Skin cleansing formulations

Abstract

Provided is a skin cleansing formulation comprising a dermatologically acceptable vehicle, a dermatologically acceptable oil, and a deposition aid polymer, where the deposition aid polymer is a cationic dextran polymer, including a dextran polymer functionalized with a quaternary ammonium group, and where the deposition aid polymer enhances deposition of the dermatologically acceptable oil from the skin cleansing formulation onto mammalian skin.

Description

Technical Field

[0001] The present invention relates to a skin cleansing formulation. In particular, the present invention relates to a skin cleansing formulation comprising a dermatologically acceptable vehicle, a dermatologically acceptable oil, and a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer comprising a dextran polymer functionalized with a quaternary ammonium group, and the deposition aid polymer enhances the deposition of the dermatologically acceptable oil from the skin cleansing formulation onto mammalian skin.

Background Art

[0002] The deposition of moisturizing agents is of particular interest for various personal care compositions. In particular, there is interest in personal care cleansers (e.g., body washes, facial washes, hand washes, soaps) that provide a moisturizing effect in addition to a cleansing effect.

[0003] Skin cleansing is a ubiquitous element of personal hygiene. Skin cleansing facilitates the removal of dirt, bacteria, and other substances that are recognized as being harmful to the skin or the individual. Cleansing formulations typically include surfactants to facilitate the removal of substances adhering to the skin. Unfortunately, cleansing formulations remove both unwanted and desirable substances from the skin. For example, undesirably, cleansing formulations often remove oils that act to protect the skin from moisture loss. Removing excessive oil from the skin can make the skin prone to dryness. One solution to this concern of skin dryness is the selection of mild surfactants. Another approach is to incorporate additives that help replace the removed oil through deposition, but this approach has proven difficult to implement, particularly in rinse-off applications.

[0004] An approach to enhance the deposition of substances on the skin is disclosed in U.S. Patent Application Publication No. 20100247472 to Sau. Sau discloses an aqueous personal care composition comprising a conditioner and an amino group-functionalized polymer, wherein the amino group is a pendant, and the amino group-functionalized polymer has the following structure:

[0005] [ka] In the formula, the polymer includes a natural polymer, a semi-synthetic polymer, or a synthetic polymer; X includes an oxygen atom, a nitrogen atom, or a sulfur atom, or a polyalkylene oxide group; Y includes a divalent polyalkylene moiety or a substituted divalent polyalkylene moiety; R1 and R2 may be the same or different, and may be hydrogen, C 1~20 Alkyl, C 1~20 Aryl, or C 1~20 It contains an alkyl (aryl) group, n is an integer from 0 to 10, and Z - The formula contains a counter anion, and the conditioner is selected from the group consisting of cationic surfactants, cationic polymers, nucleic acids, lipids, silicones, hydrocarbon oils, fatty acid esters, and combinations thereof.

[0006] Conventional depositing agents such as soluble cationic modified cellulose (e.g., PQ-10), guar hydroxypropyltriammonium chloride, and other cationic polymers (e.g., PQ-6, PQ-7) provide a certain level of oil deposition in personal care cleansers. However, these depositing agents require relatively high oil incorporation into the personal care cleanser formulation to facilitate desired skin moisturizing, and are therefore inefficient. However, such high levels of oil negatively impact the foaming / foaming sensation in the consumer experience of the formulation.

[0007] Therefore, there remains a need for personal care compositions that promote moisturizing while maintaining a desirable user experience for consumers. [Overview of the project]

[0008] The present invention provides a skin cleansing formulation comprising a dermatologically acceptable vehicle, a dermatologically acceptable oil, and a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer containing a dextran polymer functionalized with a quaternary ammonium group, and the deposition aid polymer enhances the deposition of dermatologically acceptable oil from the skin cleansing formulation onto mammalian skin.

[0009] The present invention provides a method for preparing a skin cleansing formulation, comprising: (a) providing a dermatologically acceptable vehicle; (b) providing a dermatologically acceptable oil; (c) selecting a cationic dextran polymer to serve as a deposition aid for enhancing the deposition of the dermatologically acceptable oil on mammalian skin, wherein the cationic dextran polymer includes a dextran polymer functionalized with a quaternary ammonium group; and (d) combining the dermatologically acceptable vehicle, the dermatologically acceptable oil, and the cationic dextran polymer to form a skin cleansing formulation.

[0010] The present invention provides a method for depositing dermatologically acceptable oils onto mammalian skin, comprising providing a skin cleansing formulation according to the present invention, and applying the skin cleansing formulation to the skin of a mammal. [Modes for carrying out the invention]

[0011] The inventors have surprisingly discovered a cationic dextran polymer functionalized with a quaternary ammonium group, in which the deposition aid polymer enhances the deposition of dermatologically acceptable oils from skin cleansing formulations onto mammalian skin. This allows for moisturizing while maintaining a desirable consumer feel during use.

[0012] Unless otherwise specified, ratios, percentages, and parts are expressed by weight.

[0013] Where used herein, unless otherwise indicated, "molecular weight" or M W The term refers to the weight-average molecular weight measured by conventional methods using gel permeation chromatography (GPC) and poly(ethylene oxide) standards. The GPC technique is described in detail in *Modem Size Exclusion Chromatography*, WWYau, JJ Kirkland, DDBly; Wiley-Interscience, 1979, and *A Guide to Materials Characterization and Chemical Analysis*, JPSibilia; VCH, 1988, pp. 81-84. Molecular weight is reported herein in units of Daltons or equivalently in g / mol.

[0014] As used herein and in the appendices, the term “dermatologically acceptable” refers to ingredients typically used for topical application to the skin, and it is intended to emphasize that materials that are toxic when present in amounts typically found in skincare compositions are not intended as part of the present invention.

[0015] Preferably, the skin cleansing formulation of the present invention is selected from the group consisting of body wash formulations, exfoliating body wash formulations, facial cleanser formulations, exfoliating facial cleanser formulations, liquid hand soap, soap, sulfate-free cleansing formulations, and mild cleansing formulations. More preferably, the skin cleansing formulation of the present invention is selected from the group consisting of body wash formulations, facial cleanser formulations, and liquid hand soap. Most preferably, the skin cleansing formulation of the present invention is a body wash formulation.

[0016] Preferably, the skin cleansing formulation of the present invention contains a dermatologically acceptable vehicle (preferably, the skin cleansing formulation contains 25 to 99% by weight (preferably 30 to 95% by weight, more preferably 40 to 90% by weight, most preferably 70 to 85% by weight) of a dermatologically acceptable vehicle based on the weight of the skin cleansing formulation) (preferably, the dermatologically acceptable vehicle contains water, and more preferably, the dermatologically acceptable vehicle contains water and aqueous C 1~4 A skin cleansing formulation is selected from the group consisting of alcohol mixtures, most preferably water being a dermatologically acceptable vehicle, and a dermatologically acceptable oil (preferably the skin cleansing formulation contains 1 to 25% by weight (preferably 2 to 20% by weight, more preferably 2.5 to 15% by weight, most preferably 4 to 6% by weight) of dermatologically acceptable oil based on the weight of the skin cleansing formulation) (preferably the dermatologically acceptable oil is selected from the group consisting of hydrocarbon oils (e.g., mineral oil, petrolatum, polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, polyisohexadecane, natural oils (e.g., caprylic and capric triglycerides, sunflower oil, soybean oil, coconut oil), fragrance oils (e.g., limonene), and mixtures thereof) The selected, and more preferably, dermatologically acceptable oils include natural oils, and most preferably, dermatologically acceptable oils are sunflower oils. The formulation also includes a deposition aid polymer (preferably, the skin cleansing formulation contains 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a cationic dextran polymer based on the weight of the skin cleansing formulation), wherein the deposition aid polymer is a cationic dextran polymer, including a dextran polymer functionalized with quaternary ammonium groups, and the deposition aid polymer enhances the deposition of dermatologically acceptable oils from the skin cleansing formulation onto mammalian skin.

[0017] Preferably, the skin cleansing formulation of the present invention is a liquid formulation. Most preferably, the skin cleansing formulation of the present invention is an aqueous liquid formulation.

[0018] Preferably, the skin cleansing formulation of the present invention contains less than 0.001% by weight of silicone, based on the weight of the skin cleansing formulation. More preferably, the skin cleansing formulation of the present invention contains less than 0.0001% by weight of silicone, based on the weight of the skin cleansing formulation. Most preferably, the skin cleansing formulation of the present invention contains silicone below the detectable limit. Examples of silicones include dimethylpolysiloxane, methylphenylpolysiloxane, polyether-modified silicone oil, and polyamino-modified silicone oil.

[0019] Preferably, the skin cleansing formulation of the present invention contains a dermatologically acceptable vehicle. More preferably, the skin cleansing formulation of the present invention contains 25 to 99% by weight (preferably 30 to 95% by weight, more preferably 40 to 90% by weight, most preferably 70 to 85% by weight) of a dermatologically acceptable vehicle based on the weight of the skin cleansing formulation. Even more preferably, the skin cleansing formulation of the present invention contains 25 to 99% by weight (preferably 30 to 95% by weight, more preferably 40 to 90% by weight, most preferably 70 to 85% by weight) of a dermatologically acceptable vehicle based on the weight of the skin cleansing formulation, and the dermatologically acceptable vehicle includes water. More preferably, the skin cleansing formulation of the present invention comprises 25 to 99% by weight (preferably 30 to 95% by weight, more preferably 40 to 90% by weight, most preferably 70 to 85% by weight) of a dermatologically acceptable vehicle, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable vehicle is water and aqueous C 1~4 The alcohol mixture is selected from the group consisting of alcohol mixtures. Most preferably, the skin cleansing formulation of the present invention contains 25 to 99% by weight (preferably 30 to 95% by weight, more preferably 40 to 90% by weight, most preferably 70 to 85% by weight) of a dermatologically acceptable vehicle, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable vehicle is water.

[0020] Preferably, the water used in the skin cleansing formulation of the present invention is at least one of distilled water and deionized water. More preferably, the water used in the skin cleansing formulation of the present invention is distilled and deionized.

[0021] Preferably, the skin cleansing formulation of the present invention contains dermatologically acceptable oils. More preferably, the skin cleansing formulation of the present invention contains 1 to 25% by weight (preferably 2 to 20% by weight, more preferably 2.5 to 15% by weight, most preferably 4 to 6% by weight) of dermatologically acceptable oils based on the weight of the skin cleansing formulation. More preferably, the skin cleansing formulation of the present invention contains 1 to 25% by weight (preferably 2 to 20% by weight, more preferably 2.5 to 15% by weight, most preferably 4 to 6% by weight) of dermatologically acceptable oils based on the weight of the skin cleansing formulation, and the dermatologically acceptable oils are selected from the group consisting of hydrocarbon oils (e.g., mineral oil, petrolatum, polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, polyisohexadecane, natural oils (e.g., caprylic and capric triglycerides, sunflower oil, soybean oil, coconut oil, argan oil, olive oil, almond oil)), fragrance oils (e.g., limonene), and mixtures thereof. More preferably, the skin cleansing formulation of the present invention contains 1 to 25% by weight (preferably 2 to 20% by weight, more preferably 2.5 to 15% by weight, most preferably 4 to 6% by weight) of a dermatologically acceptable oil, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil includes at least one of petrolatum, mineral oil, and sunflower oil. Most preferably, the skin cleansing formulation of the present invention contains 1 to 25% by weight (preferably 2 to 20% by weight, more preferably 2.5 to 15% by weight, most preferably 4 to 6% by weight) of a dermatologically acceptable oil, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil is sunflower oil.

[0022] Preferably, the skin cleansing formulation of the present invention comprises a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer containing a dextran polymer functionalized with quaternary ammonium groups, and the deposition aid polymer enhances the deposition of dermatologically acceptable oils from the skin cleansing formulation onto mammalian skin. More preferably, the skin cleansing formulation of the present invention comprises 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of the deposition aid polymer based on the weight of the skin cleansing formulation, wherein the deposition aid polymer is a cationic dextran polymer containing a dextran polymer functionalized with quaternary ammonium groups, and the deposition aid polymer enhances the deposition of dermatologically acceptable oils from the skin cleansing formulation onto mammalian skin. Most preferably, the skin cleansing formulation of the present invention comprises 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer based on the weight of the skin cleansing formulation, wherein the deposition aid polymer is a cationic dextran polymer containing a dextran polymer functionalized with quaternary ammonium groups, and the deposition aid polymer has a Kjeldahl nitrogen content of 0.5 to 4.0% by weight (preferably 0.75 to 3.25% by weight, more preferably 0.9 to 2.6% by weight, most preferably 1 to 2.0% by weight), corrected for ash and volatile substances, i.e., TKN (measured using a Buchi KjelMaster K-375 automated analyzer as described in ASTM Method D-2364, corrected for volatile substances and ash), and the deposition aid polymer enhances the deposition of dermatologically acceptable oils from the skin cleansing formulation onto mammalian skin.

[0023] Preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety. More preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, and the dextran polymer is a branched-chain dextran polymer. Even more preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, the dextran polymer contains a branched-chain dextran polymer, the branched-chain dextran polymer contains a plurality of glucose structural units, and 90-98 mol% (preferably 92.5-97.5 mol%, more preferably 93-97 mol%, most preferably 94-96 mol%) of the glucose structural units are α-D-1,6 linkages, and 2-10 mol% (preferably 2.5-7.5 mol%, more preferably 3-7 mol%, most preferably 4-6 mol%) of the glucose structural units are connected by α-1,3 linkages. Most preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, the dextran polymer is a branched-chain dextran polymer, the branched-chain dextran polymer contains a plurality of glucose structural units, and 90-98 mol% (preferably 92.5-97.5 mol%, more preferably 93-97 mol%, most preferably 94-96 mol%) of the glucose structural units are α-D-1,6 linkages, and 2-10 mol% (preferably 2.5-7.5 mol%, more preferably 3-7 mol%, most preferably 4-6 mol%) of the glucose structural units are connected by α-1,3 linkages according to formula (i),

[0024] [Chemical formula] In the formula, R is selected from hydrogen, C 1~4 alkyl group, and hydroxy C 1~4 alkyl group, and the average degree of branching from the dextran polymer backbone is ≦3 anhydroglucose units.

[0025] Preferably, the dextran polymer contains less than 0.01% by weight of the dextran polymer, based on the weight of the dextran polymer. More preferably, the dextran polymer contains less than 0.001% by weight of the dextran polymer, based on the weight of the dextran polymer. Most preferably, the dextran polymer contains less than the detectable limit of the alternane.

[0026] Preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, wherein the quaternary ammonium moiety is (a) a dextran crosslinking group of formula (A).

[0027] [ka] and (b) Quaternary ammonium group of formula (B)

[0028] [ka]

[0029] Selected from the group consisting of at least one of the following, in the formula,

[0030] [ka] This is the pendant oxygen on the dextran polymer, and each R 1 These are independently substituted or non-substituted C 1~6 Selected from alkyl groups ("substituted" means that the group contains at least one of halogen, hydroxyl, amino, or carboxyl groups) (preferably each R 1 Independently, non-substituted C 1~6 Selected from alkyl groups, more preferably each R 1 R is independently selected from the group consisting of methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, tert-butyl group, sec-butyl group, pentyl group, isopentyl group, neopentyl group, hexyl group, and isohexyl group, and more preferably each R 1R is independently selected from the group consisting of methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, tert-butyl group, and sec-butyl group, and more preferably each R 1 R is independently selected from the group consisting of methyl, ethyl, propyl, and isopropyl groups, and more preferably each R 1 These are independently selected from the group consisting of methyl groups and ethyl groups, most preferably each R 1 ( is a methyl group), each R 2 Independently, C 1~6 Selected from the group consisting of alkanediyl groups (preferably each R 2 Independently, C 1~4 Selected from the group consisting of alkanediyl groups, more preferably each R 2 Independently, C 1~2 Selected from the group consisting of alkanediyl groups, most preferably each R 2 (where is a -CH2- group), and Y is a divalent crosslinking group (preferably Y is C 1~6 Alkanediyl group and -R 3 -OR 4 -A divalent crosslinking group selected from the group consisting of -R 3 -OR 4 - is a base), R 3 and R 4 Independently, C 1~6 Selected from the group consisting of alkanediyl groups (preferably, R 3 and R 4 Independently, C 1~4 Selected from the group consisting of alkanediyl groups, more preferably R 3 and R 4 Independently, C 1~3 Selected from the group consisting of alkanediyl groups, most preferably R 3 and R 4 Both are -CH2CH2- groups) (preferably R 3 and R 4X is a divalent linking group that bonds the quaternary ammonium moiety to the pendant oxygen on the dextran polymer (preferably, X is selected from divalent hydrocarbon groups, which may optionally be substituted (e.g., with a hydroxyl group, alkoxy group, or ether group), and more preferably, X is -CH2CH(OR 6 )CH2- group, R 6 is hydrogen and C 1~4 Selected from the group consisting of alkyl groups, most preferably X is a -CH2CH(OH)CH2- group), each R 5 Independently, C 1~22 Selected from the group consisting of alkyl groups (preferably each R 5 C 1~3 Alkyl and C 6~22 Selected from the group consisting of alkyl groups, more preferably each R 5 These are independently selected from the group consisting of methyl groups and ethyl groups, most preferably each R 5 (This is a methyl group.)

[0031] More preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, wherein the quaternary ammonium moiety is selected from the group consisting of at least one of (a) a dextran crosslinking group of formula (A) and (b) a quaternary ammonium group of formula (B), and the dextran crosslinking group of formula (A) is the group of formula (C).

[0032] [ka] The quaternary ammonium group in formula (B) is the same as the group in formula (D),

[0033] [ka] During the ceremony,

[0034] [ka] This is the pendant oxygen on the dextran polymer, and each R1 These are independently substituted or non-substituted C 1~6 Selected from alkyl groups ("substituted" means that the group contains at least one portion selected from halogen, hydroxyl, amino, or carboxyl groups) (preferably each R 1 Independently, non-substituted C 1~6 Selected from alkyl groups, more preferably each R 1 R is independently selected from the group consisting of methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, tert-butyl group, sec-butyl group, pentyl group, isopentyl group, neopentyl group, hexyl group, and isohexyl group, and more preferably each R 1 R is independently selected from the group consisting of methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, tert-butyl group, and sec-butyl group, and more preferably each R 1 R is independently selected from the group consisting of methyl, ethyl, propyl, and isopropyl groups, and more preferably each R 1 These are independently selected from the group consisting of methyl groups and ethyl groups, most preferably each R 1 ( is a methyl group), each R 2 Independently, C 1~6 Selected from the group consisting of alkanediyl groups (preferably each R 2 Independently, C 1~4 An alkanediyl group, more preferably each R 2 C 1~2 It is an alkanediyl group, most preferably each R 2 (This is a -CH2- group), R 3 and R 4 Independently, C 1~6 Selected from the group consisting of alkanediyl groups (preferably, R 3 and R 4 Independently, C 1~4 Selected from the group consisting of alkanediyl groups, more preferably R 3 and R 4 Independently, C 1~3Selected from the group consisting of alkanediyl groups, most preferably -CH2CH2- groups) (preferably R 3 and R 4 (They are the same), each R 6 is hydrogen and C 1~4 Selected from the group consisting of alkyl groups (preferably R 6 (is hydrogen), each R 7 This is independently selected from the group consisting of methyl groups and ethyl groups (preferably a methyl group).

[0035] More preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, wherein the quaternary ammonium moiety is selected from the group consisting of at least one of (a) a dextran crosslinking group of formula (A) and (b) a quaternary ammonium group of formula (B), and the dextran crosslinking group of formula (A) is

[0036] [ka]

[0037] [ka] Selected from the group consisting of and mixtures thereof, the quaternary ammonium group of formula (B) is the group of formula (D), in which,

[0038] [ka] This is the pendant oxygen on the dextran polymer, and each R 6 is hydrogen and C 1~4 Selected from the group consisting of alkyl groups (preferably R 6 (is hydrogen), each R 7 This is independently selected from the group consisting of methyl groups and ethyl groups (preferably a methyl group).

[0039] Most preferably, the deposition aid polymer is a dextran polymer functionalized with a quaternary ammonium moiety, and the quaternary ammonium moiety is selected from the group consisting of quaternary ammonium groups of formula (b) (D), where

[0040] [Chemical Formula] is a pendant oxygen on the dextran polymer, and each R 6 is selected from the group consisting of hydrogen and C 1~4 alkyl groups (preferably, R 6 is hydrogen), and each R 7 is independently selected from the group consisting of methyl and ethyl groups (preferably, a methyl group).

[0041] Preferably, the deposition aid polymer contains aldehyde functional groups of <0.001 meq / gram (preferably, <0.0001 meq / gram, more preferably, <0.00001 meq / gram, most preferably, <detection limit).

[0042] Preferably, the deposition aid polymer contains bonds between individual glucose units in the deposition aid polymer that are β-1,4 linkages of <0.1% (preferably, <0.01%, more preferably, <0.001%, most preferably, <detection limit).

[0043] Preferably, the deposition aid polymer contains bonds between individual glucose units in the deposition aid polymer that are β-1,3 linkages of <0.1% (preferably, <0.01%, more preferably, <0.001%, most preferably, <detection limit).

[0044] Preferably, the deposition aid polymer contains silicone-containing functional groups of <0.001 meq / gram (preferably, <0.0001 meq / gram, more preferably, <0.00001 meq / gram, most preferably, <detection limit).

[0045] Preferably, the deposition aid polymer contains <0.1 mol% (preferably 0 to <0.01 mol%, more preferably 0 to <0.001 mol%, most preferably 0 to < the detection limit) of reactive siloxane structural units, the reactive siloxane structural units containing a Si-O moiety. More preferably, the deposition aid polymer contains <0.1 mol% (preferably 0 to <0.01 mol%, more preferably 0 to <0.001 mol%, most preferably 0 to < the detection limit) of reactive siloxane structural units, the reactive siloxane structural units containing a Si-O moiety, and the reactive siloxane is a polymer that may contain one or more functional moieties selected from the group consisting of amino, amide, alkoxy, hydroxy, polyether, carboxy, hydride ions, mercapto, sulfate ions, phosphate ions, and / or quaternary ammonium moieties, these moieties may be directly bonded to the siloxane skeleton via divalent alkylene radicals (i.e., pendants) or may be part of the skeleton.

[0046] Preferably, the skin cleansing formulation of the present invention further comprises a dermatologically acceptable personal care cleansing surfactant. More preferably, the skin cleansing formulation of the present invention further comprises 0.01 to 80% by weight (preferably 5 to 50% by weight, more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of a dermatologically acceptable personal care cleansing surfactant, based on the weight of the skin cleansing formulation. More preferably, the skin cleansing formulation of the present invention further comprises 0.01 to 80% by weight (preferably 5 to 50% by weight, more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of dermatologically acceptable personal care cleansing surfactants based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable personal care cleansing surfactants are alkyl polyglucosides (e.g., lauryl glucoside, coco-glucoside, decyl glucoside), glycinates (e.g., sodium cocoyl glycinate), betaines (e.g., alkyl betaines such as cetyl betaine and coco Amidopropyl betaine (such as camidopropyl betaine), taurate (e.g., sodium methylcocoyl taurate), glutamate (e.g., sodium cocoyl glutamate), sarcosinate (e.g., sodium lauroyl sarcosinate), isethionate (e.g., sodium cocoyl isethionate, sodium lauroyl methyl isethionate), sulfoacetate (e.g., sodium lauryl sulfoacetate), alaninate (e.g., sodium cocoyl alanine), amfoacetate (e.g., sodium cocoamphoacetate), sulfate (e.g., sodium laureth sulfate), sulfonate (e.g., C 14~16The following are selected from the group consisting of sodium olefin sulfonate, succinate (e.g., disodium lauryl sulfosuccinate), and mixtures thereof. Most preferably, the skin cleansing formulation of the present invention further comprises 0.01 to 80% by weight (preferably 5 to 50% by weight, more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of a dermatologically acceptable personal care cleansing surfactant, based on the weight of the skin cleansing formulation, the dermatologically acceptable personal care cleansing surfactant includes a mixture of sodium laureth sulfate (SLES) and cocamidopropyl betaine.

[0047] Preferably, the skin cleansing formulation of the present invention optionally contains an antibacterial agent, a rheological modifier, soap, a colorant, a pH adjuster, an antioxidant (e.g., butylated hydroxytoluene), a humectant (e.g., glycerin, sorbitol, monoglycerides, lecithin, glycolipids, fatty alcohols, fatty acids, polysaccharides, sorbitan esters, polysorbates (e.g., polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80), a diol (e.g., propylene glycol), a diol analog, and The present invention further comprises at least one additional component selected from the group consisting of triols, triol analogs, cationic polymeric polyols, waxes, foaming agents, emulsifiers, fragrances, chelating agents, preservatives (e.g., benzoic acid, sorbic acid, phenoxyethanol), bleaching agents, lubricants, sensory modifiers, sunscreen additives, vitamins, proteins / amino acids, plant extracts, natural ingredients, bioactives, degradation inhibitors, penetrating agents, antistatic agents, absorbents, hard particles, soft particles, lubricants, opacifiers, pearlescent agents, salts, and mixtures thereof. More preferably, the skin cleansing formulation of the present invention further optionally comprises at least one additional component selected from the group consisting of at least one antimicrobial agent, dermatologically acceptable personal care cleansing surfactant, rheology modifier, soap, colorant, and pH adjuster.

[0048] Preferably, the skin cleansing formulation of the present invention further comprises an antibacterial agent. Most preferably, the skin cleansing formulation of the present invention further comprises an antibacterial agent selected from the group consisting of phenoxyethanol, benzoic acid, benzyl alcohol, sodium benzoate, DMDM ​​hydantoin, 2-ethylhexylglyceryl ether, and isotiazolinone (e.g., methylchloroisothiazolinone, methylisothiazolinone). Even more preferably, the skin cleansing formulation of the present invention further comprises an antibacterial agent, the antibacterial agent being isotiazolinone (more preferably, the antibacterial agent is selected from the group consisting of methylisothiazolinone, methylchloroisothiazolinone, and mixtures thereof, and most preferably, the biocide is methylisothiazolinone). Most preferably, the skin cleansing formulation of the present invention further comprises an antibacterial agent, the antibacterial agent being isotiazolinone (more preferably, the antibacterial agent is selected from the group consisting of methylisothiazolinone, methylchloroisothiazolinone, and mixtures thereof, most preferably the antibacterial agent being methylisothiazolinone), and the skin cleansing formulation is a body wash formulation.

[0049] Preferably, the skin cleansing formulation of the present invention further comprises soap. More preferably, the skin cleansing formulation of the present invention further comprises soap, the soap being selected from the group consisting of sodium stearate, sodium laurate, sodium tallowate, sodium palmitate, potassium stearate, potassium laurate, potassium tallowate, potassium palmitate, and mixtures thereof. Even more preferably, the skin cleansing formulation of the present invention further comprises soap, the soap being selected from the group consisting of sodium stearate, sodium laurate, potassium stearate, potassium laurate, and mixtures thereof. Even more preferably, the skin cleansing formulation of the present invention further comprises soap, the soap being selected from the group consisting of sodium stearate, potassium stearate, and mixtures thereof. Most preferably, the skin cleansing formulation of the present invention further comprises soap, the soap being sodium stearate.

[0050] Preferably, the skin cleansing formulation of the present invention further comprises soap, the soap being selected from the group consisting of sodium stearate, sodium laurate, sodium talusate, sodium palmitate, potassium stearate, potassium laurate, potassium talusate, potassium palmitate, and mixtures thereof (more preferably, the soap being selected from the group consisting of sodium stearate, sodium laurate, potassium stearate, potassium laurate, and mixtures thereof; even more preferably, the soap being selected from the group consisting of sodium stearate, potassium stearate, and mixtures thereof; most preferably, the soap being sodium stearate), and the skin cleansing formulation is a body wash formulation.

[0051] Preferably, the skin cleansing formulation of the present invention further comprises a rheological modifier. More preferably, the skin cleansing formulation of the present invention further comprises a rheological modifier, the rheological modifier being selected from the group consisting of sodium chloride, cellulose, xanthan gum, acrylate copolymers, and mixtures thereof. Even more preferably, the skin cleansing formulation of the present invention further comprises a rheological modifier, the rheological modifier comprising an acrylate copolymer, the acrylate copolymer being an ionic acrylic rheological modifier. Even more preferably, the skin cleansing formulation of the present invention further comprises a rheological modifier, the rheological modifier being an acrylate copolymer, an alkali-swelling anionic acrylic copolymer (e.g., Aculyn® 33, Aculyn® 22, Aculyn® 28, Aculyn® 88 rheological modifiers, all available from The Dow Chemical Company). Most preferably, the skin cleansing formulation of the present invention further comprises a rheological modifier, the skin cleansing formulation being a body wash formulation, and the rheological modifier being an alkali-swelling anionic acrylic copolymer (e.g., Aculyn® 33, Aculyn® 22, Aculyn® 28, Aculyn® 88 rheological modifiers, all available from The Dow Chemical Company).

[0052] Preferably, the skin cleansing formulation of the present invention further comprises a pH adjusting agent. More preferably, the skin cleansing formulation of the present invention further comprises a pH adjusting agent, and the skin cleansing formulation is a body wash formulation. Most preferably, the skin cleansing formulation of the present invention further comprises a pH adjusting agent, and the skin cleansing formulation is a body wash formulation, and the body wash formulation has a pH of 4.5 to 9 (preferably 5 to 8, most preferably 6 to 7).

[0053] Preferably, the pH adjusting agent is selected from the group consisting of at least one of citric acid, lactic acid, hydrochloric acid, aminoethylpropanediol, triethanolamine, monoethanolamine, sodium hydroxide, potassium hydroxide, and amino-2-methyl-1-propanol. More preferably, the pH adjusting agent is selected from the group consisting of at least one of citric acid, lactic acid, sodium hydroxide, potassium hydroxide, triethanolamine, and amino-2-methyl-1-propanol. Even more preferably, the pH adjusting agent includes triethanolamine. Most preferably, the pH adjusting agent is triethanolamine.

[0054] Preferably, the skin cleansing formulation of the present invention further comprises a coloring agent. More preferably, the skin cleansing formulation of the present invention further comprises a coloring agent, and the skin cleansing formulation is a body wash formulation.

[0055] Preferably, the skin cleansing formulation of the present invention is a body wash formulation. More preferably, the skin cleansing formulation of the present invention is a body wash formulation and comprises, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water), 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, where the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and, based on the weight of the skin cleansing formulation, 0.05 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of a dermatologically acceptable oil. More preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water), and based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer is a quaternary ammonia The formulation comprises a deposition aid polymer which is a cationic dextran polymer functionalized with a dextran group, and 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of dermatologically acceptable oils, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oils are selected from the group consisting of hydrocarbon oils (e.g., mineral oil, petrolatum), natural oils (e.g., sunflower oil, soybean oil, coconut oil), silicone oils (e.g., polydimethylsiloxane), fragrance oils (e.g., limonene), and mixtures thereof.More preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water) and, based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposit-adding polymer. The deposition aid polymer is a cationic dextran polymer containing dextran functionalized with a quaternary ammonium group, and the formulation comprises 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of a dermatologically acceptable oil, based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil is selected from the group consisting of at least one of mineral oil, petrolatum, sunflower oil, soybean oil, coconut oil, silicone oil, and fragrance oil. Even more preferably, the skin cleansing formulation of the present invention is a body wash formulation, comprising 25-99% by weight (preferably 30-90% by weight, more preferably 60-85% by weight, most preferably 75-80% by weight) of a dermatologically acceptable vehicle (preferably water) based on the weight of the skin cleansing formulation, and 0.05-5% by weight (preferably 0.1-2.5% by weight, more preferably 0.2-1% by weight, most preferably) based on the weight of the skin cleansing formulation. The formulation comprises a deposition aid polymer in an amount of 0.35 to 0.75% by weight, wherein the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and a dermatologically acceptable oil in an amount of 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil includes sunflower oil.Most preferably, the skin cleansing formulation of the present invention is a body wash formulation, comprising 25-99% by weight (preferably 30-90% by weight, more preferably 60-85% by weight, most preferably 75-80% by weight) of a dermatologically acceptable vehicle (preferably water) based on the weight of the skin cleansing formulation, and 0.05-5% by weight (preferably 0.1-2.5% by weight, more preferably 0.2-1% by weight, most preferably) based on the weight of the skin cleansing formulation. The formulation comprises a deposition aid polymer in an amount of 0.35 to 0.75% by weight, wherein the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and a dermatologically acceptable oil in an amount of 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight), based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil is sunflower oil.

[0056] Preferably, the skin cleansing formulation of the present invention is a body wash formulation. More preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water) and, based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer The formulation comprises a deposition aid polymer, which is a cationic dextran polymer functionalized with a quaternary ammonium group; 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of dermatologically acceptable oil, based on the weight of the skin cleansing formulation; and 0.01 to 80% by weight (preferably 5 to 50% by weight, more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of dermatologically acceptable personal care cleansing surfactant, based on the weight of the skin cleansing formulation. More preferably, the skin cleansing formulation of the present invention is a body wash formulation, comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water), and, based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and, based on the weight of the skin cleansing formulation, 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7%).5% by weight of a dermatologically acceptable oil, the dermatologically acceptable oil being selected from the group consisting of hydrocarbon oils (e.g., mineral oil, petrolatum), natural oils (e.g., sunflower oil, soybean oil, coconut oil), silicone oils (e.g., polydimethylsiloxane), fragrance oils (e.g., limonene), and mixtures thereof, and 0.01 to 80% by weight (more preferably 5 to 50% by weight, even more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of a dermatologically acceptable personal care cleansing surfactant, the dermatologically acceptable personal care cleansing surfactant being alkyl polyglucosides (e.g., lauryl glucoside, coco-glucoside, etc.) (Syl glucoside), glycinate (e.g., sodium cocoyl glycinate), betaine (e.g., alkyl betaines such as cetyl betaine and amide betaines such as cocamidopropyl betaine), taurate (e.g., sodium methyl cocoyl taurate), glutamate (e.g., sodium cocoyl glutamate), sarcosinate (e.g., sodium lauroyl sarcosinate), isethionate (e.g., sodium cocoyl isethionate, sodium lauroyl methyl isethionate), sulfoacetate (e.g., sodium lauryl sulfoacetate), alaninate (e.g., sodium cocoyl alanine), amfoacetate (e.g., sodium cocoamphoacetate), sulfate (e.g., sodium laureth sulfate), sulfonate (e.g., C. 14~16The present invention comprises a dermatologically acceptable personal care cleansing surfactant selected from the group consisting of sodium olefin sulfonate, succinate (e.g., disodium lauryl sulfosuccinate), and mixtures thereof. More preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water), and based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer is functionalized with quaternary ammonium groups. A deposition aid polymer which is a cationic dextran polymer containing modified dextran, and a dermatologically acceptable oil in an amount of 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) based on the weight of the skin cleansing formulation, wherein the dermatologically acceptable oil is selected from the group consisting of at least one of mineral oil, petrolatum, sunflower oil, soybean oil, coconut oil, silicone oil, and fragrance oil, and an amount of 0.01 to 80% by weight (more preferably 5 to 50% by weight, even more preferably 7%) based on the weight of the skin cleansing formulation.The skin cleansing formulation is a body wash formulation comprising 5-35% by weight, most preferably 10-20% by weight, of dermatologically acceptable personal care cleansing surfactants, and the dermatologically acceptable personal care cleansing surfactants include alkyl polyglucosides (e.g., lauryl glucoside, coco-glucoside, decyl glucoside), glycinates (e.g., sodium cocoyl glycinate), betaines (e.g., alkyl betaines such as cetyl betaine and amide betaines such as cocamidopropyl betaine), taurate (e.g., sodium methylcocoyl taurate), glutamate (e.g., sodium cocoyl glutamate), sarcosinate (e.g., sodium lauroyl sarcosinate), isethionate (e.g., sodium cocoyl isethionate, sodium lauroyl methyl isethionate), sulfoacetate (e.g., sodium lauryl sulfoacetate), alaninate (e.g., sodium cocoyl alanine), amfoacetate (e.g., sodium cocoamphoacetate), sulfate (e.g., sodium laureth sulfate), sulfonate (e.g., C. 14~16The following are selected from the group consisting of sodium olefin sulfonate, succinate (e.g., disodium lauryl sulfosuccinate), and mixtures thereof. More preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water), and, based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and the skin cleansing formulation The formulation comprises 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of dermatologically acceptable oils, the dermatologically acceptable oils including mineral oil, and 0.01 to 80% by weight (more preferably 5 to 50% by weight, even more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of dermatologically acceptable personal care cleansing surfactants, the dermatologically acceptable formulation being a body wash formulation, and the dermatologically acceptable personal care cleansing surfactants including a mixture of sodium laureth sulfate (SLES) and cocamidopropyl betaine.Most preferably, the skin cleansing formulation of the present invention is a body wash formulation comprising, based on the weight of the skin cleansing formulation, 25 to 99% by weight (preferably 30 to 90% by weight, more preferably 60 to 85% by weight, most preferably 75 to 80% by weight) of a dermatologically acceptable vehicle (preferably water) and, based on the weight of the skin cleansing formulation, 0.05 to 5% by weight (preferably 0.1 to 2.5% by weight, more preferably 0.2 to 1% by weight, most preferably 0.35 to 0.75% by weight) of a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer containing dextran functionalized with quaternary ammonium groups, and the weight of the skin cleansing formulation The skin cleansing formulation comprises 0.5 to 40% by weight (preferably 1 to 15% by weight, more preferably 2.5 to 7.5% by weight) of a dermatologically acceptable oil, where the dermatologically acceptable oil is sunflower oil, and 0.01 to 80% by weight (more preferably 5 to 50% by weight, even more preferably 7.5 to 35% by weight, most preferably 10 to 20% by weight) of a dermatologically acceptable personal care cleansing surfactant, where the skin cleansing formulation is a body wash formulation, and the dermatologically acceptable personal care cleansing surfactant comprises a mixture of sodium laureth sulfate (SLES) and cocamidopropyl betaine.

[0057] Preferably, a method for producing a skin cleansing formulation of the present invention comprises (a) providing a dermatologically acceptable vehicle, (b) providing a dermatologically acceptable oil, (c) selecting a cationic dextran polymer as a deposition aid to enhance the deposition of the dermatologically acceptable oil on mammalian skin, wherein the cationic dextran polymer includes a dextran polymer functionalized with a quaternary ammonium group, (d) providing the selected cationic dextran polymer, and (d) combining the dermatologically acceptable vehicle, the dermatologically acceptable oil, and the cationic dextran polymer to form a skin cleansing formulation. More preferably, a method for producing a skin cleansing formulation of the present invention comprises: (a) providing a dermatologically acceptable vehicle; (b) providing a dermatologically acceptable oil; (c) providing a dermatologically acceptable personal care cleansing surfactant; (d) selecting a cationic dextran polymer as a deposition aid to enhance the deposition of the dermatologically acceptable oil on mammalian skin, wherein the cationic dextran polymer includes a dextran polymer functionalized with a quaternary ammonium group; (e) providing a selected cationic dextran polymer; and (f) combining a dermatologically acceptable vehicle, a dermatologically acceptable oil, a dermatologically acceptable personal care cleansing surfactant, and a cationic dextran polymer to form a skin cleansing formulation.Most preferably, a method for producing the skin cleansing formulation of the present invention comprises (a) providing a dermatologically acceptable vehicle, (b) providing a dermatologically acceptable oil, (c) providing a dermatologically acceptable personal care cleansing surfactant, and (d) selecting from the group consisting of antimicrobial agents, rheological modifiers, soaps, colorants, pH adjusters, antioxidants, humectants, waxes, foaming agents, emulsifiers, fragrances, chelating agents, preservatives, bleaching agents, lubricants, sensory modifiers, sunscreen additives, vitamins, proteins / amino acids, plant extracts, natural ingredients, bioactives, anti-aging agents, penetrating agents, antistatic agents, absorbents, hard particles, soft particles, lubricants, milking agents, pearlescent agents, and salts. The present invention comprises providing at least one additional component, (e) selecting a cationic dextran polymer as a deposition aid to enhance the deposition of dermatologically acceptable oils onto mammalian skin, wherein the cationic dextran polymer includes a dextran polymer functionalized with a quaternary ammonium group, (f) providing a selected cationic dextran polymer, and (g) combining a dermatologically acceptable vehicle, a dermatologically acceptable oil, a dermatologically acceptable personal care cleansing surfactant, at least one additional component, and a cationic dextran polymer to form a skin cleansing formulation.

[0058] Preferably, the method of the present invention for depositing dermatologically acceptable oils on mammalian skin comprises providing a skin cleansing formulation of the present invention and applying the skin cleansing formulation to mammalian skin. More preferably, the method of the present invention for depositing dermatologically acceptable oils on mammalian skin further comprises rinsing the skin cleansing formulation from the mammalian skin with rinse water. Most preferably, the method of the present invention for depositing dermatologically acceptable oils on mammalian skin comprises selecting a skin cleansing formulation of the present invention, applying the skin cleansing formulation to mammalian skin, and rinsing the skin cleansing formulation from the mammalian skin, wherein the skin cleansing formulation is preferably a body wash (preferably at least 10% by weight (more preferably at least 12% by weight, most preferably at least 15% by weight) of dermatologically acceptable oils from the skin cleansing formulation deposited on the mammalian skin).

[0059] Several embodiments of the present invention will be described in detail in the following examples.

[0060] Example S1: Synthesis of cationic dextran polymer A 500 mL four-necked round-bottom flask fitted with a rubber ceramic cap, nitrogen inlet, pressure equalization funnel, stirring paddle and motor, subsurface thermocouple connected to a J-KEM controller, and a Friedrich condenser connected to a mineral oil bubbler was used to add dextran (30.59 g, Sigma / Aldrich product D4876, molecular weight 130-170 kDa) and deionized water (140.75 g). A 70% aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (27.14 g, QUAB® 151, available from SKW QUAB Chemicals) was added to the addition funnel. The contents of the flask were stirred until the dextran dissolved in the deionized water. While stirring the contents, the apparatus was purged with nitrogen to replace any oxygen introduced into the system. The nitrogen flow rate was approximately 1 bubble per second. The mixture was purged with nitrogen while stirring for 1 hour. Using a plastic syringe, 4.75 g of a 25% sodium hydroxide aqueous solution was added to the contents of the flask over several minutes while stirring under nitrogen. The contents of the flask were then stirred under nitrogen for 30 minutes. Next, the contents of the addition funnel were added dropwise to the contents of the flask over several minutes while continuing to stir under nitrogen. After transferring the contents of the addition funnel to the contents of the flask, the mixture was stirred for 5 minutes. The contents of the flask were then heated using a heating mantle controlled by a J-KEM controller set to 70°C. The contents of the flask were heated and maintained at 70°C for 90 minutes. Next, the contents of the flask were cooled to room temperature while maintaining a positive nitrogen pressure inside the flask. When the contents of the flask reached room temperature, 2.50 g of acetic acid was added dropwise to the contents of the flask via a syringe, and the mixture was stirred for 5 minutes. The polymer was recovered by non-solvent precipitation of this aqueous solution using excess methanol. The precipitated cationic dextran polymer was then recovered by filtration through a Buchner funnel and dried overnight at 50°C under vacuum. The resulting branched-chain cationic dextran polymer was an off-white solid (29.8 g) with a volatile matter content of 3.80% and an ash content of 0.03% (as sodium chloride). The volatile matter and ash content were measured according to ASTM method D-2364.The Kjeldahl nitrogen content was measured using a Buchi KjelMaster K-375 automated analyzer and found to be 1.58% (corrected for volatile substances and ash), corresponding to a trimethylammonium substitution degree of 0.22.

[0061] Example S2: Synthesis of cationic dextran polymer A 500 mL four-necked round-bottom flask fitted with a rubber ceramic cap, nitrogen inlet, pressure equalization funnel, stirring paddle and motor, subsurface thermocouple connected to a J-KEM controller, and a Freidrich condenser connected to a mineral oil bubbler was used to add dextran (30.5 g, Aldrich product number D4876) and deionized water (141 g). A 70% aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (21.7 g, QUAB® 151, available from QUAB Chemicals) was added to the addition funnel. The contents of the flask were stirred until the dextran dissolved in the deionized water. While stirring the contents, the apparatus was purged with nitrogen to replace any oxygen introduced into the system. The nitrogen flow rate was approximately 1 bubble per second. The mixture was purged with nitrogen while stirring for 1 hour. Using a plastic syringe, 4.75 g of 25% sodium hydroxide aqueous solution was added to the contents of the flask over several minutes while stirring under nitrogen. The contents of the flask were then stirred under nitrogen for 30 minutes. Next, the contents of the addition funnel were added dropwise to the contents of the flask over several minutes while continuing to stir under nitrogen. After transferring the contents of the addition funnel to the contents of the flask, the mixture was stirred for 5 minutes. The contents of the flask were then heated using a heating mantle controlled by a J-KEM controller set to 70°C. The contents of the flask were heated and maintained at 70°C for 90 minutes. Next, the contents of the flask were cooled to room temperature while maintaining a positive nitrogen pressure inside the flask. When the contents of the flask reached room temperature, 2.5 g of glacial acetic acid was added dropwise to the contents of the flask via syringe. The contents of the flask were then stirred for 5 minutes. Next, excess methanol was added to the contents of the flask with vigorous stirring to precipitate the cationic dextran polymer from the solution. Next, the precipitated cationic dextran polymer was recovered by filtration through a Buchner funnel and dried overnight in a vacuum at 50°C.The resulting cationic dextran polymer was an off-white solid (29.8 g) with a volatile content of 3.80%, an ash content of 0.03% (as sodium chloride), and a Kjeldahl nitrogen content of 1.59%, corresponding to a degree of cationic substitution of 0.211.

[0062] Comparative Examples C1-C3 and Example 1: Body Wash Formulation In each of Comparative Examples C1-C3 and Example 1, a body wash formulation was prepared by combining the amounts of ingredients listed in Table 1.

[0063] [Table 1]

[0064] Performance testing The body wash formulations from Comparative Examples C1-C3 and Example 1 were adjusted to a pH of 6.5 using citric acid (25% in water). The final compositions were then applied to Vitro-Skin® high-gloss test substrates (available from IMS Inc.) using cotton-covered fingers. The treated substrates were then rinsed with deionized water, and the volume of oil on the substrates was evaluated. Eight replicated Vitro-Skin® high-gloss test substrate samples were prepared for each skin cleansing formulation. The following procedure was used: (a) a Vitro-Skin® high-gluten test substrate was cut into 4cm x 4cm pieces; (b) each test substrate was weighed; (c) 0.2 mL of skin cleansing compound sample was deposited onto the rough surface of the test substrate using a 1 mL HSW syringe (Henke Saas Wolf GmbH); (d) the deposited skin cleansing compound was then gently rubbed onto the substrate for approximately 15 seconds using a cotton-covered finger; (e) each test substrate was weighed again after treatment with the skin cleansing compound; (f) each treated substrate was left for 20 seconds before rinsing with water; and (g) each treated substrate was then rinsed with water at a water temperature of 32-38°C at a flow rate of 1 L / min. The rough surface (the surface to which the skin cleansing compound was applied) was subjected to the flow of rinse water for 15 seconds at a 45° angle, 5-10 cm from the faucet outlet, and (h) each rinsed substrate was placed in a clean tray with the treated surface facing upwards and left for 1 hour before proceeding with the sunflower oil deposition analysis.

[0065] Sunflower oil deposit analysis The deposition of sunflower oil on the Vitro-Skin® advanced test substrate was quantified by two-dimensional gas chromatography-mass spectrometry (2D-GC / MS).

[0066] Sample preparation: Each rinsed skin deposit sample (one 4cm x 4cm piece) was placed in a 1-ounce vial filled with 20 mL of hexane. The samples were then shaken in a shaker for approximately 1.5 hours. A portion of the liquid from each vial (5 mL) was then transferred to a separate 10 mL vial. 5 mL of 1 M KOH / MeOH solution was then added to each 10 mL vial. The 10 mL vials were then placed on a shaker for 1 hour, followed by 30 minutes of standing for sedimentation. The hexane layer was then filtered from each 10 mL vial into an autosampler vial using a 0.2 μm PTFE filter and analyzed by GC / MS.

[0067] 2D-GC / MS conditions: For the analysis of sunflower oil, an Agilent 7890B GC equipped with a flame ionization detector (FID) and a 5977A mass selective detector (MSD) was used. The GC conditions are described in Table 2 below.

[0068] [Table 2]

[0069] External calibration was applied to obtain the response coefficient of sunflower oil. A 1,000 mg / L stock solution was prepared by weighing 10 mg of sunflower oil into a 20 mL vial and adding 10 mL of hexane to the vial to achieve an accurate concentration of 1,000 mg / L. Calibration standard solutions at concentration levels 1, 2, 5, 10, 20, 50, 100, 200, and 500 mg / L were prepared by serial dilution from the stock solution using hexane as a diluent. 2 mL of each standard solution was combined with 200 μL of 1 M KOH / MeOH solution in a 5 mL vial. Each solution was shaken for 1 hour and then allowed to settle in a lab hood for 30 minutes until clear phase separation was obtained. Approximately 350 μL of the upper hexane layer was then transferred to a low-volume autosampler vial (with insert) for GC analysis.

[0070] The percentage of sunflower oil deposits was calculated using the following formula. Sediment % = (((W × weight of sunflower oil %) / v) / C) In the formula, % represents the weight percentage of sunflower oil derived from the coated formulation remaining on the Vitro-Skin® high-grade test substrate, C represents the concentration of sunflower oil in the extraction solvent in mg / mL as measured by 2D-GC / MS, W represents the weight in mg of the formulation coated on the Vitro-Skin® high-grade test substrate, % of sunflower oil represents the weight percentage of sunflower oil in the coated formulation, and v represents the volume in mL of hexane added to the coated formulation. The results are shown in Table 3.

[0071] [Table 3]

Claims

1. 1. A skin cleansing formulation comprising: a dermatologically acceptable vehicle; a dermatologically acceptable oil; a deposition aid polymer, wherein the deposition aid polymer is a cationic dextran polymer, including a dextran polymer functionalized with a quaternary ammonium group; A skin cleansing formulation, wherein the deposition aid polymer enhances deposition of the dermatologically acceptable oil from the skin cleansing formulation onto mammalian skin.

2. 10. The skin cleansing formulation of claim 1 further comprising a dermatologically acceptable personal care cleansing surfactant.

3. 3. The skin cleansing formulation of claim 2, wherein the dermatologically acceptable oil is selected from the group consisting of mineral oil, petrolatum, sunflower oil, soybean oil, coconut oil, silicone oil, and balm oil.

4. 4. A skin cleansing formulation according to claim 3, wherein the cationic dextran polymer has a Kjeldahl nitrogen content, or TKN, corrected for ash and volatiles, of 1.0 to 4.0% by weight.

5. the quaternary ammonium group is selected from the group consisting of a trialkylammonium moiety of formula (B) attached to the dextran polymer; 【Chemistry 1】 During the ceremony, 【Chemistry 2】 is the dextran polymer having pendant oxygens, X is a divalent linking group that attaches the trialkylammonium moiety to a pendant oxygen on the dextran polymer, and each R ２ are independently １～７ alkyl groups, R ３ is C １～２２ 5. The skin cleansing formulation of claim 4, wherein the alkyl group is selected from the group consisting of alkyl groups.

6. X is -CH ２ CH (OR ４ ) CH ２ - group, and R ４ is hydrogen and C １～４ 6. The skin cleansing formulation of claim 5, wherein the alkyl group is selected from the group consisting of alkyl groups.

7. Each R ５ 7. The skin cleansing formulation of claim 6, wherein is a methyl group.

8. 8. The skin cleansing formulation of claim 7, wherein the dermatologically acceptable personal care cleansing surfactant comprises a mixture of sodium laureth sulfate (SLES) and cocamidopropyl betaine, and the dermatologically acceptable oil is selected from the group consisting of mineral oil, petrolatum, sunflower oil, soybean oil, coconut oil, silicone oil, and balm oil.

9. 1. A method of making a skin cleansing formulation comprising: (a) providing a dermatologically acceptable vehicle; (b) providing a dermatologically acceptable oil; (c) selecting a cationic dextran polymer as a deposition aid for enhancing deposition of the dermatologically acceptable oil onto mammalian skin, wherein the cationic dextran polymer comprises a dextran polymer functionalized with a quaternary ammonium group; (d) combining said dermatologically acceptable vehicle, said dermatologically acceptable oil, and said cationic dextran polymer to form a skin cleansing formulation.

10. 1. A method for depositing a dermatologically acceptable oil onto mammalian skin, comprising: Providing a skin cleansing formulation according to claim 1; applying said skin cleansing formulation to said skin of a mammal.