Antimicrobial ingredients

Abstract

The present invention relates to methods and compositions that can be applied in personal cleaning, oral care, deodorant and hard surface cleaning applications, including liquid soaps, foam soaps, liquid dishwashing detergents, shower gels, shampoos, emulsified deodorants, mouthwashes, dentifrices and facial cleansers, to reduce or eliminate microorganisms on surfaces or body parts.

Description

[Technical field]

[0001] FIELD OF THEINVENTION The present invention relates to methods and compositions for human or animal body surface and hair cleaning applications, soft and porous substrates such as fabrics or hard surfaces cleaning applications, deodorant, oral care, or air care applications to reduce or remove microorganisms.

[0002] background Perfume ingredients can have antibacterial activity. However, the antibacterial activity of perfume ingredients can be greatly affected by the application base, especially surfactant bases, such as liquid soaps or shampoos. In these bases, perfume ingredients are incorporated into surfactant micelles, and the bioavailability of perfume ingredients is greatly reduced. Thus, rather high concentrations of perfume ingredients are required, which are unacceptable in terms of sensory impact, cost, and solubility issues. These obstacles are overcome by the compositions, methods, and uses of the present invention.

[0003] Summary of the Invention The invention includes methods and antimicrobial compositions comprising a fragrance ingredient, a surfactant, and a hydrotrope, the fragrance ingredient having a germicidal effect in ethanol solution of 5.5 log reduction at a concentration of 0.1% or less in ethanol solution.

[0004] In an embodiment of the invention, the perfume ingredients are 1-phenylethyl acetate, 1-octanol, (1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol, undecanal, (2E)-2-methyl-3-phenyl-2-propenal, (Z)-2-nonenal, 1-(5-propyl-1,3-benzodioxol-2-yl)ethenone, (2E,6Z)-2,6-nonadien-1-ol, ethyl benzoate, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, benzyl butyrate, 1-butoxycarbonylethyl butanoate. , Ethyl hexanoate, 5-isopropyl-2-methylphenol, (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, methyl (2E)-2-methyl-2-hexenoate, ethyl (E)-3-phenyl-propenoate, methyl (E)-3-phenyl-2-propenoate, (Z)-3,7-dimethyl-2,6-octadienal, (E)-3,7-dimethyl-2,6-octadienal, 3,5,5-trimethyl-1-hexenoate Sanol, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, (2E)-2-ethyl-4-[2,2,3-trimethyl-3-cyclopenten-1-yl]-2-buten-1-ol, 4-decanolide, (Z)-4-decenal, 2-methoxy-4-propylphenol, 2,6-dimethyl-7-octen-4-one, 2,6-dimethyl-4-heptanol, (E)-3,7-dimethyl-2,6-octadien-1-ol, 2,4,6-trimethyl-3-cyclohexen-1-methanol, 2-methoxy-4-[(1E)-1-propyl propen-1-yl]phenol, (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol, 2,5-dimethyl-2-indanethanol, 1,2-dimethoxy-4[(1Z)-1-propen-1-yl]benzene, 1,2-dimethoxy-4-[(1E)-1-propen-1-yl]benzene, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, (2,2-dimethyl-3-[(2Z)-3-methyl-2,4-pentadien-1-yl]oxirane, (2,2-dimethyl-3-[(2E)-3-methyl-2,4-Pentadien-1-yl]oxirane, 2-ethyl-1-hexanol, (Z)-3,7-dimethyl-2,6-octadien-1-ol, 1-(3-methyl-1-benzofuran-2-yl)ethenon, (Z)-6-nonen-1-ol, (2E,6Z)-2,6-nonadienal, 1,8-p-menthadien-7-ol, 3-methyl-5-phenyl-1-pentanol, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde, ethyl 2-hydroxybenzoate, 2-(5,5,6-trimethylbicyclo[2.2.1]heteroaryl)-2-methyl-1-phenylpropane, 1-methyl-1-phenylpropane, 1-methyl-2 ... 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 3-methylindole, 8-mercapto-3-p-menthanone, 3,7-dimethyl-3-octanol, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl Pyr-4-methylbicyclo[3.1.0]hexan-3-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one, thymol, 6-hexyltetrahydro-2H-pyran-2-one, 3-propylphenol, 2-cyclohexylethyl acetate, octanal, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, 5-heptyldihydro-2(3H)-furanone, 3-butylidene-1-benzo[c]furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-di Methyl-6-octenenitrile, Coriander Oil, Cyclopropyl Methyl (3Z)-3-Hexenoate, Cyclopropyl Methyl (3E)-3-Hexenoate, 3,7-Dimethyl-1-Octen-3-ol, Cinnamon Leaf Oil, 4-Decanolide, 3,5,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, 2,4,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, Lavandin Sumiensis Essential Oil, Peppermint Oil, 3,6,7-Trimethyl-2,6-Octadienal, Petitgrain Paraguay Essential Oil, (2Z)-4,8-Dimethyl-2,7-nonadiene-4-ol or a combination thereof.

[0005] In a further embodiment of the invention, the perfume ingredient is (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-6- Octen-1-ol, (2Z)-4,8-dimethyl-2,7-nonadien-4-ol, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, (Z)-4-decenal, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, undecanal, (2E)-2-ethyl-4-[2,2,3-trimethyl- 3-cyclopenten-1-yl]-2-buten-1-ol, 3,7-dimethyl-3-octanol, 2-(5,5,6-trimethylbicyclo[2.1.1]hept-2-yl)-1-cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-cyclohexylethyl acetate, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one or combinations thereof.

[0006] In an embodiment of the invention, the perfume ingredient is cyclopropyl methyl (3Z)-3-hexenoate or cyclopropyl methyl (3E)-3-hexenoate, 3,6,7-trimethyl-2,6-octadienal, (2Z)-4,8-dimethyl-2,7-nonadien-4-ol, octanal, 5-heptyldihydro-2(3H)-furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-1-octen-3-ol, cinnamon leaf oil, lavandinium smeane essential oil, 2-cyclohexylethyl acetate, peppermint oil, coriander oil, petitgrain paraguay essential oil, 3-butylidene-1-benzo[C]furanone or combinations thereof.

[0007] The fragrance ingredients in the compositions of the present invention may be present in an amount effective to provide an antimicrobial benefit.

[0008] In an embodiment of the invention, the fragrance ingredient is at least 0.001% (w / v) of the antimicrobial composition.

[0009] The surfactant may be 0.1%-30% (w / w) of the antimicrobial composition. In certain embodiments, the surfactant is 0.1%-20% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 0.1%-10% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-30% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-20% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-10% (w / w) of the antimicrobial composition.

[0010] The surfactant of the present invention can be an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, or a combination thereof.

[0011] The anionic surfactant may be, for example, sodium lauryl ether sulfate, and the amphoteric surfactant may be cocamidopropyl betaine. The nonionic surfactant may be an alkyl polyglycoside. The nonionic surfactant according to the present invention may be coco glucoside.

[0012] In an embodiment of the present invention, the antimicrobial composition may further comprise a hydrotrope. In a further embodiment, the antimicrobial composition comprises an additional agent having activity against gram-positive or gram-negative bacteria. In another embodiment, the antimicrobial composition may further comprise a chelating agent selected from the group consisting of EDTA and CDTA, and combinations thereof.

[0013] The antimicrobial composition of the present invention further comprises a hydrotrope.

[0014] In an embodiment of the invention, the hydrotrope is toluene sulfonate, xylene sulfonate, cumene sulfonate, diisobutyl sulfosuccinate, or a combination thereof. In a further embodiment, the hydrotrope is a sodium, ammonium, or potassium salt of a hydrotrope selected from toluene sulfonate, xylene sulfonate, cumene sulfonate, diisobutyl sulfosuccinate, sodium salicylate, sodium acetate, and sodium benzoate; dipropylene glycol n-butyl ether; or a combination thereof.

[0015] In an embodiment of the invention, the antimicrobial fragrance contains at least 25% (w / v) of the perfume ingredient, i.e. the perfume ingredient having a germicidal effect represents at least 25% (w / v) of the total fragrance mixture added to the composition.

[0016] In aspects of the invention, the compositions are preferably used to reduce or eliminate microorganisms on external surfaces of the human or animal body or on soft, porous substrates such as fabrics, or for hard surfaces, or for deodorant, air care, oral care and hair care applications.

[0017] The present invention encompasses consumer products that include the antimicrobial compositions according to the present invention and are hair care products, body care products, skin care products, oral care products, feminine care products, home care products, laundry care products, or body cleansing products, such as, but not limited to, shampoos, shower gels, facial cleansers, shaving gels, liquid hand soaps, foam soaps, hand sanitizers, soap bars, mouthwashes, dentifrices, feminine hygiene compositions, fabric cleansers, carpet cleansers, all-purpose cleansers, dish washing detergents, fresh goods detergents, deodorants, air fresheners, and air disinfectants.

[0018] The present invention includes a method of eliminating and / or reducing the number of microorganisms on a surface or body part comprising contacting the surface or body part with an antimicrobial composition of the present invention.

[0019] Additionally, the present invention includes the use of the antimicrobial compositions of the present invention to eliminate or reduce the number of microorganisms on a surface or body part.

[0020] In an embodiment of the present invention, the antimicrobial composition may be combined with a malodor counteracting system.

[0021] The malodor counteracting system comprises (a) (i) at least one aldehyde of formula R1CHO, where R1 is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing from 1 to 12 carbon atoms, (ii) at least one ketone of formula R2COR3, where R2 is an ethyl or methyl group and R3 is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing from 1 to 12 carbon atoms, and (iii) at least one ketone of formula R4CH2OH, where R4 is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing from 1 to 12 carbon atoms, optionally substituted with an aromatic moiety. (E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, (E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (E)-1-(2,2-dimethyl-6-methylenecyclohexyl)-2-buten-1-one, (E)-1-(2,6,6-trimethyl-1-cyclohexen-1- ... 1-(5,5-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one, (+-)-methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate, α- or β-(E)-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one (α- or β-ionone), (1E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-penten-3-one, ( at least one component selected from the group consisting of 1E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1-penten-3-one, (E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one gamma-methyl-ionone, 1-(2,6,6-trimethyl-1(2)-cyclohexen-1-yl)-1,6-heptadien-3-one and 1-(4,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one;and (ii) a composition comprising at least one nitrile component selected from the group consisting of 3-phenyl-2-propenenitrile, (E / Z)-3-methyl-5-phenyl-2-pentenenitrile citronellylnitrile, 3,7-dimethyl-6-octenenitrile citronellylnitrile, 2-propyl-1-heptanenitrile, dodecanenitrile, and a mixture of 3-(2,3-dimethyl-2(3)-cyclopenten-1-yl)butanenitrile and 3-(2-methyl-3-methylene-1-cyclopentyl)butanenitrile; and c) a combination of a) and b).

[0022] The antibacterial composition of the present invention can be combined with a malodor antagonist system.In an embodiment of the present invention, the antibacterial composition can be combined with at least one compound that inhibits the activity of at least one olfactory receptor selected from the group consisting of DMTS olfactory receptor, indole / skatole olfactory receptor, butyric acid olfactory receptor, and p-cresol olfactory receptor. The at least one compound that inhibits the activity of at least one olfactory receptor is selected from the group consisting of benzyl acetate, (1R,2R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl acetate (isobornyl acetate), undec-10-enal, undec-9-enal, cedarwood virginia essential oil, 3,7-dimethyl-2,6-octadienal, 3,7-dimethyl-6-octen-1-ol, 3,7-dimethyloct-6-enenitrile, coumarin, (E)-1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-butene-1 -one, (E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one methyl ionone gamma, (Z)-3,4,5,6,6-pentamethylhept-3-en-2-one, 2,6-dimethylhept-5-enal, menthone, 1-(5,5-dimethyl-1-cyclohexenyl)pent-4-en-1-one, patchouli essential oil, 2,6-nonadienal, (2-tert-butylcyclohexyl)acetate, 2-methyl-3-hexanone oxime (vertoxime), or 2-methoxynaphthalene.

[0023] Detailed Description In accordance with the present invention, there is provided a method and antimicrobial composition comprising a fragrance ingredient, a surfactant, and a hydrotrope, wherein the fragrance ingredient has a germicidal effect of 5.5 log reduction relative to an ethanol solution at an ethanol concentration of 0.1% or less.

[0024] As used herein, "perfume ingredient" means a compound capable of imparting or modifying the odor of a composition in a pleasant or positive way. In general, perfume ingredients may belong to various chemical classes such as alcohols, lactones, aldehydes, ketones, esters, ethers, acetates, nitriles, terpenoids, nitrogen- or sulfur-containing heterocyclic compounds and essential oils.

[0025] Another subject of the present invention is a perfuming composition comprising at least one ingredient selected from the group consisting of perfuming co-ingredients, perfume carriers and mixtures thereof, and optionally at least one perfume adjuvant.

[0026] The liquid perfume carrier may include, as a non-limiting example, a solubilizer or solvent commonly used in perfumery. A detailed description of the nature and type of solvent commonly used in perfumery cannot be exhaustive. However, as a non-limiting example, it may include solvents such as dipropylene glycol, diethyl phthalate, isopropyl myristate, benzyl benzoate, 2-(2-ethoxyethoxy)-1-ethanol or ethyl citrate, which are the most commonly used. In the case of a composition that includes both a perfume carrier and a perfume co-ingredient, suitable perfume carriers other than those specified above may be ethanol, limonene or other terpenes, isoparaffins, such as those known under the trademark Isopar® (manufacturer: Exxon Chemical), or glycol ethers and glycol ether esters, such as those known under the trademark Dowanol® (manufacturer: Dow Chemical Company). By "perfume co-ingredient" herein is meant a compound that is used in perfume preparations or compositions to impart a hedonic effect, and is not a microcapsule as defined above. In other words, such auxiliary ingredients to be considered perfuming ingredients must be recognized by those skilled in the art not simply as having an odor, but as being able to impart or modify the odor of a composition in a positive or pleasant way.

[0027] Non-limiting examples include: Aldehyde components: decanal, dodecanal, 2-methyl-undecanal, 10-undecenal, octanal and / or nonenal; Aromatic herbal ingredients: eucalyptus oil, camphor, eucalyptol, menthol and / or alpha-pinene; · Balsamic ingredients: coumarin, ethyl vanillin, and / or vanillin; · Citrus ingredients: Dihydromyrcenol, 3,7-dimethylocta-2,6-dienal, orange oil, linalyl acetate, (-)-(R)-3,7-dimethyl-6-octenenitrile, orange terpenes, limonene, 1-P-menthen-8-yl acetate and / or 1,4(8)-P-menthadiene; Floral components: Methyl dihydrojasmonate, Linalool, Citronellol, Phenylethanol, 3-(4-tert-butylphenyl)-2-methylpropanal, Hexylcinnamaldehyde, Benzyl acetate, Benzyl salicylate, Tetrahydro-2-isobutyl-4-methyl-4(2H)-pyranol, β-Ionone, Methyl 2-(methylamino)benzoate, (E)-3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, Hexyl salicylate, 3,7-Dimethyl-1,6-nonadien-3-ol, 3-(4-Isopropylphenyl)-2-methylpropanal, Vergyl acetate, Geraniol, P-Menth-1-en-8-ol, 4-(1,1-Dimethylethyl)-1-cyclohexyl acetate, 1,1-Dimethylethyl 1-phenylethyl acetate, 4-cyclohexyl-2-methyl-2-butanol, amyl salicylate, high cis-methyl dihydrojasmonate, 3-methyl-5-phenyl-1-pentanol, vergyl propionate, geranyl acetate, tetrahydro-linalool, cis-7-p-menthanol, propyl (S)-2-(1,1-dimethylpropoxy)propanoate, 2-methoxynaphthalene, 2,2,2-trichloro-1-phenylethyl acetate, 4 / 3-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carbaldehyde, amyl cinnamaldehyde, 4-phenyl-2-butanone, isononyl acetate, 4-(1,1-dimethylethyl)-1-cyclohexyl acetate, vergyl isobutyrate and / or a mixture of methyl ionone isomers; · Fruity ingredients: gamma undecalactone, 4-decanolide, ethyl 2-methyl-pentanoate, hexyl acetate, ethyl 2-methylbutanoate, gamma nonalactone, allyl heptanoate, 2-phenoxyethyl isobutyrate, ethyl 2-methyl-1,3-dioxolane-2-acetate and / or diethyl 1,4-cyclohexanedicarboxylate; · Green ingredients: 2,4-dimethyl-3-cyclohexene-1-carbaldehyde, 2-tert-butyl-1-cyclohexyl acetate, (+-)-1-phenylethyl acetate, allyl (2-methylbutoxy)acetate, 4-methyl-3-decen-5-ol, diphenyl ether, (Z)-3-hexen-1-ol and / or 1-(5,5-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one; Musk ingredients: 1,4-dioxa-5,17-cycloheptadecanedione, pentadecenolide, 3-methyl-5-cyclopentadecen-1-one, 1,3,4,6,7,8-hexahydro-4,6,7,8,8-hexamethyl-cyclopenta-g-2-benzopyran, (1S,1'R)-2-[1-(3',3'-dimethyl-1'-cyclohexyl)ethoxy]-2-methylpropylpropanoate, pentadecanolide and / or (1S,1'R)-[1-(3',3'-dimethyl-1'-cyclohexyl)ethoxycarbonyl]methylpropanoate; Woody ingredients: 1-(octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-1-ethanone, patchouli oil, terpene fraction of patchouli oil, (1'R,E)-2-ethyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-2-buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, methyl cedryl ketone, 5-(2,2,3-trimethyl-3-cyclopentenyl)-3-methylpentan-2-ol, 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethan-1-one and / or isobornyl acetate; Other ingredients (e.g. amber, powdery-spicy or watery): Dodecahydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b]furan and any of its stereoisomers, heliotropin, anisaldehyde, eugenol, cinnamaldehyde, clove oil, 3-(1,3-benzodioxol-5-yl)-2-methylpropanal and / or 3-(3-isopropyl-1-phenyl)butanal.

[0028] The perfume ingredients are not limited to those mentioned above. The perfume ingredients can also be found in reference texts such as the book by S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, New Jersey, USA or its latest edition, or other treatises of a similar nature, and in patent literature in the perfumery field.

[0029] In a further embodiment of the invention, the perfume ingredient is selected from the group consisting of 1-phenylethyl acetate, 1-octanol, (1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol, undecanal, (2E)-2-methyl-3-phenyl-2-propenal, (Z)-2-nonenal, 1-(5-propyl-1,3-benzodioxol-2-yl)ethenone, (2E,6Z)-2,6-nonadien-1-ol, ethyl benzoate, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, benzyl butyrate, 1-butoxycarbonylethylbutanoate, 1-methylbutanol ... ester, ethyl hexanoate, 5-isopropyl-2-methylphenol, (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, methyl (2E)-2-methyl-2-hexenoate, ethyl (E)-3-phenyl-2-propenoate, methyl (E)-3-phenyl-2-propenoate, (Z)-3,7-dimethyl-2,6-octadienal, (E)-3,7-dimethyl-2,6-octadienal, 3,5,5-trimethyl-1 -Hexanol, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, (2E)-2-ethyl-4-[2,2,3-trimethyl-3-cyclopenten-1-yl]-2-buten-1-ol, 4-decanolide, (Z)-4-decenal, 2-methoxy-4-propylphenol, 2,6-dimethyl-7-octen-4-one, 2,6-dimethyl-4-heptanol, (E)-3,7-dimethyl-2,6-octadien-1-ol, 2,4,6-trimethyl-3-cyclohexen-1-methanol, 2-methoxy-4-[(1E)-1- propen-1-yl]phenol, (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol, 2,5-dimethyl-2-indanethanol, 1,2-dimethoxy-4[(1Z)-1-propen-1-yl]benzene, 1,2-dimethoxy-4-[(1E)-1-propen-1-yl]benzene, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, (2,2-dimethyl-3-[(2Z)-3-methyl-2,4-pentadien-1-yl]oxirane, (2,2-dimethyl-3-[(2E)-3-methyl-2,4-Pentadien-1-yl]oxirane, 2-ethyl-1-hexanol, (Z)-3,7-dimethyl-2,6-octadien-1-ol, 1-(3-methyl-1-benzofuran-2-yl)ethenon, (Z)-6-nonen-1-ol, (2E,6Z)-2,6-nonadienal, 1,8-p-menthadien-7-ol, 3-methyl-5-phenyl-1-pentanol, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde, ethyl 2-hydroxybenzoate, 2-(5,5,6-trimethylbicyclo[2.2.1]heteroaryl)-2-methyl-1-phenylpropane, 1-methyl-1-phenylpropane, 1-methyl-2 ... 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 3-methylindole, 8-mercapto-3-p-menthanone, 3,7-dimethyl-3-octanol, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one, thymol, 6-hexyltetrahydro-2H-pyran-2-one, 3-propylphenol, 2-cyclohexylethyl acetate, octanal, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, 5-heptyldihydro-2(3H)-furanone, 3-butylidene-1-benzo[c]furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-dihydro-2-methyl-4-methylbicyclo[3.1.0]hexan-3-one, ...1-isopropyl-4-methylbicyclo[3.1.0]hexan Methyl-6-octenenitrile, Coriander Oil, Cyclopropyl Methyl (3Z)-3-Hexenoate, Cyclopropyl Methyl (3E)-3-Hexenoate, 3,7-Dimethyl-1-Octen-3-ol, Cinnamon Leaf Oil, 4-Decanolide, 3,5,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, 2,4,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, Lavandin Sumiensis Essential Oil, Peppermint Oil, 3,6,7-Trimethyl-2,6-Octadienal, Petitgrain Paraguay Essential Oil, (2Z)-4,8-Dimethyl-2,7-nonadiene-4-ol or a combination thereof.

[0030] In a further embodiment of the invention, the perfume ingredient is (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-6- Octen-1-ol, (2Z)-4,8-dimethyl-2,7-nonadien-4-ol, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, (Z)-4-decenal, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, undecanal, (2E)-2-ethyl-4-[2,2,3-trimethyl- 3-cyclopenten-1-yl]-2-buten-1-ol, 3,7-dimethyl-3-octanol, 2-(5,5,6-trimethylbicyclo[2.1.1]hept-2-yl)-1-cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-cyclohexylethyl acetate, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one or combinations thereof.

[0031] In an embodiment of the invention, the perfume ingredient is cyclopropyl methyl (3Z)-3-hexenoate or cyclopropyl methyl (3E)-3-hexenoate, 3,6,7-trimethyl-2,6-octadienal, (2Z)-4,8-dimethyl-2,7-nonadien-4-ol, octanal, 5-heptyldihydro-2(3H)-furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-1-octen-3-ol, cinnamon leaf oil, lavandinium smeane essential oil, 2-cyclohexylethyl acetate, peppermint oil, coriander oil, petitgrain paraguay essential oil, 3-butylidene-1-benzo[C]furanone or combinations thereof.

[0032] The flavor component may be at least 0.001% (w / v) of the antimicrobial composition. The flavor component of the present invention may be from about 0.001% to about 5.0% (w / v) of the antimicrobial composition. Preferably, the flavor component is from about 0.01% to about 5.0% w / v of the antimicrobial composition. More preferably, the flavor component is from about 0.05 to about 5.0% w / v of the antimicrobial composition. In a further embodiment, the flavor component is from about 0.1% to about 5.0% w / v of the antimicrobial composition.

[0033] The concentration of the fragrance ingredient for the 5.5 log reduction germicidal effect of the present invention can be 0.1% or less in ethanol solution.

[0034] As used herein, "hard surface" refers to any hard surface. Surfaces to be cleaned include kitchen and bathroom floors, walls, tiles, windows, cupboards, sinks, showers, plastic shower curtains, washstands, toilets, furniture fixtures, etc. made of different materials such as ceramic, vinyl, no-wax vinyl, linoleum, melamine, glass, steel, kitchen work surfaces, any plastic, plasticized wood, metal or any painted, varnished or sealed surface, etc. Household hard surfaces include, but are not limited to, household appliances, such as refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, etc. Such hard surfaces can be found both in private homes and in commercial, institutional and industrial environments.

[0035] As used herein, "body part" refers to any part of a mammalian body that is exposed to the external environment and includes skin and mucosal surfaces. Thus, for example, body parts include skin, oral mucosa, and teeth. In a preferred embodiment, the body part is a human body part.

[0036] The surfactant according to the present invention may be selected from the group of anionic, amphoteric, nonionic or cationic surfactants, but is not limited thereto.

[0037] Non-limiting examples of anionic surfactants include sodium, potassium, or ammonium salts of alkylsulfonates, fatty acid methyl ester sulfonates, alkylbenzenesulfonates, secondary alkane sulfonates, alpha olefin sulfonates, alcohol sulfates, alcohol ether sulfates, alcohol ether phosphates, sulfated alkanolamides, glyceride sulfates, fatty acids, dialkylsulfosuccinates, N-acyl-sarcosinates, N-acyl-taurates, acyl-isethionates, N-acyl-glutamates, N-acyl-glycinates, and N-acyl-alaninates.

[0038] Non-limiting examples of amphoteric surfactants include alkylbetaines, alkylamidopropylbetaines, alkylsulfobetaines, alkylamine oxides, lecithins (phospholipids) such as phosphatidylcholines, lysolecithin, alkyl-amphoacetates, and alkylamphodiacetates.

[0039] Non-limiting examples of nonionic surfactants include ethoxylated fatty alcohols, ethoxylated alkylphenols, ethoxylated thiols, mixed propoxylated and ethoxylated fatty alcohols, ethoxylated castor oil or hydrogenated castor oil, acid ethoxylated fatty acids, fatty esters of hexitols and cyclic anhydrohexitols (e.g., sorbitan), ethoxylated fatty esters of hexitols and cyclic anhydrohexitols (e.g., polysorbates), sugar esters, alkyl polyglycosides, polyglyceryl fatty acid esters, ethoxylated amines, ethoxylated amides, and alkyl diethanolamides.

[0040] The non-ionic surfactant may be selected from the group of water-soluble triblock copolymers containing blocks of polyethylene glycol and polypropylene glycol (sold under trade names such as Pluronic, Tetronic, Poloxamer, Syperonics, etc.).

[0041] The surfactant may also be selected from the group of natural biosurfactants including glycolipids (eg sophorolipids, mannosylerythritol lipids and rhamnolipids) and saponins.

[0042] The surfactant may also be selected from the group of cationic surfactants including alkyl quaternary ammonium salts, esterquats, linear alkyl-amines, amido-amines, ester-amines, or ethoxylated amines.

[0043] The surfactant may be used as a combination of the above surfactants.

[0044] In one embodiment, the anionic surfactant is sodium lauryl ether sulfate.

[0045] In another embodiment, the amphoteric surfactant is cocamidopropyl betaine.

[0046] In another embodiment, the non-ionic surfactant is coco-glucoside.

[0047] The surfactant may be 0.1% to 30% (w / w) of the antimicrobial composition. In certain embodiments, the surfactant of the present invention may be about 0.1 to about 20% w / w of the total weight of the antimicrobial composition. In further embodiments, the surfactant is about 1% to about 10% w / w of the total weight of the antimicrobial composition.

[0048] The surfactant may be 0.1%-30% (w / w) of the antimicrobial composition. In certain embodiments, the surfactant is 0.1%-20% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 0.1%-10% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-30% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-20% (w / w) of the antimicrobial composition. In further embodiments, the surfactant is 9.1%-10% (w / w) of the antimicrobial composition.

[0049] The antimicrobial compositions of the present invention further comprise a hydrotrope, a substance that does not by itself form microemulsions or lyotropic liquid crystals, but in whose presence hydrophobic compounds become more soluble in water.

[0050] The hydrotrope of the present invention can be from about 0.5 to about 20% w / w of the total weight of the antimicrobial composition, hi one embodiment, the hydrotrope is from about 1% to about 10% w / w of the total weight of the antimicrobial composition.

[0051] In preferred embodiments, the antimicrobial compositions of the present invention contain less than 4% (w / w) hydrotrope, less than 3% (w / w) hydrotrope, less than 2% (w / w) hydrotrope, less than 1% (w / w) hydrotrope or less.

[0052] In yet another preferred embodiment, the antimicrobial composition comprises a surfactant at 10% (w / w) or more of the antimicrobial composition, and then the hydrotrope is more than 4% (w / w) of the antimicrobial composition, preferably more than 5% (w / w) of the antimicrobial composition, preferably more than 6% (w / w) of the antimicrobial composition, preferably more than 7% (w / w) of the antimicrobial composition, preferably more than 10% (w / w) of the antimicrobial composition, preferably more than 15% (w / w) of the antimicrobial composition. The hydrotrope may be selected from the group of arylsulfonates. In a particular aspect, the hydrotrope is benzenesulfonate, toluenesulfonate, xylenesulfonate, cumenesulfonate, or combinations thereof, and the corresponding sodium, ammonium or potassium salt forms.

[0053] The hydrotrope may also be selected from the group of diisobutyl sulfosuccinate, diisopropyl sulfosuccinate, di-n-propyl sulfosuccinate, diethyl sulfosuccinate, or combinations thereof in the form of the corresponding sodium, ammonium or potassium salts.

[0054] The hydrotrope may be selected from the group of benzoates, salicylates, or butyl monoglycol sulfate in the form of the corresponding sodium, ammonium, or potassium salts.

[0055] The hydrotrope can be dipropylene glycol-n-butyl ether.

[0056] The hydrotrope can be catechol, resorcinol, pyrogallol, hydroquinone, or 4-methoxyphenol.

[0057] The hydrotrope may be selected from the group: benzyl alcohol, urea, nicotinamide.

[0058] The hydrotrope can be sodium benzoate or sodium acetate.

[0059] The hydrotrope may be a short chain (approximately C4) alkyl polyglycoside.

[0060] The hydrotrope may be used as a combination of the above mentioned hydrotropes.

[0061] Non-limiting examples of suitable hydrotropes include toluene-sulfonate, xylene-sulfonate, cumene-sulfonate, diisobutyl-sulfosuccinate, sodium salicylate, sodium acetate and sodium benzoate. The antimicrobial composition of the present invention may further comprise a solvent. According to an embodiment, the antimicrobial composition comprises a water-miscible co-solvent, preferably a water-miscible co-solvent selected in the group consisting of monohydric and polyhydric solvents. Non-limiting examples of such solvents can be found in the group comprising ethanol, n-propanol, propylene glycol, hexylene glycol, dipropylene glycol, glycerol, isopropylidene glycerol, butylene glycol (1,3-butanediol), 1,2-pentanediol, 1,2-hexanediol, 1,3-propanediol, and isopropanol and mixtures thereof. According to another embodiment, the water-miscible co-solvent is selected from the group consisting of triethyl citrate, triacetin, ethyl lactate, glycol ether.

[0062] The antimicrobial compositions of the present invention may further include optional ingredients such as colorants, preservatives, viscosity agents, opacifiers, emollients, humectants, antioxidants, gelling agents, gums, chelating agents, functional polymers, cellulose derivatives, essential oils, electrolytes, and pH adjusters.

[0063] The present invention encompasses consumer products including antimicrobial compositions, such as personal cleaning products, oral care products, deodorant products, hard surface cleaning products, liquid soaps, foam soaps, liquid detergents, shampoos, shower gels, facial cleansers, mouthwashes, and dentifrices.

[0064] The antibacterial composition according to the present invention may be active against gram-negative and gram-positive bacteria. In addition, the antibacterial composition according to the present invention may be active against the following bacteria: Escherichia coli, Salmonella sp., Pseudomonas aeruginosa, Pseudomonas fluorescens, Serratia marcescens, Klebsiella pneumoniae, Staphylococcus aureus, and Listeria monocytogenes, or combinations thereof.

[0065] The antibacterial compositions according to the invention may also be active against fungal species, particularly fungi of the Aspergillus, Penicillium, Cladosporium, and Candida species.

[0066] As will be appreciated by those skilled in the art, the above bacterial and fungal species can contribute to undesirable personal odors, clothing and household odors. In particular, Moraxella and Pseudomonas species of bacteria, and Cladosporium species of fungi, are well known to cause damp or moldy odors on fabrics and in laundry.

[0067] Thus, in a preferred embodiment of the present invention, the consumer product comprising the antimicrobial composition of the present invention is a cleaning product, preferably a laundry product, which reduces undesirable damp or moldy odors.

[0068] A further aspect of the present invention provides a method of removing and / or reducing musty odors from clothing comprising contacting the clothing with an antimicrobial composition of the present invention.

[0069] Odor antagonists The antibacterial composition of the present invention may be used in combination with a malodor antagonist system (e.g., in one composition or in separate compositions administered simultaneously or close in time). The malodorous compound may activate at least one olfactory receptor associated with malodor. Without intending to be limited to any particular theory, malodors are usually complex mixtures of more than one malodorous compound that may include various amines, thiols, sulfides, short chain aliphatic and unsaturated acids, such as fatty acids, and derivatives thereof. In one embodiment, the at least one olfactory receptor is an olfactory receptor disclosed in WO 2019 / 101821. In another embodiment, the at least one olfactory receptor is an olfactory receptor disclosed in WO 2018 / 091686. In another embodiment, the at least one olfactory receptor is an olfactory receptor disclosed in WO 2018 / 091686.

[0070] In one aspect, inhibition of at least one olfactory receptor inhibits, reduces or prevents the perception of malodour in a consumer.

[0071] As used herein, the terms "antagonist", "inhibitor", "blocker", "suppressor", "neutralizer" and "modulator" of olfactory receptors are used interchangeably to refer to molecules that inhibit, block, inhibit or regulate, such as ligands, antagonists, and their homologs and mimetics, identified using in vivo, ex vivo and in vitro assays for olfactory transduction. Inhibitors are, for example, compounds that bind, partially or completely block stimulation, reduce, inhibit, prevent, delay activation, inactivate, desensitize, or downregulate olfactory transduction, such as antagonists. Activators are, for example, compounds that bind, stimulate, increase, initiate, promote activation, enhance activation, sensitize, or upregulate olfactory transduction, such as agonists. Modulators include compounds that alter the interaction of extracellular proteins that bind activators or inhibitors (e.g., odorant-binding proteins, ebnerin and other members of the hydrophobic carrier family); G proteins; kinases (e.g., rhodopsin kinase and beta-adrenergic receptor kinase homologs involved in receptor inactivation and desensitization); and alesin with the receptor, which also inactivates and desensitizes the receptor.

[0072] The ability of the compounds and methods of the present disclosure to inhibit or antagonize at least one olfactory receptor can be determined by any suitable method readily selected by one of ordinary skill in the art, for example, by an in vitro cultured neuronal assay or by an in vitro assay using a cell line expressing the butyric acid olfactory receptor.

[0073] As used herein, the term "olfactory receptor" or "OR" refers to one or more members of a family of G protein-coupled receptors (GPCRs) expressed in olfactory cells. Olfactory receptor cells can also be identified based on morphology or by the expression of proteins that are specifically expressed in olfactory cells. OR family members can act as receptors for odorants and have the ability to induce the olfactory transduction cascade.

[0074] In one embodiment, the at least one compound that inhibits the activity of at least one olfactory receptor is selected from the group consisting of benzyl acetate, isobornyl acetate, undec-10-enal, undec-9-enal, cedarwood virginia essential oil, 3,7-dimethyl-2,6-octadienal, 3,7-dimethyl-6-octen-1-ol, 3,7-dimethylocten-6-enenitrile, coumarin, (2E)-1-(2,2-dimethyl-6-methylenehexyl) )-2-buten-1-one, methyl ionone gamma, (Z)-3,4,5,6,6-pentamethylhept-3-en-2-one, 2,6-dimethylhept-5-enal, menthone, 1-(5,5-dimethyl-1-cyclohexenyl)pent-4-en-1-one, patchouli essential oil, 2,6-nonadienal, (2-tert-butylcyclohexyl)acetate, vertoxime, and 2-methoxynaphthalene.

[0075] Other examples of compounds capable of inhibiting the activity of at least one olfactory receptor selected from the group consisting of the DMTS olfactory receptor, the indole / skatole olfactory receptor, the butyrate olfactory receptor, and the p-cresol olfactory receptor include the compounds disclosed in WO 2019 / 101821.

[0076] Further examples of other compounds capable of inhibiting the activity of at least one olfactory receptor selected from the group consisting of the DMTS olfactory receptor, the indole / skatole olfactory receptor, the butyrate olfactory receptor, and the p-cresol olfactory receptor include the compounds disclosed in International Patent Application Publication No. WO 2018 / 091686.

[0077] In one embodiment, the at least one compound capable of inhibiting the activity of the DMTS olfactory receptor may be selected from the compounds capable of inhibiting the activity of the DMTS olfactory receptor disclosed in International Patent Application Publication No. WO 2019 / 101821.

[0078] In one embodiment, the at least one compound capable of inhibiting the activity of the butyric acid olfactory receptor may be selected from the compounds capable of inhibiting the activity of the butyric acid olfactory receptor disclosed in International Patent Application Publication No. WO 2019 / 101821.

[0079] In one embodiment, the at least one compound capable of inhibiting the activity of the indole / skatole olfactory receptor may be selected from the compounds capable of inhibiting the activity of the indole / skatole olfactory receptor disclosed in International Patent Application Publication No. WO 2019 / 101821.

[0080] In one embodiment, the at least one compound capable of inhibiting the activity of the p-cresol olfactory receptor may be selected from the compounds capable of inhibiting the activity of the p-cresol olfactory receptor disclosed in International Patent Application Publication No. WO 2018 / 091686.

[0081] In one aspect the malodour antagonist system is present in the antimicrobial composition in an amount of 30-50% by weight of the antimicrobial composition.

[0082] In one aspect, the malodour antagonist system is present in the antimicrobial composition in an amount of 30-45% by weight of the antimicrobial composition, or alternatively in an amount of 30-40% by weight, or alternatively in an amount of 30-35% by weight.

[0083] In one aspect the malodour antagonist system is present in the antimicrobial composition in an amount of 35-50% by weight of the antimicrobial composition, or alternatively 40-50% by weight, or alternatively 45-50% by weight.

[0084] In one aspect the malodour antagonist system is present in the antimicrobial composition at 30%, or 35%, or 40%, or 45%, or 50% by weight of the antimicrobial composition.

[0085] Odor neutralizing system The antimicrobial compositions of the present invention may be used in combination with a malodor neutralizing system (e.g., in one composition or in separate compositions administered simultaneously or closely together). Malodor neutralizing systems limit, reduce, or eliminate the perception of malodor by reacting with various compounds that may cause malodor. The reaction results in a reduction in the airborne concentration of the malodorous material, which in turn reduces the perception of malodor.

[0086] In one embodiment, the at least one malodour counteracting system comprises a) a compound represented by the formula R 1 CHO (in the formula, R 1 is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms; (ii) at least one aldehyde of formula R 2 COR 3 (In the formula, R 2 is an ethyl or methyl group, and R 3 is an aliphatic linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms; and (iii) at least one ketone of formula R 4 CH2OH (wherein, R 4is an aliphatic linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms, optionally substituted with an aromatic moiety); b) a composition comprising at least one component selected from the group consisting of (i) (2E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, (2E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (2E)-1-(2,2-dimethyl-6-methylenecyclohexyl)-2-buten-1-one, ionone, (E)-1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one, 1-(5,5-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one, (+-)-methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate, α- or β-(E)-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one (α- or β-ionone), (1E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-penten at least one component selected from the group consisting of 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1-penten-3-one, (1E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1-penten-3-one, (E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, 1-(2,6,6-trimethyl-1(2)-cyclohexen-1-yl)-1,6-heptadien-3-one and 1-(4,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one; and (ii) 3- a) a composition comprising at least one nitrile component selected from the group consisting of phenyl-2-propenenitrile, (E / Z)-3-methyl-5-phenyl-2-pentenenitrile, 3,7-dimethyl-6-octenenitrile, 2-propyl-1-heptanenitrile, dodecanenitrile, and a mixture of 3-(2,3-dimethyl-2(3)-cyclopenten-1-yl)butanenitrile and 3-(2-methyl-3-methylene-1-cyclopentyl)butanenitrile; and c) a combination of a) and b).

[0087] (i) Formula R1 CHO (in the formula, R 1 is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms; (ii) at least one aldehyde of formula R 2 COR 3 (In the formula, R 2 is an ethyl or methyl group, and R 3 is an aliphatic linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms; and (iii) at least one ketone of formula R 4 CH2OH (wherein, R 4 Examples of compositions comprising at least one component selected from the group consisting of primary alcohols of the formula: (wherein m is an aliphatic, linear or branched, saturated or unsaturated carbon chain containing 1 to 12 carbon atoms, optionally substituted with an aromatic moiety) can be found in U.S. Pat. No. 8,772,354.

[0088] (i) (2E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, (2E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (2E)-1-(2,2-dimethyl-6-methylenecyclohexyl)-2-buten-1-one, (E)-1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one, 1-(5,5-dimethyl-1-cyclohexen-1- (1E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-penten-3-one, (+-)-methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate, α- or β-(E)-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one (α- or β-ionone), (1E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-penten-3-one, (1E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1- penten-3-one, (E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, 1-(2,6,6-trimethyl-1(2)-cyclohexen-1-yl)-1,6-heptadiene-3-one and 1-(4,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one; and (ii) 3-phenyl-2-propenenitrile, citro Examples of compositions comprising at least one component selected from the group consisting of nitriles, citronellyl nitrile, 2-propyl-1-heptanenitrile, dodecanenitrile, and at least one nitrile component selected from the group consisting of 3-(2,3-dimethyl-2(3)-cyclopenten-1-yl)butanenitrile and 3-(2-methyl-3-methylene-1-cyclopentyl)butanenitrile can be found in U.S. Patent Application Publication No. 2017 / 0266334.

[0089] In one embodiment, the at least one malodour counteracting system is present in the antimicrobial composition in an amount of from 5 to 20% by weight of the antimicrobial composition.

[0090] In one embodiment, the at least one malodour neutralising system is present in the antimicrobial composition in an amount of 5 to 19% by weight of the antimicrobial composition, or alternatively in an amount of 5 to 18% by weight, or alternatively in an amount of 5 to 17% by weight, or alternatively in an amount of 5 to 16% by weight, or alternatively in an amount of 5 to 15% by weight, or alternatively in an amount of 5 to 14% by weight, or alternatively in an amount of 5 to 13% by weight, or alternatively in an amount of 5 to 12% by weight, or alternatively in an amount of 5 to 11% by weight, or alternatively in an amount of 5 to 10% by weight, or alternatively in an amount of 5 to 9% by weight, or alternatively in an amount of 5 to 8% by weight, or alternatively in an amount of 5 to 7% by weight, or alternatively in an amount of 5 to 6% by weight.

[0091] In one embodiment, the at least one malodour neutralising system is present in the antimicrobial composition in an amount of 6-20% by weight, or alternatively in an amount of 7-20% by weight, or alternatively in an amount of 8-20% by weight, or alternatively in an amount of 9-20% by weight, or alternatively in an amount of 10-20% by weight, or alternatively in an amount of 11-20% by weight, or alternatively in an amount of 12-20% by weight, or alternatively in an amount of 13-20% by weight, or alternatively in an amount of 14-20% by weight, or alternatively in an amount of 15-20% by weight, or alternatively in an amount of 16-20% by weight, or alternatively in an amount of 17-20% by weight, or alternatively in an amount of 18-20% by weight, or alternatively in an amount of 19-20% by weight, relative to the antimicrobial composition.

[0092] In one embodiment, the at least one malodor neutralizing system is present in the malodor neutralizing composition at 5% by weight, or 6% by weight, or 7% by weight, or 8% by weight, or 9% by weight, or 10% by weight, or 11% by weight, or 12% by weight, or 13% by weight, or 14% by weight, or 15% by weight, or 16% by weight, or 17% by weight, or 18% by weight, or 19% by weight, or 20% by weight of the antimicrobial composition.

[0093] The present invention is illustrated by the following examples, but is not limited thereto.

[0094] Working Example Example 1: Determination of the antibacterial efficacy of fragrance materials in ethanolic solutions A. Preparation of bacterial suspension Bacterial suspensions of E. coli ATCC 10536 were prepared for antibacterial testing as follows: Stock cultures stored at -80°C were subcultured onto tryptic soy agar (TSA) plates and incubated at 37°C for 24 hours to obtain single colonies. Single colonies of the primary cultures were streaked onto TSA plates and incubated at 37°C for 24 hours to prepare secondary cultures. Single colonies of the secondary cultures were inoculated into 50 mL of tryptic soy broth (TSB) and incubated at 37°C for 18 hours at 180 rpm. Aliquots (0.5 ml) of the 18-hour cultures were inoculated into 50 ml of fresh TSB and incubated at 37°C for 2-3 hours at 180 rpm. When the broth reached an OD600 nm value of 1-2, the cells were harvested by centrifugation at 5,000 rpm for 10 minutes and then resuspended in the same fresh broth medium to obtain a target level of 1-5 × 10 8 Colony forming units (CFU) / mL were achieved and this suspension was used for further antibacterial testing.

[0095] b. Measurement of the bactericidal activity of fragrance ingredients in ethanol solution Unless otherwise specified, the log reduction test according to the present invention is measured according to the following method.

[0096] The Bacterial Contact Time (BCT) test based on the European standard EN-1276 was used to measure the dose-dependent bactericidal activity of fragrance ingredients in a 20% ethanol solution.

[0097] Various concentrations (doses) of the fragrance ingredients were prepared in 40% ethanol solution. Eleven replicates of each sample were added to a 96-well microtiter plate (120 μl per well) in one row, columns 1-11, with row B serving as the control sample for the ethanol solution. Then, 120 μl of the cell suspension (as prepared above) was added to approximately 1-5×10 8A concentration of 10000 CFU / ML was added to each well of the microtiter plate. A specific contact time (45 seconds) was allowed for the target bacterial strain. At the end of the contact time, serial dilutions were prepared in a 96-well plate with growth medium: 3 times 1:10 dilutions, then 17 times 1:2 dilutions. Each plate was sealed and incubated at 37°C under agitation (180 rpm). After incubation, the turbidity (OD 600 nm) of the wells was recorded by a Tecan microplate reader. Turbid cells were considered positive for viable cell growth. The total number of viable cells (log CFU / mL) was calculated for each sample. And the log reduction for each test composition at the final concentration (dose) was calculated against the control sample of 20% ethanol solution.

[0098] Example 2: Determination of the antibacterial effect of fragrance ingredients in different surfactant bases a. Preparation of test samples Test samples were prepared by mixing the perfume ingredients with the surfactant base and vigorously stirring for 24 hours. Samples with a clear appearance were selected for antibacterial testing.

[0099] b. Determining the antimicrobial efficacy of fragrance materials in surfactant systems The antibacterial efficacy was tested against Escherichia coli ATCC 10536, a representative Gram-negative bacterial strain, using the robotic bacterial contact time (BCT) test based on European Standard EN-1276 and EP Patent No. 2787827.

[0100] Preparation of screening and dilution plates: Aliquots (270 μl) of the compositions were distributed into wells of a 96-well microtiter plate (MTP) along two columns (B1-H1 and B7-H7) and 270 μl of MilliQ water was added to wells A1 and A7 as control samples. This MTP was labeled "screening plate." In another MTP labeled "dilution plate," 270 μl of Dey-Engley (D / E) neutralizing solution was added to columns 1 and 7. 270 μl of tryptone dilution solution was added to columns 2-6 and columns 8-12 of the dilution MTP by the liquid handling station of a Hamilton robot.

[0101] BCT Test & Neutralization & Dilution: Bacterial stock (30 μl) was then added to column 1 of the "Screening Plate" and mixed by the liquid handling station of the Hamilton robot. After 45 seconds of contact time, 30 μl of the mixture in column 1 was transferred to the corresponding wells of column 1 of the "Dilution Plate". After 5 minutes of neutralization in D / E neutralization solution, 30 μl of the neutralized mixture was transferred from column 1 to column 2 of the dilution MTP and mixed, then 30 μl of the mixture was transferred from column 2 to column 3. This process was repeated and the bacterial suspension was serially diluted across the plate up to column 6. Bacterial stock (30 μl) was then added to column 7 of the "Screening Plate" and mixed by the liquid handling station of the Hamilton robot. After 45 seconds of contact time, 30 μl of the mixture in column 7 was transferred to the corresponding wells of column 7 of the "Dilution Plate". After neutralization in D / E Neutralizing Solution for 5 minutes, 30 μl of the mixture was transferred from column 7 to column 8 of the dilution MTP and mixed, then an additional 30 μl of the mixture was transferred from column 8 to column 9. This process was repeated until the bacterial suspension was serially diluted across the plate up to column 12.

[0102] Plating: A volume of 30 μl from each well in the dilution MTP was transferred onto four tryptone soy agar (TSA) plates. The TSA plates were left undisturbed for approximately 2 hours to allow the 30 μl inoculation spots to dry, and then the plates were inverted and incubated overnight at 37° C. for 24 hours. After incubation, colonies were counted.

[0103] Log reduction calculation: Dilutions were selected by colony count, the viable cell count (CFU / mL) of the mixture in the "screening plate" was calculated, and the log reduction was calculated relative to the control MilliQ sample.

[0104] result Fragrance ingredients with high bactericidal activity in ethanol solution: when tested according to the test procedure described in Example 1, there is at least a 5.5 log reduction in bacterial viability against at least one gram-negative bacterium, preferably at least one of Escherichia coli, Salmonella sp., Pseudomonas aeruginosa, Pseudomonas fluorescens, Serratia marcescens and Klebsiella pneumoniae, with the bactericidal fragrance ingredient in an ethanol solution of 0.1% (w / v) or less.

[0105] Fragrance ingredients with high germicidal activity: 1-phenylethyl acetate, 1-octanol, (1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol, undecanal, (2E)-2-methyl-3-phenyl-2-propenal, (Z)-2-nonenal, 1-(5-propyl-1,3-benzodioxol-2-yl)ethenone, (2E,6Z)-2,6-nonadien-1-ol, ethyl benzoate, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, benzyl butyrate, 1-butoxycarbonylethyl butanoate, ethyl heptane. xanoate, 5-isopropyl-2-methylphenol, (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, methyl (2E)-2-methyl-2-hexenoate, ethyl (E)-3-phenyl-2-propenoate, methyl (E)-3-phenyl-2-propenoate, (Z)-3,7-dimethyl-2,6-octadienal, (E)-3,7-dimethyl-2,6-octadienal, 3,5,5-trimethyl-1-hexa ethanol, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, (2E)-2-ethyl-4-[2,2,3-trimethyl-3-cyclopenten-1-yl]-2-buten-1-ol, 4-decanolide, (Z)-4-decenal, 2-methoxy-4-propylphenol, 2,6-dimethyl-7-octen-4-one, 2,6-dimethyl-4-heptanol, (E)-3,7-dimethyl-2,6-octadien-1-ol, 2,4,6-trimethyl-3-cyclohexen-1-methanol, 2-methoxy-4-[(1E)-1-propanol, 1,2-Dimethoxy-4-[(1Z)-1-propen-1-yl]benzene, 1,2-Dimethoxy-4-[(1E)-1-propen-1-yl]benzene, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, (2,2-dimethyl-3-[(2Z)-3-methyl-2,4-pentadien-1-yl]oxirane, (2,2-dimethyl-3-[(2E)-3-methyl-2,4-Pentadien-1-yl]oxirane, 2-ethyl-1-hexanol, (Z)-3,7-dimethyl-2,6-octadien-1-ol, 1-(3-methyl-1-benzofuran-2-yl)ethenon, (Z)-6-nonen-1-ol, (2E,6Z)-2,6-nonadienal, 1,8-p-menthadien-7-ol, 3-methyl-5-phenyl-1-pentanol, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde, ethyl 2-hydroxybenzoate, 2-(5,5,6-trimethylbicyclo[2.2.1]heteroaryl)-2-methyl-1-phenylpropane, 1-methyl-1-phenylpropane, 1-methyl-2 ... 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 3-methylindole, 8-mercapto-3-p-menthanone, 3,7-dimethyl-3-octanol, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl Pyr-4-methylbicyclo[3.1.0]hexan-3-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one, thymol, 6-hexyltetrahydro-2H-pyran-2-one, 3-propylphenol, 2-cyclohexylethyl acetate, octanal, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, 5-heptyldihydro-2(3H)-furanone, 3-butylidene-1-benzo[c]furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-di Methyl-6-octenenitrile, Coriander Oil, Cyclopropyl Methyl (3Z)-3-Hexenoate, Cyclopropyl Methyl (3E)-3-Hexenoate, 3,7-Dimethyl-1-Octen-3-ol, Cinnamon Leaf Oil, 4-Decanolide, 3,5,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, 2,4,6-Trimethyl-3-Cyclohexene-1-Carboxaldehyde, Lavandin Sumiensis Essential Oil, Peppermint Oil, 3,6,7-Trimethyl-2,6-Octadienal, Petitgrain Paraguay Essential Oil, (2Z)-4,8-Dimethyl-2,7-nonadien-4-ol or combinations thereof.

[0106] [Table 1]

[0107] [Table 2]

[0108] [Table 3-1] [Table 3-2]

[0109] [Table 4]

[0110] Conclusion: In surfactant bases with low surfactant content (e.g., 2.5% surfactant as shown in Table 1), the perfume ingredients had high bactericidal activity. As the amount of surfactant in the base increased (e.g., 6% surfactant as shown in Table 2), the antibacterial activity of the perfume ingredients dramatically decreased. As shown in Tables 2 and 3, hydrotropes such as SCS or sodium salicylate could enhance the antibacterial activity of the perfume ingredients in the surfactant base. Unlike WO2006053458, the amount of hydrotrope in the present invention can be less than 4% to achieve high bactericidal activity in the surfactant base.

[0111] Example 3 In Vitro Efficacy of Compositions of the Invention in Surface Cleaning Products The antibacterial effect of the compositions of the present invention in a commercial surface cleaner sample, Pine-Sol® Multi-Surface Cleaner (Lemon Fresh), was measured. Briefly, the compositions of the present invention were added to Pine-Sol® Multi-Surface Cleaner to final concentrations of 0.25%, 0.5%, 0.75%, 1.0% and 1.25%. Aliquots (120 μL) of each sample were mixed with an equal volume of bacterial suspension of Escherichia coli (E. coli) ATCC 10536 as described above in wells of a 96-well plate (11 replicates). After a contact time of 3 minutes, the viable cells (log CFU) in each well were counted. The bactericidal effect was measured as a log reduction relative to a control sample of MilliQ water.

[0112] A high antibacterial effect was detected when the composition of the present invention was added to the base at 0.5 to 2%.

[0113] Example 4 In Vitro Efficacy of the Inventive Compositions Presented herein in Soap Bar Bases Table 5 shows the composition of the soap bar base. [Table 5]

[0114] A high antibacterial effect was detected when the composition of the present invention was added to the base at 0.5 to 2%.

[0115] Example 5 In Vitro Efficacy of the Inventive Compositions Presented herein in a Roll-On Deodorant Soap Base Table 6 shows the composition of the roll-on deodorant soap base. [Table 6]

[0116] A high antibacterial effect was detected when the composition of the present invention was added to the base at 0.5 to 1%.

Claims

1. a. a fragrance ingredient that has a germicidal effect of 5.5 log reduction in ethanol solution at a concentration of 0.1% or less; and b. Surfactants c. Hydrotropes 1. An antibacterial composition comprising:

2. 10. The antimicrobial composition of claim 1, wherein the fragrance component is at least 0.001% (w / v) of the antimicrobial composition.

3. 10. The antimicrobial composition of claim 1, wherein the surfactant is selected from the group consisting of anionic surfactants, nonionic surfactants, amphoteric surfactants, and combinations thereof.

4. 2. The antimicrobial composition of claim 1, wherein the anionic surfactant is sodium lauryl ether sulfate, the amphoteric surfactant is cocamidopropyl betaine, and the nonionic surfactant is coco-glucoside.

5. 10. The antimicrobial composition of claim 1, wherein the antimicrobial composition comprises less than 4% hydrotropes.

6. 6. The antimicrobial composition of claim 5, wherein the hydrotrope is selected from the group consisting of short chain alkyl polyglycosides, toluene sulfonates, xylene sulfonates, cumene sulfonates, diisobutyl sulfosuccinate, sodium salicylate, sodium acetate, and combinations thereof, or the hydrotrope is a sodium, ammonium, or potassium salt of a hydrotrope selected from the group consisting of toluene sulfonates, xylene sulfonates, cumene sulfonates, diisobutyl sulfosuccinate; dipropylene glycol n-butyl ether; and combinations thereof.

7. 10. The antimicrobial composition of claim 1, wherein the antimicrobial composition further comprises an additional agent having activity against gram-positive or gram-negative bacteria.

8. 10. The antimicrobial composition of claim 1, wherein the antimicrobial composition further comprises a chelating agent selected from the group consisting of EDTA and CDTA, and combinations thereof.

9. The fragrance ingredients include 1-phenylethyl acetate, 1-octanol, (1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol, undecanal, (2E)-2-methyl-3-phenyl-2-propenal, (Z)-2-nonenal, 1-(5-propyl-1,3-benzodioxol-2-yl)ethenone, (2E,6Z)-2,6-nonadien-1-ol, ethyl benzoate, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, benzyl butyrate, 1-butoxycarbonylethyl butanoate, ethyl hexanoate phenol, 5-isopropyl-2-methylphenol, (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, methyl (2E)-2-methyl-2-hexenoate, ethyl (E)-3-phenyl-2-propenoate, methyl (E)-3-phenyl-2-propenoate, (Z)-3,7-dimethyl-2,6-octadienal, (E)-3,7-dimethyl-2,6-octadienal, 3,5,5-trimethyl-1-hexanol , 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, (2E)-2-ethyl-4-[2,2,3-trimethyl-3-cyclopenten-1-yl]-2-buten-1-ol, 4-decanolide, (Z)-4-decenal, 2-methoxy-4-propylphenol, 2,6-dimethyl-7-octen-4-one, 2,6-dimethyl-4-heptanol, (E)-3,7-dimethyl-2,6-octadien-1-ol, 2,4,6-trimethyl-3-cyclohexene-1-methanol, 2-methoxy-4-[(1E)-1-propene -1-yl]phenol, (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol, 2,5-dimethyl-2-indanemethanol, 1,2-dimethoxy-4-[(1Z)-1-propen-1-yl]benzene, 1,2-dimethoxy-4-[(1E)-1-propen-1-yl]benzene, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, (2,2-dimethyl-3-[(2Z)-3-methyl-2,4-pentadien-1-yl]oxirane, (2,2-dimethyl-3-[(2E)-3-methyl-2,4-pentadien-1-yl]oxirane, 2-ethyl-1-hexanol, (Z)-3,7-dimethyl-2,6-octadien-1-ol, 1-(3-methyl-1-benzofuran-2-yl)ethenone, (Z)-6-nonen-1-ol, (2E,6Z)-2,6-nonadienal, 1,8-p-menthadien-7-ol, 3-methyl-5-phenyl-1-pentanol, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde, ethyl 2-hydroxybenzoate, 2-(5,5,6-trimethylbicyclo[2.2.1]he 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 3-methylindole, 8-mercapto-3-p-menthanone, 3,7-dimethyl-3-octanol, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl Pyri-4-methylbicyclo[3.1.0]hexan-3-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one, thymol, 6-hexyltetrahydro-2H-pyran-2-one, 3-propylphenol, 2-cyclohexylethyl acetate, octanal, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, 5-heptyldihydro-2(3H)-furanone, 3-butylidene-1-benzo[C]furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-di Methyl-6-octenenitrile, Coriander Oil, Cyclopropylmethyl (3Z)-3-hexenoate, Cyclopropylmethyl (3E)-3-hexenoate, 3,7-dimethyl-1-octen-3-ol, Cinnamon Leaf Oil, 4-Decanolide, 3,5,6-Trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-Trimethyl-3-cyclohexene-1-carbaldehyde, Lavandin Sumiang Essential Oil, Peppermint Oil, 3,6,7-Trimethyl-2,6-octadienal, Petitgrain Paraguay Essential Oil, (2Z)-4,8-Dimethyl-2,The antibacterial composition of claim 1, wherein the antibacterial agent is selected from the group consisting of 7-nonadiene-4-ol, 7-nonadien-4-ol, or a combination thereof.

10. The fragrance component is (4E,8E)-4,8-cyclododecadien-1-one, (4E,8Z)-4,8-cyclododecadien-1-one, (4Z,8E)-4,8-cyclododecadien-1-one, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-6-octen-1-ol, (2Z), -4,8-dimethyl-2,7-nonadien-4-ol, 1,3-nonanediyl diacetate, tetrahydro-3-pentyl-4(2H)-pyranyl acetate, (Z)-4-decenal, 3-[4-methyl-3-cyclohexen-1-yl]-1-butanol, undecanal, (2E)-2-ethyl-4-[2,2,3-trimethyl-3-cyclopenten-1-yl]-2- 2. The antimicrobial composition of claim 1, wherein the antimicrobial agent is selected from the group consisting of buten-1-ol, 3,7-dimethyl-3-octanol, 2-(5,5,6-trimethylbicyclo[2.1.1]hept-2-yl)-1-cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-cyclohexylethyl acetate, 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one, 1-isopropyl-4-methylbicyclo[3.1.0]hexan-3-one, or a combination thereof.

11. 2. The antimicrobial composition of claim 1, wherein the fragrance ingredient is selected from the group consisting of cyclopropylmethyl (3Z)-3-hexenoate or cyclopropylmethyl (3E)-3-hexenoate, 3,6,7-trimethyl-2,6-octadienal, (2Z)-4,8-dimethyl-2,7-nonadien-4-ol, octanal, 5-heptyldihydro-2(3H)-furanone, 3,7-dimethyl-6-octen-1-ol, 3,7-dimethyl-6-octenenitrile, 3,7-dimethyl-1-octen-3-ol, cinnamon leaf oil, lavandinium sumiensis essential oil, 2-cyclohexylethyl acetate, peppermint oil, coriander oil, petitgrain Paraguay essential oil, 3-butylidene-1-benzo[C]furanone, or a combination thereof.

12. The antimicrobial composition of claim 1 further comprising a solvent and / or a water-miscible co-solvent.

13. 10. The antimicrobial composition of claim 1, further comprising ingredients such as colorants, preservatives, viscosity agents, opacifiers, emollients, humectants, antioxidants, gelling agents, gums, chelating agents, functional polymers, cellulose derivatives, essential oils, electrolytes, and pH adjusters.

14. 10. The antimicrobial composition of claim 1, further comprising a malodor neutralizing system and / or a malodor antagonist system.

15. 15. A consumer product comprising the antimicrobial composition of any one of claims 1 to 14, the consumer product being selected from the group consisting of a hair care product, a body care product, a skin care product, an oral care product, a feminine care product, a home care product, a laundry care product, or a body cleansing product, such as, but not limited to, a shampoo, a shower gel, a facial cleanser, a shaving gel, a liquid hand soap, a foam soap, a hand sanitizer, a soap bar, a mouthwash, a dentifrice, a feminine hygiene composition, a fabric cleanser, a carpet cleanser, an all-purpose cleanser, a dishwashing detergent, a fresh goods detergent, a deodorizer, an air freshener, and an air sanitizer.

16. 15. A method of eliminating and / or reducing the number of microorganisms on a surface or body part, comprising contacting the surface or body part with an antimicrobial composition according to any one of claims 1 to 14.