NEW BONE REGENERATION SYSTEM

Abstract

The present invention relates to 1) a bone regeneration kit for a bone defect site in a patient's jawbone, comprising A) a bone regeneration substitute for filling the bone defect and B) a bone regeneration system incorporating a device for maintaining the bone regeneration substitute and, optionally, a covering membrane on said bone defect; 2) such a bone regeneration system; and 3) such a device for maintaining the bone regeneration substitute and, optionally, the covering membrane on said bone defect.

Description

Title of the invention: NEW BONE REGENERATION SYSTEM FIELD OF INVENTION

[0001] The present invention relates to the field of devices for bone regeneration and, more specifically, to that of the stabilization of endo-osseous dental implants. EARLIER ART

[0002] Classically, endosseous implants take the form of an anchor foot adapted for implantation in a patient's jawbone, which anchor foot most often corresponds to an anchor screw.

[0003] An example of such implants is given in US patent application 2003 / 232308, in which an anchor foot (base) intended to be positioned in a complementaryly shaped cavity prepared in the patient's jawbone also has a collar (platform) extending from the base, with which it thus forms a single piece. This anchor foot most often cooperates with an external abutment intended to be fixed within the anchor foot and which is coupled to a prosthetic connection for attaching a crown to replace the missing tooth.

[0004] Now, such an implantation can prove complicated by the presence of bone defects within the patient's jaw itself. Such bone defects, which can have multiple origins (infectious, tumoral, or traumatic), result from impaired bone healing and correspond to cavities in place of the destroyed bone.

[0005] Faced with such bone defects, it is possible to use biomaterials which allow both the filling of the bone defect and the promotion of bone healing within it.

[0006] Generally, the biomaterial used consists of either synthetic bone substitute material (e.g., hydroxyapatite granules) or bone particles. Once the cavity corresponding to the bone defect has been filled with this biomaterial, the cavity is closed by a membrane or a cover plate that directs and contains the growth of this biomaterial; this is called Guided Bone Regeneration (GBR). Examples of such membranes and cover plates include those described in US patent 4,816,339 and EP patent 2,536,446 B1, respectively.

[0007] Each of these solutions (membrane or cover plate) has its respective advantages and disadvantages.

[0008] The covering membrane, by its structure, allows the passage of nutrients that promote bone regeneration while remaining uncolonized by bone cells. Therefore, the covering membrane can be easily removed once regeneration is complete without risk of weakening or dislodging regenerated bone. However, the "flexible" nature of this covering membrane makes it difficult to contain the volume of bone regeneration.

[0009] Conversely, the overlay plate, due to its rigidity, optimally guides the volume of this regeneration. However, the perforation of its structure to allow the passage of nutrients to the regeneration site leads to its colonization by bone cells. Consequently, the removal of the overlay plate at the end of regeneration is complicated and may affect the integrity of the regenerated bone.

[0010] As for the retention of the membrane or cover plate, this is ensured by screws fixed to the bone surrounding the bone defect. Now, in the case of a moderately sized bone defect, it can also be ensured, in combination with the anchoring post of the future dental implant prepositioned within the bone defect of the patient's jaw, by a screw fixed to said anchoring post. The need for multiple fixation points significantly complicates the implementation of these solutions by the practitioner, in addition to increasing the trauma to the already weakened bone of the patient's jaw.

[0011] It is also important to develop new bone regeneration solutions, particularly for moderately sized bone defects, which offer simplified implementation for the patient, minimal trauma to the patient's jawbone, while ensuring the best possible result in terms of bone regeneration at the bone defect site. SUMMARY OF THE INVENTION

[0012] Faced with this problem, the inventor has now developed a new solution adapted to the bone regeneration of moderately sized bone defects which, apart from the fixation associated with the anchoring base of the future implant, requires no fixation in the bone surrounding the bone defect, while providing improved coverage of the bone regeneration volume. This particularly innovative solution may or may not use a covering membrane.

[0013] In detail, a first object of the invention relates to a bone regeneration kit for a bone defect site in a patient's jawbone, which comprises:

[0014] A) a bone regeneration substitute allowing the filling of the bone defect and

[0015] B) a bone regeneration system comprising:

[0016] 1) at least one anchor foot adapted for endo-osseous installation in the jawbone, preferably within the bone defect itself;

[0017] 2) possibly at least one cover membrane, preferably a covering membrane whose surface area allows at least the entire bone defect filled by the bone regeneration substitute to be covered;

[0018] 3) at least one device intended to ensure the maintenance of the regeneration substitute bone and, possibly, the covering membrane over said bone defect which includes:

[0019] 3a) on its face directed towards the bone, at least one external pillar intended to be fixed in the anchor foot, which external pillar includes anti-rotational means for inhibiting the relative movements of the external pillar with respect to the anchor foot once the external pillar is placed in the anchor foot; and

[0020] 3b) on its face opposite the bone, at least one cover piece placed on the bone regeneration substitute and, optionally, on the cover membrane so as to delimit, in combination with said bone regeneration substitute and, optionally, said cover membrane, the volume of bone regeneration at said bone defect site, which cover piece has:

[0021] 3bi) a central part, extending from the external pillar, and

[0022] 3bii) at least 2 long-line lateral extensions (7a, 7b) in the continuation of this i) central part whose axis intersects perpendicularly the central axis (AA), corresponding to the axis crossing the central part and the 1) at least one anchoring pillar, preferably each long-line lateral extension (7a, 7b) does not include any orifice intended for the positioning of a fixing screw and / or said long-line lateral extensions (7a, 7b) are flexible.

[0023] A second object of the invention relates to a bone regeneration system as described above.

[0024] A third object of the invention relates to a device for maintaining the bone regeneration substitute and, optionally, the covering membrane as defined above.

[0025] According to a preferred embodiment, the device for ensuring the retention of the bone regeneration substitute and, optionally, the cover membrane on the bone defect comprises 3c) an intermediate pillar, between 3a) the external pillar and 3b) the cover piece.

[0026] According to another preferred embodiment, the system according to the invention further comprises:

[0027] - and for 3) at least one device ensuring the retention of the substitute bone regeneration and, possibly, of the covering membrane, 3d) at least one screw which has, at its distal end, an external thread, and provided within 3a) at least one external pillar and, if present, within 3c) at least one intermediate pillar, an internal cavity allowing the passage of said 3d) at least one screw but not its head; and

[0028] - within 1) at least one anchor foot, a cavity in which is provided a tapping which can cooperate with the thread of the d) at least one screw to allow the assembly of said 1) at least one anchor foot and 3) at least one device ensuring the retention of the bone regeneration substitute and, possibly, of the cover membrane by screwing the thread of the 3d) at least one screw into the tapping of the internal cavity of the 1) at least one anchor foot.

[0029] According to yet another preferred embodiment, 3a) the cover piece forms a single piece with 3b) the external pillar and, optionally, 3c) the intermediate pillar.

[0030] According to a complementary preferred embodiment, the system according to the invention further comprises 4) at least one part which is complementary to 3) at least one device intended to ensure the retention of the covering membrane on a bone defect, which 3) at least one complementary part makes it easier for the practitioner to grasp it when putting it in place.

[0031] A fourth object relates to a bone regeneration method for a bone defect site in a patient's jawbone, which method comprises the steps of:

[0032] 1) placement of an anchor foot within the patient's jawbone at the level or at proximity to the bone defect;

[0033] 2) filling of the bone defect with a bone regeneration substitute;

[0034] 3) possibly positioning, on this bone regeneration substitute, of a cover membrane;

[0035] 4) placement, preferably on this cover membrane, of a device intended to the maintenance of the bone regeneration substitute and, possibly, the covering membrane as defined previously. DESCRIPTION OF THE FIGURES

[0036] Fig. 1 is a cross-sectional view of the implantation in the jawbone of a patient of an embodiment of the bone regeneration system according to the invention.

[0037] Fig. 2 is a cross-sectional view of this same embodiment of the bone regeneration system according to the invention.

[0038] Fig. 3, Fig. 4, Fig. 5 and Fig. 6 show schematic views under different angles of an embodiment of a device intended for maintaining the bone regeneration substitute according to the invention. DETAILED DESCRIPTION OF THE INVENTION

[0039] Bone regeneration substitutes are well known to those skilled in the art, and such a substitute can be chosen from among those used for filling bone defects in various pathologies. Such a bone regeneration substitute can consist of a synthetic bone substitute material (e.g., hydroxyapatite granules), but also of bone particles. Examples of bone regeneration substitutes include RE-BONE, BIO-OSS, BIOSORB-DENTAL, CREOS, ADBONE, TEEBONE, SYBONE, etc.

[0040] As for the anchor feet, these are also well known to practitioners and typically take the form of a screw that can be screwed into a prepared and shaped recess in the patient's jawbone. The patient's jawbone is thus tapped to obtain a thread that will then allow the anchor foot to be fixed. The screw of the anchor foot may be cylindrical or conical in shape.

[0041] The material of this anchor foot is advantageously compatible with the biological material of the bone so as to facilitate its osseointegration in the jaw (maxillary and mandibular bones). Typically, this anchor foot can be made of zirconia (ceramic), titanium, or a titanium alloy.

[0042] In terms of dimensions, such an anchor foot has:

[0043] - a length between 0.2 and 1.5 cm, preferably between 0.5 and 0.8 cm; and

[0044] - a section between 3 and 8 mm, preferably between 3 and 6 mm.

[0045] Covering membranes have long been used in Guided Bone Regeneration (GBR) and are, in fact, well known to practitioners. They can be resorbable or non-resorbable.

[0046] The cover membranes used conventionally are non-resorbable and are made from ePTFE (Expanded Polytetrafluoroethylene) with the possibility of mechanical reinforcement with a metallic frame; typically in titanium (ePTFE TR for Titanium Reinforced).

[0047] Absorbable membranes, on the other hand, can be either synthetic or collagenous.

[0048] Synthetic membranes are typically made of polylactic acid and polyglycolic acid copolymers, which is why they are absorbed by hydrolysis. Examples of such synthetic membranes include the following: marketed under the names ATRISORB, VICRYL, RESOLUT TM / RESOLUT XT.

[0049] Collagen membranes were first used in 1996 and are made from cross-linked or non-cross-linked collagen of bovine or porcine origin with cross-linked or non-cross-linked fibers. Examples of such collagen membranes include those marketed under the names AVITENE, PAROGUIDE, BIO-GUIDE, PERIOGEN, and BIOMEND.

[0050] The dimensions of at least one covering membrane are such that it should, preferably, allow at least the entire bone defect to be covered.

[0051] Typically, such a cover membrane has:

[0052] - a length between 0.5 and 2.5 cm, preferably between 0.5 and 1.5 cm; and

[0053] - a width between 0.5 and 2.5 cm, preferably between 0.5 and 1.5 cm.

[0054] The device intended to ensure the maintenance of the bone regeneration substitute and, The covering membrane over the bone defect must, if necessary, have sufficient rigidity to ensure its function. Preferably, the covering piece of this device should also have sufficient elasticity to allow for adjustment during placement by bending its long, lateral extensions, so as to define, possibly in combination with the covering membrane, the volume of bone defect regeneration.

[0055] To achieve this, the device ensuring the retention of the bone regeneration substitute and, possibly, of the cover membrane or, at a minimum, its cover piece, is advantageously made of titanium.

[0056] Titanium is a bright transition metal with low density and high strength. Pure titanium is therefore stronger than ordinary low-carbon steels, while being 45% lighter. The integration of titanium into various alloys allows them to possess particularly interesting properties. Thus, titanium alloys are generally used for most applications with small amounts of aluminum and vanadium, typically 6% and 4% by weight, respectively. Titanium can exist in two crystalline forms (alpha and beta), and titanium alloys, depending on their composition, will orient the titanium towards one or the other of these crystalline forms, thereby modifying the properties of the alloy.Among these alloys, Grade 1 titanium, or T35, and Grade 2 titanium, or T40, constitute specific alloys, whose composition (in Titanium, Oxygen, Iron, Carbon, Hydrogen and Nitrogen) and characteristics are well known to those skilled in the art.

[0057] Advantageously, the device ensuring the retention of the bone regeneration substitute and, optionally, of the cover membrane is made of grade 1 or grade 2 titanium.

[0058] According to a preferred embodiment, 3) at least one device for ensuring the maintenance of the A) bone regeneration substitute and, optionally, of the 2) at least one cover membrane on the bone defect comprises, between 3a) at least one external pillar and 3b) at least one cover piece, 3c) at least one intermediate pillar which could be described as a transmucosal part.

[0059] Ideally, the height of this 3c) at least one intermediate pillar is within the range of 0.5 to 5 mm, preferably within the range of 1 to 2 mm.

[0060] Preferably, this 3c) at least one intermediate pillar includes a constriction in the width direction extending towards the jawbone and may optionally also include a scalloped edge. This constriction ideally has a conical profile, which conical profile is free of any potentially sharp angles.

[0061] According to another preferred embodiment, the system according to the invention further comprises:

[0062] - and for 3) at least one device ensuring the retention of the substitute bone regeneration and, possibly, of the covering membrane, 3d) at least one screw which has, at its distal end, an external thread, and provided within a) at least one external pillar and, if present, within 3c) at least one intermediate pillar, an internal cavity allowing the passage of said 3d) at least one screw but not its head; and

[0063] - within 1) at least one anchor foot, a cavity in which is provided a tapping which can cooperate with the thread of the 3d) at least one screw to allow the assembly of said 1) at least one anchor foot and 3) at least one device ensuring the retention of the bone regeneration substitute and, possibly, of the cover membrane by screwing the thread of the 3d) at least one screw into the tapping of the internal cavity of the 1) at least one anchor foot.

[0064] In this embodiment, this 3d) at least one screw allows the assembly by trans-screwing of said 1) at least one anchor foot and 3) at least one device ensuring the retention of the bone regeneration substitute and, possibly, of the cover membrane.

[0065] Advantageously, the head of said 3d) at least one screw and 3a) at least one external pillar or, if present, 3c) at least one intermediate pillar have centering means. Typically, these centering means are such that the head of said d) at least one screw and 3a) at least one external pillar or, if present, 3c) at least one intermediate pillar comprise complementary female and male portions. Preferably, these complementary female and male forms are frustoconical forms with a vertical axis. Therefore, in addition to centering, these forms make it possible to inhibit relative movements and ensure a seal between d) at least one screw and the a) at least one external pillar or, if present, the c) at least one intermediate pillar.

[0066] Preferably, d) at least one screw and a) at least one external pillar or, if present, 3c) at least one intermediate pillar have complementary centering means which are included in the length of 3d) at least one screw and in the internal cavity of 3a) at least one external pillar or, if present, of 3c) at least one intermediate pillar.

[0067] Advantageously, a thread is provided within the internal cavity of (a) at least one external abutment. This thread can cooperate with an external thread present, for example on an extractor, so as to allow the disassembly of (1) at least one anchor foot of (3) at least one device intended to ensure the retention of the bone regeneration substitute and, optionally, the covering membrane on said bone defect.

[0068] Now in relation to 3b) at least one cover piece, this has 3bi) a central part, in line with 3a) at least one external pillar or, if present, 3c) at least one intermediate pillar, which 3bi) central part is advantageously circular and then typically takes the form of a washer.

[0069] This 3b) at least one cover piece further has, 3bii) at least 2 long lateral extensions, preferably 3bii) at least 3 extensions, which long lateral extensions are advantageously flexible.

[0070] Also, the 3bi) central part of the 3b) at least one cover piece constitutes the base of the 3bii) at least 2 longline lateral extensions, preferably of the 3bii) at least 3 longline lateral extensions.

[0071] The long, slender lateral extensions have sufficient length and width to allow their positioning on the bone regeneration substitute and, optionally, the covering membrane, and to ensure their retention. Typically, the long, slender lateral extensions have a length of between 3 and 15 mm, preferably between 3 and 10 mm. Also typically, the long, slender lateral extensions have a width of between 1 and 8 mm, preferably between 2 and 5 mm.

[0072] Advantageously, and to facilitate the adaptation of the device designed to maintain the bone regeneration substitute and, optionally, the covering membrane, to each patient, each long lateral extension may have one or more predetermined breaking points positioned along its length. In this way, when the device is placed by the practitioner, the practitioner will be able to use one or more of these predetermined breaking points to shorten all or part of these long lateral extensions and adapt them to the patient's morphology. Following this shortening, the practitioner will be able to simply, using the using the instruments at his disposal, eliminate the angles of the point(s) of rupture used, so as not to risk injuring the patient.

[0073] Advantageously, and again to facilitate the adaptation of the device designed to maintain the bone regeneration substitute and, if necessary, the covering membrane, to each patient, each long, lateral extension may have one or more initiators positioned along its length that facilitate its folding. In this way, when the device is applied by the practitioner, one or more of these initiators will be able to use them to fold all or part of these long, lateral extensions and adapt them to the patient's anatomy.

[0074] The 3bi) central part of the 3b) at least one cover piece has two distinct halves corresponding to a vestibular half and a palatine half corresponding to the half turned towards the vestibular side (i.e. towards the outside of the mouth) and the half turned towards the palatine side (i.e. towards the palate) respectively.

[0075] Advantageously, the long lateral extensions in the continuation of the vestibular half of the central part, or vestibular long lateral extensions, have a greater length than the long lateral extensions in the continuation of the palatine half of the central part, or palatine long lateral extensions.

[0076] This feature makes it easier for the practitioner to differentiate between the vestibular side and the palatal side of the device intended to maintain the bone regeneration substitute and, possibly, the covering membrane.

[0077] Typically, the vestibular longline lateral extensions have a length between 4 and 10 mm.

[0078] Advantageously, there will be 2 to 5 vestibular longline lateral extensions, preferably 3 to 4 and, particularly preferably, 3 vestibular longline lateral extensions.

[0079] Ideally, the vestibular lateral extensions have the same spacing between them. Typically, said spacing is at least 10°, preferably at least 20° and, particularly preferably, at least 25°.

[0080] As for the long lateral palatine extensions, their length is typically between 3 and 6 mm.

[0081] Advantageously, there will be 1 to 4 long palatine lateral extensions, preferably 2 to 3 and, particularly preferred, 2 long palatine lateral extensions.

[0082] Ideally, the long lateral palatine extensions should always have the same spacing between them. Typically, this spacing is at least 10°, preferably at least 20°, and particularly preferably at least 25°.

[0083] To showcase its particularly advantageous properties:

[0084] - 3bi) at least a central part of 3b) at least one cover piece of 3) at least one device according to the invention has a thickness between 0.3 and 3 mm, preferably between 0.5 and 1.5 mm.

[0085] - the long, slender lateral extensions have a thickness between 0.1 and 1.5mm, preferably between 0.3 and 1 mm.

[0086] According to another preferred embodiment, 3b) at least one cover piece forms a single piece with 3a) at least one external pillar and, optionally, 3c) at least one intermediate pillar. To achieve this, these can be made simultaneously as a single piece or joined subsequently, in particular by welding or crimping.

[0087] Suitable methods for manufacturing 3b) at least one cover piece with 3a) at least one external pillar and / or with 3c) at least one intermediate pillar in a single piece are well known to those skilled in the art. Examples of such methods include molding, milling, and 3D printing. In the case of 3D printing, this typically uses a metal powder shaped by a laser of appropriate power.

[0088] Similarly, welding or crimping can be carried out using techniques well known to those skilled in the art. In the case where 3) at least one device is made of titanium or a titanium alloy, the welding of its various components can then be carried out, in particular, by laser, friction, or electron beam welding.

[0089] In connection with 4) at least one additional part of the device ensuring the retention of the covering membrane (6) and which makes it easier for the practitioner to grasp said device, this 4) at least one additional part therefore makes it easier for the practitioner to position said 3) at least one device on the 1) at least one anchoring pillar in the patient's mouth.

[0090] Typically, this additional piece which constitutes a means of gripping takes the form of a sleeve, which may be made of plastic, and which clips onto the central part of the 3) at least one cover piece (8), typically in a housing provided within this central part.

[0091] The following examples are provided for illustrative purposes only and shall not limit the scope of the present invention.

[0092] Bone regeneration of a bone defect in the jaw for the purpose of placing dental implants

[0093] In the context of a bone defect within the jaw, it is necessary to allow regeneration of this bone defect before dental implants can be considered.

[0094] To achieve this, an incision is made in the gum to access this bone defect in the jaw. This incision is made by raising the gum flap resulting from the incision.

[0095] The practitioner can then drill into the jawbone, ideally at or near the bone defect. The practitioner then inserts an anchor foot into the previously drilled hole.

[0096] Once this placement has been carried out, the practitioner fills the bone defect with a bone regeneration substitute.

[0097] Fig. 1 shows a cross-sectional view of the incised gingiva, allowing access to the bone defect with elevation of a gingival flap (L) following the incision. The anchor foot (3) positioned within the borehole drilled by the practitioner in the patient's jawbone (1) is also visible. Around the anchor foot (3), the bone defect is filled with the bone regeneration substitute (11). The anchor foot (3) is surmounted by the device (2) for retaining the bone regeneration substrate (11), to which it is attached by a screw (9). Note that, in this section, the covering membrane (6) is positioned on the device (2).

[0098] Figure 2 shows a cross-sectional view of the bone regeneration system presented in Figure 1, in which the anchor foot (3) and the device (2) with its elongated lateral extensions (7a, 7b) are observed. This anchor foot (3) and this device (2) are joined by screwing the external thread (9a) of a screw (9) into the threaded hole (3b) of the internal cavity (3a) of the anchor foot (3). Indeed, an internal cavity (4a) of the device (2) for retaining the bone regeneration substitute (11) allows the passage of this screw (9) but not its head (9b).

[0099] Figures 3 to 6 show schematic views from different angles of a device (2) for retaining the bone regeneration substitute. In these figures, the device (2) can be seen with its external abutment (4), which external abutment (4) is equipped with anti-rotational means in the form of a Morse taper to limit the movement of the device (2) once its external abutment (4) is positioned within the complementary cavity of the anchoring foot (see [Fig. 2]). This external abutment (4) is surmounted by an intermediate abutment (5) of conical shape to facilitate its passage through the gingiva. Above the intermediate abutment (5) is positioned the cover piece (8) with its cylindrical central portion (12), which central portion (12) is an extension of the intermediate abutment (5).The long lateral extensions (7a, 7b) of the cover piece (8) include two palatine long lateral extensions (7b), the shortest, and three extensions. The longest vestibular lateral extensions (7a) are also included. These vestibular lateral extensions (7a) each have a break point (10) to facilitate adjustment of the device (2) by the practitioner, ensuring a secure and comfortable fit for the patient. These same vestibular lateral extensions (7a) also include two locating points (13) positioned along their length to facilitate folding by the practitioner and adjustment of the device to the patient's anatomy.

[0100] Figure 4 shows an aerial view of the cover piece (8) of the device (2), which allows for a better understanding of the specific arrangement of its components. In this view, the long, slender lateral extensions (7a, 7b) can be seen, extending from the central portion (12), whose axis intersects the central axis (AA) perpendicularly (also visible in Figure 6). Also visible in this view are the internal cavity (4a) passing through the cover piece (8), as well as (not visible in this view) the external pillar and the intermediate pillar.

Claims

1. Demands System for bone regeneration at a bone defect site in a patient's jawbone (1) with a bone regeneration substitute (11) enabling the filling of said bone defect, comprising: 1) at least one anchor foot (3) adapted for endo-osseous installation in the jawbone (1), preferably within the bone defect itself; 2) optionally, at least one cover membrane (6), preferably a cover membrane (6) whose surface area allows at least the entire bone defect to be covered; 3) at least one device (2) intended to ensure the retention of a bone regeneration substitute and, optionally, a covering membrane (6) on a patient's bone defect, which comprises: 3a) on its face directed towards the bone (1), at least one external pillar (4) intended to be fixed in an anchor foot (3), which external pillar (4) includes anti-rotational means for inhibiting the relative movements of the external pillar (4) with respect to the anchor foot (3) once the external pillar (4) is placed in the anchor foot (3); and 3b) on its face opposite the bone (1), at least one cover piece (8) placed on the bone regeneration substitute (11) and, optionally, the cover membrane (6) so as to delimit, in combination with said bone regeneration substitute (11) and, optionally, said cover membrane (6), a bone regeneration volume at said bone defect site, which a) cover piece (8) forms a single piece with b) the external pillar (4) and has: 3bi) a central part (12), extending from the external pillar (4), and 3bii) at least 3 flexible, long, slender lateral extensions (7a, 7b) extending from this i) central part (12), the axis of these at least three long, slender lateral extensions intersecting perpendicularly the central axis (AA) passing through the central part (12) and the 1) at least one anchoring pillar (3), each extension lateral longline (7 a, 7b) not including any orifice intended for the positioning of a fixing screw, the system further includes 4) at least one part which is complementary to 3) at least one device (2), which 4) at least one complementary part makes it easier for the practitioner to grasp said device and takes the form of a sleeve which may be made of plastic and which clips onto the central part of 3) at least one cover piece (8) in a housing provided within this central part.

2. The system according to claim 1, characterized in that it comprises 2) at least one cover membrane (6), preferably said at least one cover membrane (6) is of a resorbable or non-resorbable nature

3. The system according to any one of claims 1 or 2 characterized in that it further comprises: - and for 3) at least one device (2) intended to ensure the retention of the bone regeneration substitute (11) and, optionally, of the cover membrane (6), 3d) at least one screw (9) which has, at its distal end, an external thread (9a), and provided within a) at least one external pillar (4) and, if present, within 3c) at least one intermediate pillar (5), an internal cavity (4a) allowing the passage of said 3d) at least one screw (9) but not of its head (9b);and - within the 1) at least one anchor foot (3), a cavity (3a) in which is provided a thread (3b) which can cooperate with the thread (9a) of the d) at least one screw (9) to allow the assembly of said 1) at least one anchor foot (3) and 3) at least one device (2) ensuring the retention of the bone regeneration substitute (11) and, possibly, of the cover membrane (6) by screwing the thread (9a) of the 3d) at least one screw (9) into the thread (3b) of the internal cavity (3a) of the 1) at least one anchor foot (3).;

4. The system according to any one of claims 1 to 3, characterized in that the central part of the covering piece (3b) (3b) has two distinct halves corresponding to a vestibular half facing vestibularly and a palatal half facing palatally, and in that the elongated lateral extensions in the continuation of the half vestibular of the central part (7a), or vestibular longline lateral extensions, have a greater length than the longline lateral extensions in the continuation of the palatine half of the central part (7b) or palatine longline lateral extensions.

5. The system according to any one of the preceding claims, characterized in that each longline lateral extension (7a, 7b) has one or more predetermined breaking points (10) positioned in its length.

6. The system according to any one of the preceding claims, characterized in that it comprises 3c) an intermediate pillar (5), between 3a) the outer pillar (4) and 3b) the cover piece (8).

7. A bone regeneration kit for a bone defect site in a patient's jawbone (1) comprising: A) a bone regeneration substitute (11) enabling the filling of the bone defect and B) a bone regeneration system as defined in any one of claims 1 to 6.

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