace uon an aroraeomeraseo n vroransa oro vnec coar. ^ oronuceoe ornecoune san-aonee..,ransaon o aure vroransa eoranscron.n some emomens,e ce-reeorn e exracs coann snsceume ca vnarnocusu mea ecxrormacosecruomar r caomo rencuoces, weaerm, anor. co. exoenous e.., or rosomes ensa are neeeorransaon o eonaonacors,ermnao , s, amnoac- , sneases,naon, eransa nacors, ec..er comonens canencue or aeurn en on reacon,ncunu nomeo, amno acs, ener sources , , sserems reenoesraoneno ssermuvsaec arneaneruvaoesnaaese aonra ccreearane sseomsonaseeuaroc ,, ec..srevous menone,n vroran s, an oer co-acors sarn maera.omeransaon ssems can saon canease on or recuocesaes an weaer uze an emae as sarn maerae..,emae as a sarn ma m exracs.omeransaon ssems can uze aransaon are coue anerae.s.,rs coran-scarsee snsoems.,n wecse ss ssuemsesureannscrranosna aen. ^ coumameerc saana ar an coue ce-reeransaon ssems areeneranownne ar an are ecoreaurvaae.^ oe vecor,ees veecoros cnauncnecouee aoeonaeveeareure,s a var cuasn caorncere onero oru mceoreuenconaes oee exresseereo.uceauresncue,u are n rerom, or seecae marers, moecuarener omeo, reuaor eemens, e. we areca se.., moecuararcoes, sazn eemens, ane aonaeaurese ose sene araeesn oe exresson vecor anransor ncue caneen on sucacors ase coce oeos ceoe euamore,eeeve o exressonesre, ec.^ escreenre cm nee crn aas nnnc emueo onmee onrs m,oree re enuanoerere eemeonsnucaeo canese o aneraorv vecorsereo onuceoe.eerm “reuaor eemen”sneneoncuereneoenerna rosoma enr ses , oer exres omoers, enancers,ermnaon snas, suc a son conro eemense..,ranscronocazaon snas soaenaon snas ano- seuences an ceuar or exame,ne.., nucearocazaon snas.uc reuaor eemens areescre, osearec cons,oe ucvae ee, emxcressreosns, oa an nuceeoo,ea se. .euao:r eemensncue osearec exresson oe nuceoe s uencen manes oos ce an secc reuaor seu euence onn ceranos cese..,ssue- e ences. ssue-seccromoer canrec exressonrmarn a asncrreeass,su oer oarnceureasr, c seuc ases mues.c.e,, nemuron,one, sn,oo, secc oranse..,ver, exressonn aemora-e oces.euaor eemens ma asorec sae enen manner, suc asn a ce-cceeenen oreveomena emo-emeennse,n a v mecanonre cro,m wrcses m oane o orr m moare noo asoroemosesrue or ce-e secc.n some romoers, one or moreoromoerse e..,,,,,, or moreo oromoerse. ..,,,,,, or moreoromoers, one or more oo romoers.,nc,u,e,,,u, a orer m nooremoeroo,moe arsn, or comromnoaerosn.sxearmeo.es oxamoes ^ oromoonearsn wcue,eu are e nnoanmcere,oe, ceo rmeerovaroavruosus sarcomaro vmrouseroo romoer enancersee, e..,os na we ro ar e a,e,:- ,e romoer,e r oae reucaseromoer,e-acnromoer,eosoceronase enomanoceerr, e aenmense, sucα asromoer.so en enacnocmersassee-’ seeemrmen “rneuaor eemen” are e.o.,o.,.-, enancer anenron seuenc oeewee-n eo. an o ra -onroc.a.ca. xons n some emom c..,o. ,. -, . ^n ens,e reuaor seuence cane a reuaor seuenceescre o...a.o.,,,e, co..a.u.o. , annernaonaaenucaon n some emomens,e vnecenors c oan w cocna anre an mconrmoraaeromo reeer.rennce someree enmner enre. mnmaromoerseecromoer, romoer, or.n aur omens,e mnmaromoers er emomen,e o exresss asueo sneucc.^ ransaonanaon reuaorce soeuee,ncees v,e ec.o.,r caronmnoceurs,e onae orre mcoreeranscrona anor ene anorransaon oe encoeroenn a ce.n s ranscron oe romoer mae emoe.uae consuve ome emomens a consuve nownne ar anncue, romoersor mammaan ces areenera .uae consuveromuo aerers noomeo , , ,-α,-acn,, an nroomwonenrore e axr,re ssuscon asn aea-romoerraocreraace creas, exearesss ceons, an an anu ancao coese arereoneernaase romoer" rene srosmoe emomenss., ^e reuaor eemen cane a reuaeromoer. "euae anor saa-reuraomeoe mrsannaer, arnecnecnue eexsressssueo-ns neoc cocn,sssuuev-er,un aemora- romoers.euaeromoersncue cononaro eerre annuce emomens, cononaromo moers annuceromoers.n some a secc ce e, uner ceraenrs en cavnronem emenao ceonoornesc, a enxroerssounrn o a a soecnucce soaee on erovmeooemrsene...uae,ssue seccromoe,rs cannc,u ane,u are no,anmcreeaco, ceverro smeocercs ^ e..-v,,,cxn,,x,, car,acc saecccromoerse.. aa , , ,,, , ,, x, cenraea ner,v souns c sese sme ceromoers e..,, ,mmune ce seccromoers,e.. , rcomcoromoers romoer, romoer, romoer, uroena ce seccromoers er, ,er, enoea ce seccromoerse.. ,uroen an eme..sn, , ce seccromoerse..c, ,necc,racur,,ronc,ermaer, romoers, a arnee mnuesrcae cenow snecnce arrom anoe arree w..nesme snco.e oersssusec aonsuor ce secc e.. aromoneurcae acconvaesonraanscrromooenr os caenoenuocseovee unounc aerconroen.a ^romoers an acvae acvaor, or annucercomoun, oraeneracon w neavecononanuc envronmena conon, or oer smuus or a reressor une reressor ceonromoon oeree..,ro amoroormos reermovaese r.e.,rensseucere.n.,soun a ounoeromoer smuan reease oeromoer e rer a reressor cemca reressorromeromoer envro essor or remova o a envronmena conon, or o nmen.enucer cane a comoun, resonsveo an er smuus.us,nucecononaromoers caneemeraure,, an suoare. sumuae suncuc as ceceomncao,naooromcoa,er osrn ocuere, muoe acreu nar aens,o,e-n,e-,acromoer,a,c,ex,sromoer,s romoeome ex, , r,awn, ace uner ceorner eox an oress aonann a.^ romanoe cre,.es., aesrre,e enneereonuceoes cane erenes oromoerss envsae omoer oeraenan ces.e use oo exresse oen rea . consuveanromoers aromoeras ae urn a or near aevnrame a conrosn a or near a oeanssues ne non-mn examee oo am coennsau saveesr oomoeerasnere caeurreowoe ars m "coosansc vuruve exresson". erenromoers marece exresson o aenenere s romoer. eren saes oeveomen, orn resonse nssues or cees, or a emomens, one or more oe enneereoonuceereon eensv arreon emxernesase co unneorns.e cnonarrocu oa ar ^ coronmsouersve canromeo uer,ze sucoa arsee en caaunceow exerre msosac vrus romoerssue-reerre anssue,ornsance vasc sonn ceran cees wn aarcuar oa uar cesneaves or roos orn secc ces oe see.xames awarmcauaa er aro.,moersoran useeor exsreosson: o-e enanmeearmeooo en au.c,eoesa anreoun:n- aanrae e e a a.,, aannoooo::-,user e a, anoo:-, an oene enxam oreesn oe exrormesoseorns maa a ursee an - ourc.^ m oe a ennera. can aowor saoemora conros nomeo soun ener, eecromanec eorm o ener mancueu xames onuce sse raaon, cemca ener anorerma ener. moecue msncueeraccnenuceromoerse-n ore-, sma ssemswoo-crorme,ranscromoann asc, ovra cronsoc srsoemmes, suc as, a, encu.c, oreranscnrucoe ecor arec canesnranscrona acvn a seuence-sec na comonens o a nuce ssem mancue an enneer c manner.e scosure a -resonsve cocromeee eonuceoe oeresenranscrona acvaonre romere..romraossaana, an a more oenuce renssnonroomeanns.nro svomee emnnoermnaenosn,aea veencoru cancancouneo o.ne or wcescre an e.., emoaenmenus ocanouncoes., n , , , e aaeor use weresennven nroens an meos o use an can or examen, s comeem ecma-oremueanes,rarnosmeonon o o. rsr ^ ,n.eu.,ce exresson cane aceve ncun, cemcanucesene exresso were e acaon o an exoenousncun a cemca- n.ouaon oene exresson can asoe oane exresson.emca-renruecsseerroommooeersr, wnceuree, auca areon no ome ceemoc,ae reressesene romoer, acvae enzene suonameerce saener mazen- e so:-,e ma seeer e a., an rooc ze romoer --, , acvae romoern eoe ecr ao.,c comoousncs uoseec ansore-eomceermen:er-ce asc, avnaeeo saacccoc a-c a. ^ rerormesoserse wromco aerres reauza ee a., anoocs,e snucen aseraccne-nuce aneraccne- an,, c e:-..aenos.,, more eemenn sso cman ae a a emso eoe om us raee nnsso,ere caen.^ no annucoreo exer, vecor or ssemereo canncue one or secc ce comonen or essn an enneereonuceoeon a rosome, enoasmc rec ouruamne,eo.uc a oarraanues,e cs coarnonacue,u are nomeo, nuceus, coseeon,asma memrane, ce wa,eroxsome, cenrso, mes,o ecc.onucra, r veacuuaoe,sosome, canncue,u are nomeo, nucearocaza or eemensnreaerea esewere on snasexames o wc areescre see e..,:enome.unmecr.eenu, aonc suc as anoseea e a are., annoa.eaanasee.oc:avaaaose . acraaese easvewer,e nuecreeanr e,x : oerses enoro sasnmasc ree.c.,uumocazaonree : an :, , , , an oersescre esewnereone srenase.., e..,u e a. o.o.e. :- anoreu e a., ..no. ane smee : - , moconrasee e.., . oe eeors.:-,arcuar a. aous ece a. e a...o , e:-unes eca a-...o.em.:- e a.,..o.em.: - cox e ao.,sso e. a.,.::- aner aans e a., . e :-,eroxs - - - - - .uaeromee.. - - , , ene usn an suaeaa oenaren mos can asoeesne or ner :mnmomnaesre orreconoo,ncunu nomeonmo .emomen.oname=roen.or,,ocs:eem aoomven,er.mrsc-mreuc.caomr.a,c.uarreeea-se.- e:www.cs.u.servces:warwew.c,s.u.oros :www.cs.u.servcesoro s:ur.v ervcese , reoar eecaeaerrsearse asn.nraa.rreoar, anna :www.cs.u.servcesna.^ oerwse mone oer moornec os uee a eonnnuecereeooenauc eneocoeess o crans ae se oeceraae manreer, orusae, wo,c or ^ caonee aeo seneuccaeoe mear orer coaneenceo.ronra soemen eme eonmneenerse,oenouceeoee encon a seecae mareroee, wenransae,snsereeweenw sucae - an-ermnus oe ano orramenereo oe o amno acseweene -ermnus oe ano orramene resenscosure or ae- anor e seecae mare reo oeresenscosure.n some emomens, wer a orraes aonuceoearcoe or unue moecuarener . ^ canenc caeaeonuceoe encon suc seecae marers oras ramenoreroeorae oneo aresoennucsceoosuree ennco ann a ornoer oare m moraen cnoemronens oe ano or seecae marer ora.ucecnues an meo o aow exresson oensan arecae one o orna s areescre esewereeren an we seecae marers anas a r sne arn vew osscosure.an suc osscosure reeneranownne ar an areneneoe wne scoe as cnnuna. ^ero seeencae m, maraeorsse annansnrcoueen,u are, nouamoene-o,- arannserasaes, suc, coromasoraa souas szaonas suc asoreoxn ano , , an eoeas su uc asose conssn ooanonc amno acs, suc as -a enzmac mocc as-a,c-a,-a an-aroenasa can aow secc reacon aonsuc asonaon onase or cemca mocaonsuc as resrco wn enzmes o-r oero enrzumoeres cceeanvcaeem saens, se anmeonrsa s eencmoenesroauc cosnaan sroevcneom recssn,an acme acann,sa onamerwcsne,eoxraccc conme,ouanssa, nnecoun anocs, suc as, ,romcnosoranserase aneem acnnorosoranserase encoeroucsa are oerwseacnne recen cee.. semensa marers anor semensa encoeroucs wc, enes, auxoroc enoc marers suc as-aacosase, uor cane rea enee.., roen , can ,eow , re escenroens suc asreenuorescen onuceoesa canenerae ,ucerase, an ce suraceroenswo seuences norevous oneux ora moosree n,ewrm seeru senecseso nro acee. u.,one oru axcaeos uoonn o ^ a resr-c aonn enso-naucse,a asne o,r oer seuen mcoesan m eanze am me,o ceecmuacra,a ercco. eeoease.., ener , seuences reureor a secc mocao or unue moecuar aowssencaon.er suae marers we arecae ne.., meaona eecae marers anas cane oeraneo one oro mse o sne ar. ^ -as ssemescreeren va suaener, suc a ore comonens oe as s acne orcne serneners su saore asner or uo3: or3:.er es v areecoers ocrr veeco ers sewseemre ceren.^ morearen mo anncue one or moreonuceoes encon one or en ees.n some emomens,earen moe encononuceoes can exrecssuee wnne an vecoror on or veec vorrus ssaermc,e suscr aosu ac vera su vcecora sseem v,r sucae areareeo secc ces,ssues, orans, ec.n som usarces cane onuceoes canencuene vece emomens,earen moe encon onuceoes anorroucs e or or vecor ssem sucae enneereareeo secc ces, xresseereromncueearen moe an canearen moe cane asascuees, ooranes, c earcr.ern seo.m.,e eommoerm,ens,, suncor aas non-vra carrers,e cane caae oarene carrer an an aace or nc moecue ec. an anor anoes orramensereo assocae enneereonuceoes ec oeresenscosureo secc ces,ssues, orans, o.^onmsaescorn oe eosewnucereeoereesn anecoronuceoes anoes orramen ,e enneereonuceoes encon one or more emomen sereo oeresenscosure cane coon omze.n some escreesr,e onnea or ar meonre aoonnucoeo an oeso connaan ceoonn o a vemczoer e“nvecnoeerreonuceoes” encon an ano orramenereo oeresenscosure c onuceoe enera, coon omzaon reerso arocess o ane coon omze.n exressonneos ces on mon a nucec ac seuenceor enance aou,,,,, eres reacn aeas one coone.., aou or morean morereuen or m,os,re,uen, u,s oer mnoree coenoenss o oae noasv cee se wuenec mea wna cnononse naa avree ^ a ammnnoo a acc. seouoennce.asarouersen sceecsens c eoxon usaarecueawreenasor ceran coons o aarcuar ecenc oransaon o messener m oransms oen correaes we on, amon oerns,eroeres oe coo, wcsnurneeveoeeenen arcuarranser moecues.erensomenransae ane avaa o enera a reecon oe coons use mosre nance o seece sn a ces caneaoreor omaene exress uennee sness.ccorn,enes oon usaeaes are re onn aven oransmase on coon omzaon. a www.azusa.orcoona an avaeseaae,eosr c eaxname aea, aeen “ a noumoners oae waas.aaesee”a avaamaurae ., e a. “oon usaeauaeromenernaona seuenceaaases: , earc”uc.cses.: .o sausore ar muer aormsor coon omzn a aueanr seacuoenucse,or e,x arere asssoon avan aaaer.cnu saormeos em ceo arme aso avaae, suc aseneore ,,,,,,,, or more, or a co ens, one or more coonse..,,, asroen corresonsoe mosr onsn a seuence encon a -aren usaeneas, r euen use coonor aarcuar amno ac.so coon :www.easeerences maeoe onneeasenomeaaase avaae a e enome.orcommuncoon_usae.sm, oroon seeconneas,ncnunenzen a anae, reae,oem. ar :-.so coon usaenans ame anowrr,encaens maseoo.oona unsaen:–e.r asans,reen aae, an canoacera, urr we asoon usaenanenes, coraoa es a an, cucaeccses. an :- oreecon one coonas o r : neeenesnerenan an aaneaes,oron,ovo. e,ssue- ve.^coronuceoe cane coon omzeor exressonn a secc ce- seu ee, orane, anor suece.n some emomens, a coon omze or eexncreessso an senu aencuem oan omrzeumaonr e cxere,s osronorn an ao euearoe, e..,umans.e.,en omze a mamma or avan asses r euaroe, suc as anoer anmae.., e am oe o cre esewereeren.uc coon omze seuences are wn eonuceoersn caoro sn oem arzesanorn a v sewec oc ceeescre.uocn ceeren.ens s coamnen ecmuoe,muen arse, ^ n ooermoeowo o, eranse, nae crvees censcunernves s,rna cne cse, cse, ssnnan coeasronesnarac, cesnn asroces,a ces,cwann c umn ces, nerve suor cese.., a es ec. , musce cese.., carac musce, smoo musce ces, cnes s,eeneaon m cuescs,e c caersa,e co cnenesc,veoossu cee cse, ssema c aens o aner sossuean ces,one ssem ces,erm ces, an comnaons oerroenor ces,mmune e am oe ornar se ars ereo.uc coon omze seuences are wn eonuceoes c ann vew oeescroneren.n some emomens, are nom oon omzeor a seccssuee.ucssuees canncue,u ssue.uce cooo,n m ouscmezessu see, cuoennnceecs avree wssuen, coenn aecvessue, nervousssue, an eea oeescroneren.n some emome m oe ornar se arsann vew secc oran.uc oransncue ns,eonuceoes coon omzeor a ran,uns, somac,ear,nes,,ua area noer,manecreoa,s, muasceesr,, snr,on,esonnee,s,ovoer, v seen, oo, an comnaonsereo.uc coon omze seuences esses, ornar se arsa are wne am oe n sonn vew oeescroneren.^ arcuar ces, smuce e amsoromarenos,c a o vre ecuoraroocnu cceeso.ees e cuoaorno oc cmezeor exressonn erverom aarcuar oransm, suc as aan or a s maeose o or uman, or non-uman euaroe or anma mamma,ncunu nomeo o,vesoc or mamma asscusseeren, e.., mouse, ra, ra, ecoronsr, or non-uman mamma orrmae.^ ecnue.n seuc om veo ecn eomrsoemscernse, oneer oern mo craen suea coen rsercuocmena usonn an anor s cuoaerocess orecnues cane useoe vecorsescreeren.uae r nn meos orecnues anor meos canncue,u nome ecomnaon anor conn ucaono. .er suae meoo,so asneeesccrneuesn..aen esewereeren.^ areescrencun.o.nsaru.coo.n, o re,comnraanscn e a vecors areescren a numer oucaons, e a.,o.e.o.:- erm.,onao.eu.zcoz.a,:-:-rascn, ^ a unssecu aa ssnmu eos ers a ea ae.,.or croon.sru:cn a-n or o.ern vec ooreeseccrneueesre ann. nor me voecso crasn aree resrcon enew n soonmer ucee e eamere seon.^ recmoens, a vecor comrses one or morenseron ses, suc as a emomens, non seuenceaso reerreo as a “conn se”.n some , one or morenseron sese.., aou or morean aou,,,,,,,,, eem oern mso ore onnese orr monor se veesco arrse.ocaeen m uusreaem anereonruowensream o one or more seuence exresson consruc mae useoare n onuceoes are use, a sne corresonnare seuences wn ucec ac-aren acvo mueeren, morean aou,, a ce.or exame, a sne vecor ma comrse aou or emomens, aou or,,,,,,,,,, or moreue sonuceoes.n some onuceoe-conann morean aou,,,,,,,,,, or more sucue- raecor vecors maerove, an oonaevereo a ce. ^ useerenns n somse co enmexo remeernsso,oe vnecucoreos ae v-raase vec veocr.orseaer cmon oa anr o “nver oar vecor” an as rom orase uon one or more eemens o a vrusa ca more eemens acan aonuceoe, suc as an enneereon ne caae o exressn an vrusarce anroucn sa vrusar uceoe oeresennvenon,no a vecorssuc asn a vra ce wen use aone or w one or more oer vra roucn vraarcesor veecovrer s ose amn.or erxare vsescoonrs o an one s osr memosre anereoo ceasn orer uasemeor ereoescreeren.e vra vecor canear o a vra vecor ssem ns vecors.n some emomens, ssemsncororan mue vr nvovn mue oese ssems.uae vra vecors ca a vecors canncreasee sae vecors, aenovr nncue rerovra-ase vecors,envra-ase vecors,r aae-noavsera ve vcecorosr,s a,eenroe asss somcaeex v vercuos-rs,asee vere-ceorse,nen aenovra ansen-arr vrus-ase vecors.er em oxvrus-ase vecors, rouceererom areescre es omens o vra vecors an vraarces conureorouce recaonncoemweereene vreran.anr scomeseo ermmoromveen ssa,ee o vrae vseec sosrsem arse.^ ^ usn vra veec sess.emns aanrc cuomar eomsoonsm oense,rees ceonmosscoosnusre a mnaeevereoan cesnean ces usn aan vra vecore.., as ssems maenrouce oao. :-.uc vra vecor mesacree an vecoo e a. ,nnuev emnvruse.., caaeea cur vrus, corrom a vrus, e.., cur vrus, ma eaneowwar vrus, weawar vrus,omaoea e..,aaeazne n secreroac vreus,owo vacrucos.eae cu vrra vr vues, oromaooen mosac vrus or nanovrusoravruse..,oacco rae vrus,oacco mosacco vrr muas,eo aex vvecruosrreo.m., anoao v vrurus, e.., orevruse..,are sre mosac vrus.e recanenom s, or non-nerav es oan vruses mae e a ee voecso arns.^ecnuesor vrusrouconrom vra vecors areeneranownn on-r.^ra ar “on-vrnec a s voo emrs ceo er”m ano amsens,e vecors a non-vra vecor or vecor ssem.eerm o a ar useerenns conex reerso moecues anor comosons excuen vec anors nuuceoae areo noeeasveere on a onneo orr e mxorreess comonen o a vrus or vrusenome caae oncororane enneereo e e non-vra vecora cane onuceoeso a ce anor ex nuceoes anevern sa enneere asoes no excue vec ressneonuceoene ce. we arecae onuceoe ors conann aonuceoeesneoare a vrus-ase aeonuceoaseoeevere. ^ eren canne snocmuee ems no amens one or more enneereonuceoesescre esewere eren reersoonuceo naeseao aren nuoce aossoce.aee werm a ono arer “ mnaoeecuoeen.u.c,eoe” as use anor oer moecuesa can oeneroec rom envr roens,s, eraaon.s useeren, assocae wncu onmenaacors anor asoreo, encosen, encos es,us nomeo,neo, aereo, ancue one or more en or wn, mxe w, anee.aeonuceoes reco aos ce an o oonea en enxeerreesseoenruecne.oees naeescroenuecreeon ceasn caeneavvee arne ^ suoanuecewoo-e asn canreee s-nmee-nssroannae co mnoecuuraeso,nso.ue w sraan oe n mono-ecmn exames, nae e..,asms an arca cromosomes, moe ues, crcuar moecues srane anoronsa areoue sranecuesa conanoronsa are sne emomens,e naeonuceoe conane.., rozmes, anee.n some resennvenon.n some emomens, s one enneereonuceoes oe anoronuceoesn ao e naeonuceoe can conan oer nucec acs e naeonuceoes canoe enneereonuceoes oeresennvenon. an nncue one or more eemens o aransoson ssem.ransosons on- ssreamsoereo areescrenreaerea esewereeren. ^ n a non-vran son omucee nu eo cmeooemec e venor ecss,o or.neu ora moer neo on-vera enoneereonuceoes canencue meo,ransoson vecors an ve nuceoe vecorsncue,u are no arca cromo cor ssems,asms,acera arca cromosomes,eas covaen coseso vmeceso,rse.a.n mnoccrc reess,s mannceve-creoers, masmnnsos an,n meanr coasvmas, crcuar vecors“ume sae”, mnmascmmunoocaeneeneen exre cose vecors, mcro-near vecor vecors,nsrns, mn-nron sson os-sereaona n ssems, oeraor reressorracasms, ssems ee e..,aree e onasms, anee. n some a e.mo.meenness.:. ^ orn o recaon. ,e non-vraonuceoe vecor canave a conona asm.n so n some emomens,e non-vraonuceoe vecor cane anmmunoocamee emneomeennes e,xreess noonn-.vnra somoen eumceoomeen vse,core c naonn-varvae ao mnnumcasc vecor canave one or moreos-sereaona n ssemenes.n eoe non-vraonuceoe vecors-ree.n some em some emomens,e vecors a mnvecor.n some emom omens,e non-vraonuceoe nucearocazaon sna ens,e non-vraonuceoe vecorncues a one or more mos..nn so smomee em emoommenens,s,ee no nno-nv-vraraoonnuucceoeoee v veeccoorsr c caannncue one or more scaomarx aacmen reons s.ee e..,rovc e ncue :-,on e a..v.ene.:-, woseecnues an v aec.ors c.anee. ^ a saaae ororan uszeanon oe crersoemnosnovmeensonr.ou s areoo-rasce a seacuemnceensoaea nuc ae raore mane s are oenoun coseo reuaor eemens suc asromoers, ena rx. recaon.ncuson o one or s canacae a once- ncers, an orns o manane non-vraonuceoe vecor as an er-ce-cce recaono emomens,e seuencesocaeow enssormenauer ces.n ceran onuceoee.., one or more -as ssemoneam o an acveranscrencuene non-vraonuceoe vecor.n uceoes oeresennvenon romeea-nereronene cuser.ee e. some emomens,e cane a :e u e a..c.naec.:-.,erne ese a e. a..:.u-ceccoraaes. a..v.x.e.o.:- anesen e a. e :-, woseecnue .eneer.o.o. n some emomes an vecors cane aaeor useneresennvenon.^ useeren, “ransoson”asnos, reeer nreon-vor aas vreacnosrossa arean esemoseonn ve recoerrs or ssemereo.s seuenceas caae o movnormocaonn aenomeo ano o aonuceoe oransosons.ransosonsncue r er.ere are severa casses reureeran eroransosons an ransosons.eroransosons eonuscron oeonuceoeas moveorransosen oreroransose reure revceresoereanosc ar neown oenomee oornoucneuoceoeea.s morvaensoosronrsan asreoseosena oroer noransoseeonuceoeo a newenome oronuceoe.n some emom o vraonuceoe vecor cane a reroransoson vecor ens,e non- reroransoson vecorncuesonermna re .n some emomens,e vecoroes noncueon eas.n some emomens,e reroransoson vecor cane a ransoesromnn vaec reor.eas.n sroamnse eomsono vemceonrss, cane nnocnu-vera aoonnuucceeooe seuence encon aransosase.n some emomens,eransoson e non-auonomousransoson vecor, mean vecors conure as a ons own.n some oes naeransosonoes no occur sonaneous seue e emomens,eransoson vecoracs one or moreonuceoe auononmceosus enrcaonsnosonr voeecnosrs raecu orene oro mrorreansco esemoenn.s.^n some emomens,e non- ^ arsonunc soeome eem vecoormeans co an noann-svrae enonneuecreeooenransoson vecor ssem canncue ane one’ an’ ensransosone uceoes oeresennvenon onuceoe vecorancues a rmnanvere reeas s an a secon aromoerorve exresson oeorannsucoseaose.e caeaneo o a erneco exnres aserannsosea ssaem coeu ceoransosase cane exresserome secon vecor an canr ee s oners vecore..,e enneereo ansosee maeraeweeneneraeno one or moreoso nuceoes oeresennvenon anransoson vecor nsneos ce’senome.n some emomense s cane con ourr seseomanere ao sr coann se cocne acucreeo ars s aeenoeorwae.n so am ree eomreomens,e enee.., one or more oe enneereonuceoes r anor oer o a.enransoson occurs we u oeresennvenon an a sron cannserno annron o aene anenseres rneoresr v oerc oore orr sensee cmanreorveoo,e ae mrsa-nssocson rocess an as a resun acv n n suaeransaeseraeene. ^ cann oson ssem cane use.uaeransoson an ssemsereo see e.c.u,ve,c ws e aou.m.aeon.,ee:n-eau,ransoson ssemcmarner sueram a. : ac ac sueramsee e.., e sueram ,ro-rncec anmarunsear s eue ar.am. . : - ,o ces. : see e..,se e a. ucec norouc- an varansereo.^ rouce ane a mno e-n oenoowncann aen aroorese a snnreasms oen asnoereoes,osrc exoasemee,ren c ceane sness or recomnan exressonecnues.e meosesc mca oerwsencae, convenonaecnuesn reeren emo, uness anass, recomnan , oranc moecuaroo, mcrooo,enec mocaon, nucec a cemsr,ocemsr,, oonuceoe sness anecnues areescrec rzaon, an reaees wne s oe ar.ese era ,or exame,ne reerences ceeren an areu exanene rnure.areoer, e.a.,oraaonrasress e aam.,roo eo ae.c,uar,onno:ecuaraooranonr:anauao,raoor ^ aoneucau,econ on,o rnaroraoraorressamroo e a., aroraronn:aoraoranua,ornaroraoraorress,orn an ann,uusue e a.,urrenroocosnoecuaroo,oneons uaesaa ueaesurrenroocosnmmunoo,one ons an annua e. .onuceoes aonuceoeness:racca roac, resscsen es. enomenass:nnaoues:racca roac, ressrren e a., n some emomens,aoraoranua,ornaroraoraorress. e.., recomnan an ano orramenereoescreerens an ano creaon, e.., va s anneoss,erneeacre en, enxeerersnse o, creae s,e oruesnoceas.en c an meansanvoves ano orramenereo comrses seuenc eran emomens, suc ao no naura exs w ese.., seuences or amno ac seuences umann vvo.^ ne anoermne reerore o an anma or mammae.., eecve amouson, aenscroreeaser eenec areve amaromuanc,eu ancaororemuaonsa can conan an amoun, more comouns, moecues, c raeuca eecve amoun o one or ereowc are aso reerreomo aosseonsr,m veacror asc, vveec aoren s osremns,re ceesn, o erse aw coemnaon escrenreaerea esewereeren an aarmaceuca reeren n some emomens,earmaceuca acceae carrer or excen. oeresenscosure as armar or secoornmuara aocn cvoem aernse.s asn u asneoere on, “raamrmenaceuereco ormuaon” reersoe comnaon o an acve aen, comoun, o a armaceuca acceae carrer or excen, mane co rnreen w a eraeuc, orrevenve usen vro,n moson suaeoranosc, acceae carrer vvo, or ex vvo.s useeren, “armaceuca armaceucaor omru eaxconena” reserseneora a ca srraeer, o nron e-xcoxce,n anass ne useeurnoorearn a oerwse unesrae, anncues a carrer or excenas a ca or we asumanarmaceuca use. “ar cceaeor veernar use asne seccaon an camsncuesoma ocneue acna m aocrceeaane on cear sruecr o cra erxrcer oern e”x acs uesne. ^ aermnacreeusen,e comoun can oonaeresennearmaceucaormuaon as a sa oe acnca svoem a nec ec rme eoa enme s .eans us.,see aecrevne, “nraermeanceuscreasen ac acse aarmaceuca acceae orase aon sa wose couner-ons are non-oxcoe ae sa” reerso an acnarmaceucaoses oe sas.uae sasncue, sureco wce are amnsere osae,sonconae,acae, sacae, ac crae,orome,oe, nrae,suae, arrae, ascorae, succnae, maea arrae, oeae,annae,anoenae, ormae,enzo e,ensnae,umarae,uconae,ucaronae, saccarae,ouenesuonae,ae c,amuoarmsuaeo,na me,e naanesaueonnesaue,on eaea,nesruooonnaaee,, meanzoennaees,u monaanee,- maae,aae, ae, neeereo ve a a ananrm suacaem auoa ecae. meoromu oar roounseeos acr sueecernen ne ceaneer amnsereo a suecn roues canncue,u are nomeo aurcuaroc,ucca eo.uae amnsraon eecro-osmoss, enocervca, enosn , conuncva, cuaneous,ena, exracororea,emoa usa, enoracea, enera, eura, exra-amnoc, arera,nra-ar ss,nraon,nersa,nra-aomna,nra-amnoc,nra-nracaua,nraccauvaerr,nonusr,anraarca,vnarra,rnonrcaceare,rna,ranurrascas,enrnraac,arnrac,nracaranous, ena,nracoronar,nracororus cavernos acornea,nracoronanrauoena,nraura,nraeerma,n um,nraerma,nrasca,nrauca,nraesona,nraumna,nra raesoaea,nraasrc,nranva,nraea,nraocuar,nraovara mac,nrameuar,nramennea,nramuscuar,nraumonar,nrn,nraercara,nraeronea,nraeura,nrarosac,nra asna,nrasna,nrasnova,nraennous,nraescuar,nraeca,nraveonroaucsc,onursa,unuraavr,enonursaurmo,r,nnrarvaenmrcaunacr,,nnrraauveerne,nravascuar,nravenous,rraon,arnea, nasa, nasoasrc, occu sca,nravrea,onooress, oroarnea, oer,arenera,ercuane sveressnecnue, oamc, ora, reca, resraornaao ous,erarcuar,erura,erneura,eroona, sucuaneous, sun n, rerouar, sossue, suaracno, suconuncva,ransracea,ransmuaan,c s,u umreuecroasa,, ureorcaa,, anranosre vrmaan,ara ansmmnucsorsaa,on,ran asnaocren ana, ^ croemaen aanonor oe aove amnsraon roues, wc caeens oneseaseoe ces, or an coemree a n acv are oon nrare ere,e cnoms.ouns, moecues, comosons, vecors, vecor ssems, suecn neeer eoescrenreaerea esewereeren caneroveo a ormuaon.s suceo, a asso anenscrreeen ar,e sucar amsa acne auccvaeonrmreuaenon osr c aonena,n aarmaceuca e comouns an sasereo, orarmaceuca acce nn one or more o uae sasncue,rorome,oe, nrae,sae sasereoescreeren. sacae, ac crae,arrae, oea uae,osae,sonconae,acae, maeae,e e,annae,anoenae,arrae, ascorae, succnae, meanesunonsanea,e, euamnaersaue,onauec,onaeen,zenuecsauroonnaae, saccarae,ormae,enzoae,uamae, naaenesuonae,roona e,-ouenesuonae, camorsuonae, n some emomene,s m,aonae, maneae, maae,aae, anamoae. sease anor.uror e suecn neeereoas ors susece oavn ame an susa ernecon, or a smomereo.s useeren, “aen” reerso c uannucen ace,o coomcoaun an, moorecuseo, aoncae eeec, w on ac su caneceo wooccas a acmvnes orer oeerow.ses wsecesreno,o “accave a acenv”e o orr o “acervwesne,rneuecnes” a reeorsooc aa susance, comoun, or moecue,o wcs amnsereo.n oer wors, “acve a orsooca eec on a suec comonen or comonens o a com en” or “acvenreen” reerso a comosons arue.n aen coasnoen ao wrce woe orar oe eec oe comonens o a comosono wce womar acve aen, orn oer wors,e arue.n aen cane a seconar aen,e orar oe eec oe comosons comosono wc an aonaar anor o orn oer wors,e comonens o a armaceucacceaearrers anecoer eec oe comosons arue. earmaceucaormuaon cannncuare anrearmeancesu anens uaearmaceuca acceae carrersncue, ca acceae carrer. acoos,um arac, veeae os,en u are nomeo waer, sa souons, suc asacose, amose or sarc, manezsu amc soeaoras,e,oace, secnce acc,o vss,coeuasna,ra carno,erruamees ^ oe,eearous ac reac es wers,e arcoxve c meceuose, anovn rroone, wco no earmaceucaormomoson. suc asurcans,reservaves, suaaoznerss c,a wneen ser aeznes,, a enmuseesrrse, s,a mxe w aens, osmocressure,uers, coorn,avorn a sornuencn noeeerous reac we nor aromac susances, anee wco amoun o snec soonmear em acovem aen ac esn,ve se comarmouance.ucaormuaon can asoncue an eecvencun,u nomeo ,ncunu nomeo,ooc aens or moecues aam , e..,onuceoes, amno acs,ees,oees, anoes, anaeesrsc,s, roz anmess,asmoromocnse,s,m amnu-nnomaomumaors, anrecs, anxocs, anscocs, cemoeraeucs, a aores, an-samnes, an-necves, convenonan so umsee en om a reonm coemns,naeon sesconereaor. acve aen canncue one or more aens n some eamesease or a smom or seconar cononereo. onuceoes, amnmo aocms,enes,ees s,ecoonear aecs,v aen aeoness, o arnacmuerse,s r,us nomeo,mmunomouaors, anrecs, anxoc ozmes,ormones,nammaores s, anscocs, anaescs, ansasmocs, an- ereo.^ , an-samnes, an-necves,roases, cemoeraeucs, an comnaons nn s coemrae enm emoomemnesn,s,e seconar acve aens orncues an an-necve.^ seccroase. e seconar acve aens orncues aeocan- nn c ceerraann e emmoommeennss,,ee s seeccoonnaarr a accvvee a aeennss o orrnncues an anaesc. n some emomens,e seconar acve a cues an an-rec. eocan-se en comrses an an-necve an a n sccroase. roase, an aonm-en emecomens,e seconar acve aen comrses, aeocan-secc n some eve, an an anaesc. roase, an an-nmecove,m aenn asn,aees secc,o annar an a acnv-e areenc. comrses, aeocan-secc ^ cne soomaxem eme, aozomcenns,,een acn-nn,e ecrvero amencns, o crenrcauxoense,oxccne, amoxcn, ceuroxme, ereo, or an or an acveervave or anaoue xem comnaonereo. xemaarre anorecan-seccroasesncue an amase or asozme.nammaorese..,uroecsncue,u are nomeo, non-seroa an- sacaese.., c n, naroxen,eoroen, an nmesue, asrn an reae araceamoaceaone sacae, manesum sacae, an soum sacae, xemmarno anean,e meamzoe, naumeone,enazone, anunne. nonseroa an-nammanosrcessen.c.u,e,uruoe anr,e n naoroxmen,eeoo,roaerna,c aenam nomaecseuamen,oen-, oxncoonoer,ser.o.c,o rooneec,ox,r coemeocroxn,e, ane eonrec,oxure,no orones,era.m.a moor, nne, coene, urne, neoam, orenarne,reaan,aaenn, ccoen orenerne, meaone,eoemone,rrame, an asrn an rea zarne, scooamne, manesum sacae, an soum sacae. e sacaese.., cone sacae, annecouss a uesne anereorn m, “oanu-anee ocrnve” reesrs acov com,nouencsv or, m reoeccuaeosn, aan caonr e ser sucasnecvs reuce or emnae anoresease or smomereorean assocaesess severe or emnae.n-necvesncue,u are no as anaceras, anunas, anvras, an anroozoas.ua meo, anocs, nomeo, amecese.., nazoxane,ar e an-necvesncue,u are coroune, meosne, amoercn, a omomcn, meronazoe,nazoe,oramcn,enamcn, ama noouno, amnocosese..,aromomcn, meenazoe,ver cn,anamcn, an neomcn, anemncse..,rane, e.., azoe anunmaescen.,.,rarzacounaanzeo,e, auecnonaazzooee,,oasaceonnaazzooee,, oexamnune, anunas mconazoe, an vorconazoe, ecnoca oconazoe, cormazoe, rseouvn,ernane, nnse.., casounn, anuaunn, an mcaunn, anmaara aens uec.osne, anoenese.., nsan, an amoercn, aovauonerouan, ., rmeamnesuaoxne, aremeerumeanrne, rmeamne, anaouannnren,e, anroxucercouroosusne a,e mnesoe.u.,ne a,m cnoosarocunaee,seo.x.,c acmnneo, ^ s eaacmcuo a,c r,amsonn,az raruamn, rn,aseonnnaez, carraezomnamcn,e arnam ccn,oseernaeu, anne,vrasosnaz, amanane, rmanane, aaca e.., c vramvune, emrcaneenoovr, aoacsaeveravremrcaneenoovr, eavrenzemrcaneenoovr, emcracvraanmevounnaevzrrovounavner,enoovr,amnveurenreonz aovau-vner,avrn, emerncearenroenen aoaovr, maravroc, raeravr,oueravr, enuvre,oscarne,omvrse -, nevrane, eavrenz, eravrne, rvrne, n, oseamvr, zanamvr, aeovr, soosuvr,ano eavrne, nevrane, enecavr,amvune, zacane,e sne,enoovr, aacavr, zovune, savune, emrcane, arunavr, ronavvur,ner,an samver, areavzar,navocr,e nerevnra,ver,a amrevrern,avonavrronavr,osamrenavr, vaaccovr, accovr,amccovr,an r,nnavr, saunavr, ravrn, orenem, meroenem, e ccovr, an vaanccovr, caraenemse.., cerane, ceazon, ceraaeenxenm,, c aene cmaes,a cenamroennee,mo,ra ccearaeo,s coeronseaen.,., ce ceuaroxrox, ceroz,oracare, ceoxn, ceacor, ceuen, ceraxone, ce me, cenr, cexme, ceoren, cezoxme, an ceazme oaxme, ceooxme, vancomcn,aavancn, oravancn, aneavanc ,coee anocse..,erosacse.., coazmne anaome,nconm,ccccnese..,eccne, cnamcn anncomcn, macroes anervaven anervavesereoe.., axomcn, erromcn, azromcn, carromcnsereoe..,,eromcn, nezo, suameoxazoermeorm, raxmn,rromcn, anroeanomcn, meronazoe, azreonam,acracn,encn , coramenco,osomcn, carencn, eracn,carcn, amoxscamnocxacn, amcn,acamcn, eracnazoacam, cavuanaecarcn,enc vuanae, amcnsuacam, coxacn, an nacn,unoonese..,omeo n,rocaneencn, oxacn, crooxacn,evooxacn, xacn, noroxacn, ooxacn, moxoxacn, reaoxacn emoxacn, moxoxacn, cnoxacn, naxc ac, enoxacn, suameox,aoxacn,rovaoxacn, an saroxacn, suonamese.., oxccne,azoeemercmoecconrem,, mn soucacsanaez,neo,xc ancne susaacsoxaczo ace,,oexraccccnneesomeea.-., ^ moeuennsaamurnae,eosaom accn,s c,n aonxacenr,accne, an urnar an-necvese.., nrouranon, ecvem naxc ac,rmeorm, an meeneue. secon no suonmse emomens,e amoun oermar acve aen anor oona eecvaer am aoeunn. casn usee aner eene,c “eveec amvoeun am,ouenas eecve amoun, anoreraeuca reersoe amoun, concenraon, ec. oermar”, “ aeneocr ove coonnace snecraononar”, a anenornceenearmaceucaormuaona aceve one or moreerae ue s useeren, “eas eecve”, “ea uc eecs oresre eec. eowes amoun, concenraon, ec.s o eeecrvmea cron acnenorra oon”o,n aan seocronee amoun reerso e one or moreeraeuc or oeresre ee ar aena aceves amoun”, “eraeuc cs.s useeren, “eraeuca eecve concenraon, ec. oaerm earec avneo cro oncenonraa soenc”on anaro arenencuee reenrsoe amoun, ormuaona aceves one or moreeraeuc earmaceuca eraeuc eecs a eecs.n some emomens,e one or more sease, or a s reorea orrevennecon w.urorer,rea orrevenme oermarem a eneocm ovee on ar ameoo su. en,eas eecve amoun, anoreraeuca eecve amoun arm conar acve aenescre esewereeren conanene ,,aceu,ca,o,rmu,aon, can,e an, no,n-zer,o am,oun rannrom aouo,,,, ,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,, ,,,,,,, n,, m, or ore a ,,,,, or, , n somn numerca vaue or surane wn an oese ranes. ^ e e emomens,e eecve amoun,eas eecve amoun, anor anraoreuecraaeu ecaecv ee aemcovuen c coanncee an eecve concenraon,eas eecve concenraon, rom ao nraon, wc can eace an non-zero amoun rann ,,u,o,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ^ ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,, ,,,,,,,, ,,, ,,,,,,,,,,,, wn an oese,, or, , n,, m, or ore an numerca vaue or surane eraeucan o eeecr ran v eemes. amo ^ oumnen os,eerm earec avne o amoun,eas eecve amoun, anor zero am ona seconar acve aene an non- ,o,un ra,nnrom aouo,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,, ,,,,, ,,,,,, ,,,,,,,,, ,,,,,,,,,,,, or,,, or,e an,,,,,,, wn an oese ran numerca vaue or suranenearmna scoemuec emeos.^mens,ermar anore oona seconar acve aenresen .,.,.,a.orm,u.ao,n. can,e. an, n.on-z,ero. a,mo.un, r.annrom aouo., .,.,.,.,.,.,.,.,.,. ,.,.,.,.,., .,.,.,.,.,.,. ,.,.,.,.,.,.,.,., .,.,.,. ,.,.,.,.,.,.,.,.,.,.,., . ,.,.,.,.,.,.,.,.,.,.,.,.,.,., .,,..,,..,,..,,..,,..,,..,,..,,..,,..,,..,,..,,..,.,.,.,.,., .,o,,,,,,,,,,,,,,,, ,.,.,.,.,., ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,.,.,.,,.,, nu.m,erca., vau.e, or s.u,r or. ww, vv, or wv oearmaceucaormuaon ore an ormuaonne s.o.m, aes e ama rone mam w ren ansn w an ore orre o s aec coeese n oar ra r cnees. acvo^ e auaenon,se ereseecnven ameounar oma cceeus ccaan ^ a cse e a an somu am ,xoun x17c raen cesnmsm,ro ,xm a x2o c8ue csem or sm, cxes ,x3o ce9x csem1c sm,exsm ,4c,e1x200sm, cexsm5ce ors11mmor,e, sxuc6x12cesm,x13cesm,x14ces15x cesm16,x cesm17, cesm,x18cesm,x19cesm,oom,x20cesm,x cesm,x or surane w n an o es r aoux cesm, or an numerca vaue arcesenn somee evmereoem.ee .n r , asa,n vrees us a.maorunce or eecve amoun,arcuar were annecve e eecve amoun o vrusarces cane exarvesnse aes armearr oar sueecoonrmarn a uenns ase ar c uanro o, voe aumoeu or as aarcmesuerc, n o,ne,c mo,n o.rn soome em20oamrecness,eer e,e ncv,e am, moun can orx mo11r,e,x suc12, asx ao13u,xx114,,xx125,,xx31,6x41,7x5,18x6,19x7,x8,x209,x, or10,rearnsor,m nn, un,s mer, or, n.,n, s mome, o emo,xmen2s0,,xe e,excve,oeorr a caonuex aouarces1or m11ore, suc12as a1o3ux114,x2,15rx3o,1x4,xran5s,orxmn6, uxns7,erx8,, nx,9,, mx,1o0r,rxanso,rmxn un,sxer,x, n,,x, m,, orx o6r, anx nu17m,erxca1v8,auex or19s,uoraonre a wounxe20ranes.n some emomens,e o e armaceucaormuaon se .o or more, suc as.,.,.,.,.,.,. can ranerom aou .,.,,.,.,.,.,.,.,.,. ,.,.,,.,.,.,.,.,.,., .,.,.,.,.,.,.,., ,.,,.,.,.,.,.,.,.,.,.,,., .,.,.,.,.,,. ,.,.,.,.,.,.,.,.,.,,.,.,.,., .,.,,.,. ,.,.,.,.,.,.,.,.,,.,.,.,.,.,.,., w nese ,.,.,.,.,.,.,., , or more or an numerca vaue or surane aens esn ra cr snome ees. eemreon cmonenas,e amoun or eecve amoun o e one or more o e acve o aou m asnene armaceucaormuaon can ranerom aou owe o e seccae uoneowe o e suecn nee ereo or averae amnsere.^ enouaono wc e armaceucaormuaon cane ^ ormuaon,n eme eoecmevnes am woeurne oerees s aec soencoanrar ac aveen conanenearmaceuca seconare aren,ermar aen,e amn aen w vareenn one amon o sraon roue, suec ae,sease, sae osease, enn os, wonac wreseen onne oe ornar sne ar.^ canenc armaceucaormuaon,e seconar acve aen armaceuucaeonrmueaonarmaace cuancae aomrmnusaeoren o cr can exs as a san-aone comoun or comoun,ervaveere onemoraneous or seuena we n some emoom,e onrsarmaceucaormuaonereo. ^ oonaresen,s an non-zero, ameou ene rcanven amrooumn a ooueo sec,on,a,r, ac,v,e, aen, wen ,,,,,,,,,,,,,,, ,,,, ,,,,,,,, ,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, vv,, or, wv, o,e,oa, ac,ve, a,ens,re.se,n.n,e.,arm.a,ceu.,ca.o,rm.,,.,, or,., w,w,, vaue or surane wnese ranes. uaon or an numerca seconar acve a n aona emomens,e eecve amoun oe ,,,,,en,s, an, non,-ze,ro a,mou,n r,an,n,rom, a,ou,o,,,,,,,,,, ,,,,,,,,,,, ,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,.,.,. ,,, ww, vv ,.,.,.,.,., or. ese ran, oer wv oeoaarmaceucaormuaon or an numerca vaue or surane wn osaeors.^ roven anms soosmaee eomrmo.meenoss,aeeormar cmanaceeu acmanosremreuaoo ans sueesccrneeren cane osaeorm cane eecveenerae secc con neeereo.e a aven se cenraon, suc as an eecve concenraon, reeroscanes scureeec unns ne seuaeereoor. uses unse aeren, “ose,” “unose,” or “osae” can uan oermar acve aen, an oona sureseecn, s eeaccon unar c aocnavennnr aereene,e arnmonre a ^ assaorcmaaceoun wcaormsu aamonnsreareoon. canc suoamee emooromuceens,eeesreve resonse or resonsesn amnsraon se.n some emomens,even sessaon sesroxmaoe cases,eosaeorm conans areaer am e amnsraon se.n somenearmaceucaormu oun o one or more oe acvenreensresen orocaon wne aonanenanene amoun neeeo reac a secc reon seconass m sueco accounoross oe acve comonens suc as vars an rorae roeea ueoo ssasm nce. uoer,msu c aarne noe amaeeoo,r or aamnncsuranonucca an or s aurorae roue.nraocuar,nae,nranasa,ocancunucca, sun nua, reca, arenera, sucuaneous,nramusc ua, orranserma, vana, arorae roues uar,nravenous,nernasa, annraerma. er meonow areescre esewereeren.ucormuaons canereare an casues,eon esan s oee ro a arrm. es ^ s, aaoweerso orr orraan auems,n sosuraoonns, canscreeosae uns suc as aueousus eeoams or ws, or or susensonsn aueous or non- emusons.n some emom n o-n-waeru emusons or waer-n-ou asoncue ens,earmaceucaormuaons aaeor ora amnsraon ormuaon. oneos oar meoorerm asenres warecorav oorar, aremsernvse,r caooonr, c oarne asserseearmaceuca souona caneevere as aoam, sra, oru souon.oeneorm o au amnsereo a suecn neeereo.ere arora e oraosaeorm cane cane mcroen e,eosaeormsescreerennreen.neca somossuaaeeo.^rm can asoereareoroon or susane reease o an ces, or a comnae eomnoeremoeness,c cromeouenresn, m caoneceuese, cnomreoseno wns, vecors, vecor ssems, some emomensermar acve aensenreen ose reeaseseae.n emomens, an oona seconar aen c wose reeaseseae.n some meosoreane reease o aaneenreen wose reeaseseae.uae emenenreensn maerannnreenncue,u are nomeo, coan or ormuaons canereare asescreonm searns,a wrax r,eeeres,n acnes suec ase. "eaarmeac reeueacsaeoossaaee ^ socremncea aens,"r eacs.ce oermaanrm ea.c a".,ew eo.,r,anrcceoeear,msnc., n,s ",emanmoorne, -e , an "armaceucaosaeorms anruever ssems", on,ns , ea,: ams an ns, .ese reerencesrovenormaon one e a., maeras, eumen, anrocessesorrearnaes an excens, orms oaes anees, casues, a casues aneae reeaseosae aou anouro aou nranues.eeae reease cane anwererom omers suxcam aess c o m e suuon osas ee or ac c m eoaor aene. ^ maaeraae,sncuroxe,ruo are c neomeo, ceuose meceuose,roxro meceuoseaae, an roxuroose, roxro aceae succnaeovn aceae aae, acrc acomer meceuose meacrc resnsa are commerca avaae un s an coomers, an arma,esersa,erman, zen, seac, anosererae name onsoueooamenrs,s an maoreoermeneen wo amers,er wena o rcac r woar oes ou w. ^ waaere-rsonuseomer, waer non-omerc excen,orouceeesre reease ouewaer soue oneosaeormmarx or sme wcnc roe.e coans eererorme w or wou coaeeas, casues ues,us nomeo,aescomresse comosons, ^ "nreen ass"o w or wou coaeeas,eas,arce osaeorm. rmuae as,u nomeo, susensonorm or as a srne emomens,errem aarr aocrvaee,nreeeonsase, aonrmosr oescornae seceornenar ca ancve aosome.nese armaceuca acceae saereo were arorae enreens, anor emomens wereeosaeorms ao arencororaeno aosome.n osomaormuaon.eos some,earmaceucaormuaonsus a osaeor omaormuaon cane amnsereo a suecn neeereo. ^ creams, susensons,omson as,aoeweorsr, sooucaon as,mansessr,aeons, c sanrase, aormuae as onmens, emomensorreamens oe ee or oer erosos, or os.n some earmaceucaormu exernassues,or examee mou ore sn, an onmen, armara aocnsve aren areeen a,s a ooocnaa o snecmoennar or c arecamve.nerneoernm,ua aneonr ^ waaremr-amcesuccae o anccmeenaeas sea.ner oeoer w eemreo amroenrsa,e ceanremoarrmu anaeor w se aaranc ornreen caneormuaen a cream w an o-n-waer crea conar acve osaeorms aaeoroca amnsraonne m mase or a waer-n-oase. mou wase ouncueozenes,ases, an susensonos. rosa ^ seorms aaeor nasa ornaaon amnsraonncue aerosos, souons, oona s ,es, orrowers.n some emomens, armar acvenreen, a econar acvenreen, anorarmaceuca acceae saereo weres oroarnaee o cran oeanna aeosa mecorromo anzaaeon.onr snomaea emonosnm aenas,rcee-sarzec-ree suceorma reucee.., mcronze comoun or sa or sovaeereo,s ze oe sze .o aou mcrons as measure an arorae meoneowne a vaue o aou aaeor amnsraonnaaon asoncuearceussnne ar.osaeorms werene carrer or excens auor amnsr or mss.uaeosaeorms aueous or o souonssusensons aon as a nasa sra orrosncue maeenerae varouse o an acvermar anor seconarnreen, wcnsuaors.e s o meereoseressurze aerosos, neuzers, or n s nasanaaonormuaons cane amnsereo a suecn neeereo. ^ amnsraonomen eamaoon.mnen sos,me oeoessaee emoormsme anres, aereos aoerosoormourmauoanson su coanaeor souon orne susenson o armar acvenreen, seconar acv ns a armaceuca acceae saereo were arorae an aaenreen, anor aueous or non-aueous soven.erosoorm rmaceuca acceae uanesn sereormn a seae uaons caneresenen sne or mu-ose conaners a sneose conaner.or some oese emomens,e seae e.., me or mu-ose nasa or an aerososensere w a meern vave een exaeursee.osenaer, wcsneneorsosa oncee conens oe conanerave conans a suaer ^eeroe aeeraonso unoesrareessourrme, ssuc con asanen an aerososenser,esenser roean,ncunu nomeo a comresse ar, caronoxe, or an orancn oer emomens are conanen aumro-auoormoczaerr.on.eere asesruorsozeo armerousaooonrmousaaeonor cmans ^ ansore coenna,n an a sooruoanrm orac ae suuscaenso acnc oe aarem saar aecrevoe.nnreurene, oona seconar acve ormuaon aso conans co-sovens anor m r emomens,e aeroso sa anorase anornearceoersncororaeomrove,or exame,e ormuaon.mnsraon oe a mass caracerscsamoun anorroe oe or exame,,, orm erosoormuaon cane oncea or severamesa, aerosoormuao esa,n wc,, or moreoses areevere eacme.e or sonmse canosae aemonrmsser seuao ae suecn neeereo. ^ armaceucaormuaons arowern anor aaeornae amnsraon,e aen, oona seconar acvenr aae-ormuaon.n aono armar acve arorae, suc aos een, anorarmaceuca acceae saereo were ma aeorm can conan aowerase suc asacose,ucose,reaose,nnrenoen,, an anoorr sarcarm.ance suomcea o acecsee eameo samenesr,e ao wrmearre a acrover aen, seconar acve reuceorm.nurer emomens, aerormance m aesn aarce-sze amno ac, ceoose ocaaceae, ano oer, suc as-eucne or anoer cacum searae.n so r meas sas o searc ac, suc as manesum or o me emomens,e aerosoormuaons are arrane soa eac meere osee o co ameroosos coonns,a cnosm aoruenes,er vmecnoers am, mouonec oue asn, a ccevenreen, suc ase one or more eren. ^ s, an comnaonsereoescreamons, creoasmas,eeosr,msas aeas,eor vana amnsraon caneresene asessares, amnescrano nnnc oams, or sraormuaons.osaeorms aaeor reca a su ue suosores or enemas.e vanaormuaons cane amnsereoncue aueooe useas aeer noe orom. rs ^ no an-aaueeouosr searreneenraec aomnn sosuraon anor aaeornecon can uers,acerosas, souesa rene ons, wc can conan anoxans, an aueous an non-aueous sere comosonsoonc weoo oe suec, cenn aens.eosa re susensons, wc canncue susenn aens an sne-unose o eorms aaeorarenera amnsraon caneresenen a vas.eoses carn mue-uonozese c aonna ren-seurss,ennceunn a suer noe camrreeroo re sceoanes aumeoueesos oer ^ sormore eom aomnmsenras,onro.mx seemreoraonweoeurss,nreacon souons an susensons canerearen e amnsereo a su nues, anaes.eareneraormuaons can acve aen,o sre scoomnea erme aoc cvmn ee nnee nsr,eeere enoosa. ^eorm conans areeermne amoun o armar aroraeer unos , anorarmaceuca acceae saereo were seconar acvenreee.n,n a ann eomroarmmaecne,uceare aceceermanee sa amouenreo o wremrar acve aen, e an eecve amoun, aeas eec amoun, anor e arorae can emomens,ereeermne am aeraeuca eecve amoun.n oer armaceuca acceae saeoreuon w o aerer amarro arcavee, a canen,e s aenco anarro arcaever aaceno, anor eecve amoun oe acvenr n oe o-eraes anomnaoneeen.^ a comnanon somreea emmeno omre cnoms,nera aonarmesaecraeu.caeor cmoumanoansoescreeren arear o armaceucaormuaonescreeren an nreamen canncueereamen moa cane a cemoer an aonareamen moa.e aona mouaon, envro aeuc, aoocaeraeuc, surer, raaon,e eecrca s nmena mouaon orera, asca acv mouaon, acuuncure, nm suoameo enm,scaera, an an comnaonereo. o,onuceoes, amonmoe ancs,s,e ceo-eersa, oor coemneas,on aneroaes,nc auaem,eurs,s r noozmmees, anormsoansems,ocsm,m aunno-mnoamumaoaros,res, an an-rescasm,ne asn,xocs, anscocs, anaescs, comnaon an-necves, cemoeraeucs, an ecve.xns soemreo.^ n e emomens,e co-era or comnaoneras orncues an an- eocanem n- csera ecarn an c em-noec roamseevness, areee cscor-eeranr oera ceormeana eosneweerraeeresn o.^rncues a anaesc.nn c ceerraann em emoommenen.s,e co-era or comnaoneras orncues an rec.n some emomens,s,e ceo c-o-eraera or o cro cmomnanaononerearass o orrnnccuueess a ann a ann-- ^ cnomecnvaeo ann aeraeso ornccanu-sesec aceoroacsaen.-snec somce emrooasemens,e co-era or anaesc.n some emomens,e co- , an an-necve, an an eocan-seccroase, a era or comnaoneras orncues a emomens,e co-era or comn anna-onnecervae, annc aunaese asnc a,n ano an o arnr-amreenc.enr some eresenscosure an an eo o n some emom aenns-necve ceuroxm ,e an-necve aen comrsesoxccne, amoxcn, ereo.^e, ceoaxme, azocn,encn, erromcn, ceraxone, or an comnaon eocann so smeec ecmomroenasse,.exemearocean-soeccacnroroasaess aacera cemuram--aanne amasesroses,-aceucos esncue- muramases.ee aso, e..,ome amnases, an-ace--- ose e a.,roc.a.ca.cr. e. a..,. ,cro,o.ev. , ,- an eeocan-seccroasencues an am -.n some emoemns, uae anrecsncue,u are nomasee or ao, nsoonz-me.^ e..,uroen, naroxen,eoroe seroa an-nammaores cone sacae n, an nmesue, asrn an reae sacaese.., meamzoe, naum, meoanneesum sacae, an soum sacae,araceamoaceamnoen, uae an,enazone, anunne. nonseroa an-namamaenscosresnceu..e,,uuro aeren, n naoroxmen,eeoo,roaraceamoaceamnoen, norse.., roecox, ceecox, an eor en, an nmesue, - oxcoone,rocoone, rom cox, oose.. morne, coene, urne, neoam, orenarneo,rrenea,aen,nea,auernenno,r cnceo,ernamzaaron,e n,or seconoerne, meaone,eoemone,rrame, an asrn an reae sa amne, manesum sacae, an soum saca caese.., cone sacae, mnsraon oearmaceucae. earmaceucaor ormuaons amnsere o muaons orosaeormsereoescreeren cane ,,,,ne o,r m,ore,me,so,ur,, ora mor,e momnes,o ourre,arae,. m.o,n,,,, or,e,ar,.,n, s,ome, ^ e ammonsmeernes, conenuoarumsac oeuverca aeorrmou oaonmse o rranosnaeroomrmsereoescreeren cane anosaesorms arenownne ar an mnuesooursoas.evces connuous amnsraon oear escreerena are eecveorove emomens,ers on maceucaormuaonsescreeren.n some suseuenose e or aewna amouns amnsere cane aerosean manenanceosse., ressecsve.can so rmeeer ermeoomnense, are asar amaocaeuncaoosrem ouraoosnes an a amnsere sucaeoses overme areaerencrease or s cane wean a suecraua o o aarmaceuca ecrease overme so aso earmaceucaormuaon. ormuaon orrauanrouce a sueco amoun o asrmreavro aucsve asceunss,e se,conearar amcacveeu acean,o arnmuoaron can conan areeermne ereo were arorae.n some oese em armaceuca acceae sa aroraeracon oe eecv omens,ereeermne amoun cane an e amnsere o e amoun oe acvenreen.uc unoses maereore era, mon, ornceear or. muocreaanrm oancceeu acaa,o mrmonua, oornse maare.e.,re,a,r,,,, or moremes wenownne ar.^ e an oe meos suec,eeerreen co-eeraraeess or oro mrmuearmaceucaormuaons areoeevereo a euena amnsraons amnsruaaonon ws cearne aen a amrnecsaeree a smeouuenn oam oer s ocmcuursaneeowusee. amnsraons, suc as morean aou,,,, mnues or more.em n amnsraonsn seuena amnsraon cane one orer oo eeween ears,eenn one acve aenresenn urs,as, mons, or even reerso amnsraon o eac amnsraon.muaneous amnsraon mee.., wn secons owrous or a meowre mornmuuesa aoanrs a, weer seameenmeen ors suasaneaorm auaeon same amnsereoeer ae sameme.^ se conan one oersc mroree conm exoaumnse emomenseren ares, suc as comnaons,a escreeren.s useere,n c,omeoesrmosns ",coomrmunaaoonns,"ev ocre "s,or oerarorsm" rnee ars meooe ^ c aorem usoeunos, c coomecos samons,es,or smourea saomns,esa,r sces, samevceess,, aens s an aona comonensa ever, anor amnser an eemen, comna ames,acae, se, mare, acvenreen, conaneere on o eemens or a sne eemen, suc ase acan,c srnes,seran.uc aona comonensncue,u are nomeo, vas, coe caes,oes, souons,eecon reaens, swas, coecon o seccano snomu nee es nm,a aoe oms a rren enas,e eee. eo comcarnsesa aoe annucoeo oer ernacomenneere ano coaae ramenereoc a vecor comrsneonuceoe a ce orouaon comr or e ano orramenereo,onuceoe, vecor, or an comnaoneresn armaceucaormuaon comrsne ano orramenereo,onuceoe a ce orouaonereo, or an comnaonereo, an aarma oe, vecor, or an comnaon oa-e.n some emomens, ceuca acceae carrer ano orramenereos caae o seccanenorsre aaoeeocano wce ae,orreaarn,orreaaonca,orrea an rreaurorer,orrea orreaur,orreaanu,orrea erson,orreasse,orrea snca, orrea mamoo, anor vaasana,orreausanae,orrea seman, oerwse conn saonmee enm ao a anmenor esr m,ea eeum coonmesa o exnrareoe sno son ascoann.cuesnsruconsrne on or rearne conen oe comouns, c .ensrucons canrovenormaon conanene, saeno omosons,ormuaons,arces, anorevces ormuaons,ar rmaon rearne conen oe comouns, comosons,ncaonsor use,c aens,o arn reocromemvecnese corneaamneenn remeensnoorrmae coonm reoaurnsn, comeoossaes, ormuaons,arces, anorevces conanene.n some emom ons, canrovereconsor amnsern or oerwse usn ens,ensrucons ormuaons,arces, anevcesescree e comouns, comosons, ereo.n some emomens,e s ren or a comnaonereoo a suecn nee monorn, san, anorr uecn neeereosn nee oanosn,ronosn,neconreerre eanmesease anor aorreasease anororreae sease anororreoaeerennec aso an “so arreorareenaecuron”or.ern, soomrere ema aoeme,nso,rreeaoarrrena, ^ aonrure,aaorroencaa v,aaorsreanaa, anoerrrseona,usoarrneaasse,orrea snca,orreaur,orrea aorreaonesarsease anornecon.e,orrea seman,orrea mamoo, anor uanneosrcrreeaene ceroan ecxaanm, ane eomroanmoesnns aeren are meos oeecn anor anormeseasen a suecn n orreaenecon,orreasease, eren.n some em ee, usne anoes orramensereoescre conac omens,e meo oeecn,uann, anoranosn comrses su ne ano orramenereoescreeren w aooca samerom a saecn nee aneecn anoruanne amoun oorreaeeocanneremane. an su soemce w emo onem oern mso,e meo oeecn anoranosnurer comrses escren ce reeraeuc aens. eocansease or srmano emxamereeo em, aoomrreenaseenreenc aoren m ore soms oomreaerneo a, aorreae sease, anormesease or smomereon a suecn ne orrea reucn,nn, or ameoran one or more sm e, as we as meos o a suecn nee, usne anoes o oms ome anororreaseasen emomens,eorrease rramensereoescreeren.n some ae,orreaarn,orreaasae aonncoar,oorrrreeaae anneercsoonn,s aorroerraeasseur,oroer,orrea orreaur,orreaanu,orrea vaasana,or rrea snca, orrea mamoo, anor aorrea reausanae,orrea seman, anosc caon onesarsease anornecon. ncunscmoesesesren are meos oanosn aorreasease, e..,meseasenammaor cononeasen-r ae saueecan noeeoese,reo e. c.,om arrsrns, co nneuarcono acna asorer, anor aen, e.., an ano orramenereo oeresensco n-eocan orreaeeocan w aooca same oe suescure aa seccanso a orreaeeocanne same.n some emome n measurneeve o orreaurorer,orrea ae,orrea ns,eorreaeeocans a orreasse,orrea snca,orreaur,aronrre,aorarneua,aoornrecaa, voararesaan aan,eorrsroena, ^ suosmean emae,oomrreenas, s a meemaon, oorarenoas mnamomoe, asneasoer an ao srureeaonesareocan.n conacn an ano aans an an-eocan an cn neeereo comrses aooca same oe suec an measurneeveo o.e., an-oc ano w same. an-eocan anone esewereerseon,socroseanoesrenn a are coomosons, suc as an ooseescrenreaerea ncun mese rreasease ororreaenecon, suc asmeseasena ase-reaeaooes, e.., arrs, neuroocasorer, anor emevmea oor a cnonooensnrcecuees a ana ansenoorr mreeaaseurneeoevcean o.no sroremeae emeomocan or orreaeeocans aorreaurorer,orrea ae,orrea ens,eaonca,orrea anerson,orreasse,orrea s arn,orrea orrea vaasana,orreausan nca,orreaur,orreaanu, orreaonesareo ae,orrea seman,orrea mamoo, anor a anen-nnr can.on-mn exames o suc aensncue anoes, or rece aansamensereo,a seccanoorreaeeocan or anoes anen-anoenonrre coaueee usoeoca mn.eansu sroemee emevoe omenosr,re anae assaeao canca mne oarsureeve o anoesrece aanseorreaeeocan.on-mn exames oe assasncueuraceasmonesonance,anaro annemmu sucmmuno-, an - . ona assasa cane use wenoresoeecnues,ncue coormerc assa,asu cromaora, an mass nscosure n some emomens,eeve oorreaeeo seccaromerecnues.ncrease aeas aou, aeas aou , aeas aou ,nn aooca sames aou , aeas aou , aeas aou , aeas aou , a aeeaas aou , aeas aou , aeas aou , aeas aou , aeas aou , ase aasou ao, aeas more comareo a corresonneven a reerence same or u or wooes noavemesease.e suec w conroe.., same o a suec orreaeeocan caneene a o exs anncreaseeve or amoun o orreasease, ano s a suec susece oavn aorreaenecon,ncreaseeve or amourn omeorrseeaase.urn soormeer, emororemaen as,e,e sourreeca waron ex,orrse ana ^ aorornecaa, vaoraresaana a,neorsrorena,oursreanaae,sseorr,eoarr seae smnanca,,oorrreaur,orreaanu, orreaonesareocan caneene as a suec surea mamoo, anor anecon,orreasease, anormesease.n so sece oavn aorreae anncreaseeve oorreaeeocan ca me emomens,e suec wo exs mesease.n some emomens,e sueneene as a suec susece oavn orreaurorer,orrea ae, a c wo exs anncreaseeve or amoun o suec susece oavn aorreansororreaarneocan caneene as a n some emomens,eevease, aorreanecon, anormesease.^ seceseocanaso reerreoee or amoun o anorece aansorreae samesncrease aeas aour,en as an “an-eocan ano”n aooca , aeas aou , aeas aou a, aeaesas a aouou, aeas aou , aeas aou , aeas aou , aeas aou , aeas aou, a,ea ase aasou a, aeas aou aou or more comareo a corresonneven a reerence s ou , aeas suec wooes noavemesease or aorreasease amee.., same o a a suec w anncreaseeve or amoun o ornecon.n some emomens, asncreaseeve or amoun oorre anorece aansorreaeeocan eocans aorreaurorera,eeocan.n some emomens,eorreae orrea anerson,orrea orrea ae,orreaarn,orreaaonca, vaasana,orr sse,orrea snca,orreaur,orreaanu,orrea onesa eausanae,orrea seman,orrea mamoo, anor aorreae reocan.ccorn,n ceran emomens, a suec wo exs anncrease suvsee ocre am ooun o anorece aansorreaeeocan caneene as a suec navn aorreasease,orreaenecon, anormesease.^ oanerom somee sa emmeo sumeecn ws,eree rneereen receer seanmcee same..e, r weaesre oncaeneoorocra same cane orreasease,orreaenecon, anormesease.e., oe onse o a aorreaurorer,orrea ae,orreaar roroorreaenecone.., orreasse,orrea snca,o n,orreaaonca,orrea anerson,usanae,orrea s rreaur,orreaanu,orrea vaasana,orrea emomens,e reeeremncaen sa,morree caan mea omoaon,e anroomr a ao crorneroa sounesecar onr aecoonu.ano on oer ^ c eo.n.,roea su ceocns woo noave aorreasease,orreaenecon, anormesease, oo,asmna s,or smo ae s v eu ame , socs nom.^ veans,u a,o ceorecraa sa smnae coum,r osres u arness.uen, c ceer,a orn eomoumene.., ooca same comrses serum,asma, snovau, cerera s, a comnaon snau, urne, or an orreaurn ce oer rreoaern. ^ , emorromens,eeve or amoun oorreaeeocane.., a orre ea ae,orreaarn,orreaaonca,orrea anerson,usanaae,ssoerre,ao srreemaa snn,cao,rroerrae maaumro,o,o arnreoar aanu,orrea vaasana,orrea a snovau o a suec susece oavn ao orreaonesareocann meseasesncrease a rreasease,orreaenecon, anor aou , aeas aou , aeeaas aou, aeas aou , aeas aou , aeas aou , aeas aou , aeass a aou , aeas aou , aeas aou , aeaseas aou or more comareo a coou , aeas aou , aeas aou , a o a suec wooes rresonneven a reerence samee.., same n some em nooamveen as,o arnrenacreasseeasne,eorreeveae o ar anmeocunon o, aneo arn-meesoease.^ ano orramenereo oeresenscosures oserveone s can serum.ccorn,n ceran emomens,eeve o an novau anor snovau anor serum o a suec susece -eocan anoroenn a anormeseasesncr avn aorreasease,orreaenecon,eas aou , aeas aoease aeas aou, aeas aou , aeas aou , aeas aou , aeas aouu,, aeas aou , aeas aou , aeas aou , a aeas aou or more comar aeas aou , aeas aou , aeas aou , e.., sa eo a corresonneve or amounn a reerence same seasem. ^e o a suec wooes noave aorreasease,orreaenecon, anorme ano ornra sommeen emeroeom oense, arnesenncreassceonsureeve or amoun oe an-eocan an urne.ccorn,n cera es oserveone snovau, serum,n a snovau, serum anor unr enme oo am suenesc, sueseevcee o aanvn-e aoorreacan asneaseo,orrroeeane ^ nec, aon,ea asn aoroume,s aeaeseass anocruease, a aeaesas a aouou,, a aeas aou , aeas aou , aeas aou , aeas aou , aeas ao eas aou , aeas aou aou , aeas aou or more comareou , aeas aou , aeas reerence samee.., same o a suec wooes no a coarvrees aonornreaeves oears aem,ouonrren anecon, anormeseas aesowerann soemeev eemomeen.s ^,eeve or amoun o an-eocan anone serum ceran emomens, ore ameovuen o o a ann--eeooccaann a annoo onservee sernumes snoowvau.n corresonnevene snovau aeas aou, aeas erane , aeas aou , aeas aou , aeas aou , ae aou , aeas aou , aeas aou , aeas aou , aeas aou as aou , aeas aou , aeas aou , aeas aou , aeas a , aeas aou , aeas aou or more ou , aeas aou , aeas aouseran. n s ^omee emomens,eeve or amoun o an-eocan anone serum n ceran emomeevnes, ore ameovuen o or am anou-ne o ano-cean aonocan a onserovene snovau. ane corresonneve or amounne sno ne serumser , aeas aou , aeas aou , aeavau aeas aou, aeas aou , aeas aou , aeas aou , s aou , aeas aou , aeas aou , aeas aou , aeas ao aeas aou , aeas aou , aeas aou eocann soem.e., e amoorremeansu,reoeu rvee or am orou mnor oe. ^orreaeeocane..,orreae orrea anerson,orreasse,orrr,eoarr senaca a,eorr,eoarruera,aorrnre,orreaaonca, vaasana,orreausanae,orrea se aanu,orrea onesareocanne man,orrea mamoo, anor aorrea orreaenecon, anorm senovseaaseus a oe aa ssu aeocu sus.ecem o, aavenas a aoourreasease,eas aou m, aeas aou m, aeas aou m, aeas aou mm, aeas aou m, aeas aou m, aeas aou m, aeas aou m, a, ^ ameas, a aoeuas m, aeas aou m, aeas aou m, aeas aou saes onm seo amoeu se eamseonemm cenons o,r m m .eeor .,oe. as ^ essc,os,eeren cane useoanoseeeren canasscoverea.uro an, see sura.s sownnexames, eocanramen rer sesare amouns o anenc anmmunoenc emomens, surnsrowamos ereneraon.ccorn,n some rouee measurneeve o.urorereocaneerrec ornrec ano ve o an-eocan,anosc meosscoseeren cane useonecosne,oor e exaarm aen waen s aaoeum weees,ea wsennec aooun. wee aes, wona anoouse ea wree ssaes samrcuomars o avamneaesoeuasse ase. ea.r, arrreasm oern ne cuarno morae anorrevene more serous meosoreecn ear saem reoss.urren,ere are no reae anor anno soemse eremceo ameannss,ne asea orreos anen eoe enccro oena.se ^ caneves oorreaeeocan orreasease,orreaenecon, a , a suec susece oavn anammaor meaorsn aoocan saomremee..,se sasneovaasncurea,s seeruemve, o or u ornnee or. morero- emomens,eeve oro-nammaor meaorssncrea n ceran aou , aeas aou , aeas aou , aeas aouse aeas aou, aeas aou , aeas aou , aeas aou , aeas aou ,, aeas aou , aeas aou , aeas aou , aeas aou or more coma aeas aou , aeasn a reerence samee.., same o a s reo a corresonnevenecon, anor uec wooes noave aorreasease,orreae -,-,on--mm ,ne - esxeaamse.^ , ores co omnnaamomnasorer meoe.ano srosmnec eumeom-eαn,-α,-,-,nammaor meaorsne snovausreaerane c s,eeve oro-n a suec susece oavn aorreas orresonnevene serum n some emomen ease,orreaenecon, anormesease. ^ an-eocan an s,eeve or amoun oorreaeeocan,eeve ommunosocemsr,o a, anesoerrneeoven o, aron raamommamourno masesaa,or asns e mnezasmureen aen ^ mumcuneorsoonrenmm ausnsaouson m,e ao ra, ao romcmeunmomuunsoeone,cr aonmmunorecaon assa, an meo, a comemenxaon assa, , oress, assuemmunosann anaro annemmunooe aroen c,uraceasmonesonance, asu cromaora, a cnues,- ,mmuno-, coormerc assa, n some emomnen ms,asse seevcero omerorrecnues. ^ usn an an-eocan ano ornn eaeeocans measure an assa emomens,eorreaeeo aemmunroenscoseeren.n some arn,orreaaonca,orrea anecrasnons, aoorrrreeaasusreo,reorrr,eoar srenaca a,eorr,eaorurea orreaanu,orrea vaasana,orreausanae,orrea s r, mamoo, anor a eman,orrea n so orreaonesareocan.^ one or morenomwen emaonosmecn mse,oesaorno asso orreaerseesaesne,osrcreosuaree cnaene comne w sease, suc asoa n woe ce soncae as measu con, anorme s re mmunoo anor , or meca conn soom. ^ nes emao camens, one or moreanoscess cane useo rue ou oer serous an n cause smar smoms o aorreasease,orreaenecon, anorosnme sonsease,s e,. o.r, oouer.onrm as s oua aronr ws,e sruec aes s rueuemcaoa arrs, oseoarrs, conons,e suec canereaeore oer s s oer serous mecareamenormesease.n oer e erous meca conons on woue meca conons momens,e suec canereaeore oer serous n aon weorreasease,orreaenecon, anormesease.^ orreaee. s.,om ae eomrreoameunrs,o mreer,osorrescaos aeeer,enor craenae uasren,oorsnus acve orrea anerson,orreasse,orrea snca,o reaaonca, vaasana,orreausanae,o rreaur,orreaanu,orrea onesarsease orneconnecornreroam sreevmoauns e,xoosrurree.ao mrreamaoeo, aonocran araomrrea are reease onurn acverow oeacera, aneecon oes ens eneae currenromrevous exosure.^ e unue eoes can ^ anorronno ssonme a emororemaeensn,eceo mn,eoorreuraersenacseu aensoranomsen,s meaosneo orrn a, s sman, ereon a suecrom wce same was oane.n some emomens,e meomncues oannwo or more samesrome same suec, were one or m o oane awo or moreerenmeons.n some emomen ore samessare more mnues,as, wees, mons, orears aa s, anwoons are- or amoun anores oeocans orr rrom eac oer.n some emomens,e aanoss,ronoss, anor us amenereoeecene samesoeermne sease ororreaenecon,oerreoa monseoarse,o arnreoarenmeecosne,aseorrreoaresssoenas aen, anor roersmeo areamen onse unersoone or meermer casa “. raacncoes.s,” “ meraonsno ossu”, an “monorn” are commonace an we- “anoss”enera reersoeroce rer exanaon an woumaoneerm sease or cononn a s ss or ac o reconsn,ecn on or concun on a anoscroceuressucu aesc, oonr exeamases, oro smmnoowmsn ane srnesse annceo,r arsoemnc ree asunso or vuarous o one or moreomarers caracersc oeanosesease or cono an “ronosn” or “ronoss”enera reero an ancaon one n.eerms conon anerosece..,eroa,uraon, a roresson o asease or ronoss oeseases or cononsaueren nor exen o recover.oo sasacorara or comee recove maenera encomass ancaon o a acceaemeero.ooronrromeseases or conons,reera wn an nourer worsen oss o suc ma more common encomass ancaon o ronoss oesenas or aravan o suc,reera wn avenmeero.oor a susanar recoveres an or coorn unsaonssa acsoaru sowere renc movaer,e onrerao su enscaonmaass n aon rceaon o evenurer worsenn o cover or meseasne, sonmeec emon wo sumc aen.so,rreea meuourerncues san aorreasease anorerm “san”s usen acco rorer oransm, oro, or a smomereo.e es, an reers rance ws commonace usene meca anor veernar emomens,eoeveen, amonun w, aan soare ore oaseo orre aaseeaeseroorescsanonn a scuaeesc asonne. onr w somene ^ c oorns.eurreo wrer onnee ocr monor aes o suerecsesasne.nn socmaoer esmeo sameen oorreasease,mesease n some emomens,e meos seccoes,ecen su.ecs asmomac. emomens,e meooes noeec oerorrea sece urorer.n some acera, anor oer mcrooransms s, oer srocees, anor oer orreae seces aans o .n some emomens,e meos seccoeecn e amnoor omeenrs,e meos serec srcocoeees,ecancerao,rr aenao ara onser o mecrro sorroacnsemess.,nac seormae, urorer,n m sooc rmro reeor eaman aosm ems. ,enosr,re a maeaorn o,oanosnorreaenecone.., aorrea sse,orrea snca,or rreaaonca,orrea anerson,orrea orre reaur,orreaanu,orrea vaasana,orreausanae, rovea, see mmeano,nocrruena m aa cmonoaoc,n an ao sarm aeo orreaaneonreosmarennecvonuan w a su ane aces seccor one or moreorreae seceseocane.., an ano orr n eresenscosure, wc aens are oera neo aeecaeamenereo o mxure wasne reacon mxureree o unoun aen moen a reacon oreresence oouneocan-secc ae c anazne reacon mxure eocan, wereneresencesn noeermneeresence oorreaenvua worreaeneconerecave o aorreaenecon an anosne o a reerence samesee sence o oneeocan a aevereaeranaeas oneooc ce.n some emomens,e meourerncues coecn a eec a samerome suecroroa.n some emomens,necon cane eraee wucn aou wee, wn aou wees, wn aou wees aerenanecon. orreaseassceo,seca orreeornes aen anreec asoon, m aenoors omreeasnea,s conron, ameoran, or reucn a more smoms assocae w mese e anor a smomereoe.., one or suecene asavnm ase, e.., arrsn a suecn neeereoe.., a emomens,er esease usneanosc meosscoseeren.n some sue eamen oorreasease anmesease comrses amnsernoe anoc an or anra-moeneareone.s., aonrr aenaenenoncaranm.een., aner aeno-esocrrreeaenereaeorecaan ^ erasewmeenreeerreeon, a,n aoor an cuece coaaee en ocoronucne ane a ann a-no-rreorareeaeocan ano or orramenereo.n some emomenseorreaseas eeocan ano seases aorreaurorer,orre e,orreaenecon, anorme anerson,orreasse,orrea snaca a,oerre,aorurrea,oarrrena,aonrure,aoarroenaca v,aaosrraenaa orreausanae,orrea seman,orrea mamoo, anor aorr , ornecon.n some emomens,eorreaeeo eaonesarsease urorer,orrea ae,orreaarn, cansmeseases aorrea sse,orrea snca, orreaaonca,orrea anerson,orrea orrea seman,orreorare maamuroo,, aonrreora aanourre,aororenesaa vraaesanoa,ocrarne.ausanae, ereo, senc socmae emonsmeons,ee aonrreoae oreramoencane.reon seo.m.,e an emeon-mnenns, aranm aen eocan ano orramenereonsoorreaeeocan an reucesn- acv oorre smomereoma e n so oee r e ame secoo onmaerncasn c,.^ one moneoerencuesrean a suecornecon or ancun,u nomeo,orreaa o w one or more oer seces oorrea snca,orreau onca,orrea anerson,orreasse,orrea se r,orreaanu,orrea vaasana,orreausanae,orrea emomamne,nso,rresas mna amooo,noorrereaanarne, suorreeca aore., ourroorrreeraoornesar.n somesmomereo or a senecon or a^conar cononereo.exemes sow.nunroerxames, canasscovereaorreaeeocan as mononucear ereocan cannuce cese..,umanereraoo s cesoroucero-nammaor meaors uon smuaon.ccorn,n aommen esmeroemoe an ssu, aenc a,n caanonns ane. n.,e aunra anze-ee acovca on an.uororscoseeren, wen ere, reucee reease o sucro-nammaor mea ereocan, an ro-nammaor meaors, meossco ors.n, reucne reease o meseasee.., one or more smoms assseocaeere wn canrmeae, csoenasreo,, e. am.,e arorraes, o.r ^ reuce ^ oavnnm seomese eamseos rmeeunces,e aeveeas o aroou-na,m amaeaosr a moeuaorsn a suec suseceeas aou , aeas aou , aeas aou , aeas ao , aeas aou , aeas aou , aeas aou or more comareo a u , aeas aou , a amesease suec no reerencee.., corresonneven ano, reae w an anaonsscoseerene..,e an-eocan amnsra eo.., corresonnevene suecmmeaeroroe anaons -,-,onn.- ^m,n exam,es on,amm-aor, me-ao,rs ornc coumenao-nαs,-erαe,o.-n, som-e, e cmorreosomnenns,eveeevne oe serruom-nna am smuaeocr s museecaeors one snovausreaerane n some emomens,eraeuc meoasvnscomsesease.^ amnsern mue aenso a suece.., a eeren can comrse acve aenncunu nomeo ae n-eocan ano an a seconar anaesc, anor ocan-seccroase, an an-necve, an amns an an-rec.n suc emomens,e mue anaonss cane eren caenree c uosnecurnren conu onrc seonue wna on.en or so mmoer emomens,eraeuc meosscose sease.n ceran emomen e aona aensorereamen ome mn e s,e one or more aona aens comrse an anoc.on- ereo.xamer aes oo anna aoencss, cnoc-ueeraoxes,c ancn ceo,- amoxcn, ceraxone, or comnaons eseweree reamens areescrenreaerea nre son.^ nrave me emomens, an-eocan anos amnsereoe suecnramunsocuusar,, o sruacu,aneaoruesne,ranra,vrneraeca,nra-cererovenrcuar,umonar, n some emomens,esurae,r orreanravenrcuar. ^ anor comnaonera, e w a seconar acve aen, co-era, some emomens,e an su-cor arse aane oeosoeesccarn aennore,a seercoenaar es aecwvereeren.nreamen, anor co-eras amnsere or oerw e aen, co-nammaonne suecn neeereo.^ se ae orevereo a se o ^ usraveuurroesres em ono anmen arse n aroenuesnraeeonmeoe socwone oxaemnveesn won.c arevenor oownxoawmaevsnescrescer seomee a emoomens oeresenscosure,nenera,e emomens oeresenscosure areneascr emeonm coennnsec oon wereseenooswconsur eex. e ane corresonnex anures,eres noneno ames scosureosescron.ne con m emomens oeresen an euvaensncue wne srr aanr, scoeen oen emsoo cmoveenrs a o aeernraesvees, mocaons, oown exames areuor so asorove nscosure.e scosure anescron ose o ornar sne ar w a comee eren.orsaveee on moaweooe ernosrumre aecc mueracos w an u resseeeroesscose an cameemeraure, ec.,u some errors anevaons soue acccounoe numor.ersne.es.s, anmocuans, oerwse,ars arearsre wsseure a,reemeenraeu aressn ° ° an, an amr e anaremeraure an eosssureeres. a or near amoserc. xaammemunaon srae an resonseoorreaurorer muroees. urorerweooewceaenanaaeeenases weerenmmeunrazeme envsermur woeees wes.oses o. wereeseor ano ers aansnurc--a--u o anmas nurc--a--u-amma--rn ., orcc-c-aa--rn, . .nma was useo coec senoces anes cec-nurc . aans eac conesor secc enemen oram cen aove. er sceree cnonnes secc ceor c mouneros, ae susees o wans uesrees aonor counerseecon. common reeaseeocan r couner seecon aanse nurc--a--u- ramensnurc--a--u--s .,ra ora-scae recomnan mmroucon.ase, oanc.er s,ecc,or,a arne ane wnesr oe seneecrees.or ^ urcaonu arne an mass o an seec c mans o wne rreee aansaezeeoc-an.vea.urorer. ms, , , an , resecve .. s unes- corresono eec reeaseeocanresenn c sn recomnan mo mea ornaceocanrom cesunuarce suernaan.so.owen res cuusurne ecxansonsen m are caae oeecn reeaseeocan. aea aour mmuno- ocaene ucsera a cmoecnsa o ome,seas,e caus,n anorrea as soeceseocan. monocona anoesmmune-. caure aneecon eocanureromemeseases-c wauassn an o ereacnsvmes sraorereaoureecramens o ae, ano orer,orrea reoemasenaeonsrr o oe raeccaoa nmrn nnaen se m. ruomno. oco enxae arnoes are caae oeecnramens o nmas were neeenocuae wmen.aunece mce. were coece. comnaon o , , , anrorer m aonnocoonnau annao seerusm we sraem useso eer caure anensn serum oreecemmoze e ese resusncaea a coca o aour ano anens .. eocannmesease- ess caae oeecn reease ssaoeeceocannneucmean a unrmnae.s. monocornoace aunosoe meesm orr aanne-s wumeraen coaec wonr a comnaon o, , , an umanmeseaseaens or unnece, conroon.voouaes u wrenree sanmcueas coecerom memranes aneece usnon-aee ano e w coae eroxase cemumne es usn sreavn:orseras eocannuman urnscee.nce ..saa aeas suessasosseoeec xame ae wereeueennecraese reane scooreom mes oonxuacmeoee. seecuoemncesn oanaoee.e seuences o ^ ^ ^ ^ ^ ^ ^ ^ ^ *** ^ comosonsa,r anous mso oecanvoennso ann w varea aonasre onoeosescre meos,armaceuca rome scoe an sr oenvenon.o e sene ar wouearn w secc emome uenvenonaseenescren connecon envenon as camens s,o wu noe unee ursnouoames cao sauce o seucrecr e mmoocmaenonss ana varous mocaons oeescre moesor carrn .nee, ose sene ar areneneoe ouenvenona are ovousoneneo cover an varaons, uses, or a waanones s ocoee onveennovnenooonw.n,sn aencaons rnces oenvenon anncun sucearuresro era,e nown cusomarracce w meresenscosure come wn essenaea ne aro wcenvenonerans an mae aeoe unersoouurres reeerer re ae ncrn eue oeosr,e s eoeeaouo wrrens,. n anum eemreo asmeecnss o oeescoresseennvnenvenono.ne cearneeoscosuren an oerecen asecss acaeo anre nceo an comnaon o an numer ore cen numere asec an scosuren an comnaon orececne anse acssecsa, a csa rnecoe mnazee. aeoroowrane aneceen asecs arerove numere .e n an:o orramenere o caae o secca nn aorreae a.o orreaecan. ure aonrero,o orrreraam aene,eroerore oa asarecn,, worerreeanaeonocrare,aoerreeocans orreasse,orrea snca,orreaur, a anerson,usanae,or orreaanu,orrea vaasana,orrea . ere ana soem oranra,moernreae mreoam oo aon, o orn ae oor arseeacson-es,a wreerocan. ramenereos caae onna acan comone ene ano or oona acc-cc-anurc,an aa- n oeorreaeeocan, c aamma-rnnaen aorr rnnaen aorreaeeocan, nuurc. eaeeocan, or aorreae muroee comrsn ^ r.amenereeo an comors oesr ornaem ore mnoereo o an one o asecs-, werene ano ors- erc reoees eacneenenavn a seuencea . een aneonca orora onmee onr more o :-. a cme ereo o an one o asecso, werene anos . rc ane aon, auman ano, or aumanze ano. ramenereo comors oesr araam,e anae',re ao oa' an, one o asecso, werene ano or ere av, a sne canvscv, or comnaons r.o. amenereeo^ans soeec oerrraommenereorueo c oo an one o asecso, werene ano or varanereo, an an nssn o an , an , an , an , a r.amenereeo anso c oormranameonneerreeoo. o^ an one o asecso, werene ano or o.rrameneer aenosone a m ooro nor aan a comnee ann, aneeroereo oo or ar rnmn one an ommeu ansoceocnsu-a,e w.erene ano . e ano orramenereo o anam oneen oereo. ano orramene asecs-, werene monocona . onuceoreoe esn sceoecnerom-, , , or . . e ano orramenereo o an one o asecs- a s.euenceaeson-uceoerceen o asenecca,o w anereneonuceoe comrses or consss o . vecor comrsn:eonuceo oen oe o an s:-. . ce orouaonereo comrsn: one o asecs-. one o asecs- eon ae ano orramenereo o an or uceoe o an one o asecs-ce vecor o asec on. an co e o asecsam -rmancaeuoncea o ooarm- nuc uca. eoon ceo om arnsn on:ea o ase aencso- orrcameen veceorre oo o an e ce orouaonereo o asec, ore an com asec armaceuca acceae carrer. naon oa- an a ^ ae.n, wereneea crom-aceeruaecuaco armenuaso en o asec,urer comrsn a co-eraeuc . comrsn ecveoreamesease or a smomereo. eonuc :ae ano orramenereo o an one o asecs- ereo o aseoece o ane onee oa arsmeaccesuc-aorcmuea voenco or o an asec e ce orouaon com one o asecs- or an a.naon o orr meao-e o.eecn anoruann aorreaeeocan, anoranosn conacenaene aencono, an ororrammeenseeraesoe on a suecn neeereo,e meo comrsn: rome suecn nee an one o asecs- w aooca same eoca ereo aneecn anoruanne amoun oorreae u. n rorer,en or mreee s aoam ae oe. , asoercrea,a wrner,enoreorreaeeocans aorrea sse,orrea snca,orreaur,orreaanruea,aorornecaa, vaoarrseana anerson,orrea orrea seman,orrea mamo a,orreausanae, . e meo o an one oo, or aorreaonesareocan. as areaer amoun oorreaee asoecscan- as, co wmeraerenoe a reoeorencca same oe suec . e meo o an one o asecs-, w e or a conro same.neooca same oe sue ereneeve oorreaeeocan a aou , aeas aou , aeacss aoreuaera,n a aeaesas a aouou,, a aeeaass a aoouu ,, a aeeaasseaosu aou, aea,s a aeoasu aou, aeas or a mooure com,a areeaos a a cooru , aeas aou , a or conr resonnevene reerence u.o sam annsee me. reormoe on a vnro one o asecs-, werene conacn,eecn anor sn.ovau,e se mrueo o an o.ne o asecs-, wereneooca same comrses on.e or moreeer maem euo, or c o ur ae an nne. s. one o asecs-,urer comrsnreane suec w ^ an.o orrea mmeeno oere aose oc an, w oneere on aseec onse o-r moreeeraoeuncuc aeeonse co om arnse onae a on asaercmsaceu-cacormeu vaeconor o o a ans oecne o asceces ce- oreo auaeoraneuerceo a oen as eeeccveoreae .meseasee or m ae smo oom anere oo or an comnaon oa-e. comrse an ano o asecs-, werene one or moreeraeuc aens eocan-seccrroramenereo o an one o asecs-, an anoc, a ce.raxone, ore a mne coom ona asa oes nce, or ere, a o wn .e croemnnae aonneoreco c.omrsesoxccne, amoxcn, a.nos e meo o an one o asecs-, werenrean occurs aereecn anor ao.n. u weese a meer sous oec aenn oneec o asecs-, werene conacnserorme wn . e meo o on worreae oransm. orrea ae asec, wereneorreae oransmsorreaurorer, o ,orreaarn,orreaaonca,orrea anerson,orreasse, sreremaan s,ncoar,reoarr meaamuroo,, oorrreorareanauon,esoarrre.a vaasana,orreausanae,orrea ^ o.rreaenec meono or a o smreaomn aereoor,r aenaeoremeosecaasnesease or smomereo, an neeereo,e meo comrsn or a smomereon a suec one o asec : amnserna an ano orramenereo o an ce ces o-rouaoenoerneuoc oeo asee oc an one oe asaremcasceu-cacormuea veocnor o asec o asecs- ore an comnaon oa-oe suecn n o an one . meo o reucn,nn, or ameoran one oere mereo. anororreaeseasen a suecn nee ore smoms ome amoun oa an an ereo comrsn amnsernoe suec an o an one o asecso- orcrame venecorer oeo as oec an once oe as ceec osr-ouaoneeorenuceoe earmaceucaormuaon o an one o asecs- o o asec . ore an comnaon oa- on.e or morereo m-neaomm oa aonr m onee oao arssencse su-e,c w coemrenar aemon as reerenrenc ree ourc aeseeve o . e meo o asec, werene one or morero-n conro. comrse-α,-α,-,-,-,-,-, or ammaor meaors . e meo o an one o asecs-, wer ceomnaonsereo.nammaor meaorss reuc neeve o one or morero-eas aou , aea e aeas aou, aeas aou , aeas aou , aeas aou s aou , aeas aou , aeas aou , aeas aou , a . e, m aeeoas aou or more comareoe reerence. ao o an one o asecs-, werene suecs amnsere an an.naer oc or aea e meuec oo ae on. can a-sseeccc, wroeraesne aonaeraeuc aen comrses an am.oxcn, cee mreaxoone, o or as coemcna,onae s w. ereeore,ne w aneroc comrsesoxccne, roase comrses an amase or as eneeocan-secc . e meo o an one o aoszecmse, or-c, woerea an. avnme arrs, neuroorreoss or oermeseasen-reeae su cecncaas m oarnse ssuaseocnse. o ^

Claims

as cames: .eocann. ano orramenereo caae o secca nn aorreae .orreaureo ano orramenereo o cam, wereneorreaeeocans a orreasser,ero,rreorare snac aa,eor,reoarreura,aronrre,aorarneua,aoornrecaa, voararesaan aan,eorrsron,usanae,orrea seman,orrea mamoo, or aorreaonesareocan.ea s. caaee ano orramenereo o cam, werene ano orramenereo cc-a onnurnc,a a ancan comonen oeorreaeeocan, oona acc- naen aorreaeeo acaan-, ornrn aaeorrne aaeo mrrueroaeeee coomrcasnn,cn auaumrma-c.rn co.mrses onee o arn mooreo orreameens eacereon oee cnaemn, waerene ano orramenereo encao one or more o :-. vn a seuenceas- ercen an.o, auema ann anoo or, orra amuemnanzeereo an oo ca.m, werene anos a cmerc co.mrses aae a,n aao', a orraa'm,e anv,e are son oe c caamn,v wsecrevn, ore c aonmona oornsraemreeon.ereo s. seeceroem^aneorou orramenereo o cam, werene ano orramenereo an an comnaonereo co.^nssn o: an , an , an , an , a varanereo, ^s.neo ane a anen,oer oerraormmenn aneremom oun cocaomnu,a we.erene ano orramenereo s. a monoconea a annoo o orrrraammeenneerreeoo o. cam, werene ano orramenereo se.ecerome an-,o o,rram,e onrere.o o cam, werene monocona anos . onuceoe encone ano orramenereo o an one o cam. se.uenceaeso-nuceeorceen o cenamcao, w aner oenne oeonuceos:e- com.rses or consss o a . veecoorn cuocmeorsne o: an one o cams-. . a. cee o arnooua oonereo comrsn: .eonuceorrae ome ann oenreeo o an one o cams- c.e vecor o cam o cams- . an comnaon oa- orc. . a.aerm anaceuoca ororramumaenon ceomrsn: ..eo reo o an one o cams- c nuceoe o an one o cams- .ee v ceeco or o cam or e. a rouaonereo o cam or an caormmacenuacoan o acac-ea ane carrer. ^w.erene coe-earrameauceuc acaenorsm euaeconve oo carema,muer’sers ceoamse orrs an s am co-omeraeereuoc. aen, . a. c .eo e amnr onosn uce o: orramenereo o an one o cams- c. e o an one o cams- .ee vecor o cam or e.e cear omraco aeuu oncaonereo o cam . an comna ooarm-uea.on o an one o cams- or a.orreaen meeo oeecn anoruann aorreaeeocan, anoranosn conacconn, ane aonrome’ osrrsaeasen a suecn neeereo,e meo comrsn: samerome suecn neeereo anmeneecerneo a on aonr ounae o cams- w aooca eocanne same. nne amoun oorreae o.rrea aee m,eoorre oa caamrn,, woerrreenaeaoornreca,aeoerreao ancaenrsso an,orroerraeurorer, orrea snca,orreaur,orreaanu,orrea vaasana,orreausanaae,sse, seman,orrea mamoo, or aorr orrea . e meo o cam, weereanonesareocan. amoun oorreaeeocan as comareeo ao reoerceance sa omr coen oro seam suee.cas areaer sam.e oee s meo o cam, wereneeve oorreaeeocanneoocaeas aouu, aeceass areoaueran, a aeeaass a aoou, aeas aou , aeas aou , aeas aou , aeas aou , aeas aouu ,, a aeeaass a aoouu , a, aeaesas a aouou, a aeas aou or more comareo a corresonnevene reerence or conro same,. ^er.ormen ve mroe.o o cam, werene conacn aneecn anoruanns ser.um, or urnee. meo o cam, wereneooca same comrses snovau, e.raeuc aeen mse.o o cam,urer comrsnreane suec w one or more an.o orrae mmeo o cam, werene one or moreeraeuc aens comrsea an -ce venereo o an one o cams- eonuceoe o an one o cams armaceueacsae ooe rrc amor o cam ce ce orouaonereo o cam e me’ss sumaonom o aenreo one o or c aanms com-naeon a oeara-eeu.c aen eecveorea com.rse an ane meo o an o cams-, werene one or moreeraeuc aens or an comnaoon oere aon. one o cams-, an anoc, aeocan-seccroase, ce.raxone, ore a mne coom ona caonmer,eo w.erene anoc comrsesoxccne, amoxcn, a.nosn.e meo o an o cams-, werenrean occurs aereecn anor ao.u weese a meer sous oec aenn oneec oon c wams ao-rre, waee orrenansem c.onacnserorme wn ^o.rrea aee, meorore oa caarmn,,o wrreereneorreae oransmsorreaurorer, orrea snca,orreaur,orreaanuaa,oonrrcea,a voarrea anerson,orreasse, seman,orrea mamoo, ororreaonesar. asana,orreausanae,orrea o.rreaenec meono or a o smreaomne areoo,r arenaoereme’ossceaansease or smomereo, an neeereo,e me se or a smomereon a suec onuceo ame ons anerno onea co o am cna arnsn mo: orramenereo o an one o cams- e ereo o cam s-ce vecor o camce ce orouaon comnaon oa-oee suaremcacenu neceaoerrmeoua.on o an one o cams- ore an an.ororre maeeo oo recauncnse,asnen an su, oerc ameoran one or more smoms ome’s suec an amouna an ano orramenn neereeo oereo an co omner osn c aammsnsernoe onuceoe o an one o cams-ce vecor o ca - e ereo o cam earmaceucaor mce ce orouaon comnaon oa-. muaon o an one o cams- ore an or. morero-ne mamemoao or a mne onaeo ors cnames su-ec, w comerearne amo an rseeerrennc ree oruc ae csoneroe.ve o one com.rsee-α m,e-oα, o- ca,m-,,- w,eren-,e- one, o orr c momorenaroo-nnsamermeoa.or meaors n.amme meo o an one o cams-, wereneeve o one or morero-eas aoauor m,e aaeoarss as roeuuce, a aeaesas a aouou,, aeas aou , aeas aou , aeas aou , aeas aou or more comareo aeea rse aereonuce or,e a coenasro a.ou , a ^a.onaerea meueco ae on. an one o cams-, werene suecs amnsere an an.oc or aee meoo ocan c-saemcc, wroeraesen.e aonaeraeuc aen comrses an ce.raxone meo o cam,a werene anoc comrsesoxccne, amoxcn, an amasee, o orr a comsoznameo,n osrcereoo,a w aneren.eeocan-seccroase comrses av.nme aer mreso, ne ouro anor oreneo oss c ora omser-m,e wseeraesen-reea seu cecncaas m oarnse ssuaseocnse. o ^

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