COMPUTER PROGRAM, METHOD, AND APPARATUS FOR DETERMINING MULTIPLE FUNCTIONAL OCULAR PARAMETERS - Patent application

Abstract

The present invention relates to a computer program that causes a system to execute a method, in particular a computer-implemented method, for determining a number of functional ocular parameters when the computer program is executed on a computer, said system comprising an optical system (3) with a display system (4) configured to project visual stimuli independently to a left and right eye of a subject, an eye-tracking system (5) configured to record the gaze directions (100) and pupil sizes (102) of the left and right eyes, and a computer-implemented method for controlling the optical system (3) and recording from the eye-tracking system (5). and a computer (2) configured to receive data obtained by performing a step of the method according to claim 1, wherein an afferent pupillary defect (APD), in particular a relative afferent pupillary defect (RAPD), is determined from a first trial session consisting of an array of a first type of stimuli presented to the left and right eyes of the subject using the display system (4), and a visual field (400) is determined from a second trial session consisting of an array of a second type of stimuli presented to the left and right eyes of the subject using the display system (4), and strabismus is also determined by determining one or more strabismus angles from the first and / or second trial sessions.

Description

[Technical field]

[0001] The present invention relates to a method for determining a plurality of functional ocular parameters, in particular a computer program which, when executed on a computer, causes a system to execute the computer-implemented method, and a neuro-ophthalmoscope configured to execute said method according to the invention. [Background technology]

[0002] Methods are known in the art for determining functional ocular parameters such as strabismus, relative afferent pupillary defect, and visual field.

[0003] Usually, the evaluation of these parameters requires various equipment and specialized medical personnel to perform the necessary tasks. Therefore, the time required for the estimation of these parameters increases. Therefore, the more parameters are to be determined from the subject, the higher the degree of compliance of the subject is required.

[0004] Furthermore, some methods for determining RAPDs, such as the swinging flashlight test, suffer from a high degree of variability in test results between repeated tests.

[0005] Therefore, there is a need for methods that are less complicated in terms of subject compliance and comprehension of the test, and in terms of implementation by practitioners.

[0006] Although virtual reality systems address some of the problems related to the user's vision, see for example US 2017 / 0290504 A1, methods for computer-aided diagnosis of functional eye parameters are still lacking.

[0007] United States Patent Publication (US) 2017 / 0007119 A1 teaches an optical system for determining various functional eye parameters of a person.

[0008] US 2011 / 0299034 A1 discloses an OCT-system configured to determine various functional ocular parameters and the analysis of B-scans recorded by the OCT-system from the eye in response to visual stimuli. [Prior art documents] [Patent documents]

[0009] [Patent Document 1] US Patent Publication No. 2017 / 0290504 A1 [Patent Document 2] US Patent Publication No. 2017 / 0007119 A1 [Patent Document 3] US Patent Publication No. 2011 / 0299034 A1 Summary of the Invention [Problem to be solved by the invention]

[0010] However, to determine any number of functional ocular parameters, a corresponding number of trial sessions using specialized types of stimuli must be performed by the user and evaluated by the system, which may result in a lengthy procedure that strains the limits of patient compliance. The present invention seeks to remedy this drawback. For this reason, and to overcome the problems associated with methods known in the art, the present invention provides a computer-implemented method and a neuro-ophthalmoscope that aim to solve these problems. [Means for solving the problem]

[0011] Advantageous embodiments are set forth in the dependent claims. [Brief description of the drawings]

[0012] [Figure 1] FIG. 1 illustrates the measurement of pupil diameter according to the present invention to determine RAPD. [Diagram 2] FIG. 2 illustrates diagrammatically one embodiment of the present invention for measuring strabismus. [Diagram 3] FIG. 3 shows a schematic representation of another embodiment of the invention for measuring strabismus. [Figure 4] FIG. 4 shows a schematic diagram of the measurement of a human visual field. [Diagram 5] FIG. 5 shows stimuli and assessments for determining a person's visual acuity. [Figure 6] FIG. 6 shows a schematic diagram of a system according to the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] According to a first aspect of the present invention, there is provided a computer program for performing a method, in particular a computer-implemented method, for determining multiple afferent and efferent functional eye parameters, such as relative afferent pupillary defect (RAPD), one or more strabismus angles, visual field and / or visual acuity, when the computer program is executed on a computer, the computer program comprising a system comprising an optical system with a display system, in particular the display system comprising a first and a second display system, such as a first and a second screen. The display system is configured to present visual stimuli independently to the left and right eyes of a subject. The system further comprises an eye-tracking system configured to simultaneously, independently and in a time-resolved manner record the gaze direction and pupil size of the left and right eyes, in particular at a sampling rate, i.e. frame rate, better than 20 Hz, in particular at a sampling rate better than 50 Hz, more in particular at a sampling rate better than 200 Hz. The system further comprises said computer comprising a processor configured to control the optical system, for example to control the illumination luminance and duration of the visual stimuli on the display system, and to receive data from an eye tracking system, wherein an afferent pupillary defect (APD), in particular a relative afferent pupillary defect (RAPD), is determined from a first trial session consisting of a sequence of only a first type of stimuli presented in an automated manner to the left and right eyes of the subject using the display system, and / or the visual field of the left and right eyes of the subject is determined from a second trial session consisting of a sequence of only a second type of stimuli presented in an automated manner to the left and right eyes of the subject using the display system, and wherein strabismus is similarly determined from the first trial session and / or the second trial session. Strabismus may be characterized by one or more strabismus angles, such as horizontal strabismus angle, vertical strabismus angle, and / or torsional strabismus angle. Thus, the present invention is capable of determining strabismus by determining one, two, or all three of these strabismus angles.In particular, at least the horizontal strabismus angle is determined. In addition, it is also possible to determine the vertical strabismus angle. It should be noted that when determining the strabismus of a subject, any combination of the three strabismus angles may be determined.

[0014] The invention according to the first aspect may alternatively be claimed as a computer-implemented method.

[0015] The present invention solves the problem of providing a shortened and simplified method for measuring various functional eye parameters by a series of one type of visual stimuli, which allows the determination of multiple functional eye parameters using the same system. That is, multiple functional eye parameters are determined in an objective manner during one trial session. Furthermore, the present invention allows the measurement of functional eye parameters in an automated manner without the need for the subject to provide verbal or tactile feedback, thereby reducing the complexity of the test and eliminating sources of error. Furthermore, the fully automated execution allows the measurement time for evaluating various functional eye parameters to be reduced, since the subject and the medical personnel do not need to switch between different measurement systems.

[0016] It should be noted that in the context of this specification, the determination of an APD can also include the determination of a RAPD, such that a RAPD can be determined from the same data set when an APD is simultaneously or alternatively determined, and thus in the following only reference is made to APD, rather than both types.

[0017] The afferent and efferent ocular parameters, i.e. functional ocular parameters, may include one or more of the following groups: - APD and / or RAPD; - Strabismus angle; - saccadic peak velocity; - efferent pupillary function; - saccadic accuracy; - smooth pursuit; - Visual field, especially visual field determined by threshold perimetry; - visual acuity; - Fusional amplitude.

[0018] The optical system comprises a display system for displaying visual stimuli to the subject's eyes. To this end, the display system may comprise two display units or two displays configured to present visual stimuli to the left and / or right eye. This presentation may be performed independently for each eye, such that it is possible to present a visual stimulus only to a selected eye, while at the same time presenting no stimulus or a neutral stimulus to the other eye of the subject.

[0019] The display system may comprise two or more different computer screens used for desktop applications, or the display system may comprise only one computer screen optically separated along a perpendicular line into two display screen sections.

[0020] The system may include a chin rest for the subject to reduce head movement relative to the eye tracking system. Alternatively, the display system may include one or more near-eye displays or similar devices that are placed directly in front of the eyes, for example at a distance of less than 20 cm. The near-eye display, particularly in the form of a head-up display or virtual reality goggles (VR goggles), can be worn by the subject during the execution of the computer program and thus the method. This allows for a more accurate and controlled testing environment, particularly where a chin rest can be omitted with such a system. Furthermore, the use of a near-eye display allows the system to be used in clinical trials that require the subject to move their head while recording the gaze positions of both eyes. Furthermore, such a system can be designed as a portable system, allowing its use in field studies.

[0021] The system further comprises an eye-tracking system, which in particular has a time resolution of milliseconds, which corresponds to a frame rate in the range of several hundred Hz, allowing for a time-resolved recording of saccadic (saccadic) eye movements. Typically, eye-tracking systems have a frame rate or time resolution of 200 Hz or better.

[0022] The eye tracking system can be located on the display system or can be incorporated into a near-eye display, such as a VR goggle or similar device.

[0023] The eye tracking system is configured to record pupil size and gaze direction data for each eye independently. The recorded data can be evaluated by a computer or the eye tracking system.

[0024] The term "first" trial session as used in this specification is not to be understood as an indication that the first trial session must be the first trial session performed in a sequence of trial sessions, but is simply used to provide a distinction to different trial sessions, such as a second, third or fourth trial session (which may be performed before or after the first trial session).

[0025] A trial session may specifically include a sequence of at least one trial, where a trial includes at least one visual stimulus. In particular, a trial may include the presentation of visual stimuli to both eyes, either sequentially or simultaneously.

[0026] A visual stimulus is a stimulus that is presented to the subject's eyes. The stimulus may or may not be visible to the subject, for example, when the stimulus is a no-stimulus, a dark stimulus, or a neutral stimulus.

[0027] The visual stimuli of the first type of stimuli may or may not comprise a fixation object, or any object that allows the eye to focus on said object, in particular the first type of stimuli have a predetermined brightness such that upon presentation of the first type of stimuli the pupil size is constricted or dilated.

[0028] Thus, the first type of stimulus is designed to provide a stimulus of a predetermined brightness such that at least the eye to which the first type of stimulus is presented is exposed to a predefined and adjustable total brightness. By assessing pupillary constriction or dilation in response to the stimulus, several functional ocular parameters, such as RAPD, can be determined.

[0029] The first type of stimulus that is expected to cause the pupil of the eye to constrict is also referred to in the context of this specification as a light stimulus, and the first type of stimulus that is expected to cause the pupil of the eye to dilate is also referred to in the context of this specification as a dark stimulus.

[0030] In particular, the dark stimulus / no stimulus is represented by the black, specifically unilluminated, display state of the respective display system.

[0031] In particular, the first type of visual stimulus consists of stimulus images.

[0032] During a central or intermediate portion of the first trial session, a light stimulus can be presented to one eye and a dark stimulus can be presented to the subject's respective other eye at the same time. A dark stimulus can then be presented to one eye at the same time that a light stimulus is presented to the other eye, and this procedure is repeated several times. The first type of stimulus is switched between the subject's left and right eyes during the first trial session.

[0033] In particular, a light stimulus can be presented simultaneously to both eyes and thereafter a dark stimulus can be presented simultaneously to both eyes during an initial and / or final part of the first trial session, in particular at the beginning of the first trial session before the central or middle part is performed and / or at the end of the first trial session after the central or middle part is performed.

[0034] Performance of the initial and / or final portions in the first trial session may serve to establish and / or verify baseline values ​​for constricted and dilated pupil size for both eyes.

[0035] According to another embodiment of the invention, from the initial and / or final part of the first trial session, the efferent pupillary function or efferent pupillary defect is determined. In particular, the efferent pupillary function is determined from the speed at which the pupil dilates after switching from a light stimulus to a dark stimulus. If the dilation speed is below a predefined threshold, the subject may suffer from an efferent pupillary defect or an efferent pupillary dysfunction disorder, for example a disorder due to Horner's disease.

[0036] During the first trial session, pupil size, e.g., pupil diameter or pupil radius, is automatically determined by a computer or eye tracking system from data recorded by the eye tracking system for each trial in a time-resolved manner such that the time course of pupil size, for both eyes, can be determined in relation to the presented stimuli presented at any time in the time course.

[0037] By quantifying the change in pupil size during the first trial session, the ADP, and particularly the RAPD (and efferent pupillary function) can be determined for each eye. Details of how to determine the APD from the measurement data are detailed in the Examples section.

[0038] Both trial sessions included trials based on similar types of visual stimuli.

[0039] In particular, the first trial session consisted of only the first type of stimuli.

[0040] It should be noted that the display position can be expressed as a pair of angles that describe the position of the display relative to a central gaze direction or primary axis, as is well known to those skilled in the art.

[0041] According to another embodiment of the present invention, the execution of the first trial session comprises the following steps: - recording data with the eye tracking system, said data comprising information about pupil size and gaze direction of the first and second eyes of the subject during the first trial session, in particular a sampling rate of the pupil size and gaze direction having a sampling rate of more than 100 Hz, in particular more than 200 Hz, and in particular the data being recorded for at least 1 second; - determining the APD from the recorded data of the first trial session, in particular by computer analysis of the time course of pupil size of the left and right eyes in response to the presented first type of stimulus; - determining at least one strabismus angle or a plurality of strabismus angles from the recorded gaze directions of the first trial session by computer analysis of the magnitude and direction of saccadic eye movements that are specifically responsive to the presented first type of visual stimuli.

[0042] According to another embodiment of the present invention, the execution of the second trial session comprises the steps of: - recording by the eye tracking system data comprising information regarding the gaze direction of the first eye and the second eye of the subject during a second trial session, in particular wherein a sampling rate for gaze direction detection has a sampling rate of more than 200 Hz and in particular wherein said data is recorded for at least 1 second; - determining the visual field and at least one strabismus angle or a plurality of strabismus angles from the recorded gaze directions of the second trial session by computer analysis of the subject's saccadic eye movements in particular in response to the presented second type of stimuli.

[0043] In this embodiment, by performing a second trial session having a different type of visual stimulus compared to the first type of stimulus, strabismus can be determined simultaneously with determining the subject's visual field.

[0044] According to another embodiment of the invention, from the data recorded during the first and / or second trial session and from the sequence of the first or second type of stimuli, the following functional ocular parameters are determined: - saccade peak velocity, - Saccade accuracy, is determined from data of the first and / or second trial sessions.

[0045] In this embodiment, the invention is made even more versatile as multiple functional ocular parameters can be determined simultaneously using only a single measurement system by a computer program using only one or two trial sessions with one or two types of visual stimuli.

[0046] According to another embodiment of the invention, from the recorded gaze directions of the first trial session, one or more strabismus angles are determined using a computer by analyzing the magnitude and direction of saccadic eye movements or the deviation of the gaze direction of the non-fixating eye from the gaze direction of the fixating eye.

[0047] In particular, the deviation, eg the difference, of the gaze position / direction of the two eyes is determined by a computer and from this deviation the strabismus, in particular the strabismus angle or angles, is determined.

[0048] According to another embodiment of the invention, the deviation of the gaze position / direction of both eyes, in particular the difference between the gaze directions / positions, is determined by a computer and from this deviation strabismus, in particular one or more strabismus angles, is determined, wherein the deviation is determined at least once during a trial session, e.g. during a first, second (third, fourth or another trial session), wherein one eye is exposed to a visual stimulus configured to fixate the eye relative to the stimulus and the other eye is not exposed to such visual stimulus.

[0049] Further advantageous embodiments are disclosed below which, when the computer program is executed on a computer or system, enable the computer program to measure even more functional eye parameters on the same system using the same types of stimuli.

[0050] According to another embodiment of the invention, efferent pupil function of both eyes is determined from data of a sequence of a first type of visual stimuli recorded during a first trial session.

[0051] According to another embodiment of the invention, a smooth pursuit gain is determined from data recorded for a second type of sequence of visual stimuli during a second trial session.

[0052] According to another embodiment of the invention, only the first trial session is performed.

[0053] In this embodiment, a measurement session for determining two important functional eye parameters, the subject's APD and strabismus angle, can be performed quickly and reliably by running a single trial on the system.

[0054] According to another embodiment of the present invention, exactly two trial sessions, i.e. a first trial session and a second trial session, are performed and at least the APD, strabismus angle and visual field of the subject are determined from data of the sequences of the first type of visual stimuli and the second type of visual stimuli recorded during the first trial session and the second trial session, in particular the strabismus angle is determined from data recorded during either only the first or only the second trial session.

[0055] According to another embodiment of the present invention, each visual stimulus of the first type of visual stimulus comprises a fixation object displayed on the display system at a display position of the display system, the fixation object being a spatially limited graphical object enabling eye fixation (fixation) on the fixation object, in particular on a part of the fixation object.

[0056] The term compact especially refers to a spatially limited object, or a recognizable portion of a larger object, so small that the direction of gaze when viewing the fixation object indicates the location of the fixation object within 0.1°. In particular, the fixation object is smaller than 1°.

[0057] In particular, a fixation object is an object that can be darker or lighter than the background of the stimulus image.

[0058] For the determination of RAPD, the fixation object is not important, but for the determination of strabismus angle, a fixation object is required. Thus, when determining strabismus angle from the first trial session, the first type of stimuli comprises a fixation object.

[0059] For example, by evaluating the saccade amplitude and in particular the direction of the saccade movement when a first type of stimulus comprising a fixation object is switched from the left eye to the right eye and / or vice versa, the strabismus angle can be determined from the measurement data and diagnosed quantitatively, in particular by computer.

[0060] Computer-generated APD and strabismus measurements can be presented on an interface to trained medical personnel.

[0061] According to another embodiment of the invention, a first type of visual stimulus is displayed alternately to the right and left eye and repeated two or more times, in particular while a non-stimulus or dark stimulus is presented to the respective other eye, and the subject's pupil size and gaze direction are recorded for both eyes by an eye tracking system, in particular at a frame rate of at least 100 Hz.

[0062] This allows the APD and strabismus angle of each eye to be determined.

[0063] According to another embodiment of the present invention, the first trial session includes a plurality of gaze direction blocks, in which in each gaze direction block, a first type of visual stimulus is repeatedly and alternately presented to the right eye and the left eye, and a fixation object is displayed at different display positions in the different gaze direction blocks, and in particular, for each gaze direction block, the strabismus angle and the RAPD are determined separately.

[0064] The display location can be selected randomly from a set of display locations, however, it is possible to select the display location of the fixation object depending on the detected corrective saccadic eye movement of the eye when the first type of visual stimulus is switched from one eye to the other.

[0065] In particular, the display positions of the different gaze direction blocks are arranged on the visual field of the subject, the display positions being arranged in particular in sectors of a 3x3 matrix, in particular one of the display positions, in particular the central display position, corresponds to the main gaze direction, i.e. straight ahead gaze, and in each gaze direction block, only one such sector is addressed by the display position. In this way, the strabismus angle can be measured between each gaze direction block for the different sectors. The sectors may be referred to as combinations of common gaze directions in the vertical and horizontal directions, for example, right down, only up, only left, left up, etc. The main gaze direction can be defined as a gaze direction that is essentially straight ahead relative to the head.

[0066] During each gaze direction block, data regarding pupil size is recorded to determine the APD.

[0067] As detailed above, during each gaze direction block, a first type of visual stimulus is repeatedly presented to the eye, and this embodiment allows for averaging of detected saccadic movements and pupil size to obtain more accurate results regarding strabismus angle and ADP from the first trial session.

[0068] In order to determine strabismus in more detail, the following embodiment teaches the advantageous performance of a first trial session.

[0069] According to another embodiment of the invention, the fixation object is displayed at the same display position in the same gaze direction block, and each time the first type of stimulus switches from the left eye to the right eye or from the right eye to the left eye, the amplitude and direction of the saccadic eye movement are determined from the recorded saccadic eye movements, and in particular the strabismus angle is determined for each gaze direction block, such that the strabismus angle is determined in relation to the gaze direction.

[0070] The detected saccadic eye movements can be evaluated in particular by determining a saccade starting point, which is recorded for both eyes when a first type of visual stimulus is switched from one eye to the other eye, and a saccade end point, which is determined for both eyes after the time taken for the eye to which the fixation object is presented after the switch of stimuli to focus on the fixation object.

[0071] The direction defined by the vector pointing from the start point to the end point provides information about the direction of the strabismus, and the length of said vector corresponds to the amplitude of the saccadic eye movement and can be related to the magnitude of the strabismus.

[0072] Furthermore, it is also possible to determine torsional strabismus, which is related to the torsion of the eye, which is recorded by an eye-tracking system and can be evaluated by a computer from the data of the eye-tracking system, in particular also from the torsion state at the start of the saccadic eye movement and the torsion state at the end of the saccadic eye movement, which is derived from the torsion state at the start and end of the saccadic movement.

[0073] The saccadic eye movement in response to the switching of the first type of stimulus is characterized, inter alia, by a direction pointing from the saccade start point to the saccade end point, an amplitude indicating the distance between the saccade start point and the saccade end point, and a twist between the saccade start point and the saccade end point, and a strabismus angle is determined, inter alia, from at least one saccadic eye movement, or from multiple saccadic eye movements.

[0074] The strabismus angle can be expressed as a horizontal angle, a vertical angle, and a torsion angle for each gaze direction.

[0075] It should be noted that the term "same" display position with respect to the first and second display systems refers to corresponding display positions on the first and second display systems that are considered to correspond to the same gaze direction in an ideal eye model (no strabismus).

[0076] According to another embodiment of the present invention, the magnitude and direction of the saccadic eye movement are determined from the recorded saccadic eye movement each time the first type of stimulus switches from the left eye to the right eye or from the right eye to the left eye, and in a subsequent presentation of the first type of visual stimulus to the same eye in the same gaze direction block, the display position of the fixation object is adjusted so as to correct the saccadic eye movement in amplitude and direction as determined from the first type of stimulus presented earlier in the gaze direction block, in particular until the saccadic movement is minimized within the same gaze direction block, and in particular the strabismus angle corresponds to this adjusted display position, and in particular the strabismus angle is determined for each gaze direction, such that the strabismus angle is determined for one gaze direction.

[0077] This embodiment allows for a more robust determination of strabismus angle as it is less dependent on accurate values ​​from eye tracking and only requires that non-movement of the eyes be demonstrated.

[0078] The terms and definitions of the previous embodiment also apply to this alternative embodiment.

[0079] This embodiment essentially aims to correct corrective saccadic eye movements by presenting a fixation object to the eyes in a shifted and / or rotated manner. In this way, the magnitude, direction and especially the torsion of the strabismus can be determined directly from the position and degree of rotation of the fixation object.

[0080] The strabismus angle is determined, inter alia, by measuring the amplitude and direction between vectors pointing from the start to the end of a saccadic eye movement in response to a switch in the first type of stimulus, and assigning to the strabismus angle its magnitude and opposite direction relative to the adjusted viewing position.

[0081] According to this embodiment, the disparity of the visual stimuli presented to both eyes is used to calculate the strabismus angle. In particular, the disparity is defined as the direction and amplitude of the adjustment applied to the fixation object to correct the corrective saccadic eye movement. The strabismus angle can be expressed as horizontal, vertical and torsion angles for each gaze direction.

[0082] According to another embodiment of the present invention, each visual stimulus of the second type of visual stimuli includes a luminance object displayed on a uniform background at a relative position on a display system, and during a second trial session, the luminance objects of the second type of visual stimuli are displayed sequentially at a plurality of selected relative positions, the second type of visual stimuli are displayed alternately or sequentially to the right eye and the left eye, in particular, each other eye is presented with a neutral stimulus identical to the second type of stimuli without the luminance object, and each time a luminance object is displayed at a selected relative position, it is determined by the computer whether the subject has detected the luminance object at the selected relative position, and if the subject detects the luminance object, the luminance object is displayed at the selected relative position. Then, in particular at a reduced luminance, the luminance object is displayed at a different selected relative position, where the luminance object is displayed again at the selected relative position in a subsequent trial at a reduced luminance (compared to the luminance at which the subject detected the luminance object at this selected relative position), where if the subject does not detect the luminance object at the selected relative position, the luminance object is repeatedly displayed at the selected relative position, with increasing luminance, until the subject detects the luminance object, not necessarily thereafter, thereby determining the luminance detection threshold of each eye of the subject for each selected relative position, whereby the visual field is determined in the form of a threshold perimetry.

[0083] The relative positions depend on the subject's current gaze direction. Therefore, the relative positions are provided in a gaze-centered coordinate system. The current gaze direction can be determined by an eye-tracking system.

[0084] The relative positions may be selected from a plurality of relative positions distributed in a quadrant of the field of view, in particular 20, 50 or more relative positions.

[0085] A luminance object is a spatially confined object that is so small that the direction of gaze when viewing the luminance object indicates the location of the luminance object within 0.1°. In particular, a luminance object is larger than 0.1°. For example, a luminance object may have a diameter in the range of 0.1-1.7°, in particular a diameter in the range of 0.3-0.7°, and is placed against a background of uniform luminance.

[0086] The luminance object may be adjusted in terms of its relative position and its luminance and / or size in the second type of stimulus presented to the eye.

[0087] In particular, when the brightness is adjusted, the brightness is decreased or increased by 2 dB to 10 dB, more particularly 2, 4, 6, 8, or 10 dB. The brightness of the object can be controlled by a computer.

[0088] The measurement method with a luminance object located relative to the current gaze direction allows different types of evaluations and tests to be performed without the subject having to constantly gaze in a specific direction. Therefore, this test situation requires less adherence from the subject to the test setup and the execution of the method. As described below, the determination of the visual field can be performed in a fully automated manner. Feedback of whether the subject has detected the luminance object can be provided by the subject simply looking at the luminance object, compared to performing additional actions such as pressing a button or speaking out loud. This makes the method more intuitive and less prone to errors.

[0089] The term luminance object specifically relates to the function of the object, namely, its luminance being able to be changed during the second trial session.

[0090] Thus, the first type of visual stimuli and the second type of visual stimuli differ at least in that the luminance of the first type of visual stimuli is not adjusted during the trial session.

[0091] Luminance objects can be presented as bright objects on a uniform grey or black background with continuous background luminance.

[0092] The second trial session allows for threshold perimetry of the visual field, for which the relative position can be randomly selected from multiple relative positions.

[0093] According to another embodiment of the present invention, the luminance object is deemed to be detected by the subject if a saccadic eye movement toward the displayed luminance object is recorded by the eye tracking system within a first time interval during which the luminance object is displayed, and in particular, the luminance object stimulus is deemed not to be detected by the subject if the first time interval is about 500 milliseconds and no saccadic eye movement toward the luminance object is recorded by the eye tracking system within the first time interval. The duration of the first time interval can be selected to be at least as long as two standard deviations of the mean response time to the visible stimulus, in particular twice as long as the mean response time.

[0094] In particular, the second type of visual stimulus, i.e. the luminance object, is deemed to be detected by the subject only if the first saccade of the eye to which the luminance object is presented is greater than 2°, more particularly greater than 3°, towards the relative position of the position of the luminance object.

[0095] More specifically, for each second type of stimulus a virtual hit box is defined extending around the location of the luminance object, the size of the hit box being dependent on the location of the luminance object, with the size of the hit box being closer together at locations closer to the central region of the visual field and larger in peripheral regions of the visual field.

[0096] The determination of whether a visual stimulus has been detected, i.e. whether a luminance object has been detected by the subject, is performed automatically and reliably so that accidental saccades can be ruled out by determining whether there is a correlated saccade upon presentation of the luminance object and whether this saccade is in the correct direction, i.e. towards the luminance object, and also whether it is sufficiently along the correct direction towards the luminance object.

[0097] When the eye detects the luminance object (i.e., when its relative position exceeds the eye's perception threshold), a saccadic movement of the eye toward the luminance object allows an automatic determination of whether the subject detected the luminance object when displayed.

[0098] In this embodiment, automated measurement of the visual field can be performed without the subject having to provide non-visual feedback, such as audio instructions or button presses.

[0099] According to another embodiment of the present invention, the strabismus angle is determined for a relative position selected from saccadic movements, in particular from the amplitude and direction of saccadic eye movements, when the second type of stimulus switches from the left eye to the right eye or from the right eye to the left eye and when the luminance object is deemed to be detected by both eyes.

[0100] According to another embodiment of the present invention, a gaze direction resetting routine is performed, said routine comprising the steps of: - determining, in particular, whether the selected relative display position is located outside the physical tracking limits of the eye tracking system or the physical display limits of the display system, and if "yes": - presenting a suprathreshold object, such as a fixation object or luminance object, having a suprathreshold luminance that exceeds the luminance detection threshold in the current gaze direction of the eye; - moving the above-threshold objects along a trajectory at predetermined horizontal and vertical velocities to new display positions; - hiding objects, especially above a threshold; - performing the steps of the method of the previous embodiment at a selected relative position determined to be outside the physical display limits or physical tracking limits of the eye tracking, in particular before performing said gaze reset routine.

[0101] This gaze direction reset routine may be performed, for example, if the selected relative position at which the trial is performed is outside the display limits of the display system, for example the physical horizontal screen limits.

[0102] Additionally, the gain of smooth pursuit can be determined by evaluating eye movements to objects above a moving threshold from the gaze reset routine.

[0103] Thus, the gaze reset routine may be performed during the first and / or second trial session, or during any other trial session.

[0104] Gaze reset routines may also be necessary and useful, for example, when the visual field needs to be assessed at a relative position and most or all of the other relative positions for probing the visual field have already been tested, after which the subject's gaze direction is reset so that the relative position at which a trial is performed is within the physical limits of the display system or the physical tracking limits of the eye-tracking system.

[0105] According to another embodiment of the present invention, during the gaze reset routine, the above-threshold object has a predetermined velocity pattern, particularly in a sequential manner, along the horizontal and vertical directions (as viewed by the subject), and wherein the deviation between the velocity of the detected eye movements following the above-threshold object and the velocity pattern of the above-threshold object is determined for each direction of movement of the above-threshold object, so that smooth tracking can be determined from the gaze reset routine.

[0106] According to this embodiment, for example, in the second trial session, the second type of visual stimulus is selected as a luminance object having a luminance above the subject's detection / perception threshold, where the luminance object is displayed to the subject so as to be presented in the current gaze direction, i.e., "directly in front" of the gaze direction, and the luminance object moves with a predetermined speed pattern. In this case, the above-threshold object corresponds to the luminance object.

[0107] Similarly, the routine may be performed and evaluated during a first trial session with the fixation object, or may be performed and evaluated during a further trial session with a different object.

[0108] Note that an object above the threshold may be a dark object on a light background or vice versa.

[0109] This embodiment makes it possible to incorporate the determination of smooth pursuit in the first or second trial session, for example by using the same first or second type of visual stimuli.

[0110] According to another embodiment of the invention, the functional ocular parameters determined are: - subject's fusion width; Further comprising: Here, in order to determine the fusion width, the method comprises the steps of: - performing a third trial session, the third trial session including a third type of visual stimuli presented simultaneously to the left and right eyes of the subject using the optical system; - recording data during the third trial session including gaze direction information; - determining at least a fusion width by computer-analysing the vergence between the subject's left and right eyes in response to the presented third type of visual stimuli of the third trial session from the recorded gaze directions of the third trial session; Further includes:

[0111] According to another embodiment of the present invention, a third type of visual stimuli comprises images having a local spatial structure (each structure having multiple distinct spatial frequencies), and at the start of the third trial session, the images for the left and right eyes are positioned at zero image disparity requiring zero vergence, and thereafter images are presented to the left and right eyes with, in particular, successively increasing or decreasing disparity, in particular the disparity may be horizontal, vertical or torsion disparity.

[0112] This embodiment allows for the determination of the fusional width by determining the maximum horizontal and / or vertical vergence angle of the eyes at which the subject can still correct the image disparity / disparity of the displayed third type stimulus by vergence eye movements. Any increase in image disparity at this point destroys fusion and vergence decays to a steady state (ideally 0 degrees).

[0113] According to another embodiment of the invention, the functional ocular parameters determined are: - The subject's visual acuity; Further comprising: To determine visual acuity, the computer program includes the steps of: - performing a fourth trial session, wherein said fourth trial session comprises a plurality of simultaneous fourth type visual stimuli presented by the optical system (4) to the left eye and / or to the right eye of the subject; - recording data during the fourth trial session including information regarding gaze direction; - determining at least visual acuity from the recorded data of the fourth trial session by computer analysis of the movements, and in particular the correlation of the movements, of the left and right eyes of the subject in response to the presented fourth type of visual stimuli in the fourth trial session; Then, execute the following command again.

[0114] A fourth type of visual stimulus for determining visual acuity may comprise a plurality of patches arranged on a background, said patches being isoluminant with respect to the background, and said patches may be characterized in that they exhibit a luminance distribution that varies periodically with spatial frequency, in particular with only one spatial frequency, where each patch is a bounded set covering only a portion of the background.

[0115] According to another embodiment of the present invention, the fourth type of visual stimulus comprises a plurality of patches, in particular Gabor patches, arranged within an area of ​​the display system, in particular said patches, in particular Gabor patches, are irregularly arranged across the area of ​​the display system, in particular said patches, in particular Gabor patches, are identical to one another, i.e. the patches have the same size and shape.

[0116] According to another embodiment of the invention, at least some, in particular all, of the patches are Gabor patches.

[0117] According to another embodiment of the invention, during the fourth trial session, the patch moves back and forth at the same speed and along a predetermined trajectory, where an eye tracking system records eye movements of the eyes (possibly both eyes) in response to the moving patch, in particular the Gabor patch.

[0118] During the fourth trial session, a patch can be presented to only one eye, and then to the other eye, so that monocular visual acuity can be measured.

[0119] Wherein, during the fourth trial session, the size of the patch is continuously reduced or increased, in particular after the patch has been moved at least once along the predetermined trajectory, and the trials of the fourth trial session include moving the patch of one size selected during the fourth trial session.

[0120] According to another embodiment of the invention, the visual acuity of the subject is determined from the correlation between the recorded eye movements and the movement of the patch, in particular from the patch size or spatial frequency at which the eye movements deviate from the movement of the patch by a predefined value, this deviation being measurable in the form of a least square deviation of the eye movements from the movement of the patch.

[0121] According to another embodiment of the invention, the fourth visual stimulus consists of a uniform area of ​​color and luminance on which the patches are irregularly or randomly arranged, i.e. the patches move on a uniform background.

[0122] In particular, the patches maintain a constant distance from each other, that is, as the patches move, the pattern in which the patches are disposed relative to each other does not change.

[0123] According to another embodiment of the invention, the Gabor patches are defined by a Gaussian kernel function with variance, in particular isotropic variance, said Gaussian kernel function being modulated by a sinusoidal plane wave with a given direction and a given period.

[0124] According to another embodiment of the present invention, the period of the sinusoidal plane wave is in the range of variance and triple variance.

[0125] In particular, a sinusoidal plane wave is centered with the maximum amplitude at the location of the mean value of a Gaussian kernel function.

[0126] According to another embodiment of the invention, the ratio of the variance of the Gaussian kernel of a Gabor patch to the period of the sinusoidal plane wave is constant and in particular does not depend on the size of the Gabor patch.

[0127] According to another embodiment of the invention, the patch moves along a direction, in particular a horizontal or vertical direction, wherein the speed of the patch varies periodically, in particular sinusoidally, such that the patch moves back and forth along said direction periodically, in particular sinusoidally.

[0128] According to another embodiment of the invention, the periodic rate has a frequency between 0.02 Hz and 2 Hz, more particularly between 0.05 Hz and 0.5 Hz.

[0129] According to another embodiment of the invention, the patch has a contrast of 10-20 on a uniform background.

[0130] According to another embodiment of the present invention, the gaze directions of the left and right eyes are recorded by an eye tracking system during any of the trial sessions, and wherein the strabismus angle is determined by subtracting the recorded gaze directions of the left and right eyes, in particular, the gaze directions of the eyes are recorded during the presentation of the first, second, third or fourth type of stimuli.

[0131] It should be noted that any of the trial sessions may be run independently of each other on the system.

[0132] Thus, with particular reference to the embodiment relating to the fourth trial session, a set of independent items describing the invention independently of any previous embodiment can be stated as follows:

[0133] Item 1) A method, particularly a computer-implemented method, for determining visual acuity using a system comprising an optical system comprising a display system configured to project visual stimuli independently to the left and right eyes of a subject, an eye-tracking system configured to record the gaze directions of the left and right eyes, and a computer configured to control the optical system and receive recorded data from the eye-tracking system, the method comprising at least the following steps: - performing a trial session, said trial session comprising a plurality of visual stimuli presented by means of an optical system to the left and / or right eye of the subject, in particular comprising a plurality of visual stimuli presented simultaneously; - recording data during said trial session, including information regarding said gaze direction; - determining at least visual acuity from the recorded data of said fourth trial session by computer analysis of the movements of the subject's left and right eyes in response to the presented fourth type of visual stimuli of said fourth trial session, in particular the correlation of said movements; The method comprising:

[0134] The definitions and terms used herein also apply to this independent embodiment.

[0135] Item 2) The method of item 1, wherein the fourth type of visual stimulus comprises a plurality of Gabor patches arranged across an area of ​​the display system, in particular the Gabor patches are irregularly arranged across the area of ​​the display system, in particular the Gabor patches are identical to each other, i.e. the Gabor patches have the same size and shape.

[0136] Item 3) During the fourth trial session, the Gabor patch moves back and forth at the same speed and along a predetermined trajectory, and the eye tracking system records eye movements in response to the moving Gabor patch. The method of any one of items 1 and 2.

[0137] Item 4) The method of any one of items 1 to 3, wherein during the fourth trial session, the Gabor patch may be presented to only one eye and then subsequently to the other eye so that monocular visual acuity may be determined.

[0138] Item 5) The method according to any one of Items 1 to 4, wherein during the fourth trial session, the size of the Gabor patch is continuously decreased or increased, particularly after the Gabor patch has moved at least once along a predetermined trajectory. The trial of the fourth trial session includes the movement of a Gabor patch of one size selected during the fourth trial session.

[0139] Item 6) The method according to any one of items 1 to 5, wherein the visual acuity of the subject is determined from the correlation between the recorded eye movements and the Gabor patch movements. The visual acuity is determined in particular from the size of the Gabor patch at which the eye movements deviate from the Gabor patch movements by a predefined value. This deviation can be measured in the form of a least square deviation of the eye movements from the Gabor patch movements.

[0140] Item 7) The method according to any one of items 1 to 6, wherein the fourth visual stimulus comprises, in particular consists of, an area of ​​uniform color and luminance in which Gabor patches are randomly arranged, i.e., the Gabor patches move on a uniform background.

[0141] In particular, the Gabor patches maintain a constant distance from each other, meaning that their arrangement pattern does not change even if the Gabor patches move.

[0142] Item 8) The method according to any one of items 1 to 7, wherein the Gabor patch is defined by a Gaussian kernel function having a variance, in particular an isotropic variance, and the Gaussian kernel function is modulated by a sinusoidal plane wave having a predetermined direction and a predetermined period.

[0143] Item 9) The method according to any one of Items 1 to 8, wherein the period of the sinusoidal plane wave is within the range of dispersion and triple dispersion.

[0144] In particular, a sinusoidal plane wave is centered with the maximum amplitude at the location of the mean value of a Gaussian kernel function.

[0145] Item 9) The method according to any one of items 1 to 8, wherein the ratio of the period of the sinusoidal plane wave of the Gabor patch to the variance of the Gaussian kernel is constant, in particular, is constant regardless of the size of the Gabor patch.

[0146] Item 10) The method according to any one of items 1 to 9, wherein the Gabor patch moves along a direction, particularly a horizontal or vertical direction, and wherein the speed of the Gabor patch varies sinusoidally so that the Gabor patch moves back and forth sinusoidally along the direction.

[0147] Item 11) The method according to any one of Items 1 to 10, wherein the sine wave has a frequency of 0.02 Hz to 2 Hz, more particularly 0.05 Hz to 0.5 Hz.

[0148] Item 12) The method according to any one of Items 1 to 11, wherein the Gabor patch has a contrast of 10 to 20 on the uniform background.

[0149] According to a third aspect of the invention, a neuro-ophthalmoscope comprises the features of the system as well as program code stored on a computer for carrying out the method according to the invention.

[0150] Further, the optical system and the eye tracking system are provided in a near-eye display such as VR goggles, or the optical system comprises a desktop screen and a separate eye tracking system disposed on the computer screen, and when the neuro-ophthalmoscope comprises VR goggles, the goggles further comprise an adjustable lens assembly for each eye such that optical aberrations of each eye of the subject can be corrected by the lens assembly.

[0151] The term "computer program" specifically refers to program code stored in a computer for carrying out the method. The program is computer readable code.

[0152] In particular, the computer program is stored on a non-transitory storage medium that can be provided by the computer.

[0153] Further, according to an aspect of the present invention, a computer program product stored on a non-transitory storage medium is disclosed that includes computer program code of a computer program that, when executed, causes a computer and / or system to perform the methods described herein.

[0154] In particular, exemplary embodiments are described below in conjunction with figures, which are accompanied by claims and texts explaining individual features of the illustrated embodiments and aspects of the invention. Individual features shown in the figures and / or described in said text of the figures may be incorporated (even in separate manner) in the claims relating to the device according to the invention. EXAMPLES

[0155] In the following, an exemplary system according to the invention is disclosed, however, it should be noted that it is also possible to use other systems capable of carrying out the method according to the invention in the same manner.

[0156] The system includes a display system including two displays positioned in front of the subject's eyes, the display system including two displays configured to independently display visual stimuli to the eyes, a first one of the displays positioned to present the visual stimuli to the right eye and a second one of the displays positioned to present the visual stimuli to the left eye.

[0157] Furthermore, the displays are positioned such that visual stimuli can only be presented to one eye, and each eye can only perceive one display. The crosstalk between these displays is 0.2 cd / m 2 must be less than.

[0158] These displays may have an associated coordinate system that describes the display position or location where a visual stimulus or object may be displayed. The coordinate system is essentially the same for both displays, and identical coordinates correspond to the same gaze direction with respect to an eye model with normal functional eye parameters, i.e., a strabismus angle of 0 degrees.

[0159] Additionally, the system includes an eye tracking system configured to record the eye gaze direction and pupil size, and may be equipped such that eye rotation and other related parameters can also be determined.

[0160] This eye-tracking system has a frame rate of over 200 Hz and is capable of resolving eye saccades into a series of images.

[0161] The eye tracking system may be integrated into the display system or placed in close proximity to the display system, ensuring that the subject's eyes are always visible to the eye tracking system during the trial session.

[0162] The eye tracking system can record data in the form of images of the subject's eyes. The eye tracking system can include modules for determining several eye parameters, such as eye position, pupil position, pupil size, and / or gaze direction.

[0163] The module can transfer the ocular parameters to a computer or include this data in the image data recorded by the eye tracking system.

[0164] The accuracy of determining the pupil size must be better than 0.01 mm, while the accuracy can be better than 0.05 mm.

[0165] Furthermore, in order to determine gaze direction accurately enough, the eye tracking system needs to be configured with an accuracy that is better than 1°.

[0166] The eye-tracking system is connected to the system's computer so that data can be exchanged between the computer and the eye-tracking system.

[0167] The computer is configured to control the eye-tracking system and the display system and thus to carry out, by means of a computer program stored thereon, the steps of the method according to the invention, in particular the computer-implemented method of the invention. The method can be executed on the computer in the form of a computer program, which causes the computer to control the display system and the eye-tracking system of the system, such that the recording and the display of the visual stimuli are coordinated by the computer.

[0168] Further, the computer is configured to analyze the recorded data from the eye-tracking system, and in particular, the computer is capable of time-correlating the recorded data of the eye-tracking system with the presented visual stimuli.

[0169] The display system may include a lens assembly configured to be adjusted for the subject's near vision.

[0170] The display system and eye tracking system may be provided in a single device, i.e., a near-eye display, worn as a headset by a person, for example in the form of virtual reality goggles (VR goggles), which may include a lens assembly.

[0171] The system according to the present invention can then be used to carry out the method to determine a number of functional ocular parameters.

[0172] General design of visual stimuli When performing an eye test, a variety of different factors affect the state and response of the eye, such as accommodation, convergence, expected brightness, expected size of the object, state of arousal, and mental load.

[0173] One of the main problems when conducting tests that require participants to look into a binocular viewing device is the lack of control over accommodation and accommodative vergence. This problem is particularly evident when using only monocular stimuli during or part of a trial session. In these situations, the mechanism of binocular fusion is no longer present, so that vergence eye movements are mostly determined by accommodative vergence.

[0174] To address this issue, the system is configured to present binocular disparity correct three-dimensional appearing scenes containing visual stimuli during a trial session. The stimuli are configured in a manner that presents objects of known size, thereby providing visual cues to guide accommodation and vergence.

[0175] For example, in trials designed to induce changes in pupil size, the following visual stimulus designs were tested:

[0176] Maximum brightness (light stimulus) and / or darkness (dark stimulus) are repeated multiple times to one or both eyes, alternating or synchronously.

[0177] A fixation object that can be in the center of the first type of visual stimulus allows the subject to have a stable gaze position during the first trial session. The design of the fixation object during the light / dark alternating stimuli of the first trial session is important. A monochromatic fixation object such as a red dot was tested. However, such a stimulus significantly altered the subject's color perception depending on the surroundings, resulting in subsequent double vision. A crosshair cursor and a bullseye target were also tested, but none of the fixation objects provided reliable fusion. The fixation object that showed the best results without distorting the subject's other visual perceptions was a fixation object with multiple color patches, for example a balloon showing multiple color patches.

[0178] Colored balloon-shaped fixation objects can be used to determine RAPD.

[0179] Determination of APD and RAPD from pupil size and the first trial session Below are provided one or more examples for several functional ocular parameters, detailing how each parameter is determined.

[0180] Traditionally, afferent pupillary defect (APD) is determined by the so-called swinging flashlight test, but this test tends to depend on the expertise of the person performing and evaluating the test, as well as the compliance of the subject.

[0181] The present invention allows tests to be performed repeatedly and reliably in an automated and objective manner.

[0182] Automatic performance of the APD determination requires a system as described in the context of this specification.

[0183] To determine the APD, a first trial session is performed by the subject. The first trial session consists of a number of trials. A trial consists of at least one first type of visual stimulus presented sequentially to at least one eye of the subject. During the trial session, the eye tracking system continuously records the pupil size and gaze direction of both eyes.

[0184] The visual stimuli used in this example for the first trial session are a first type of stimulus that comprises a fixation object, even though a fixation object is not required for the specific purpose of the test regarding the determination of APD.

[0185] The first type of stimuli are those that are bright, or luminous, enough to be expected to cause pupil constriction in healthy individuals, i.e., those not specifically affected by APD. This luminance is around 30 cd / m 2 However, the maximum is 50 cd / m 2 It could be.

[0186] Optionally, at the beginning or end of the first trial session, a dark or non-stimulus may be presented simultaneously to both eyes, capable of dilating the subject's pupils for at least a few seconds or minutes (T0-1, T0-2) (Figure 2, Figure 3). From this measurement, a baseline pupil size can be calculated independently from the recorded time course of the pupil size of each eye. Then, a first type of stimulus is presented simultaneously to both eyes of the subject for a few seconds, such that the minimum pupil size of the binocular pupil constriction is determined independently from the recorded time course of the binocular pupil size.

[0187] After this arbitrary initial alignment, the minimum and maximum pupil size is known for each eye.

[0188] The subject is then presented with a sequence of trials during which a first type of stimulus, i.e. light stimuli, are presented to alternating eyes and a dark stimulus to each other eye. That is, starting with the left eye, a light stimulus is presented to the left eye for, say, 3 seconds, and a dark stimulus is presented to the right eye for the same duration. Next, a light stimulus is presented to the right eye and a dark stimulus is presented to the left eye for the same duration. The presentation location of the fixation object is only a secondary property for determining the APD.

[0189] This sequence is repeated at least once. To evaluate the recorded data, a frame rate of the eye-tracking system of 60 Hz may be sufficient.

[0190] The first trial session yields a recorded time course of pupil size having hundreds to thousands of data points.

[0191] From the time course, the processor determines the maximum pupil size before switching the light stimulus and the minimum pupil size immediately after switching, and in particular the time course of each eye is smoothed against outliers with a smoothing algorithm. Thus, from the time course of both eyes, the processor can calculate the relevant amplitude of the change when exposed to the first type of stimulus. Thus, for each eye, the amplitude between the constricted and dilated pupil is calculated. The difference in the pupil response, i.e. the amplitude between the left and right eyes, indicates the magnitude of the relative afferent pupil defect (RAPD). The absolute amplitude compared to normal data of healthy subjects indicates the afferent pupil defect (APD). This is determined for each eye.

[0192] Optionally, average the pupil size of the left and right eye. For this averaged trace, determine the average pupil size from 0 ms to 80 ms after the onset of the light stimulus. From this value, subtract the smallest pupil size reached after the onset of the light stimulus across all trials. This calculation gives the pupil amplitude. Compare the pupil amplitude of the left and right eyes. The difference indicates the size of the RAPD.

[0193] The second approach consists of subtracting the mean pupil size at the beginning and end of each trial. This value is determined by subtracting the value for the light stimulus for the right eye from the value for the light stimulus for the left eye. The sign and magnitude of the value obtained indicate which eye is affected by the RAPD and to what extent.

[0194] The time course through the first trial session and the associated recorded temporal pupil size are shown in Figure 1. In this example, a RAPD in the right eye is detected because the amplitude of the change in light stimulus from the right eye to the left eye is greater than the amplitude of the change in pupil size from the left eye to the right eye.

[0195] One advantage of the present method is that strabismus angle can also be determined within one trial session using the same type of visual stimuli.

[0196] Determination of efferent pupillary function The initial and final portions of the first trial session may be conducted as detailed above to establish baselines of constricted and dilated pupil size at the beginning or end of the first trial session. To this end, a light stimulus may be presented simultaneously to both eyes followed by a dark stimulus presented simultaneously to both eyes, or vice versa.

[0197] From the initial and / or final portion of the first trial session, the efferent pupillary function or efferent pupillary defect is determined. In particular, the efferent pupillary function is determined by the processor from the recorded time course of the size of the eye's pupil. The efferent pupillary function is determined from the speed or time interval that the pupil dilates after switching from a light stimulus to a dark stimulus. If the dilation speed is below a predetermined threshold speed or if the time interval is longer than a predetermined time interval, the subject may suffer from an efferent pupillary defect or an efferent pupillary dysfunction disorder (e.g., a disorder due to Horner's disease).

[0198] The rate of dilation can be determined from the slope of the time course or by determining the time interval required for the pupil to dilate after the stimulus switches from light to dark.

[0199] Determination of strabismus angle from the first trial session 2 and 3, to determine the strabismus angle from the first trial session in addition to the RAPD, the first type of stimulus comprises a fixation object. The fixation object can be a spatially limited object that allows the subject to fixate the gaze on the fixation object. For example, the object can be a bright dot with a diameter on the order of 1° or an object displayed in a landscape.

[0200] In the first trial session, in different trials T1, T2, T3, and T4, the first type of stimulus is repeatedly presented alternately to the left and right eyes as described in the previous section.

[0201] Eye and pupil recordings from the eye tracking system are filtered to remove blink events from the data set. Data with eye movement velocities faster than 600° / s are removed from the data set.

[0202] In a first embodiment of the determination of the strabismus angle, the following steps are performed:

[0203] The first trial session is subdivided into gaze direction blocks, where during each gaze direction block, during trials T1, T2, T3, T4, the fixation object is displayed at the same display location, and during different gaze direction blocks, the fixation object is displayed at different selected display locations. In general, nine display locations are selected from a 3 × 3 matrix centered on the primary gaze direction (i.e., directly in front of the center, 0,0). Each selected display location is a combination of one of three horizontal gaze directions selected from the tuple [-α,0°,+α] with α in the range of 10° to 25° and one of three vertical gaze directions selected from the tuple [-β,0°,+β] with β in the range of 10° to 25°.

[0204] Thus, during the first trial session, nine gaze direction blocks were performed, during which the first type of stimuli alternated between the right and left eyes as described for the determination of the APD, while for each gaze direction block a fixation object was presented at one of the selected display locations.

[0205] The recorded gaze direction 100 and pupil size data are evaluated for APD as described above and for strabismus angle. For the strabismus angle, a corrective saccade 101 of the eye is recorded each time the first type of stimulus 11 switches from the left eye to the right eye and vice versa. If the subject does not suffer from strabismus, there may be no corrective saccade. If the subject suffers from strabismus, a corrective saccade will be prominent. The direction and amplitude of the corrective saccade can quantify the strabismus angle. Furthermore, the strabismus angle can be determined in relation to its vertical, horizontal or torsional magnitude by the choice of the display position of the fixation object. Thus, the horizontal, vertical and / or torsional strabismus angle can be determined for the first trial session.

[0206] In particular, the left eye's horizontal gaze position / direction is subtracted from the right eye's horizontal gaze position / direction when the gaze is directed at one of the nine viewing positions, resulting in one value for the horizontal relative deviation, i.e. horizontal strabismus angle, with respect to the viewing position, i.e. gaze direction, for each of the nine viewing positions.

[0207] In a similar manner, the vertical and twist strabismus angles can be calculated for each of the nine viewing positions.

[0208] Thus, the direction, amplitude, and torsion of this modified saccadic eye movement indicate the horizontal, vertical, and torsional strabismus angles of each eye.

[0209] In this embodiment, a single trial with one type of visual stimulus can be used to determine APD and strabismus angle, effectively integrating two different tests into one test series, thereby reducing the time required to establish two functional eye parameters.

[0210] In another embodiment, the strabismus angle is determined by the following steps:

[0211] The first trial session according to this alternative embodiment is subdivided into gaze direction blocks, with the fixation object being displayed at different selected display locations in different gaze direction blocks.

[0212] In the first gaze direction block, as described in the previous section, a first type of object is repeatedly displayed alternately to the left and right eyes. The stimulus has a fixation object at the display position.

[0213] However, the corrective saccade is evaluated after the first visual stimulus is switched from one eye (e.g., the left eye) to the other eye (e.g., the right eye). Now, according to the evaluated corrective saccade, the display position of the fixation object is adjusted so that the display position corrects the expected corrective saccade in the next trial in which the visual stimulus is switched again from one eye, e.g., the left eye, to the other eye, e.g., the right eye. During the first gaze direction block, the goal is to adjust the display positions of the fixation objects of the left and right eyes so that the corrective saccade is corrected in either switch direction. This adjustment of the display position of the fixation object is repeated in the same manner in the subsequent gaze direction blocks.

[0214] Typically, nine viewing positions are selected from a 3 × 3 matrix centered on the primary gaze direction (i.e., directly ahead, 0,0). Each selected viewing position is a combination of one of three horizontal gaze directions selected from the tuple [-α,0°,+α], where α lies in the range 10°–25°, and one of three vertical gaze directions selected from the tuple [-β,0°,+β], where β lies in the range 10°–25°.

[0215] According to another embodiment, as described above, depending on the assessed corrective saccade, the display position of the fixation object displayed to the right eye is adjusted, while the display position of the fixation object displayed to the left eye is not changed. Once a correction of the corrective saccade of the right eye is achieved, the display position of the left eye is adjusted, while the display position of the fixation object displayed to the right side remains fixed.

[0216] The direction and amplitude (i.e., disparity) of the accommodated viewing position relative to the unaccommodated viewing position allows for the quantification of the strabismus angle. Furthermore, the strabismus angle can be determined in relation to the magnitude of its vertical, horizontal, or torsion, depending on the choice of the accommodated viewing position of the fixation object.

[0217] In this embodiment, (R)APD and strabismus angle can be determined using one trial session with one type of visual stimulus, thus integrating two different tests into one test series, thereby reducing the time required to establish two functional eye parameters.

[0218] Both embodiments for determining the strabismus angle have in common that they determine the total angle of phoria (i.e. the strabismus angle) for each viewing position, i.e. gaze direction. For each of the nine viewing positions, the strabismus angles, in particular the horizontal strabismus angle and the vertical strabismus angle, are calculated, where for the situation where the right eye fixates the fixation object, the strabismus angle is determined for the left eye and vice versa, i.e. for the situation where the left eye fixates the fixation object, the strabismus angle is determined for the left eye.

[0219] Thus, during the first trial session, nine gaze direction blocks are carried out, during which the first type of stimuli are alternated between the right and left eyes as described for the determination of the APD, while in each gaze direction block the fixation object is displayed in one of the display positions selected and specifically adjusted so that the strabismus angle is determined.

[0220] Determining the field of view With reference to FIG. 4, in accordance with the present invention, the method allows for determining the subject's visual field 400 (see FIG. 4A) simultaneously with determining the strabismus angle.

[0221] For this purpose, in a second trial session, the subject is presented with a second type of visual stimulus. It should be noted that the second trial session may be performed before or after the first trial session, or even instead of the first trial session.

[0222] The second type of stimuli comprises luminance objects, which are compact, ie spatially limited and localized objects that can be displayed on a display system.

[0223] A second type of stimulus consists of a uniform background, in particular a black background, on which luminance objects are displayed.

[0224] The second type of stimulus is adjustable in terms of the luminance object and its luminance on the display system. Furthermore, the relative position of the luminance object (also called relative display position in the context of this specification) can be adjusted so that the luminance object is displayed at a selected position in the subject's field of view. The position at which the luminance object is displayed on the display system is therefore dependent on the subject's gaze direction. Said relative position is a position given relative to the current gaze direction of the eyes. The relative display position is therefore also called gaze-centered display since the current gaze direction 403 determines the origin of the display position.

[0225] Thus, to display luminance at a particular relative position, two criteria must be met for that relative position to be perceptible to the subject: a) The display position of the relative position of the luminance object must be within the limitations of the display system, otherwise the luminance object cannot be displayed. b) The display position of the relative position of the luminance object must be within the range of the eye tracking system, otherwise eye position or pupil size cannot be determined.

[0226] To assess the subject's visual field 400, a map of the subject's visual field is generated, which contains spatially resolved information on the threshold (see FIG. 4A in the form of grey values ​​indicating the perception threshold in the visual field map; the darker the lower the perception threshold), below which the subject does not perceive a luminance object if its luminance is below said threshold at the relative position where the test is performed. This approach is also called threshold perimetry. Thus, the subject's visual field is determined using the threshold perimetry method, and a visual field map 401 is obtained.

[0227] To generate said map 401, a threshold is determined for a number of different relative positions 402 distributed over the field of view (see Figures 4A and 4B).

[0228] A trial to determine the visual field begins with the onset of a second type of stimulus 403 having a luminance object displayed at a selected one of the multiple relative locations and ends approximately 500 milliseconds after an eye movement is made in the direction of the luminance object. Such a trial is classified as "seen" or deemed to be detected by the subject. If no eye movement is made in the direction of the stimulus within approximately 1000 milliseconds, the trial is classified as "not seen" or deemed not detected by the subject. In each trial, one of the multiple relative locations is tested.

[0229] For example, the luminance is 10 cd / m 2 The second type of visual stimulus consisted of a bright dot approximately 0.5° in diameter presented on a uniform background of 100 ms. The second type of visual stimulus was presented for a duration of 200 ms.

[0230] The luminance of the luminance object varies depending on the relative position of the luminance object and on whether or not a stimulus was deemed to be detected at that particular position in a preceding trial of the second trial session. Initially, the initial luminance of the luminance object is selected to be 2 dB higher than the age-corrected normal value for that relative position. If the stimulus is deemed to be detected after a trial, the luminance of the luminance object is subsequently reduced by 2 dB, but not in particular in subsequent trials. After a detected stimulus, the relative position of the luminance object is changed in the next trial. If the stimulus is deemed not to be recognized, i.e. not detected, the luminance of the luminance object is adaptively increased, for example by 2 dB to 10 dB, in particular by 2, 4, 6, 8, or 10 dB. This procedure is repeated until the threshold is exceeded once. Alternatively, the luminance of the luminance object can be adaptively increased or decreased, rather than by a fixed amount.

[0231] To determine the field of view, for example, 54 relative positions in the central field of the eye can be selectively examined. Luminance objects are displayed at relative positions so that positions near the nasal step, along the vertical meridian, and in the central field are over-represented. The relative positions cover a field of view with a diameter of 120°.

[0232] If a luminance object cannot be displayed at the selected relative position, e.g. due to limitations of the display system or the eye-tracking system, another of the eight relative positions is selected. If only relative positions already tested remain, a gaze reset procedure may be performed, during which a suprathreshold stimulus appears and the subject must follow it.

[0233] For this purpose, a suprathreshold stimulus appears in the current gaze direction / position. This stimulus can be in the form of a luminance object with suprathreshold luminance, for example, which may first be moved horizontally at 8° per second to a new horizontal position, followed by a vertical movement at 8° per second to a new vertical position.

[0234] Then, a luminance object (which may have a lower luminance) is displayed at the relative position that was previously out of range.

[0235] For each relative position, a perceptual threshold, also called threshold, is determined. Perceptual sensitivity is calculated for each relative position using the average of the least bright stimulus deemed to be detected and the most bright stimulus deemed not to be detected.

[0236] It may be advantageous to display a fixation object, in particular the fixation object during the second trial session, so that the subject can fixate his / her gaze on said fixation object. When the luminance object is displayed, a change in gaze position towards the luminance object is recorded (with a predetermined minimum speed of eye movement and a predetermined minimum directional accuracy), thereby indicating that the luminance object has been detected by the subject.

[0237] Determining smooth pursuit from gaze resetting procedures: Smooth pursuit can also be determined by evaluating eye movements in response to moving suprathreshold objects from the gaze reset procedure. For this purpose, recorded eye saccades are excluded from the smooth pursuit analysis. Right, left and vertical eye movements are separated. The average difference between the velocity of the eye movement and the velocity of the suprathreshold object movement, expressed as a percentage, can be defined as gain. A gain of 100% means that the eye movement perfectly tracks the suprathreshold object velocity.

[0238] fixation, gaze holding, square wave jerk, nystagmus Fixations can be determined during any trial session. In this analysis, smooth pursuit eye movements during gaze resetting and all saccades with amplitudes exceeding 3° are excluded. In particular, saccadic responses following newly presented stimuli are excluded.

[0239] Such fixation events are analyzed separately for five different relative positions in the central visual field: right gaze, left gaze, up gaze, down gaze, and main gaze.

[0240] Fixation stability corresponds to the number of changes in eye fixation while a suprathreshold object is continuously present on the screen, the numbers indicate the time spent within 3° of the suprathreshold stimulus and the number of fixation losses per minute (% of target).

[0241] Additionally or alternatively, the frequency of square wave eye movements may be determined during the first and / or second trial sessions. Square wave eye movements are defined as two horizontal saccades (outward and inward) of equal amplitude less than 5°±1°, separated by a time interval of 200 ms to 400 ms. The number of such events per minute is counted regardless of fixation, luminance, or the presence of suprathreshold objects.

[0242] Presence or absence of other (non-square-wave) saccadic intrusions: Any event involving consecutive saccades, i.e., two saccades with no intervening fixation event, is classified as a saccadic intrusion. As well as square-wave eye movements, double saccadic pulses, horizontal nystagmus, macrosaccadic oscillations, microsaccadic oscillations, and opsoclonus are identified.

[0243] Presence or absence of nystagmus: Nystagmus is defined as a drift in eye position of more than 1° per second in a constant direction for more than 5 seconds. The average velocity of the slow phase is used as the magnitude of the nystagmus. This is determined in each of the five patient-centered gaze positions / directions, i.e., relative positions.

[0244] Gaze holding function: Only data for right gaze, left gaze, up gaze, and down gaze are included. Similar to nystagmus detection, it determines whether or not there is an eye movement drift in the opposite direction to the gaze position / direction (e.g., pupil drift downward during up gaze, right drift during left gaze, etc.). If drift is present, the gaze holding is deemed abnormal. Drift is quantified using the same algorithm as nystagmus.

[0245] It is noted that all these parameters can be assessed during a single trial session, dramatically reducing measurement times.

[0246] Determining saccade accuracy Additionally, saccade accuracy can be determined from the sequence of second type stimuli simultaneously for each strabismus angle and visual field of the subject from any session. Only subsequent second type stimuli that are deemed detected and displayed at different relative positions are selected for analysis by the computer to determine saccade accuracy. This selection can also be performed automatically by the computer.

[0247] The first saccade that exceeds 3° in the direction of the relative position of the luminance object (±20°) is used for analysis. The difference (percentage) between the distance between the relative position of the subsequent second stimulus and the magnitude of the first saccade is calculated. This difference corresponds to the saccade accuracy.

[0248] Saccade accuracy is determined separately for rightward, leftward, and vertical saccades.

[0249] For each of the three types of saccades, the median error (percentage of the target amplitude) can be calculated and the number (percentage) of measured oversaccades can be calculated, the latter being defined as saccades with an amplitude exceeding 10% of the target amplitude.

[0250] Because large saccades are physiologically underscaled in the variance of saccade accuracy determination, the above numbers are corrected for target amplitude: an amplitude-dependent average age-correlated underscale is subtracted from each trial.

[0251] Peak velocity determination To determine peak velocity, saccadic eye movements are analyzed, particularly from data recorded during the second trial session, and the peak velocity of eye movement during the saccade is determined. Even if the saccade is shorter than 1 second, the peak velocity can be expressed in degrees / second. In further or alternative embodiments, saccades recorded during the first, third, or fourth trial sessions are analyzed for peak velocity in the same manner.

[0252] Determination of fusion width To determine the fusional width, a third trial session needs to be run on the system, where the third trial session comprises a third type of visual stimuli presented simultaneously to the subject's left and right eyes by the optical system.

[0253] Therefore, in addition to the first and second trials, a third type of stimulus needs to be presented to the subject.

[0254] Fusion width is determined from the binocular gaze directions recorded during the third trial session.

[0255] A third type of stimuli comprises an image or any structured object that can be focused.

[0256] This image is displayed to the subject with increasing disparity, in particular with continuously increasing disparity, while an eye-tracking system records the gaze direction of both eyes. To be able to compensate for the image disparity, the eyes are expected to perform a vergence movement.

[0257] The disparity of the images increases until the subject can no longer perform a convergence movement of the eyes and the gaze direction of the eyes switches back to an essentially straight or natural gaze direction.

[0258] The fusional width corresponds to the maximum disparity of the image presented to the subject for which the subject is still able to adjust the gaze direction of the eyes with the necessary vergence to compensate for the disparity.

[0259] The fusional width can be determined along the horizontal, vertical, and / or other directions. The fusional width can be given as the maximum convergence angle between the eyes.

[0260] Determining visual acuity To determine visual acuity, a fourth trial session may be performed, as illustrated below by an exemplary embodiment of the fourth trial session.

[0261] However, as noted above, visual acuity may be determined independent of the first, second and / or third trial sessions. Also, it is not necessary to perform a third trial in order to perform a fourth trial. The numbering of the trial sessions is provided solely as a means to distinguish between the various trial sessions that may be performed in accordance with the present invention. It does not in any way imply an order in which these trial sessions should be performed.

[0262] Thus, the fourth trial session may be performed before or after any of the first, second, or third trial sessions.

[0263] The fourth trial session includes a plurality of fourth type visual stimuli that are presented during different trials to the subject's left and right eyes using the optical system. Preferably, the Gabor patches 501 are presented separately to the left and right eyes such that the visual acuity is determined separately for each eye.

[0264] Each fourth type of stimulus includes a number of Gabor patches 501, which are displayed to the subject on a display system, preferably in an irregular pattern. On average, these Gabor patches should cover about 10%-30% of the display area of ​​the display system, while the minimum distance between them should be twice the diameter of a Gabor patch.

[0265] These Gabor patches may be displayed on a uniform, in particular grey, background, and these Gabor patches 501 are displayed by lighter and darker areas on said background.

[0266] Multiple Gabor patches are presented simultaneously in each fourth type of stimulus. In each trial, these Gabor patches 501 have identical properties except for their location on the display system.

[0267] Gabor patches can be characterized by their size and shape: they are defined by a Gaussian kernel function with variance, in particular isotropic variance, such that the Gabor patch appears as a circular object, modulated by a sinusoidal plane wave with a given orientation and a given period / spatial frequency.

[0268] For example, the period of a sinusoidal plane wave may be in the range of single and triple dispersion, but other frequencies may be chosen.

[0269] Furthermore, the sinusoidal plane wave may be centered with the maximum amplitude at the mean value location of the Gaussian kernel function.

[0270] The ratio of the variance of the Gaussian kernel and the period of the sinusoidal plane wave of the Gabor patch can be constant, which allows Gabor patches of different sizes to be displayed during different trials, and the appearance of the Gabor patch can grow or shrink while remaining essentially the same.

[0271] To determine visual acuity, a Gabor patch of initial size is moved back and forth on the display system along a predefined trajectory (502), where an eye tracking system records the eye movements (503) of the eye on which the Gabor patch is displayed.

[0272] The predefined trajectory may be a linear, i.e., unidirectional, movement with a sinusoidal velocity profile (502) that is the same for all displayed Gabor patches. For example, the trajectory may include 2-3 periods of sinusoidal motion until a new trial is performed, e.g., with a smaller or larger Gabor patch. The maximum velocity during the sinusoidal motion shall not exceed 20° / s, in particular shall not exceed 10° / s.

[0273] The eye is expected to follow this trajectory as long as the Gabor patch 501 is perceived.

[0274] In the evaluation step, the eye movements are filtered for any saccadic movements and only non-saccadic eye movements (503) are analyzed for visual acuity. The filtered eye movements and the Gabor patch movements are compared in terms of correlation and delay. If the subject perceives the Gabor patch, both movements should be approximately the same, but if the subject does not perceive the Gabor patch, for example because the size of the Gabor patch is too small, the eye movements will not be sufficiently correlated or will be significantly delayed with respect to the Gabor patch movements. In FIG. 5B, the subject is able to follow the Gabor patch, as can be seen by comparing the Gabor patch movements 502 to the eye movements 503.

[0275] Typically, visual acuity is estimated by an eye chart (e.g., "Landolt C"), but in this embodiment, visual acuity can alternatively be determined by moving Gabor patches. Gabor patches are essentially small patches of stripes, and therefore also subject to Moire effects or interference. However, because Gabor patches are relatively small, they also have a smaller effect of interference on the display. In contrast, if a stripe pattern is chosen that covers the entire screen, the intended stripes displayed by individual pixels of the screen may cause such effects, and the displayed stripes may appear much larger than intended. This would not happen with Gabor patches.

[0276] 6 shows a schematic diagram of an exemplary embodiment of a system 1 according to the present invention. System 1 includes an external computer 2 connected to a display system 4, an eye tracking system 5, an optical system 3 comprising a lens assembly 6, and a fixation mechanism 7 for mounting the optical system 3 to a subject's head 8. In another embodiment, the optical system may be included in a device arranged and configured to be placed in front of the subject's eyes, such that a fixation mechanism is required.

[0277] Furthermore, the optical system comprises a transmitting device 8 for wirelessly transmitting the recorded data to an external computer. The transmitting device 8 is also configured to receive instructions from the external computer 2 so that the external computer 2 can control the optical system 3. The optical system 3 may comprise a non-transitory memory storage (not shown) for storing computer program instructions and the recorded data. Furthermore, the optical system 3 may further comprise a processor (not shown) configured to execute the computer program stored in the memory storage. The processor is further configured to be controlled by the external computer 2, i.e. to receive instructions from the external computer 2, send confirmations and control the display system 4 as well as the eye-tracking system 5 of the optical system 3. This allows any trial session of the method according to the invention to be fully automated.

[0278] Optical system: The optical system 3 comprises a housing capable of forming a light-tight enclosed volume between the subject's eye and the display system 4 and containing the components of the optical system 3 .

[0279] Furthermore, the optical system 3 comprises a lens assembly 6 for adjusting the refractive power and correcting the optical aberrations of the subject. The lens assembly 6 is adjustable in terms of its refractive power and virtual distance correction of the displayed stimuli or images. For this purpose, the lens assembly 6 may comprise a spherical lens and a cylindrical lens. The eye tracking system 5 may consist of two cameras, each constructed and arranged to record one eye of the subject. These cameras are for example infrared cameras. The display system 4 comprises two displays or display parts, one for each eye.

[0280] The data recorded by the eye tracking system 5 is stored in a memory of the optical system 3 so that it can be correlated in time with the stimuli presented to the human eye.

[0281] External computer: The external computer 2 may be a conventional computer configured to receive user input and display data on a display of the computer 2. The computer 2 also includes a transmitting device for transmitting and receiving information in a wireless manner. The external computer 2 may be connected to the optical system 3 via the transmitting device.

Claims

1. A computer program for causing a system to execute a method for determining a plurality of functional eye parameters when the computer program is executed on a computer, the system comprising: an optical system (3) comprising a display system (4) configured to project visual stimuli independently onto the left and right eyes of a subject; a fixation tracking system (5) configured to record the fixation directions (100) and pupil sizes (102) of the left and right eyes; and the computer (2) configured to control the optical system (3) and receive data recorded from the fixation tracking system (5). The afferent pupillary defect (APD), particularly the relative afferent pupillary defect (RAPD), is determined from a first trial session consisting of a sequence of first type of stimuli presented to the left and right eyes of the subject by the display system (4), and the visual field (400) is determined from a second trial session consisting of a sequence of second type of stimuli presented to the left and right eyes of the subject by the display system (4), and the skew is also determined by determining one or more skew angles from the first trial session and / or the second trial session. The computer program.

2. The execution of the first trial session comprises the following steps: - recording data including information on the pupil size (102) and fixation direction (100) during the first trial session; - determining the APD by analyzing, by the computer (2), the time course (103) of the pupil sizes (102) of the left and right eyes from the recorded data of the first trial session; - determining one or more skew angles by analyzing, by the computer (2), the magnitude and direction of the saccadic eye movements (101) from the recorded fixation directions (100) of the first trial session. The computer program according to claim 1, comprising the above steps.

3. The execution of the second trial session comprises the following steps: - recording data including information on the fixation direction (100) of the subject; - Determining the visual field (400) and the one or more perspective angles by analyzing the recorded fixation directions (100) of the second trial session for saccadic eye movements of the subject by means of a computer (2); A computer program according to claim 1 or 2, comprising this step.

4. Each visual stimulus of the first type of visual stimulus comprises a fixation object (11) displayed on the display system (4) at the display position of the display system (4), and the fixation object (11) is a spatially limited graphical object that enables fixation of the eyes on the fixation object (11). A computer program according to any one of claims 1 to 3.

5. The first type of visual stimulus is repeatedly displayed alternately for the right and left eyes, and the pupil size (102) and the fixation direction (100) are recorded for both eyes. A computer program according to claim 4.

6. The first trial session comprises a plurality of fixation direction blocks, and in each fixation direction block, the first type of visual stimulus is repeatedly presented alternately to the right and left eyes, and the fixation object is displayed at different display positions for different fixation direction blocks. A computer program according to claim 5.

7. The fixation object (11) is displayed at the same display position for the same fixation direction block, and the magnitude and direction of the saccadic eye movement (101) are determined from the recorded saccadic eye movement each time the first type of stimulus switches from the left eye to the right eye or vice versa, so that the at least one perspective angle is determined in relation to the fixation direction. The at least one perspective angle is determined for each fixation direction block. A computer program according to claim 6.

8. For each presented first type of stimulus and in each fixation direction block for each eye, the magnitude and direction of the saccadic eye movement (101) are determined, and in a subsequent presentation of the first type of visual stimulus (11) in the same fixation direction block, the display position of the fixation object is adjusted so as to compensate for the magnitude and direction of the saccadic eye movement (101) determined from the previously presented first type of stimulus in the fixation direction block. A computer program according to claim 6.

9. Each visual stimulus of the second type of visual stimulus comprises a luminance object displayed on a uniform background at a relative position on the display system (4). During the second trial session, the luminance objects of the second type of visual stimulus are sequentially displayed at a plurality of selected relative positions. The second type of visual stimulus is displayed alternately or sequentially to the right and left eyes. Each time the luminance object is displayed at the selected relative position (402), it is determined whether the subject detected the luminance object at the selected relative position (402). If the subject detected the luminance object, the luminance object is then displayed at a different selected relative position. The luminance object is displayed again at the selected relative position in a subsequent trial at a reduced luminance. If the subject did not detect the luminance object at the selected relative position, the luminance object is repeatedly displayed at the selected relative position with increased luminance until the subject detects the luminance object. Thereby, for each selected relative position, the luminance detection threshold of each eye of the subject is determined, and thereby the visual field (400) is determined in the form of a threshold perimetric measurement. The computer program according to any one of claims 1 to 8.

10. If a saccadic eye movement towards the displayed luminance object is recorded by the visual target tracking system within a first time interval during which the luminance object is displayed, the luminance object is considered to have been detected by the subject, and if no saccadic eye movement towards the luminance object is recorded by the visual target tracking system within a second time interval longer than the first time interval, the stimulation of the luminance object is considered not to have been detected by the subject. The computer program according to claim 9.

11. When the second type of stimulus switches from the left eye to the right eye or from the right eye to the left eye, and when the luminance object is considered to have been detected by both eyes, the at least one skew angle is determined for the selected relative position (402) from the saccadic eye movement, or the at least one skew angle is determined for the selected relative position by subtracting the fixation directions of the left and right eyes from each other. The computer program according to claim 10.

12. A fixation direction reset routine is executed, where the routine comprises the following steps: - A step of determining whether the selected relative display position is outside the physical tracking limit of the visual target tracking system or the physical display limit of the display system, and in the case of "Yes": - A step of presenting an object exceeding a threshold, such as the fixation object or the luminance object, having a luminance exceeding a luminance detection threshold in the current fixation direction of the eye; - A step of moving the object exceeding the threshold along an orbit at a predetermined horizontal and vertical speed to a new display position; - A step of executing the steps of the method of the previous embodiment at the selected relative position determined to be outside the physical tracking limit of the visual target tracking or the physical display limit before the fixation reset routine is executed; The computer program according to any one of claims 4, 9 to 11, comprising:

13. During the fixation reset routine, the object exceeding the threshold moves in a predetermined velocity pattern along the horizontal and vertical directions, and the deviation between the velocity of the detected eye movement following the object exceeding the threshold and the velocity pattern of the object exceeding the threshold is determined for the movement direction of each object exceeding the threshold, and from the deviation, the gain of the smooth pursuit eye movement is determined from the fixation reset routine. The computer program according to claim 12.

14. The functional eye parameters to be determined are: - The fusional amplitude of the subject; further comprising: To determine the fusional amplitude, the method includes the following steps: - A step of executing a third trial session, the third trial session comprising a third type of visual stimulus simultaneously presented to the left and right eyes of the subject using the optical system; - A step of recording data during the third trial session including information on the fixation direction; - A step of determining at least the fusional amplitude by analyzing, by the computer, the convergence eye movement of the subject in response to the third type of visual stimulus presented in the third trial session from the recorded fixation direction of the third trial session; The computer program according to any one of claims 1 to 13, further comprising:

15. The functional eye parameters to be determined are: - The visual acuity of the subject; further comprising: To determine the visual acuity, the method includes the following steps: - A step of performing a fourth trial session, wherein the fourth trial session includes a plurality of fourth types of visual stimuli (501) presented to the left eye and / or right eye of the subject using an optical system (4); - A step of recording data during the fourth trial session including information regarding the fixation direction; - A step of determining at least visual acuity by analyzing, by a computer (2), the movements of the left and right eyes of the subject in response to the presented fourth type of visual stimuli of the fourth trial session from the recorded data of the fourth trial session; The computer program according to any one of claims 1 to 14, further comprising.

16. An ophthalmoscope (1) comprising an optical system (2) comprising a display system (4) configured to project visual stimuli independently to the left and right eyes of a subject, a fixation tracking system (5) configured to record the fixation directions and pupil sizes of the left and right eyes, a computer (2) configured to control the optical system (2) and receive data recorded from the fixation tracking system (5), and program code stored in a computer (2) that executes the computer program according to any one of claims 1 to 15, wherein the optical system (2) and the fixation tracking system (5) are provided in a near-eye display such as a VR goggle, and the near-eye display further comprises an adjustable lens assembly (6) for each eye such that the optical aberration of each eye of the subject can be corrected by the lens assembly (6).

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