Skin external composition

Abstract

To provide a skin external composition excellent in ease of scooping in use, spreadability during application and skin compatibility, by increasing a value of angular frequency of a sol-gel transition point in dynamic viscoelasticity although containing a hydrophobic modified polyether urethane.SOLUTION: A skin external composition is prepared which contains (A) a hydrophobic modified polyether urethane and (B) one or two or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin and tranexamic acids.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for topical application to the skin. More specifically, the present invention relates to a hydrophobically modified polyether urethane. , as well as nicotinamide, vitamin C derivatives, arbutin, and tranexamic acid. The present invention relates to a composition containing one or more components selected from the group consisting of: [Background technology]

[0002] The present invention relates to a hydrophobically modified polyether urethane (HEUR), which is a type of water-soluble thickener. Once the gel is formed, it has the property of returning to its original state even if it is broken. Therefore, for example, Patent Document 1 discloses that hydrophobically modified polyether urethane Manufactures oil-in-water emulsion cosmetics that are gel-like and have a unique bouncy elasticity and are stable at high temperatures. It is used to [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2016-088868 A Summary of the Invention [Problem to be solved by the invention]

[0004] The high recovery of the gel of the hydrophobic modified polyether urethane mentioned above makes it possible to When used in a strip-shaped skin topical composition, the composition does not lose its original shape even when pressure is applied with fingers, etc. To achieve this, a composition containing hydrophobically modified polyether urethane is applied to the skin with a finger or the like. If you try to scoop it up, the composition will remain in clumps and will tend to slip through your fingers. The problem is that the composition is difficult to spread and difficult to apply. There were issues with it, such as it being sticky and not blending well with the skin.

[0005] One of the factors that causes these problems with hydrophobically modified polyether urethane is the dynamic viscoelasticity. In the measurement of the angular frequency dependence of the storage modulus (G') and loss modulus (G") in the elasticity measurement The angular frequency of the sol-gel transition point where G′=G″ is the hydrophobically modified polyether urethane. In skin topical compositions containing the drug, the drug is generally small, and as a result, it is difficult to scoop it up with the fingers or apply it. It is thought that the composition did not exert sufficient viscosity during the process of deforming the formulation. Ta.

[0006] Therefore, in the present invention, even if a hydrophobically modified polyether urethane is contained, the dynamic viscoelasticity is not affected. The angular frequency of the gel-gel transition point is large, making the composition easy to scoop, easy to spread when applied, and The objective of the present invention is to provide a composition for external use on the skin that is excellent in compatibility with the skin. [Means for solving the problem]

[0007] As a result of extensive investigation, the present inventors have found that (A) hydrophobically modified polyether urethane and (B ) Nicotinamide, vitamin C derivatives, arbutin and tranexamic acid By containing one or more components selected from the above, the dynamic viscoelasticity of the skin-containing composition can be improved. The inventors have found that the angular frequency of the sol-gel transition point in the sol-gel reaction can be increased by the above method. This has led to the idea that...

[0008] That is, the present invention provides the following composition for external application to skin: Section 1. (A) hydrophobically modified polyether urethane, and (B) Nicotinamide, vitamin C derivatives, arbutin and tranexamic acid One or more ingredients selected from the group A composition for external application to the skin comprising: Section 2. The component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I): Item 1, a composition for external application to skin: R 1 -{(OR 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O) n -R 5 ] h} m (I) (In the ceremony R 1 represents a hydrocarbon group, R 2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms R 3 may have a urethane bond, may be a straight chain, branched chain, aliphatic ring, or aromatic ring R represents a hydrocarbon group containing 5 represents a branched hydrocarbon group; m is an integer of 2 or more; wherein h is an integer of 1 or more, and k and n are each independently an integer in the range of 0 to 1000. , k+n≧1). Section 3. Further, (C) a composition comprising phenoxyethanol, dipropylene glycol and an amphiphilic component Item 3. The composition for external use on the skin according to item 1 or 2, which contains one or more ingredients selected from the group consisting of Composition. Section 4. The amphiphilic component of the component (C) is 2-methacryloyloxyethyl phosphorylcholine. A polymer having a carbon number of 5 to 10, a divalent carboxylic acid ester, an alkanediol having a carbon number of 5 to 10, and the following chemical compound One or two selected from the group consisting of alkylene oxide derivatives represented by formula (II): The composition for external application to skin according to any one of items 1 to 3, Z-[O-(AO) a (EO) b -(BO) c -H] n (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms with n hydroxy groups removed. is a radical obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average mole numbers of AO, EO, and BO, respectively. independently range from 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different, When Z is a hydrogen atom, n is 1. Effect of the Invention

[0009] According to the present invention, the angular frequency value of the sol-gel transition point in dynamic viscoelasticity is increased, and A hydrophobic modified polyether wand that is easy to scoop when used, spreads easily when applied, and blends well with the skin. A retinal-containing composition for topical application to the skin is obtained. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] In this specification, the unit of content "mass%" is synonymous with "g / 100 g".

[0011] The composition for external use on the skin of the present invention comprises (A) a hydrophobically modified polyether urethane and (B) a nicotinamide. selected from the group consisting of tin amides, vitamin C derivatives, arbutin and tranexamic acids It contains one or more ingredients that are

[0012] [Component (A)] The hydrophobically modified polyether urethane contained in the topical skin composition as component (A) of the present invention is a polymer having urethane bonds modified with hydrophobic groups, and is used to thicken aqueous compositions. Used for gelation.

[0013] The hydrophobically modified polyether urethane used in the present invention is preferably represented by the following chemical formula (I): Represented. R 1 -{(OR 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O) n -R 5 ] h} m (I) (In the ceremony R 1 represents a hydrocarbon group, R 2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms R 3 may have a urethane bond, may be a straight chain, branched chain, aliphatic ring, or aromatic ring R represents a hydrocarbon group containing 5 represents a branched hydrocarbon group; m is an integer of 2 or more; wherein h is an integer of 1 or more, and k and n are each independently an integer in the range of 0 to 1000. , k+n≧1).

[0014] R 1 From the viewpoint of achieving the effects of the present invention remarkably, the hydrocarbon group preferably has 2 to 1 carbon atoms. 2 alkyl or alkylene group, more preferably an alkyl or alkylene group having 2 to 4 carbon atoms. It is an alkylene group, and more preferably an ethyl group having 2 carbon atoms.

[0015] R 2 and R 4 Each independently represents an alkylene group having 2 to 4 carbon atoms, and exhibits the effects of the present invention. From the viewpoint of being particularly effective, an alkylene group having 2 carbon atoms (ethylene group) is preferred.

[0016] R 3 may have a urethane bond, and may be linear, branched, or have an aliphatic or aromatic ring. Among them, from the viewpoint of significantly exhibiting the effects of the present invention, a straight-chain A hydrocarbon group is preferred.

[0017] R 3 From the viewpoint of significantly exhibiting the effects of the present invention, the number of carbon atoms is preferably 1 to 10, and more preferably Preferably, it is 2 to 8. R 3 A preferred example of the hydrocarbon group is a hexamethylene group.

[0018] R 5 is a branched hydrocarbon group, and the number of carbon atoms is not particularly limited, but From the viewpoint of exhibiting a remarkable effect, the number of units is preferably 8 to 36, more preferably 10 to 30, and further preferably Usually it is 12 to 24. R 5 A preferred example of the hydrocarbon group is a 2-dodecyldodecyl group.

[0019] The value of m is an integer of 2 or more, and is preferably 2.

[0020] From the viewpoint of significantly exhibiting the effects of the present invention, the value of h is 1 or more, and preferably 1. .

[0021] k, which is the number of repetitions of O-R2, and n, which is the number of repetitions of R4-O, are each independently 0 to 1. 000, and k and n cannot both be 0. That is, k+n is 1 or greater.

[0022] From the viewpoint of significantly exhibiting the effects of the present invention, the value of k is preferably 1 to 500, more preferably Preferably, the range is 10 to 400, more preferably 50 to 300, and even more preferably 100 to 300. be.

[0023] From the viewpoint of significantly exhibiting the effects of the present invention, the value of n is preferably 1 to 200, more preferably The range is preferably 5 to 200, and more preferably 10 to 100.

[0024] The hydrophobically modified polyether urethane used in the present invention has a remarkable effect on the effects of the present invention. From this viewpoint, a (PEG-240 / decyltetradeceth-20 / HDI) copolymer is preferable. (ADEKA NOL GT-700, ADEKA NOL GT-730: manufactured by ADEKA Corporation) and Tealess-100 / PEG-136 / HDI copolymer (RHEOLUXE 811:E Rementis Japan Co., Ltd.), and more Preferably, it is a (PEG-240 / Decyltetradeceth-20 / HDI) copolymer. .

[0025] The total content of the component (A) is not particularly limited, and may vary depending on the type of water-soluble polysaccharide and the type of other blended components. However, from the viewpoint of significantly achieving the effects of the present invention, Based on the total amount, it is preferably 0.1 mass% or more, more preferably 0.2 mass% or more, and even more preferably It is preferably 0.5% by mass or more, and even more preferably 1% by mass or more. The total content of the component (A) is preferably 6% by mass or less based on the total amount of the composition for external use on skin. More preferably, the amount is 5% by mass or less, even more preferably, the amount is 4.5% by mass or less, and even more preferably, the amount is 4. It is less than mass %. The total content of the component (A) is preferably 0.1 to 6% by mass based on the total amount of the composition for external use on skin. %, more preferably 0.2 to 5 mass%, and even more preferably 0.5 to 4.5 mass%. The content is more preferably 1 to 4% by mass.

[0026] [(B) Component] As the component (B) of the skin topical composition of the present invention, nicotinamide, a vitamin C derivative, One or more ingredients selected from the group consisting of arbutin and tranexamic acids are used. In particular, the composition for external use on the skin of the present invention contains nicotinamide, vitamin C derivatives, and and tranexamic acids. Preferably, one or more selected from the group consisting of nicotinamide and vitamin C derivatives. is more preferred, and nicotinamide is even more preferred.

[0027] As used herein, the term "salt" refers to a pharma- ceutically acceptable salt. Salts with organic bases (e.g., trimethylamine salts, triethylamine salts, monoethanolamine salts) salts with tertiary amines such as ethanolamine salts, triethanolamine salts, pyridine salts, arginine, etc. salts with inorganic bases (e.g., ammonium salts, sodium salts, etc.) Salt, alkaline metal salts such as potassium salts, alkaline earth salts such as calcium salts and magnesium salts salts with inorganic acids (hydrochlorides, sulfates, nitrates, odorants, etc.), hydrochlorides, phosphates, etc.), salts with organic acids (acetates, butyrates, fumarates, maleates, etc.) Among them, preferred salts include triethanolamine salts, sodium salts, The preferred salts are potassium, magnesium, or zinc salts, and more preferred salts are sodium, calcium, or zinc salts. The salt is a lithium salt or a magnesium salt.

[0028] Nicotinamide is an amide compound of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin. It may be an extract from a natural product, It may be a compound synthesized by a known method. In addition to promoting blood circulation and improving rough skin, it also promotes melanin production. It is known to have anti-aging and whitening effects.

[0029] Vitamin C derivatives are obtained by replacing part of ascorbic acid with other atoms or substituents. The compound is a stereoisomer of ascorbic acid or a salt thereof. Examples of such compounds include dehydroascorbic acid; 3-O-ethylascorbic acid (VC ethyl). ), 2-O-ethyl ascorbic acid, 3-O-cetyl ascorbic acid, and other ascorbic acids Alkyl esters; Ascorbyl tetraisopalmitate (tetra 2-hexyldecanoate Ascorbyl), Ascorbyl Palmitate, Ascorbyl Dipalmitate, Stearin Ascorbyl Acid, L-Ascorbyl Dioleate, L-Ascorbyl Tristearate Ascorbyl ascorbyl triphosphate, ascorbyl tripalmitate, ascorbyl trioleate, etc. Acid; Glyceryl Ascorbate, Bisglyceryl Ascorbate, Alkylglyceryl Ascorbic acid glycerol esters such as ascorbic acid; ascorbic acid glucoside (V Ascorbic acid derivatives such as ascorbic acid 2-glucoside (AA2G) Glycosides; Ascorbyl phosphate, magnesium ascorbyl phosphate (L-ascorbyl phosphate) (Mg), Sodium Ascorbyl Phosphate, Isostearyl Ascorbyl Phosphate ascorbic acid monophosphate esters such as ascorbyl palmitate phosphate; Ascorbic acid diphosphate ester;Ascorbic acid triphosphate ester;Ascorbic acid sulfate ester (Ascorbyl / tocopheryl) phosphate, ascorbyl tocopheryl maleate, etc. Tocopherol ascorbate derivatives; ascorbic acid methylsilanol and other ascorbic acids Examples of the silicone include silicone phosphates and their salts, and preferably alkyl ascorbate. Ester, Ascorbic Acid Monophosphate, L-Ascorbic Acid Glucoside, Ascorbic Acid tocopherol ascorbate derivatives, glycerol ascorbate esters and their salts More preferably, the alkyl ascorbate is one or more selected from the group consisting of alkyl ascorbate. Ester, Ascorbic Acid Monophosphate, L-Ascorbic Acid Glucoside, Ascorbic Acid One or more selected from the group consisting of tocopherol carboxylate derivatives and salts thereof It is.

[0030] A preferred vitamin C derivative as component (B) of the present invention is tetraisopalmitin. Ascorbyl acetate, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, Disodium ascorbic acid sulfate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid Ascorbic Acid, Ascorbic Acid-2-Glucoside, Isostearyl Ascorbyl Phosphate Disodium Sodium, Trisodium Ascorbyl Palmitate Phosphate; Glyceryl Ascorbate, Hexyl 3-glyceryl ascorbate, hexyl 3-glyceryl ascorbate, 3-glyceryl Ascorbic Acid, Myristyl 3-Glyceryl Ascorbate, 3-Lauryl Glyceryl Ascorbic Acid, (Ascorbyl / Tocopheryl) Phosphate, (Ascorbyl / Tocopheryl) potassium phosphate, ascorbyl tocopheryl maleate, etc. are preferably used. , Sodium Ascorbyl Phosphate, Magnesium Ascorbyl Phosphate, 2-O-Ethyl A Ascorbic acid, 3-O-ethyl ascorbic acid; Ascorbic acid-2-glucoside, iso Disodium stearyl ascorbyl phosphate, trisodium ascorbyl palmitate phosphate Ascorbic Acid, 3-Glyceryl Ascorbate, Bisglyceryl Ascorbate, Hexyl 3-Glyceryl Ascorbate Lyceryl Ascorbate, 3-Glyceryl Ascorbate, Myristyl 3-Glyceryl Ascorbate Ascorbic Acid, 3-Laurylglyceryl Ascorbate, (Ascorbyl / Tocopheryl ) potassium phosphate, and ascorbyl tocopheryl maleate More preferably, sodium ascorbyl phosphate, ascorbyl phosphate, Magnesium phosphate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, Ascorbic acid-2-glucoside, disodium isostearyl ascorbyl phosphate, Trisodium Ascorbyl Phosphate and Ascorbyl / Tocopheryl Phosphate and more preferably, ascorbyl sulfate, Sodium ascorbyl phosphate, magnesium ascorbyl phosphate, 2-O-ethyl ascorbic acid ascorbic acid, 3-O-ethyl ascorbic acid, and ascorbic acid-2-glucoside More preferably, it is magnesium ascorbyl phosphate. Ascorbic acid, 3-O-ethyl ascorbic acid, and ascorbic acid-2-glucoside One or more selected from the above, particularly preferably 3-O-ethyl ascorbic acid. be.

[0031] Arbutin is obtained by combining hydroquinone with glucose. Arbutin is a type of arbutin that has an α-linkage and β-linkage. As the component (B) of the present invention, either α-arbutin or β-arbutin is preferable. Any suitable arbutin may be used, with β-arbutin being more preferred.

[0032] Tranexamic acids include tranexamic acid, derivatives of tranexamic acid, and their salts. Tranexamic acid is a compound found in the It may be synthesized by known methods and is not available commercially. The derivatives of tranexamic acid may be pharmacologically or physiologically acceptable. As long as the compound is suitable, it is not particularly limited, and examples thereof include a dimer of tranexamic acid; methyl tranexamate amides of tranexamic acid such as tranexamic acid ethylamide; Hydroquinone esters; Vitamin A esters, Vitamin E esters, Vitamin C esters Tranexamic acid vitamin esters such as tranexamic acid gentisic acid ester; Tranexamic acid vitamin ester; Examples of tranexamic acid ester derivatives include cetyl tetrahydrocanthate and salts thereof. These tranexamic acid derivatives may be synthesized by known methods and are available as commercially available products. Among them, tranexamic acid is preferred as the component (B) of the present invention. I wish.

[0033] In the composition for external use on the skin of the present invention, the total content of the component (B) relative to the total amount of the composition for external use on the skin is appropriately set depending on the balance with other components, but from the viewpoint of significantly exhibiting the effects of the present invention, Therefore, it is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably is 0.5% by mass or more, and even more preferably 1% by mass or more. The total content of the (B) component is preferably 10% by mass or less based on the total amount of the composition for external use on skin. More preferably, it is 8% by mass or less, further preferably, it is 6% by mass or less, and particularly preferably, it is 5% by mass or less. Below. The content of the component (B) is preferably 0.01 to 20 mass % based on the total amount of the composition for external use on skin. %, more preferably 0.01 to 10 mass%, even more preferably 0.1 to 8 mass%, and even more preferably The content is preferably 0.5 to 6 mass %, and particularly preferably 1 to 5 mass %.

[0034] (B) When nicotinamide is contained as an ingredient, the content of nicotinamide is Preferably, the amount is 1.5 to 20% by mass, more preferably 2 to 15% by mass, based on the total amount of the composition for external use on skin. % by mass, more preferably 3 to 10% by mass, and even more preferably 3 to 8% by mass.

[0035] (B) When vitamin C derivatives and their salts are contained as ingredients, vitamin C derivatives The content of these salts is preferably 0.01 to 10% based on the total amount of the composition for external use on skin. % by mass, more preferably 0.5 to 8% by mass, even more preferably 1 to 5% by mass, and even more preferably The content is preferably 1 to 3 mass %.

[0036] When arbutin is contained as component (B), the content of arbutin in the composition for external use on skin is Preferably, the content is 0.01 to 5% by mass, more preferably 0.1 to 4.8% by mass, based on the total amount. , more preferably 0.5 to 4.5 mass%, even more preferably 0.5 to 4 mass%, and particularly preferably The content is preferably 1 to 3 mass %.

[0037] (B) When tranexamic acids are contained as an ingredient, the content of tranexamic acids is Preferably, the amount is 0.01 to 10% by mass, more preferably 0.5% by mass, based on the total amount of the composition for external use on the skin. up to 8% by mass, more preferably 0.5 to 5% by mass, even more preferably 1 to 3% by mass, particularly The content is preferably 1.2 to 3 mass %.

[0038] The total content of the component (B) per part by mass of the total content of the component (A) in the composition for external use on the skin of the present invention The content is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.0 0.002 to 10,000 parts by mass, more preferably 0.001 to 8,000 parts by mass, and even more preferably is preferably 0.01 to 5000 parts by mass, more preferably 0.1 to 1000 parts by mass, and particularly preferably The content is usually 0.5 to 500 parts by mass.

[0039] [(C) component] The composition for external use on the skin of the present invention is, from the viewpoint of further enhancing the effect of the present invention, In addition to B), the ingredient (C) contains phenoxyethanol, dipropylene glycol, The composition contains one or more components selected from the group consisting of an amphiphilic component, an isocratic component, and an amphiphilic component.

[0040] Amphiphilic components have both hydrophilic and hydrophobic groups (lipophilic groups) in one molecule, resulting in This refers to all compounds that have affinity for both the aqueous phase and the oil phase (organic phase).

[0041] Such an amphiphilic component is not particularly limited, but may be, for example, an alkylene oxide. Derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, dicarboxylic acids esters, and alkanediols having 5 to 10 carbon atoms. These compounds may be used alone or in combination of two or more. .

[0042] The component (C) is preferably phenoxyethanol, an aryl group represented by the following general formula (II): Alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine methacryloyloxyethyl Butyl acrylate copolymer, (eicosanedioic acid / tetradecane diacid) decaglyceryl, cyclohexyl Bisethoxydiglycol xanthanedicarboxylate, diethylhexyl succinate, di One member selected from the group consisting of ethoxyethyl and alkanediols having 5 to 10 carbon atoms Or two or more types.

[0043] The alkylene oxide derivative used in the present invention is represented by the following formula (II).

[0044] Z-[O-(AO) a (EO) b -(BO) c -H] n (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms with n hydroxy groups removed. is a radical obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average mole numbers of AO, EO, and BO, respectively. independently range from 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different, When Z is a hydrogen atom, n is 1.

[0045] The alkylene oxide derivative is a compound represented by the following general formula (III): This is also possible.

[0046] Z-[O-(AO) a (EO) b -H] n (III) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms with n hydroxy groups removed. is a radical obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; a and b are the average number of moles of AO, EO, and BO added, respectively, and are independently a and b are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's and b's may be the same or different, When Z is a hydrogen atom, n is 1.

[0047] In the chemical formulas (II) and (III), Z is, from the viewpoint of significantly exhibiting the effects of the present invention, , preferably a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, Trimethylolpropane, Erythritol, Pentaerythritol, Alkyl glucoside , diglycerin, xylitol, dipentaerythritol, sorbitol, inositol , sucrose, trehalose, maltitol or a hydroxy compound having 1 to 30 carbon atoms is preferably a group obtained by removing n hydroxy groups from Atoms or alkyl monoalcohols having 4 to 24 carbon atoms, pentaerythritol, alkyl Glycoside, glycerin, diglycerin or sorbitol with n hydroxyl groups and more preferably a hydrogen atom, a group having 4 to 24 carbon atoms. n alkyl monoalcohols, alkyl glucosides, diglycerol or glycerin and even more preferably a radical obtained by removing the hydroxyl group of , alkyl monoalcohol having 4 to 24 carbon atoms, diglycerin or glycerin to n It is a group obtained by removing a hydroxy group.

[0048] In the chemical formulas (II) and (III), Z is an alkyl monoalcohol having 4 to 24 carbon atoms. In the case of alcohol, from the viewpoint of significantly achieving the effects of the present invention, butyl alcohol, tetradecane, etc. are particularly preferred. Cyltetraalcohol, cetanol, or stearyl alcohol is preferred, and butyl alcohol is preferred. Cole is preferred.

[0049] In the chemical formulas (II) and (III), when Z is an alkyl glucoside, From the viewpoint of exhibiting a remarkable effect, it is particularly preferable to use an alkylglucose having an alkyl group of 1 to 24 carbon atoms. Alkyl glucosides having 1 to 16 carbon atoms in the alkyl group moiety are preferred. More preferably, the alkyl group is an alkyl glucoside having 1 to 10 carbon atoms. Alkyl glucosides having a radical number of 1 to 5 carbon atoms are particularly preferred.

[0050] In the chemical formulas (II) and (III), AO is an oxyalkylene group having 3 to 4 carbon atoms, e.g. As examples, oxypropylene group, oxybutylene group (oxy n-butylene group, oxyisobutene group, oxyt-butylene group, oxytrimethylene group, oxytetramethylene group, etc. AO is preferably an oxypropylene group or an oxybutylene group, More preferably, it is an oxypropylene group. BO is an oxyalkylene group having 4 carbon atoms, for example, an oxybutylene group (oxyn -butylene group, oxyisobutylene group, oxyt-butylene group), oxytetramethylene A preferred example is an oxybutylene group.

[0051] In the alkylene oxide derivative used in the present invention, a, b, and c each independently represent Each of a, b, and c is preferably an integer of 1 to 200. More preferably, it is from 2 to 150, even more preferably from 2 to 100, and particularly preferably Usually it is between 2 and 70.

[0052] In chemical formula (II), a+b+ is the total number of AO, EO, and BO monomer units. From the viewpoint of significantly exhibiting the effects of the present invention, c is preferably 3 or more, more preferably 5 or more. , more preferably 10 or more, and preferably 450 or less, more preferably 350 It is more preferably 300 or less, and particularly preferably 250 or less.

[0053] In the chemical formulas (II) and (III), the total number of AO and EO monomer units is From the viewpoint of significantly exhibiting the effects of the present invention, a+b is preferably 3 or more, more preferably 5. More preferably, a+b is a value that is sufficient to significantly exhibit the effects of the present invention. From this viewpoint, it is preferably 400 or less, more preferably 300 or less, and further preferably 250 or less. , and particularly preferably 200 or less.

[0054] The molecular weight of the alkylene oxide derivative used in the present invention is such that the effect of the present invention is remarkable. From the viewpoint of the above, the molecular weight is preferably 120 or more, more preferably 200 or more, and further preferably 300 or more. or more, and particularly preferably 400 or more. The molecular weight of the alkylene oxide derivative is preferably 50,000 or less, more preferably It is preferably 10,000 or less, and more preferably 5,000 or less.

[0055] The properties of the alkylene oxide derivatives of the formulas (II) and (III) are such that the effects of the present invention are achieved. There is no limitation as long as the effect is achieved, but from the viewpoint of significantly achieving the effects of the present invention, it is preferable to use a It is a component that is semi-solid (including paste-like) to liquid at ℃.

[0056] In addition, such alkylene oxide derivatives include polyoxyalkylene glyceryl ethers. ester, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether sorbitol, polyoxyalkylene sorbitol, polyoxyalkylene erythritol ether, Polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceride ether, polyoxyalkylene trimethylolpropane, polyoxypropylene glycol Coal, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene Silitol, polyoxyalkylene dipentaerythritol, polyoxyalkylene ino Sitol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, polyoxyalkylene maltitol ether, etc. Oxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene glyceryl ether Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Ethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene Polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside , polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, Polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sol Bit, polyoxyethylene sorbitol, polyoxypropylene erythritol ether , polyoxyethylene erythritol ether, polyoxyethylene pentaerythritol Polyoxyethylene polyoxypropylene erythritol ether, polyoxyethylene Polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene Pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxyethylene Dipropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceride Ether, Polyoxyethylene trimethylolpropane, Polyoxypropylene trimethylolpropane Methylolpropane, Polyoxyethylene Polyoxypropylene Trimethylolpropane , polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol Polyoxybutylene polyoxyethylene polyoxypropylene glycol, polyoxy Diethylene xylitol, polyoxypropylene alkylene xylitol, polyoxyethylene Polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyoxypropylene di Pentaerythritol, polyoxyethylene dipentaerythritol, polyoxypropionate Resipentaerythritol, Polyoxyethylene inositol, Polyoxypropylene inositol Inositol, Polyoxyethylene Polyoxypropylene Inositol, Polyoxyethylene Sucrose ether, polyoxypropylene sucrose ether, polyoxyethylene Polyoxypropylene sucrose ether, polyoxyethylene trehalose ether, Polyoxypropylene trehalose ether, polyoxyethylene polyoxypropylene Trehalose ether, polyoxyethylene maltitol ether, polyoxypropylene Polyoxyethylene polyoxypropylene ether Preferably, one or more selected from the group consisting of Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Diethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside Coside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether Polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene Sorbitol, polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene Pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxyethylene Dipropylene diglyceryl ether, polyoxyethylene polyoxypropylene trimethyl Rollpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene Pyrene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol More preferably, one or more selected from the group consisting of recall, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxyethylene alkyl Glucoside, polyoxypropylene alkyl glucoside, polyoxybutylene polyoxy Ethylene polyoxypropylene alkyl glucoside, polyoxyethylene diglyceryl ether ether, polyoxypropylene diglyceryl ether, polyoxypropylene glycol , polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene Polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene More preferably, the alkyl ether is one or more selected from the group consisting of phenyl alkyl ethers. Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Diethylene polyoxypropylene methyl glucoside, Polyoxypropylene methyl glucoside Polyoxyethylene methyl glucoside, polyoxypropylene glycol, polio Polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene Polyoxypropylene glycol, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether It is even more preferable to use one or more selected from the group consisting of:

[0057] Such alkylene oxide derivatives are commercially available, but are not particularly limited to the following: , WILBRIDE S-753 (Polyoxybutylene Polyoxyethylene Polyoxyprop Propylene glyceryl ether (3B.O.) (8E.O.) (5P.O.)), WILB RIDE MG2070 (Polyoxybutylene Polyoxyethylene Polyoxypropylene methyl glucoside), Macbiobride MG-10E (polyoxyethylene methyl glucoside) Syd (10E.O.)), Macbiobride MG-20E (Polyoxyethylene methyl glycol) Lucoside (20E.O.)), Macbiobride MG-20P (Polyoxyethylene methyl Luglucoside (20P.O.), Macbiobride MG-10P, Unilube 5TP- 300KB (Polyoxyethylene polyoxypropylene pentaerythritol ether ( 5E.O.)(65P.O.)), Unilube 50MB-26 (Polyoxyethylene Poly Oxypropylene butyl ether (17E.O.) (17P.O.), Unilube 50 MB-168 (Polyoxyethylene polyoxypropylene butyl ether (37E.O. )(38P.O.)), Unilube 50MB-11 (Polyoxyethylene polyoxypropylene Pyrene butyl ether (9E.O.) (10P.O.)), Unisafe 10P-8 (Poly Oxyethylene polyoxypropylene cetyl ether (10E.O.) (8P.O.)) , Unilube MT-630B (Polyoxyethylene polyoxypropylene decyl tetradecyl Sil Ether (30E.O.) (6P.O.)), Sorbure GS-01 (Polyoxy Ethylene polyoxypropylene decyl tetradecyl ether (24E.O.) (13P. O.)), Unilube MS-70K (Polyoxypropylene stearyl ether (15P .O.)), Uniol HS-1600D (Polyoxypropylene sorbitol (25P. O.), Pronon #208 (Polyoxyethylene polyoxypropylene glycol (1 50E.O.)(35P.O.)), Uniol D-2000 (polypropylene glycol) (34P.O.)) Uniox G-1200 (Polyoxyethylene glycerin (26 EO)), Uniol TG-3000 (Polyoxypropylene glycerin (50P. O.)), Unilube DGP-700 (Polyoxypropylene diglyceryl ether (9 PO), Unilube DGP-950 (Polyoxypropylene diglyceryl ether) (14P.O.)) (all manufactured by NOF Corp.); SY-DP14T (polyoxypropylene Diglyceryl ether (14P.O.)), SY-DP9 (Polyoxypropylene diglyceryl Seryl ether (9P.O.)), SY-DP14T (Polyoxypropylene diglyceride Ether (14P.O.) (all manufactured by Sakamoto Pharmaceutical Co., Ltd.); Brownon GL-26 , (Polyoxyethylene glycerin (26E.O.)) (both manufactured by Aoki Oil Co., Ltd.), UPOL GP-1000 (Polyoxypropylene glyceryl ether (16P.O.) ), Newpol SP-750 (Polyoxypropylene sorbitol (10P.O.)) , Newpol PE-68 (Polyoxyethylene polyoxypropylene glycol (16 0E.O.)(30P.O.)), Newpol PE-78 (Polyoxyethylene polyoxyethylene Propylene glycol (150E.O.) (35P.O.)), Niupol GEP -2800 (Polyoxyethylene polyoxypropylene glyceryl ether (24E.O .)(24P.O.)(all manufactured by Sanyo Chemical Industries, Ltd.); NIKKOL SG-G2424( Polyoxyethylene polyoxypropylene glyceryl ether (24E.O.) (24P .O.), NIKKOL SG-DTD630 (Polyoxyethylene polyoxypropylene Indecyl tetradecyl ether (30E.O.) (6P.O.), NIKKOL SG- DTD620 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether ( 20E.O.)(6P.O.)), NIKKOL PEN-4612 (Polyoxyethylene Polyoxypropylene decyl tetradecyl ether (12E.O.) (6P.O.)) (All manufactured by Nikko Chemicals); GLUCAM P-10 (polyoxypropylene methylglucose) Coside (10P.O.)), GLUCAM P-20 (Polyoxypropylene methylglucose Coside (20P.O.)) GLUCAM E-10 (Polyoxyethylene methylglucosyl (10P.O.)), and GLUCAM E-20 (polyoxyethylene methylglucose Sid (20P.O.) (both manufactured by Lubrizol Corporation) and the like can be used.

[0058] As commercially available alkylene oxide derivatives, from the viewpoint of remarkably exhibiting the effects of the present invention, Unilube 50MB-26, Unilube 50MB-168, Uniol HS-1600D , Pronon #208, Pronon #124P, Uniol D-2000, Macbio Bride MG-10E, Macbio Bride MG-20E, Macbio Bride MG-10P, Macbio Obride MG-20P, WILBRIDE MG2070, Unilube 5TP-300 KB, Unilube 50TG-32, WILBRIDE S-753, Uniox G-1 200, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY -DP9, Nieuport GP-1000, Nieuport SP-750, Nieuport PE -68, Newpol PE-78, Newpol GEP-2800, NIKKOL SG -G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E- 10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKK OL SG-DTD630, Unilube MT-630B, Solvure GS-01, GL One or more selected from the group consisting of UCAM E-20 and Emulgen PP-290 Preferably, Unilube 50MB-26, Unilube 50MB-168, Uniol HS-1600 D, Pronon #208, Pronon #124P, Uniol D-2000, McBio-Brown MG-10E, MacBio Bride MG-20E, MacBio Bride MG-10P, Mac Biobride MG-20P, WILBRIDE MG2070, WILBRIDE S- 753, Uniox G-1200, Unilube 50TG-32, Unilube DGP-7 00, Unilube DGP-950, SY-DP14, SY-DP9, Newport GP- 1000, Nieuport SP-750, Nieuport PE-68, Nieuport PE-7 8, Newpol GEP-2800, NIKKOL SG-G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN- 4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, Nilube MT-630B, Sorbure GS-01, GLUCAM E-20 and Emul More preferably, the compound is one or more selected from the group consisting of PP-290 and PP-290. Unilube 50MB-26, Unilube 50MB-168, WILBRIDE S-7 53, WILBRIDE MG2070, MacBio Bride MG-20P, MacBio Bride Ido MG-10P, Macbio Bride MG-20E, Macbio Bride MG-10E, Yu Nilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKK OL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-D TD630, Unilube MT-630B, Solbure GS-01 and GLUCAM E It is more preferable that the compound is one or more selected from the group consisting of -20, Unilube 50MB-26, Unilube 50MB-168, WILBRIDE S- 753, WILBRIDE MG2070, MacBio Bride MG-20P, MacBio Ride MG-10P, Macbio Ride MG-20E, Macbio Ride MG-10E, Unilube DGP-700, Unilube DGP-950, GLUCAM P-10, GL From UCAM P-20, GLUCAM E-10, SY-DP14, and SY-DP9 It is even more preferable that the compound is one or more selected from the group consisting of:

[0059] The 2-methacryloyloxyethyl phosphorylcholine-containing polymer is This is a polymer obtained by polymerizing a monomer containing oxyethyl phosphorylcholine. The 2-methacryloyloxyethyl phosphorylcholine-containing polymer used in the present invention is In order to achieve a significant effect, Lipidure-PMB (2-methacryloyloxy) Diethylphosphorylcholine-Butyl methacrylate copolymer liquid, Polyquaternium-51) , and Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) ( Preferably, one or more selected from the group consisting of Lipoic Acid, Lipoic Acid (all manufactured by NOF Corp.) dure-PMB is more preferred

[0060] Dicarboxylic acid esters are compounds that combine dicarboxylic acids with glycols, glycol ethers, etc. It is a compound condensed with a hydroxy group, and is not particularly limited, for example, (eicosanedioic acid / Tetradecanedioic acid) decaglyceryl, cyclohexanedicarboxylate bisethoxydiglyceryl Cole, 1,4-cyclohexanedicarboxylate bis(triethylene glycol monoethyl ester) ether), bis(diethylene glycol monoethyl ether) adipate, adipic acid Bis(triethylene glycol monoethyl ether), and diethoxyethyl succinate, Diethylhexyl succinate is one of the most popular, especially (eicosanedioic acid / tetradecane diacid) Glyceryl, bisethoxydiglycol cyclohexanedicarboxylate, diethoxy succinate one or more selected from the group consisting of diethylhexyl succinate, Preferred are decaglyceryl (eicosanedioate / tetradecanediate) and cyclohexanediol. More preferably, one or two selected from the group consisting of bis(ethoxydiglycol) carboxylate Cyclohexanedicarboxylate bisethoxydiglycol is more preferred. Examples of the product include, but are not limited to, diethoxyethyl succinate (CRODAMOL DE S), diethylhexyl succinate (CRODAMOL OSU) (both from Crodaja) (manufactured by Pan Co., Ltd.), Neosolue-Aqua, Neosolue-AquaS ((A Cosanedioic acid / tetradecanediic acid (decaglyceryl), Neosolue-Aqulio ( Cyclohexanedicarboxylate bisethoxydiglycol) (both manufactured by Nippon Fine Chemicals Co., Ltd.) etc. are available.

[0061] In order to achieve the effects of the present invention more remarkably, the alkanediol preferably has 5 carbon atoms. The ratio is preferably from 1 to 10, more preferably from 5 to 8, and even more preferably from 5 to 6. For example, 1,2-penta from the group consisting of 1,2-hexanediol, 1,2-octanediol, and One or more selected from the above are preferred, and 1,2-pentanediol, 1,2-hexanediol, More preferably, the diol is 1,2-pentanediol. In addition, commercially available products include, but are not limited to, HYDROLITE-5 , HYDROLITE-5 Green (Symrise Co., Ltd.), KMO-6 (Osaka Organic Chemical Industry), Microcare Emollient PTGJ, Microcare Emollient ient HXD (manufactured by THOR), Diol PD, Diol PD-V (high-grade alcohol (Kolon Life Science, I Inc.), Lexgard® H (Inolex Chemical Com (manufactured by Pany) can be used.

[0062] When component (B) is a vitamin C derivative, component (C) is phenoxyethanol. , alkylene oxide derivatives, containing 2-methacryloyloxyethyl phosphorylcholine The group consisting of polymers, divalent carboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. It is preferable to use one or more selected from the following: alkylene oxide derivatives, 2-methylphenyl Thacryloxyethyl phosphorylcholine-butyl methacrylate copolymer, divalent carbo one selected from the group consisting of alkanediols having 5 to 10 carbon atoms, More preferably, two or more kinds are used, and Z is an alkyl monoalcohol having 4 to 24 carbon atoms or Formula (II), which is a group obtained by removing n hydroxy groups from glycerol Alkylene oxide derivatives, divalent carboxylic acid esters, and alkanes having 5 to 10 carbon atoms It is more preferable that the diol is one or more selected from the group consisting of diols. When the (B) component is arbutin, the (C) component is dipropylene glycol, Polymerization containing alkylene oxide derivatives and 2-methacryloyloxyethyl phosphorylcholine a divalent carboxylic acid ester, and an alkanediol having 5 to 10 carbon atoms; It is preferable to use one or more of the following: alkylene oxide derivatives, 2-methacrylamide, Trimethylsilyloxyethyl phosphorylcholine / butyl methacrylate copolymer, dicarboxylic acid One or two selected from the group consisting of esters and alkanediols having 5 to 10 carbon atoms More preferably, it is equal to or greater than this. When the component (B) is a tranexamic acid, the component (C) is dipropylene glycol. Contains alcohol, alkylene oxide derivatives, and 2-methacryloyloxyethyl phosphorylcholine A group consisting of polymers, divalent carboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. Preferably, the divalent carboxylate and the carbonyl group are one or more selected from the group consisting of divalent carboxylate and carbonyl group. One or more selected from the group consisting of alkanediols having 5 to 10 carbon atoms. More preferred.

[0063] The total content of the (C) component is not particularly limited, and may vary depending on the type of water-soluble polysaccharide and the type of other blended components. However, from the viewpoint of significantly achieving the effects of the present invention, Preferably, the total amount is 0.001% by mass or more, more preferably, 0.01% by mass or more. More preferably, the content is 0.1% by mass or more, even more preferably, 0.3% by mass or more, and particularly preferably It is preferably 0.5 mass % or more. The total content of the component (C) is preferably 30% by mass or more based on the total amount of the composition for external use on skin. More preferably, the content is 20% by mass or less, even more preferably, 15% by mass or less, and even more preferably, Or, it is 10 mass % or less. The total content of the component (C) is preferably 0.001 to 100% by weight based on the total amount of the composition for external use on skin. 30% by mass, more preferably 0.01 to 20% by mass, and even more preferably 0. It is preferably 0.1 to 15% by mass, more preferably 0.3 to 10% by mass, and particularly preferably The content is usually 0.5 to 10 mass %.

[0064] The content of phenoxyethanol in the component (C) is not particularly limited, and the effect of the present invention is not affected. From the viewpoint of significantly exhibiting the above-mentioned effects, the amount of the composition for external use on the skin is preferably 0.001 to 5 mass % based on the total amount of the composition for external use on the skin. %, more preferably 0.01 to 3 mass%, even more preferably 0.05 to 2 mass%, and even more preferably It is more preferably 0.1 to 1% by mass. The content of dipropylene glycol in the component (C) is not particularly limited, and the effectiveness of the present invention is not affected. From the viewpoint of exhibiting a remarkable effect, the amount of the composition for external use on skin is preferably 0.01 to 20 % by mass, more preferably 0.1 to 15% by mass, even more preferably 0.5 to 12% by mass, The content is more preferably 1 to 10% by mass. The content of the amphiphilic component in the component (C) is not particularly limited, and the effect of the present invention is not significantly improved. From the viewpoint of the above, the amount of the composition for external use on skin is preferably 0.001 to 20% by mass based on the total amount of the composition for external use on skin. The content is preferably 0.01 to 15 mass %, and more preferably 0.1 to 10 mass %. % by mass, and even more preferably 0.5 to 8% by mass. Among the amphiphilic components of component (C), divalent carboxylate and / or alkyleneoxy The content of the amide derivative is not particularly limited, and from the viewpoint of exhibiting the effects of the present invention remarkably, The amount of the composition is preferably 0.01 to 20% by mass, more preferably 0.1 to 15% by mass. % by mass, more preferably 0.5 to 10% by mass, and even more preferably 0.5 to 8% by mass. do. Among the amphiphilic components of component (C), 2-methacryloyloxyethyl phosphorylcholine The content of the polymer contained is not particularly limited, and from the viewpoint of exhibiting the effects of the present invention remarkably, The content of the composition is preferably 0.001 to 1% by mass, more preferably 0.0 0.05 to 0.5 mass%, more preferably 0.01 to 0.4 mass%, and even more preferably is 0.01 to 0.2 mass %. Among the amphiphilic components of the component (C), the content of the alkanediol having 5 to 10 carbon atoms is particularly From the viewpoint of significantly exhibiting the effects of the present invention, the composition for external use on skin is not limited to the above, and the amount of the composition for external use on skin is preferably Preferably, it is 0.01 to 20% by mass, more preferably, it is 0.05 to 15% by mass, and further preferably is 0.1 to 12 mass%, further preferably 0.5 to 10 mass%, particularly preferably 1 to 1 It is 0% by mass, and particularly preferably 1 to 5% by mass.

[0065] The total content of the component (C) relative to 1 part by mass of the total content of the component (B) in the composition for external use on the skin of the present invention The content is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.0 0.005 to 3000 parts by mass, more preferably 0.002 to 200 parts by mass, and further preferably 0 0.01 to 100 parts by mass, even more preferably 0.02 to 30 parts by mass, and particularly preferably 0. The content is 1 to 10% by mass.

[0066] [Other ingredients] In addition to the above-mentioned components (A) to (C), the composition for external use on the skin of the present invention has other useful effects. In addition, it has the effect of scattering ultraviolet rays, absorbing ultraviolet rays, and preventing and / or repairing DNA damage. ingredients, whitening ingredients, anti-inflammatory ingredients, antibacterial ingredients, germicidal ingredients, refreshing agents, organic acids, anti-glycation ingredients , cell activating ingredients, astringent ingredients, antioxidant ingredients, anti-aging ingredients, moisturizing ingredients, polyhydric alcohol, Skin softening ingredients, vitamins, blood circulation promoting ingredients, sebum absorbing ingredients, peptides or their derivatives, Various components such as amino acids or derivatives thereof may be blended singly or in combination of two or more kinds. These components can be used in the fields of medicines, quasi-drugs, cosmetics, etc. As long as it satisfies the above requirements, there is no particular limitation and any suitable one can be selected and used. Ingredients that fall under multiple categories can be added as ingredients with any of the above effects. Let us assume that.

[0067] Examples of the ultraviolet scattering agent include zinc oxide, titanium oxide, iron oxide, cerium oxide, Zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silica Inorganic compounds such as acids, and their derivatives such as hydrous silicic acid, aluminum hydroxide, mica, It is coated with inorganic powder such as talc, or is made of polyamide, polyethylene, polyester, polystyrene, etc. Compounds of resin powder such as olefin and nylon, as well as silicone oil and fatty acid aluminum Examples of the titanium oxide include those treated with zinc oxide, titanium oxide, and alkyl titanates. Inorganic compounds such as ferric oxide, phosphate, and aluminum hydroxide, It is preferable to use inorganic powder such as mica or talc, or a material coated with silicone oil. When blending, the content can be appropriately selected taking into consideration the feel on the skin and the effect. For example, about 0.001 to 35% by mass, preferably about 0.001 to 35% by mass, based on the total amount of the skin topical composition of the present invention. .1 to 25 mass%.

[0068] The ultraviolet absorbing agent is not limited, but is preferably a salicylic acid-based ultraviolet absorbing agent. agents, cinnamic acid-based UV absorbers, benzoylmethane-based UV absorbers, benzoic acid ester derivatives Body UV absorbers, triazine derivative UV absorbers, benzalmalonate derivative UV absorbers agents, octocrylene-based ultraviolet absorbers, imidazole sulfonic acid derivative ultraviolet absorbers, The ultraviolet absorber may be a zofenone derivative.

[0069] Examples of ultraviolet absorbers include 2-ethylhexyl salicylate and homomethyl salicylate. salicylic acid-based ultraviolet absorbers such as ethylene glycol salicylate; Glyceryl p-methoxycinnamate, mono-2-ethylhexanoate; 2-ethyl p-methoxycinnamate Cinnamic acid UV absorbers such as hexyl; 4-tert-butyl-4'-methoxydibenzo Benzoylmethane ultraviolet absorbers such as 2-[4-(diethylamino)-2- Benzoic acid ester derivatives such as hydroxybenzoyl benzoic acid hexyl ester UV absorbers Collector;Dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1 ,3,3-tetramethylbutyl)phenol];2,4-bis-[{4-(2-ethylhexyl) xyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1, 3,5-Triazine, diethylhexylbutamidotriazone, 2,4,6-tris[4- (2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine and other triazines Azine derivatives; benzalmalonate derivatives such as dimethicone diethyl benzalmalonate UV Radiation absorber; 2-Cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester Octocrylene UV absorbers such as ter; 2-phenylbenzimidazole-5-sulfone acid, imidazole sulfonate such as disodium phenyldibenzimidazole tetrasulfonate benzophenone derivative ultraviolet absorber; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy Dihydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, Dibenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone and the like.

[0070] In the present invention, such an ultraviolet absorbing agent is, but not limited to, paramethoxyphenyl. 2-Ethylhexyl cinnamate, 4-tert-butyl-4'-methoxydibenzoyl meth 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester Dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-ethylhexyl , 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1 ,3,3-tetramethylbutyl)phenol], 2,4-bis-[{4-(2-ethylhexyl) xyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1, 3,5-Triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl )Anilino]-1,3,5-triazine, dimethicone diethyl benzalmalonate, 2-cyclohexyl Ano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester, and 2-furan One or more selected from the group consisting of phenylbenzimidazole-5-sulfonic acid preferable.

[0071] The ultraviolet absorbing agent may be a commercially available product or may be synthesized.

[0072] Commercially available products include, but are not limited to, Parsol EHS (DSM Nutrition Japan), ESCALOL 587 (Ashland Japan) , EusolexOS (Merck), Parsol HMS (DSM Nutrition (manufactured by BASF), Uvinul MC80 (manufactured by BASF), Parsol MCX (DSM Nutrition Japan), Parsol 1789 (DSM Nutrition Japan) (manufactured by SHON Japan), Ubinal A Plus Granular, Soft Shade D H, Tinosorb M (manufactured by BASF), Milestab 360, Mixxim BB / 100, Tinosorb S (BASF), Uvasorb HEB, Vinal T150 (manufactured by BASF), Heliosun OTZ (O'Laughli DSM Nutrition Industries), Parsol SLX (DSM Nutrition (manufactured by DSM Nutrition Japan), Parsol 340 (manufactured by DSM Nutrition Japan), Esca Roll 597 (Ashland Japan), Parsol HS (DSM Nutrition (manufactured by J.P. Japan), Eusolex232 (manufactured by Merk), NeoHeliopan AP (made by Herman & Reimer), Ubinal M40, Escarole 567 Ashland Japan), Ubinal MS40 (BASF), SEESORB107 (Cipro Kasei), SEESORB100 (Shipro Kasei), SEESORB106 (Shipro (manufactured by Kasei Co., Ltd.)

[0073] In the composition for external use on the skin of the present invention, the total content of the ultraviolet absorbing agent is , preferably 1% by mass or more, more preferably 3% by mass or more, and even more preferably 6% by mass or more. More preferably, the total content of the ultraviolet absorbing agent is 7% by mass or more. Based on the total amount, it is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably The total content of the ultraviolet absorber is 10 mass % or less based on the total amount of the composition. Preferably, it is 1 to 20 mass%, more preferably, it is 3 to 15 mass%, and further preferably, it is 5 to 10 mass%. % by mass, and even more preferably 7 to 10% by mass.

[0074] In the skin topical composition of the present invention, the ratio of the total content of the ultraviolet absorber to the component (B) is not particularly limited, but the amount of the ultraviolet absorber is preferably 0.05 to 1 part by mass of the (B) component. 0.1 to 20 parts by mass, more preferably 0.1 to 15 parts by mass, and even more preferably 0.1 to 10 parts by mass. parts by mass, even more preferably 0.1 to 6 parts by mass, particularly preferably 0.5 to 4 parts by mass, and particularly preferably It is more preferably 1 to 2 parts by mass. In the skin topical composition of the present invention, the component (B) is a vitamin C derivative and tranexamic acid. When the compound is one or more selected from the group consisting of the above, it has a high ultraviolet absorption rate against the component (B). The ratio of the total content of the ultraviolet absorbing agent is not particularly limited, but is preferably 1 part by mass of the (B) component. The agent is preferably 0.5 to 20 parts by mass, more preferably 1 to 18 parts by mass, and further preferably It is 2 to 15 parts by mass, and even more preferably 5 to 10 parts by mass.

[0075] In addition, these UV scattering agents and UV absorbing agents can be compounded, supported, or encapsulated with other components. The combination of these is not particularly limited.

[0076] Examples of components having an effect of preventing and / or repairing DNA damage include those for animals (e.g. , Artemia); components derived from plants (e.g., Cat's Claw); DN A, DNA salts, RNA, RNA salts, and other nucleic acid components. Prevention of DNA damage and / or The content of the ingredient having a repairing effect can be appropriately selected taking into consideration the feel and effect on the skin. However, the amount of the composition for external use on the skin of the present invention is, for example, about 0.001 to 3% by mass, preferably In general, the content is about 0.01 to 1% by mass. When animal or plant ingredients are used, the content is In terms of extracts such as dandelions, the amount is preferably about 0.0 The content is 0001 to 0.1% by mass, and more preferably about 0.0001 to 0.01% by mass.

[0077] Examples of whitening ingredients include placenta, kojic acid, ellagic acid, phytic acid, and rusinolic acid. ole; chamomilla ET; hydroquinone, potassium 4-methoxysalicylic acid; linoleic acid and and its derivatives; ascorbic acid and its salts, vitamin C, pantothenic acid and its derivatives Vitamins such as butyl alcohol, etc. In addition, plant ingredients with whitening properties are included. It may be used as a skin-whitening ingredient. Examples of such plant ingredients include iris (Iris), almond. aloe, acerola, oolong tea, scutellaria, goldfish, silverleaf, hypericum, Dolichosoma, seaweed, pueraria lobata, gardenia, lily of the valley, chlorella, rice, rice hyphae, oryza Nol, rice bran, sausage, pepper, perilla, peony, cnidium, sophora gracilis , soybean, natto, tea, angelica, calendula, witch hazel, safflower, peony root, yoku Insect, acacia, kiwi, black bean, gentian, gentian root, sage, radish, Azalea, parsley, holly, hops, thyme, clove, tangerine, licorice, chamomile, Loon, meadowsweet, barberry, hawkweed, grapefruit, thorny pear, lemon pine, neem, artichoke, horsetail, bark, evening primrose, bilberry , Geranium, Salicornia, White willow, Saxifrage, Centella asiatica, Rosemary These include ingredients derived from lavender, devil's claw, and Cornus officinalis. When a plant component is used in the skin topical composition of the present invention, the form of the plant component is not particularly limited. In general, the plant extract or essential oil can be used. The names in parentheses for the plant ingredients listed above are the scientific name, alternative name or herbal medicine name of the plant.

[0078] In the present invention, such a whitening component is not particularly limited, but may be, for example, placenta; Kojic Acid; Ellagic Acid; Phytic Acid; Rucinol; Chamomilla ET; Hydroquinone; 4-Methoxypropanediol; Toxic salicylic acid potassium salt; Linoleic acid and its derivatives; Ascorbic acid, Ascorbic acid Sodium phosphate; Iris, almond, aloe, acerola, radish, scutellaria, ouran , Hypericum, Lamium, Seaweed, Pueraria lobata, Chlorella, Rice, Rice hyacinth, Oleander Zanol, rice bran, perilla, peony, mulberry, soybean, tea, calendula, hawthorn Mamelis, Peony, Coix seed, Kiwi, Sage, Parsley, Holly, Hops, Thyme , clove, tangerine, licorice, chamomile, prune, meadowsweet, barberry, Sowberry, grapefruit, pear, lemon, pine, neem, artichoke, spinach Ginger, bark, evening primrose, bilberry, geranium, glasswort, and common ginger. Willow, Saxifrage, Centella, Rosemary, Lavender, Devil's Claw, and Sa Preferably, the extract is one or more selected from the group consisting of extracts extracted from Chinese quince, Placenta; Kojic acid; Phytic acid; Hydroquinone; Ascorbic acid, Ascorbic acid Sodium stearate; Iris root extract, Almond oil, Aloe vera extract, Acerola extract, E Ijitsu extract, Scutellaria root extract, Hypericum extract, Lamium extract, Seaweed extract , Kakkon extract, Chamomile extract, Peony extract, Soybean extract tea extract, white tea extract, calendula, witch hazel, coix seed extract, ha Tears extract, hop extract, prune extract, licorice extract, oil-soluble licorice extract , Meadowsweet Extract, Purple Bark Extract, Alpinia Katsumadai Seed Extract, pear fruit extract, rose extract, lemon extract, kiwi extract, pine extract, Neem leaf extract, artichoke extract, horsetail extract, bark extract, citronella extract Gusa extract, evening primrose oil, bilberry leaf extract, geranium extract, glasswort extract, White Willow Extract, Centella Asiatica Extract, Harpagophytum Root Extract, and Sanshu It is more preferable to use one or more extracts selected from the group consisting of:

[0079] When the skin external composition of the present invention is blended with the above-described whitening ingredient, the content of the ingredient is The amount of the composition for external use on the skin can be appropriately selected taking into consideration the feel and effect on the skin. The concentration of the plant extract is about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. When using, the content is calculated as the extract, etc., based on the total amount of the skin topical composition. For example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, more preferably about 0.0001 to 20% by mass. The content is more preferably 0.001 to 10% by mass.

[0080] Examples of anti-inflammatory ingredients include allantoin, calamine, glycyrrhizic acid, or the like. Derivatives or their salts (e.g., dipotassium glycyrrhizinate, monopotassium glycyrrhizinate, ammonium, etc.), glycyrrhetinic acid or its derivatives or their salts (e.g., glycyrrhetinic acid, ricyrrhetic acid, stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, Zulene and its derivatives (e.g., guaiazulene, azulene, etc.), tocopherol acetate , pyridoxine hydrochloride, menthol, camphor, turpentine, indomethacin, salicylic acid or its derivatives, steroids or their derivatives or their salts (e.g., hydrocortisone, Tizone, prednisolone), ufenamate, bufexamac, ibuprofen picono Derived from plants (e.g. comfrey, coptis japonica, dokudami) Preferred are allantoin, dipotassium glycyrrhizinate, and glyceryl stearate. Monoammonium ricyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, a One selected from the group consisting of minocaproic acid, azulene and its derivatives, and Houttuynia cordata extract More preferably, allantoin, dipotassium glycyrrhizinate, One or more selected from the group consisting of glycyrrhetinic acid and aminocaproic acid. When anti-inflammatory ingredients are included, their content should be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0003 to 10 mass % of the total amount of the composition for external use on the skin of the present invention can be selected. % by mass, preferably about 0.01 to 5% by mass.

[0081] Examples of antibacterial or bactericidal components include chlorhexidine, salicylic acid, and benzaldehyde chloride. Ruthenium, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropyl methylpheno ol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, Phenoxyethanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, chloride Cetyltrimethylammonium, piroctoolamine, zinc pyrithione, miconazole or its salts, chlorobutanol, glyceryl caprylate, ethylhexylglycerin, Propynyl iodide butylcarbamate, caprylhydroxamic acid, phenethyl alcohol , methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, azelaic acid, plant ( For example, ingredients derived from sophora flavescens, rosemary, mulberry, eucalyptus, etc. may be mentioned. Among them, salicylic acid, benzalkonium chloride, ethanol, cetylpyridinium chloride, Cetyltrimethylammonium chloride, gluconic acid, isopropyl methylphenol, para Ben, phenoxyethanol, cetylpyridinium chloride, zinc pyrithione, chlorobutadiene Alcohol, Ethylhexylglycerin, Iodopropynyl Butylcarbamate, Caprylyl Doloxamic acid, sorbic acid, beta-glycyrrhetinic acid, rosemary extract, and eucalyptus It is preferable to use one or more extracts selected from the group consisting of extracts of When the composition is mixed with the skin, the content of the composition can be appropriately selected in consideration of the feel and effect on the skin. For example, about 0.0003 to 10% by mass, preferably about It is about 0.001 to 5 mass %.

[0082] Examples of the cooling agent include menthol and its derivatives, camphor, borneol, and gelatin. Terpenes such as raniol, cineole, anethole, limonene, and eugenol (these may be in the d-, l- or dl-form; eucalyptus oil, bergamot oil, peppermint oil Mint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose Among them, l-menthol, menthyl glyceryl ether, and essential oils such as turpentine oil are particularly preferred. ether, menthyl lactate, menthyl 3-hydroxybutyrate, menthoxypropanediol Combinations with oleic acid, camphor, eucalyptus oil, peppermint oil, and peppermint oil are preferred. When a cosmetic agent is added, its content can be appropriately selected taking into consideration the feel and effect on the skin. For example, the amount is 0.001 to 5% by mass or more, preferably 0.001 to 5% by mass or more, based on the total amount of the composition for external use on skin of the present invention. The content is preferably 0.005 to 3 mass % or more, and more preferably 0.01 to 1 mass % or more.

[0083] Examples of the organic acid include gluconic acid, aspartic acid, and aminoethylsulfonic acid. , citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, Pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid , glutamic acid, azelaic acid, and salts thereof. Examples of salts include sulfate. salts of mineral acids such as hydrochloric acid or phosphoric acid; salts of organic acids such as maleic acid or methanesulfonic acid; Alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, basic Examples include amino acid salts and amine salts such as triethanolamine. Among these, gluconic acid , Citric acid, Glutamic acid, Succinic acid, Malic acid, Salicylic acid, Glycolic acid, Phytin Preferably, one or more selected from the group consisting of glycyrrhetinic acid, tartaric acid, lactic acid, and glycyrrhetinic acid. This is more preferable.

[0084] Examples of anti-glycation ingredients include Budreja axillaris leaf extract, plum fruit extract, and E. -Delweiss extract, ginkgo extract, cherry leaf extract, pomegranate extract, osmanthus major Coextract, Hawthorn extract, Peony extract, Houttuynia cordata extract, Bilberry leaf Extract, green tea extract, black tea extract, horse chestnut extract, Roman chamomile extract, mugwort extract Plant extracts such as ginger, evening primrose oil, amla fruit, fruit juice or their extracts, L-arginine Examples of such fatty acids include glycerin, L-lysine, hydrolyzed casein, hydrolyzable tannins, and carnosine. When anti-glycation ingredients are included, their content can be appropriately selected taking into consideration the feel and effect on the skin. However, for example, about 0.0003 to 10% by mass based on the total amount of the skin external composition of the present invention. , and preferably about 0.001 to 5 mass %.

[0085] Examples of cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid. Acids: Retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, pyrophosphate Vitamins such as quinolinones; gluconic acid, phytic acid, glycolic acid, lactic acid, etc. α-hydroxy acids; tannins, flavonoids, saponins, allantoin, placenta ta, proteoglycan, photosensitizer No. 301, plants (e.g., soybean, bilberry, lemon) Grass, aloe vera, chlorella, bellflower, coix seed, chamomile, Houttuynia cordata, hops, Ingredients derived from carrots, etc.; Royal jelly, royal jelly extract; whey, yogurt Examples include whey-derived extracts such as gluten extract, hydrolyzed milk protein, and yeast extract. When cell activation ingredients are included, the amount of each ingredient should be selected appropriately, taking into consideration the skin feel and effects. However, for example, about 0.0003 to 10 mass % of the total amount of the skin external composition of the present invention. %, and preferably about 0.001 to 5 mass %.

[0086] Examples of astringent ingredients include alum, chlorohydroxyaluminum, and aluminum chloride. nium, aluminum allantoin, zinc paraphenolsulfonate, zinc sulfate, sulfate Metal salts such as aluminum potassium and basic aluminum zinc lactate; tannic acid, citric acid , organic acids such as lactic acid and succinic acid, plants (e.g. seaweed, thyme, black tea, oolong tea, green tea, Hypericum, Hamamelis, Loquat, Peony, Saxifrage, Rooibos, Rengesu, Ardisia crenata Tea choke, chamomile, eucalyptus, lemon, rosemary, burnet, etc.) When astringent ingredients are used, their content is determined based on the feel and effect on the skin. It can be appropriately selected taking into consideration the above, but it may be, for example, about 0. The content is 0.003 to 20% by mass, and preferably about 0.01 to 10% by mass.

[0087] Examples of the antioxidant include butyl hydroxyanisole and dibutyl hydroxytoluene. Ene, sodium hydrogen sulfite, sodium pyrosulfite, erythorbic acid and its salts, aspartame Corbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, Glutathione-S-transferase, catalase, superoxide dismutase , thioredoxin, taurine, thiotaurine, hypotaurine, plants (e.g. Hypericum perforatum , Kakkon, bilberry, Scutellaria, Passiflora edulis, grapefruit, peony Medicago sativa, Meadowsweet, Shiso, Honeysuckle, Sage, Yarrow, Mallow, Motsukesou, malva serrata, clove, chinpi, dwarf geranium, loquat, safflower, peonies, Hops, eucalyptus, saxifrage, rooibos, lemongrass, soybean, mugwort, nightshade These include ingredients derived from herbs, rosemary, lavender, etc. When the composition is mixed with the skin, the content of the composition can be appropriately selected in consideration of the feel and effect on the skin. For example, about 0.00001 to 10% by mass, preferably about 0.00001 to 10% by mass, based on the total amount of the composition for external use on the skin. The content is 0.0001 to 5% by mass, and more preferably 0.001 to 5% by mass.

[0088] Anti-aging ingredients include, for example, hydrolyzed soy protein, retinoids (retinol, tinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingomyelin Syn derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (Caprooyl tetrapeptide-3, oligopeptide-24, etc.), plants (Artichoke , Rosa rugosa, seaweed, bilberry, birch, plantain, angelica, and ogo , Hypericum, Comfrey, Neem, Wild rose, Bellflower, Geranium, Tilia linden, Among them, hydrolyzed soy protein, retinol, retinol acetate, etc. ole, retinol palmitate, caprooyl tetrapeptide-3, oligopeptide-24 , artichoke leaf extract, seaweed extract, bilberry leaf extract, comfrey leaf extract, Neem leaf extract and Geranium globulus extract are preferred. If anti-aging ingredients are included, their content The amount of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. It is.

[0089] Moisturizing ingredients include, for example, alanine, serine, aspartic acid, glycine, and proline. , hydroxyproline, glucosamine, theanine, arginine, and other amino acids and their derivatives Conductors: polyhydric alkoxides such as glycerin, 1,3-propanediol, and 1,3-butanediol chol; sorbitol, xylitol, erythritol, maltose-sucrose condensates (glucose sugars such as xyloligosaccharides, hydrolyzed xylan (xylooligosaccharides), and glyceryl glucoside Alcohol; glycosyltrehalose, trehalose; ceramide, glucosylceramide, Cholesterol, phytosterol, cholesterol derivatives, phytosterol derivatives, Phospholipids such as lecithin and hydrogenated lecithin; Lactic acid, sodium lactate, pyrrolidone carbo NMF-derived ingredients such as sodium phosphate and urea; hyaluronic acid (hydrolyzed hyaluronic acid, low hyaluronic acid, etc.); salts of hyaluronic acid (e.g., sodium hyaluronate, hyaluronic acid, etc.) Zinc hyaluronate, low molecular weight zinc hyaluronate, etc.); hyaluronic acid derivatives (acetylated hyaluronate) acetylated hyaluronic acid or its salts (e.g., sodium acetylated hyaluronate, acetylated hyaluronate, Zinc hyaluronic acid, etc.), cross-linked hyaluronic acid derivatives (sodium hyaluronic acid crosspolymer, etc.), carbo Sodium hydroxymethyl hyaluronate, unsaturated hyaluronic acid or its salt, hydrolyzed hyaluronic acid Alkyl (C12-13) glyceryl, cationic hyaluronic acid derivative (hyaluronic acid hydride) hydroxypropyltrimonium, etc.); hyaluronic acid dimethylsilanol, etc.); chondroitin Chondroitin sulfate or its salts (sodium chondroitin sulfate, potassium chondroitin sulfate, delta sodium dermatan sulfate, potassium dermatan sulfate, etc.); heparinoids, collagen, Elastin, keratin, chitin, chitosan, etc. and their hydrolysates; hydroxyethyl Rare; plants (e.g., aloe, seaweed, pueraria lobata, chlorella, lemongrass, chamomile, Ingredients derived from Hamamelis, tea, perilla, grapefruit, Gynostemma pentaphyllum, etc. Among them, glycine, arginine, glycerin, 1,3-propanediol, 1,3-butanediol, glycosyltrehalose, ceramide, glucosylceramide, co Lecithin, cholesterol derivatives, phytosterol derivatives, hydrogenated lecithin, milk Acid, sodium lactate, sodium pyrrolidone carboxylate, urea, hydrolyzed hyaluronic acid, Low molecular weight hyaluronic acid, sodium hyaluronate, zinc hyaluronate, low molecular weight hyaluronic acid Zinc, acetylated hyaluronic acid, sodium hyaluronic acid crosspolymer, hyaluronic acid hydrochloride Xypropyltrimonium, dimethylsilanol hyaluronate, collagen, elastin , keratin, hydroxyethyl urea, seaweed extract, chamomile extract, witch hazel extract In the case where a moisturizing component is blended, one or more kinds selected from Gynostemma pentaphyllum extract are preferable. In this case, the content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 20% by mass, preferably about 0.01 ~10% by mass.

[0090] Examples of polyhydric alcohols include diols having 2 to 4 carbon atoms or 11 or more carbon atoms, hydroxy Examples of suitable polyhydric alcohols include polyhydric alcohols having three or more groups, such as glycerin, diglycerin, triglycerin, etc. Diglycerin, propylene glycol, 1,3-butanediol, 1,3-propanediol ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol Among them are glycerin, diglycerin, propylene glycol, 1,3-propanediol, 1,3-butylene glycol A combination of two or more types is preferred. When polyhydric alcohol is used, its content The amount of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel on the skin and the moisturizing effect. For example, about 0.1 to 20% by mass, preferably about 0.5 to 15% by mass, based on the total amount. do.

[0091] Examples of keratin softening ingredients include adipic acid, lanolin, urea, phytic acid, lactic acid, and milk. Acid salts, glycolic acid, salicylic acid, malic acid, citric acid, fruit acids, phytic acid, urea , sulfur, etc. Among them, lactic acid, sodium lactate, glycolic acid, salicylic acid, A combination of phytic acid and citric acid is preferred. When a keratin softening ingredient is used, its content The amount of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel and effect on the skin. For example, 0.0001 to 50% by mass, preferably about 0.001 to 50% by mass , and more preferably about 0.01 to 25% by mass.

[0092] Vitamins include, for example, retinol, retinol acetate, and retinol palmitate. , retinol derivatives such as retinol propionate and retinol linoleate, retinal, Retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d -δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate Vitamin A derivatives such as thiocyanate; β-carotene, α-carotene, γ-carotene, δ-carotene Provitamin A, such as lycopene, zeaxanthin, cryptoxanthin, and echinenone ; δ-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol dl-α-tocopherol calcium succinate, tocopherol nicotinate, dl- Alpha-tocopherol, tocopherol linoleate, tocopherol (linoleate / oleate) Vitamin E, such as glycerol; γ-oryzanol, thiamine, and their salts (e.g., dibenzyl Vitamin B1 such as benzoylthiamine hydrochloride, thiamine hydrochloride, and thiamine diphosphate; Riboflavin, Flavin mononucleotide, Flavin adenine dinucleotide, Riboflavin Riboflavin butyrate, Riboflavin tetrabutyrate, Riboflavin 5'-phosphate Vitamin B12, such as sodium tetrahydrocanthate, riboflavin tetranicotinate, and their salts Category 2: Benzyl nicotinate, methyl nicotinate, nicotinic acid, and other ingredients other than those listed in (A) above Nicotinic acid; ascorbic acid, sodium ascorbate and other vitamin C; methyl heptagonists; Vitamin D derivatives such as speridine, ergocalciferol, and cholecalciferol; Vitamin K such as roquinone and farnoquinone; pyridoxine hydrochloride, pyridoxine acetate, salt Vitamin B6 such as pyridoxal acid, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride Vitamins such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin Vitamin B12; folic acid, pteroylglutamic acid and other folic acids; pantothenic acid, pantothenic acid Calcium, pantothenyl alcohol (panthenol), D-pantetheine, D-pante tin, coenzyme A, pantothenyl ethyl ether, calcium pantetheine sulfonate, etc. Pantothenic acid; biotin, biocytin, and other biotins; carnitine, ferulic acid, etc. Lipoic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, hesperidin Vitamin-like factors such as glucosyl hesperidin, ubiquinone, and their salts Among them are vitamin B, vitamin C, vitamin E, vitamin A, vitamin Combinations with amine-like agents are preferred, particularly pyridoxine hydrochloride, pantothenyl alcohol, etc. Panthenol, Riboflavin, Cyanocobalamin, Ascorbic Acid, Acetate dl- α-Tocopherol, Retinol, Retinol Palmitate, Retinol Propionate, Retinol acetate, pyrroloquinoline quinone or its salt, ubiquinone, and gamma-oryzanol It is more preferable to use one or more selected from the group consisting of: The content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 30 mass%, preferably about 0.01 to 25 mass%, based on the total amount of the % by mass, and more preferably about 0.01 to 20% by mass.

[0093] Examples of blood circulation promoting ingredients include plants (e.g., ginseng, angelica tree, arnica, etc.) , ginkgo, fennel, laurel, Dutch oak, chamomile, Roman chamomile, Rotthorn, gentian, burdock, rice, hawthorn, shiitake mushroom, ginger, and oak Chinese laurel, Juniperus communis, Cnidium rhizome, Swertia japonica, Thyme, Clove, Chinese chimpanzee, Japanese angelica, Japanese toad Nin, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, Melissa, yuzu, coix seed, rosemary, rosehip, peach, apricot, walnut, tomato Ingredients derived from corn; dl-α-tocopherol acetate, tocopherol nicotinate Glucosyl hesperidin, hesperidin, caffeine, capsicum tincture, gamma Oryzanol, capsaicin, nicotinic acid benzyl ester, etc. When a component is added, its content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.00001 to 10% by mass, preferably about 0.00001 to 10% by mass, based on the total amount of the composition for external use on skin of the present invention. The content is preferably 0.0001 to 5% by mass, and more preferably about 0.001 to 5% by mass. When using ingredients derived from natural products, the content is calculated based on the total amount of the skin topical composition. For example, about 0.00001 to 20 mass%, preferably about 0.0001 to 15 % by mass, and more preferably 0.001 to 10% by mass.

[0094] Examples of sebum-absorbing components include talc, mica, hydroxyapatite, zinc oxide, Among them, mica, hydroxyapatite, and the like are preferable. In the case where a sebum-absorbing component is blended, the preferred is mica. In this case, the content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 35% by mass, preferably about 0.1 to 35% by mass, based on the total amount of the composition. It is 25% by mass.

[0095] Examples of the above peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, Chin, collagen, fish collagen, atelocollagen, succinylated atelocollagen gelatin, elastin, elastin decomposition peptides, collagen decomposition peptides, hydrolyzed Hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, Elastin Degraded peptides, conchiolin decomposition peptides, hydrolyzed conchiolin, silk protein decomposition peptides , hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein hydrolyzed peptide, Hydrolyzed soy protein, wheat protein, wheat protein hydrolyzed peptide, hydrolyzed wheat protein, casein hydrolyzed peptide Peptides, acylated peptides (palmitoyl oligopeptides, palmitoyl pentapeptides) , palmitoyl tetrapeptide, etc.) are included. Among them, keratin hydrolysis peptide, hydrolyzed peptide, etc. Decomposed keratin, fish-derived collagen elastin, elastin decomposition peptide, collagen decomposition Peptides, hydrolyzed collagen, succinylated atelocollagen, elastin hydrolyzed peptides The hydrolyzed soy protein is selected from the group consisting of hydrolyzed silk, hydrolyzed soy protein, and hydrolyzed soy protein. It is more preferable to combine one or more of the peptides or their derivatives. In the case of using the skin care product, the content of the skin care product can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0001 to 35% by mass, preferably about 0. It is .001 to 10 mass%.

[0096] Examples of the amino acids or derivatives thereof include betaine (trimethylglycine), Proline, Hydroxyproline, Arginine, Lysine, Serine, Glycine, Alanine, Phenolic Acid Nitralanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, Aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine , histidine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β- Hydroxybutyric acid, carnitine, carnosine, creatine, epsilon aminocaproic acid, Tryptophan, Ornithine, Di(phytosteryl / octyldodecyl) lauroyl glutamate syl), lauroyl glutamate di(octyldodecyl / phytosteryl / behenyl), etc. In addition, these amino acids or derivatives thereof may be in the form of solvates such as hydrates. In particular, amino acids in the l-form and their derivatives are preferred. It is preferable to use one or more selected from the group consisting of:

[0097] In addition to the components (A) to (C), the skin topical composition of the present invention may further contain the above-mentioned components. Depending on the purpose or dosage form, it is usually used in the fields of medicines, quasi-drugs, cosmetics, etc. The ingredients that can be blended are not particularly limited, but examples include , base or carrier, surfactant, thickener, antioxidant, preservative, pH adjuster, sharpness Additives such as thickeners, stabilizers, irritation reducers, colorants, dispersants, and fragrances can be added. These ingredients may be used alone or in any combination of two or more. The content of these components can be adjusted within the ranges known in the art without impairing the effects of the present invention. Furthermore, if the following multiple components are applicable, It can be added as an ingredient for any of the functions.

[0098] The base or carrier may be an aqueous base such as water; liquid paraffin, liquid isoparaffin, or sucrose. Quaran, Vaseline, Paraffin, Microcrystalline Wax, Polybutene, Polyethylene Ethylene powder, gelling hydrocarbons (Plastibase, etc.), ozokerite, α-olefin oligomer Hydrocarbons such as methyl polysiloxane, light liquid paraffin, and light iso-liquid paraffin; methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone , alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, poly Polyether modified silicone, Polyglycerin modified silicone, Crosslinked polyether modified silicone Silicone, crosslinked alkyl polyether modified silicone, silicone / alkyl chain co-modified Polyether modified silicone, silicone / alkyl chain co-modified polyglycerin modified silicone Polyether modified branched silicone, polyglycerin modified branched silicone, acrylic Silicone oils such as silicones, phenyl modified silicones, silicone resins; Setano , cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyl Dodecanol, isostearyl alcohol, phytosterols, cholesterol Higher alcohols; isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid Higher fatty acids such as phosphoric acid and behenic acid; ethyl cellulose, hydroxypropyl cellulose cellulose derivatives such as hydroxypropyl methylcellulose; polyvinylpyrrolidone; rolidone;polyvinyl butyrate;polyethylene glycol;dioxane;butylene glycol Coal adipate polyester; isopropyl myristate, octyldodecyl myristate Cetyl, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, tetraethyl Pentaerythritol, 2-ethylhexanoate, diisopropyl adipate, dioleate oleic acid isodecyl, dimethyloctanoic acid hexyldecyl, sebacate diisopropyl propyl, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, palmitate 2-Hexyldecyl Cocoate, Diisopropyl Adipate, Isotridecyl Isononanoate, Cetyl lactate, isostearyl isostearate, cholesterol 12-hydroxystearate Cholesteryl stearate, cholesteryl oleate, macadamia nut fatty acid Phytosteryl, oleic acid phytosteryl, palmitic acid dextrin, stearate isopropyl Nuline, hydrogenated jojoba oil, di-2-ethylhexyl ethylene glycol, dipentaerythritol Lithritol fatty acid ester, neopentyl glycol dicaprate, tri-trimellitic acid 2-Ethylhexyl, Tritridecyl Trimellitate, Tri-2-ethylhexyl Trimellitate Tyrolpropane, Trimethylolpropane Triisostearate, Tetra-2-ethyl Pentaerythritol hexanoate, glycerin tri-2-ethylhexanoate, triisosulfate Trimethylolpropane Thearate, Caprylic / Capric Triglyceride, Tri Caprylic / Capric / Myristic / Stearic Glyceryl Oleate Lauroyl glutamate, di(phytosteryl / octyldodecyl), lauroyl glutamate Di(octyldodecyl / phytosteryl / behenyl) glutamate, triethyl citrate, Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl Dimer dilinoleyl, dimer dilinoleate, dimer trihydroxystearic acid Pentaerythrityl, Tri(behenate / isostearate / eicosanedioate)glyceryl Esters such as jojoba oil, bean wax, candelilla wax, rice bran wax, cotton wax, Waxes such as lunauba wax and lanolin; avocado oil, linseed oil, camellia oil, macadamia nut oil Corn oil, olive oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil Oil, grape seed oil, sunflower oil, almond oil, shea butter, camellia oil, rapeseed oil, sesame oil , cocoa butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, Japanese laurel kernel oil, Japanese laurel, small Wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, and other oils and fats ;Polysaccharides such as dextrin and maltodextrin;Carboxyvinyl polymers, alkanols Vinyl polymers such as carboxyvinyl polymers modified with alkane; ethanol, isopropanol Lower alcohols such as sorbitol, xylitol, erythritol, mannitol, and sugar alcohols such as ethanol; water, etc. The base or carrier selected from these ingredients is The amount of each of these used may be determined by the following formula: The composition for external use on the skin of the present invention may be appropriately selected from the range known to those skilled in the art. The content of and the amount of water vary depending on the form of the cosmetic preparation, and are not particularly limited. For example, the amount of water is preferably 5 to 99%, more preferably , 8 to 95%, and even more preferably 10 to 90%.

[0099] Examples of surfactants include sorbitan monoisostearate, sorbitan monostearate, Diglycerol sorbitan tetra-2-ethylhexyl ester, sorbitan monophosphate stearate, sorbitan monoisostearate, sorbitan monolaurate and olive oil Sorbitan fatty acid esters such as sorbitan fatty acid; polyoxyethylene monolaurate ( 20) Sorbitan, Polyoxyethylene Monolaurate (80) Sorbitan, Monostearate Polyoxyethylene (20) Sorbitan Phosphate, Polyoxyethylene (2 (0) Sorbitan, polyoxyethylene isostearate, etc. (20) Sorbitan, etc. Diethylene sorbitan fatty acid ester; glycerin monooleate, glycerin monoester glycerol fatty acid esters such as glycerol monomyristate and glycerol monomyristate; Glycerin alkyl groups such as tearyl glyceryl ether and monomyristyl glyceryl ether Diglyceryl ether; diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl Polyglycerides such as lyceryl decaisostearate and diglyceryl diisostearate fatty acid esters; propylene glycol fats such as propylene glycol monostearate Fatty acid esters; Polyoxyethylene hydrogenated castor oil 40, Polyoxyethylene hydrogenated castor oil Oil 50, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80, etc. hydrogenated castor oil derivatives; polyoxyethylene monococoyl glyceryl fatty acid and other polyoxyethylene Ethylene glycerin fatty acid esters; polyoxyethylene cetyl ether and other polyoxyethylenes Diethylene alkyl ether; Polyoxyethylene (20) Phytosterol, Polyoxyethylene Diethylene (30) phytosterol, Polyoxyethylene (25) phytostanol, Polyoxyethylene (30) Hydrogenated polyoxyethylene sterols such as cholestanol Sterols; Sucrose fatty acid esters; Polyoxyalkylene alkyl (or alkenyl) ) Ether sulfates, ether carboxylates, alkyl phosphate esters, N-acylamines Tauric acid salts, acylated taurates; amines such as stearylamine and oleylamine; poly Oxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxane Silica gels such as polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc. Lecithin, hydrogenated lecithin, saponin, sodium surfactin Examples of surfactants include naturally occurring surfactants such as cholesterol and bile acid.

[0100] Examples of thickening agents include gums (gellan gum, xanthan gum, sclerotium gum, etc.) Locust bean gum, biosaccharide gum, tamarind gum, quince seed, almond gum Labia gum, tara gum, guar gum, galactan, gum arabic, tragacanth gum, etc.) ;Carrageenan, curdlan, succinoglucan;Heparinoids;Alginates (A alginic acid, sodium alginate, propylene glycol alginate, etc.); agar (agaro gelatin, pectin, pullulan, mannan, polyvinyl alcohol, poly Vinyl-based materials such as vinylpyrrolidone, polyvinyl methyl ether, and carboxyvinyl polymer Thickeners, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxy Dimethylcellulose, Hydroxypropylcellulose, Hydroxypropylmethylcellulose cellulose, carboxymethyl cellulose, carboxyethyl cellulose, hydrophobized hydroxypropyl cellulose Cellulosic thickeners such as propyl methylcellulose, dextran, methacrylic acid Alkyl polyacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester Stel, Dimethyl Distearyl Ammonium Hectorite, Polyethylene Glycol, Clogol, (hydroxyethyl acrylate / sodium acryloyldimethyl taurate) copolymer Rimer, (Ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer Among them, xanthan gum, acrylic acid alkyl methacrylate copolymer, Hydroxyethyl cellulose, Hydroxypropyl cellulose, Hydroxypropyl methyl Cellulose, polyvinylpyrrolidone, carboxyvinyl polymer, dimethyl distearate Ammonium Hectorite, (Hydroxyethyl Acrylate / Acryloyldimethyl Ta (Acryloyldimethyltaurate / Vinylpyrrolidone) Copolymer, (Ammonium acryloyldimethyltaurate / Vinylpyrrolidone Dong copolymers are preferred.

[0101] Examples of the antioxidant include dibutylhydroxytoluene and butylhydroxyanisole. , sorbic acid, sodium sulfite, ascorbic acid, tocopherol, tocopherol derivatives, erythorbic acid, sodium erythorbate, L-cysteine ​​hydrochloride, coenzyme Ubiquinones such as Zyme Q10, lignans such as sesamin, curcumin, capsaicin, Angewol, resveratrol, anthocyanin, cyanidin, bilberry extract and Analogues or derivatives of these compounds are included.

[0102] Preservatives or antiseptics include, for example, benzoic acid, sodium benzoate, dehydroacetic acid, Sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate Pill, Butyl Parahydroxybenzoate, Ethyl Parahydroxybenzoate, Propyl Parahydroxybenzoate Pill, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, Chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, methylisothiazide Azolinone, iodopropynyl butylcarbamate, caprylhydroxamic acid, phenethyl alcohol, etc.

[0103] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, etc.), and citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (Potassium hydroxide, Sodium hydroxide, etc.), Potassium carbonate, Sodium bicarbonate, Diacid Carbon hydride, organic bases (arginine triethanolamine, diisopropanolamine, triethanolamine, isopropanolamine, etc.

[0104] Examples of chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediamine Disodium edetate (Japanese Pharmacopoeia, EDTA-2Na, etc.) , potassium salts, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc. Of these, sodium edetate is preferred.

[0105] Examples of the stabilizer include sodium polyacrylate and dibutylhydroxytoluene. , butyl hydroxyanisole, and the like.

[0106] Examples of irritation reducers include licorice extract and polyvinylpyrrolidone.

[0107] Colorants include pigment grade titanium oxide, zinc oxide, iron oxide, organic pigments, talc, sericite, etc. Examples of suitable mica include chromium oxide, mica, synthetic mica, chromium oxide, and gunjo.

[0108] Powders may also be added to improve the texture or to impart a makeup effect. Boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, poly methyl methacrylate and the like.

[0109] [viscosity] The viscosity (25°C) of the composition for external use on the skin of the present invention is within the range of 1 to 500,000 mPa·s. However, from the viewpoint of significantly exhibiting the effects of the present invention, it is preferable that the number of 500000 mPa·s, more preferably 3 to 300000 mPa·s, and even more preferably The viscosity is 5 to 200,000 mPa·s. The main factors affecting viscosity are the type and content of the thickener, which is an added ingredient. By appropriate selection, a skin topical composition having such a viscosity can be obtained.

[0110] In the present invention, the viscosity is measured according to the viscosity test method described in the 17th edition of the Japanese Pharmacopoeia. The measurement is performed using a single cylindrical rotational viscometer (Brookfield type viscometer) in accordance with the measurement method of this application. In this case, we used RB-80H (Toki Sangyo), and the rotor, rotation speed, and other conditions were selected according to the specifications of this machine. Measure the viscosity at 25°C according to the instruction manual. Instructions for the single cylinder rotational viscometer The single cylinder rotational viscometer rotates a cylinder in a liquid at a constant angular velocity. This is a viscometer that measures the torque of a viscometer. By determining the constant KB, the viscosity η of the liquid is calculated by the following formula. η=KB × T / ω η: Viscosity of the liquid (mPa s) KB: Equipment constant (rad / cm 3 ) ω: Angular velocity (rad / s) T: Torque acting on the cylindrical surface (10 -7 N m)

[0111] [pH] The composition for external application to the skin of the present invention may generally have a pH of 2.0 to 9.0. From the viewpoint of low irritation to the skin and mucous membranes, and good feel on the skin, a pH of 3. 0 to 8.5, more preferably pH 4.0 to 8.0, and even more preferably pH 4.5 to 7.5, Even more preferably, the pH is 5.0 to 7.5.

[0112] [Angular frequency value of sol-gel transition point in dynamic viscoelasticity] The angular frequency of the sol-gel transition point in the dynamic viscoelasticity of the composition for external use on the skin of the present invention is the storage This is the angular frequency ω at which the elastic modulus G' and the loss modulus G" are equal. For example, The dynamic viscoelasticity is measured using a MCR rheometer. 102 (manufactured by Anton Paar), and the measurement jig is PP25-SN31369 (d=1 mm), at 25°C, with an oscillation angle (γ) of 1%, and an angular frequency (ω) of 100 to 0. The range was measured to be 1 (rad / s).

[0113] The angular frequency (rad / s) of the sol-gel transition point of the skin external composition of the present invention is From the viewpoint of exhibiting a remarkable effect, the number is preferably 3 or more, more preferably 4 or more, and further preferably The higher the angular frequency of the sol-gel transition point, the slower the recovery speed becomes. When force is applied to the composition, it becomes more likely to exhibit viscous properties, making it easier to scoop the composition when in use. It is easy to apply, spreads easily, and blends well with the skin.

[0114] [How to improve usability] The present invention also relates to a method for improving the usage sensation of a topical skin composition containing (A) a hydrophobically modified polyether urethane. According to the present invention, the method comprises: (A) a hydrophobically modified polyether urethane; (B) a niobium-containing polyether urethane; Selected from the group consisting of cotinamide, vitamin C derivatives, arbutin and tranexamic acids By preparing a composition for external use on the skin containing one or more components that are capable of preventing hydrophobicity, It is possible to improve the feeling of use of a composition for external use on the skin that contains modified polyether urethane. Here, the improvement of the feeling of use means, for example, that the composition spreads more smoothly when applied to the skin. It refers to the condition improving, or becoming more compatible with the skin.

[0115] [Method of manufacturing the composition for external use on skin] The method for producing the composition for external use on the skin of the present invention is not particularly limited, and in addition to the above-mentioned components (A) to (C), The other ingredients mentioned above are appropriately selected and mixed, and emulsified as necessary in a conventional manner to produce the product. It can be constructed.

[0116] [Properties / Formulation] The form of the composition for external use on the skin of the present invention is not particularly limited, and may be liquid, fluid, or semi-solid. The formulation may be, for example, a liquid, a suspension, an emulsion, a cream, Milky lotion, ointment, gel, liniment, lotion, aerosol, non-woven fabric containing medicinal liquid It can be formulated as a sheet or stick soaked in water. Suitable formulations include creams, emulsions, ointments, gels, lotions, and sheets. Particularly preferred are emulsions, creams, gels, lotions, sheets, and sticks. When a product contains both an oily base and an aqueous base, such as a cream or ointment, it can be either a W / O type or an O / W type. However, from the viewpoint of ensuring a suitable thickening of the composition for external use on the skin of the present invention and from the viewpoint of feeling of use (stickiness, From the standpoint of ease of application, spreadability, moisturizing feeling, freshness, penetration feeling, etc., O / W types are more preferable.

[0117] The composition for external use on the skin of the present invention is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, Therefore, the preparation is preferably a homogeneous preparation that does not contain non-uniform particles such as gel particles.

[0118] [Usage] Specific uses of the composition for external use as a quasi-drug or cosmetic include, for example: Lotion, milky lotion, gel, cream, serum, sunscreen, pack, mask, hand cream, all-in-one gel, all-in-one cream, cosmetic wipes, Cosmetics for the scalp, mists, body lotions, and body creams Basic cosmetics such as face washes, hand soaps, makeup removers, body shampoos, Cleansing cosmetics such as shampoos, rinses, and treatments, BB creams, foundations, etc. Face makeup cosmetics such as lotions, makeup bases, lip balms, lip liners lip cosmetics such as lip gels; hair rinses, hair treatments, hair care products Conditioner, hair gel, hair mousse, hair mist, hair lotion, styling Among these, compositions for external use on the skin are particularly preferred. That is, the composition for external use of the present invention is preferably a skin care product for use as a medicine, a quasi-drug, or a cosmetic. The formulation of the skin external composition of the present invention is In addition, the following items are also included: usable bases or carriers, additives, and active ingredients, as well as their The preferred embodiments are the same as those of the topical composition of the present invention.

[0119] [container] The skin topical composition of the present invention is packed in a container of a shape and material appropriately selected according to the purpose and application of the composition. Specific examples of containers include spray types, bottles, etc. Toll type, tube type, jar type, dropper type, dispenser type, Examples of the composition for external application to the skin of the present invention include a stick type, a pouch bag, and a cheer pack. Due to the physical properties of the hydrophobic modified polyether urethane, even if it gels, it can be applied or sprayed. Taking advantage of the advantage of being able to do this smoothly, for example, preparations containing high concentrations of (B) ingredient or Even in the case of highly viscous preparations such as those containing hydrophobically modified polyether urethane, This allows for greater freedom in formulation design. Of course, it can be easily applied in a wide variety of containers such as sprays, bottles, tubes and dispensers. It becomes possible to use it.

[0120] The container materials are polyethylene terephthalate, polypropylene, polyethylene Polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin Examples of the material include plastic, polystyrene, glass, and metal (aluminum, etc.). The materials are coated with various coatings, taking into consideration strength, flexibility, weather resistance, and stability of the ingredients. These materials can be combined, for example by mixing, or laminated to form containers. The coating material can be epoxy resin, polyamide, etc. Among them, polypropylene, polyethylene (HDPE, LDP Ethylene vinyl alcohol resin, or metal (aluminum, etc.) may be used. is preferred.

[0121] [How to use, etc.] The skin topical composition of the present invention has the following effects: promoting blood circulation, anti-inflammatory, and anti-inflammatory properties due to the physiological activity of component (B). It is expected to have effects such as promoting mide synthesis, whitening, anti-wrinkle, and anti-aging, and is also used as a whitening agent and sunscreen. The topical skin composition of the present invention is useful as a multifunctional preparation including a moisturizing agent and a moisturizing agent. Depending on the dosage, it may be taken once or several times a day according to the known or customary dosage regimen. can be used. EXAMPLES

[0122] Next, the present invention will be described in detail with reference to examples and test examples. The present invention is not limited to the above examples.

[0123] [Raw materials used] The raw materials used in the following test examples and production examples are as follows. The values ​​in each table of the test examples The content of the ingredient itself is shown in the ingredient name (all units are mass%). The values ​​in each table indicate the amounts of the raw materials listed below. (PEG-240 / Decyltetradeceth-20 / HDI) copolymer: Adekanol G T700 Polyoxyethylene methyl glucoside (10E.O.): Macbiobride MG-10 E (manufactured by NOF Corporation) Polyoxypropylene methyl glucoside (10P.O.): Macbiobride MG-1 0P (NOF Corporation) Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl Ether (3 BO)(8E.O.)(5P.O.):WILBRIDE S-753(NOF Corporation Company) Polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P. O.): Unilube 50MB-26 (manufactured by NOF Corporation) 2-Methacryloyloxyethyl phosphorylcholine-Butyl methacrylate copolymer:L ipidure PMB-RT (NOF Corporation) Bisethoxydiglycol cyclohexanedicarboxylate: Neosolue aqul io (manufactured by Nippon Fine Chemical Co., Ltd.) Decaglyceryl (eicosandioate / tetradecanedioate): Neosolue-Aqua S (manufactured by Nippon Fine Chemical Co., Ltd.) Polyoxyethylene glyceryl ether (26E.O.): Brownon GL-26 (Blue (Manufactured by Mokkoyu Co., Ltd.) Diethoxyethyl succinate: CRODAMOL DES-LQ (CRODAMOL Japan Co., Ltd.) )Manufactured by

[0124] [Test Example 1. Comparison of angular frequency values ​​of sol-gel transition points of skin topical compositions 1] A sample having the composition shown in Table 1 was prepared. (Manufactured by Anton Paar), the measurement jig is PP25-SN31369 (d=1mm) Using the above, under the conditions of 25°C, oscillation angle (γ) = 1%, angular frequency (ω) = 100~0.1(r The angular frequency range of the sol-gel transition point was measured. The results of the evaluation based on the standard are shown in Table 1. The angular frequency value of the sol-gel transition point is 2.5 If the temperature is less than rad / s, the recovery rate of the drug product is high, and the drug product does not stretch or blend well, resulting in poor product quality. It was determined that the drug was not suitable. <Evaluation criteria for angular frequency of sol-gel transition point> × Angular frequency of sol-gel transition point (rad / s) less than 2.5 △ Angular frequency of sol-gel transition point (rad / s) 2.5 or more and less than 3 Sol-gel transition temperature angular frequency (rad / s) 3 to less than 6 ◎ Sol-gel transition temperature angular frequency (rad / s) 6 or higher

[0125] In addition, the appearance of the obtained preparation is observed, and the transparency of the preparation is judged according to the following criteria. The higher the transparency of the formulation, the greater the range of applications for various containers and specifications. The evaluation results are shown in Table 1. <Evaluation of formulation transparency> × The preparation is turbid and has low transparency. △: Slightly cloudy, but mostly transparent ○ Transparent appearance

[0126] [Table 1]

[0127] Hydrophobically modified polyether urethane (PEG-240 / Decyltetradeceth-20 / In the presence of the HDI copolymer, Comparative Examples 1-1 to 1-5 not containing nicotinamide The angular frequency of the sol-gel transition point of the hydrophobically modified polyether urethane was less than 3. In Examples 1-1 to 1-6, which contained nicotinamide and nicotinic acid amide, the average wavelengths were all 5 rad / s or more. The angular frequency was increased by more than three times by the addition of nicotinamide. From the above, in the coexistence of components (A) and (B), the angular frequency of the sol-gel transition point is The values ​​increased. All of the formulations in the examples were easy to scoop and had a good feel when used (spreadability and familiarity). It was a good formulation.

[0128] In addition, when Comparative Examples 1-1, 3, and 4 are compared with Examples 1-1, 3, and 4, the hydrophobic modified polyester Polyoxybutylene polyoxyethylene polyoxy as component (C) Propylene glyceryl ether (3B.O.) (8E.O.) (17P.O.) or poly Contains oxyethylene polypropylene butyl ether (17E.O.) (17P.O.) In this case, the inclusion of nicotinamide has the effect of eliminating the cloudy appearance of the preparation. Fruit was also seen.

[0129] [Test Example 2. Comparison of angular frequency values ​​of sol-gel transition points of skin topical compositions 2] Compositions for external use on the skin having the compositions shown in Tables 2 to 6 below were prepared. That is, the angular frequency value at the sol-gel transition point was measured, and the evaluation was performed according to the above-mentioned evaluation criteria. The appearance of the obtained preparation was also observed, and the transparency of the preparation was evaluated according to the above criteria. The results are shown in Tables 2 to 6.

[0130] [Table 2]

[0131] [Table 3]

[0132] [Table 4]

[0133] [Table 5]

[0134] [Table 6]

[0135] As in Test Example 1, the formulations of the examples containing at least the components (A) and (B) were In all cases, the angular frequency of the sol-gel transition point is 2.5 rad / s or higher, and the usability (elongation) -Familiarity) was good. In addition, when nicotinic acid amide was used as component (B), It has become clear that a skin composition for external use having a particularly high angular frequency value at the sol-gel transition point can be obtained. I did.

[0136] In addition, the skin topical compositions of the Examples in Tables 2 to 6 were stored at 60° C. for 1 week, and then the sol-gel transition was observed. The angular frequency of the transition point was measured and found to be largely unchanged from before and after storage. It was revealed that the effect was stably maintained during storage.

[0137] [Formulation example] Based on the formulations in Tables 7 to 45 below, skin topical compositions of the present invention (Formulation Examples 1 to 39) were prepared. Made.

[0138] [Table 7]

[0139] [Table 8]

[0140] [Table 9]

[0141] [Table 10]

[0142] [Table 11]

[0143] [Table 12]

[0144]

Table 13

[0145]

Table 14

[0146]

Table 15

[0147]

Table 16

[0148]

Table 17

[0149]

Table 18

[0150]

Table 19

[0151]

Table 20

[0152]

Table 21

[0153]

Table 22

[0154]

Table 23

[0155]

Table 24

[0156]

Table 25

[0157]

Table 26

[0158]

Table 27

[0159]

Table 28

[0160]

Table 29

[0161]

Table 30

[0162]

Table 31

[0163]

Table 32

[0164]

Table 33

[0165]

Table 34

[0166]

Table 35

[0167]

Table 36

[0168]

Table 37

[0169]

Table 38

[0170]

Table 39

[0171]

Table 40

[0172]

Table 41

[0173]

Table 42

[0174]

Table 43

[0175]

Table 44

[0176]

Table 45

Claims

1. A composition for topical application to the skin, comprising: (A) a hydrophobically modified polyether urethane, and (B) Tranexamic acid The composition for external application to the skin contains the above-mentioned component (B), and the content of the component (B) is 1 to 5 mass % based on the total amount of the composition for external application to the skin.

2. The composition for topical application to the skin according to claim 1, wherein the component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I): R 1 -{(O-R 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O) n -R 5 ] h} m (I) (In the ceremony R 1 represents a hydrocarbon group, R 2 and R 4 each independently represent an alkylene group having 2 to 4 carbon atoms, R 3 represents a hydrocarbon group which may have a urethane bond and which is linear, branched, or contains an aliphatic ring or an aromatic ring, R 5 represents a hydrocarbon group having a branched chain; m is an integer of 2 or more, h is an integer of 1 or more, k and n each independently represent an integer in the range of 0 to 1000, and k+n≧1.

3. A skin topical composition described in claim 1 or 2, further containing (C) one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol and amphiphilic components.

4. The composition for external use on the skin according to any one of claims 1 to 3, wherein the amphiphilic component of the component (C) is one or more selected from the group consisting of a 2-methacryloyloxyethyl phosphorylcholine-containing polymer, a divalent carboxylate ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (II): Z-[O-(AO) a (EO) b -(BO) c -H] n (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively, and are each independently 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different; When Z is a hydrogen atom, n is 1.