PARP1 inhibitor compounds

Abstract

A PARP1 inhibitor compound has a structure of: wherein each R1 and R2 is independently absent, H, or an organic group; R3 is H or an organic group; Z1, Z2u, Z2l, and each Z3 is independently C or N; at least one of Z2u and Z2l is N; L is: wherein each R5A, R5B, R5C, and R6 is independently absent, H, or an organic group; each X1 is C or N; each X2 is C, N, O or S; n, m, p, q r and s are each integers in the range 0 to 6; m+n, p+q, and r+s are each in the range 2 to 6; QAE, QAB, and QBC are independently absent or an alkyl, alkenyl, ester, amine, or ketone linker. The compounds are PARP1 inhibitors that are useful for e.g., treating cancer. Also provided are compositions and kits including the compounds, and methods of synthesising the compounds.

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