Correction of the measurement of an analyte concentration
By integrating a motion measurement module to correct for device movements, the method improves the accuracy of analyte concentration measurements in wearable devices, addressing the issue of measurement noise from user movements.
Patent Information
- Authority / Receiving Office
- FR · FR
- Patent Type
- Patents
- Current Assignee / Owner
- WIZP AS
- Filing Date
- 2022-08-26
- Publication Date
- 2026-06-19
Smart Images
Figure 00000015_0000 
Figure 00000015_0001 
Figure 00000015_0002
Abstract
Description
Title of the invention: Correction of the measurement of an analyte concentration technical field
[0001] The invention relates to a method for measuring the concentration of an analyte contained in a body fluid of an individual and preferably of the glucose contained in the interstitial fluid of an individual.
[0002] The invention finds particular application for wearables such as portable patches or electronic watches or electronic bracelets used daily for real-time monitoring of the blood glucose of a diabetic patient or other bodily analyte. STATE OF THE ART
[0003] Certain pathologies such as diabetes require daily monitoring of biochemical parameters of the human body, i.e. concentrations of certain compounds (blood sugar in the example of glucose).
[0004] Devices with microneedles, such as a watch, are known and have the advantage of being less invasive than conventional needles, such as the one described in document WO2018104647, which comprises a case containing a removable capsule. The capsule houses microneedles configured to collect interstitial fluid. The case itself contains most of the electronics. These devices can be portable and typically attached to a user's wrist.
[0005] It is known to measure the concentration of an analyte using an electrochemical sensor. Such a sensor makes it possible to convert information relating to a chemical reaction into an electrical signal. As such, the sensor comprises at least one working electrode coated with a material capable of reacting with the analyte.
[0006] A known technique for measuring the quantity of analyte using an electrochemical sensor is amperometric measurement. This technique involves energizing the working electrode to induce a chemical reaction at the electrode; the current flowing through the electrode is measured and depends on the analyte concentration.
[0007] But amperometric measurement must be able to measure the quantity of analyte with the greatest possible precision, particularly when it comes to measuring glucose in diabetic users.
[0008] However, despite the use of various support devices, such as a bracelet, to hold the device with microneedles and a sensor on the user's wrist, disturbances exist.
[0009] Indeed, as ready-to-wear devices, they are subject to movements of the user (of the wrist, hand or other depending on where the device is positioned).
[0010] These movements displace the microneedle device and therefore cause the microneedles to move. For example, picking up a mobile phone and writing a text message causes the user's wrist to rotate and thus the watch on their wrist to move.
[0011] The movement of the microneedles is detrimental to the accuracy of the measurement because it induces fluctuations in the amperometric measurement which are not a reflection of an evolution of the concentration in the analyte being measured but of the position of the microneedle.
[0012] Unfortunately, it is difficult to ensure the positioning of a ready-to-wear device while avoiding these noise phenomena induced by the residual movements of the wearer which cause this device to move. Description of the invention
[0013] The invention proposes to overcome at least one of these drawbacks.
[0014] To this end, the invention proposes, according to a first aspect, a method for measuring the concentration of at least one analyte by means of an analyte concentration monitoring device comprising an analyte measurement sensor and a motion measurement module for the monitoring device, the monitoring device comprising a processing unit connected to the sensor and the motion measurement module, the monitoring device being in contact with a limb of a user, the method comprising the following steps implemented by the processing unit:
[0015] - measurement of at least one analyte concentration using the sensor;
[0016] - determination of a movement of the monitoring device by means of the module motion measurement;
[0017] - correction of the analyte concentration measurement as a function of the movement of the monitoring system thus determined.
[0018] The invention is advantageously complemented by the following features, taken alone or in any technically possible combination thereof:
[0019] - the sensor of the monitoring device is a microneedle sensor;
[0020] - the motion measurement module comprising a gyroscope, the motion determined being a rotational movement of the monitoring device over time;
[0021] - the correction of the rotational movement of the monitoring device is carried out for a rotational movement of at least 20°, preferably between 90° and 180° measured from a reference position;
[0022] - the method includes a calibration step of the monitoring device, the ca libration including a determination of the reference position and which corresponds to a constrained positioning of the user's limb in a particular position;
[0023] - the motion measurement module comprising an accelerometer, so as to determine an acceleration movement of the monitoring device over time;
[0024] - the motion measurement module and the sensor are configured to perform their respective measurements of concentration and movement in a successive manner, the measurements including data of movement, analyte concentration, time and space;
[0025] - the analyte movement and concentration measurements are carried out at different or equal frequencies, the motion measurement module and the sensor being synchronized on the same time base;
[0026] - each measurement frequency is variable depending on the measurements of the movement and / or external parameters specific to the user.
[0027] The invention proposes, according to a second aspect, a microneedle device comprising a processing unit configured to implement a process according to the first aspect of the invention.
[0028] Thus, the invention makes it possible to overcome the measurement noise problems induced by the inevitable residual movements of the device on the user's limb.
[0029] Furthermore, the invention takes into account different types of different noise in order to combine the induced noise and correct the measurement more precisely.
[0030] The invention allows the user to obtain a reliable analyte concentration measurement despite the movements of his / her limb(s). DESCRIPTION OF THE FIGURES
[0031] Other features, objectives and advantages of the invention will become apparent from the following description, which is purely illustrative and not limiting, and which should be read in conjunction with the accompanying drawings on which:
[0032] - Fig. 1 schematically illustrates a monitoring device according to a mode of realization;
[0033] - Figures [Fig. 2A] and [Fig. 2B] illustrate the steps of a method for measuring a analyte concentration according to different embodiments;
[0034] - Figure 3 schematically illustrates a device according to one embodiment positioned on a user's limb and subject to movements;
[0035] - Figure 4 schematically illustrates a device according to one embodiment positioned on a user's limb and subject to other movements;
[0036] - Figure 5 schematically illustrates a device according to one embodiment positioned on a user's limb and subject to other movements;
[0037] - Fig. 6 illustrates a curve representing an example of correction of the concentration;
[0038] - Figure 7 illustrates one embodiment of a monitoring device according to the invention.
[0039] Throughout the figures, similar elements bear identical references. DETAILED DESCRIPTION OF THE INVENTION
[0040] Figure 1 illustrates a device 1 for measuring a user's physiological parameter. The monitoring device 1 is designed to be attached to a user's limb. The monitoring device 1 can be attached to the arm or wrist, depending on the parameter to be measured. More generally, the monitoring device 1 is positioned on a limb of the user.
[0041] By physiological quantity is meant any physical, chemical and / or biological quantity representative of a state of the user's body; hereafter, the focus will be on the concentration of bodily analytes. Preferably, the analytes detected are glucose and / or lactate.
[0042] Such a monitoring device 1 is therefore preferably a monitoring device 1 of body analyte in an interstitial fluid.
[0043] As illustrated in [Fig.1], the device 1 comprises a sensor 2 configured to measure the analyte concentration, a motion measurement module 3 of the monitoring device 1 and a processing unit 4 connected to the sensor 2 and the measurement module 3. The monitoring device 1 is advantageously in a single module but can be made up of several different modules such as for example a patch and a housing or several housings, communicating with each other.
[0044] The monitoring device 1 also includes at least one motion measurement module 3 for the monitoring device 1. The motion of the monitoring device 1 is generally induced by the movement of the user's limb on which the monitoring device 1 is positioned. The measurement module 3 makes it possible to determine the evolution of the position of the monitoring device 1 in space and thus to obtain data on the movement of the monitoring device 1 relative to the user's limb.
[0045] According to one embodiment, the measurement module 3 includes a gyroscope 31 and / or an accelerometer 32 whose functions will be explained below.
[0046] The monitoring device 1 also includes a processing unit 4 connected to the sensor 2 and the measuring module 3. The processing unit 4 is configured to receive data from the sensor 2 and data in The measurement module 3 provides the data. The processing unit 4 centralizes the measured information in order to process it and provide a result. Preferably, the processing unit 4 outputs a measurement of the analyte concentration, denoted CA, as a function of the movement data of the monitoring device 1, as determined by the measurement module 3. In one embodiment, the monitoring device 1 includes a display unit 5, and / or other means of transmitting information or signals to the user. In particular, the display unit 5 allows the user to know, in real time, the analyte concentration CA resulting from the processing applied by the processing unit 4.
[0047] In addition, the data from the measurements can be transmitted from the sensor 2 and the measuring module 3 to the processing unit 4 electrically, preferably by transmitting an electrical signal in electrodes connecting them to the processing unit 4. The data can also be transmitted by electromagnetic waves, when the sensor 2 and the measuring module 3 are equipped with an electromagnetic wave transmitter and the processing unit 4 is equipped with an electromagnetic wave receiver.
[0048] The monitoring device 1 described above, according to one embodiment, is adapted to be worn by a user. Preferably, the user wears such a monitoring device 1 on a limb, such as the arm or leg, and for example on the wrist. However, the inevitable movements of the user's limb during the day and night induce movement of the monitoring device 1. The measurement of the analyte concentration CA therefore includes noise related to the movement of the monitoring device 1 relative to the user's limb.
[0049] Therefore, when the monitoring device 1 is attached to the user's limb, the movements of his limb are advantageously taken into account in a measurement method described below.
[0050] In relation to [Fig.2A] a measurement method includes steps to take into account the movements of the user's limb involving rotational movements, noted MR and acceleration movements noted MA of the monitoring device 1. The monitoring device 1 of an analyte concentration CA comprising a sensor 2 and a measurement module 3 of the movement of the monitoring device is attached or brought into contact with a limb of a user during a pre-positioning step E0.
[0051] In this respect and advantageously, the monitoring device 1 includes attachment means 230 for attaching it to the user's body. The attachment means 230 limit the movement of the monitoring device 1 relative to the user's limb. Alternatively, the monitoring device 1 can be in contact with a user's limb in various ways, such as being stuck if it is a patch or plated.
[0052] Once attached to the user's limb, the method includes a measurement step El of an analyte concentration CA using sensor 2.
[0053] Preferably, the measurement El of the analyte concentration CA is performed periodically at a first frequency by the sensor 2. Several measurements are then available, performed periodically at this first frequency at different times. Advantageously, this first frequency is variable according to external parameters such as the results of the previous measurement, the user's physical state, and / or the time of day. In other words, this first measurement frequency can be adjusted over time.
[0054] The first frequency is, for example, 1 to 15 measurements every 1 to 15 minutes, preferably 1 measurement every 1 to 3 minutes, or 10 measurements every 1 to 15 minutes, preferably every 1 to 3 minutes, depending on the case. It should be noted that the measurement frequency of the analysis increases when entering critical zones (risk of hypoglycemia or hyperglycemia when the analyte is glucose).
[0055] The method also includes a step E2 of determining the movement of the monitoring device 1 by means of the motion measurement module 3. The motion measurement module 3 determines the characteristics of the movement undergone by the monitoring device 1. Preferably, the measurement module 3 determines all movements displacing the monitoring device 1 in space.
[0056] According to one embodiment, the measuring module 3 includes a gyroscope so as to determine, during the determination step E2, a rotational movement MR of the monitoring device 1 over time.
[0057] According to another embodiment, the measuring module 3 includes an accelerometer so as to determine, during the determination step E2, an acceleration movement MA of the monitoring device 1 over time.
[0058] According to another preferred embodiment, the measuring module 3 includes a gyroscope and an accelerometer so as to be able to determine the most complex movements of the measuring device 1 combining rotations MR and / or accelerations MA.
[0059] The motion determination step E2 allows for the consideration, in real time or near real time, of movements of the monitoring device 1 in space, and therefore its displacement, which can introduce noise into the analyte measurement. Preferably, the measurement module 3 determines the movements periodically and at a second frequency. Measurements of the movement taken at several times at this second frequency are then available.
[0060] Advantageously, this second frequency is also variable depending on external parameters such as the results of the previous measurement, the physical state of the user and / or the time of day. Indeed, it is understood that if a rapid movement is detected (when the user is in physical activity for example) the measurement of the movement will have to be done at a rapid frequency to take into account the entire duration of the movement and correct a measurement of the analyte concentration that would have been carried out during this movement (see below).
[0061] The measurement module 3 sends the measured data to the processing unit 4 in order to process the measurements of the physiological quantity made by the sensor 2 according to the movement data, the sensor 2 having also sent the measured data to the processing unit 4.
[0062] The method then includes a correction step E3, using the processing unit 4, of the measurement of the analyte concentration CA performed by the sensor as a function of the movement of the monitoring device 1 determined by the measuring module 3. The processing unit 4 thus combines the measurements of the physiological quantity performed by the sensor 2 with the movement measurements determined by the measuring module 3 and ensures that the combined data from the sensor 2 and the measuring module 3 correspond to data measured at identical or near times. To this end, the measuring module 3 and the sensor 2 are synchronized to the same time base to ensure that the measurements are matched.
[0063] Indeed, the measurement frequency of the analyte and the measurement frequency of the motion may be different, so that the E3 correction of the analyte measurement will take into account a motion measurement that coincides
[0064] The correction E3 of the analyte concentration measurements CA is performed by the processing unit 4 based on the movements determined by the measuring module 3. This correction is carried out in real time within the processing unit 4 to ensure that it modifies the concentration measurement according to the movement detected at the time of the measurement. Alternatively, it is possible to take into account data measured by the sensor 2 and the module 3 at different time intervals or which have temporal overlaps.
[0065] The correction step E3 allows the measurement of the analyte concentration CA to be modified in order to remove noises from the movements of the monitoring device which induce a displacement of the device relative to the user's limb.
[0066] The E3 correction is preferably performed when an analyte measurement is taken during time periods in which a movement that could affect the measurement is being recorded. For this purpose, the analyte measurement taken during the measurement period of the movement will be used for the correction.
[0067] Preferably, the steps of the process are carried out at a variable frequency. Indeed, it is advantageous to adapt the frequency of measurement of the analyte concentration CA and of the determination of the movement to the external conditions and to the results of the measurements themselves.
[0068] For example, the frequency may depend on the time of day: whether the user is asleep or in a particular position. Furthermore, it is advantageous to vary the measurement and / or motion determination frequency according to the movement being determined; for example, the greater or more specific the movement determined by measurement module 3, the more effectively increasing the measurement frequency E1 and E2 helps to suppress noise.
[0069] It is therefore possible to determine the analyte concentration CA continuously over time, for example, to monitor it or to initiate interaction with the user. The correction of the analyte concentration CA during step E3 can indeed be performed using measurements from sensor 2 and module 3 taken simultaneously. In this case, sensor 2 and module 3 are assumed to measure the data at the same frequency.
[0070] According to one embodiment, illustrated in [Fig. 2B], the method includes a calibration step E01. The calibration step consists of positioning the monitoring device 1 attached to the user's limb in a specific position. To do this, after the positioning step E0, the user places their limb in a specific position to allow the monitoring device 1 to acquire the spatial characteristics of that position. For example, in the embodiment in which the monitoring device 1 is positioned on the user's wrist, a reference position could be placing their hand flat on a table so that the wrist-attached device is oriented vertically above the ground and stationary. The calibration step allows a so-called reference position to be recorded, from which the movements of the monitoring device 1 will be determined E2.The reference position is then used as a reference point during the process steps in order to correct signal noise caused solely by device movements.
[0071] According to one embodiment, it is possible to define margins or thresholds for movement amplitude. That is to say, the E3 correction is only triggered from or up to certain movement values.
[0072] For example, the processing unit is optionally set to correct the concentration measurement only when the rotational movement (MR) exceeds a defined angle. In one embodiment, the rotational movement (MR) that triggers a correction of the analyte concentration measurement (CA) is a rotational movement (MR) of at least 20° beyond the reference position. Advantageously, the range of rotational movement (MR) that induces a processing and correction step for the concentration measurement is between 20° and 180° beyond the reference position. The rotational movements (MR) are determined relative to the reference position and in all possible directions around this reference position.
[0073] The same applies to the correction of the concentration as a function of rotational movements corresponding to ranges of value which depend on many different parameters such as the sensitivity of sensor 2, the noise level, the enzyme and the analyte in question, the weight of the monitoring device 1 and other characteristics taken into account to set thresholds.
[0074] Certain activities, for example sports activities, induce complex movements. These complex movements, such as those of a tennis player's arm, are rotational (MR) and accelerated (MA) movements. They therefore create displacements of the monitoring device 1 relative to the user's limb that are rotational and / or accelerated. These movements, performed independently or in combination, set the monitoring device 1 in motion on the user's limb on which it is positioned.
[0075] Indeed, as illustrated in [Fig. 3], the monitoring device 1 is subjected to multiple rotational movements MR due to the user's arm movements. For example, when the user turns their arm towards their face to check the time, or when they bend their wrist relative to their arm to grasp an object, or when they rotate their wrist to type a message on their mobile phone, the device 1 is set in rotation and experiences forces that can cause it to move relative to the user's limb. Gravity, in certain cases, increases the displacement of the monitoring device 1. Under these conditions, the rotational movements MR create disturbances in the measurement performed by the sensor 2.
[0076] Furthermore, as illustrated in [Fig. 4], in certain situations the user is led to make movements that are sometimes abrupt, involving acceleration of their limbs and therefore of the monitoring device 1 attached to a limb. For example, when a user runs, the movements of their limbs are acceleration movements MA. The forces induced by these movements on the monitoring device 1 worn by the user cause it to move. The acceleration movements MA thus create conditions that disrupt the measurement performed by the sensor.
[0077] Finally, it is possible that certain activities, for example sports activities, induce complex movements and / or impacts resulting in significant accelerations. These critical movements, such as those of a tennis player's arm illustrated in [Fig. 5], are rotational (MR) and accelerated (MA) movements. They therefore create displacements of the monitoring device 1 relative to the user's limb that are rotational and / or accelerated. For example, when receiving a tennis ball, the racket is violently struck, and this impact is transmitted to the wrist. This results in a strong acceleration that can displace the monitoring device 1 relative to the limb.
[0078] These movements, performed independently or in combination, set the monitoring device 1 in motion on the user's limb with which it is in contact. These movements therefore generate disturbances in the measurement of the analyte concentration CA.
[0079] Figure 6 illustrates superimposed curves representing the motion measured by the measuring module 3 and the analyte concentration CA. The first superposition of curves represents the measurement results from the measurement step E1 and the determination step E2 as a function of time. The second superposition of curves represents the measurement results after the correction step E3, with the analyte concentration CA being corrected as a function of the motion M of the monitoring device 1.
[0080] Preferably, the sensor allows the concentration of analyte CA in the user's interstitial fluid to be measured without causing pain to the user. Such a sensor is illustrated in [Fig. 7], which further represents a monitoring device 1 according to one embodiment. The sensor 2 comprises a plurality of microneedles 10 adapted to be inserted into the user's dermis and a plurality of electrodes, each electrode comprising a metallic surface arranged on the surface of a microneedle and also comprising biomolecules covering the active surface. Each electrode is adapted to measure the concentration of analyte CA in the user's interstitial fluid by an electrochemical reaction between the biomolecule and the analyte. Thus, it is possible to measure the concentration of the analyte in the user's interstitial fluid.Optionally, the analyte detected by the electrodes can be selected by choosing a biomolecule suitable for recognizing that analyte, preferably electrochemically. Preferably, the analytes detected are glucose and / or lactate. A material suitable for reacting with the body analyte is, for example, an enzyme capable of oxidizing the body analyte. The electrode preferably includes a coating, the coating comprising the biomolecules. The coating is configured to allow electrochemical measurement of the concentration of the CA analyte in the interstitial fluid within a predetermined CA analyte concentration range.
[0081] According to one embodiment, the monitoring device 1 is a watch. Figure 7 illustrates the monitoring device 1 according to this embodiment. Such a body monitoring device 1 comprises a housing 200, a sensor 2, and an adhesive patch 40.
[0082] The sensor 2 is here a needle sensor intended to provide an electrical current measurement within the interstitial fluid of the wearer of the monitoring device 1.
[0083] The motion measurement module is advantageously arranged in the housing 200.
[0084] Needles 10 are advantageously arranged on an inner face 21 of the sensor 2. This inner face 21 is intended to be placed on the skin of the wearer.
[0085] The sensor 2 is assembled to the adhesive patch 40 and together they form a capsule. The sensor 2 can also be removable from the patch 40. Such a capsule is advantageously mounted as removable with the housing 200. In particular, the capsule, and therefore the sensor 2, preferably engages in a cavity 210 of the housing 200 located on its face intended to be in contact with the skin. The sensor 2 comprises an outer face 22 opposite the inner face 21.
[0086] The housing 200 and the capsule may have complementary shapes, which limits the effort required for proper insertion of the capsule against the housing 200.
[0087] The patch 40 has an adhesive layer, or is itself made of an adhesive material. The patch thus allows the capsule to attach to the wearer's skin and helps retain the needles 10 in the interstitial fluid. The patch 40, for example, has an annular shape and covers the capsule.
[0088] The sensor 2 shown here is circular with a central opening 23, but it can take other shapes: rectangular, oblong, ellipsoidal, with or without a central opening. The central opening 23 allows the sensor 2 to be correctly positioned in the cavity 210 of the housing, which includes a central positioning pin (not shown).
[0089] Sensor 2 therefore includes elements which allow the liquid to be collected or the signals detected by each microneedle to be brought to the housing 200 for processing (not described here).
[0090] The sensor 2 can take the form of a plastic plate, a printed circuit board (rigid or flexible silicon), a non-conductive metal plate such as aluminium.
[0091] The adhesive patch 40 is designed to adhere to the skin and supports the sensor 2, allowing the unit 200 to be detached without removing the sensor 2, keeping it attached to the body. This configuration avoids the need to remove the sensor 2 for certain operations that only involve the unit 200: battery charging, repair, replacement, and data transfer to a computer.
[0092] The housing 200 is advantageously in the shape of a watch case and includes means 230 for attaching the device to a user's wrist. These include a strap adapted to encircle a user's wrist. The strap is preferably adjustable.
[0093] The housing 200 contains several elements for analyzing or extracting interstitial fluid. In this regard, reference may be made to document WO 2019 / 141743 in the name of the applicant, which describes in detail the measurement and detection of a physical quantity using microneedles in contact with a bodily fluid that may or may not be sampled.
[0094] Advantageously, the watch further includes a wireless communication interface, for example via a 3G and / or 4G and / or telecommunications network 5G and / or Wi-Fi and / or Bluetooth and / or NFC and / or DECT.
[0095] Also, the watch may include a light indicator such as a diode, which can be used to signal the end of a sensor preparation operation.
[0096] The needles 10 are advantageously microneedles. The sensor 2 preferably comprises between four and fifty microneedles, or even four hundred microneedles. Of course, a different number can be considered without limiting the description of the invention given here.
[0097] A microneedle is defined as a needle with a small height, preferably between 10 µm and 1000 µm, and preferably between 0.3 mm and 0.8 mm. The height of the microneedles is sufficiently small to avoid contact with a nerve causing mechanical pain in the wearer when the device is worn. The length of the needles 10 is thus sufficiently reduced to avoid contact with a nerve of the user, thereby limiting the pain caused by wearing the device 100.
[0098] The microneedles 10 allow for the measurement of bodily fluid. The microneedles 10 are solid for direct analysis of the fluid. To analyze the fluid, the microneedles do not collect any fluid and instead incorporate the sensor on their surface in the form of a coating such as a biochemical material capable of reacting with the analysis to be performed on the fluid.
[0099] Each needle, for example, has a pyramidal shape.
[0100] Advantageously, the sensor 2 comprises several microneedles forming a network of microneedles in that they are electrically connected to each other in groups. The microneedles 10 pierce the skin to come into contact with the interstitial fluid when the sensor is in contact with the skin.
Claims
Demands
1. A method for measuring the concentration of at least one analyte by means of an analyte concentration (AC) monitoring device (1) comprising an analyte concentration measurement sensor (2) and a motion measurement module (3) of the monitoring device (1), the monitoring device (1) comprising a processing unit (4) connected to the sensor (2) and the motion measurement module (3), the monitoring device (1) being in the form of a watch case and comprising means for attaching the device to and in contact with a user's wrist (E0) of a user's wrist, the method comprising the following steps carried out by the processing unit (4): - calibration (E01) of the monitoring device (1) to determine a reference position that corresponds to a constrained positioning of the user's wrist in a particular position; - measurement (E1) of at least one analyte concentration (AC) by means of the sensor (2);- determination (E2) of a movement of the monitoring device (1) by means of the motion measurement module (3); - correction (E3) of the measurement of the analyte concentration (CA) as a function of the movement of the monitoring device (1) thus determined, the correction (E3) of the rotational movement (MR) of the monitoring device (1) being carried out for a rotational movement (MR) of 20° minimum, preferably between 90° and 180° measured from a reference position.;
2. Method according to claim 1, wherein the sensor (2) of the monitoring device (1) is a microneedle sensor (2) (10).
3. Method according to any one of claims 1 to 2, the motion measurement module (3) comprising a gyroscope (31), the determined motion being a rotational motion (MR) of the monitoring device (1) over time.
4. A method according to any one of claims 1 to 3, the motion measurement module (3) comprising an accelerometer (32), so as to determine (E2) an acceleration motion (MA) of the monitoring device (1) over time.
5. According to any one of claims 1 to 4, the motion measuring module (3) and the sensor (2) are configured to perform their respective concentration and motion measurements in a suc- cessive, the measurements including motion, analyte concentration (AC) time and space data.
6. A method according to any one of claims 1 to 5, wherein motion and analyte concentration (AC) measurements are carried out at different or equal frequencies, the motion measurement module and the sensor being synchronized on the same time base.
7. A method according to claim 6, wherein each measurement frequency is variable depending on the measurements of the movement and / or external parameters specific to the user.
8. Microneedle device comprising a processing unit (4) configured to carry out a method according to any one of claims 1 to 7.