Cosmetic Composition Comprising Cranberry Extract and Cranberry Seed Oil - Patent application

Abstract

The present invention provides a cosmetic composition for topical use comprising cranberry extract in combination with cranberry seed oil.

Description

[Technical field]

[0001] The present invention relates to a cosmetic composition for topical use comprising a combination of cranberry extract and cranberry seed oil. In particular, the present invention relates to a cosmetic composition for topical use comprising a combination of cranberry extract and cranberry seed oil, the ratio of cranberry extract to cranberry seed oil being between about 15:1 and about 1:0.5. The present invention also relates to a cosmetic product comprising a cosmetic composition comprising cranberry extract in combination with cranberry seed oil as defined herein, as well as a method for alleviating symptoms of inflammation of human skin or human scalp, comprising topically applying to the skin or scalp a cosmetic composition or cosmetic product as defined herein. The present invention also relates to the use of a cosmetic composition or cosmetic product as defined herein in alleviating symptoms of inflammation of human skin or human scalp. [Background technology]

[0002] background Cranberries (Vaccinium macrocarpon) contain large amounts of antioxidants, vitamins, minerals, and phenolic compounds, which have prompted their increasing use in a variety of food products and dietary supplements. Extracts from cranberries are also used in many cosmetic products for their anti-glycation, antibacterial, antioxidant, and anti-aging properties. The seeds separated from the fruit are the source of cranberry seed oil. Cranberry seed oil offers a unique combination of omega-3, omega-6, and omega-9 fatty acids as well as tocopherols, tocotrienols, and high concentrations of antioxidants. The oil is used in many cosmetic products for its moisturizing, nourishing, anti-aging, antioxidant, antibacterial, UV-protective, anti-irritant, and whitening properties.

[0003] Skin inflammation has a co-dependent relationship with oxidative stress and can manifest in various ways such as redness, breakouts, acne, age spots, rosacea, dark spots, hyperpigmentation, eczema, itching, or swelling. Scalp inflammation, although difficult to identify, can be observed as scalp flaking, swelling, or redness. Commercially available soothing compositions are available to reduce the unpleasant sensation and appearance of skin and scalp inflammation.Of these compositions, those that contain natural extracts have become more popular in recent years.Most natural soothing compositions contain extracts from, for example, arnica, aloe vera, calendula, chamomile (containing bisabolol), coconut oil, green tea, oatmeal, shea butter, and tea tree oil. Although not as widely used as the ingredients mentioned above, cranberry extract has also been shown to have skin and scalp soothing properties, with high concentrations of cranberry polyphenols believed to be responsible for such effects. There remains a need to provide compositions containing natural and / or upcycled ingredients, particularly compositions based on cranberry elements, that have a soothing effect on human skin or scalp (i.e., that can reduce or alleviate symptoms of skin or scalp inflammation). Summary of the Invention

[0004] Summary of the Invention In a first aspect, the present invention provides a cosmetic composition for topical use comprising a cranberry extract in combination with cranberry seed oil. In a further aspect, there is provided a cosmetic product comprising a cosmetic composition for topical use comprising a cranberry extract in combination with cranberry seed oil as defined herein, and a cosmetically acceptable base. The present invention further provides a method, in particular a cosmetic method, for alleviating or eliminating symptoms of inflammation of human skin or the human scalp comprising applying to the skin or scalp a cosmetic composition or cosmetic product as defined herein. In another aspect, there is provided use of a cosmetic composition or cosmetic product as defined herein in alleviating or relieving symptoms of inflammation of human skin or the human scalp. [Brief description of the drawings]

[0005] BRIEF DESCRIPTION OF THE DRAWINGS [Figure 1] FIG. 1 shows a nonparametric statistical analysis using a Mann-Whitney test of TNF-α quantification in samples of cultured cells treated with cranberry extract, cranberry seed oil, and a combination of cranberry extract and cranberry seed oil compared to samples treated with the reference (dexamethasone). DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0006] Detailed explanation Preferred and / or optional features of the invention are now described. Any aspect of the invention may be combined with any other aspect of the invention unless the context requires otherwise. Any preferred or optional feature of any aspect may be combined with any aspect of the invention, as well as with any other preferred or optional feature, either alone or in combination, unless the context requires otherwise.

[0007] Cosmetic Composition Surprisingly, it was discovered that the combination of cranberry extract and cranberry seed oil exhibited synergistic anti-inflammatory activity by significantly reducing the release of the cytokine TNF-α by phorbol 12-myristate 13-acetate (PMA)-stressed keratinocytes. Notably, it was discovered that when the combination of cranberry extract and cranberry seed oil was used, not only was the TNF-α release significantly reduced compared to when either cranberry extract or cranberry seed oil was used alone, but that the TNF-α release was much lower than would be expected from the additive effects of the two components alone.

[0008] Thus, the present invention provides a cosmetic composition for topical use comprising a combination of cranberry extract and cranberry seed oil. Cranberries, from which both the cranberry extract and the cranberry seed oil are obtained, may be sourced, for example, from the United States.

[0009] Cranberry Extract The cranberry extract is obtained from the berries of Vaccinium macrocarpon, preferably from the juice obtained by squeezing them. For example, cranberry extract can be obtained by a process of extraction from cranberry fruit. After harvesting, drying and crushing, cranberries can be contacted with a solvent that has an affinity for the desired components to be extracted. A filtration step can then be performed to separate the solvent in which the desired components are dissolved from the solid matrix of the cranberry to provide a native extract. The solvent can then be removed, for example evaporated, to concentrate the filtrate. The resulting native extract can be further processed by separation, purification, and / or further formulation. Suitable extraction methods include ultrasonic extraction, microwave-assisted extraction, or Soxhlet extraction. The solvents used in the extraction process can be hydrophilic or lipophilic. Depending on the solvent used, the cranberry extract may be referred to as a "hydrophilic extract" or a "lipophilic extract."

[0010] In one embodiment, the cranberry extract is a hydrophilic extract. Examples of suitable hydrophilic solvents that may be used in the extraction process include, but are not limited to, water; alcohols such as methanol, ethanol, propanol (normal or iso), butanol (normal, iso, or tert); ketones such as acetone; nitriles such as acetonitrile; or mixtures thereof. Optionally, acids such as hydrochloric acid or sulfuric acid, or organic acids such as trichloroacetic acid, trifluoroacetic acid, formic acid, citric acid, or acetic acid, or mixtures thereof may be used to facilitate the extraction. In one embodiment, the cranberry extract is an upcycled product obtained after partial extraction of polyphenols from cranberry juice.

[0011] In one embodiment, the cranberry extract contains organic acids such as phenolic acids, particularly those derived from hydroxybenzoic and hydroxycinnamic acids, quinic acid, malic acid, shikimic acid, and citric acid. In one embodiment, the solvent used to extract the desired components may be a water-ethanol mixture.

[0012] In one embodiment, the cranberry extract may contain between about 7% and about 30% w / w organic acids. Illustratively, the cranberry extract may contain about 7%, about 18%, or about 30% organic acids by weight of the extract. It has been shown that polyphenol plant sources possess antioxidant activity and can potentially prevent and control oxidative stress and its effects (Silva Caldas, AP, International Journal of Food Properties, 2018, 21, 582-592, the disclosure of which is incorporated herein by reference). Therefore, it is advantageous to use a cranberry extract with a high content of organic acids, such as phenolic acids.

[0013] Thus, in one embodiment, the cranberry extract contains greater than about 30% organic acids by weight of the extract. Optionally, the cranberry extract may be further mixed with additives. Additives are substances added to a natural extract to maintain or improve its stability, texture, or appearance. For example, the additive may be selected from the group consisting of sodium benzoate, potassium sorbate, magnesium hydroxide, tricalcium phosphate, glycerin, and mixtures thereof, whose role is to stabilize the pH of the cranberry extract.

[0014] In one embodiment, the additive may be magnesium hydroxide. Optionally, the cranberry extract may contain further additives such as tricalcium phosphate. In one embodiment, the cranberry extract may contain about 10% w / w magnesium hydroxide. In one embodiment, the cranberry extract may contain less than about 1% w / w tricalcium phosphate. In one embodiment, the cranberry extract may contain about 10% w / w magnesium hydroxide, and less than about 1% w / w tricalcium phosphate. The cranberry extract may be in any suitable form, such as liquid or powder form.

[0015] In one embodiment, the cranberry extract may undergo further processing, such as drying. Optionally, additives may be added to the cranberry extract prior to the drying step. For example, cranberry extract may be obtained by the process as described herein. Cranberry fruit may be crushed and extracted with a mixture of water and ethanol, and then filtered. The filter cake may be discarded, and the solvent may be removed from the filtrate, for example by concentration, to obtain a native extract of cranberry. The native extract may be further processed by removing a polyphenol-rich fraction. The fraction remaining after removing the polyphenol-rich fraction may be mixed with magnesium hydroxide and / or tricalcium phosphate, and the mixture may be dried, for example by spray drying, and may optionally be further sieved.

[0016] Cranberry Seed Oil Cranberry seed oil possesses omega-3 fatty acids (approximately 26%-34% w / w), omega-6 (approximately 32%-42% w / w), and omega-9 (approximately 18%-30% w / w), as well as tocopherols, tocotrienols, and antioxidants. A number of extraction techniques may be used to extract cranberry seed oil, such as solvent extraction, ultrasonic extraction, supercritical fluid extraction, Soxhlet extraction, or mechanical expression.

[0017] Since some compounds found in cranberry seed oil may be destroyed or removed during steam stripping or solvent extraction processes, preferably the cranberry seed oil is obtained by cold pressing, resulting in virgin (i.e., oil produced by physical or mechanical means only) cranberry seed oil. Thus, in one embodiment, the cranberry seed oil may be virgin cranberry seed oil. For example, cranberry seed oil may be obtained by the process as described herein. The seeds removed from the fruit may be cold pressed and filtered. The filter cake may be discarded and the filtrate (i.e., virgin cranberry seed oil) may be used as is.

[0018] Cranberry Extract and Cranberry Seed Oil As mentioned above, both cranberry extract and cranberry seed oil have been used in cosmetic products due to their beneficial properties when applied to the skin. However, no studies have been conducted to date to evaluate the anti-inflammatory effects of cranberry extract or cranberry seed oil. Surprisingly and unexpectedly, it was observed that the combination of cranberry extract and cranberry seed oil significantly reduces the release of cytokine TNF-α in phorbol 12-myristate 13-acetate (PMA)-stressed keratinocytes compared to the treatment with cranberry extract or cranberry seed oil alone.The effect of the combination of cranberry extract and cranberry seed oil on the release of cytokine TNF-α is much higher than that expected by simply adding the effects of two independent components.In this way, the synergistic effect of the combination of cranberry extract and cranberry seed oil can be clearly observed (see, for example, Example 3 below).

[0019] In one embodiment, the ratio between the cranberry extract and the cranberry seed oil is between about 15:1 and about 1:0.2. Preferably, the ratio between the cranberry extract and the cranberry seed oil is between about 12:1 and about 1:0.5. For example, the ratio between the cranberry extract and the cranberry seed oil may be about 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:0.9, 1:0.8, 1:0.7, 1:0.6, or 1:0.5, particularly about 10:1 or about 1:1.

[0020] Cosmetic products Another aspect of the present invention provides a cosmetic product comprising a cosmetic composition comprising a cranberry extract in combination with cranberry seed oil as defined in the preceding paragraph, and a cosmetic base. The cosmetic base may include any cosmetically acceptable excipient. The cosmetically acceptable excipient may be any excipient commonly used in the preparation of cosmetic preparations for use on human skin or scalp. Suitable excipients include, but are not limited to, ingredients that can affect the sensory properties and permeability of the skin, as well as the amount of time that the active ingredient(s) remain active on the skin. More specifically, they include liquids such as water, oils, or surfactants, which are of petroleum, animal, vegetable, or synthetic origin, such as, but not limited to, peanut oil, soybean oil, mineral oil, sesame oil, castor oil, polysorbates, sorbitan esters, ether sulfates, sulfates, betaines, glycosides, maltosides, fatty alcohols, nonoquinol, poloxamers, polyoxyethylene, polyethylene glycols, dextrose, glycerol, digitonin, and the like, or combinations thereof.

[0021] The formulation for topical application to the skin may take any physical form. Illustratively, the cosmetic product may be in the form of liposomes, mixed liposomes, oleosomes, niosomes, ethosomes, milliparticles, microparticles, nanoparticles and solid-lipid nanoparticles, vesicles, micelles, surfactant mixed micelles, surfactant-phospholipid mixed micelles, millispheres, microspheres and nanospheres, lipospheres, millicapsules, microcapsules and nanocapsules, as well as microemulsions and nanoemulsions, which may be added to achieve a higher penetration of the cosmetic composition as defined herein.

[0022] Cosmetic products may be produced in any solid, liquid, or semi-solid form that is useful for topical or transdermal application. Thus, these preparations for topical or transdermal application include, but are not limited to, creams, numerous emulsions, including, but not limited to, oil-in-water and / or silicone emulsions, water-in-oil and / or silicone emulsions, water / oil / water or water / silicone / water emulsions, and oil / water / oil or silicone / water / silicone emulsions, micro-emulsions, emulsions and / or solutions, liquid crystals, anhydrous compositions, aqueous dispersions, oils, milks, balsams, foams, aqueous or oily lotions, aqueous or oily gels, creams, hydro-alcoholic solutions, hydro-glycolic solutions, hydrogels, liniments, sera, soaps, face masks, serums, polysaccharide films, ointments, mousses, pomades, pastes, powders, bars, pencils, and sprays or aerosols (sprays), including leave-on and rinse-off formulations.

[0023] The cosmetic product of the present invention may also be any product typically used in hair care, including but not limited to shampoo, conditioner, spray, treatment, mask, strengthener, pre-shampoo, lotion, serum, cream, foam, mousse, and gel.More preferably, the cosmetic product is shampoo, anti-frizz hairspray, beauty hair mask, shine serum, hair conditioner, hair strengthening pre-shampoo, or hair protection lotion.Both leave-on and rinse-off product types are suitable.

[0024] Cosmetic products according to the present invention may further comprise one or more materials selected from the group consisting of carriers, solvents, surfactants, thickeners, styling polymers, anti-dandruff actives, antimicrobial materials, skin and scalp actives, vitamins, salts, buffers, hair growth agents, conditioning materials, hair fixative polymers, fragrances, colorants / colorants, dyes, pigments, opacifiers, pearlescent aids, oils, waxes, preservatives, sensates, sunscreens, drugs, antifoaming agents, antioxidants, binders, biological additives, buffers, extenders, chelating agents, chemical additives, film formers or materials, pH adjusters, propellants, oxidizing agents, and reducing agents.

[0025] The cosmetic products of the present invention may be produced in any form typically used in the care of the skin or scalp, including, but not limited to, a cream, lotion, spray, gel, foam, stick, shampoo, conditioner, or mousse, and are preferably a cream or gel. The cosmetic composition and product of the present invention may further include any suitable optional ingredient as necessary. Such optional ingredients should be physically and chemically compatible with the essential ingredients of the cosmetic composition or cosmetic product, and should not otherwise unduly impair stability, aesthetics, or performance. The CTFA Cosmetic Ingredient Handbook, Tenth Edition (published by the Cosmetic, Toiletry, and Fragrance Association, Inc, Washington DC) (2004) describes a wide variety of non-limiting materials that can be added to the composition and product of the present invention.

[0026] The concentration of cranberry extract in a topical formulation of the cosmetic composition can be up to about 30% w / w. In one embodiment, the cosmetic product comprises from about 0.5% to about 30%, optionally from about 1% to about 25%, optionally from about 5% to about 15% w / w of cranberry extract. In one embodiment, the cranberry extract may be provided in powder form and mixed with a solvent such as water, ethanol / water, or glycerin prior to incorporation into the cosmetic product. The concentration of cranberry seed oil in a topical formulation of a cosmetic product can be up to about 10% w / w. In one embodiment, the cosmetic product comprises from about 0.05% to about 10%, optionally from about 0.5% to about 5%, optionally from about 1% to about 3% w / w cranberry seed oil.

[0027] How to use The present invention further provides a method for alleviating or eliminating symptoms of inflammation on human skin or on the human scalp comprising topically applying to the skin or scalp a cosmetic product comprising a composition comprising a cranberry extract in combination with cranberry seed oil, or a composition comprising a cranberry extract in combination with cranberry seed oil as defined in the preceding paragraph. In particular, the present invention provides a cosmetic, i.e. non-therapeutic, method for alleviating or eliminating the symptoms of inflammation of human skin or the human scalp. In one embodiment, inflammation of the human skin or the human scalp may be caused by an infection, by an allergic reaction, or by exposure to ultraviolet light.

[0028] In one embodiment, the human skin inflammation may be selected from the group consisting of sensitive skin, inflammatory skin, atopic dermatitis, rosacea, eczema, and psoriasis. In one embodiment, the inflammation of the human scalp may be selected from the group consisting of dry inflamed skin, itchy scalp, dermatitis such as seborrheic dermatitis and contact dermatitis, folliculitis of the scalp, and psoriasis of the scalp. Non-limiting examples of symptoms of inflammation include redness, pimples, acne, age spots, rosacea, dark spots, hyperpigmentation, eczema, itching, or swelling of the skin, and flaky, swollen, or red scalp.

[0029] In another aspect, there is provided use of a composition comprising a cranberry extract in combination with cranberry seed oil, or a cosmetic product comprising a composition comprising a cranberry extract in combination with cranberry seed oil as defined in the preceding paragraph, in alleviating or eliminating symptoms of inflammation of human skin or the human scalp. In particular, the present invention provides a cosmetic use, i.e. a non-therapeutic use, for alleviating or eliminating the symptoms of inflammation of human skin or the human scalp. EXAMPLES

[0030] The invention will now be further described by way of the following non-limiting examples: Example 1: Cranberry Extract Production Process Cranberry fruit may be crushed and extracted with a mixture of water and ethanol, and filtered. The filter cake may be discarded, and the filtrate may undergo concentration / desolventization to obtain a native extract of cranberry. The resulting native extract may be further subjected to separation, purification, and further formulation by mixing with magnesium hydroxide and tricalcium phosphate. The mixture may be dried by spray drying, and may optionally undergo further sieving. For example, 134 kg of cranberries were crushed and extracted with 80 kg of water. The liquid was separated from the solid mass, concentrated, and subjected to further processing, including mixing with magnesium hydroxide (8 kg) and tricalcium phosphate (1 kg). 92 kg of cranberry extract was obtained, along with 30% w / w organic acids.

[0031] Example 2: Cranberry Seed Oil Production Process The seeds removed from the fruit may also be cold pressed and filtered. The filter cake may be discarded and the filtrate (i.e., virgin cranberry seed oil) may be used as is. For example, 1.667 kg of cranberries were squeezed, sliced, and the seeds removed. The seeds (approximately 17 g) were collected, dried, and cold pressed to yield approximately 1 g of cranberry seed oil.

[0032] Example 3: Anti-inflammatory effects of cranberry extract, cranberry seed oil, and the combination of cranberry extract and cranberry seed oil The effects of cranberry extract, cranberry seed oil, and a combination of cranberry extract and cranberry seed oil on the anti-inflammatory activity of PMA-stressed keratinocytes were evaluated by comparing the reduction in cytokine TNF-α release from PMA (phorbol 12-myristate 13-acetate)-stressed normal human epidermal keratinocytes (NHEK) treated with cranberry products with the TNF-α release from untreated PMA-stressed NHEK.

[0033] 3.1 Cell culture and treatments Cell culture was performed with primary cells isolated from fresh biopsies. NHEKs were seeded at 30,000 cells per well in triplicate on 24-well plates precoated with type I collagen. Cells were incubated in complete medium (EpiLife medium supplemented with HKGS, Gibco) and 1% antibiotics (Sigma-Aldrich) for 24 hours at 37° C., 5% CO 2 .

[0034] At the end of the incubation, the cells were washed twice with phosphate-buffered saline (PBS, Gibco) and preincubated with the active factors for 24 h at 37°C and 5% CO2 in EpiLife complete medium (EpiLife + Human Keratinocyte Growth Supplement (HKGS) Supplement, Gibco) minus hydrocortisone and 1% antibiotics. After 24 h preincubation, cells were stressed with 1 ng / mL of PMA (phorbol 12-myristate 13-acetate, Sigma) and incubated at 37° C., 5% CO 2 for 24 h. The compounds used for comparison are shown in Table 1. Untreated cells were used as a blank. Cells treated with a known anti-inflammatory agent (dexamethasone) were used as a reference.

[0035] Table 1: Compounds and cranberry products tested for anti-inflammatory effects on NHEK [Table 1] Untreated skin cells cultured with medium were used as a negative control. At the end of the incubation, the cell culture medium was collected and centrifuged at 2000 g for 10 min at 4° C. to remove dead cells. The medium was stored at −20° C. To assess treatment toxicity, an MTT assay was performed for standardization of TNF-α quantification. Assays were performed in quadruplicate.

[0036] 3.2 MTT assay MTT solution (Sigma) diluted at 1 mg / mL in basal medium was added to each well and incubated at 37°C and 5% CO2 for 3 hours. Afterwards, the medium was removed and 300 μL of dimethyl sulfoxide (DMSO, Sigma) was added to each well to dissolve the formazan crystals. Homogenization was performed for several minutes under orbital stirring. Optical density was measured at a wavelength of 560 nm.

[0037] 3.3 Quantification of TNF-α Quantification of TNF-α was performed using the Human TNF-alpha Quantikine ELISA kit (DTA00D, R&D Systems). Samples and standard ranges were incubated in the presence of Assay Diluent RD1F for 2 hours in a 96-well plate precoated with a monoclonal antibody specific for human TNF-α. After 4 washes with the wash buffer provided by the supplier, a polyclonal antibody specific for human TNF-α conjugated with horseradish peroxidase enzyme (HRP) was incubated for 2 hours under orbital agitation. Following 4 washes, a substrate solution was added to the wells for 30 minutes in the dark. Catalysis of this substrate by HRP produces a blue color proportional to the amount of TNF-α bound in the first step. The color development was stopped by a stop solution, which turned yellow. The optical density was measured at 450 nm and 540 nm using a microplate reader (TECAN SPARK® 10M).

[0038] After subtracting the optical density at 450 nm with the optical density at 540 nm, a four-parameter logistic curve analysis was performed via the Myassays website (http: / / myassays.com). Quantification was performed in duplicate. Quantification was normalized to optical density measured via MTT assay.

[0039] 3.4 Statistical analysis The Shapiro-Wilk normality test revealed that the samples did not follow the Gaussian law. As a result, non-parametric statistical analysis was performed using Kruskal-Wallis ANOVA followed by the Mann-Whitney U test. Results were considered significant at p<0.1 (marked with #), p<0.05 (marked with *), p<0.01 (marked with **), and p<0.001 (marked with ***).

[0040] FIG. 1 shows the results of non-parametric statistical analysis of Samples 1 to 7 in Table 1 using the Mann-Whitney test. Quantification demonstrated that 24 hours after PMA stress (item 1 in Table 1), keratinocytes significantly released the cytokine TNF-α. Pretreatment with dexamethasone (1 μM, item 2) significantly reduced cytokine release by 46%***. These results confirmed the responsiveness of the model.

[0041] Under the same conditions, cranberry extract at 0.5 mg / mL (item 3), cranberry seed oil at 0.05% v / v (item 4), and cranberry seed oil at 0.005% v / v (item 5) significantly reduced TNF-α release by 16%*, 34%***, and 32%***, respectively, compared to the sample in item 1. In the presence of a combination of cranberry extract at 0.5 mg / mL and cranberry seed oil at 0.05% v / v (i.e., a 1:1 ratio, item 4), the reduction in TNF-α release was significantly higher (75%***). The reduction was significantly greater than that predicted by adding up the reductions from each component individually.

[0042] In the presence of a combination of cranberry extract at 0.5 mg / mL and cranberry seed oil at 0.005% v / v (i.e., a 10:1 ratio, item 6), there was a significant (p<0.001) reduction in TNF-α release of 61%***, which was greater than would be expected by simply adding up the reductions from each component individually. Thus, the combination of cranberry extract and cranberry seed oil has been shown to have synergistic anti-inflammatory performance compared to each of cranberry extract and cranberry seed oil alone.

Claims

1. A cosmetic composition for topical use comprising a cranberry extract in combination with cranberry seed oil.

2. 10. The cosmetic composition of claim 1, wherein the cranberry extract is a hydrophilic extract.

3. 10. The cosmetic composition of claim 1, wherein the cranberry extract contains greater than about 30% w / w organic acids.

4. 10. The cosmetic composition of claim 1, wherein the cranberry extract further comprises an additive.

5. The cosmetic composition of claim 4 , wherein the additive comprises magnesium hydroxide and / or tricalcium phosphate.

6. 6. The cosmetic composition of claim 5, comprising about 5% to about 10% w / w magnesium hydroxide and / or less than about 1% w / w tricalcium phosphate.

7. 2. The cosmetic composition of claim 1, wherein the cranberry seed oil is virgin cranberry seed oil.

8. 10. The cosmetic composition of claim 1, wherein the cranberry extract and cranberry seed oil are in a ratio of between about 15:1 and about 1:0.

5.

9. A cosmetic product comprising the cosmetic composition according to any one of claims 1 to 8 and a cosmetically acceptable base material.

10. 10. The cosmetic product of claim 9, wherein the product is provided as a cream, lotion, spray, gel, foam, stick, shampoo, conditioner, or mousse.

11. 10. The cosmetic product of claim 9, wherein the cosmetic product comprises from about 0.5% to about 30% w / w, preferably from about 1% to about 25% w / w, and most preferably from about 5% to about 15% w / w of cranberry extract, and from about 0.05% to about 10% w / w, preferably from about 0.5% to about 5% w / w, and most preferably from about 1% to about 3% w / w of cranberry seed oil.

12. A method for alleviating or eliminating the symptoms of inflammation of human skin or human scalp, comprising topically applying to the skin or scalp a cosmetic composition according to any one of claims 1 to 8. The method.

13. 13. The method of claim 12, wherein the inflammation of the human skin or the human scalp is caused by an infection, by an allergic reaction, or by exposure to ultraviolet light.

14. 13. The method of claim 12, wherein the inflammation of human skin is selected from the group consisting of sensitive skin, inflammatory skin, atopic dermatitis, rosacea, eczema, and psoriasis.

15. 13. The method of claim 12, wherein the inflammation of the human scalp is selected from the group consisting of dry inflamed skin, itchy scalp, dermatitis such as seborrheic dermatitis and contact dermatitis, folliculitis of the scalp, and psoriasis of the scalp.

16. Use of a cosmetic composition according to any one of claims 1 to 8 in alleviating or eliminating the symptoms of inflammation of human skin or the human scalp.

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