Oil-in-water type emulsion composition

Abstract

To provide an oil-in-water type emulsion composition which suppresses crystallization even after a long period of time after application, makes the skin smooth and causes no squeaking after application, provides a moist feeling during application and has excellent skin penetration properties.SOLUTION: There is provided an oil-in-water type emulsion composition which comprises the following components (A), (B), (C), (D) and (E): (A) one or more selected from cholesterol and phytosterol, (B) an oil agent which is solid at 25°C other than the component (A), (C) a trivalent or higher polyhydric alcohol, (D) one or more selected from a polyoxyethylene phytosterol having an average addition molar number of the oxyethylene group of 2 to 18 and a polyoxyethylene cholesterol and (E) water.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oil-in-water emulsion composition. [Background technology]

[0002] Emulsion compositions containing solid or semi-solid oils such as cholesterol or ceramide are expected to have a high moisturizing effect, but have problems with stability such as crystal precipitation and separation, and compositions with improvements on these issues are being studied. For example, Patent Document 1 describes that an emulsion cosmetic containing ceramide, meadowfoam estolide, cholesterol or phytosterol, and a nonionic surfactant can stably contain the ceramide without crystallizing it. Patent Document 2 describes that a cosmetic composition containing ceramides and / or phytosterol, a nonionic surfactant with an HLB of 4 to 8, polyoxyethylene hydrogenated castor oil with an HLB of 13 to 16.5, water, dipropylene glycol, etc., is stable and does not cause precipitation of ceramide crystals. Patent Document 3 describes that a vesicle composition containing ceramides, phytosterol, sodium dilauroyl glutamate lysine, monostearyl glycerin ether, dipropylene glycol and / or tripropylene glycol, and water is excellent in terms of stable formulation of ceramide, without crystal precipitation even when it contains a large amount of ceramide. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2016-108243 A [Patent Document 2] Patent Publication No. 2021-113155 [Patent Document 3] Patent Publication No. 2021-50200 Summary of the Invention [Problem to be solved by the invention]

[0004] However, although conventional emulsion compositions containing high-melting point solid fats have improved stability, such as preventing crystal precipitation and separation after production, they have problems with the feel when used, such as crystallization after application and poor skin smoothness after application. [Means for solving the problem]

[0005] The present inventors have found that by using a combination of a trihydric or higher polyhydric alcohol and a specific polyoxyethylene phytosterol or polyoxyethylene cholesterol together with cholesterol or a solid oil, crystallization of the solid oil such as cholesterol is suppressed even long hours after application, and an oil-in-water emulsion composition can be obtained which leaves the skin smooth and free of squeaking after application, provides a moist feeling upon application, and has excellent skin permeability.

[0006] The present invention comprises the following components (A), (B), (C), (D) and (E): (A) one or more selected from cholesterol and phytosterol, (B) an oil agent other than component (A) that is solid at 25°C; (C) trihydric or higher polyhydric alcohol, (D) one or more selected from polyoxyethylene phytosterols and polyoxyethylene cholesterols having an average number of moles of oxyethylene groups added of 2 to 18, (E)Water The present invention relates to an oil-in-water emulsion composition comprising: Effect of the Invention

[0007] The oil-in-water emulsion composition of the present invention inhibits crystallization of solid oils such as cholesterol even long after application, leaves the skin smooth and free of squeaking after application, provides a moist feeling upon application, and has excellent skin permeability. [Brief description of the drawings]

[0008] [Figure 1]FIG. 1 shows the results of skin permeability evaluation using an artificial membrane in an example. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The component (A) used in the present invention is one or more members selected from cholesterol and phytosterol. The content of component (A) is preferably 0.05 to 4 mass% of the total composition, more preferably 0.15 to 3.5 mass%, and even more preferably 0.5 to 2.5 mass%, from the viewpoints of suppressing crystallization of the solid oil even long after application, improving skin smoothness after application, suppressing the squeaky feeling of the skin after application, improving the moist feeling during application, and improving the skin permeability of the active ingredient after application.

[0010] Component (B) is an oil agent other than component (A) that is solid at 25°C. Here, solid at 25°C includes semi-solid and means that the viscosity at 25°C is greater than 10,000 mPa s. Viscosity is measured using a B-type viscometer (VISCOMETER TVB-10, manufactured by Toki Sangyo Co., Ltd.) with rotor No. 4, 12 rpm, and 1 minute.

[0011] The oil of component (B) is not limited as long as it is one that is normally used in cosmetics, and examples of the oil that can be used include fatty acids, fatty alcohols, cholesterol derivatives, phytosterol derivatives, ceramides, phospholipids, and hydrocarbon oils. More specifically, examples of fatty acids include fatty acids having 12 to 22 carbon atoms, such as lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid. From the viewpoint of improving the moist feeling during application, it is preferable to include one or more selected from myristic acid, palmitic acid, stearic acid, and behenic acid, more preferably to include one or more selected from stearic acid and behenic acid, and even more preferably to include stearic acid.

[0012] Examples of the fatty alcohol include fatty alcohols having 12 to 30 carbon atoms, such as cetyl alcohol, stearyl alcohol, behenyl alcohol, batyl alcohol, and chimyl alcohol. From the viewpoint of improving the moist feeling during application, it is preferable to include one or more types selected from cetyl alcohol, stearyl alcohol, and batyl alcohol, and it is more preferable to include one or more types selected from cetyl alcohol and stearyl alcohol.

[0013] Examples of cholesterol derivatives include cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl macadamiate, di(cholesteryl-behenyl-octyldodecyl) N-lauroyl-L-glutamate, and the like. From the viewpoint of improving the moist feeling during application, it is preferable to include one or more selected from cholesteryl isostearate, cholesteryl macadamiate, and di(cholesteryl-behenyl-octyldodecyl) N-lauroyl-L-glutamate, more preferably to include one or more selected from cholesteryl isostearate and cholesteryl macadamiate, and even more preferably to include cholesteryl isostearate.

[0014] Examples of phytosterol derivatives include di(phytosteryl, behenyl, 2-octyldodecyl) N-lauroyl-L-glutamate, phytosteryl isostearate, phytosteryl oleate, etc., and from the viewpoint of improving the moist feeling during application, it is preferable to include one or more selected from di(phytosteryl, behenyl, 2-octyldodecyl) N-lauroyl-L-glutamate and phytosteryl isostearate, and it is more preferable to include di(phytosteryl, behenyl, 2-octyldodecyl) N-lauroyl-L-glutamate.

[0015] Examples of ceramides include natural ceramides such as ceramides 1, 2, 3, 4, 5, 6, and 7, sphingosine derivatives such as phytosphingosine, and ceramide-like structural substances described in JP-A-62-228048, JP-A-63-216812, JP-A-63-227513, JP-A-64-29347, JP-A-64-31752, and JP-A-8-319263. Specific examples of ceramide-like structural substances that can reduce stickiness on the skin after application and improve moisturizing effects include compounds represented by the following general formulas (1) and (2).

[0016] [ka]

[0017] [In the formula, R 1b is a hydrocarbon group having 10 to 26 carbon atoms, R 2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X is -(CH2) n - (where n is an integer from 2 to 6).

[0018] [ka]

[0019] (In the formula, R 1 and R 2 are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, provided that R 3 When is a single bond, R 4 is a hydrogen atom.)

[0020] In the general formulas (1) and (2), the hydrocarbon group is preferably an alkyl group or an alkenyl group. An example of a compound of general formula (1) is N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and an example of a compound of general formula (2) is long-chain dibasic acid bis-3-methoxypropylamide.

[0021] From the viewpoint of improving the moist feeling during application and improving the moisturizing effect, the ceramides preferably include one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formulas (1) and (2), more preferably one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formula (1), even more preferably one or more types selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and even more preferably N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide.

[0022] From the viewpoint of improving the moist feeling during application and improving the moisturizing effect, the phospholipid preferably has a phosphatidylcholine content of 60% by mass or more, more preferably 64% by mass or more, even more preferably 68% by mass or more, and even more preferably 70% by mass or more. Examples of phospholipid components other than phosphatidylcholine include phosphatidic acid, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylglycerol.

[0023] The phospholipid may be a natural product extracted and purified from animals and plants, or may be chemically synthesized, or may be processed by hydrogenation, hydroxylation, etc. As the natural product, from the viewpoint of improving the moist feeling during application and improving the moisturizing effect, phospholipids that are extracts from soybeans or egg yolks or purified products thereof are preferred, and phospholipids that have been hydrogenated or hydroxylated are more preferred. Specifically, one or more selected from hydrogenated soybean lecithin and hydrogenated egg yolk lecithin are preferred, and hydrogenated soybean lecithin is more preferred. Examples of the hydrocarbon oil include petrolatum and microcrystalline wax.

[0024] From the viewpoint of improving the moist feeling during application and improving the moisturizing effect, component (B) preferably contains one or more selected from fatty acids, fatty alcohols, cholesterol derivatives, phytosterol derivatives, ceramides, and phospholipids, more preferably contains one or more selected from cholesterol derivatives, phytosterol derivatives, ceramides, and phospholipids, even more preferably contains one or more selected from ceramides and phospholipids, and even more preferably contains ceramides.

[0025] Component (B) may be used alone or in combination with other components, and from the viewpoints of improving the smoothness of the skin after application, suppressing the squeaky feeling of the skin after application, improving the moist feeling during application, and improving the skin permeability of the active ingredient after application, the content is preferably 0.05 to 4 mass%, more preferably 0.15 to 3.5 mass%, and even more preferably 0.5 to 2.5 mass% of the total composition.

[0026] The trihydric or higher polyhydric alcohol of component (C) is a compound having three or more hydroxyl groups in the molecule, and may be any of those commonly used in cosmetic preparations. Examples of trihydric alcohols include glycerin and trimethylolpropane. Examples of tetrahydric alcohols include diglycerin and erythritol. Examples of polyhydric alcohols having a valence of five or more include polyglycerins such as triglycerin, sugars and sugar alcohols such as glucose, maltose, maltose, sucrose, xylitol, sorbitol, malbitol, polyoxyethylene methyl glucoside, polyoxyethylene ethyl glucoside, and polyoxyethylene propylene glucoside.

[0027] As the polyhydric alcohol of component (C), from the viewpoints of improving the smoothness of the skin after application, suppressing the squeaky feeling of the skin after application, improving the moist feeling during application, and improving the skin permeability of the active ingredient after application, glycerin, diglycerin, and sorbitol are preferred, and glycerin and sorbitol are more preferred.

[0028] Component (C) may be used alone or in combination with other components, and from the viewpoints of inhibiting crystallization of the solid oil even long after application, improving skin smoothness after application, inhibiting squeaky feeling on the skin after application, improving moist feeling during application, and improving skin permeability of the active ingredient after application, the content is preferably 0.5 to 25 mass% of the total composition, more preferably 1.5 to 22 mass%, even more preferably 3 to 18 mass%, and even more preferably 5 to 14 mass%.

[0029] The component (D) is one or more members selected from polyoxyethylene phytosterols and polyoxyethylene cholesterols having an average added mole number of 2 to 18 oxyethylene groups. The average number of moles of oxyethylene groups added to the polyoxyethylene phytosterol is preferably 3 to 12, and more preferably 4 to 8, from the viewpoint of suppressing crystallization of the solid oil even after a long time has passed since application. Examples of polyoxyethylene phytosterols include PEG-5 phytosterols having an average number of moles of oxyethylene groups added of 5, and PEG-10 phytosterols having an average number of moles of oxyethylene groups added of 10. As the polyoxyethylene phytosterol, commercially available products can be used, for example, NIKKOL BPS-5, which is a PEG-5 phytosterol, and NIKKOL BPS-10, which is a PEG-10 phytosterol, both manufactured by Nikko Chemicals Co., Ltd.

[0030] The polyoxyethylene cholesterol preferably has an average added mole number of oxyethylene groups constituting the polyoxyethylene cholesterol of 3-15, more preferably 4-10. Examples of polyoxyethylene cholesterol include cholesterol-5, which has an average number of moles of oxyethylene groups added of 5; cholesterol-10, which has an average number of moles of oxyethylene groups added of 10; and cholesterol-15, which has an average number of moles of oxyethylene groups added of 15. As the polyoxyethylene cholesterol, commercially available products can be used, and examples thereof include EMALEX CS-5, which is cholesterol-5, EMALEX CS-10, which is cholesterol-10, and EMALEX CS-15, which is cholesterol-15, all of which are manufactured by Nippon Emulsion Co., Ltd.

[0031] From the viewpoint of suppressing crystallization of the solid oil even long after application, component (D) preferably contains one or more selected from PEG-5 phytosterol, PEG-10 phytosterol, cholesterol-5, and cholesterol-10, more preferably contains one or more selected from PEG-5 phytosterol and cholesterol-5, and even more preferably contains PEG-5 phytosterol.

[0032] Component (D) may be used alone or in combination with other types, and from the viewpoint of suppressing the squeaky feeling on the skin after application and improving the moist feeling during application, the content is preferably 0.05 to 12 mass%, more preferably 0.08 to 5 mass%, even more preferably 0.15 to 3.5 mass%, even more preferably 0.5 to 2.5 mass%, and particularly preferably 0.6 to 1.4 mass% of the total composition.

[0033] In the present invention, the mass ratio (A) / (D) of component (A) to component (D) is preferably 0.01 to 50, more preferably 0.05 to 20, even more preferably 0.08 to 15, even more preferably 0.5 to 8, and particularly preferably 0.8 to 5, from the viewpoints of suppressing crystallization of the solid oil even long after application, improving skin smoothness after application, suppressing squeaky feeling of the skin after application, improving moist feeling during application, and improving skin permeability of the active ingredient into the skin after application.

[0034] In the present invention, the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.01 to 50, more preferably 0.05 to 20, even more preferably 0.12 to 15, and even more preferably 0.8 to 3, from the viewpoints of suppressing crystallization of a solid oil even long after application, improving skin smoothness and suppressing a squeaky feeling of the skin after application, improving a moist feeling during application, and improving skin permeability of an active ingredient into the skin after application.

[0035] In the present invention, the mass ratio (C) / (D) of component (C) to component (D) is preferably 0.1 to 150, more preferably 1 to 100, even more preferably 1.5 to 20, even more preferably 1.8 to 15, and particularly preferably 7 to 13, from the viewpoints of suppressing crystallization of a solid oil even long after application, improving skin smoothness after application, suppressing squeaky feeling of the skin after application, improving moist feeling during application, and improving skin permeability of an active ingredient into the skin after application.

[0036] In the present invention, the content of water as component (E) is preferably 20 to 90 mass % of the total composition, more preferably 30 to 80 mass %, and even more preferably 40 to 70 mass %, from the viewpoint of improving moist feeling during application.

[0037] The oil-in-water emulsion composition of the present invention may further contain (F) an ionic surfactant, which can improve the smoothness of the skin after application. As the ionic surfactant of component (F), those commonly used in cosmetic preparations are preferred, including anionic surfactants and cationic surfactants. Examples of anionic surfactants include N-acylamino acids such as N-acyl glutamic acids such as N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, and N-myristoyl-L-glutamic acid; fatty acids; alkyl ether carboxylic acids; polyoxyethylene alkyl ether carboxylic acids; acyl lactic acid; N-acyl methyl alanine; N-acyl sarcosine; diacyl amino acids and their salts; alkane sulfonic acids; α-olefin sulfonic acids; α-sulfofatty acid methyl esters; acyl isethionic acids; and alkyl esters such as alkyl esters. sulfonate types such as N-acyl methyl taurines such as N-aminosulfosuccinic acid, N-myristoyl-N-methyl taurine, N-lauroyl-N-methyl taurine, N-stearoyl-N-methyl taurine, and salts thereof; sulfate types such as alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl ether sulfates, polyoxyethylene alkyl ether sulfates, fatty acid alkanolamide sulfates, and salts thereof; and phosphate types such as alkyl phosphates, polyoxyethylene alkyl ether phosphates, and salts thereof. From the viewpoint of improving the smoothness of the skin after application, the anionic surfactant preferably contains one or more selected from N-acylamino acids, N-acylmethyltaurines, and salts thereof, more preferably contains N-acylmethyltaurines and salts thereof, and even more preferably contains N-stearoyl-N-methyltaurine and salts thereof.

[0038] Examples of the salt structure constituting the anionic surfactant include alkali metal salts such as sodium and potassium, basic amino acid salts such as L-arginine, L-histidine, and L-lysine, and alkanolamine salts such as triethanolamine. Alkali metal salts are preferred, and sodium salts are more preferred. The sodium salt of N-stearoyl-N-methyltaurine is called sodium N-stearoyl-N-methyltaurine, and is also referred to as Na stearoylmethyltaurine.

[0039] Examples of cationic surfactants include monoalkyltrimethylammonium salts such as octyltrimethylammonium chloride, decyltrimethylammonium chloride, lauryltrimethylammonium chloride, tetradecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, hexadecyltrimethylammonium bromide, stearyltrimethylammonium chloride, and behenyltrimethylammonium chloride; dialkyldimethylammonium salts such as didecyldimethylammonium chloride and distearyldimethylammonium chloride; and trialkylmethylammonium salts. Among these, it is preferable to include at least one selected from monoalkyl trimethyl ammonium salts and dialkyl dimethyl ammonium salts, and more preferably to include dialkyl dimethyl ammonium salts. It is also preferable to include at least one selected from behenyl trimethyl ammonium chloride and distearyl dimethyl ammonium chloride, and more preferably to include distearyl dimethyl ammonium chloride. Distearyl dimethyl ammonium chloride is also referred to as distearyl dimonium chloride.

[0040] From the viewpoints of suppressing crystallization of a solid oil even long after application, improving skin smoothness after application, suppressing squeaky feeling on the skin after application, and improving moist feeling during application, component (F) preferably contains one or more selected from N-acylmethyltaurine and salts thereof, and dialkyldimethylammonium salts, more preferably contains one or more selected from sodium N-stearoyl-N-methyltaurate and distearyldimethylammonium chloride, and even more preferably contains sodium N-stearoyl-N-methyltaurate.

[0041] The ionic surfactants of component (F) can be used alone or in combination of two or more. From the viewpoint of improving the smoothness of the skin after application, the content is preferably 0.01 to 5 mass%, more preferably 0.05 to 3 mass%, and even more preferably 0.1 to 1 mass% of the total composition.

[0042] The oil-in-water emulsion composition of the present invention may further contain a nonionic surfactant other than component (D) to improve storage stability. Note that the nonionic surfactant is not included in component (B). Examples of the nonionic surfactant include glycerin fatty acid esters such as glyceryl stearate, glycerin monobehenate, and polyglyceryl diisostearate, and sorbitan fatty acid esters such as sorbitan monostearate. The nonionic surfactants can be used alone or in combination of two or more. From the viewpoint of improving the smoothness of the skin after application, the content is preferably 0.01 to 5 mass % of the total composition, more preferably 0.05 to 3 mass %, and even more preferably 0.1 to 1 mass %.

[0043] The oil-in-water emulsion composition of the present invention may further contain a water-soluble thickener, which can improve the moist feeling during application. Examples of the water-soluble thickener include acrylic acid-based polymers such as polyacrylic acid, carboxyvinyl polymers, and alkyl-modified carboxyvinyl polymers, polysaccharide-based polymers such as xanthan gum and hydroxypropylmethylcellulose, and urethane-based polymers. From the viewpoint of improving storage stability, it is preferable to contain an acrylic acid-based polymer, more preferably to contain one or more selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and even more preferably to contain a carboxyvinyl polymer.

[0044] The water-soluble thickeners can be used alone or in combination of two or more. From the viewpoint of improving the moist feeling during application, the content is preferably 0.01 to 1 mass % of the total composition, more preferably 0.05 to 0.8 mass %, and even more preferably 0.1 to 0.5 mass %.

[0045] The oil-in-water emulsion composition of the present invention may contain, in addition to the above-mentioned components, components that are usually used in cosmetics, such as oil components other than those mentioned above, surfactants other than those mentioned above, antioxidants, fragrances, preservatives, pH adjusters, blood circulation promoters, cooling agents, antiperspirants, germicides, skin activators, moisturizers, cooling agents, colorants, etc.

[0046] The oil-in-water emulsion composition of the present invention can be produced according to a conventional method. For example, an oil component containing components (A), (B) and (D) is heated and mixed at 85° C. or higher to prepare an oil component dissolved phase, and an aqueous component containing components (C) and (E) is heated and mixed at 65° C. or higher to prepare an aqueous component dissolved phase. The aqueous component dissolved phase heated to 65° C. or higher is added to the oil component dissolved phase heated to 85° C. or higher while stirring, and the mixture is cooled to 25° C. to produce an oil-in-water emulsion composition.

[0047] The oil-in-water emulsion composition of the present invention is suitable as an oil-in-water emulsion cosmetic, and can be applied as a skin cosmetic, such as makeup cosmetics such as a makeup base, foundation, concealer, blusher, eyeshadow, mascara, eyeliner, eyebrow, overcoat agent, lipstick, etc., ultraviolet protection cosmetics such as a sunscreen lotion, a sunscreen cream, etc., skin care cosmetics such as a skin care lotion, a skin care cream, a BB cream, a beauty serum, etc. Among them, skin care cosmetics are preferred. EXAMPLES

[0048] Examples 1 to 15, Comparative Examples 1 to 5 Oil-in-water emulsion compositions having the compositions shown in Tables 1 and 2 were prepared and evaluated for crystallization inhibition after application, skin smoothness after application, lack of squeaking sensation after application, and moist feeling upon application. The results are shown in Tables 1 and 2.

[0049] (Manufacturing method) A carboxyvinyl polymer was dispersed in a portion of component (E), and an aqueous solution of potassium hydroxide dissolved in a portion of component (E) was added thereto with stirring to obtain a polymer phase. The polyhydric alcohol other than component (C), components (A), (B) and (D) were mixed under heating at 85° C. or higher to obtain an oil component dissolved phase. Components (C), (F) and the remaining component (E) were mixed while heating at 65° C. or higher to obtain an aqueous component dissolved phase. While stirring the oily component dissolved phase heated to 85°C or higher, the aqueous component dissolved phase heated to 65°C or higher was added, cooled to 25°C, and the polymer phase was added and stirred to obtain an oil-in-water emulsion composition.

[0050] (Evaluation method) (1) Suppression of crystallization after application: 2 μL / cm of each oil-in-water emulsion composition was applied to a glass slide. 2 The surface was observed under a microscope after 4 and 6 hours, and evaluated based on the presence or absence of crystallization using the following three-level scale. ◎: No crystallization occurred up to 6 hours after application. ◯: No crystallization occurred until 4 hours after application, and partial crystallization occurred after 6 hours. ×: Crystallization occurred 4 hours after application.

[0051] (2) Smoothness of skin after application: Three expert evaluators applied 0.1 g of each oil-in-water emulsion composition to the back of the hand and let it sit for 5 seconds. After that, they touched the skin to which it had been applied and performed a sensory evaluation of smoothness according to the following criteria. The results were shown as the total score given by the three expert evaluators. 5;Very smooth. 4;Smooth. 3;Somewhat smooth. 2;Not very smooth. 1;Not smooth.

[0052] (3) No creaking feeling on the skin after application: Three expert evaluators applied 0.1 g of each oil-in-water emulsion composition to the back of the hand and let it sit for 5 seconds. After that, they touched the skin to which it had been applied and performed a sensory evaluation of the squeaky sensation according to the following criteria. The results were shown as the total score given by the three expert evaluators. 5;No squeaking sensation at all. 4;No squeaking sensation. 3: There is a slight creaking sensation. 2;I feel a creaking sensation. 1;It feels very squeaky.

[0053] (4) Moisturizing feeling upon application: Three expert evaluators applied 0.1 g of each oil-in-water emulsion composition to the back of the hand and rubbed it in for 5 seconds, after which the moist feeling of the skin during application was evaluated according to the following criteria. The results were shown as the total score given by the three expert evaluators. 5: Feels very moist. 4;It feels moist. 3: Feels slightly moist. 2;It doesn't feel very moisturizing. 1: It doesn't feel moisturizing.

[0054] [Table 1]

[0055] [Table 2]

[0056] Example 16, Comparative Examples 6 and 7 Oil-in-water emulsion compositions having the compositions shown in Table 3 were prepared in the same manner as in Examples 1 to 15, and were evaluated for crystallization inhibition after application, skin smoothness after application, absence of squeaking sensation after application, and moist feeling upon application. The results are also shown in Table 3. In addition, skin permeability was evaluated using an artificial membrane, and the results are shown in Figure 1.

[0057] (Evaluation method) (5) Skin permeability using artificial membrane: Franz-type diffusion cell (applicable area: 1 cm 2 Strat-M (Merck) was placed on a 30-mm thick paper liner (Permegia) so that the non-glossy side was in contact with the receptor liquid (N=5). The receptor side was filled with purified water. The Strat-M was applied with the recommended amount of coating (0.002 g / cm 2 ) was applied to the specimen and then placed in an incubator (temperature 32±1°C, humidity 50±2%). After 4 hours, the surface was wiped with cotton soaked in a 0.5% aqueous solution of sodium lauryl sulfate, and Strat-M and the receptor fluid were collected. N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide was extracted with methanol and quantified using ultra-high performance liquid chromatography (Nexera-i (Shimazu)) and a column (Inertsil ODS-HL HP (150×2.1 mm, 3 μm)).

[0058] [Table 3]

[0059] Prescription Examples 1-4 The oil-in-water emulsion compositions having the compositions shown in Tables 4 to 7 were produced in the same manner as in Examples 1 to 15. They inhibited crystallization even long after application, left the skin smooth and free of squeaking after application, provided a moist feeling upon application, and had excellent skin permeability.

[0060] [Table 4]

[0061] [Table 5]

[0062] [Table 6]

[0063] [Table 7]

Claims

1. The following components (A), (B), (C), (D), and (E): (A) one or more selected from cholesterol and phytosterols, (B) an oil agent other than component (A) that is solid at 25°C; (C) a trihydric or higher polyhydric alcohol, (D) one or more selected from polyoxyethylene phytosterols and polyoxyethylene cholesterols having an average number of moles of oxyethylene groups added of 2 to 18, (E) Water An oil-in-water emulsion composition comprising:

2. 2. The oil-in-water emulsion composition according to claim 1, wherein the mass ratio (B) / (D) of component (B) to component (D) is 0.01 to 50.

3. 3. The oil-in-water emulsion composition according to claim 1, wherein the mass ratio (C) / (D) of the component (C) to the component (D) is 0.1 to 150.

4. The oil-in-water emulsion composition according to claim 1 or 2, further comprising (F) an ionic surfactant.

5. 3. The oil-in-water emulsion composition according to claim 1, wherein component (B) comprises one or more members selected from the group consisting of ceramides and phospholipids.

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