A method and computer device for evaluating the protective effect of a protective composition to be applied to a user's keratinous material

Abstract

A method and computer-aided device for evaluating the protective effect of a protective composition applied to a user's keratinous material. A method and device are provided for evaluating the protective effect of a protective composition applied to a user's keratinous material. The method includes applying the protective composition to a first test area of ​​keratinous material; applying an inducing agent that causes redness and / or discomfort to the keratinous material over the applied protective composition; removing the protective composition and the inducing agent; imaging the first test area to obtain a first parameter value; measuring the first test area to test transepidermal water loss to obtain a second parameter value; and evaluating the protective effect from the parameter values. Figure for abstract: Fig. 1

Description

Title of the invention: A method and a computer device for evaluating the protective effect of a protective composition to be applied to a user's keratinous material. Technical field

[0001] The disclosure relates to the field of cosmetics. More specifically, the disclosure relates to a method and a computer device for evaluating the protective effect of a protective composition to be applied to a user's keratinous material. CONTEXT

[0002] Today, people are increasingly seeking outward beauty. Clothing, makeup, keratinous materials, and various types of hair care products help meet these beauty needs. Typically, people apply protective compositions to keratinous materials before applying certain makeup products, hair care products, and so on. In the prior art, there are no quick and effective methods for evaluating the protective effect of compositions applied to keratinous materials.

[0003] There is therefore a need for a method of evaluating the protective effect of a protective composition to be applied to a keratinous material of a user, more particularly in terms of redness and discomfort values ​​for the keratinous material, in a fast and more efficient manner. SUMMARY

[0004] The summary is provided to present a selection of concepts in a simplified form, which are further described below in the detailed description. This summary is not intended to identify key features or essential characteristics of the claimed subject matter, nor to be used to limit the scope of the claimed subject matter.

[0005] Various aspects and features of the disclosure are described in more detail below.

[0006] According to a first aspect of the disclosure, a method for evaluating the protective effect of a protective composition to be applied to a user's keratinous material is provided. The method includes applying the protective composition to a first test area of ​​the user's keratinous material; applying an inducing agent that will cause redness and / or discomfort to the user's keratinous material over the applied protective composition; removing the applied protective composition and the applied inducing agent from the first test area; and imaging the first test area with an imaging device to obtain a first parameter value.

[0007] the measurement of the first test area by a device to test the transepidermal water loss of keratinous material to obtain a second parameter value; and the evaluation of the protective effect on the basis of the first parameter value and the second parameter value.

[0008] In one embodiment of the first aspect of disclosure, the method also includes obtaining first self-perceived sensation information for the first test area from the user after the step of removing the applied protector composition and the applied inducing agent from the first test area; and evaluating the protective effect based on the first parameter value, the second parameter value and the first self-perceived sensation information.

[0009] In another embodiment of the first aspect of disclosure, the method also includes the direct application of the inducing agent to a second user test area; the removal of the applied inducing agent from the second test area; imaging the second test area by the imaging device to obtain a third parameter value; measuring the second test area by the device to test the transepidermal water loss of the keratinous material to obtain a fourth parameter value; and evaluating the protective effect by comparing the first parameter value and the third parameter value and by comparing the second parameter value and the fourth parameter value.

[0010] In yet another embodiment of the first aspect of disclosure, the method also includes obtaining a first self-perceived sensation information for the first test area after the step of removing the applied protector composition and the applied inducing agent from the first test area; obtaining a second self-perceived sensation information for the second test area from said user after the step of removing the applied inducing agent from the second test area; wherein the evaluation step also includes evaluating the protective effect based on the result of comparing the first parameter value and the third parameter value, the result of comparing the second parameter value and the fourth parameter value, and the result of comparing the first self-perceived sensation information and the second self-perceived sensation information.

[0011] According to a second aspect of the disclosure, a computer device is provided to evaluate the protective effect of a protective composition to be applied to a user's keratinous material, includes an imaging device comprising a set of computing circuits configured to obtain images of a first test area of ​​the user's keratinous material to obtain a plurality of first images; a measurement unit comprising a set of computing circuits configured to measure the first test area to obtain a second parameter value; and a processor comprising a set of computing circuits configured to process the plurality of first images for the first test area to obtain a first parameter value and evaluate the protective effect on the basis of the first parameter value and the second parameter value; wherein, prior to imaging the first test area, a protective composition is applied to the first test area; then an inducing agent is applied which will cause redness and / or discomfort to the user's keratinous material over the applied protective composition; finally, the applied protective composition and the applied inducing agent are removed from the first test area.

[0012] In another embodiment of the second aspect of disclosure, the processor includes a set of computing circuits configured to also receive first self-perceived sensation information for the first test area from the user after the applied protector composition and the applied inducing agent have been removed from the first test area; and evaluate the protective effect on the basis of the first parameter value, the second parameter value and the first self-perceived sensation information.

[0013] In yet another embodiment of the second aspect of disclosure, the imaging device includes a set of computing circuits configured to also obtain images of a second test area to obtain a plurality of second images; the measuring unit includes a set of computing circuits configured to measure the second test area to obtain a fourth parameter value; and the processor includes a set of computing circuits configured to process the plurality of second images for the second test area to obtain a third parameter value and evaluate the protective effect by comparing the first parameter value and the third parameter value and by comparing the second parameter value and the fourth parameter value; before obtaining images of the second test area, the inducing agent is applied directly to the second test area;then the applied inducing agent is removed from the second test area.

[0014] In yet another embodiment of the second aspect of disclosure, the processor includes a set of computing circuits configured to receive first self-perceived sensation information for the first test area from the user after the applied protective composition and the applied inducing agent have been removed from the first test area, and also to receive second self-perceived sensation information for the second test area from said user after the applied inducing agent has been removed from the second test area; and to evaluate the protective effect based on the results of a comparison between the first parameter value and the third parameter value. comparison between the second parameter value and the fourth parameter value; and comparison results between the first self-perceived sensation information and the second self-perceived sensation information.

[0015] In one example of the disclosure, the imaging step is performed by an imaging device and the measurement step is performed by a device to test the transepidermal water loss of keratinous material.

[0016] In an example of the disclosure, the first test area and the second test area can be either the back of the ear, the forearm, or any area of ​​the keratinous material. In an example of the disclosure, the first and third parameter values ​​are redness values ​​of the keratinous material; the second and fourth parameter values ​​are transepidermal water loss values ​​of the keratinous material; and the first and second self-perceived sensation information are information related to itching, burning, and tingling.In one example, the removal of the applied protective compound and the applied inducing agent from the first test area is performed approximately 5 to 15 minutes after the application of the inducing agent, which will cause redness and / or discomfort to the user's keratinous material overlying the applied protective compound. In another example, the removal of the applied inducing agent from the second test area is performed approximately 5 to 15 minutes after the direct application of the inducing agent to the second test area. In a preferred example, the protective compound is applied at a rate of approximately 0.01 g–0.1 g / cm² and the inducing agent is applied at a rate of approximately 0.1 g–1 g / cm².

[0017] According to a third aspect of the disclosure, a computer-readable medium is provided on which instructions are stored which, when executed, cause a computer device to carry out the process according to the first aspect of the disclosure.

[0018] According to a fourth aspect of the disclosure, a method for evaluating the protective effect of a plurality of different protective compositions to be applied to a user's keratinous material is provided, the method comprising the following steps: application of each of the plurality of different protective compositions to each of a first plurality of test areas behind the user's ear and to each of a second plurality of test areas on the user's forearm, respectively; application of inducing agents that will cause redness and / or discomfort to the user's keratinous material over each of the different protective compositions applied, respectively; and removal of the different applied protective compositions and the applied inducing agents from the first plurality of test areas and the second plurality of test areas respectively; imaging of the first plurality of test areas by an imaging device to obtain a first plurality of parameter values; measurement of the second plurality of test areas by a device to test the transepidermal water loss value of the keratinous material to obtain a second plurality of parameter values; and evaluation of the protective effect based on the first plurality of parameter values ​​and the second plurality of parameter values.

[0019] According to an embodiment in a fourth aspect of the disclosure, the method also includes the steps of obtaining a first plurality of self-perceived sensation information for the first plurality of test areas from the user after the step of removing the different applied protector compositions and applied inducing agents from the first plurality of test areas; and of evaluating the protective effect on the basis of the first plurality of parameter values, the second plurality of parameter values ​​and the first plurality of self-perceived sensation information.

[0020] According to another embodiment in a fourth aspect of the disclosure, the method also includes the steps of directly applying the inducing agents to a third test area on the back of the user's ear and to a fourth test area on the user's forearm; removing the applied inducing agents from the third test area and the fourth test area; imaging the third test area by the imaging device to obtain a third parameter value; measuring the fourth test area by the device to test the transepidermal water loss of the keratinous material to obtain a fourth parameter value; and evaluating the protective effect by comparing the first plurality of parameter values ​​and the third parameter values ​​and by comparing the second plurality of parameter values ​​and the fourth parameter value.

[0021] According to yet another embodiment in a fourth aspect of the disclosure, the method also includes the steps of obtaining a third self-perceived sensation information for the third test area after the step of removing the applied inducing agent from the third test area; in which the evaluation step also includes the evaluation of the protective effect by comparing the first plurality of parameter values ​​and the third parameter values; by comparing the second plurality of parameter values ​​and the fourth parameter value; and by comparing the first plurality of self-perceived sensation information and the third self-perceived sensation information.

[0022] In one embodiment of a fourth aspect of the disclosure, the first plurality of parameter values ​​and the third parameter value are redness values ​​of the keratinous material at the back of the ear; the second plurality of parameter values ​​and the fourth parameter value are transepidermal water loss values ​​of keratinous material on the forearm.

[0023] In an embodiment of a fourth aspect of the disclosure, the removal steps are carried out approximately 5 to 15 minutes after the application steps of the inducing agents over the different protector compositions applied to the first plurality of test areas and to the second plurality of test areas and direct application of the inducing agents to the third test area and to the fourth test area.

[0024] In one embodiment of a fourth aspect of disclosure, the first plurality of self-perceived sensation information and the third self-perceived sensation information are information related to itching, burning, and tingling.

[0025] In an embodiment of a fourth aspect of the disclosure, the different protector compositions are applied at a rate of about 0.01 g-0.1 g / cm2, and the inducing agents are applied at a rate of about 0.1 g-1 g / cm2.

[0026] According to the publication, an objective and subjective evaluation of the composition of protector to be applied to a keratinous material of the user can be carried out quickly and more efficiently, which makes it possible to obtain a more accurate and quantified evaluation result. Brief description of the drawings

[0027] The above and other aspects, features, and advantages of various embodiments of the disclosure will become more apparent, by way of example, from the following detailed description with reference to the accompanying drawings, in which similar reference numerals or letters are used to designate similar or equivalent elements. The drawings are illustrated to facilitate a better understanding of the embodiments of the disclosure and are not necessarily drawn to scale, in which:

[0028] [Fig-1] Figure [Fig.1] illustrates a flowchart of a process 100 for evaluating the effect of protection of a protective composition to be applied to a keratinous material of a user in accordance with a first embodiment of a first aspect of this disclosure;

[0029] [Fig.2] Fig.2 illustrates a flowchart of a process 200 for evaluating the effect of protection of a protective composition to be applied to a keratinous material of a user in accordance with a second embodiment of a first aspect of this disclosure;

[0030] [Fig.3] Fig.3 illustrates a flowchart of a process 300 for evaluating the effect protective composition to be applied to a keratinous material of a user in accordance with a third embodiment of a first aspect of this disclosure;

[0031] [Fig.4] Fig.4 illustrates a flowchart of a process 400 for evaluating the protective effect of a protector composition to be applied to a user's keratin material in accordance with a fourth embodiment of a first aspect of this disclosure;

[0032] [Fig.5] The [Fig.5] illustrates a schematic diagram of a computer device 500 for evaluating the protective effect of a protective composition to be applied to a keratinous material of a user in accordance with a second aspect of this disclosure. DETAILED DESCRIPTION

[0033] The embodiments in this document will be described in detail below with reference to the accompanying drawings, in which the embodiments are illustrated. These embodiments in this document can, however, be implemented in many different forms and should not be interpreted as being limited to the embodiments stated herein. The elements in the drawings are not necessarily to scale with respect to each other. Throughout the document, like numbers refer to like elements.

[0034] The terminology used in this document is used for the purpose of describing particular embodiments only and is not intended to be restrictive. As used in this document, the singular forms "a", "an", "the", and "the" are also intended to include the plural forms, unless the context clearly indicates otherwise. It shall also be understood that the terms "includes", "comprising", "contains", and / or "including", when used in this document, specify the presence of the particularities, integers, steps, operations, elements, and / or components indicated, but do not exclude the presence or addition of one or more other particularities, integers, steps, operations, elements, components, and / or groups thereof.

[0035] Unless otherwise defined, all terms (including technical and scientific terms) used in this document have the same meaning as generally accepted. It shall further be understood that a term used in this document shall be interpreted as having a meaning consistent with its meaning in the context of this specification and the relevant art and shall not be interpreted in an idealized or excessively formal sense unless expressly defined in this document.

[0036] The present technology is described below with reference to the schematic diagrams and / or flowchart-type illustrations of the processes, apparatus (systems) and / or computer program products according to these embodiments. It is understood that the blocks in the schematic diagrams and / or flowchart-type illustrations, as well as combinations of blocks in the schematic diagrams and / or flowchart-type illustrations, can be implemented by computer program instructions. These computer program instructions can be provided to a processor, a control device, or a control unit of a general-purpose computer, a specialized computer, and / or other programmable data processing device to produce a machine, such that the instructions, which execute via the processor of the computer and / or other programmable data processing device, create means to implement the functions / actions specified in the schematic diagrams and / or the flowchart block(s).

[0037] Therefore, this technology can be incorporated into hardware and / or software (including firmware, resident software, microcode, etc.). Furthermore, this technology can take the form of a computer program product on a computer-usable or computer-readable storage medium having computer-usable or computer-readable program code embedded in the medium for use by or in connection with an instruction-executing system. For the purposes of this document, a computer-usable or computer-readable medium can be any medium that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction-executing system, apparatus, or device.

[0038] The embodiments in this document will be described below with reference to the drawings.

[0039] The inventive concept consists of evaluating the protective effect of a protective composition to be applied to a keratinous material of a user, more particularly in terms of redness and discomfort values ​​for the keratinous material.

[0040] Fig. 1 illustrates a flowchart of a method 100 for evaluating the protective effect of a protector composition to be applied to a user's keratin material in accordance with a first embodiment of a first aspect of this disclosure.

[0041] Before the procedure, certain actions must be taken. The user is not permitted to use any cosmetic products (including routine skincare products) on the back of the ear 24 hours before the test and is not permitted to take a sauna or bath. Before the test, the user must be aware of the written informed consent and indicate the inclusion / exclusion criteria (primary eligibility) and medical history. During the test, the user must clean the test area on the back of the ear with water and dry it by patting it with a paper towel; wait 30 minutes in an environment with constant temperature and humidity.

[0042] Process 100 begins. In block 101, a protective composition is applied to a first test area of ​​the user's keratinous material. In the context of disclosure, the protective composition may be a protective product for the user's keratinous material. In one example, the test area may be the back of the ear, the forearm, or any other area of ​​the user's body. In one example, the protective composition is applied at a rate of approximately 0.01 g–0.1 g / cm². In block 102, an inducing agent that will cause redness and / or discomfort to the user's keratinous material is applied over the applied protective composition. The inducing agent may be one with a high pH ingredient that is likely to induce redness and discomfort in the keratinous material. In one example, the inducing agent is applied at a rate of approximately 0.1 g-1 g / cm2.In block 103, the applied protective composition and the applied inducing agent are removed from the first test area. Block 103 is performed within a predefined time period following block 102. In one example, the predefined time period could range from 5 to 30 minutes, preferably from 5 to 15 minutes. In block 104, the first test area is imaged by an imaging device to obtain a first parameter value. More specifically, to obtain a more accurate result, the first test area is imaged repeatedly by the imaging device to obtain a plurality of first images, and then the plurality of first images are processed to obtain the redness value for the keratinous material. In one example, such an imaging device could be a camera, a mobile phone with imaging capabilities, a notepad computer with imaging capabilities, and so on.In block 105, the first test area is measured to obtain a second parameter value. For example, block 105 could be performed using a device to test the transepidermal water loss of keratinous material, and the second parameter value could be the transepidermal water loss values ​​of keratinous material. The order in which blocks 104 and 105 are performed can be changed. In block 106, the protective effect is evaluated based on the first and second parameter values. Method 100 allows for a rapid and objective assessment of the protective effect, such as the redness and discomfort of the keratinous material's protective composition.

[0043] Figure 2 illustrates a flowchart of a method 200 for evaluating the protective effect of a protector composition to be applied to a user's keratin material in accordance with a second embodiment of a first aspect of this disclosure.

[0044] In order to better evaluate the protective effect of a protective composition to be applied to a user's keratinous material, the disclosure relates to a objective evaluation combined with a subjective evaluation process of the protective effect of a protective composition to be applied to a user's keratinous material.

[0045] As shown in [Fig. 2], the process 200 comprises blocks 201, 202, 203, 204, 205, 206, and 207. Blocks 201, 202, 203, 204, and 205 are the same as blocks 101, 102, 103, 104, and 105 shown in [Fig. 1]. Thus, blocks 201, 202, 203, 204, and 205 are not described in detail. As shown in [Fig. 2], the protective composition is applied to the first test area (see block 201), and then the inducing agent is applied to the applied protective composition (see block 202); by means of blocks 203 and 204, a first parameter value and a second parameter value are obtained, respectively. In one example, the first parameter value could be a redness value of the keratinous material for the first test area and the second parameter value could be transepidermal water loss values ​​of the keratinous material for the second test area.

[0046] In block 206, the first self-perceived sensation information for the first test area is obtained from the user after the removal block 203. Preferably, the first self-perceived sensation information for the first test area is obtained from the user within 5 to 30 minutes, and more preferably within 5 to 15 minutes, after the removal block 203. In one example, the first self-perceived sensation information is related to itching, burning, and tingling. The execution order of blocks 204, 205, and 206 can be changed. In block 207, the protective effect is evaluated based on the first parameter value, the second parameter value, and the first self-perceived sensation information.Compared to traditional self-assessment for evaluating the effectiveness of protection on keratinous material after chemical treatment, disclosure can allow for an objective evaluation combined with a subjective evaluation process.

[0047] To better understand the technical solutions of processes 100 and 200, an embodiment will be given. In such an embodiment, we can take an area behind the ear as the first test area and use a specific type of scalp protectant as the protective composition during the test. Before the test, the first test area must be kept dry. Then, certain steps are carried out as follows:

[0048] First, apply 0.08 g of scalp protector to one side of the back of the ear. Place the scalp protector in the center of the 2 cm x 2 cm test area using a scraper, with the scraper at a 45-degree angle to the first test area. Gently spread the protector and slowly stretch it over all the sides, and evenly distribute the scalp protector over the first test area.

[0049] Next, apply 0.5 g of the inducing agent to the 2 cm x 2 cm area for the first test zone behind the ear. Place the inducing agent over the scalp protector using a scraper, with the scraper at a 45-degree angle to the first test zone. Gently spread the inducing agent and slowly stretch it out in all directions, distributing it evenly over the first test zone. The inducing agent can be any chemical composition likely to cause irritation or discomfort to the keratinous material.

[0050] Third, remove the scalp protectant and the inducing agent applied above respectively from the first test area within 5 min to 30 min, preferably within 5 min to 15 min after the first and second steps;

[0051] Fourth, obtain images of the first test area to obtain a plurality of first images and measure the first test area to obtain the transepidermal water loss values ​​of the keratinous material;

[0052] Fifth, process the plurality of first images by a processor to obtain the redness values ​​of the keratinous material;

[0053] Finally, evaluate the protective effect based on redness values ​​and transepidermal water loss values.

[0054] In addition, we can observe the redness values ​​and the transepidermal water loss values ​​on a display device, which allows the user to obtain a protection effect in a quicker and more accurate way.

[0055] To better assess the protective effect of a protective composition applied to a user's keratinous material, in one example, we can also consider certain subjective factors. For instance, after the third step, we can obtain the user's initial self-reported sensation information related to itching, burning, and tingling. Finally, the protective effect is evaluated based on redness values, transepidermal water loss values, and the initial self-reported sensation information. This allows for an objective evaluation combined with a subjective evaluation method for the protective composition.

[0056] Of course, we can also take an area of ​​the forearm as the first test area and the above steps are carried out.

[0057] In order to obtain a better protective effect compared to situations without a protective composition, [Fig. 3] shows a flowchart of a method 300 for evaluating the protective effect of a protective composition to be applied to a user's keratinous material according to a third embodiment of a first aspect of this disclosure. In one embodiment From [Fig. 3], a second test area is selected as a reference area. As shown in [Fig. 3], the left branch of procedure 300 comprises blocks 301, 302, 303, 304, and 305, which are the same as blocks 101, 102, 103, 104, and 105 shown in [Fig. 1]. Thus, blocks 301, 302, 303, 304, and 305 are not described in detail. As described in [Fig. 1], in block 304, the first test area is subjected to imaging to obtain a first parameter value, which may be a redness value; in block 305, the first test area is measured to obtain a second parameter value, which may be a transepidermal water loss value of the keratinized material. The execution order of blocks 304, 305 can be changed.

[0058] The right-hand branch in process 300 comprises blocks 30L, 303', 304', and 305'. Note that, in order to maintain consistent reference numbers in other figures, reference number 302' is not used. In block 301', the inducing agent that will cause redness and / or discomfort to the user's keratinous material is applied directly to the user's second test area. After a predetermined time period, the applied inducing agent is removed from the second test area indicated in block 303'. In one example, the predetermined time period could range from 5 to 30 minutes, preferably from 5 to 15 minutes. In block 304', the second test area is subjected to imaging by an imaging device to obtain a third parameter value.In one example, such an imaging device could be a camera, a mobile phone with imaging capabilities, a notepad computer with imaging capabilities, and so on. In one example, the third parameter value could be a redness value of the keratinous material for the second test area. At block 305', the second test area is measured to obtain a fourth parameter value. In one example, block 305' could be performed by a device to test the transepidermal water loss values ​​of the keratinous material, and the fourth parameter value could be a transepidermal water loss value of the keratinous material. The order in which blocks 304' and 305' are performed can be changed. Thus, the first and third parameter values ​​correspond to situations with and without a protective coating, respectively, and are related to the redness values ​​of the keratinous material.The second and fourth parameter values ​​correspond respectively to situations with and without a protective agent and are related to the transepidermal water loss values ​​of the keratinous material. In block 306, the protective effect is evaluated by comparing the first and third parameter values ​​and by comparing the second and fourth parameter values. In an example, it is possible to obtain the difference in the redness value between the two. first parameter value and third parameter value and the difference in change for transepidermal water loss values ​​between second parameter value and fourth parameter value, which can intuitively reflect the protective effect compared to situations without protective composition.

[0059] In order to obtain a better protective effect compared to situations without a protective composition, an objective evaluation combined with a method for subjectively evaluating the protective effect of a protective composition to be applied to a user's keratinous material is proposed. Figure 4 illustrates a flowchart of a method 400 for evaluating the protective effect of a protective composition to be applied to a user's keratinous material according to a fourth embodiment of a first aspect of this disclosure. In one embodiment of Figure 4, a second test area is selected as a reference area. As shown in Figure 4, the left branch of method 400 comprises blocks 401, 402, 403, 404, and 405, which are the same as blocks 201, 202, 203, 204, and 205 shown in Figure 2. Thus, blocks 401, 402, 403, 404, 405 are not described in detail. Similarly, as described in [Fig.[2] In block 404, the first test area is imaged to obtain a first parameter value, which may be a redness value for the keratinized material; in block 405, the first test area is measured to obtain a second parameter value, which may be a transepidermal water loss value of the keratinized material. The order of blocks 404 and 405 may be modified.

[0060] The right-hand branch in process 400 comprises blocks 40L, 403', 404', and 405'. Note that, in order to maintain consistent reference numbers in other figures, reference number 402' is not used. In block 401', the inducing agent that will cause redness and / or discomfort to the user's keratinous material is applied directly to a second test area of ​​the user. After a predetermined period of time, the applied inducing agent is removed from the second test area indicated in block 403'. In one example, the predetermined period of time may range from 5 to 30 minutes, preferably from 5 to 15 minutes. In block 405', the second test area is subjected to imaging by an imaging device to obtain a third parameter value. In one example, the third parameter could be a redness value of the keratinous material.In one example, such an imaging device could be a camera, a mobile phone with imaging capabilities, a notepad computer with imaging capabilities, and so on. At block 405', the second test area is measured to obtain a fourth parameter value. In one example, block 405' could be performed by a device to test transepidermal water loss of keratinized material. The fourth parameter value can be a transepidermal water loss value of the keratinous material. In block 406, the first self-perceived sensation information for the first test area is obtained from the user after the removal block 403. In block 406', the second self-perceived sensation information for the second test area is obtained from the user after the removal block 403'. The execution order of blocks 404, 405, and 406 can be changed. The execution order of blocks 404', 405', and 406' can be changed. In one example, the first and second self-perceived sensation information are related to itching, burning, and tingling.In block 407, the protective effect is evaluated based on comparisons between the first and third parameter values; between the second and fourth parameter values; and between the first and second self-reported sensations. In this document, the first and third parameter values ​​correspond to situations with and without the protective compound, respectively, and are related to redness values ​​for the keratinized material. The second and fourth parameter values ​​correspond to situations with and without the protective compound, respectively, and are related to transepidermal water loss values ​​for the keratinized material.In one example, it is possible to obtain the difference in redness value between the first and third parameter values, and the difference in transepidermal water loss values ​​between the second and fourth parameter values. Such differences in change, combined with self-perceived sensation information, can intuitively reflect the protective effect compared to situations without the protective compound, in terms of objective signs such as redness and subjective signs such as itching, burning, and tingling.

[0061] To better understand the technical solutions of processes 300 and 400, an embodiment will be given. In such an embodiment, we can take two areas behind the ear as the first and second test areas; and use a specific type of scalp protectant as the protective composition during the test. Before the test, the first and second test areas must be kept dry. Then, certain steps are carried out as follows:

[0062] First, apply 0.08 g of scalp protector to the first test area behind the ear, place the scalp protector in the center of the 2 cm x 2 cm test area using a scraper, the scraper being at a 45° angle degrees relative to the first test area. Gently spread the protector and slowly stretch it on all sides, and evenly distribute the scalp protector over the first test area.

[0063] Next, apply 0.5 g of the inducing agent to the 2 cm x 2 cm area for the first test zone behind the ear. Place the inducing agent over the scalp protector using a scraper, ensuring the scraper is at a 45-degree angle to the first test zone. Gently spread the inducing agent and slowly stretch it out in all directions, distributing it evenly over the first test zone. The inducing agent can be any chemical composition likely to cause irritation or discomfort to the keratinous material.

[0064] Furthermore, a step similar to the second step is performed in the second test area. Apply 0.5 g of inducing agent to the 2 cm x 2 cm area for the second test area behind the ear. The scraper is at a 45-degree angle to the second test area. Gently spread the inducing agent and slowly stretch it out in all directions, distributing the inducing agent evenly over the second test area.

[0065] Third, remove the scalp protectant and the inducing agent applied above from the first test area within 5 to 30 minutes, preferably within 5 to 15 minutes after the first and second steps. In addition, remove the inducing agent applied above from the second test area within 5 to 30 minutes, preferably within 5 to 15 minutes after the step similar to the second step;

[0066] Fourth, acquire images of the first test area to obtain a plurality of first images and measure the first test area to obtain the transepidermal water loss value of the keratinous material. Furthermore, acquire images of the second test area to obtain a plurality of second images and measure the second test area to obtain the transepidermal water loss value of the keratinous material.

[0067] Fifth, process the plurality of first and second images by a processor to obtain the redness values ​​of the keratinous material for the first test area and the second test area respectively;

[0068] Finally, evaluate the protective effect based on the results of comparing redness values ​​for the first test area and the second test area and the results of comparing transepidermal water loss values ​​for the first test area and the second test area.

[0069] Furthermore, we can observe the redness values ​​and transepidermal water loss values ​​for the first test area and the second test area in the form of a histogram on a display device of a computer device, which allows enabling the user to obtain a protective effect compared to situations without protective composition in an intuitive way.

[0070] To better assess the protective effect of a protective composition applied to a user's keratinous material, we can consider certain subjective factors. For example, after the third step, we can obtain the first and second self-reported sensations related to itching, burning, and tingling from the user. Finally, the protective effect is evaluated based on the results of comparing redness values ​​for the first and second test areas, comparing transepidermal water loss values ​​for the first and second test areas, and comparing the first and second self-reported sensations. This allows for an objective evaluation combined with a subjective evaluation method for the protective composition.

[0071] Of course, we can also take one area of ​​the forearm as the second test area or take two areas of the forearm as the first test area and second area and the above steps are carried out.

[0072] In an embodiment of a third aspect of the disclosure, we can obtain the protective effect of a plurality of different protector compositions more quickly and accurately. More specifically, we can select a plurality of test areas to which a plurality of different protector compositions are applied, and then apply the same inducing agent that will cause redness and / or discomfort to the user's keratinous material to the different protector composition applied. Then, removal, imaging, and measurement steps are performed on the plurality of test areas similar to the steps mentioned above. Thus, we will obtain a set of several parameter values ​​for each of the plurality of test areas.In one example, such parameter values ​​could be redness values ​​and transepidermal water loss values, displayed as a histogram on a computer display. Based on these parameter values ​​displayed on the display, we can obtain the protective effect of different sunscreen compositions more quickly, intuitively, and accurately. In practice, redness measurement and self-assessment are recommended on the back of the ear, while transepidermal water loss measurement is recommended on the forearm. In a preferred embodiment for this situation, each of the plurality of different sunscreen compositions is applied to each of a first plurality of test areas on the back of the user's ear and on the forearm. each of a second plurality of test areas on the user's forearm, respectively; the inducing agents that will cause redness and / or discomfort to the user's keratinous material are applied over each of the different protective compositions applied respectively; the different protective compositions applied and the inducing agents applied are removed from the first plurality of test areas and the second plurality of test areas, respectively; the first plurality of test areas is subjected to imaging by an imaging device to obtain a first plurality of parameter values; the second plurality of test areas by a device to test the transepidermal water loss value of the keratinous material is measured to obtain a second plurality of parameter values;and the protective effect is evaluated on the basis of the first plurality of parameter values ​​and the second plurality of parameter values. In one embodiment, the first plurality of parameter values ​​are redness values ​​of the keratinous material behind the ear; the second plurality of parameter values ​​are transepidermal water loss values ​​of the keratinous material on the forearm.

[0073] To better evaluate the protective effect of the plurality of protective compositions to be applied to a user's keratinous material, we can consider certain subjective factors. In one embodiment of the third aspect, we can obtain the plurality of self-perceived sensation information related to itching, burning, and tingling from the user for the plurality of test areas, which can be displayed as a percentage, as a histogram, or in another form on a display device. Finally, the protective effect is evaluated based on the results of comparisons of redness values ​​for the plurality of test areas, the results of comparisons of transepidermal water loss values ​​for the plurality of test areas, and the results of comparisons of the plurality of sensation information.It is thus possible to obtain an objective evaluation combined with a subjective evaluation method for the plurality of protector compositions. In practice, redness measurement and self-assessment are more recommended behind the ear. Thus, in a preferred embodiment for this situation, a first plurality of self-perceived sensation information for the first plurality of test areas from the user is obtained after the removal step of the different applied protector compositions and the applied inducing agents from the first plurality of test areas. The protective effect for a plurality of different protective products is evaluated based on the first plurality of parameter values, the second plurality of parameter values, and the first plurality of self-perceived sensation information. In one embodiment, the first plurality of... The first set of parameter values ​​represents redness of the keratinous material behind the ear; the second set of parameter values ​​represents transepidermal water loss of the keratinous material on the forearm. In one embodiment, the first set of self-perceived sensation information relates to itching, burning, and tingling.

[0074] In order to achieve a protective effect compared to no protective composition, in an embodiment for the third aspect, we also select a new test area as a test area without applying any protective composition. The inducing agent can be applied directly to such a new test area. Then, the removal, imaging, and measurement steps are performed on the new test area in a manner similar to the steps mentioned above. In addition, it is possible to obtain the redness values ​​and the transepidermal water loss value for the new test area, which can also be displayed as a histogram on a display device. Based on these parameter values ​​with and without the application of protective compositions, we can easily and quickly obtain protective effects compared to no protective composition.In a preferred example, the differences between these parameter values ​​with and without the application of protective compositions can be displayed on the display device. Observing such differences makes it easier to recognize the protective effect. In practice, measuring redness and self-assessment are more recommended on the back of the ear.Thus, in a preferred embodiment for this situation, the inducing agents are applied directly to a third test area on the back of the user's ear and to a fourth test area on the user's forearm; the applied inducing agents are removed from the third and fourth test areas after a predefined period of time such as 5 min to 15 min; the third test area is subjected to imaging by the imaging device to obtain a third parameter value; the fourth test area is measured by the device to test the transepidermal water loss of keratinous material to obtain a fourth parameter value; the protective effect is evaluated by comparing the first plurality of parameter values ​​and the third parameter values ​​and by comparing the second plurality of parameter values ​​and the fourth parameter value.In one embodiment, the first plurality of parameter values ​​and the third parameter value are redness values ​​of the keratinous material behind the ear; the second plurality of parameter values ​​and the fourth parameter value are transepidermal water loss values ​​of the keratinous material on the forearm.

[0075] In order to achieve a protective effect compared to no protective composition, in one embodiment for the third aspect, we also select a new test area as the test area without applying any protective composition. We can obtain self-perceived sensation information related to itching, burning, and tingling from the user for the new test area, which can be displayed as a percentage, as a histogram, or in another form on a display device. Then, the removal, imaging, and measurement steps are performed on the new test area in a manner similar to the steps mentioned above. In addition, it is possible to obtain the redness values ​​and the transepidermal water loss value for the new test area, which can also be displayed as a histogram on a display device.Based on these parameter values ​​obtained with and without the application of protective compositions, we can easily and quickly achieve protective effects compared to no protective composition at all. In a preferred example, the differences between these parameter values ​​obtained with and without the application of protective compositions and the results of comparisons between certain self-perceived sensations can be displayed on the display device. Observing such differences makes it easier to recognize the protective effect. In practice, measuring redness and self-assessment are particularly recommended on the back of the ear.Thus, in a preferred embodiment for this situation, a third self-perceived sensation information for the third test area is also obtained after the step of removing the applied inducing agent from the third test area; wherein the evaluation step also includes the evaluation of the protective effect by comparing the first plurality of parameter values ​​and the third parameter values; by comparing the second plurality of parameter values ​​and the fourth parameter value; and by comparing the first plurality of self-perceived sensation information and the third self-perceived sensation information.In one embodiment, the first plurality of parameter values ​​and the third parameter values ​​are redness values ​​of the keratinous material behind the ear; the second plurality of parameter values ​​and the fourth parameter value are transepidermal water loss values ​​of the keratinous material on the forearm. In another embodiment, the first plurality of self-perceived sensation information and the third self-perceived sensation information are information related to itching, burning, and tingling.

[0076] In the context of the disclosure, the quantities of protector composition and inducing agent to be applied and the size of the test area are given only to These values ​​are given as an example and are not limited to the aforementioned values. Preferably, the protective composition is applied at a rate of approximately 0.01 g–0.1 g / cm² and the inducing agent is applied at a rate of approximately 0.01 g–1 g / cm².

[0077] Figure 5 illustrates a schematic diagram of a computer device 500 for evaluating the protective effect of a protective composition to be applied to a user's keratinous material in accordance with a second aspect of this disclosure.

[0078] The computing device 500 comprises an imaging device 501, a measuring unit 502, and a processor 503. The imaging device 501 includes a set of computing circuits configured to obtain images of a first test area of ​​the user's keratinous material to obtain a plurality of first images. The measuring unit 502 includes a set of computing circuits configured to measure the first test area to obtain a second parameter value. The processor 503 includes a set of computing circuits configured to obtain a first parameter value for the first test area and evaluate the protective effect based on the first and second parameter values.

[0079] Before proceeding with imaging the first test area, several steps are performed. First, a protective composition is applied to the first test area of ​​the user's keratinous material. In the context of disclosure, the protective composition may be a product designed to protect the user's keratinous material. For example, the test area could be the back of the ear, the forearm, or any other area of ​​the user's body. Next, an inducing agent that will cause redness and / or discomfort to the user's keratinous material is applied over the applied protective composition. The inducing agent may be one with a high pH ingredient that is likely to induce redness and discomfort in the keratinous material.Next, the applied protective composition and the applied inducing agent are removed from the first test area within a predefined time period after application of the inducing agent. For example, the predefined time period could range from 5 to 30 minutes, preferably from 5 to 15 minutes. Such an imaging device could be a mobile phone with imaging capabilities, a laptop computer with imaging capabilities, and so on. The unit of measurement could be a device for testing the transepidermal water loss (TEWL) value of keratinized material, and the second parameter value could be a TEWL value of keratinized material. More specifically, the images are processed to obtain the redness value of the keratinized material. Such a computer-based device allows for the rapid and objective acquisition of a [missing information - likely a specific effect or effect]. protection such as in the form of redness and discomfort from the protective composition for keratinous material.

[0080] In order to better evaluate the protective effect of a protective composition to be applied to a user's keratinous material, the disclosure relates to an objective evaluation combined with a method for subjectively evaluating the protective effect of a protective composition to be applied to a user's keratinous material. In one example, the processor 503 includes a set of computing circuits configured to also receive first self-perceived sensation information for the first test area from the user after the applied composition and the applied inducing agent have been removed from the first test area; and to evaluate the protective effect based on the first parameter value, the second parameter value, and the first self-perceived sensation information.In one example, the first parameter value is related to the redness value and the second parameter value is related to the transepidermal water loss value. In another example, the first self-perceived sensation information is related to itching, burning, and tingling.

[0081] In order to obtain a better protective effect compared to situations without a protective composition, in one embodiment, a second test area is selected as a reference area, and the agent that will cause redness and / or discomfort to the user's keratin is applied directly to this second test area. After a predefined period of time, the applied inducing agent is removed from the second test area. In one example, the predefined period of time may range from 5 to 30 minutes, preferably from 5 to 15 minutes. The second test area is then imaged by an imaging device 501 to obtain a plurality of first images. The processor 502 processes the images for the second test area to obtain a third parameter value.In one example, such an imaging device 501 could be a camera, a mobile phone with imaging capabilities, a notepad computer with imaging capabilities, and so on. Next, the second test area is measured to obtain a fourth parameter value using a measuring unit 502, such as a device for testing the transepidermal water loss value of keratinous material. The fourth parameter value could be a transepidermal water loss value of keratinous material. In this document, the first and third parameter values ​​correspond respectively to situations with and without a protective composition and are related to redness values. The second and fourth parameter values ​​also correspond respectively to situations with and without a protective composition and are related to the transepidermal water loss values ​​of keratinous material. The 503 processor is configured to evaluate the protective effect by comparing the first parameter value with the third parameter value, and by comparing the second parameter value with the fourth parameter value. For example, it is possible to obtain the difference in redness value between the first and third parameter values, and the difference in transepidermal water loss values ​​between the second and fourth parameter values, and display them as a histogram on a computer display. This allows for an intuitive comparison of the protective effect with situations where no protective agent is applied.

[0082] In order to obtain a better protective effect compared to situations without a protective composition, an objective evaluation combined with a subjective evaluation method of the protective effect of a protective composition to be applied to a user's keratinous material is proposed. In one example, a second test area is selected as a reference area.

[0083] The inducing agent, which will cause redness and / or discomfort to the user's keratinous material, is applied directly to the user's second test area. After a predefined period of time, the applied inducing agent is removed from the second test area. In one example, the predefined period of time could range from 5 to 30 minutes, preferably from 5 to 15 minutes. Next, the second test area is imaged by an imaging device 501 to obtain a plurality of second images for the second test area. The processor 503 processes the plurality of second images to obtain a third parameter value.The second test area is measured to obtain a fourth parameter value using a 502 unit of measurement, such as a device for testing the transepidermal water loss (TEWL) of keratinized material. The first self-reported sensation information for the first test area is obtained from the user after removing the applied protective composition and the applied inducing agent from the first test area. The second self-reported sensation information for the second test area is obtained from the user after removing the applied inducing agent from the second test area. In one example, the first and second self-reported sensations are related to itching, burning, and tingling.In this document, the first and third parameter values ​​correspond respectively to situations with and without a protective coating and are related to the redness values ​​for the keratinous material. The second and fourth parameter values ​​correspond respectively to... Situations with and without the protective compound are related to the transepidermal water loss values ​​of the keratinous material. In one embodiment, the 503 processor is also configured to evaluate the protective effect based on comparisons between the first and third parameter values; between the second and fourth parameter values; and between the first and second self-perceived sensation information. For example, it is possible to obtain the difference in redness value between the first and third parameter values ​​and the difference in transepidermal water loss values ​​between the second and fourth parameter values.Such differences in change combined with self-perceived sensation information can intuitively reflect the protective effect compared to situations without protective composition in terms of objective signs such as redness and subjective signs such as itching, burning and tingling.

[0084] The computing device 500 can be, for example, a service provider's server, a customer-associated device (e.g., a client device), a system-on-a-chip, and / or any other suitable computing device or computer system. In various implementations, the computing device 500 can take on a variety of different configurations. For example, the computing device 500 can be implemented as a computer-like device, including a personal computer, a desktop computer, a multi-monitor computer, a laptop computer, a mini-laptop computer, and others. The computing device 500 can also be implemented as a mobile-like device, including mobile devices such as mobile phones, portable music players, portable gaming devices, tablets, multi-monitor computers, and others.The 500 computing device can also be implemented as a television-like device that includes a device with a generally larger screen in a casual viewing environment or connected to it. These devices include televisions, set-top boxes, game consoles, and others.

[0085] In one embodiment, the computing circuitry comprises, among other things, one or more computing devices such as a processor (for example, a microprocessor, a quantum processor, a qubit processor, etc.), a central processing unit (CPU), a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), and others, or any combination thereof, and may include elements or Discrete digital or analog electronic components, or combinations thereof. In one embodiment, the computing circuitry comprises one or more ASICs having a plurality of predefined logic components. In another embodiment, the computing circuitry comprises one or more FPGAs, each having a plurality of programmable logic components.

[0086] In one embodiment, the computing circuit assembly comprises one or more electrical circuits, printed circuits, flexible circuits, electrical conductors, electrodes, cavity resonators, conductive traces, ceramic pattern electrodes, electromechanical components, transducers, and others.

[0087] In one embodiment, the computing circuit set comprises one or more components operationally coupled (for example, coupled communicatively, electromagnetically, magnetically, ultrasonically, optically, inductively, electrically, capacitively, wirelessly, and so on) to each other. In one embodiment, the circuit set comprises one or more components located at a distance. In one embodiment, the components located at a distance are operationally coupled, for example, via wireless communication. In one embodiment, the components located at a distance are operationally coupled, for example, via one or more communication modules, receivers, transmitters, transceivers, and so on.

[0088] In one embodiment, the computing circuitry includes a memory that, for example, stores instructions or information. Non-limiting examples of memory include volatile memory (e.g., random access memory (RAM), dynamic random access memory (DRAM), and others), non-volatile memory (e.g., read-only memory (ROM), electrically erasable read-only memory (EEPROM), compact disc read-only memory (CD-ROM), and others), persistent memory, and others. Other non-limiting examples of memory include erasable and programmable read-only memory (EPROM), flash memory, and others. In one embodiment, the memory is coupled, for example, to one or more computing devices by one or more instructions, information, or power buses. In one embodiment, the computing circuitry includes one or more databases stored in memory.In one embodiment, the set of calculation circuits includes one or more lookup tables stored in memory.

[0089] In one embodiment, the computing circuitry includes one or more computer-readable media players, interface jacks, universal serial bus (USB) ports, memory card slots and other ports, and one or more input / output components such as, for example, a graphical user interface, a display device, a keyboard, a numeric keypad, a ball joint control, a joystick, a touch screen, a mouse, a switch, a dial and others, and any other peripheral device. In one embodiment, the computing circuitry set includes one or more user input / output components that are operationally coupled to at least one computing device configured to control (electrical control, electromechanical control, software implementation, firmware implementation or other control, or combinations thereof) at least one parameter associated, for example, with the determination of one or more tissue thermal properties reactive to detected shifts in the ignition voltage.

[0090] In one embodiment, the computing circuitry comprises a set of electrical circuits forming a universal computing device configured by a computer program (for example, a universal computer configured by a computer program that at least partially implements the methods and / or devices described in this document, or a microprocessor configured by a computer program that at least partially implements the methods and / or devices described in this document), a set of electrical circuits forming a memory device (for example, forms of memory (e.g., random access, flash, read-only, etc.)), a set of electrical circuits forming a communication device (e.g., a modem, a communication switch, optical-electrical equipment, etc.), and / or any non-electrical analog thereof, such as an optical or other analog.

[0091] One embodiment of the disclosure may be a manufactured article in which a machine-readable, non-transient medium (such as microelectronic memory) on which instructions (e.g., computer code) are stored is programmed to perform the operations described above. In other embodiments, some of these operations may be performed by specific hardware components that contain hardwired logic (e.g., dedicated digital filter blocks and state machines). Alternatively, these operations may be performed by any combination of programmed data processing components and fixed hardwired circuit components.

[0092] Although embodiments have been illustrated and described in this document, it will be understood by those skilled in the art that various changes and modifications can be made, and equivalents can be substituted for elements thereof, without departing from the true scope of the present technology. Furthermore, numerous modifications can be made to suit a particular situation and the present teaching without departing from its core purpose. Therefore, it is intended that the present embodiments are not limited to the particular embodiment disclosed as being the best envisaged way to implement the present technology, but that the present embodiments include all embodiments within the scope of the attached claims.

Claims

Demands

1. A method for evaluating the protective effect of a protective composition to be applied to a user's keratinous material, the method comprising the following steps: - application of the protective composition to a first test area of ​​the user's keratinous material; - application of an inducing agent that will cause redness and / or discomfort to the user's keratinous material over the applied protective composition; - removal of the applied protective composition and the applied inducing agent from the first test area; - imaging of the first test area by an imaging device to obtain a first parameter value; - measurement of the first test area by a device to test the transepidermal water loss value of the keratinous material to obtain a second parameter value;and - evaluation of the protective effect based on the first parameter value and the second parameter value.;

2. A method according to claim 1, also comprising the following steps: - obtaining from the user a first self-perceived sensation information for the first test area after the step of removing the applied protector composition and the applied inducing agent from the first test area; and - evaluating the protective effect on the basis of the first parameter value, the second parameter value and the first self-perceived sensation information.

3. A method according to claim 1, further comprising the following steps: - direct application of the inducing agent to a second user test area; - removal of the applied inducing agent from the second test area; - imaging of the second test area by the imaging device to obtain a third parameter value; - measurement of the second test area by the device to test the transepidermal water loss of keratinous material to obtain a fourth parameter value; and - evaluation of the protective effect by comparing the first parameter value and the third parameter value and by comparing the second parameter value and the fourth parameter value.

4. A method according to claim 3, further comprising the following steps: - obtaining a first self-perceived sensation information for the first test area after the step of removing the applied protective composition and the applied inducing agent from the first test area; and - obtaining a second self-perceived sensation information for the second test area from said user after the step of removing the applied inducing agent from the second test area; wherein the evaluation step also comprises evaluating the protective effect based on the results of comparison between the first parameter value and the third parameter value, the results of comparison between the second parameter value and the fourth parameter value; and the result of comparison between the first self-perceived sensation information and the second self-perceived sensation information.

5. Method according to claim 3 or 4, wherein the first test area and the second test area may be one of the back of the ear, the forearm and any area of ​​keratinous material.

6. A method according to any one of claims 1 to 4, wherein the first parameter value and the third parameter value are redness values ​​of the keratin material; the second parameter value and the fourth parameter value are transepidermal water loss values ​​of the keratin material.

7. A method according to claims 2 and 4, wherein the first self-perceived sensation information and the second self-perceived sensation information are information related to itching, burning, and tingling.

8. A computer device for evaluating the protective effect of a protective composition to be applied to a user's keratinous material, comprising: - an imaging device having a set of computing circuits configured to obtain images of a first test area of user keratin material to obtain a plurality of first images; - a measurement unit comprising a set of computing circuits configured to measure the first test area to obtain a second parameter value by testing the transepidermal water loss value of the keratin material; - a processor comprising a set of computing circuits configured to process the plurality of first images for the first test area to obtain a first parameter value and evaluate the protective effect based on the first and second parameter values.

9. A method for evaluating the protective effect of a plurality of different protective compositions to be applied to a user's keratinous material, the method comprising the steps of: - applying each of the plurality of different protective compositions to each of a first plurality of test areas on the back of the user's ear and to each of a second plurality of test areas on the user's forearm respectively; - applying inducing agents that will cause redness and / or discomfort to the user's keratinous material over each of the different protective compositions applied respectively; - removing the different protective compositions applied and the inducing agents applied respectively from the first plurality of test areas and the second plurality of test areas;- Imaging of the first plurality of test areas by an imaging device to obtain a first plurality of parameter values; - Measurement of the second plurality of test areas by a device to test the transepidermal water loss value of the keratinous material to obtain a second plurality of parameter values; and - Evaluation of the protective effect based on the first plurality of parameter values ​​and the second plurality of parameter values.

Images