A biomaterial containing encapsulated irisin for bone grafts

Abstract

The invention is a biomaterial for bone grafts. The biomaterial is characterised by the comprising irisin. The said irisin is encapsulated. The said irisin is incorporated into a biocompatible scaffold.

Description

[0001] A Biomaterial Containing Encapsulated irisin tor Bone Grafts

[0002] Field of the Invention

[0003] The present invention relates to the field of medicine, in particular to the field of dentistry, and more particularly to a biomaterial comprising encapsulated irisin particles. The invention also relates to the use of said biomaterial for the treatment of bone loss, and more particularly for the treatment of bone loss, such as in the jaw bone, long bones and skull bones.

[0004] State of the Art

[0005] In cases where bone grafting is necessary, the most preferred and most successful method is autogenous grafts. However, in some cases, donor site morbidity occurs during bone harvesting. In cases where large amounts of graft are required, the donor site is insufficient. To solve this problem, allograft, xenograft and alloplastic materials have been discovered. But these types of grafts also have some disadvantages.

[0006] For example, when allograft, xenograft and alloplastic are used in patients who require augmentation before dental implants, rapid resorptions are observed and the grafting process is insufficient. For this reason, the process needs to be repeated. In addition, after the grafting process, a long period of time of six months must be waited for the fusion with the natural bone tissue. Patients often give up on dental implants because they cannot afford to wait this period. In this case, patients prefer traditional removable and / or fixed prostheses instead of more comfortable implant-supported prostheses.This choice of the patient reduces the quality of life.

[0007] As in this example, waiting time and possible resorptions are also problems encountered in other surgeries. In addition, the quality of the new bone tissue obtained with the use of these grafts is not the quality of the patient's own bone tissue. For this reason, additional costs arise for both the patient and the physician. Brief Description of the Invention

[0008] The present invention discloses an encapsulated irisin particle. Irisin, a hormone known for its role in promoting bone growth and regeneration, is encapsulated in biocompatible materials to improve its stability and controlled release. The bone graft composite provides a localized and sustained release of irisin, which promotes osteogenesis and accelerates the regeneration of tissues such as the jawbone.

[0009] The invention is a biomaterial for bone grafts. The biomaterial is characterised in that it comprises irisin. The said irisin is encapsulated. The said irisin is incorporated into a biocompatible scaffold.

[0010] Detailed Description of the Invention

[0011] The ideal bone graft should be biocompatible, absorbable, have osteoconduction and osteoinduction properties, and be able to promote new bone formation to replace completely lost bone. For this purpose and to solve known problems in the art, the present invention provides a encapsulated irisin particle.

[0012] When used by mixing encapsulated irisin particulates with bone grafts, it increases the properties of bone grafts. Encapsulation of irisin provides protection, stability and controlled release at the application site. In this way, better healing of bone grafts by fusing with the natural bone tissue of the patients, is achieved, a higher quality bone tissue is obtained, and the ossification process is shortened.

[0013] Irisin and osteocalcin are two important molecules that show that muscle activity and bone metabolism are interconnected. Irisin is a hormone secreted by muscles during exercise, and osteocalcin is a hormone that plays an important role in bone formation. Irisin promotes bone formation by increasing the release of osteocalcin during muscle activity. At the same time, osteocalcin helps strengthen the effects of irisin by regulating brain functions and metabolism. Therefore, the interaction between irisin and osteocalcin demonstrates the link between muscle activity and bone metabolism.

[0014] The irisin hormone is encapsulated with the micro-particle encapsulation method, allowing the said hormone to be released slowly in the desired areas / sites. Irisin, a newly identified myokine produced by skeletal muscle after physical exercise, was initially identified as a molecule capable of promoting energy expenditure in white adipose tissue. However, later it was shown in various studies that irisin increases cortical bone mass.

[0015] In another embodiment of the present invention, the irisin is incorporated encapsulated in different structures such as scaffold. Biocompatible scaffold material can be selected from hydroxyapatite or synthetic polymers.

[0016] In another embodiment, irisin is prepared by encapsulating it in microspheres or nanoparticles, which are then incorporated into the scaffold material. The size, shape, and composition of the encapsulated irisin particles can be optimized to achieve the desired release kinetics and biocompatibility.

[0017] In another embodiment of the invention, irisin can be used by encapsulating it with other materials that can increase the hormone activity and effects. It can be impregnated into different graft materials.

[0018] In another embodiment of the present invention, the encapsulated irisin particles may further comprise additional bioactive substances, growth factors or osteogenic substances to enhance bone regeneration.

[0019] In another embodiment, methods with more effective delivery and release than encapsulation can also be used.

[0020] In another embodiment of the present invention, encapsulated irisin with different release rates can be adapted to intra-tissue or intravascular injection methods in order to benefit from the positive effects of irisin on other organs other than bone.

[0021] The encapsulated iris particles provided by the present invention can be used in dental implantology for alveolar crest augmentation, sinus elevation operations, for the treatment of periodontitis or perimplantitis, in craniomaxillofacial surgery, can also be used in the treatment of alveolar clefts, repair of defects following excision of pathological conditions involving short and long bones, spinal fusion, surgeries involving the bones of the hands and feet and wrists, including but not limited to.

[0022] In one embodiment, the encapsulated irisin particles of the present invention are a dental bone graft. These particles can be applied to the site of jaw bone loss via minimally invasive surgical techniques. Upon application, encapsulated irisin is gradually released from the scaffold, stimulating osteoblast activity, increasing bone matrix formation and promoting new bone growth. This accelerates the regeneration of jaw bone tissues and increases the overall success rate of dental implant procedures.

Claims

CLAIMS1. A biomaterial for bone grafts, characterized by comprising; irisin.

2. The biomaterial according to claim 1 , characterized by comprising; encapsulates irisin.

3. The biomaterial according to claim 1 or 2, characterized in that, irisin is incorporated into a biocompatible scaffold.