Composition for oral cavity

Abstract

To provide a composition for oral cavity which ensures good stability of a composition while containing an oil-soluble component and ensures high adsorptivity of an oil-soluble component to tooth surfaces or gums in the oral cavity and oral cavity mucosa and has excellent persistence of the composition.SOLUTION: There is provided a composition for oral cavity which comprises the following components (A) to (C): (A) an unsaturated fatty acid having a hydrocarbon group having 10 or more and 22 or less carbon atoms, (B) one or two or more basic compounds selected from an organic amine, an alkali metal hydroxide, a carbonate, a bicarbonate and a sesquicarbonate and (C) one or two or more oil-soluble components selected from isopropyl methylphenol, triclosan, glycyrrhetinic acid, tocopherol, thymol and menthol, wherein the molar ratio ((A) / (C)) of the component (A) to the component (C) is 0.05 or more and 4 or less and the pH at 25°C is 8.0 or more and less than 9.6.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Oil-soluble components such as isopropyl methylphenol and glycyrrhetinic acid are known to have various effects on oral compositions, and have been incorporated into various oral compositions. In order to disperse or dissolve oil-soluble components that are poorly soluble in water in the composition, many of these compositions are used in combination with a nonionic surfactant. For example, Patent Document 1 discloses a liquid oral composition that uses an oil-soluble component such as triclosan in combination with cetylpyridinium chloride, a calcium salt, and a nonionic surfactant, and Patent Document 2 discloses a liquid oral composition in a foam-discharging container that uses an oil-soluble component such as β-glycyrrhetinic acid in combination with a nonionic surfactant and sodium alkyl sulfate. Patent Document 3 discloses an ethanol-free liquid oral composition that contains isopropylmethylphenol, propylene glycol and / or glycerin, a specific nonionic surfactant, and a water-soluble polymer compound. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2011-132169 A [Patent Document 2] JP 2018-123086 A [Patent Document 3] JP 2007-106728 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, even with the techniques described in the above patent documents, it is still difficult to increase the adsorption of oil-soluble components to tooth surfaces, gums, and oral mucosa in the oral cavity while also ensuring the stability of the composition, and there is ample room for improvement.

[0005] Therefore, the present invention relates to an oral composition which contains oil-soluble components while ensuring good stability of the composition, and which also ensures high adsorption of the oil-soluble components to the tooth surfaces, gums, and oral mucosa in the oral cavity, thereby providing excellent durability. [Means for solving the problem]

[0006] The present inventors have conducted extensive research to solve the above problems, and have found that, by containing a specific fatty acid, a specific basic compound, and a specific oil-soluble component in a specific molar ratio under a specific pH range, the fatty acid and the oil-soluble component form a vesicle-like aggregate in which the oil-soluble component is well embedded by the fatty acid and the basic compound. Furthermore, they have found that the formed vesicle-like aggregate can efficiently deliver the oil-soluble component to the tooth surface, gums, and oral mucosa while maintaining the stability of the composition well, and can effectively and sustainably adsorb the oil-soluble component at the delivery destination, and have arrived at the present invention.

[0007] That is, the present invention provides the following components (A) to (C): (A) Unsaturated fatty acid having a hydrocarbon group having 10 to 22 carbon atoms (B) One or more basic compounds selected from organic amines, alkali metal hydroxides, carbonates, bicarbonates, and sesquicarbonates. (C) one or more oil-soluble components selected from isopropylmethylphenol, triclosan, glycyrrhetinic acid, tocopherol, thymol, and menthol The present invention provides an oral composition comprising: a component (A) and a component (C) in a molar ratio ((A) / (C)) of 0.05 or more and 4 or less; and a pH at 25°C of 8.0 or more and less than 9.6. Effect of the Invention

[0008] According to the oral composition of the present invention, it is possible to ensure good stability of the composition while containing an oil-soluble component. In addition, it is possible to efficiently deliver and adsorb the oil-soluble component to the tooth surface, gums, and oral mucosa (hereinafter also referred to as "tooth surface, etc."), which are the destinations of delivery, and to effectively maintain the adsorption. Therefore, it is possible to maintain a good oral environment for a long period of time while fully enjoying the desired effects of the oil-soluble components. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The present invention will be described in detail below. In the present invention, "good stability of the composition" means that, when the composition for oral use of the present invention is a liquid composition for oral use such as a mouthwash or liquid dentifrice, the composition is highly transparent without the occurrence of precipitation, turbidity, or separation. Also, when the composition for oral use of the present invention is a dentifrice composition such as a toothpaste or powder dentifrice, the composition means that the components are well dispersed or dissolved without separation, resulting in high uniformity.

[0010] The oral composition of the present invention contains, as component (A), an unsaturated fatty acid having a hydrocarbon group with 10 to 22 carbon atoms. The number of carbon atoms in the hydrocarbon group of the fatty acid of component (A) is 10 or more, preferably 12 or more, more preferably 14 or more, even more preferably 18 or more, and 22 or less, preferably 20 or less, from the viewpoint of increasing the adsorption amount and the duration of the adsorption of the oil-soluble component of component (C) described later to the tooth surface, and from the viewpoint of ensuring good stability of the composition. Examples of such a hydrocarbon group include a straight chain hydrocarbon group and a branched chain hydrocarbon group, and specifically, for example, one or more types selected from myristoleic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, etc. Among them, from the viewpoint of increasing the amount of fluoride ion adsorbed to the tooth surface and the duration of the adsorption, one or more types selected from palmitoleic acid, oleic acid, and linoleic acid are preferable, and oleic acid is more preferable.

[0011] The content of component (A) in the oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.04% by mass or more, and even more preferably 0.05% by mass or more, from the viewpoint of efficiently and continuously delivering and adsorbing component (C) to the tooth surface while maintaining excellent stability. The content of component (A) in the oral composition of the present invention is preferably 0.5% by mass or less, more preferably 0.4% by mass or less, even more preferably 0.2% by mass or less, and even more preferably 0.1% by mass or less, from the viewpoint of ensuring good stability of the composition. The content of component (A) in the oral composition of the present invention is preferably 0.005% by mass or more and 0.5% by mass or less, more preferably 0.02 to 0.4% by mass, even more preferably 0.04 to 0.2% by mass, and even more preferably 0.05 to 0.1% by mass.

[0012] From the same viewpoint, the content of component (A) in the oral composition of the present invention is preferably 0.17 to 18 mmol / L, more preferably 0.70 to 14 mmol / L, even more preferably 1.4 to 7.0 mmol / L, still more preferably 1.6 to 3.5 mmol / L, and even more preferably 1.8 to 2.145 mmol / L.

[0013] The oral composition of the present invention contains, as component (B), one or more basic compounds selected from organic amines, alkali metal hydroxides, carbonates, bicarbonates, and sesquicarbonates. By containing such component (B), it is possible to ensure good stability of the composition, and it is considered that the composition forms a vesicle-like association with component (A) while encapsulating component (C) described below. This is considered to promote efficient delivery and adsorption of component (C) to the tooth surface, etc., and to realize highly sustained adsorption.

[0014] Specific examples of organic amines include one or more basic amino acids selected from arginine, lysine, and histidine; and one or more alkanolamine compounds selected from monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0015] Specific examples of the alkali metal hydroxide include one or more selected from sodium hydroxide, potassium hydroxide, calcium hydroxide, and lithium hydroxide.

[0016] Specific examples of carbonates, bicarbonates, and sesquicarbonates include one or more selected from sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, and sodium sesquicarbonate.

[0017] Among these, component (B) is preferably one or more basic compounds selected from alkali metal hydroxides and basic amino acids, from the viewpoint of effectively forming a vesicle-like aggregate together with component (A) while embedding component (C) to efficiently deliver the component to the tooth surface, etc., and from the viewpoint of ensuring good stability of the composition, and is more preferably potassium hydroxide, arginine, or lysine.

[0018] The content of component (B) in the oral composition of the present invention is preferably 0.001% by mass or more, more preferably 0.006% by mass or more, and even more preferably 0.01% by mass or more, from the viewpoint of efficiently forming a vesicle-like aggregate with component (A) and ensuring good stability of the composition. Also, the content of component (B) in the oral composition of the present invention is preferably 0.4% by mass or less, more preferably 0.2% by mass or less, even more preferably 0.08% by mass or less, even more preferably 0.03% by mass or less, and even more preferably 0.02% by mass or less, from the viewpoint of effectively maintaining the adsorption of component (C) to the tooth surface, etc. The content of component (B) in the oral composition of the present invention is preferably 0.001 mass% or more and 0.4 mass% or less, more preferably 0.006 to 0.2 mass%, even more preferably 0.01 to 0.08 mass%, still more preferably 0.01 to 0.03 mass%, and even more preferably 0.01 to 0.02 mass%.

[0019] From the same viewpoint, the content of component (B) in the oral composition of the present invention is preferably 0.1 to 20 mmol / L, more preferably 0.5 to 15 mmol / L, even more preferably 1 to 10 mmol / L, still more preferably 1.5 to 4.5 mmol / L, and even more preferably 2.3 to 2.5 mmol / L.

[0020] The molar ratio ((B) / (A)) of the content of component (B) to the content of component (A) is preferably 0.2 or more, more preferably 0.4 or more, even more preferably 0.6 or more, still more preferably 0.8 or more, and preferably 5 or less, more preferably 3 or less, still more preferably 2 or less, and still more preferably 1.5 or less, from the viewpoint of efficiently forming a vesicle-like aggregate with component (A) and ensuring good stability of the composition while promoting good delivery and adsorption of component (C) to the tooth surface or the like. The molar ratio ((B) / (A)) of the content of component (B) to the content of component (A) is preferably 0.2 to 5, more preferably 0.4 to 3, still more preferably 0.6 to 2, and still more preferably 0.8 to 1.5.

[0021] The oral composition of the present invention contains, as component (C), one or more oil-soluble components selected from isopropylmethylphenol (c1), triclosan (c2), glycyrrhetinic acid (c3), tocopherol (c4), thymol (c5), and menthol (c6). Each of these components (C) exerts a unique action in the oral cavity.

[0022] The content of component (C) in the oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.015% by mass or more, and even more preferably 0.02% by mass or more in total, from the viewpoint of efficient and sustained adsorption on the tooth surface and the like and effective exertion of the desired action. Also, the content of component (C) in the oral composition of the present invention is preferably 1.0% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and even more preferably 0.2% by mass or less, from the viewpoint of ensuring good stability of the composition. And, the content of component (C) in the oral composition of the present invention is preferably 0.005 to 1.0% by mass, more preferably 0.01 to 0.5% by mass, even more preferably 0.015 to 0.3% by mass, and even more preferably 0.02 to 0.2% by mass.

[0023] From the same viewpoint, the content of component (C) in the oral composition of the present invention is preferably 0.1 to 65 mmol / L in total, more preferably 0.2 to 30 mmol / L, even more preferably 0.3 to 20 mmol / L, still more preferably 0.4 to 13 mmol / L, and even more preferably 1 to 7.5 mmol / L.

[0024] When component (C) contains isopropylmethylphenol (c1), the content of component (c1) in the oral cavity composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, preferably 0.5% by mass or less, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less. The content of component (c1) in the oral cavity composition of the present invention is preferably 0.005 to 0.5% by mass, more preferably 0.01 to 0.2% by mass, even more preferably 0.02 to 0.1% by mass.

[0025] When component (C) contains triclosan (c2), the content of component (c2) in the oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, and preferably 0.5% by mass or less, more preferably 0.2% by mass or less, and even more preferably 0.15% by mass or less. The content of component (c2) in the oral composition of the present invention is preferably 0.005 to 0.5% by mass, more preferably 0.01 to 0.2% by mass, and even more preferably 0.02 to 0.15% by mass.

[0026] When component (C) contains glycyrrhetinic acid (c3), the content of component (c3) in the oral cavity composition of the present invention is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.05% by mass or more, preferably 0.5% by mass or less, more preferably 0.45% by mass or less, and even more preferably 0.3% by mass or less. The content of component (c3) in the oral cavity composition of the present invention is preferably 0.01 to 0.5% by mass, more preferably 0.02 to 0.45% by mass, and even more preferably 0.05 to 0.3% by mass.

[0027] When component (C) contains tocopherol (c4), the content of component (c4) in the oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.015% by mass or more, preferably 0.1% by mass or less, more preferably 0.05% by mass or less, even more preferably 0.02% by mass or less. The content of component (c4) in the oral composition of the present invention is preferably 0.005 to 0.1% by mass, more preferably 0.01 to 0.05% by mass, even more preferably 0.015 to 0.02% by mass.

[0028] When component (C) contains thymol (c5), the content of component (c5) in the oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, preferably 0.5% by mass or less, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less. The content of component (c5) in the oral composition of the present invention is preferably 0.005-0.5% by mass, more preferably 0.01-0.2% by mass, even more preferably 0.02-0.1% by mass.

[0029] When component (C) contains menthol (c6), the content of component (c6) in the oral cavity composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, preferably 0.5% by mass or less, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less. The content of component (c6) in the oral cavity composition of the present invention is preferably 0.005 to 0.5% by mass, more preferably 0.01 to 0.2% by mass, even more preferably 0.02 to 0.1% by mass.

[0030] The molar ratio of component (A) to component (C) ((A) / (C)) is 0.05 or more, preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.4 or more, and 4 or less, preferably 2 or less, more preferably 1.5 or less, and even more preferably 1 or less, from the viewpoint of ensuring good stability of the composition while efficiently and sustainably adsorbing component (C) to the tooth surface or the like to effectively exert the desired action. The molar ratio of component (A) to component (C) ((A) / (C)) is 0.05 or more and 4 or less, preferably 0.1 to 2, more preferably 0.2 to 1.5, and even more preferably 0.4 to 1.

[0031] When component (C) contains isopropylmethylphenol (c1), the molar ratio of component (A) to component (c1) ((A) / (c1)) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.2 or more, and preferably 4 or less, more preferably 2 or less, even more preferably 1.5 or less.

[0032] When component (C) contains triclosan (c2), the molar ratio of component (A) to component (c2) ((A) / (c2)) is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.4 or more, and preferably 4 or less, more preferably 3 or less, even more preferably 2.5 or less.

[0033] When component (C) contains glycyrrhetinic acid (c3), the molar ratio of component (A) to component (c3) ((A) / (c3)) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.2 or more, and is preferably 4 or less, more preferably 3 or less, even more preferably 2 or less.

[0034] When component (C) contains tocopherol (c4), the molar ratio of component (A) to component (c4) ((A) / (c4)) is preferably 0.2 or more, more preferably 0.3 or more, even more preferably 0.4 or more, and is preferably 4 or less, more preferably 3 or less, even more preferably 2 or less.

[0035] When component (C) contains thymol (c5), the molar ratio of component (A) to component (c5) ((A) / (c5)) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.2 or more, and preferably 4 or less, more preferably 2 or less, even more preferably 1.5 or less.

[0036] When component (C) contains menthol (c6), the molar ratio of component (A) to component (c6) ((A) / (c6)) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.2 or more, and is preferably 4 or less, more preferably 2 or less, even more preferably 1.5 or less.

[0037] The oral composition of the present invention contains water. In the present invention, water means the total water contained in the oral composition, including not only purified water and the like contained in the oral composition, but also the water contained in each of the components contained. By containing such water, each of the components contained therein can be well dissolved or dispersed, and the desired effect can be fully exerted.

[0038] Specifically, when the oral composition of the present invention is a liquid oral composition such as a mouthwash or liquid dentifrice, the content of the water in the oral composition of the present invention is preferably 50% by mass or more, more preferably 70% by mass or more, even more preferably 80% by mass or more, preferably 99.7% by mass or less, more preferably 99.5% by mass or less, and even more preferably 99.4% by mass or less. When the oral composition of the present invention is a liquid oral composition such as a mouthwash or liquid dentifrice, the content of the water in the oral composition of the present invention is preferably 50 to 99.8% by mass, more preferably 70 to 99.5% by mass, and even more preferably 80 to 99.4% by mass. Furthermore, when the oral composition of the present invention is a dentifrice composition such as a toothpaste or a dentifrice powder, the content of the water in the oral composition of the present invention is preferably 5% by mass or more, more preferably 10% by mass or more, and preferably 70% by mass or less, more preferably 65% ​​by mass or less. Also, when the oral composition of the present invention is a dentifrice composition such as a toothpaste or a dentifrice powder, the content of the water is preferably 5 to 70% by mass, more preferably 10 to 65% by mass.

[0039] When the oral composition of the present invention is a dentifrice composition such as a toothpaste or a tooth powder, the water content can be calculated from the amount of water contained in the composition and the amount of water contained in the components, but the water content of the dentifrice composition can be measured, for example, with a Karl Fischer moisture meter. As the Karl Fischer moisture meter, for example, a trace water meter (manufactured by Hiranuma Sangyo Co., Ltd.) can be used. With this device, 5 g of the dentifrice composition is suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension is taken to measure the water content.

[0040] From the viewpoint of efficient and sustained delivery and adsorption of component (C) to tooth surfaces and the like, it is preferable that the oral composition of the present invention limit the content of nonionic surfactants. Specific examples of nonionic surfactants include polyoxyethylene alkyl (or alkenyl) ethers such as polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, monocetyl glyceryl ether, polyoxyethylene stearyl ether, and polyoxyethylene oleyl ether; polyoxyethylene derivatives such as polyoxyalkyl allyl ether, polyoxyethylene distyrenated phenyl ether, polyoxyethylene hydrogenated castor oil, and polyoxyethylene lanolin; sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, and sorbitan monostearate; polyoxyethylene olefins such as sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, and sorbitan monostearate; Examples of the fatty acid ester include polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, and polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitan tetraoleate; polyethylene glycol fatty acid esters such as polyethylene glycol monolaurate and polyethylene glycol monooleate; alkyl glyceryl ethers such as isostearyl glyceryl ether; glycerin fatty acid esters such as glyceryl monobehenate; and alkyl glycosides such as decyl glucoside and lauryl glucoside. Preferred nonionic surfactants include one or more selected from polyoxyethylene monoalkyl ethers, polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, and polyglycerin fatty acid esters.

[0041] The content of nonionic surfactant in the oral composition of the present invention is preferably 0.4 mass% or less, preferably 0.15 mass% or less, more preferably 0.08 mass% or less, and even more preferably 0.05 mass% or less, or it is preferable that the oral composition of the present invention does not contain a nonionic surfactant.

[0042] It is preferable that the oral cavity composition of the present invention contains limited amounts of one or more surfactants selected from anionic surfactants other than component (A) and amphoteric surfactants. Specific examples of the anionic surfactant other than component (A) include one or more selected from the group consisting of alkyl sulfate esters or salts thereof, such as lauryl sulfate or its salts, myristyl sulfate or its salts, palmityl sulfate or its salts, stearyl sulfate or its salts, octyl sulfate or its salts, and capryl sulfate or its salts; alkyl sulfonic acids or salts thereof, such as alkylbenzene sulfonic acids or their salts, α-olefin sulfonic acids or their salts, and hydroxyalkanesulfonic acids or their salts; acyl amino acids or salts thereof, such as acyl glutamic acids or their salts, and acyl sarcosines or their salts; N-methyl long-chain acyltaurines or their salts, such as lauryl methyl taurine or its salts; alkyl phosphoric acids or salts thereof, such as monoalkyl phosphoric acids or their salts; higher fatty acid sulfonated monoglycerides or their salts, fatty acid esters of isethionic acid or their salts; and polyoxyethylene monoalkyl phosphoric acids or their salts.

[0043] Specific examples of amphoteric surfactants include one or more selected from alkylamine oxides; acetate betaines such as lauryl dimethylaminoacetate betaine; imidazolinium betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amidoalkyl betaines such as coconut oil fatty acid amidopropyl betaine; and long-chain alkyl imidazoline betaine salts such as N-alkyl-1-hydroxyethyl imidazoline betaine sodium.

[0044] The content of one or more surfactants selected from anionic surfactants other than component (A) and amphoteric surfactants in the oral composition of the present invention is preferably less than 0.5 mass%, more preferably less than 0.25 mass%, in total. Alternatively, it is preferable that the oral composition of the present invention does not contain one or more surfactants selected from anionic surfactants other than component (A) and amphoteric surfactants.

[0045] The oral composition of the present invention may contain, in addition to the above-mentioned components, appropriate components such as pH adjusters, bactericides, sugar alcohols, humectants, thickeners, abrasives, preservatives, medicinal ingredients other than component (C) and other active ingredients, fragrances, pigments, etc., within the scope of not impairing the effects of the present invention.

[0046] The pH of the oral composition of the present invention at 25°C is 8.0 or more, preferably 8.2 or more, more preferably 8.5 or more, even more preferably 8.8 or more, even more preferably 9.0 or more, less than 9.6, preferably 9.5 or less, more preferably 9.4 or less, even more preferably 9.3 or less, and even more preferably 9.2 or less, from the viewpoint of increasing the adsorption of component (C) to the tooth surface and the like and the duration thereof, and from the viewpoint of ensuring good stability of the composition. The pH of the oral composition of the present invention at 25°C is 8.0 or more and less than 9.6, preferably 8.2 to 9.5, more preferably 8.5 to 9.4, even more preferably 8.8 to 9.3, and even more preferably 9.0 to 9.2. The pH of the oral composition of the present invention is a value measured at 25°C using a pH electrode. When the oral composition of the present invention is a liquid oral composition, it means a value measured without diluting the composition. When the oral composition of the present invention is a dentifrice composition, it means a value measured after adjusting the composition to a 10% by mass aqueous solution with purified water consisting of ion-exchanged water or distilled water. EXAMPLES

[0047] The present invention will now be described in detail with reference to the following examples. In the tables, the content of each component is expressed as mass % unless otherwise specified.

[0048] [Examples 1 to 15, Comparative Examples 1 to 7] Oral compositions were prepared according to the formulations shown in Table 1. Using each of the obtained oral compositions, measurements and evaluations were carried out according to the following methods. The results are shown in Table 1.

[0049] <pH Measurement> The pH (25° C.) of 20 ml of each of the obtained oral compositions was measured using a pH / ION METER F53 (manufactured by HORIBA).

[0050] <Stability evaluation> Each of the obtained oral compositions was stored in an incubator at 25° C. for 30 minutes, after which the appearance was visually inspected and the stability of the composition was evaluated according to the following criteria. A: Uniform and transparent (not cloudy, no precipitate or sediment was observed) B: Generally uniform and slightly cloudy C: Cloudy and translucent D: Separation or precipitation was observed.

[0051] <<Measurement of the adsorption amount of component (C)>> The HPLC measurement conditions were selected depending on the type of component (C), and the adsorption amount was measured according to the following method. Immediately after preparing each oral composition, the amount of adsorption was measured as the "initial adsorption amount," and then the oral composition remaining in the oral cavity was rinsed with water, after which the amount of adsorption was measured again as the "adsorption amount after rinsing."

[0052] A cylindrical tube (cross-sectional area 7.07 × 10 -4 m 2) was placed with one open end surface in close contact with the surface of the silicone sheet. Next, 1.0 g of each oral composition was poured into the cylindrical tube from the other open end of the cylindrical tube so that the contact area between the sample and the silicone sheet was the same as the inner cross-sectional area of ​​the cylindrical tube, and applied to the surface of the silicone sheet inside the cylindrical tube surrounded by the circumferential surface of the cylindrical tube, and the composition was left in contact with the silicone sheet for 2 minutes. Then, 1.5 mL of extraction solution (mobile phase shown below) was applied for 30 seconds to recover component (C), and the quantitative determination (μmol / m) of component (C) was performed by high performance liquid chromatography (HPLC) according to the following measurement conditions. 2 ) was performed and this was taken as the "initial amount of adsorption." Furthermore, a silicone sheet that had been contacted with the composition under the same conditions was immersed in 50 mL of ion-exchanged water in a 50 mL beaker for 30 seconds, then removed from the beaker and 1.5 mL of extraction solution (mobile phase shown below) was applied for 30 seconds to recover component (C). Component (C) was then quantified (μmol / m) by high performance liquid chromatography (HPLC) or gas chromatography (GC) according to the measurement conditions below. 2 ) and this was recorded as the "amount adsorbed after rinsing."

[0053] -HPLC measurement conditions for isopropyl methylphenol Equipment: HPLC Prominence-i (Shimadzu Corporation) Detector: Ultraviolet spectrophotometer (measurement wavelength: 279 nm) Column: L-column ODS (4.6 x 100 mm, 5 μm) (manufactured by Chemicals Evaluation and Research Institute, Japan) Column temperature: 40℃ Mobile phase: Methanol / water mixture (3:2) + 0.1 w / v% phosphoric acid Flow rate: 1.0mL / min

[0054] · HPLC measurement conditions for triclosan Equipment: HPLC Prominence-i (Shimadzu Corporation) Detector: Ultraviolet absorption spectrophotometry (measurement wavelength: 254 nm) Column: LiChroCART 125-4 Superspher 100 RP-18 (Merck) Column temperature: 40℃ Mobile phase: Methanol / water mixture (70:30) + 0.1 w / v% phosphoric acid Flow rate: 1.0mL / min

[0055] · HPLC measurement conditions for β-glycyrrhetinic acid Equipment: HPLC Prominence-i (Shimadzu Corporation) Detector: Ultraviolet absorption photometer (measurement wavelength: 250 nm) Column: L-column ODS (4.6 x 100 mm, 5 μm) (manufactured by Chemicals Evaluation and Research Institute, Japan) Column temperature: 40℃ Mobile phase: Methanol / water mixture (3:1) + 0.1 w / v% phosphoric acid Flow rate: 1.0mL / min

[0056] ·HPLC measurement conditions for tocopherol Equipment: HPLC Prominence-i (Shimadzu Corporation) Detector: Ultraviolet spectrophotometer (measurement wavelength: 280 nm) Column: L-column ODS (4.6 x 100 mm, 5 μm) (manufactured by Chemicals Evaluation and Research Institute, Japan) Column temperature: 40℃ Mobile phase: Methanol / water mixture (49:1) + 0.1 w / v% phosphoric acid Flow rate: 1.0mL / min

[0057] -GC measurement conditions for thymol Equipment: Gas chromatograph 6890N (Agilent Technologies) Column: DB-1MS-UI (inner diameter 0.25 mm, length 60 m, film thickness 250 μm) (Agilent Technologies) Column temperature: 100°C (1 min) → [5°C / min temperature increase] → 150°C (1 min) → [30°C / min temperature increase] → 260°C (5 min) Inlet temperature: 250℃ Carrier gas: He 1.0mL / min

[0058] - GC measurement conditions for menthol Equipment: Gas chromatograph 6890N (Agilent Technologies) Column: DB-1MS-UI (inner diameter 0.25 mm, length 60 m, film thickness 250 μm) (Agilent Technologies) Column temperature: 100°C (1 min) → [5°C / min temperature increase] → 150°C (1 min) → [30°C / min temperature increase] → 260°C (5 min) Inlet temperature: 250℃ Carrier gas: He 1.0mL / min

[0059] Evaluation of the durability of adsorption The percentage (%) of the "amount of adsorption after rinsing (mass%)" based on the "initial amount of adsorption (mass%)" was calculated and used as an index for evaluating the durability of adsorption. The larger this value is, the longer the duration of adsorption of component (C) to the tooth surface, etc. is.

[0060] [Table 1]

[0061] Table 2 shows examples of formulations of the oral composition of the present invention.

[0062] [Table 2]

Claims

1. The following components (A) to (C): (A) Unsaturated fatty acid having a hydrocarbon group having 10 to 22 carbon atoms (B) one or more basic compounds selected from organic amines, alkali metal hydroxides, carbonates, bicarbonates, and sesquicarbonates (C) one or more oil-soluble components selected from isopropylmethylphenol, triclosan, glycyrrhetinic acid, tocopherol, thymol, and menthol wherein the molar ratio of component (A) to component (C) ((A) / (C)) is 0.05 or more and 4 or less, and the pH at 25°C is 8.0 or more and less than 9.

6.

2. 2. The oral composition according to claim 1, wherein the content of component (A) is 0.005% by mass or more and 0.5% by mass or less.

3. 3. The oral composition according to claim 1, wherein component (B) is one or more basic compounds selected from the group consisting of alkali metal hydroxides and basic amino acids.

4. 3. The oral composition according to claim 1, wherein the content of a nonionic surfactant is 0.4 mass% or less, or the composition is free of a nonionic surfactant.

5. 3. The oral composition according to claim 1, wherein the molar ratio ((B) / (A)) of the content of component (B) to the content of component (A) is 0.2 or more and 5.0 or less.