Skin Care Composition

Abstract

Disclosed is a skin care composition that provides anti-inflammatory benefits. The composition comprises coffee seed oil and a hydroxy-substituted C8-C 24 fatty acid, which is 12-hydroxystearic acid, in which coffee seed oil and hydroxy-substituted C8-C 24 The weight ratio of the fatty acids is 1:5 to 15:1.

Description

[Technical field]

[0001] The present invention relates to skin care compositions. In particular, the present invention relates to skin care compositions for providing enhanced anti-inflammatory benefits. [Background technology]

[0002] Inflammation is a complex biological host response to harmful stimuli such as pathogens, irritants or injury. The immune response in the skin is important for the host's defense against pathogenic agents. However, a dysregulated immune response can cause several inflammatory skin conditions.

[0003] Although some consumers desire beautiful skin, in real life, they often encounter various skin problems caused by inflammation, such as acne, post-inflammatory hyperpigmentation (PIH), and aging. Acne, also known as acne vulgaris, is a common inflammatory problem of the skin that affects the pilosebaceous unit of the skin. Acne can leave severe scars on the skin of a subject and can have a severe psychological impact.

[0004] PIH is a skin pigmentation that occurs during or after an inflammatory process. PIH can be observed in any skin type and at any age. In most cases, PIH has a significant impact on the quality of life of the affected individual. External stimuli such as UV exposure can also cause inflammation, which can accelerate skin aging leading to further signs of photoaging.

[0005] To address the problems associated with inflammation, several approaches have been taken, such as local and systemic treatments using antibiotics or steroids. However, these treatments can be irritating or have other side effects. For example, antibiotics can lead to antibiotic resistance. Summary of the Invention [Problem to be solved by the invention]

[0006] Therefore, there remains a need to develop new solutions with regard to anti-inflammatory benefits. [Means for solving the problem]

[0007] Coffee is one of the most consumed beverages on earth. Coffee beans are the seeds of certain Coffea species fruits, which are usually roasted to make a cup of coffee. Coffee seed oil is an oil extracted from unroasted or roasted coffee seeds. Coffee seed oil can be extracted from unroasted or roasted coffee seeds by cold press distillation. Coffee seed oil is an ingredient that is sometimes used in skin care products.

[0008] Koffee'UP, roasted arabica seed oil TM is a Givaudan product made from dried used coffee grounds followed by supercritical CO2 extraction. According to Givaudan, the balance between saturated and unsaturated fatty acids helps the oil penetrate the skin layers quickly.

[0009] Cosmetics containing coffee seed oil are known on the market, for example the Clinique Smart Clinical MD collection is a skin care product described for its anti-aging properties, among its ingredients coffee seed oil is said to be part of a soothing hydrating blend.

[0010] The present inventors have surprisingly discovered that skin care compositions containing coffee seed oil and 12-hydroxystearic acid provide enhanced anti-inflammatory benefits.

[0011] In a first aspect, the present invention provides a skin care composition comprising: (a) coffee seed oil; and (b) Hydroxy-substituted C8-C 24 fatty acid (this is 12-hydroxystearic acid); Here, coffee seed oil and hydroxy-substituted C8-C 24 The weight ratio of the fatty acids is 1:5 to 15:1.

[0012] In a second aspect, the present invention provides a method of providing at least one benefit selected from anti-inflammatory, anti-aging and anti-acne comprising applying a composition of the present invention to the skin of an individual.

[0013] In a third aspect, the present invention provides the use of a composition of the present invention to provide at least one benefit selected from anti-inflammatory, anti-aging and anti-acne.

[0014] In a fourth aspect, the present invention provides a composition of the present invention for use in providing at least one benefit selected from anti-inflammatory, anti-ageing and anti-acne.

[0015] In a fifth aspect, the present invention provides the use of a composition of the present invention in the manufacture of a medicament for providing at least one benefit selected from anti-inflammatory, anti-ageing and anti-acne.

[0016] All other aspects of the present invention will become more readily apparent in light of the detailed description and examples which follow. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] Except in the examples or where otherwise expressly indicated, all numbers giving amounts of ingredients or reaction conditions, physical properties and / or uses of ingredients herein can be understood as being modified, in some cases, by the word "about."

[0018] All amounts are by weight of the composition unless otherwise indicated.

[0019] It should be noted that when specifying any range of values, any particular upper limit value may be associated with any particular lower limit value.

[0020] For the avoidance of doubt, the word "comprising" is intended to mean "including" but not necessarily "consisting of" or "composed of." In other words, the listed steps or options need not be exhaustive.

[0021] The disclosure of the invention found in this specification is deemed to encompass all embodiments that may be found in claims that are multiple dependent with respect to each other, regardless of the fact that the claims may be found to be free of multiple dependencies or redundancies.

[0022] Coffee Seed Oil Coffee seed oil is an oil extracted from the beans of certain Coffea species. It can be extracted from unroasted or roasted coffee beans. Coffee seed oil is rich in saturated and unsaturated fatty acids and tocopherols. Due to these properties, coffee seed oil is sometimes used in skin care products. The composition of coffee seed oil varies depending on the manufacturing process and the Coffea species. For example, unroasted coffee seed oil can contain high levels of fatty acids, vitamins and caffeine.

[0023] Koffee'UP by Givaudan TM Koffee'UP is the oil of roasted arabica seeds. It is produced by drying spent coffee grounds and by supercritical CO2 extraction. TM is claimed to protect the skin and help it stay moisturized.

[0024] The composition of the present invention comprises coffee seed oil, preferably extracted from roasted seeds of coffee, more preferably extracted from roasted seeds of coffee selected from coffee arabica, coffee canephora and coffee liberic, most preferably extracted from roasted seeds of coffee arabica.

[0025] Preferably, the coffee seed oil is used in the composition in an amount of 0.00001 to 1% by weight of the composition, more preferably 0.0001 to 0.5%, even more preferably 0.0005 to 0.2%, and most preferably 0.001 to 0.05%.

[0026] Hydroxy-substituted C 8 -C 24 fatty acid The hydroxystearic acid of the present invention is 12-hydroxystearic acid (12HSA).

[0027] Preferably, the hydroxy-substituted C8-C 24 The amount of fatty acid is within the range of 0.000001 to 5%, more preferably 0.00001 to 1%, even more preferably 0.00005 to 0.2%, even more preferably 0.0001 to 0.01% based on the weight of the composition.

[0028] Preferably, the amount of 12-hydroxystearic acid (12HSA) is in the range of 0.000001 to 5%, more preferably 0.00001 to 1%, even more preferably 0.00005 to 0.2%, even more preferably 0.0001 to 0.01% by weight of the composition.

[0029] The coffee seed oil and the hydroxy-substituted C8-C 24 The weight ratio of the fatty acids is 1:5 to 15:1, preferably 1:4 to 10:1.

[0030] Preferably, the weight ratio of the coffee seed oil to the 12-hydroxystearic acid is from 1:5 to 15:1, more preferably from 1:4 to 10:1.

[0031] Additionally, it is within the scope of the present invention to include salts of 12-hydroxystearic acid, particularly the sodium salt, however, it is preferred that the 12-hydroxystearic acid is free 12-hydroxystearic acid.

[0032] Skin Benefit Agents The compositions of the present invention may also preferably further comprise a skin benefit agent selected from vitamin B3 compounds, resorcinol compounds, and mixtures thereof.

[0033] Vitamin B3 compounds (including derivatives of vitamin B3), such as niacin, nicotinic acid, picolinamide, isonicotinamide or niacinamide, are preferred skin benefit agents according to the present invention, most preferably niacinamide. When used, vitamin B3 compounds are preferably present in an amount within the range of 0.1 to 10% by weight of the composition, more preferably 0.2 to 5% by weight.

[0034] The resorcinol compound includes resorcinol and its derivatives. Preferably, the resorcinol derivative is a 4-substituted resorcinol derivative selected from the group consisting of 4-straight-chain alkylresorcinol, 4-branched-chain alkylresorcinol, 4-cycloalkylresorcinol, and mixtures thereof. More preferably, the 4-substituted resorcinol derivative is 4-methylresorcinol, 4-ethylresorcinol, 4-propylresorcinol, 4-butylresorcinol, 4-pentylresorcinol, 4-hexylresorcinol, 4-heptylresorcinol, 4-octylresorcinol, 4-nonylresorcinol, 4-decylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-cycloheptylresorcinol, 4-cyclooctylresorcinol, or mixtures thereof. Most preferably, the 4-substituted resorcinol derivative is 4-hexylresorcinol.

[0035] Carrier The composition of the present invention can include a cosmetically acceptable carrier.Water is the most common carrier.Oil carrier in the presence of water and emulsifier forms emulsion system as carrier.These systems can be either water-in-oil emulsion or oil-in-water emulsion, preferably oil-in-water emulsion.Besides water, suitable carrier classes include silicone, hydrocarbon, polyhydric alcohol, fatty alcohol, triglyceride or their mixtures.

[0036] Silicones, when present, may range from 5 to 60%, more preferably from 5 to 40%, by weight of the composition. These silicones may be organic, silicone-containing or fluorine-containing, volatile or non-volatile, polar or non-polar.

[0037] Particularly preferred volatile silicone oils are cyclic volatile silicones having repeat units ranging from 3 to 5; and linear silicones having repeat units ranging from 1 to 7. Highly preferred examples of volatile silicone oils include cyclomethicones of various viscosities, such as Dow Corning 200, Dow Corning 244, Dow Corning 245, Dow Corning 344 and Dow Corning 345 (available from Dow Corning Corp.); SF-1204 and SF-1202 silicone fluids, GE 7207 and 7158 (available from GE Silicones), and SWS-03314 (available from SWS Silicones Corp.).

[0038] Hydrocarbons include mineral oil, petrolatum, and polyalphaolefins. Examples of preferred volatile hydrocarbons include polydecanes, such as isododecane and isodecane (e.g., Permethyl-99A available from Presperse Inc.), and C7-C8-C 12 -C 15 and isoparaffins (eg, the Isopar Series available from Exxon Chemicals).

[0039] Polyhydric alcohols include propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isoprene glycol, ethoxylated glycerol, propoxylated glycerol, and mixtures thereof. Most preferred is glycerol, also known as glycerin. The amount of polyhydric alcohol may range from 0.1 to 10% by weight of the composition, preferably 0.4 to 5% by weight.

[0040] Fatty alcohols may also be present. The term "fatty alcohol" refers to alcohols having a carbon chain length ranging from 10 to 30 carbon atoms. Examples of this category are lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, and combinations thereof. Cetyl alcohol is more preferred.

[0041] Exemplary triglycerides include, but are not limited to, sunflower seed oil, cottonseed oil, canola oil, soybean oil, castor oil, borage oil, olive oil, shea butter, jojoba oil, and mixtures thereof. Mono- and di-glycerides may also be useful. Particularly preferred are glyceryl monostearate and glyceryl distearate.

[0042] The composition may contain water in an amount of 10 to 90% by weight of the composition, preferably 35 to 85% by weight, and more preferably 40 to 70% by weight of the composition.

[0043] The composition may include optional ingredients such as preservatives, antioxidants, colorants, fragrances, or combinations thereof.

[0044] Suitable preservatives for the present invention include alkyl esters of parahydroxybenzoic acid, isothiazolinones, DMDM ​​hydantoin derivatives, propionate salts, and various quaternary ammonium compounds such as iodopropynyl butylcarbamate, phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, and benzyl alcohol.

[0045] Suitable antioxidants for the present invention include vitamin C, vitamin E, CoQ10, and polyphenols derived from various natural sources (eg, tea and grapes).

[0046] viscosity As used herein, "viscosity" refers to dynamic viscosity at 25°C and is reported as mPa·s. A suitable method for measuring viscosity is using a stress-controlled MCR 501 rheometer (Anton Paar, Physica MCR501, Austria) fitted with a sandblasted parallel geometry (PP25s) at a shear rate of 3.98 l / s.

[0047] The viscosity of the composition is suitably in the range of 1,000 to 20,000 mPa·s, preferably in the range of 2,000 to 15,000 mPa·s, and more preferably in the range of 2,500 to 12,000 mPa·s.

[0048] Methods and uses of skin care compositions Skin care compositions as used herein include compositions for topical application to mammalian (especially human) skin. Such compositions may be of the leave-on or wash-off type. Wash-off types are sometimes also referred to as rinse-off types. Leave-on compositions refer to compositions that are applied to the desired skin surface, left on for, e.g., 1 minute to 24 hours, and then wiped off or washed off with water, usually in the course of regular personal washing. Wash-off compositions refer to compositions that are applied to the desired skin surface for a short period of time (e.g., seconds to minutes), and contain sufficient surfactants to aid in cleaning the surface, usually to be washed off with copious amounts of water. The compositions of the present invention are in the form of liquids, lotions, creams, foams, scrubs, or gels.

[0049] The term "skin" as used herein includes the skin of the face (excluding eyelids and lips), neck, chest, abdomen, back, arms, armpits, hands and legs. Preferably, "skin" means the skin of the face (excluding eyelids and lips) and armpits, more preferably, skin means the skin of the face except the lips and eyelids.

[0050] The present invention further relates to a method for producing at least one benefit selected from the group consisting of anti-inflammatory, anti-aging, and anti-acne, comprising administering to a patient a composition comprising coffee seed oil and a hydroxy-substituted C8-C 24 Skin care compositions containing fatty acids are also provided.

[0051] The present invention further relates to a method for the preparation of a medicament for providing at least one benefit selected from anti-inflammatory, anti-aging, and anti-acne, comprising combining coffee seed oil with a hydroxy-substituted C8-C 24 The use of combinations of fatty acids is also provided.

[0052] The present invention further relates to a method for the preparation of a hydroxy-substituted C8-C glycerin-based oil comprising the steps of: providing at least one benefit selected from anti-inflammatory, anti-aging, and anti-acne; 24 Uses of compositions comprising fatty acids are also provided.

[0053] Preferably, the method is non-therapeutic. Preferably, the use is non-therapeutic. The term "non-therapeutic" means for cosmetic purposes and not for curative or therapeutic purposes.

[0054] In the context of the present invention, "cosmetics" is intended to mean a non-medicinal, non-therapeutic use that is not aimed at the prevention and / or treatment of skin conditions that are assessed as pathological by a specialist in the field, such as a dermatologist. For example, when the present invention is applied to the prevention of skin aging, it is a non-therapeutic use starting from a non-pathological condition.

[0055] The following examples are provided to facilitate understanding of the invention and are not intended to limit the scope of the claims. EXAMPLES

[0056] Koffee'UP used in the examples TM (Coffea arabica seed oil) was obtained from Givaudan France SAS.

[0057] 12HSA was purchased from Sigma-Aldrich (Cat No. 219967).

[0058] Human immune cell line THP-1 in vitro assay The anti-inflammatory effect was measured using the following procedure: THP1-XBlue TM (Cat No. thpx-sp, InvivoGen, San Diego, CA) cells were cultured as suspension in RPMI 1640 medium (Cat No. 15140122, Invitrogen, Carlsbad, CA) supplemented with 10% fetal bovine serum (FBS), penicillin (10 U / mL)-streptomycin (10 μg / mL). Cells were cultured at 5 × 10 5 At a density of 100 cells / well, cells were differentiated with 100 nM phorbol-12-myristate-13-acetate for 72 hours. Cells were then co-treated with pure E. coli lipopolysaccharide (LPS, Cat No. L2630, Sigma-Aldrich) and various compositions in Table 1. After 24 hours, the supernatants were collected and interleukin (IL)-6 was measured as a pro-inflammatory biomarker using an enzyme-linked immunosorbent assay kit (Cat No. 555220, BD Biosciences, San Diego, CA). IL-6 expression was calculated as a percentage of LPS-treated cells (which was set as 100%). P values ​​were analyzed by Student's t-test comparing the combination group with the individual compound groups (IL-6 expression, 3 replicates per group). P values ​​< 0.05 indicate an enhanced effect.

[0059] The results regarding IL-6 expression (%) are shown in Table 1.

[0060] [Table 1]

[0061] From the above table, it is clear that Example 1 within the scope of the present invention enhances the suppression of IL-6 expression in THP-1 cells compared to examples outside the scope of the present invention (Examples D and G).

Claims

1. 1. A skin care composition comprising: (a) coffee seed oil; and, (b) Hydroxy-substituted C ８ -C ２４ a fatty acid, which is 12-hydroxystearic acid; Including, Here, coffee seed oil and hydroxy-substituted C ８ -C ２４ The weight ratio of fatty acids is 1:5 to 15:1; The skin care composition.

2. 2. The composition of claim 1, wherein the composition comprises coffee seed oil extracted from roasted seeds of coffee, preferably coffee seed oil extracted from roasted seeds of a coffee tree selected from Coffea arabica, Coffea canephora, and Coffea liberic, and more preferably coffee seed oil extracted from roasted seeds of Coffea arabica.

3. 3. The composition of claim 1, wherein the coffee seed oil is present in an amount of 0.00001 to 1% by weight of the composition.

4. The hydroxy-substituted C ８ -C ２４ 10. The composition of claim 1, wherein the fatty acid is present in an amount of 0.000001 to 5% by weight of the composition.

5. 2. The composition of claim 1, wherein the weight ratio of said coffee seed oil to said 12-hydroxystearic acid is from 1:4 to 10:

1.

6. The composition of claim 1 , wherein the composition further comprises an additional skin benefit agent.

7. 7. The composition of claim 6, wherein the skin benefit agent is selected from vitamin B3 compounds, resorcinol compounds, and mixtures thereof.

8. 10. The composition of claim 1, wherein the composition comprises water, preferably in an amount of 10 to 90% by weight of the composition, and more preferably in an amount of 35 to 85% by weight of the composition.

9. The composition of claim 1, wherein the viscosity of the composition is in the range of 1,000 to 20,000 mPa·s.

10. 2. The composition according to claim 1, wherein the composition is a leave-on or wash-off composition, preferably a wash-off composition.

11. The composition of claim 1 , wherein the composition is in the form of a liquid, lotion, cream, foam, scrub, or gel.

12. The composition of claim 1 , wherein the composition comprises a carrier, preferably a water-in-oil emulsion or an oil-in-water emulsion, more preferably an oil-in-water emulsion.

13. 10. A method for providing at least one benefit selected from anti-inflammatory, anti-aging, and anti-acne, comprising applying the composition of claim 1 to the skin of an individual.