Composition includes plant extracts.

Abstract

The invention relates to a composition comprising plant extracts, in particular extracts of Fagus, Abies, Rubus, Corylus, Crataegus, Rosa, and Fraxinus. The invention also relates to the use of the composition according to the invention as a medicinal product, in particular for the prevention and treatment of respiratory, ENT, or rheumatic diseases.

Description

Title of the invention: Composition comprising plant extracts. Technical field of the invention

[0001] The present invention relates to a composition comprising plant extracts, and intended to be used as a medicinal product. Description of the invention

[0002] A first object of the invention relates to a composition comprising at least six plant extracts chosen from among an extract of Fagus; an extract of Abies; an extract of Rubus; an extract of Corylus; an extract of Crataegus; an extract of Rosa; an extract of Fraxinus; and an extract of Carpinus.

[0003] In one embodiment, the composition according to the invention comprises at least one extract of Fagus; one extract of Abies; one extract of Rubus; one extract of Corylus; one extract of Crataegus; one extract of Rosa; and one extract of Fraxinus.

[0004] For example, the composition according to the invention comprises an extract of Fagus in a mass proportion of between 37% and 43%; an extract of Abies in a mass proportion of between 21% and 27%; an extract of Rubus in a mass proportion of between 12% and 18%; an extract of Corylus in a mass proportion of between 6% and 12%; an extract of Crataegus in a mass proportion of between 3% and 9%; an extract of Rosa in a mass proportion of between 0.5% and 6%; and an extract of Fraxinus in a mass proportion of between 0.5% and 6%.

[0005] In an alternative embodiment, the composition according to the invention comprises at least one extract of Fagus; one extract of Abies; one extract of Rubus; one extract of Carpinus; one extract of Crataegus; one extract of Rosa; and one extract of Fraxinus.

[0006] For example, the composition according to the invention comprises an extract of Fagus in a mass proportion of between 37% and 43%; an extract of Abies in a mass proportion of between 21% and 27%; an extract of Rubus in a mass proportion of between 12% and 18%; an extract of Carpinus in a mass proportion of between 6% and 12%; an extract of Crataegus in a mass proportion of between 3% and 9%; an extract of Rosa in a mass proportion of between 0.5% and 6%; and an extract of Fraxinus in a mass proportion of between 0.5% and 6%.

[0007] In one embodiment, the composition according to the invention may further comprise one or more extracts selected from: an extract of Alnus, preferably an extract of the species Alnus glutinosa; an extract of Tilia, preferably an extract of the species Tilia tomentosa; an extract of Quercus, preferably an extract of the species Quercus robur; an extract of Juniperus, preferably an extract of the species Juniperus communis; an extract of Acer, preferably an extract of the species Aces campestris; an extract of Cornus, preferably an extract of Cornus sanguinea.

[0008] In one embodiment, the extracts included in the composition according to the invention are liquid extracts, for example hydroglycerinated liquid extracts, hydroalcoholic liquid extracts, for example honeyed hydroalcoholic extracts, glycerinated hydroalcoholic extracts or oily macerates.

[0009] Preferably, the liquid extracts included in the composition according to the invention are honey-based hydroalcoholic liquid extracts. For the purposes of this invention, honey-based hydroalcoholic liquid extracts are defined as a plant extract prepared in a solvent comprising water, alcohol, and honey.

[0010] In one embodiment, the extracts included in the composition according to the invention are extracts obtained from buds, young shoots and / or rootlets of plants.

[0011] In one embodiment, the composition according to the invention is in liquid form.

[0012] Also proposed, according to a second object of the invention, is a composition according to the invention for its use as a medicinal product.

[0013] In one embodiment, the composition according to the invention can be used in the treatment or prevention of asthma, bronchitis, tracheitis, pulmonary emphysema, angina, rhinitis, osteoarthritis, osteoporosis, hypercholesterolemia, hyperuricemia, hyperglycemia, arteriosclerosis or hypertension.

[0014] In one embodiment, the composition for its use according to the invention can be administered to an immunocompromised patient.

[0015] Surprisingly, such a composition combining such extracts is particularly effective as a medicine, especially in the treatment or prevention of certain cardiopulmonary, inflammatory, metabolic, and osteoarticular pathologies, for example in patients also suffering from immunosuppression.

[0016] Other features and advantages of the invention will be better understood from reading the detailed description that follows. Detailed description Composition according to the invention.

[0017] A first object of the invention relates to a composition comprising at least six plant extracts chosen from an extract of Fagus; an extract of Abies; an extract of Rubus; an extract of Corylus; an extract of Crataegus; an extract of Rosa; an extract of Fraxinus, and an extract of Carpinus.

[0018] The composition according to the invention may include an extract of Fagus. The genus Fagus, or beech trees, belongs to the Fagaceae family and comprises deciduous trees.

[0019] In one embodiment, the Fagus extract in the composition according to the invention is obtained from buds, rootlets and / or seeds.

[0020] Fagus buds are known in particular for their anti-inflammatory and cholesterol-lowering properties. Fagus rootlets are known in particular for their anticonvulsant properties. Fagus seeds are known in particular for their role in preventing kidney stones.

[0021] The Fagus extract in the composition according to the invention may be an extract of the species Fagus sylvatica.

[0022] Such extracts of Fagus include, in particular, triterpenes derived from lupane and olealane, flavonoids derived from flavanones and flavonols, derivatives of glycosylated phenylpropanoids, as well as alkaloids derived from piperidine.

[0023] In one embodiment, the composition according to the invention comprises an extract of Fagus in a mass proportion of between 37% and 43% relative to the total mass of the composition.

[0024] The composition according to the invention may include an extract of Abies. The genus Abies belongs to the Pinaceae family and comprises coniferous trees.

[0025] In one embodiment, the Abies extract in the composition according to the invention is obtained from buds.

[0026] Abies buds are known in particular to promote erythropoiesis and osteogenesis.

[0027] The Abies extract in the composition according to the invention can be extracted from a species chosen from Abies alba Mill., Abies balsamea (L.) Mill., and Abies sibirica.

[0028] Such extracts of Abies include in particular diterpenes derived from abietan, lignans, flavonoids derived from flavones, steroids derived from lanosterol, monoterpenes such as pinene, fenchene, phellandrene, camphene, limonene or myrcene.

[0029] In one embodiment, the Abies extract in the composition according to the invention may be an extract of the species Abies alba.

[0030] In one embodiment, the composition according to the invention comprises an extract of Abies in a mass proportion of between 21% and 27% relative to the total mass of the composition.

[0031] The composition according to the invention may include an extract of Rubus. The genus Rubus, or brambles, belongs to the Rosaceae family and includes, in particular, woody plants.

[0032] In one embodiment, the Rubus extract in the composition according to the invention is obtained from young shoots.

[0033] The young shoots of Rubus are known for their antifibrotic properties, particularly on the renal, respiratory and vascular systems, as well as for their remineralizing action.

[0034] The Rubus extract in the composition according to the invention can be extracted from a species chosen from Rubus fructicosus L., Rubus caesius L., Rubus chingii var. suavissimus, and Rubus rosa.

[0035] Such Rubus extracts include, in particular, triterpenes derived from ursane and olealane, diterpenes derived from kaurane and labdane, sesquiterpenes derived from germacrane, gallic and allagic tannins, hydroxycinnamic derivatives, anthocyanins, and flavonoids derived from flavonols.

[0036] In one embodiment, the Rubus extract in the composition according to the invention may be an extract of the species Rubus fructicosus L.

[0037] In one embodiment, the composition according to the invention comprises an extract of Rubus in a mass proportion of between 12% and 18% relative to the total mass of the composition.

[0038] The composition according to the invention may include an extract of Corylus. The genus Corylus, or Hazelnut trees, belongs to the Betulaceae family and includes, in particular, forest shrubs.

[0039] In one embodiment, the Corylus extract in the composition according to the invention is obtained from buds.

[0040] Corylus buds are known in particular for their anti-anemic action.

[0041] The Corylus extract in the composition according to the invention may be an extract of the species Corylus avellana.

[0042] Such extracts of Corylus include, in particular, gallic and ellagic tannins, lignans, flavonoids derived from flavonols, as well as spermidine derivatives.

[0043] In one embodiment, the composition according to the invention comprises an extract of Corylus in a mass proportion of between 6% and 12% relative to the total mass of the composition.

[0044] In one particular embodiment, the Corylus extract in a composition according to the invention can be replaced by a Carpinus extract, for example an extract of the species Carpinus betulus.

[0045] For example, the extract of Carpinus may be present in the composition according to the invention in a mass proportion of between 6% and 12% relative to the total mass of the composition.

[0046] The composition according to the invention may include an extract of Crataegus. The genus Crataegus, commonly called Hawthorn, belongs to the Rosaceae family and includes, in particular, thorny shrubs.

[0047] In one embodiment, the Crataegus extract in the composition according to the invention is obtained from buds and / or young shoots.

[0048] Crataegus buds and young shoots are known in particular for their antioxidant and cytoprotective effect. The Crataegus extract in the composition according to the invention can be extracted from a species chosen from Crataegus oxyacantha, Crataegus curvisepala, Crataegus laevigata, Crataegus monogyna, Crataegus nigra, and Crataegus pentagyna.

[0050] Such extracts of Crataegus include, in particular, flavonoids derived from flavonols, gallic and ellagic tannins, as well as lignans.

[0051] In one embodiment, the Crataegus extract in the composition according to the invention may be an extract of the species Crataegus oxyacantha.

[0052] In one embodiment, the composition according to the invention comprises an extract of Crataegus in a mass proportion of between 3% and 9% relative to the total mass of the composition.

[0053] The composition according to the invention may include an extract of Rosa. The genus Rosa, corresponding to the genus of Roses or Dog Roses, belongs to the Rosaceae family and includes, in particular, thorny and climbing shrubs.

[0054] In one embodiment, the Rosa extract in the composition according to the invention is obtained from young shoots.

[0055] Rosa young shoots are particularly known for their antioxidant and cytoprotective effect.

[0056] The Rosa extract in the composition according to the invention can be extracted from a species chosen from Rosa canina, Rosa moschata Mill., and Rosa rubiginosa L..

[0057] Such Rosa extracts include, in particular, triterpenes derived from ursane, gallic and ellagic tannins, flavonoids derived from flavones and flavonols, carotenoids, vitamin C, anthocyanins, and unsaturated fatty acids.

[0058] In one embodiment, the Rosa extract in the composition according to the invention may be an extract of the species Rosa canina.

[0059] In one embodiment, the composition according to the invention comprises an extract of Rosa in a mass proportion of between 0.5% and 6% relative to the total mass of the composition.

[0060] The composition according to the invention may include an extract of Fraxinus. The genus Fraxinus, corresponding to the genus of Ash trees, belongs to the Oleaceae family.

[0061] In one embodiment, the Fraxinus extract in the composition according to the invention is obtained from buds.

[0062] Fraxinus buds are known in particular for their anti-inflammatory action.

[0063] The Fraxinus extract in the composition according to the invention may be an extract of the species Fraxinus excelsior.

[0064] Such extracts of Fraxinus include in particular diterpenes derived from abietan, lignans, gallic and ellagic tannins, as well as iridoids derived from oleuropein.

[0065] In one embodiment, the composition according to the invention comprises an extract of Fraxinus in a mass proportion of between 0.5% and 6% relative to the total mass of the composition.

[0066] In one embodiment, the composition according to the invention may further comprise one or more additional plant extracts, for example one or more extracts of buds, young shoots, or rootlets, chosen from: an extract of Alnus, preferably an extract of Alnus glutinosa; an extract of Tilia, preferably an extract of the species Tilia tomentosa; an extract of Quercus, preferably an extract of the species Quercus robur; an extract of Juniperus, preferably an extract of the species Juniperus communis; an extract of Acer, preferably an extract of the species Aces campestris; an extract of Cornus, preferably an extract of Cornus sanguinea.

[0067] By "buds" in the sense of the invention, we mean a set of very young leaf parts grouped on a short axis, rich in meristematic cells, which are capable of giving rise to new branches, leaves, flowers or fruits.

[0068] For the purposes of this invention, "young shoots" means new parts of a plant, for example a new leaf or a new branch, which have just begun to grow.

[0069] By "rootlets" in the sense of the invention, we mean fine roots which develop from a main root or a secondary root, and which constitute the terminal part of the root system.

[0070] Extracts usable in a composition according to the invention can be obtained by any method known to a person skilled in the art, for example by maceration or distillation.

[0071] According to a preferred embodiment, the extracts usable in a composition according to the invention can be obtained by cold maceration.

[0072] The extracts usable in a composition according to the invention may be liquid extracts, for example aqueous, hydroalcoholic, hydroglycerinated or hydro-alcoholic-glycerinated extracts.

[0073] In a preferred embodiment, the liquid extracts included in the composition according to the invention are obtained by macerating fresh, whole buds, rootlets, and / or young shoots in a ternary solvent comprising water, alcohol, and honey. The presence of honey in the extraction solvent allows for the preservation of the active ingredients in the composition.

[0074] For example, such a ternary solvent may comprise by volume a volume of water (approximately 33%), a volume of alcohol (approximately 33%) and a volume of honey (approximately 33%).

[0075] For example, buds, rootlets and / or young shoots can macerate in the ternary solvent for a period of 21 to 35 days.

[0076] For example, liquid extracts can be obtained by macerating 100 g of buds, rootlets and / or young shoots in 1 kg of ternary solvent.

[0077] The composition according to the invention may be in liquid form, and for example be formulated in bottles or ampoules. Use of the composition.

[0078] A second object of the invention relates to a composition as defined above, for its use as a medicinal product.

[0079] In one embodiment, the composition according to the invention can be used as a food supplement.

[0080] In one embodiment, the composition according to the invention can be used in the treatment or prevention of hypercholesterolemia, hyperuricemia or hyperglycemia.

[0081] The composition according to the invention is particularly suitable for the preventive or curative treatment of winter-type pathologies, which can be caused by cold and / or humidity, for example pathologies of the ENT, pulmonary sphere.

[0082] In one embodiment, the composition according to the invention can be used in the treatment or prevention of infectious or non-infectious pathologies of the ENT and / or pulmonary sphere, such as angina, rhinitis, bronchitis, tracheitis, asthma, or pulmonary emphysema.

[0083] In one embodiment, the composition according to the invention can be used in the treatment or prevention of rheumatism, osteoarthritis or osteoporosis.

[0084] In one embodiment, the composition according to the invention can be used in the treatment or prevention of hypertension or arteriosclerosis.

[0085] In one embodiment, the composition according to the invention can be used for the treatment of the pathologies defined in this description in an immunocompromised patient.

[0086] For the purposes of this invention, "immunocompromised" means a patient with an immune dysfunction, in particular a decrease in the number of leukocytes, for example caused by a pathology, such as lymphoma, or caused by a therapeutic treatment having an immunosuppressive action, such as chemotherapy.

[0087] In one embodiment, the composition can be administered to a patient orally.

[0088] In one embodiment, the composition can be administered to a patient in an amount of 0.75 ml to 3.5 ml per dose, at a frequency of one, two, or three doses per day.

[0089] For example, the composition can be administered to a patient for the prevention of the pathologies mentioned in this description in an amount of 0.75 ml per dose, at a frequency of two or three daily doses.

[0090] For example, the composition can be administered to a patient for the treatment of chronic bronchitis in an amount of 1.65 ml per dose, at a frequency of two or three daily doses.

[0091] For example, the composition can be administered to a patient suffering from immunosuppression, for the preventive or curative treatment of the pathologies mentioned in this description, for example bronchitis, in an amount of 3.5 ml per dose, at a frequency of three daily doses.

[0092] For example, the composition can be administered to a patient suffering from a rheumatic condition in an amount of 1.65 ml per dose, at a frequency of two daily doses.

[0093] In a preferred embodiment, the composition can be administered to a patient for the prevention or treatment of the pathologies mentioned in this description, in an amount of 0.75 ml, twice a day.

[0094] In one embodiment, the composition can be administered to a patient for a period of between 7 and 90 days. Examples

[0095] The detailed examples below illustrate the invention and are in no way a limitation thereof.

[0096] Example 1: Preparation of a composition according to the invention.

[0097] Plant extracts are prepared from buds of Fagus sylvatica, buds of Abies alba Mill., young shoots of Rubus fructicosus L., buds of Corylus avellana, Crataegus oxyacantha buds, Rosa canina young shoots, and Fraxinus excelsior buds.

[0098] Each plant extract is prepared by macerating 100 g of fresh buds or young shoots in 1 kg of a ternary solvent composed of 33% (v / v) water, 33% (v / v) alcohol, 33% (v / v) honey (relative to the total volume of solvent), for 30 days.

[0099] After maceration, the plant extracts are mixed to form a composition according to the following proportions (in mass percentage): - 39% extract of Fagus sylvatica buds, - 25% extract of Abies alba Mill buds, - 15% extract of young shoots of Rubus fructicosus L., - 9% extract of Corylus avellana buds, - 6% Crataegus oxyacantha bud extract, - 3% extract of young Rosa canina shoots, and - 3% extract of Fraxinus excelsior buds.

[0100] Such a composition comprises, for 30 drops (i.e. 1.5 ml), a mass of plant extract (in fresh mass of buds, rootlets and / or young shoots) of 39 mg of Fagus, 24 mg of Abies, 15 mg of Rubus, 9 mg of Corylus, 6 mg of Crataegus, 3 mg of Rosa and 3 mg of Fraxinus.

[0101] The prepared composition was then administered orally to a plurality of patients at different dosages (see examples 2 and 3).

[0102] Example 2: Use of a composition according to the invention for the treatment and prevention of respiratory diseases in a cohort of patients.

[0103] The composition described in Example 1 was administered to a group A of 20 patients with various chronic lung diseases (COPD, winter asthma), during a winter period, at a dosage of 2.5 ml twice a day.

[0104] Patients treated with the composition described in Example 1 did not experience any infectious manifestations during treatment. No side effects were reported during treatment by patients in group A.

[0105] Example 3: Use of a composition according to the invention for the treatment and prevention of various pathologies.

[0106] The composition described in Example 1 was administered to a patient B suffering from immunodeficiencies, and usually experiencing about 6 infectious manifestations per winter, at a dosage of 3.5 ml three times a day.

[0107] Patient B experienced no infectious manifestations during treatment (carried out during the winter period), and a decrease in chronic cough and sputum production was noted. Finally, no side effects were reported by patient B.

Claims

Demands

1. Composition comprising at least six plant extracts selected from: - An extract of Fagus; - An extract of Abies; - An extract of Rubus; - An extract of Corylus; - An extract of Crataegus; - An extract of Rosa; - An extract of Fraxinus; and - An extract of Carpinus.

2. Composition according to claim 1, comprising at least: - An extract of Fagus; - An extract of Abies; - An extract of Rubus; - An extract of Corylus; - An extract of Crataegus; - An extract of Rosa; and - An extract of Fraxinus.

3. Composition according to claim 2, wherein: - The mass proportion of Fagus extract is between 37% and 43%; - The mass proportion of Abies extract is between 21% and 27%; - The mass proportion of Rubus extract is between 12% and 18%; - The mass proportion of Corylus extract is between 6% and 12%; - The mass proportion of Crataegus extract is between 3% and 9%; - The mass proportion of Rosa extract is between 0.5% and 6%; - The mass proportion of Fraxinus extract is between 0.5% and 6%.

4. A composition according to any one of the preceding claims, wherein: - Fagus extract is an extract of the Fagus sylvatica species; - The Abies extract is an extract of a species chosen from Abies alba Mill., Abies balsamea (L.) Mill., and Abies sibirica, preferably Abies alba Mill; - Rubus extract is extracted from a species chosen from Rubus fructicosus L., Rubus caesius L., Rubus chingii var. suavissimus, and Rubus rosa, preferably Rubus fructicosus L.; - Corylus extract is an extract of the Corylus avellana species; - Crataegus extract is an extract of a species chosen from Crataegus oxyacantha, Crataegus curvisepala, Crataegus laevigata, Crataegus monogyna, Crataegus nigra, and Crataegus pentagyna, preferably Crataegus oxyacantha; - Rosa extract is an extract of a species chosen from Rosa canina, Rosa moschata Mill., and Rosa rubiginosa L., preferably Rosa canina; - Fraxinus extract is an extract of the species Fraxinus excelsior.

5. Composition according to any one of the preceding claims, further comprising one or more extracts selected from: - An extract of Alnus, preferably an extract of the species Alnus glutinosa; - An extract of Tilia, preferably an extract of the species Tilia tomentosa; - An extract of Quercus, preferably an extract of the species Quercus robur; - An extract of Juniperus, preferably an extract of the species Juniperus communis; - An extract of Acer, preferably an extract of the species Aces campestris; - An extract of Cornus, preferably an extract of Cornus sanguinea.

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7.

8.

9.

10.

11. Composition according to any one of the preceding claims, wherein the extracts are liquid extracts, preferably honeyed hydroalcoholic liquid extracts. Composition according to any one of the preceding claims, wherein the extracts are extracts obtained from buds, young shoots and / or rootlets. Composition as defined in any one of claims 1 to 7, for use as a medicinal product. Composition as defined in any one of claims 1 to 7, for use in the treatment or prevention of angina, rhinitis, bronchitis, tracheitis, asthma, or pulmonary emphysema. Composition as defined in any one of claims 1 to 7, for use in the treatment or prevention of rheumatism, osteoarthritis, or osteoporosis. Composition as defined in any one of claims 1 to 7, for use in the treatment or prevention of hypercholesterolemia, hyperuricemia, or hyperglycemia.