Kit, device, and method for lung cancer detection

Abstract

To provide a kit for detection of lung cancer, comprising a nucleic acid capable of specifically binding to a particular polynucleotide or a polynucleotide complementary to the polynucleotide, which is used for examining the presence or absence of lung cancer in a subject, and a method for assisting in the detection of lung cancer.SOLUTION: The present invention provides a lung cancer detection kit comprising a nucleic acid probe capable of specifically binding to a polynucleotide of miR-3619-3p, which is a lung cancer marker, and / or a primer specifically recognizing and amplifying the polynucleotide, wherein the nucleic acid probe and / or primer is a polynucleotide comprising a specific base sequence, or a polynucleotide consisting of a base sequence exhibiting at least 90% identity with the polynucleotide.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a specific peptide used for testing the presence or absence of lung cancer in a subject. capable of specifically binding to a polynucleotide or a polynucleotide complementary to said polynucleotide A kit or device for detecting lung cancer, which contains a nucleic acid capable of detecting the miRNA, and a method for detecting the miRNA using the nucleic acid The present invention relates to a method for detecting lung cancer, comprising measuring the expression level of A. [Background technology]

[0002] Lung cancer occurs when some cells in the trachea, bronchi, or alveoli of the lungs become cancerous due to some cause. In Japan in 2012, the National Cancer Center's Cancer Control and Information Center disclosed According to statistics on cancer by site, the number of people affected by lung cancer was 107,241, of which 10 It is estimated that one in every 22 men will suffer from lung cancer, and one in every 22 women will suffer from it. The total number of deaths from cancer in the United States in 2014 was 71,518. The estimated number of people affected by lung cancer is 224,210, of which approximately 159,260 will die. It is said.

[0003] There are multiple types of lung cancer histology, with small cell lung cancer accounting for approximately 15% of cases, and the remaining histology types Non-small cell lung cancer is a type of lung cancer that includes a variety of histological types, including adenocarcinoma, squamous cell carcinoma, and The three main histological types of lung cancer are endothelial cell carcinoma, large cell carcinoma, and peritoneal carcinoma. The progression pattern, speed, and symptoms vary greatly, and the appropriate treatment methods are also different. For example, small cell carcinoma It is a fast-growing, highly malignant cancer, but is more responsive to chemotherapy and radiation therapy than non-small cell lung cancer. In addition, lung cancer is classified according to the site of origin, mainly into hilar and There is a pulmonary type. Compared to the pulmonary type occurring in the periphery of the lung, there is a type occurring near the hilum where various trachea gather. The hilar type that occurs is difficult to detect by routine x-ray examination.

[0004] The progression of lung cancer is classified into tumor spread (T1-4), lymph node metastasis (N0-3), and distant metastasis. Depending on the severity (M0, M1), stage 0, IA, IB, IIA, IIB, IIIA Lung cancer is classified into three types: IIIB, IIIC, and IV. The survival rate of lung cancer varies depending on the stage of progression. The 5-year relative survival rate for stage I (IA and IB) was 45-49%, and for stage II ( In stage IIA and IIB), 30-31% and in stage III (IIIA and IIIB), 5 The incidence rates for stage IV and stage IV lung cancers are reported to be 1% and 2%, respectively. If it can be detected and treated at stage 0 or stage I, it can greatly improve survival rates.

[0005] Treatment for lung cancer is centered on surgical resection, radiation therapy, and chemotherapy. Surgery is now possible and there is a high chance of a full recovery. Also, if the cancer is in its early stages, There are several treatment options, including thoracoscopic surgery, stereotactic body radiation therapy (SBRT), There are a number of treatments available to patients, including photodynamic therapy, laser therapy, and brachytherapy, which delivers radiation from within the body. Less invasive treatments may also be possible.

[0006] Regardless of the stage of lung cancer, it often shows almost no symptoms, so early detection through regular checkups is recommended. The most widely used lung cancer screening test is a chest X-ray. If any suspicious findings are found, more detailed imaging such as CT, MRI, or PET scans may be required. In recent years, the effectiveness of lung cancer screening using low-dose CT has been recognized. In the National Lung Screening Trial conducted in the United States, For subjects with a high risk of lung cancer, such as smokers, CT scans were performed compared to chest X-rays. It has been shown that lung cancer mortality was reduced in those who received the treatment.

[0007] If imaging diagnosis indicates a strong suspicion of lung cancer, cells or tissues are taken and examined under a microscope. The final diagnosis, including the histological type of lung cancer, is determined by the examination using cytology and histology. Tests for diagnosis include sputum cytology, pleural fluid testing, bronchoscopy, and percutaneous needle biopsy.

[0008] On the other hand, with existing diagnostic methods, lung cancer is often discovered at an advanced stage, and Therefore, a simpler method is to use tumor markers in the blood. There are efforts to detect lung cancer at an earlier stage. Tumor markers include CEA, CYFRA21-1, NSE, and SCC. In addition, although it is still in the research stage, as shown in Patent Documents 1 to 6 and Non-Patent Documents 1 to 6, The expression levels of microRNAs (miRNAs) in biological samples, including lung fluid, can be used to determine the There have been reports of methods to detect

[0009] Specifically, Patent Document 1 describes miR-1343-3p and miR-6746-5 in serum. p, miR-187-5p, miR-4632-5p, etc., were used to study the effects of the IL-187-5p antibody on healthy subjects and non-lung cancer subjects. A method is presented to distinguish between patients with primary cancer and those with lung cancer.

[0010] Patent Document 2 describes miR-296-5p, miR-422a, and miR -638, miR-191-5p, miR-23a-3p, miR-24-3p, miR Using pairs of expression levels of miR-320a, miR-29b-3p, and miR-92-3p in the lungs, A method for identifying cancer is presented.

[0011] Patent Document 3 describes miR-150-3p, miR-103a-3p, and miR- 107 has been shown to be a biomarker for non-small cell lung cancer.

[0012] Patent Document 4 describes miR-23b-3p, miR-29b-3p, and miR-6 in peripheral blood. A method for identifying non-small cell lung cancer using miR-25-3p, miR-17-3p, etc. has been shown. There are.

[0013] Patent document 5 describes miR-1249-3p, miR-1275, and miR-1 in tracheal cells. 91-5p, miR-423-5p, miR-744, miR-874-3p, etc. This paper presents methods for diagnosing lung cancer and predicting its prognosis.

[0014] Patent Document 6 describes miR-23b-3p, miR-107, and miR-103a- in plasma. Using miR-3p, miR-17-5p, etc., we can detect lung cancer in people who smoke a lot and have a high risk of lung cancer. A method for detecting patients is presented.

[0015] Non-patent literature 1 reports 20 miRs, including miR-1290 and miR-24-3p, in serum. A method has been presented to distinguish lung adenocarcinoma from healthy subjects and benign lung diseases using RNA.

[0016] Non-patent literature 2 reports on the expression of five miRNAs, including miR-650, in bronchoalveolar lavage samples. The amount of this compound was significantly increased in lung cancer patients, and it may be used as a lung cancer marker. As shown.

[0017] Non-patent literature 3 describes miR-3180-3p and miR-342- contained in neutrophil granulocytes. A method for distinguishing between lung cancer patients and healthy individuals using the expression levels of 5p, miR-150, etc. has been shown. is.

[0018] Non-patent literature 4 indicates that serum miR-550 and other substances are biomarkers for lung adenocarcinoma. It is being done.

[0019] Non-patent literature 5 reports that serum miR-1229 and other substances are biomarkers for non-small cell lung cancer. It is shown as follows.

[0020] Non-patent literature 6 reports on serum miR-1254, miR-1275, miR-320a, etc. These have been shown to be biomarkers for non-small cell lung cancer. [Prior art documents] [Patent documents]

[0021] [Patent Document 1] International Publication No. 2015 / 194610 [Patent Document 2] Special Publication No. 2013-502931 [Patent Document 3] Special Publication No. 2011-505143 [Patent Document 4] US Patent Application Publication No. 2012 / 108462 [Patent Document 5] US Patent Application Publication No. 2015 / 080243 [Patent Document 6] International Publication No. 2015 / 115923 [Non-patent literature]

[0022] [Non-Patent Document 1] Tai MC et al. Sci Rep. 2016 Aug 10;6:31389 [Non-Patent Document 2] Schmidt B et al. Adv Exp Med Biol. 2016;924:33-37. [Non-Patent Document 3] Leidinger P et al. Oncotarget. 2014 Oct 15;5(19):9484-97. [Non-Patent Document 4] Rani S et al. Cancer Biol Ther. 2013 Dec;14(12):1104-12. [Non-Patent Document 5] Roth C et al. PLoS One. 2012;7(6):e38248 [Non-Patent Document 6] Foss KM et al. J Thorac Oncol. 2011 Mar;6(3):482-8 Summary of the Invention [Problem to be solved by the invention]

[0023] The object of the present invention is to find a novel lung cancer tumor marker that can be used for the primary examination of lung cancer, The present invention provides a method for effectively detecting lung cancer using nucleic acids for detecting the marker. The requirements for an effective primary lung cancer test are: 1. early detection; 2. 3. High sensitivity and specificity for detecting lung cancer; 4. Low invasiveness The objective is to provide a testing method that satisfies these four points.

[0024] X-ray examinations, which are currently the primary method of screening for lung cancer, are used to detect lesions that occur mainly in the hilar region of the lung. It is difficult to detect small cell carcinoma and squamous cell carcinoma early. Large cell carcinoma also grows quickly and is difficult to detect. In many cases, by the time the tumor is detected, it is already a large cancer. Although it is detected, there are many cases where additional testing reveals that it is not cancer (false positive), This can lead to highly invasive needle biopsies and surgery.

[0025] Blood tumor markers for detecting lung cancer include CEA and CYFRA21-1. However, the general sensitivity of these blood tumor markers for detecting lung cancer is 6 9% in the CYFRA21-1 study and 43% in the CYFRA21-1 study, indicating that the usefulness of the study as a lung cancer test is low. In addition, tumor markers such as CEA and CYFRA21-1 are elevated for reasons other than lung cancer. It is difficult to identify the type of cancer because other cancers may be mistakenly diagnosed as lung cancer. This can result in missed opportunities for appropriate treatment or in unnecessary financial costs to patients due to incorrect medical care. This can result in a heavy physical burden.

[0026] In addition, although it is still in the research stage, microRNAs (miRNAs) in biological samples such as blood There are reports on the use of RNA expression levels to distinguish between lung cancer and other types of cancer. We haven't reached that point yet.

[0027] Patent Document 1 describes miR-1343-3p, miR-6746-5p, and miR -187-5p, miR-4632-5p, etc. were used to study healthy subjects and patients with cancer other than lung cancer. A method for distinguishing between adenocarcinoma and squamous cell carcinoma has been shown to be effective in lung cancer patients. It only contains a sample and may not detect other types of lung cancer.

[0028] Patent Document 2 describes the expression of miR-296-5p, miR-422a, and miR-1 in serum or plasma. R-638, miR-191-5p, miR-23a-3p, miR-24-3p, mi Using pairs of expression levels of miR-320a, miR-29b-3p, miR-92-3p, etc. Although a method for identifying lung cancer is presented, no cancer samples other than lung cancer are used in the examples. , there is a possibility that other cancers may be misidentified as lung cancer.

[0029] Patent Document 3 describes miR-150-3p, miR-103a-3p, and miR Although α-107 and other markers have been shown to be biomarkers for non-small cell lung cancer, There is no description of the specific accuracy, sensitivity, specificity, and other detection performance, and the industrial practicality is poor. It is nice.

[0030] Patent Document 4 describes miR-23b-3p, miR-29b-3p, and miR- A method for identifying non-small cell lung cancer using 625-3p, miR-17-3p, etc. has been shown. However, the examples do not use samples from cancers other than lung cancer or small cell carcinoma, and the There is a possibility that some types of lung cancer, such as small cell lung cancer, may be misidentified as lung cancer, and some types of lung cancer, such as small cell lung cancer, may not be detected. .

[0031] Patent Document 5 describes miR-1249-3p, miR-1275, and miR- 191-5p, miR-423-5p, miR-744, miR-874-3p, etc. Although methods for diagnosing lung cancer and predicting prognosis have been shown, obtaining tissue samples is difficult. Surgical removal of tissue is necessary, and this process places a heavy physical burden on the patient. This is not a preferred testing method.

[0032] Patent Document 6 describes miR-23b-3p, miR-107, and miR-103a in plasma. Using miR-3p, miR-17-5p, etc., the lungs of people who smoked a lot and had a high risk of lung cancer were Although a method for detecting cancer patients is presented, the examples do not use cancer samples other than lung cancer. , there is a possibility that other cancers may be misidentified as lung cancer.

[0033] Non-Patent Document 1 reports that 20 miRs, including miR-1290 and miR-24-3p, are present in serum. A method for distinguishing lung adenocarcinoma from healthy subjects and benign lung diseases using iRNA has been shown, but The discrimination rate for epithelial cancer and small cell carcinoma is low at about 70%, and some lung cancer tissue types are overlooked. There is a possibility that.

[0034] Non-Patent Document 2 reports on the expression of five miRNAs, including miR-650, in bronchoalveolar lavage samples. The amount of IL-1 is significantly increased in lung cancer patients, and it may be used as a lung cancer marker. However, the specific accuracy, sensitivity, specificity, and other detection performance for lung cancer discrimination have not been reported. There is no description of the above, and the invention lacks industrial applicability.

[0035] Non-patent literature 3 describes miR-3180-3p and miR-342 contained in neutrophil granulocytes. A method for distinguishing between lung cancer patients and healthy individuals using the expression levels of miR-5p, miR-150, etc. has been shown. However, separating immune cell types from blood is time-consuming and has little practical industrial application. stomach.

[0036] Non-patent literature 4 indicates that serum miR-550 and other substances are biomarkers for lung adenocarcinoma. However, the examples do not use cancer samples other than lung cancer or lung cancer samples other than adenocarcinoma. However, there is a possibility that other cancers may be misidentified as lung cancer and that some histological types of lung cancer may not be detected. be.

[0037] Non-patent literature 5 reports that serum miR-1229 and other substances are biomarkers for non-small cell lung cancer. However, the examples do not use cancer samples other than lung cancer or small cell carcinoma samples. There is a possibility that other cancers may be misidentified as lung cancer and that some histological types of lung cancer may not be detected. There is.

[0038] Non-patent literature 6 reports on the effects of miR-1254, miR-1275, and miR-320a in serum. These have been shown to be biomarkers for non-small cell lung cancer, but examples show that other cancers besides lung cancer are As a result, there is a possibility that other cancers may be misidentified as lung cancer, and there is a possibility that small cell carcinoma samples or small cell carcinoma samples may be misclassified as lung cancer. It may not detect some lung cancers, such as alveolar cancer.

[0039] In this way, chest X-rays and low-dose CT scans used in lung cancer screening can detect the site of lung cancer. Depending on the type of cancer, it may be difficult to detect, and abnormalities that are not cancer may be found on the images, resulting in unnecessary additional work. In addition, existing tumor markers have low detection performance for lung cancer. Furthermore, the markers under investigation are not sufficient to distinguish lung cancer from other cancers. Verification using non-cancer cancer samples and some histological types of lung cancer, such as small cell carcinoma and large cell carcinoma Since no validation has been performed using these, it is necessary to consider the effects of using these on healthy subjects and other cancer patients. False positives of patients as lung cancer patients may lead to unnecessary additional testing or missed lung cancer patients. In addition, there is a possibility that treatment opportunities may be missed due to tumor marker measurement. Since collecting lung tissue is highly invasive to patients and undesirable, It is possible to detect the presence or absence of lung cancer in blood, and has high accuracy. Lung cancer markers are needed. In particular, if lung cancer is detected early, the possibility of surgery being indicated is high. In addition, there are multiple treatment options for early-stage lung cancer, and thoracoscopes can be used to significantly improve survival rates. There is also the possibility that treatments that are less invasive for patients, such as lower back surgery and stereotactic body radiation therapy, may be applicable. Therefore, there is a strong demand for a highly sensitive lung cancer marker that can detect even low-stage lung cancer. [Means for solving the problem]

[0040] As a result of intensive research aimed at solving the above problems, the present inventors have discovered a method for detecting pulmonary ... To discover gene markers that can be used as cancer detection markers and to detect these markers Nucleic acids for amplifying the marker, such as a probe capable of specifically binding to the marker, The present invention relates to a method for detecting lung adenocarcinoma by using at least one nucleic acid selected from the group consisting of primers for detecting lung adenocarcinoma. , lung cancer such as squamous cell carcinoma, large cell lung cancer, and small cell lung cancer, The present inventors have found that it is possible to detect the oxidative stress effectively, and have completed the present invention.

[0041] <Summary of the Invention> That is, the present invention has the following features. (1) Lung cancer markers: miR-6787-5p, miR-920, and miR-36 22a-5p, miR-1185-1-3p, miR-4327, miR-5739, m iR-937-5p, miR-1181, miR-1185-2-3p, miR-119 3, miR-1207-5p, miR-1238-5p, miR-1246, miR-1 249-5p, miR-1292-3p, miR-1469, miR-1470, miR -197-5p, miR-208a-5p, miR-2110, miR-211-3p, miR-2467-3p, miR-3122, miR-3141, miR-3156-5 p, miR-3158-5p, miR-3160-5p, miR-3180-3p, mi R-3191-3p, miR-3194-3p, miR-320b, miR-328-5 p, miR-3610, miR-3619-3p, miR-3620-5p, miR-3 70-3p, miR-373-5p, miR-3917, miR-3937, miR-4 259, miR-4281, miR-4294, miR-4419b, miR-4428 miR-4429, miR-4433a-3p, miR-4447, miR-4449 miR-4459, miR-4480, miR-4485-5p, miR-4486 miR-4488, miR-4489, miR-4505, miR-4513, miR- 4515, miR-4530, miR-4535, miR-4635, miR-4640 -5p, miR-4646-5p, miR-4656, miR-4663, miR-46 65-5p, miR-4706, miR-4707-5p, miR-4708-3p, m iR-4710, miR-4718, miR-4722-5p, miR-4727-3p miR-4730, miR-4734, miR-4740-5p, miR-4747- 3p, miR-4749-5p, miR-4755-3p, miR-4763-5p, m iR-4787-3p, miR-5008-5p, miR-5010-5p, miR-5 04-3p, miR-5090, miR-5100, miR-5196-5p, miR- 551b-5p, miR-557, miR-5787, miR-6090, miR-61 24, miR-6132, miR-6510-5p, miR-6511b-5p, miR -6515-3p, miR-654-5p, miR-658, miR-668-5p, m iR-6722-5p, miR-6724-5p, miR-6729-3p, miR-6 737-5p, miR-6756-5p, miR-6762-5p, miR-6763- 3p, miR-6766-5p, miR-6769a-5p, miR-6771-5p, miR-6786-5p, miR-6789-5p, miR-6794-5p, miR- 6796-3p, miR-6797-5p, miR-6800-3p, miR-6802 -5p, miR-6803-5p, miR-6805-3p, miR-6805-5p, miR-6807-5p, miR-6812-5p, miR-6819-5p, miR- 6822-5p, miR-6824-5p, miR-6826-5p, miR-6850 -5p, miR-6858-5p, miR-6861-5p, miR-6880-3p, miR-7107-5p, miR-7109-5p, miR-7114-5p, miR- 7704, miR-7846-3p, miR-8052, miR-8060, miR-8 071, miR-8073, miR-874-5p, miR-204-3p, miR-3 154, miR-3960, miR-4433a-5p, miR-4455, miR-4 462, miR-4476, miR-4508, miR-4687-3p, miR-46 87-5p, miR-4732-5p, miR-4771, miR-642a-3p, m iR-6732-5p, miR-6760-5p, miR-6799-5p, miR-6 820-5p, miR-6821-5p, miR-6829-5p, miR-6893- 5p, miR-7108-3p, miR-7111-5p, miR-8089, miR- At least one polynucleotide selected from the group consisting of miR-885-3p, miR-92b-3p, A polynucleotide having a base sequence complementary to the nucleotide or the polynucleotide is specifically A kit for detecting lung cancer, comprising a heterologously binding nucleic acid. (2) The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, its variant, its derivative, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, its variants, Derivatives or fragments thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions. A hybridizing polynucleotide, The kit according to (1), wherein the polynucleotide is selected from the group consisting of: (3) The kit further comprises another lung cancer marker, miR-1343-3p, miR-6 746-5p, miR-422a, miR-187-5p, miR-4632-5p, m iR-6791-5p, miR-103a-3p, miR-107, miR-1199- 5p, miR-1225-3p, miR-1225-5p, miR-1228-5p, m iR-1229-5p, miR-1233-5p, miR-1237-5p, miR-1 247-3p, miR-1249-3p, miR-1254, miR-1260b, mi R-1268a, miR-1268b, miR-1273g-3p, miR-128-1 -5p, miR-128-2-5p, miR-1290, miR-150-3p, miR -17-3p, miR-1908-5p, miR-1909-3p, miR-1914- 3p, miR-1915-3p, miR-191-5p, miR-22-3p, miR- 23b-3p, miR-24-3p, miR-296-3p, miR-296-5p, m iR-3131, miR-3162-5p, miR-3188, miR-3196, mi R-3197, miR-320a, miR-342-5p, miR-3621, miR- 3648, miR-3656, miR-365a-5p, miR-3665, miR-3 679-5p, miR-371a-5p, miR-3940-5p, miR-423-5 p, miR-4257, miR-4270, miR-4271, miR-4286, mi R-4298, miR-4417, miR-4442, miR-4446-3p, miR -4448, miR-4454, miR-4467, miR-4472, miR-450 7, miR-4516, miR-451a, miR-4649-5p, miR-4651 miR-4665-3p, miR-4674, miR-4675, miR-4689 miR-4695-5p, miR-4697-5p, miR-4725-3p, miR- 4739, miR-4745-5p, miR-4763-3p, miR-4792, mi R-486-3p, miR-5001-5p, miR-5195-3p, miR-550 a-5p, miR-5698, miR-6075, miR-6088, miR-6089 miR-6125, miR-6126, miR-614, miR-615-5p, mi R-619-5p, miR-638, miR-642b-3p, miR-650, miR -663a, miR-663b, miR-6717-5p, miR-6721-5p, and m iR-6726-5p, miR-6727-5p, miR-6738-5p, miR-6 741-5p, miR-6749-5p, miR-6752-5p, miR-675-5 p, miR-6757-5p, miR-6763-5p, miR-6765-5p, mi R-6775-5p, miR-6780b-5p, miR-6782-5p, miR-6 784-5p, miR-6800-5p, miR-6806-5p, miR-6840- 3p, miR-6848-5p, miR-6851-5p, miR-6870-5p, m iR-6872-3p, miR-6875-5p, miR-6877-5p, miR-6 879-5p, miR-6880-5p, miR-6885-5p, miR-6887- 5p, miR-7108-5p, miR-711, miR-7113-3p, miR-7 44-5p, miR-760, miR-7845-5p, miR-7847-3p, mi R-7977, miR-8059, miR-8063, miR-8072, miR-87 4-3p, miR-92a-2-5p, miR-92b-5p, miR-940, miR -1228-3p, miR-1275, miR-1307-3p, miR-1343-5 p, miR-23a-3p, miR-29b-3p, miR-3135b, miR-31 85, miR-4532, miR-4690-5p, miR-4758-5p, miR- 4783-3p, miR-6131, miR-625-3p, miR-6511a-5p miR-6765-3p, miR-6816-5p, miR-6825-5p, miR -6845-5p, miR-7150, miR-7641, miR-7975, miR- At least one polynucleotide selected from the group consisting of 92a-3p or the polynucleotide A nucleic acid capable of specifically binding to a polynucleotide having a base sequence complementary to the nucleotide The kit according to (1) or (2), further comprising: (4) The nucleic acid is a polynucleotide represented by any one of (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases, (g) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, its derivatives or fragments containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions A hybridizing polynucleotide, The kit according to (3), wherein the polynucleotide is selected from the group consisting of: (5) Lung cancer markers: miR-6787-5p, miR-920, and miR-36 22a-5p, miR-1185-1-3p, miR-4327, miR-5739, m iR-937-5p, miR-1181, miR-1185-2-3p, miR-119 3, miR-1207-5p, miR-1238-5p, miR-1246, miR-1 249-5p, miR-1292-3p, miR-1469, miR-1470, miR -197-5p, miR-208a-5p, miR-2110, miR-211-3p miR-2467-3p, miR-3122, miR-3141, and miR-3156-5 p, miR-3158-5p, miR-3160-5p, miR-3180-3p, mi R-3191-3p, miR-3194-3p, miR-320b, miR-328-5 p, miR-3610, miR-3619-3p, miR-3620-5p, miR-3 70-3p, miR-373-5p, miR-3917, miR-3937, miR-4 259, miR-4281, miR-4294, miR-4419b, miR-4428 miR-4429, miR-4433a-3p, miR-4447, miR-4449 miR-4459, miR-4480, miR-4485-5p, miR-4486 miR-4488, miR-4489, miR-4505, miR-4513, miR- 4515, miR-4530, miR-4535, miR-4635, miR-4640 -5p, miR-4646-5p, miR-4656, miR-4663, miR-46 65-5p, miR-4706, miR-4707-5p, miR-4708-3p, m iR-4710, miR-4718, miR-4722-5p, miR-4727-3p miR-4730, miR-4734, miR-4740-5p, miR-4747- 3p, miR-4749-5p, miR-4755-3p, miR-4763-5p, m iR-4787-3p, miR-5008-5p, miR-5010-5p, miR-5 04-3p, miR-5090, miR-5100, miR-5196-5p, miR- 551b-5p, miR-557, miR-5787, miR-6090, miR-61 24, miR-6132, miR-6510-5p, miR-6511b-5p, miR -6515-3p, miR-654-5p, miR-658, miR-668-5p, m iR-6722-5p, miR-6724-5p, miR-6729-3p, miR-6 737-5p, miR-6756-5p, miR-6762-5p, miR-6763- 3p, miR-6766-5p, miR-6769a-5p, miR-6771-5p miR-6786-5p, miR-6789-5p, miR-6794-5p, miR- 6796-3p, miR-6797-5p, miR-6800-3p, miR-6802 -5p, miR-6803-5p, miR-6805-3p, miR-6805-5p miR-6807-5p, miR-6812-5p, miR-6819-5p, miR- 6822-5p, miR-6824-5p, miR-6826-5p, miR-6850 -5p, miR-6858-5p, miR-6861-5p, miR-6880-3p miR-7107-5p, miR-7109-5p, miR-7114-5p, miR- 7704, miR-7846-3p, miR-8052, miR-8060, miR-8 071, miR-8073, miR-874-5p, miR-204-3p, miR-3 154, miR-3960, miR-4433a-5p, miR-4455, miR-4 462, miR-4476, miR-4508, miR-4687-3p, miR-46 87-5p, miR-4732-5p, miR-4771, miR-642a-3p, m iR-6732-5p, miR-6760-5p, miR-6799-5p, miR-6 820-5p, miR-6821-5p, miR-6829-5p, miR-6893- 5p, miR-7108-3p, miR-7111-5p, miR-8089, miR- At least one polynucleotide selected from the group consisting of miR-885-3p, miR-92b-3p, A polynucleotide having a base sequence complementary to the nucleotide or the polynucleotide is specifically A device for detecting lung cancer, comprising a heterologously binding nucleic acid. (6) The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, its variant, its derivative, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, its variants, Derivatives or fragments thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions. A hybridizing polynucleotide, The device according to (5), wherein the polynucleotide is selected from the group consisting of: (7) 6746-5p、miR-422a、miR-187-5p、miR-4632-5p、 miR-6791-5p、miR-103a-3p、miR-107、miR-1199 -5p、miR-1225-3p、miR-1225-5p、miR-1228-5p、 miR-1229-5p、miR-1233-5p、miR-1237-5p、miR- 1247-3p、miR-1249-3p、miR-1254、miR-1260b、m iR-1268a、miR-1268b、miR-1273g-3p、miR-128- 1-5p、eR-128-2-5p、eR-1290、eR-150-3p、e R-17-3p、miR-1908-5p、miR-1909-3p、miR-1914 -3p、miR-1915-3p、miR-191-5p、miR-22-3p、miR -23b-3p、miR-24-3p、miR-296-3p、miR-296-5p、 miR-3131、miR-3162-5p、miR-3188、miR-3196、m iR-3197、miR-320a、miR-342-5p、miR-3621、miR -3648、miR-3656、miR-365a-5p、miR-3665、miR- 3679-5p、miR-371a-5p、miR-3940-5p、miR-423- 5p、miR-4257、miR-4270、miR-4271、miR-4286、m iR-4298、miR-4417、miR-4442、miR-4446-3p、mi R-4448、miR-4454、miR-4467、miR-4472、miR-45 07、miR-4516、miR-451a、miR-4649-5p、miR-465 1, miR-4665-3p, miR-4674, miR-4675, miR-4689 miR-4695-5p, miR-4697-5p, miR-4725-3p, miR -4739, miR-4745-5p, miR-4763-3p, miR-4792, m iR-486-3p, miR-5001-5p, miR-5195-3p, miR-55 0a-5p, miR-5698, miR-6075, miR-6088, miR-608 9, miR-6125, miR-6126, miR-614, miR-615-5p, m iR-619-5p, miR-638, miR-642b-3p, miR-650, mi R-663a, miR-663b, miR-6717-5p, miR-6721-5p miR-6726-5p, miR-6727-5p, miR-6738-5p, miR- 6741-5p, miR-6749-5p, miR-6752-5p, miR-675- 5p, miR-6757-5p, miR-6763-5p, miR-6765-5p, m iR-6775-5p, miR-6780b-5p, miR-6782-5p, miR- 6784-5p, miR-6800-5p, miR-6806-5p, miR-6840 -3p, miR-6848-5p, miR-6851-5p, miR-6870-5p miR-6872-3p, miR-6875-5p, miR-6877-5p, miR- 6879-5p, miR-6880-5p, miR-6885-5p, miR-6887 -5p, miR-7108-5p, miR-711, miR-7113-3p, miR- 744-5p, miR-760, miR-7845-5p, miR-7847-3p, m iR-7977, miR-8059, miR-8063, miR-8072, miR-8 74-3p, miR-92a-2-5p, miR-92b-5p, miR-940, mi R-1228-3p, miR-1275, miR-1307-3p, miR-1343- 5p, miR-23a-3p, miR-29b-3p, miR-3135b, miR-3 185, miR-4532, miR-4690-5p, miR-4758-5p, miR -4783-3p, miR-6131, miR-625-3p, miR-6511a-5 p, miR-6765-3p, miR-6816-5p, miR-6825-5p, mi R-6845-5p, miR-7150, miR-7641, miR-7975, miR At least one polynucleotide selected from the group consisting of -92a-3p or A nucleic acid capable of specifically binding to a polynucleotide having a base sequence complementary to a polynucleotide The device according to (5) or (6), further comprising: (8) The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases, (g) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, its derivatives or fragments containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions A hybridizing polynucleotide, The device according to (7), wherein the polynucleotide is selected from the group consisting of: (9) The device is a device for measurement by hybridization technology. , A device according to any one of (5) to (8). (10) The method according to (9), wherein the hybridization technique is a nucleic acid array technique. Vice. (11) In a subject's sample, the lung cancer marker miR-6787-5p, mi R-920, miR-3622a-5p, miR-1185-1-3p, miR-432 7, miR-5739, miR-937-5p, miR-1181, miR-1185- 2-3p, miR-1193, miR-1207-5p, miR-1238-5p, mi R-1246, miR-1249-5p, miR-1292-3p, miR-1469, miR-1470, miR-197-5p, miR-208a-5p, miR-2110 , miR-211-3p, miR-2467-3p, miR-3122, miR-314 1, miR-3156-5p, miR-3158-5p, miR-3160-5p, mi R-3180-3p, miR-3191-3p, miR-3194-3p, miR-32 0b, miR-328-5p, miR-3610, miR-3619-3p, miR-3 620-5p, miR-370-3p, miR-373-5p, miR-3917, mi R-3937, miR-4259, miR-4281, miR-4294, miR-44 19b, miR-4428, miR-4429, miR-4433a-3p, miR-4 447, miR-4449, miR-4459, miR-4480, miR-4485 5p, miR-4486, miR-4488, miR-4489, miR-4505, m iR-4513, miR-4515, miR-4530, miR-4535, miR-4 635, miR-4640-5p, miR-4646-5p, miR-4656, miR -4663, miR-4665-5p, miR-4706, miR-4707-5p, m iR-4708-3p, miR-4710, miR-4718, and miR-4722-5p miR-4727-3p, miR-4730, miR-4734, miR-4740- 5p, miR-4747-3p, miR-4749-5p, miR-4755-3p, m iR-4763-5p, miR-4787-3p, miR-5008-5p, miR-5 010-5p, miR-504-3p, miR-5090, miR-5100, miR- 5196-5p, miR-551b-5p, miR-557, miR-5787, miR -6090, miR-6124, miR-6132, miR-6510-5p, miR- 6511b-5p, miR-6515-3p, miR-654-5p, miR-658 miR-668-5p, miR-6722-5p, miR-6724-5p, miR-6 729-3p, miR-6737-5p, miR-6756-5p, miR-6762- 5p, miR-6763-3p, miR-6766-5p, miR-6769a-5p miR-6771-5p, miR-6786-5p, miR-6789-5p, miR- 6794-5p, miR-6796-3p, miR-6797-5p, miR-6800 -3p, miR-6802-5p, miR-6803-5p, miR-6805-3p, miR-6805-5p, miR-6807-5p, miR-6812-5p, miR- 6819-5p, miR-6822-5p, miR-6824-5p, miR-6826 -5p, miR-6850-5p, miR-6858-5p, miR-6861-5p, miR-6880-3p, miR-7107-5p, miR-7109-5p, miR- 7114-5p, miR-7704, miR-7846-3p, miR-8052, mi R-8060, miR-8071, miR-8073, miR-874-5p, miR- 204-3p, miR-3154, miR-3960, miR-4433a-5p, mi R-4455, miR-4462, miR-4476, miR-4508, miR-46 87-3p, miR-4687-5p, miR-4732-5p, miR-4771, m iR-642a-3p, miR-6732-5p, miR-6760-5p, miR-6 799-5p, miR-6820-5p, miR-6821-5p, miR-6829- 5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, m iR-8089, miR-885-3p, miR-92b-3p The expression level of at least one polynucleotide corresponding to the target gene is measured, and the measured expression level is used to detect the target gene. In vitro confirmation that subjects have or do not have lung cancer 23. A method for detecting lung cancer, comprising: (12) In a subject's sample, the lung cancer markers miR-6787-5p, mi R-920, miR-3622a-5p, miR-1185-1-3p, miR-432 7, miR-5739, miR-937-5p, miR-1181, miR-1185- 2-3p, miR-1193, miR-1207-5p, miR-1238-5p, mi R-1246, miR-1249-5p, miR-1292-3p, miR-1469 miR-1470, miR-197-5p, miR-208a-5p, miR-2110 miR-211-3p, miR-2467-3p, miR-3122, miR-314 1, miR-3156-5p, miR-3158-5p, miR-3160-5p, mi R-3180-3p, miR-3191-3p, miR-3194-3p, miR-32 0b, miR-328-5p, miR-3610, miR-3619-3p, miR-3 620-5p, miR-370-3p, miR-373-5p, miR-3917, mi R-3937, miR-4259, miR-4281, miR-4294, miR-44 19b, miR-4428, miR-4429, miR-4433a-3p, miR-4 447, miR-4449, miR-4459, miR-4480, miR-4485 5p, miR-4486, miR-4488, miR-4489, miR-4505, m iR-4513, miR-4515, miR-4530, miR-4535, miR-4 635, miR-4640-5p, miR-4646-5p, miR-4656, miR -4663, miR-4665-5p, miR-4706, miR-4707-5p, m iR-4708-3p, miR-4710, miR-4718, and miR-4722-5p miR-4727-3p, miR-4730, miR-4734, miR-4740- 5p, miR-4747-3p, miR-4749-5p, miR-4755-3p, m iR-4763-5p, miR-4787-3p, miR-5008-5p, miR-5 010-5p, miR-504-3p, miR-5090, miR-5100, miR- 5196-5p, miR-551b-5p, miR-557, miR-5787, miR -6090, miR-6124, miR-6132, miR-6510-5p, miR- 6511b-5p, miR-6515-3p, miR-654-5p, miR-658 miR-668-5p, miR-6722-5p, miR-6724-5p, miR-6 729-3p, miR-6737-5p, miR-6756-5p, miR-6762- 5p, miR-6763-3p, miR-6766-5p, miR-6769a-5p miR-6771-5p, miR-6786-5p, miR-6789-5p, miR- 6794-5p, miR-6796-3p, miR-6797-5p, miR-6800 -3p, miR-6802-5p, miR-6803-5p, miR-6805-3p miR-6805-5p, miR-6807-5p, miR-6812-5p, miR- 6819-5p, miR-6822-5p, miR-6824-5p, miR-6826 -5p, miR-6850-5p, miR-6858-5p, miR-6861-5p miR-6880-3p, miR-7107-5p, miR-7109-5p, miR- 7114-5p, miR-7704, miR-7846-3p, miR-8052, mi R-8060, miR-8071, miR-8073, miR-874-5p, miR- 204-3p, miR-3154, miR-3960, miR-4433a-5p, mi R-4455, miR-4462, miR-4476, miR-4508, miR-46 87-3p, miR-4687-5p, miR-4732-5p, miR-4771, m iR-642a-3p, miR-6732-5p, miR-6760-5p, miR-6 799-5p, miR-6820-5p, miR-6821-5p, miR-6829- 5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, m iR-8089, miR-885-3p, miR-92b-3p The expression level of at least one polynucleotide corresponding to the target gene is measured, and the measured expression level and The expression level of the measured normal healthy subjects and the control expression level of the measured normal healthy subjects are used to determine whether the subject is suffering from lung cancer or whether the lung is 23. A method for detecting lung cancer, comprising in vitro assessment of the absence of lung cancer. (13) The presence or absence of lung cancer markers, miR-6787-5p, mi R-920, miR-3622a-5p, miR-1185-1-3p, miR-432 7, miR-5739, miR-937-5p, miR-1181, miR-1185- 2-3p, miR-1193, miR-1207-5p, miR-1238-5p, mi R-1246, miR-1249-5p, miR-1292-3p, miR-1469, miR-1470, miR-197-5p, miR-208a-5p, miR-2110 , miR-211-3p, miR-2467-3p, miR-3122, miR-314 1, miR-3156-5p, miR-3158-5p, miR-3160-5p, mi R-3180-3p, miR-3191-3p, miR-3194-3p, miR-32 0b, miR-328-5p, miR-3610, miR-3619-3p, miR-3 620-5p, miR-370-3p, miR-373-5p, miR-3917, mi R-3937, miR-4259, miR-4281, miR-4294, miR-44 19b, miR-4428, miR-4429, miR-4433a-3p, miR-4 447, miR-4449, miR-4459, miR-4480, miR-4485 5p, miR-4486, miR-4488, miR-4489, miR-4505, m iR-4513, miR-4515, miR-4530, miR-4535, miR-4 635, miR-4640-5p, miR-4646-5p, miR-4656, miR -4663, miR-4665-5p, miR-4706, miR-4707-5p, m iR-4708-3p, miR-4710, miR-4718, and miR-4722-5p miR-4727-3p, miR-4730, miR-4734, miR-4740- 5p, miR-4747-3p, miR-4749-5p, miR-4755-3p, m iR-4763-5p, miR-4787-3p, miR-5008-5p, miR-5 010-5p, miR-504-3p, miR-5090, miR-5100, miR- 5196-5p, miR-551b-5p, miR-557, miR-5787, miR -6090, miR-6124, miR-6132, miR-6510-5p, miR- 6511b-5p, miR-6515-3p, miR-654-5p, miR-658 miR-668-5p, miR-6722-5p, miR-6724-5p, miR-6 729-3p, miR-6737-5p, miR-6756-5p, miR-6762- 5p, miR-6763-3p, miR-6766-5p, miR-6769a-5p, miR-6771-5p, miR-6786-5p, miR-6789-5p, miR- 6794-5p, miR-6796-3p, miR-6797-5p, miR-6800 -3p, miR-6802-5p, miR-6803-5p, miR-6805-3p, miR-6805-5p, miR-6807-5p, miR-6812-5p, miR- 6819-5p, miR-6822-5p, miR-6824-5p, miR-6826 -5p, miR-6850-5p, miR-6858-5p, miR-6861-5p, miR-6880-3p, miR-7107-5p, miR-7109-5p, miR- 7114-5p, miR-7704, miR-7846-3p, miR-8052, mi R-8060, miR-8071, miR-8073, miR-874-5p, miR- 204-3p, miR-3154, miR-3960, miR-4433a-5p, mi R-4455, miR-4462, miR-4476, miR-4508, miR-46 87-3p, miR-4687-5p, miR-4732-5p, miR-4771, m iR-642a-3p, miR-6732-5p, miR-6760-5p, miR-6 799-5p, miR-6820-5p, miR-6821-5p, miR-6829- 5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, m iR-8089, miR-885-3p, miR-92b-3p and measuring the expression level of at least one polynucleotide associated with a lung cancer. Gene expression levels of samples from subjects with lung cancer and those from subjects without lung cancer The expression level was used as a teacher sample, and it was possible to distinguish between the presence or absence of lung cancer. The discriminant capable of determining whether or not at least one polynucleotide in a sample from the subject is a The presence or absence of lung cancer was determined in vitro by substituting the expression level of nucleotides. o. (14) A polynucleotide having a base sequence complementary to the polynucleotide or the polynucleotide. Measurement of the expression level of the polynucleotide using a nucleic acid capable of specifically binding to the polynucleotide and determining whether the nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, its variant, its derivative, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, its variants, Derivatives or fragments thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions. A hybridizing polynucleotide, The polynucleotide according to any one of (11) to (13) above is selected from the group consisting of Method of posting. (15) miR-1343-3p and miR-6746-5p, another lung cancer marker miR-422a, miR-187-5p, miR-4632-5p, miR-679 1-5p, miR-103a-3p, miR-107, miR-1199-5p, miR -1225-3p, miR-1225-5p, miR-1228-5p, miR-122 9-5p, miR-1233-5p, miR-1237-5p, miR-1247-3p miR-1249-3p, miR-1254, miR-1260b, and miR-1268 a, miR-1268b, miR-1273g-3p, miR-128-1-5p, mi R-128-2-5p, miR-1290, miR-150-3p, miR-17-3p miR-1908-5p, miR-1909-3p, miR-1914-3p, miR -1915-3p, miR-191-5p, miR-22-3p, miR-23b-3p miR-24-3p, miR-296-3p, miR-296-5p, miR-313 1, miR-3162-5p, miR-3188, miR-3196, miR-3197 miR-320a, miR-342-5p, miR-3621, miR-3648, and m iR-3656, miR-365a-5p, miR-3665, miR-3679-5p miR-371a-5p, miR-3940-5p, miR-423-5p, miR- 4257, miR-4270, miR-4271, miR-4286, miR-4298 miR-4417, miR-4442, miR-4446-3p, miR-4448 miR-4454, miR-4467, miR-4472, miR-4507, miR- 4516, miR-451a, miR-4649-5p, miR-4651, miR-4 665-3p, miR-4674, miR-4675, miR-4689, miR-46 95-5p, miR-4697-5p, miR-4725-3p, miR-4739, m iR-4745-5p, miR-4763-3p, miR-4792, miR-486- 3p, miR-5001-5p, miR-5195-3p, miR-550a-5p, m iR-5698, miR-6075, miR-6088, miR-6089, miR-6 125, miR-6126, miR-614, miR-615-5p, miR-619- 5p, miR-638, miR-642b-3p, miR-650, miR-663a miR-663b, miR-6717-5p, miR-6721-5p, miR-672 6-5p, miR-6727-5p, miR-6738-5p, miR-6741-5p miR-6749-5p, miR-6752-5p, miR-675-5p, miR- 6757-5p, miR-6763-5p, miR-6765-5p, miR-6775 -5p, miR-6780b-5p, miR-6782-5p, miR-6784-5p miR-6800-5p, miR-6806-5p, miR-6840-3p, miR -6848-5p, miR-6851-5p, miR-6870-5p, miR-687 2-3p, miR-6875-5p, miR-6877-5p, miR-6879-5p miR-6880-5p, miR-6885-5p, miR-6887-5p, miR -7108-5p, miR-711, miR-7113-3p, miR-744-5p miR-760, miR-7845-5p, miR-7847-3p, miR-7977 miR-8059, miR-8063, miR-8072, miR-874-3p, m iR-92a-2-5p, miR-92b-5p, miR-940, miR-1228- 3p, miR-1275, miR-1307-3p, miR-1343-5p, miR- 23a-3p, miR-29b-3p, miR-3135b, miR-3185, miR -4532, miR-4690-5p, miR-4758-5p, miR-4783-3 p, miR-6131, miR-625-3p, miR-6511a-5p, miR-6 765-3p, miR-6816-5p, miR-6825-5p, miR-6845- 5p, miR-7150, miR-7641, miR-7975, miR-92a-3p measuring the expression level of at least one polynucleotide selected from the group consisting of The method according to any one of (11) to (14), further comprising: (16) A polynucleotide having a base sequence complementary to the above-mentioned polynucleotide or the above-mentioned polynucleotide. Measurement of the expression level of the polynucleotide using a nucleic acid capable of specifically binding to the polynucleotide and the nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases, (g) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, its derivatives or fragments containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions A hybridizing polynucleotide, The method according to (15), wherein the polynucleotide is selected from the group consisting of: (17) A polynucleotide having a base sequence complementary to the above polynucleotide or the above polynucleotide. The nucleic acid according to any one of (1) to (4), which comprises a nucleic acid capable of specifically binding to a oligonucleotide. or the device according to any one of (5) to (10), The method according to any one of (11) to (16), wherein the expression level of the polynucleotide is measured. . (18) The method according to any one of (11) to (17), wherein the subject is a human. (19) The sample according to any one of (11) to (18), wherein the sample is blood, serum, or plasma. How to.

[0042] In a preferred embodiment of the present invention, the above-mentioned kit, device or The detection method for lung cancer is to determine whether the histological type of lung cancer is adenocarcinoma, squamous cell carcinoma, large cell carcinoma or small cell carcinoma. The present invention relates to a kit, device, and method for detecting lung cancer, which is a type of cell cancer.

[0043] In another preferred embodiment of the present invention, the above-mentioned lung cancer detection kit, device, The detection method for lung cancer or lung cancer is to detect the presence of miR-6787-5p, a lung cancer marker, in the hsa- miR-6787-5p, miR-920 is hsa-miR-920, R-3622a-5p is hsa-miR-3622a-5p, and miR-1185- 1-3p is hsa-miR-1185-1-3p, and miR-4327 is hsa-m iR-4327, miR-5739 is hsa-miR-5739, miR- 937-5p is hsa-miR-937-5p, and miR-1181 is hsa-mi R-1181, and miR-1185-2-3p is hsa-miR-1185-2-3 p, miR-1193 is hsa-miR-1193, and miR-1207-5 p is hsa-miR-1207-5p and miR-1238-5p is hsa-miR -1238-5p, miR-1246 is hsa-miR-1246, and miR -1249-5p is hsa-miR-1249-5p, and miR-1292-3p is hsa-miR-1292-3p and miR-1469 , miR-1470 is hsa-miR-1470, and miR-197-5p is hsa-miR-197-5p and miR-208a-5p are hsa-miR-20 8a-5p, miR-2110 is hsa-miR-2110, and miR-21 1-3p is hsa-miR-211-3p and miR-2467-3p is hsa-m iR-2467-3p, miR-3122 is hsa-miR-3122, iR-3141 is hsa-miR-3141, and miR-3156-5p is hsa- miR-3156-5p and miR-3158-5p are hsa-miR-3158- 5p, miR-3160-5p is hsa-miR-3160-5p, and miR -3180-3p is hsa-miR-3180-3p, and miR-3191-3p is hsa-miR-3191-3p and miR-3194-3p are hsa-miR-3 194-3p, miR-320b is hsa-miR-320b, and miR-3 28-5p is hsa-miR-328-5p and miR-3610 is hsa-miR -3610, and miR-3619-3p is hsa-miR-3619-3p, miR-3620-5p is hsa-miR-3620-5p and miR-370-3 p is hsa-miR-370-3p and miR-373-5p is hsa-miR-3 73-5p, miR-3917 is hsa-miR-3917, and miR-39 37 is hsa-miR-3937 and miR-4259 is hsa-miR-4259 , miR-4281 is hsa-miR-4281, and miR-4294 is hs a-miR-4294 and miR-4419b is hsa-miR-4419b , miR-4428 is hsa-miR-4428, and miR-4429 is hsa-m iR-4429 and miR-4433a-3p are hsa-miR-4433a-3p , miR-4447 is hsa-miR-4447, and miR-4449 is hs a-miR-4449, miR-4459 is hsa-miR-4459, m iR-4480 is hsa-miR-4480 and miR-4485-5p is hsa- miR-4485-5p, miR-4486 is hsa-miR-4486, miR-4488 is hsa-miR-4488 and miR-4489 is hsa-mi R-4489, miR-4505 is hsa-miR-4505, and miR-4 513 is hsa-miR-4513 and miR-4515 is hsa-miR-451 5, miR-4530 is hsa-miR-4530, and miR-4535 is hsa-miR-4530. sa-miR-4535 and miR-4635 is hsa-miR-4635; miR-4640-5p is hsa-miR-4640-5p, and miR-4646- 5p is hsa-miR-4646-5p and miR-4656 is hsa-miR-4 656, miR-4663 is hsa-miR-4663, and miR-4665 -5p is hsa-miR-4665-5p, and miR-4706 is hsa-miR- 4706, miR-4707-5p is hsa-miR-4707-5p, and m iR-4708-3p is hsa-miR-4708-3p and miR-4710 is hsa sa-miR-4710 and miR-4718 is hsa-miR-4718; miR-4722-5p is hsa-miR-4722-5p, and miR-4727- 3p is hsa-miR-4727-3p, and miR-4730 is hsa-miR-4 730, miR-4734 is hsa-miR-4734, and miR-4740 -5p is hsa-miR-4740-5p and miR-4747-3p is hsa-m iR-4747-3p and miR-4749-5p are hsa-miR-4749-5 p, miR-4755-3p is hsa-miR-4755-3p, and miR- 4763-5p is hsa-miR-4763-5p and miR-4787-3p is hsa sa-miR-4787-3p and miR-5008-5p are hsa-miR-50 08-5p, and miR-5010-5p is hsa-miR-5010-5p; miR-504-3p is hsa-miR-504-3p and miR-5090 is hs a-miR-5090, miR-5100 is hsa-miR-5100, m iR-5196-5p is hsa-miR-5196-5p and miR-551b-5 p is hsa-miR-551b-5p and miR-557 is hsa-miR-557 , miR-5787 is hsa-miR-5787, and miR-6090 is hs a-miR-6090, miR-6124 is hsa-miR-6124, m iR-6132 is hsa-miR-6132 and miR-6510-5p is hsa- miR-6510-5p and miR-6511b-5p are hsa-miR-6511 b-5p, miR-6515-3p is hsa-miR-6515-3p, m iR-654-5p is hsa-miR-654-5p, and miR-658 is hsa- miR-658, and miR-668-5p is hsa-miR-668-5p; miR-6722-5p is hsa-miR-6722-5p, and miR-6724- 5p is hsa-miR-6724-5p and miR-6729-3p is hsa-mi miR-6729-3p and miR-6737-5p are hsa-miR-6737-5p and miR-6756-5p is hsa-miR-6756-5p and miR-6 762-5p is hsa-miR-6762-5p and miR-6763-3p is hs a-miR-6763-3p and miR-6766-5p are hsa-miR-676 6-5p, miR-6769a-5p is hsa-miR-6769a-5p , miR-6771-5p is hsa-miR-6771-5p, and miR-6786 -5p is hsa-miR-6786-5p and miR-6789-5p is hsa-m iR-6789-5p and miR-6794-5p are hsa-miR-6794-5 p, miR-6796-3p is hsa-miR-6796-3p, and miR- 6797-5p is hsa-miR-6797-5p and miR-6800-3p is h sa-miR-6800-3p and miR-6802-5p are hsa-miR-68 02-5p, and miR-6803-5p is hsa-miR-6803-5p; miR-6805-3p is hsa-miR-6805-3p, and miR-6805- 5p is hsa-miR-6805-5p and miR-6807-5p is hsa-mi miR-6807-5p and miR-6812-5p are hsa-miR-6812-5p and miR-6819-5p is hsa-miR-6819-5p and miR-6 822-5p is hsa-miR-6822-5p and miR-6824-5p is hs a-miR-6824-5p and miR-6826-5p are hsa-miR-682 6-5p, miR-6850-5p is hsa-miR-6850-5p, m iR-6858-5p is hsa-miR-6858-5p and miR-6861-5 p is hsa-miR-6861-5p and miR-6880-3p is hsa-miR -6880-3p and miR-7107-5p was hsa-miR-7107-5p miR-7109-5p is hsa-miR-7109-5p, and miR-71 14-5p is hsa-miR-7114-5p and miR-7704 is hsa-mi R-7704, and miR-7846-3p is hsa-miR-7846-3p , miR-8052 is hsa-miR-8052 and miR-8060 is hsa-m iR-8060, miR-8071 is hsa-miR-8071, and miR- 8073 is hsa-miR-8073, and miR-874-5p is hsa-miR- 874-5p, miR-204-3p is hsa-miR-204-3p, m iR-3154 is hsa-miR-3154 and miR-3960 is hsa-miR -3960, and miR-4433a-5p is hsa-miR-4433a-5p. miR-4455 is hsa-miR-4455 and miR-4462 is hsa- miR-4462 and miR-4476 are hsa-miR-4476 and miR -4508 is hsa-miR-4508 and miR-4687-3p is hsa-mi miR-4687-3p and miR-4687-5p are hsa-miR-4687-5p and miR-4732-5p is hsa-miR-4732-5p and miR-4 771 is hsa-miR-4771, and miR-642a-3p is hsa-miR- 642a-3p, and miR-6732-5p is hsa-miR-6732-5p. miR-6760-5p is hsa-miR-6760-5p, and miR-679 9-5p is hsa-miR-6799-5p and miR-6820-5p is hsa- miR-6820-5p and miR-6821-5p are hsa-miR-6821- 5p, miR-6829-5p is hsa-miR-6829-5p, and miR -6893-5p is hsa-miR-6893-5p and miR-7108-3p is hsa-miR-7108-3p and miR-7111-5p are hsa-miR-7 111-5p, miR-8089 is hsa-miR-8089, and miR-8 85-3p is hsa-miR-885-3p and miR-92b-3p is hsa-m iR-92b-3p and miR-1343-3p are hsa-miR-1343-3p and miR-6746-5p is hsa-miR-6746-5p and miR-4 22a is hsa-miR-422a, and miR-187-5p is hsa-miR-1 87-5p, and miR-4632-5p is hsa-miR-4632-5p; miR-6791-5p is hsa-miR-6791-5p, and miR-103a- 3p is hsa-miR-103a-3p, and miR-107 is hsa-miR-10 7, miR-1199-5p is hsa-miR-1199-5p, and miR- 1225-3p is hsa-miR-1225-3p and miR-1225-5p is hsa sa-miR-1225-5p and miR-1228-5p are hsa-miR-12 28-5p, and miR-1229-5p is hsa-miR-1229-5p; miR-1233-5p is hsa-miR-1233-5p, and miR-1237- 5p is hsa-miR-1237-5p and miR-1247-3p is hsa-mi miR-1247-3p and miR-1249-3p are hsa-miR-1249-3p and miR-1254 is hsa-miR-1254 and miR-1260b is hsa-miR-1254. sa-miR-1260b and miR-1268a in hsa-miR-1268a miR-1268b is hsa-miR-1268b, and miR-1273g- 3p is hsa-miR-1273g-3p, and miR-128-1-5p is hsa- miR-128-1-5p and miR-128-2-5p are hsa-miR-128 -2-5p, miR-1290 is hsa-miR-1290, and miR-15 0-3p is hsa-miR-150-3p and miR-17-3p is hsa-miR -17-3p, and miR-1908-5p is hsa-miR-1908-5p , miR-1909-3p is hsa-miR-1909-3p, and miR-1914 -3p is hsa-miR-1914-3p and miR-1915-3p is hsa-m iR-1915-3p and miR-191-5p are hsa-miR-191-5p miR-22-3p is hsa-miR-22-3p and miR-23b-3p is hsa-miR-23b-3p, and miR-24-3p is hsa-miR-24- 3p, miR-296-3p is hsa-miR-296-3p, and miR-2 96-5p is hsa-miR-296-5p and miR-3131 is hsa-miR -3131, and miR-3162-5p is hsa-miR-3162-5p, miR-3188 is hsa-miR-3188 and miR-3196 is hsa-mi miR-3196, miR-3197 is hsa-miR-3197, and miR-3 20a is hsa-miR-320a, and miR-342-5p is hsa-miR-3 42-5p, miR-3621 is hsa-miR-3621, and miR-36 48 is hsa-miR-3648 and miR-3656 is hsa-miR-3656 and miR-365a-5p is hsa-miR-365a-5p and miR-3 665 is hsa-miR-3665, and miR-3679-5p is hsa-miR- 3679-5p, and miR-371a-5p is hsa-miR-371a-5p. miR-3940-5p is hsa-miR-3940-5p, and miR-423 -5p is hsa-miR-423-5p, and miR-4257 is hsa-miR-4 257, miR-4270 is hsa-miR-4270, and miR-4271 is hsa-miR-4271 and miR-4286 is hsa-miR-4286 miR-4298 is hsa-miR-4298 and miR-4417 is hsa- miR-4417, miR-4442 is hsa-miR-4442, and miR -4446-3p is hsa-miR-4446-3p, and miR-4448 is hsa -miR-4448 and miR-4454 is hsa-miR-4454, R-4467 is hsa-miR-4467 and miR-4472 is hsa-miR- 4472, miR-4507 is hsa-miR-4507, and miR-451 6 is hsa-miR-4516 and miR-451a is hsa-miR-451a miR-4649-5p is hsa-miR-4649-5p, and miR-46 51 is hsa-miR-4651 and miR-4665-3p is hsa-miR-4 665-3p, miR-4674 is hsa-miR-4674, and miR-4 675 is hsa-miR-4675 and miR-4689 is hsa-miR-468 9, miR-4695-5p is hsa-miR-4695-5p, and miR- 4697-5p is hsa-miR-4697-5p and miR-4725-3p is hsa sa-miR-4725-3p and miR-4739 is hsa-miR-4739 miR-4745-5p is hsa-miR-4745-5p, and miR-47 63-3p is hsa-miR-4763-3p, and miR-4792 is hsa-mi R-4792, miR-486-3p is hsa-miR-486-3p, iR-5001-5p is hsa-miR-5001-5p and miR-5195-3 p is hsa-miR-5195-3p and miR-550a-5p is hsa-miR -550a-5p, miR-5698 is hsa-miR-5698, and miR -6075 is hsa-miR-6075 and miR-6088 is hsa-miR-6 088, miR-6089 is hsa-miR-6089, and miR-6125 miR-6125 is hsa-miR-6125 and miR-6126 is hsa-miR-6126. miR-614 is hsa-miR-614 and miR-615-5p is hsa- miR-615-5p and miR-619-5p are hsa-miR-619-5p miR-638 is hsa-miR-638 and miR-642b-3p is hs a-miR-642b-3p, and miR-650 is hsa-miR-650; miR-663a is hsa-miR-663a and miR-663b is hsa-mi R-663b, miR-6717-5p is hsa-miR-6717-5p , miR-6721-5p is hsa-miR-6721-5p, and miR-6726 -5p is hsa-miR-6726-5p and miR-6727-5p is hsa-m iR-6727-5p and miR-6738-5p are hsa-miR-6738-5 p, miR-6741-5p is hsa-miR-6741-5p, and miR- 6749-5p is hsa-miR-6749-5p and miR-6752-5p is hsa sa-miR-6752-5p and miR-675-5p are hsa-miR-675 -5p, miR-6757-5p is hsa-miR-6757-5p, R-6763-5p is hsa-miR-6763-5p and miR-6765-5p is hsa-miR-6765-5p, and miR-6775-5p is hsa-miR- 6775-5p and miR-6780b-5p is hsa-miR-6780b-5p and miR-6782-5p is hsa-miR-6782-5p and miR-6 784-5p is hsa-miR-6784-5p and miR-6800-5p is hs a-miR-6800-5p and miR-6806-5p are hsa-miR-680 6-5p, miR-6840-3p is hsa-miR-6840-3p, m iR-6848-5p is hsa-miR-6848-5p and miR-6851-5 p is hsa-miR-6851-5p and miR-6870-5p is hsa-miR -6870-5p and miR-6872-3p is hsa-miR-6872-3p miR-6875-5p is hsa-miR-6875-5p, and miR-68 77-5p is hsa-miR-6877-5p and miR-6879-5p is hsa -miR-6879-5p and miR-6880-5p are hsa-miR-6880 -5p, miR-6885-5p is hsa-miR-6885-5p, R-6887-5p is hsa-miR-6887-5p and miR-7108-5p is hsa-miR-7108-5p and miR-711 is hsa-miR-711 miR-7113-3p is hsa-miR-7113-3p, and miR-74 4-5p is hsa-miR-744-5p, and miR-760 is hsa-miR-7 60, miR-7845-5p is hsa-miR-7845-5p, and miR -7847-3p is hsa-miR-7847-3p, and miR-7977 is hsa -miR-7977 and miR-8059 are hsa-miR-8059, R-8063 is hsa-miR-8063 and miR-8072 is hsa-miR- 8072, miR-874-3p is hsa-miR-874-3p, and miR -92a-2-5p is hsa-miR-92a-2-5p, and miR-92b-5p is hsa-miR-92b-5p and miR-940 is hsa-miR-940 miR-1228-3p is hsa-miR-1228-3p, and miR-127 5 is hsa-miR-1275 and miR-1307-3p is hsa-miR-13 07-3p, and miR-1343-5p is hsa-miR-1343-5p; miR-23a-3p is hsa-miR-23a-3p and miR-29b-3p is hsa-miR-29b-3p and miR-3135b are hsa-miR-3135 b, miR-3185 is hsa-miR-3185, and miR-4532 is h sa-miR-4532 and miR-4690-5p is hsa-miR-4690- 5p, miR-4758-5p is hsa-miR-4758-5p, and miR -4783-3p is hsa-miR-4783-3p, and miR-6131 is hsa -miR-6131, and miR-625-3p is hsa-miR-625-3p. miR-6511a-5p is hsa-miR-6511a-5p, and miR-6 765-3p is hsa-miR-6765-3p and miR-6816-5p is hs a-miR-6816-5p and miR-6825-5p are hsa-miR-682 5-5p, miR-6845-5p is hsa-miR-6845-5p, and m iR-7150 is hsa-miR-7150 and miR-7641 is hsa-miR -7641, miR-7975 is hsa-miR-7975, and miR-92 a-3p is hsa-miR-92a-3p, is a method for detecting lung cancer.

[0044] <Terminology> Terms used herein have the following definitions. The abbreviations for nucleotide, polynucleotide, DNA, RNA, etc. are used in Guidelines for the preparation of specifications, etc., including sequences or amino acid sequences" (edited by the Japan Patent Office) and and convention in the art.

[0045] As used herein, the term "polynucleotide" refers to RNA, DNA, and RNA / DNA ( The term "DNA" refers to nucleic acids that include both cDNA and chimeric DNA. The above-mentioned RNA includes total DNA, genomic DNA, and synthetic DNA. l RNA, mRNA, rRNA, miRNA, siRNA, snoRNA, snRNA In the present specification, the term "RNA" includes both non-coding RNA and synthetic RNA. "Synthetic DNA" and "synthetic RNA" are defined as those that have a specific base sequence (either a natural sequence or a non-natural sequence). ) may be artificially produced using, for example, an automated nucleic acid synthesizer. The term "non-natural sequence" as used herein refers to DNA and RNA. The present invention is intended to include sequences that differ from the native sequence by, for example, one or more nucleotide substitutions, deletions, Sequences containing insertions and / or additions (i.e., mutant sequences), which contain one or more modified nucleotides As used herein, the term "polynucleotide" includes sequences that include the nucleic acid sequence (i.e., modified sequences), and the like. The term nucleic acid is used interchangeably with nucleic acid.

[0046] As used herein, the term "fragment" refers to a fragment having a continuous partial base sequence of a polynucleotide. It is a polynucleotide having 15 or more bases, preferably 17 or more bases, and more preferably 1 It is preferable that the length is 9 bases or more.

[0047] In this specification, the term "gene" refers not only to RNA and double-stranded DNA, but also to any of the components thereof. Each strand of DNA contains a single strand of DNA, such as the positive strand (or sense strand) or the complementary strand (or antisense strand). The term is used with the intention of including all of the above, and is not intended to be limited by its length.

[0048] Therefore, in this specification, unless otherwise specified, the term "gene" includes human genomic DNA. Double-stranded DNA, single-stranded DNA (positive strand), and single-stranded DNA with a sequence complementary to the positive strand (complementary strand), cDNA, microRNA (miRNA), and fragments thereof, human genome The term "gene" includes any of a specific base sequence (or sequences) and its transcription products. Not only are genes (represented by column numbers) encoded by these genes, but also the RNA and living organisms RNAs that are biologically equivalent, e.g., homologs (i.e., homologs or orthologs) The term "nucleic acid" includes "nucleic acids" that encode variants, such as polymorphisms, and derivatives. The "nucleic acid" that encodes the mutant or derivative is specifically the sequence described below. A nucleic acid sequence represented by any one of SEQ ID NOs: 1 to 1000 or the corresponding nucleic acid sequence under irradiated conditions. The base sequence has a base sequence that hybridizes with a complementary sequence of the base sequence in which u is t. "Nucleic acid" refers to a gene that is a part of a cell. It may include, for example, expression control regions, coding regions, exons or introns. In addition, a "gene" may be contained within a cell, or it may be released outside the cell and exist independently. Alternatively, the protein may be encapsulated in a vesicle called an exosome.

[0049] As used herein, "exosome" refers to a lipid-derived substance secreted from a cell. Exosomes are small vesicles enclosed in a plasma bilayer. They originate from multivesicular endosomes and are transported into the extracellular environment. When they are released into the atmosphere, they contain biological materials such as RNA, DNA, and other "genes" and proteins. Exosomes are known to be contained in bodily fluids such as blood, serum, plasma, and lymph. It is being done.

[0050] As used herein, the term "transcription product" refers to a RNA synthesized using the DNA sequence of a gene as a template. A refers to the region called the promoter upstream of the gene. The ribonucleotide is then attached to the 3' end of the DNA so that it is complementary to the base sequence of the DNA. This RNA contains not only the gene itself, but also the A region, coding region, exon or intron, or a region extending from the transcription initiation site to the polyA sequence The entire sequence is included up to the termini.

[0051] In addition, in this specification, unless otherwise specified, "microRNA (miRNA)" means It is transcribed as a hairpin-like RNA precursor and has RNase III cleavage activity. It is cleaved by sRNA cleavage enzyme, incorporated into a protein complex called RISC, and Non-coding RNAs of 15 to 25 bases involved in RNA translational repression are used intentionally. In addition, as used herein, "miRNA" is represented by a specific base sequence (or sequence number). In addition to the miRNAs themselves, we also study the precursors of the miRNAs (pre-miRNAs, p The miRNAs encoded by these and their biological functions are miRNAs that are equivalent, e.g., homologs (i.e., homologs or orthologs), The term "miRNA" also includes "miRNAs" that code for variants, such as polymorphisms, and derivatives. Specifically, the "miRNA" encoding the miRNA, its homologue, variant or derivative is Base release 21(http: / / www.mirbase.org / ) and can be identified by the following sequence numbers: A salt that hybridizes with a complementary sequence of any specific base sequence represented by any one of the following: In addition, the term "miRNA" as used herein may be used interchangeably with "miRNA" having a base sequence. An "miRNA" may be the gene product of a miR gene, and such a gene product may , mature miRNA (e.g., 15-25 nucleotides involved in translational repression of the above-mentioned mRNA) , or 19 to 25 bases, non-coding RNA) or miRNA precursor (e.g., miRNAs include pre-miRNAs or pri-miRNAs such as

[0052] As used herein, the term "probe" refers to an RNA generated by gene expression or a probe derived therefrom. Polynucleotides and / or nucleic acids used to specifically detect the polynucleotides includes polynucleotides complementary thereto.

[0053] As used herein, a "primer" refers to an RNA generated by gene expression or a primer therefor. A continuous polynucleotide that specifically recognizes and amplifies the polynucleotide from which it is derived, and and / or a polynucleotide complementary thereto.

[0054] As used herein, the term "complementary polynucleotide" or "polynucleotide having a complementary base sequence" refers to a "Nucleotide" (complementary strand, reverse strand) refers to the base sequence of the target polynucleotide or The full length sequence of the base sequence in which u is t, or a partial sequence thereof (where For convenience, these base sequences are called the positive strand), whereas base sequences such as A:T(U) and G:C Based on the pairing relationship, it means a polynucleotide that is in a base-complementary relationship. A complementary polynucleotide is a polynucleotide that forms a completely complementary sequence with the base sequence of the target positive strand. However, the present invention is not limited to the above, and any other suitable hybridization target may be used. They may have a complementary relationship.

[0055] As used herein, "stringent conditions" refers to conditions under which a nucleic acid probe is capable of binding to other sequences. to a detectably greater extent (e.g., the average of background measurements + background The number of hybridizations that hybridize to the target sequence is 2 times the standard error of the round measurement. Stringent conditions are sequence-dependent and are conditions under which hybridization is Depends on the environment in which it is performed. Stringency of hybridization and / or washing conditions By controlling the frequency, it is possible to obtain a target sequence that is 100% complementary to the nucleic acid probe. Specific examples of "stringent conditions" are described below.

[0056] As used herein, the term "Tm value" refers to the temperature at which the double-stranded portion of a polynucleotide is denatured into a single strand. means the temperature at which double-stranded and single-stranded forms exist in a 1:1 ratio.

[0057] As used herein, the term "mutant" refers to a naturally occurring variant of a nucleic acid resulting from polymorphism, mutation, etc. or a variant thereof, or a base sequence represented by a sequence number or a base sequence in which u is t In a certain base sequence or a partial sequence thereof, one, two, three or more (e.g., one to several ) or any of SEQ ID NOs: 1 to 329. The base sequence of the precursor RNA (premature miRNA) of the sequence or the corresponding In the base sequence, u is t, or in a partial sequence thereof, one or more bases Mutations containing deletions, substitutions, additions or insertions, or each of said base sequences or subsequences thereof 90% or more, about 95% or more, about 97% or more, about 98% or more, about 99% or more percent identity with or a polynucleotide or oligonucleotide containing said base sequence or a partial sequence thereof. The term "hybridizable nucleic acid" refers to a nucleic acid that hybridizes to a nucleic acid under stringent conditions as defined above. do.

[0058] As used herein, "several" refers to an integer between about 10, 9, 8, 7, 6, 5, 4, 3, or 2. means.

[0059] In the present specification, the term "mutant" refers to a mutation produced by site-directed mutagenesis or PCR. They can be produced using well-known techniques such as heterotransferase.

[0060] As used herein, "% identity" is calculated using the BLAST (https: / / blast.ncb i.nlm.nih.gov / Blast.cgi) or FASTA (http: / / www Protein or gene detection using the fasta (w.genome.jp / tools / fasta / ) Using a search system to determine whether or not a gap is introduced (Zheng Zhang et al., 2000, J. Comput. Biol. , vol. 7, pp. 203-214; Altschul, S. F. et al., 1990, Journa of Molecular Biology, Vol. 215, p403-410; arson, W. R. et al., 1988, Proc. Natl. Acad. Sci. USA, Vol. 85, p2444-2448).

[0061] As used herein, the term "derivative" refers to a modified nucleic acid, including, but not limited to, labeling with a fluorophore or the like. modified nucleotides (e.g., halogenated, alkyl, methoxy, etc.); Reconstruction of nucleotides and bases containing alkoxy, thio, carboxymethyl, etc. groups , nucleotides that have undergone double bond saturation, deamination, and replacement of oxygen molecules with sulfur molecules. PNA (peptide nucleic acid; Niel Sen, P.E. et al., 1991, Science, Vol. 254, p1497-500) LNA (locked nucleic acid; Obika, S. et al., 1998) , Tetrahedron Lett., Vol. 39, p5401-5404) This means:

[0062] As used herein, a polynucleotide selected from the miRNAs that are lung cancer markers is provided. or a polynucleotide having a base sequence complementary to said polynucleotide. The "nucleic acid" capable of binding is a synthetic or prepared nucleic acid, e.g., The term "nucleic acid probe" or "primer" includes a nucleic acid that can be detected. To detect the presence or absence of lung cancer in a subject, or to determine the presence or absence, severity, or severity of lung cancer. In order to diagnose whether or not lung cancer has improved, the degree of improvement, and the sensitivity of lung cancer to treatment, or to screen for candidate substances useful for the prevention, amelioration or treatment of lung cancer. These include indirect use of serotonin in the body, particularly in blood and urine, in relation to lung cancer. A transcript represented by any one of SEQ ID NOs: 1 to 1000 or its cDNA in a sample such as a liquid A. Nucleotides, oligonucleotides and nucleotides capable of specifically recognizing and binding to synthetic nucleic acids These nucleotides, oligonucleotides and polynucleotides are included. Based on the above properties, the nucleotides are used to detect the above genes expressed in vivo, in tissues, or within cells. It is used as a probe to detect the above genes and as a primer to amplify the above genes expressed in vivo. It can be effectively used as a marker.

[0063] The term "detection" as used herein means inspection, measurement, detection, or judgment support. In addition, the term "evaluation" as used herein means a test result or a measurement result. The term "diagnosis" is used to include assisting in diagnosis or evaluation based on the above.

[0064] As used herein, a "subject" refers to a human, a primate, including a chimpanzee, a dog, a cat, or the like. Any pet animal, livestock animals such as cows, horses, sheep, goats, rodents such as mice and rats The preferred subject is a human. In the present specification, the term "subject" may be sometimes referred to as "test subject." Also, such a mammal may be an animal that is not affected by the cancer to be detected. The term "subject" refers to a subject. A preferred healthy subject is a human.

[0065] As used herein, "lung cancer" refers to a malignant tumor that occurs in the lungs, and includes small cell lung cancer and non-small cell lung cancer. It is broadly classified into small cell lung cancer and non-small cell lung cancer. Examples include lung adenocarcinoma, squamous cell lung carcinoma, and large cell lung carcinoma.

[0066] As used herein, "pulmonary adenocarcinoma" or "adenocarcinoma" refers to any cancer that has ductal differentiation or mucus production. This is lung cancer that is considered survivable.

[0067] As used herein, "lung squamous cell carcinoma" or "squamous cell carcinoma" refers to keratinized or cytoplasmic squamous cell carcinoma. This is lung cancer showing interalveolar bridges.

[0068] As used herein, "large cell lung cancer" or "large cell carcinoma" refers to an undifferentiated malignant epithelial tumor. Lung cancer that does not fall into the category of small cell carcinoma, adenocarcinoma, or squamous cell carcinoma.

[0069] As used herein, "small cell lung cancer" or "small cell carcinoma" refers to a type of cancer that is made up of small cells. Lung cancer. The tumor cells are round, oval, or spindle-shaped, with scant cytoplasm. The cell boundaries are unclear.

[0070] As used herein, "other lung cancer" refers to adenocarcinoma, squamous cell carcinoma, large cell carcinoma, small cell carcinoma, and Lung cancer other than alveolar carcinoma, e.g., carcinoid tumor, adenosquamous carcinoma, pleomorphic carcinoma , salivary gland cancer, etc.

[0071] As used herein, "P" or "P value" refers to the probability that a statistical test will This indicates the probability that a more extreme statistic than the one calculated from the actual data will be observed. Therefore, the smaller the "P" or "P value," the more significant the difference between the compared subjects is considered to be.

[0072] As used herein, "sensitivity" refers to the value of (number of true positives) / (number of true positives + number of false negatives). High sensitivity means that it is possible to detect lung cancer early and completely cut off the cancer. This leads to removal of the tumor and reduced recurrence rates.

[0073] As used herein, "specificity" means (number of true negatives) / (number of true negatives + number of false positives). High specificity would prevent unnecessary additional testing due to misclassification of healthy individuals as lung cancer patients. This will prevent the practice from being carried out, reducing the burden on patients and cutting medical costs.

[0074] In this specification, "accuracy" means the value of (number of true positives + number of true negatives) / (total number of cases). Accuracy indicates the percentage of all samples for which the discrimination results were correct, and is used to evaluate detection performance. This will be the first indicator.

[0075] In this specification, the term "specimen" to be determined, detected or diagnosed refers to a specimen that is capable of detecting the occurrence of lung cancer, The expression of the gene of the present invention changes with the progression of lung cancer and with the effect of treatment against lung cancer. This refers to tissues and biomaterials, specifically lung tissue, lymph nodes and surrounding organs, and tissues suspected of metastasis. Organs, skin, and body fluids such as blood, urine, saliva, sweat, and tissue exudates, and blood samples This refers to serum, plasma, and other samples such as feces and hair. Furthermore, biological samples extracted from these include Specifically, it refers to genes such as RNA and miRNA.

[0076] As used herein, the term "hsa-miR-6787-5p gene" or "hsa-mi The term "miR-6787-5p" refers to hsa-miR-6787-5p as set forth in SEQ ID NO:1. p gene (miRBase Accession No. MIMAT0027474) Other species homologs or orthologs are also included. hsa-miR-6787 -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described in p. 1634-1645. iR-6787-5p is a precursor of the hairpin-like structure known as hsa-mir- 6787" (miRBase Accession No. MI0022632, sequence no. No. 330) is known.

[0077] As used herein, "hsa-miR-920 gene" or "hsa-miR-92 The term "miR-920" refers to the hsa-miR-920 gene set forth in SEQ ID NO: 2 (miRBase Accession No. MIMAT0004970) and other species homologs The hsa-miR-920 gene is GW et al., 2007, Int J Androl, vol. 30, p316-326 In addition, "hsa-miR-920" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-920) has a hairpin-like structure. ion No. MI0005712, sequence number 331) is known.

[0078] As used herein, "hsa-miR-3622a-5p gene" or "hsa-m The term "hsa-miR-3622a-5p" refers to hsa-miR-3622 as set forth in SEQ ID NO: 3. a-5p gene (miRBase Accession No. MIMAT001800 3) and other species homologs or orthologs. The 622a-5p gene is described in Witten D et al., 2010, BMC Biol, Vol. 8, The miR-3622 can be obtained by the method described in p. a-5p" has a hairpin-like structure as its precursor "hsa-mir-3622a" (miRBase Accession No. MI0016013, SEQ ID NO: 332) It is known that.

[0079] As used herein, "hsa-miR-1185-1-3p gene" or "hsa- The term "miR-1185-1-3p" refers to hsa-miR-1185-1-3p as set forth in SEQ ID NO: 4. 85-1-3p gene (miRBase Accession No. MIMAT002 2838) and other species homologs or orthologs. The R-1185-1-3p gene was identified in Berezikov E et al., 2006, Genom e Res, Vol. 16, p. 1289-1298. In addition, "hsa-miR-1185-1-3p" has a hairpin-like structure as its precursor. The miRBase Accession No. .MI0003844, sequence number 333) is known.

[0080] As used herein, "hsa-miR-4327 gene" or "hsa-miR-4 The term "miR-4327" refers to the hsa-miR-4327 gene (miRB-4327) set forth in SEQ ID NO:5. ase Accession No. MIMAT0016889) and other species homologues The hsa-miR-4327 gene is a member of the Goff By the method described in LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4327" can be obtained by integrating a hairpin "hsa-mir-4327" (miRBase Accession No. o.MI0015867, sequence number 334) is known.

[0081] As used herein, the term "hsa-miR-5739 gene" or "hsa-miR-5 The term "miR-5739" refers to the hsa-miR-5739 gene (miRB) set forth in SEQ ID NO:6. ase Accession No. MIMAT0023116) and other species homologues The hsa-miR-5739 gene is a member of the Yoo JK et al., 2011, Biochem Biophys Res Commun., 4 It can be obtained by the method described in Vol. 15, p. 258-262. -miR-5739 has a hairpin-like structure as its precursor, hsa-mir-5 739" (miRBase Accession No. MI0019412, SEQ ID NO: 335) is known.

[0082] As used herein, "hsa-miR-937-5p gene" or "hsa-miR The term "miR-937-5p" refers to the hsa-miR-937-5p gene set forth in SEQ ID NO: 7. miRBase Accession No. MIMAT0022938 and others Species homologs or orthologs are included. The gene is described in Lui WO et al., 2007, Cancer Res, vol. 67, p6031-6. The miR-937-Hsa gene can be obtained by the method described in US Pat. "miR5p" has a hairpin-like structure as its precursor "hsa-mir-937" (miR Base Accession No. MI0005759, SEQ ID NO: 336) is known. is.

[0083] As used herein, "hsa-miR-1181 gene" or "hsa-miR-1 The term "miR-1181" refers to the hsa-miR-1181 gene (miRB181) set forth in SEQ ID NO: 8. ase Accession No. MIMAT0005826) and other species homologues The hsa-miR-1181 gene is a member of the Subr amanian S et al., 2008, Oncogene, vol. 27, p2015-2026 In addition, "hsa-miR-1181" can be obtained by the method described in Its precursor, "hsa-mir-1181" (miRBase Accession No. MI0006274, SEQ ID NO: 337) is known.

[0084] As used herein, "hsa-miR-1185-2-3p gene" or "hsa- The term "miR-1185-2-3p" refers to hsa-miR-1185-2-3p as set forth in SEQ ID NO: 9. 85-2-3p gene (miRBase Accession No. MIMAT002 2713) and other species homologs or orthologs. The R-1185-2-3p gene was identified in Berezikov E et al., 2006, Genom e Res, Vol. 16, p. 1289-1298. In addition, "hsa-miR-1185-2-3p" has a hairpin-like structure as its precursor. The miRBase Accession No. .MI0003821, sequence number 338) is known.

[0085] As used herein, "hsa-miR-1193 gene" or "hsa-miR-1 The term "miR-1193" refers to the hsa-miR-1193 gene (miR Base Accession No. MIMAT0015049) and other species The hsa-miR-1193 gene is a member of the Sta rk MS et al., 2010, PLoS One, vol. 5, e9685. In addition, "hsa-miR-1193" can be obtained by The pin-like structure of "hsa-mir-1193" (miRBase Accession No. MI0014205, sequence number 339) are known.

[0086] As used herein, the term "hsa-miR-1207-5p gene" or "hsa-mi The term "hsa-miR-1207-5p" refers to hsa-miR-1207- 5p gene (miRBase Accession No. MIMAT0005871) and other species homologs or orthologs. The 7-5p gene is described in Huppi K et al., 2008, Mol Cancer Res, 6 The HSA-M iR-1207-5p is a precursor of the hairpin-like structure known as hsa-mir- 1207" (miRBase Accession No. MI0006340, sequence no. No. 340) is known.

[0087] As used herein, the term "hsa-miR-1238-5p gene" or "hsa-mi The term "hsa-miR-1238-5p" refers to hsa-miR-1238- 5p gene (miRBase Accession No. MIMAT0022947) and other species homologs or orthologs. The 8-5p gene is described in Berezikov E et al., 2007, Mol Cell, vol. 28. The hsa-mi can be obtained by the method described in the above. R-1238-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 238" (miRBase Accession No. MI0006328, SEQ ID NO: 341) is known.

[0088] As used herein, "hsa-miR-1246 gene" or "hsa-miR-1 The term "miR-1246" refers to the hsa-miR-1246 gene (miR Base Accession No. MIMAT0005898) and other species The hsa-miR-1246 gene is a member of the Morphogenetic Algorithm (MAL) family of genes. in RD et al., 2008, Genome Res, vol. 18, p610-621 In addition, "hsa-miR-1246" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-1246) has a hairpin-like structure as a target gene. Session No. MI0006381, sequence number 342) is known.

[0089] As used herein, the term "hsa-miR-1249-5p gene" or "hsa-mi The term "miR-1249-5p" refers to hsa-miR-1249- 5p gene (miRBase Accession No. MIMAT0032029) and other species homologs or orthologs. The 9-5p gene is described in Morin RD et al., 2008, Genome Res, vol. 18, The hsa-miR -1249-5p is a precursor of hsa-mir-12, which has a hairpin-like structure. 49" (miRBase Accession No. MI0006384, SEQ ID NO: 3 43) is known.

[0090] As used herein, the term "hsa-miR-1292-3p gene" or "hsa-mi The term "hsa-miR-1292-3p" refers to hsa-miR-1292- 3p gene (miRBase Accession No. MIMAT0022948) and other species homologs or orthologs. The 2-3p gene is described in Morin RD et al., 2008, Genome Res, vol. 18, The hsa-miR -1292-3p is a precursor of hsa-mir-12, which has a hairpin-like structure. 92" (miRBase Accession No. MI0006433, SEQ ID NO: 3 44) is known.

[0091] As used herein, "hsa-miR-1469 gene" or "hsa-miR-1 The term "miR-1469" refers to the hsa-miR-1469 gene (miR Base Accession No. MIMAT0007347) and other species The hsa-miR-1469 gene is a member of the Kaw The method described in Aji H et al., 2008, BMC Genomics, Vol. 9, p. 157 The precursor of "hsa-miR-1469" is The hairpin-like structure of “hsa-mir-1469” (miRBase Accession No. ion No. MI0007074, sequence number 345) is known.

[0092] As used herein, "hsa-miR-1470 gene" or "hsa-miR-1 The term "miR-1470" refers to the hsa-miR-1470 gene (miR Base Accession No. MIMAT0007348) and other species The hsa-miR-1470 gene is a member of the Kaw The method described in Aji H et al., 2008, BMC Genomics, Vol. 9, p. 157 The precursor of hsa-miR-1470 is The hairpin-like structure of “hsa-mir-1470” (miRBase Accession No. ion No. MI0007075, sequence number 346) is known.

[0093] As used herein, "hsa-miR-197-5p gene" or "hsa-miR The term "miR-197-5p" refers to the hsa-miR-197-5p gene set forth in SEQ ID NO: 18. miRBase Accession No. MIMAT0022691 and its Other species homologs or orthologs are also included. hsa-miR-197-5p The gene is 'Lagos-Quintana M et al., 2003, RNA, vol. 9, p17 The hsa-miR-1 can be obtained by the method described in 97-5p" has a hairpin-like structure as its precursor "hsa-mir-197" ( miRBase Accession No. MI0000239, SEQ ID NO: 347) It is known.

[0094] As used herein, the term "hsa-miR-208a-5p gene" or "hsa-mi The term "hsa-miR-208a-5p" refers to hsa-miR-208a- 5p gene (miRBase Accession No. MIMAT0026474) and other species homologs or orthologs. The a-5p gene is described in Lagos-Quintana M et al., 2003, RNA, vol. 9, The hsa-miR -208a-5p is a precursor of hsa-mir-20, which has a hairpin-like structure. 8a" (miRBase Accession No. MI0000251, SEQ ID NO: 3 48) is known.

[0095] As used herein, "hsa-miR-2110 gene" or "hsa-miR-2 The term "miR-2110" refers to the hsa-miR-2110 gene (miR Base Accession No. MIMAT0010133) and other species The hsa-miR-2110 gene is also known as Zhu JY et al., 2009, J Virol, Vol. 83, p3333-3341 The precursor of hsa-miR-2110 is The hairpin-like structure of “hsa-mir-2110” (miRBase Accession No. ion No. MI0010629, sequence number 349) is known.

[0096] As used herein, "hsa-miR-211-3p gene" or "hsa-miR The term "miR-211-3p" refers to the hsa-miR-211-3p gene set forth in SEQ ID NO: 21. miRBase Accession No. MIMAT0022694 and its Other species homologs or orthologs are also included. hsa-miR-211-3p The gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. In addition, "hsa-miR-211-3p" can be obtained by the method described above. The precursor of the hairpin-like structure "hsa-mir-211" (miRBase A Accession No. MI0000287, SEQ ID NO: 350) is known.

[0097] As used herein, the term "hsa-miR-2467-3p gene" or "hsa-mi The term "hsa-miR-2467-3p" refers to hsa-miR-2467- 3p gene (miRBase Accession No. MIMAT0019953) and other species homologs or orthologs. The 7-3p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 2467-3p is a precursor of hsa-mir-246, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017432, SEQ ID NO: 35 1) is known.

[0098] As used herein, "hsa-miR-3122 gene" or "hsa-miR-3 The term "miR-3122" refers to the hsa-miR-3122 gene (miR Base Accession No. MIMAT0014984) and other species The hsa-miR-3122 gene is a member of the Sta The method described in rk MS et al., 2010, PLoS One., vol. 5, e9685 In addition, "hsa-miR-3122" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-3122" (miRBase Accession No. on No. MI0014138, SEQ ID NO: 352) is known.

[0099] As used herein, "hsa-miR-3141 gene" or "hsa-miR-3 The term "miR-3141" refers to the hsa-miR-3141 gene (miR Base Accession No. MIMAT0015010) and other species The hsa-miR-3141 gene is a member of the Sta rk MS et al., 2010, PLoS One, vol. 5, e9685. In addition, "hsa-miR-3141" can be obtained by The pin-like structure of "hsa-mir-3141" (miRBase Accession No. MI0014165, sequence number 353) are known.

[0100] As used herein, the term "hsa-miR-3156-5p gene" or "hsa-mi The term "hsa-miR-3156-5p" refers to hsa-miR-3156- 5p gene (miRBase Accession No. MIMAT0015030) and other species homologs or orthologs. The 6-5p gene is described in Stark MS et al., 2010, PLoS One., Vol. 5, e The hsa-miR-315 can be obtained by the method described in 9685. 6-5p has a hairpin-like structure as its precursor, hsa-mir-3156-1 , hsa-mir-3156-2, hsa-mir-3156-3” (miRBase Accession No. MI0014184, MI0014230, MI00142 42, SEQ ID NOs: 354, 355, and 356) are known.

[0101] As used herein, the term "hsa-miR-3158-5p gene" or "hsa-mi The term "hsa-miR-3158-5p" refers to hsa-miR-3158- 5p gene (miRBase Accession No. MIMAT0019211) and other species homologs or orthologs. The 8-5p gene is Creighton CJ et al., 2010, PLoS One, Vol. 5 The hsa-miR-3 can be obtained by the method described in e9637. 158-5p is a precursor of hsa-mir-3158, which has a hairpin-like structure. -1, hsa-mir-3158-2” (miRBase Accession No. MI0014186, MI0014187, sequence numbers 357 and 358) are known.

[0102] As used herein, the term "hsa-miR-3160-5p gene" or "hsa-mi The term "hsa-miR-3160-5p" refers to the hsa-miR-3160- 5p gene (miRBase Accession No. MIMAT0019212) and other species homologs or orthologs. The 0-5p gene is described in Stark MS et al., 2010, PLoS One, vol. 5, e96 The hsa-miR-3160- 5p" has a hairpin-like structure as its precursor "hsa-mir-3160-1, h sa-mir-3160-2” (miRBase Accession No. MI00 14189, MI0014190, sequence numbers 359 and 360) are known.

[0103] As used herein, the term "hsa-miR-3180-3p gene" or "hsa-mi The term "hsa-miR-3180-3p" refers to hsa-miR-3180- 3p gene (miRBase Accession No. MIMAT0015058) and other species homologs or orthologs. The 0-3p gene is Creighton CJ et al., 2010, PLoS One, Vol. 5 The hsa-miR-3 can be obtained by the method described in e9637. 180-3p is a precursor of hsa-mir-3180, which has a hairpin-like structure. -1, hsa-mir-3180-2, hsa-mir-3180-3” (miRBas e Accession No. MI0014214, MI0014215, MI001 4217, SEQ ID NOs: 361, 362, 363) are known.

[0104] As used herein, the term "hsa-miR-3191-3p gene" or "hsa-mi The term "hsa-miR-3191-3p" refers to hsa-miR-3191- 3p gene (miRBase Accession No. MIMAT0015075) and other species homologs or orthologs. The 1-3p genes are described in Stark MS et al., 2010, PLoS One, vol. 5, e96 The miR-3191-hsa gene can be obtained by the method described in 85. 3p" has a hairpin-like structure as its precursor "hsa-mir-3191" (mi RBase Accession No. MI0014236, sequence number 364) is known. It is being done.

[0105] As used herein, the term "hsa-miR-3194-3p gene" or "hsa-mi The term "hsa-miR-3194-3p" refers to hsa-miR-3194- 3p gene (miRBase Accession No. MIMAT0019218) and other species homologs or orthologs. The 4-3p gene is described in Stark MS et al., 2010, PLoS One, vol. 5, e96 The hsa-miR-3194- 3p" has a hairpin-like structure as its precursor "hsa-mir-3194" (mi RBase Accession No. MI0014239, sequence number 365) is known. It is being done.

[0106] As used herein, "hsa-miR-320b gene" or "hsa-miR-3 The term "miR-320b" refers to the hsa-miR-320b gene (miR Base Accession No. MIMAT0005792) and other species The hsa-miR-320b gene is a member of the Berkeley Ezikov E et al., 2006, Genome Res, vol. 16, p1289-129 8. Also, "hsa-miR-320b" can be obtained by the method described in The precursors of these proteins are hairpin-like structures called HSA-mir-320b-1 and HSA-m ir-320b-2” (miRBase Accession No.MI000377 6, MI0003839, SEQ ID NOs: 366, 367) are known.

[0107] As used herein, "hsa-miR-328-5p gene" or "hsa-miR The term "miR-328-5p" refers to the hsa-miR-328-5p gene set forth in SEQ ID NO: 32. miRBase Accession No. MIMAT0026486 and its Other species homologs or orthologues are also included. hsa-miR-328-5p The gene is from Kim J et al., 2004, Proc Natl Acad Sci US A, Vol. 101, p. 360-365. "hsa-miR-328-5p" is a precursor of "hsa -mir-328” (miRBase Accession No. MI0000804 , SEQ ID NO: 368) is known.

[0108] As used herein, "hsa-miR-3610 gene" or "hsa-miR-3 The term "miR-3610" refers to the hsa-miR-3610 gene (miR Base Accession No. MIMAT0017987) and other species The hsa-miR-3610 gene is a member of the Wit Ten D et al., 2010, BMC Biol., vol. 8, p. 58. In addition, "hsa-miR-3610" can be obtained by using hairpin as a precursor. The miRBase Accession No. 100111 gene has a mitochondrial structure similar to that of the hsa-mir-3610 gene. No. MI0016000, sequence number 369) is known.

[0109] As used herein, the term "hsa-miR-3619-3p gene" or "hsa-mi The term "hsa-miR-3619-3p" refers to hsa-miR-3619- 3p gene (miRBase Accession No. MIMAT0019219) and other species homologs or orthologs. The 9-3p gene is described in Witten D et al., 2010, BMC Biol, vol. 8, p. 58. The miR-3619-3p antibody can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-3619" (miRB ase Accession No. MI0016009, SEQ ID NO: 370) is known. There are.

[0110] As used herein, the term "hsa-miR-3620-5p gene" or "hsa-mi The term "hsa-miR-3620-5p" refers to the hsa-miR-3620- 5p gene (miRBase Accession No. MIMAT0022967) and other species homologs or orthologs. The 0-5p gene is described in Witten D et al., 2010, BMC Biol, vol. 8, p. 58. The miR-3620-5p antibody can be obtained by the method described in the above. " has a hairpin-like structure as its precursor "hsa-mir-3620" (miRB ase Accession No. MI0016011, SEQ ID NO: 371) is known. There are.

[0111] As used herein, "hsa-miR-370-3p gene" or "hsa-miR The term "miR-370-3p" refers to the hsa-miR-370-3p gene set forth in SEQ ID NO: 36. gene (miRBase Accession No. MIMAT0000722) and its This includes homologs or orthologs from other species. Genes: Suh MR et al., 2004, Dev Biol., vol. 270, pp. 488-4 The miR-370-3 can be obtained by the method described in p” is a precursor of “hsa-mir-370” (miRBp), which has a hairpin-like structure. ase Accession No. MI0000778, SEQ ID NO: 372) is known. There are.

[0112] As used herein, "hsa-miR-373-5p gene" or "hsa-miR The term "miR-373-5p" refers to the hsa-miR-373-5p gene set forth in SEQ ID NO: 37. gene (miRBase Accession No. MIMAT0000725) and its Other species homologs or orthologues are also included. The gene is from Suh MR et al., 2004, Dev Biol, vol. 270, p488-49. 8. Also, "hsa-miR-373-5p " has a hairpin-like structure as its precursor "hsa-mir-373" (miRBa se Accession No. MI0000781, SEQ ID NO: 373) is known. do.

[0113] As used herein, the term "hsa-miR-3917 gene" or "hsa-miR-3 The term "miR-3917" refers to the hsa-miR-3917 gene (miR Base Accession No. MIMAT0018191) and other species The hsa-miR-3917 gene is a miR-3917 gene that is expressed by Cre. Lighton CJ et al., 2010, PLoS One, vol. 5, e9637 The precursor of hsa-miR-3917 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-3917" (miRBase Access sion No. MI0016423, sequence number 374) is known.

[0114] As used herein, the term "hsa-miR-3937 gene" or "hsa-miR-3 The term "miR-3937" refers to the hsa-miR-3937 gene set forth in SEQ ID NO: 39 (miR Base Accession No. MIMAT0018352) and other species The hsa-miR-3937 gene is a member of the Lia o By the method described in JY et al., 2010, PLoS One, vol. 5, e10563 In addition, "hsa-miR-3937" can be obtained by The pin-like structure of "hsa-mir-3937" (miRBase Accession No. MI0016593, sequence number 375) are known.

[0115] As used herein, "hsa-miR-4259 gene" or "hsa-miR-4 The term "miR-4259" refers to the hsa-miR-4259 gene (miR Base Accession No. MIMAT0016880) and other species The hsa-miR-4259 gene is a member of the Gof f According to the method described in LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4259" can be obtained by using hairpin as a precursor. The miRBase Accession No. 1366666 has a sigma-like structure. No. MI0015858, sequence number 376) are known.

[0116] As used herein, "hsa-miR-4281 gene" or "hsa-miR-4 The term "miR-4281" refers to the hsa-miR-4281 gene (miR Base Accession No. MIMAT0016907) and other species The hsa-miR-4281 gene is a member of the Gof f According to the method described in LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4281" can be obtained by using hairpin as a precursor. The miRBase Accession No. 1366666 has a sigma-like structure. No. MI0015885, sequence number 377) are known.

[0117] As used herein, "hsa-miR-4294 gene" or "hsa-miR-4 The term "miR-4294" refers to the hsa-miR-4294 gene (miR Base Accession No. MIMAT0016849) and other species The hsa-miR-4294 gene is a member of the Gof f According to the method described in LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4294" can be obtained by using hairpin as a precursor. The miRBase Accession No. 10116666 (hsa-mir-4294) has a sigma-like structure. No. MI0015827, sequence number 378) are known.

[0118] As used herein, "hsa-miR-4419b gene" or "hsa-miR- The term "miR-4419b" refers to the hsa-miR-4419b gene set forth in SEQ ID NO: 43 ( miRBase Accession No. MIMAT0019034) and other organisms The hsa-miR-4419b gene includes species homologs or orthologs. , Jima DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4419b" can be obtained by the method described above. The hairpin-like structure of the marker “hsa-mir-4419b” (miRBase A Accession No. MI0016861, SEQ ID NO: 379) is known.

[0119] As used herein, "hsa-miR-4428 gene" or "hsa-miR-4 The term "miR-4428" refers to the hsa-miR-4428 gene set forth in SEQ ID NO: 44 (miR Base Accession No. MIMAT0018943) and other species The hsa-miR-4428 gene is a member of the Jim a DD et al., 2010, Blood., vol. 116, e118-e127 The precursor of hsa-miR-4428 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-4428" (miRBase Access sion No. MI0016767, sequence number 380) is known.

[0120] As used herein, "hsa-miR-4429 gene" or "hsa-miR-4 The term "miR-4429" refers to the hsa-miR-4429 gene (miR Base Accession No. MIMAT0018944) and other species The hsa-miR-4429 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4429" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4429" (miRBase Accession No. on No. MI0016768, SEQ ID NO: 381) is known.

[0121] As used herein, the term "hsa-miR-4433a-3p gene" or "hsa-miR-4433a-3p gene" refers to The term "miR-4433a-3p" refers to hsa-miR-443 3a-3p genes (miRBase Accession No. MIMAT00189 49) and other species homologs or orthologs. The 4433a-3p gene is described in Jima DD et al., 2010, Blood, vol. 116, e The hsa-miR -4433a-3p is a precursor of hsa-mir-4, which has a hairpin-like structure. 433a" (miRBase Accession No. MI0016773, sequence no. No. 382) is known.

[0122] As used herein, "hsa-miR-4447 gene" or "hsa-miR-4 The term "miR-4447" refers to the hsa-miR-4447 gene (miR Base Accession No. MIMAT0018966) and other species The hsa-miR-4447 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4447" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4447" (miRBase Accession No. on No. MI0016790, sequence number 383) is known.

[0123] As used herein, "hsa-miR-4449 gene" or "hsa-miR-4 The term "miR-4449" refers to the hsa-miR-4449 gene (miR Base Accession No. MIMAT0018968) and other species The hsa-miR-4449 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4449" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4449" (miRBase Accession No. on No. MI0016792, sequence number 384) is known.

[0124] As used herein, "hsa-miR-4459 gene" or "hsa-miR-4 The term "miR-4459" refers to the hsa-miR-4459 gene set forth in SEQ ID NO: 49 (miR Base Accession No. MIMAT0018981) and other species The hsa-miR-4459 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4459" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4459" (miRBase Accession No. on No. MI0016805, sequence number 385) is known.

[0125] As used herein, "hsa-miR-4480 gene" or "hsa-miR-4 The term "miR-4480" refers to the hsa-miR-4480 gene (miR Base Accession No. MIMAT0019014) and other species The hsa-miR-4480 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4480" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4480" (miRBase Accession No. on No. MI0016841, sequence number 386) is known.

[0126] As used herein, the term "hsa-miR-4485-5p gene" or "hsa-mi The term "miR-4485-5p" refers to hsa-miR-4485- 5p gene (miRBase Accession No. MIMAT0032116) and other species homologs or orthologs. The 5-5p gene is described in Jima DD et al., 2010, Blood., Vol. 116, e11 8-e127. Also, "hsa-miR-4 485-5p is a precursor of hsa-mir-4485, which has a hairpin-like structure. " (miRBase Accession No. MI0016846, SEQ ID NO: 387 ) is known.

[0127] As used herein, "hsa-miR-4486 gene" or "hsa-miR-4 The term "miR-4486" refers to the hsa-miR-4486 gene (miR Base Accession No. MIMAT0019020) and other species The hsa-miR-4486 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4486" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4486" (miRBase Accession No. on No. MI0016847, SEQ ID NO: 388) is known.

[0128] As used herein, "hsa-miR-4488 gene" or "hsa-miR-4 The term "miR-4488" refers to the hsa-miR-4488 gene (miR Base Accession No. MIMAT0019022) and other species The hsa-miR-4488 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4488" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4488" (miRBase Accession No. on No. MI0016849, sequence number 389) is known.

[0129] As used herein, "hsa-miR-4489 gene" or "hsa-miR-4 The term "miR-4489" refers to the hsa-miR-4489 gene (miR Base Accession No. MIMAT0019023) and other species The hsa-miR-4489 gene is a member of the Jim a DD et al., 2010, Blood., vol. 116, e118-e127 The precursor of hsa-miR-4489 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-4489" (miRBase Access sion No. MI0016850, sequence number 390) is known.

[0130] As used herein, "hsa-miR-4505 gene" or "hsa-miR-4 The term "miR-4505" refers to the hsa-miR-4505 gene (miR Base Accession No. MIMAT0019041) and other species The hsa-miR-4505 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4505" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4505" (miRBase Accession No. on No. MI0016868, SEQ ID NO: 391) is known.

[0131] As used herein, "hsa-miR-4513 gene" or "hsa-miR-4 The term "miR-4513" refers to the hsa-miR-4513 gene (miR Base Accession No. MIMAT0019050) and other species The hsa-miR-4513 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4513" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4513" (miRBase Accession No. on No. MI0016879, SEQ ID NO: 392) is known.

[0132] As used herein, "hsa-miR-4515 gene" or "hsa-miR-4 The term "miR-4515" refers to the hsa-miR-4515 gene (miR Base Accession No. MIMAT0019052) and other species The hsa-miR-4515 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4515" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4515" (miRBase Accession No. on No. MI0016881, sequence number 393) is known.

[0133] As used herein, "hsa-miR-4530 gene" or "hsa-miR-4 The term "miR-4530" refers to the hsa-miR-4530 gene (miR Base Accession No. MIMAT0019069) and other species The hsa-miR-4530 gene is a member of the Jim a Method described in DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-4530" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4530" (miRBase Accession No. on No. MI0016897, sequence number 394) is known.

[0134] As used herein, "hsa-miR-4535 gene" or "hsa-miR-4 The term "miR-4535" refers to the hsa-miR-4535 gene (miR Base Accession No. MIMAT0019075) and other species The hsa-miR-4535 gene is a member of the Jim a DD et al., 2010, Blood., vol. 116, e118-e127 The precursor of hsa-miR-4535 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-4535" (miRBase Access sion No. MI0016903, sequence number 395) is known.

[0135] As used herein, "hsa-miR-4635 gene" or "hsa-miR-4 The term "miR-4635" refers to the hsa-miR-4635 gene (miR Base Accession No. MIMAT0019692) and other species The hsa-miR-4635 gene is a member of the Per sson H et al., 2011, Cancer Res., vol. 71, p78-86 In addition, "hsa-miR-4635" can be obtained by the method described above. The hairpin-like structure of the carrier, hsa-mir-4635 (miRBase Ac Accession No. MI0017262, SEQ ID NO: 396) is known.

[0136] As used herein, the term "hsa-miR-4640-5p gene" or "hsa-mi The term "hsa-miR-4640-5p" refers to hsa-miR-4640- 5p gene (miRBase Accession No. MIMAT0019699) and other species homologs or orthologs. The 0-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4640-5p is a precursor of hsa-mir-464, which has a hairpin-like structure. 0" (miRBase Accession No. MI0017267, SEQ ID NO: 39 7) is known.

[0137] As used herein, the term "hsa-miR-4646-5p gene" or "hsa-mi The term "hsa-miR-4646-5p" refers to hsa-miR-4646- 5p gene (miRBase Accession No. MIMAT0019707) and other species homologs or orthologs. The 6-5p gene is described in Persson H et al., 2011, Cancer Res., 7 It can be obtained by the method described in Vol. 1, p. 78-86. R-4646-5p is a precursor of hsa-mir-4, which has a hairpin-like structure. 646" (miRBase Accession No. MI0017273, SEQ ID NO: 398) is known.

[0138] As used herein, "hsa-miR-4656 gene" or "hsa-miR-4 The term "miR-4656" refers to the hsa-miR-4656 gene (miR Base Accession No. MIMAT0019723) and other species The hsa-miR-4656 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4656" can be obtained by the method described above. "hsa-mir-4656" (miRBase Accession No. 16666) has a hairpin-like structure as a target gene. The sequence of the sequence of the nucleotide sequence of the present invention is known to be 399 (sequence number: MI0017284, sequence number: 399).

[0139] As used herein, "hsa-miR-4663 gene" or "hsa-miR-4 The term "miR-4663" refers to the hsa-miR-4663 gene (miR Base Accession No. MIMAT0019735) and other species The hsa-miR-4663 gene is a member of the Per sson H, et al., 2011, Cancer Research, Vol. 71, p. 78 The miR-4663 can be obtained by the method described in . " has a hairpin-like structure as its precursor "hsa-mir-4663" (miRB ase Accession No. MI0017292, sequence number 400) is known. There are.

[0140] As used herein, the term "hsa-miR-4665-5p gene" or "hsa-mi The term "hsa-miR-4665-5p" refers to hsa-miR-4665- 5p gene (miRBase Accession No. MIMAT0019739) and other species homologs or orthologs. The 5-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4665-5p is a precursor of hsa-mir-466, which has a hairpin-like structure. 5" (miRBase Accession No. MI0017295, SEQ ID NO: 40 1) is known.

[0141] As used herein, "hsa-miR-4706 gene" or "hsa-miR-4 The term "miR-4706" refers to the hsa-miR-4706 gene (miR Base Accession No. MIMAT0019806) and other species The hsa-miR-4706 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4706" can be obtained by the method described above. "hsa-mir-4706" (miRBase Accession No. 16) has a hairpin-like structure as a The sequence of the sequence of the nucleotide sequence of the present invention is known to be 402 (serial number MI0017339, sequence number 402).

[0142] As used herein, the term "hsa-miR-4707-5p gene" or "hsa-mi The term "hsa-miR-4707-5p" refers to hsa-miR-4707- 5p gene (miRBase Accession No. MIMAT0019807) and other species homologs or orthologs. The 7-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4707-5p is a precursor of hsa-mir-470, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017340, SEQ ID NO: 40 3) is known.

[0143] As used herein, the term "hsa-miR-4708-3p gene" or "hsa-mi The term "hsa-miR-4708-3p" refers to hsa-miR-4708- 3p gene (miRBase Accession No. MIMAT0019810) and other species homologs or orthologs. The 8-3p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4708-3p is a precursor of hsa-mir-470, which has a hairpin-like structure. 8" (miRBase Accession No. MI0017341, SEQ ID NO: 40 4) is known.

[0144] As used herein, "hsa-miR-4710 gene" or "hsa-miR-4 The term "miR-4710" refers to the hsa-miR-4710 gene (miR Base Accession No. MIMAT0019815) and other species The hsa-miR-4710 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4710" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4710) has a hairpin-like structure as a The sequence of the sequence of the nucleotide sequence of the present invention is known to be 405 (serial number MI0017344, sequence number 405).

[0145] As used herein, "hsa-miR-4718 gene" or "hsa-miR-4 The term "miR-4718" refers to the hsa-miR-4718 gene (miR Base Accession No. MIMAT0019831) and other species The hsa-miR-4718 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4718" can be obtained by the method described above. "hsa-mir-4718" (miRBase Accession No. 18) has a hairpin-like structure as a The sequence of the sequence of the nucleotide sequence of the present invention is known to be 406 (serial number MI0017353, sequence number 406).

[0146] As used herein, the term "hsa-miR-4722-5p gene" or "hsa-mi The term "miR-4722-5p" refers to hsa-miR-4722- 5p gene (miRBase Accession No. MIMAT0019836) and other species homologs or orthologs. The 2-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4722-5p is a precursor of hsa-mir-472, which has a hairpin-like structure. 2" (miRBase Accession No. MI0017357, SEQ ID NO: 40 7) is known.

[0147] As used herein, the term "hsa-miR-4727-3p gene" or "hsa-mi The term "hsa-miR-4727-3p" refers to hsa-miR-4727- 3p gene (miRBase Accession No. MIMAT0019848) and other species homologs or orthologs. The 7-3p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4727-3p is a precursor of hsa-mir-472, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017364, SEQ ID NO: 40 8) is known.

[0148] As used herein, "hsa-miR-4730 gene" or "hsa-miR-4 The term "miR-4730" refers to the hsa-miR-4730 gene (miR Base Accession No. MIMAT0019852) and other species The hsa-miR-4730 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4730" can be obtained by the method described above. The hairpin-like structure of "hsa-mir-4730" (miRBase Accession No. 1) The sequence of the sequence of the nucleotide sequence of the present invention is known to be 409 (serial number MI0017367, sequence number 409).

[0149] As used herein, "hsa-miR-4734 gene" or "hsa-miR-4 The term "miR-4734" refers to the hsa-miR-4734 gene (miR Base Accession No. MIMAT0019859) and other species The hsa-miR-4734 gene is a member of the Per sson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4734" can be obtained by the method described above. "hsa-mir-4734" (miRBase Accession No. 14266) has a hairpin-like structure as a The sequence of the sequence of the nucleotide sequence of the present invention is known to be 410 (serial number MI0017371, sequence number 410).

[0150] As used herein, the term "hsa-miR-4740-5p gene" or "hsa-mi The term "hsa-miR-4740-5p" refers to hsa-miR-4740- 5p gene (miRBase Accession No. MIMAT0019869) and other species homologs or orthologs. The 0-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4740-5p is a precursor of hsa-mir-474, which has a hairpin-like structure. 0" (miRBase Accession No. MI0017378, SEQ ID NO: 41 1) is known.

[0151] As used herein, the term "hsa-miR-4747-3p gene" or "hsa-mi The term "miR-4747-3p" refers to hsa-miR-4747- 3p gene (miRBase Accession No. MIMAT0019883) and other species homologs or orthologs. The 7-3p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4747-3p is a precursor of hsa-mir-474, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017386, SEQ ID NO: 41 2) is known.

[0152] As used herein, the term "hsa-miR-4749-5p gene" or "hsa-mi The term "miR-4749-5p" refers to hsa-miR-4749- 5p gene (miRBase Accession No. MIMAT0019885) and other species homologs or orthologs. The 9-5p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4749-5p is a precursor of hsa-mir-474, which has a hairpin-like structure. 9" (miRBase Accession No. MI0017388, SEQ ID NO: 41 3) is known.

[0153] As used herein, the term "hsa-miR-4755-3p gene" or "hsa-mi The term "hsa-miR-4755-3p" refers to hsa-miR-4755- 3p gene (miRBase Accession No. MIMAT0019896) and other species homologs or orthologs. The 5-3p gene is described in Persson H, et al., 2011, Cancer Research. It can be obtained by the method described in Vol. 71, pp. 78-86. hsa-miR-4755-3p is a precursor of the hairpin-like structure known as hsa -mir-4755” (miRBase Accession No. MI001739 5, SEQ ID NO:414) is known.

[0154] As used herein, the term "hsa-miR-4763-5p gene" or "hsa-mi The term "hsa-miR-4763-5p" refers to hsa-miR-4763- 5p gene (miRBase Accession No. MIMAT0019912) and other species homologs or orthologs. The 3-5p gene is described in Persson H et al., 2011, Cancer Res., 7 It can be obtained by the method described in Vol. 1, p. 78-86. R-4763-5p is a precursor of hsa-mir-4, which has a hairpin-like structure. 763" (miRBase Accession No. MI0017404, SEQ ID NO: 415) is known.

[0155] As used herein, the term "hsa-miR-4787-3p gene" or "hsa-mi The term "hsa-miR-4787-3p" refers to hsa-miR-4787- 3p gene (miRBase Accession No. MIMAT0019957) and other species homologs or orthologs. The 7-3p gene is described in Persson H et al., 2011, Cancer Res, vol. 71. The hsa-miR- 4787-3p is a precursor of hsa-mir-478, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017434, SEQ ID NO: 41 6) is known.

[0156] As used herein, the term "hsa-miR-5008-5p gene" or "hsa-mi The term "hsa-miR-5008-5p" refers to hsa-miR-5008- 5p gene (miRBase Accession No. MIMAT0021039) and other species homologs or orthologs. The 8-5p gene is Hansen TB et al., 2011, RNA Biol, vol. 8, p. 3 The hsa-miR-5 can be obtained by the method described in 008-5p is a precursor of hsa-mir-5008, which has a hairpin-like structure. " (miRBase Accession No. MI0017876, SEQ ID NO: 417 ) is known.

[0157] As used herein, the term "hsa-miR-5010-5p gene" or "hsa-mi The term "hsa-miR-5010-5p" refers to hsa-miR-5010- 5p gene (miRBase Accession No. MIMAT0021043) and other species homologs or orthologs. The 0-5p genes are described in Hansen TB et al., 2011, RNA Biol, Vol. 8, p. 3. The hsa-miR-5 can be obtained by the method described in 010-5p is a precursor of hsa-mir-5010, which has a hairpin-like structure. " (miRBase Accession No. MI0017878, SEQ ID NO: 418 ) is known.

[0158] As used herein, "hsa-miR-504-3p gene" or "hsa-miR The term "miR-504-3p" refers to the hsa-miR-504-3p gene set forth in SEQ ID NO: 83. miRBase Accession No. MIMAT0026612 and its Other species homologs or orthologs are also included. hsa-miR-504-3p The gene is Bentwich I et al., 2005, Nat Genet, vol. 37, p76 The hsa-miR-50 can be obtained by the method described in US Pat. The precursor of 4-3p is the hairpin-like structure hsa-mir-504 (m iRBase Accession No. MI0003189, sequence number 419) is known. It is being done.

[0159] As used herein, "hsa-miR-5090 gene" or "hsa-miR-5 The term "miR-5090" refers to the hsa-miR-5090 gene (miR Base Accession No. MIMAT0021082) and other species The hsa-miR-5090 gene is a member of the Din g N et al., 2011, J Radiat Res, vol. 52, p. 425-432 In addition, "hsa-miR-5090" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-5090) has a hairpin-like structure as a target gene. Session No. MI0017979, sequence number 420) is known.

[0160] As used herein, "hsa-miR-5100 gene" or "hsa-miR-5 The term "miR-5100" refers to the hsa-miR-5100 gene (miR Base Accession No. MIMAT0022259) and other species The hsa-miR-5100 gene is a member of the Tan Don M et al., 2012, Oral Dis, vol. 18, p127-131 The precursor of hsa-miR-5100 can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-5100) sion No. MI0019116, sequence number 421) is known.

[0161] As used herein, the term "hsa-miR-5196-5p gene" or "hsa-mi The term "hsa-miR-5196-5p" refers to hsa-miR-5196- 5p gene (miRBase Accession No. MIMAT0021128) and other species homologs or orthologs. The 6-5p gene is described in Schotte D et al., 2011, Leukemia, vol. 25, p. The method can be obtained by the method described in 1389-1399. R-5196-5p is a precursor of hsa-mir-5, which has a hairpin-like structure. 196" (miRBase Accession No. MI0018175, SEQ ID NO: 422) is known.

[0162] As used herein, the term "hsa-miR-551b-5p gene" or "hsa-mi The term "hsa-miR-551b-5p" refers to hsa-miR-551b- 5p gene (miRBase Accession No. MIMAT0004794) and other species homologs or orthologs. The b-5p gene is described in Cummins JM et al., 2006, Proc Natl Aca d Sci USA, Vol. 103, p. 3687-3692. In addition, "hsa-miR-551b-5p" is a precursor of hair follicle The pin-like structure of "hsa-mir-551b" (miRBase Accession No. MI0003575, sequence number 423) is known.

[0163] As used herein, the term "hsa-miR-557 gene" or "hsa-miR-55 The term "miR-557" refers to the hsa-miR-557 gene (miRBas e Accession No. MIMAT0003221) and other species homologs The hsa-miR-557 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 The hsa- miR-557 has a hairpin-like structure as its precursor, hsa-mir-557 " (miRBase Accession No. MI0003563, SEQ ID NO: 424 ) is known.

[0164] As used herein, the term "hsa-miR-5787 gene" or "hsa-miR-5 The term "miR-5787" refers to the hsa-miR-5787 gene (miR Base Accession No. MIMAT0023252) and other species The hsa-miR-5787 gene is a member of the Yoo H et al., 2011, Biochem Biophys Res Commun, 415 The method can be obtained by the method described in Vol. 5, pp. 567-572. iR-5787 has a hairpin-like structure as its precursor, hsa-mir-578 7" (miRBase Accession No. MI0019797, SEQ ID NO: 42 5) is known.

[0165] As used herein, "hsa-miR-6090 gene" or "hsa-miR-6 The term "miR-6090" refers to the hsa-miR-6090 gene (miR Base Accession No. MIMAT0023715) and other species The hsa-miR-6090 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev, vol. 21, p2049-2057 In addition, "hsa-miR-6090" can be obtained by the method described in Its precursor, "hsa-mir-6090" (miRBase Accession No. MI0020367, SEQ ID NO: 426) is known.

[0166] As used herein, "hsa-miR-6124 gene" or "hsa-miR-6 The term "miR-6124" refers to the hsa-miR-6124 gene (miR Base Accession No. MIMAT0024597) and other species The hsa-miR-6124 gene is a member of the Smi th JL et al., 2012, J Virol, Vol. 86, p5278-5287 In addition, "hsa-miR-6124" can be obtained by the method described above. "hsa-mir-6124" (miRBase Accession No. 1) has a hairpin-like structure as a The sequence of the sequence of the nucleotide sequence of the present invention is known to be 427 (serial number MI0021258, sequence number 427).

[0167] As used herein, "hsa-miR-6132 gene" or "hsa-miR-6 The term "miR-6132" refers to the hsa-miR-6132 gene (miR Base Accession No. MIMAT0024616) and other species The hsa-miR-6132 gene is a member of the Dan Nemann M et al., 2012, Genome Biol Evol, vol. 4, p. 552 The miR-613 can be obtained by the method described in ref. miR 2 has a hairpin-like structure as its precursor, hsa-mir-6132 (miR Base Accession No. MI0021277, sequence number 428) is known. is.

[0168] As used herein, the term "hsa-miR-6510-5p gene" or "hsa-mi The term "hsa-miR-6510-5p" refers to the hsa-miR-6510- 5p gene (miRBase Accession No. MIMAT0025476) and other species homologs or orthologs. The 0-5p gene is Joyce CE et al., 2011, Hum Mol Genet, 2 0, p. 4025-4040. a-miR-6510-5p has a hairpin-like structure as its precursor, hsa-m ir-6510” (miRBase Accession No. MI0022222, SEQ ID NO: 429) is known.

[0169] As used herein, the term "hsa-miR-6511b-5p gene" or "hsa-m The term "hsa-miR-6511b-5p" refers to hsa-miR-6511b-5p as set forth in SEQ ID NO: 94. 1b-5p gene (miRBase Accession No. MIMAT00258 47) and other species homologs or orthologs. The 6511b-5p gene is Li Y et al., 2012, Gene, vol. 497, p330- The miR-6511 can be obtained by the method described in 335. The precursor of b-5p is hsa-mir-6511b- 1, hsa-mir-6511b-2” (miRBase Accession No. MI0022552, MI0023431, sequence numbers 430 and 431) are known.

[0170] As used herein, the term "hsa-miR-6515-3p gene" or "hsa-mi The term "hsa-miR-6515-3p" refers to hsa-miR-6515- 3p gene (miRBase Accession No. MIMAT0025487) and other species homologs or orthologs. The 5-3p gene is Joyce CE et al., 2011, Hum Mol Genet, 2 0, p. 4025-4040. a-miR-6515-3p has a hairpin-like structure as its precursor, hsa-m ir-6515” (miRBase Accession No. MI0022227, SEQ ID NO: 432) is known.

[0171] As used herein, "hsa-miR-654-5p gene" or "hsa-miR The term "miR-654-5p" refers to the hsa-miR-654-5p gene set forth in SEQ ID NO: 96. miRBase Accession No. MIMAT0003330 and its Other species homologs or orthologs are also included. hsa-miR-654-5p The gene is from Cummins JM et al., 2006, Proc Natl Acad Sc i The method described in US A, Vol. 103, p3687-3692 can be used. In addition, "hsa-miR-654-5p" has a hairpin-like structure as its precursor. The structure of “hsa-mir-654” (miRBase Accession No. MI0003676, SEQ ID NO: 433) is known.

[0172] As used herein, the term "hsa-miR-658 gene" or "hsa-miR-65 The term "miR-658" refers to the hsa-miR-658 gene (miRBas e Accession No. MIMAT0003336) and other species homologs The hsa-miR-658 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 The hsa- miR-658 has a hairpin-like structure as its precursor, hsa-mir-658 " (miRBase Accession No. MI0003682, SEQ ID NO: 434 ) is known.

[0173] As used herein, "hsa-miR-668-5p gene" or "hsa-miR The term "miR-668-5p" refers to the hsa-miR-668-5p gene set forth in SEQ ID NO: 98. gene (miRBase Accession No. MIMAT0026636) and its Other species homologs or orthologs are also included. hsa-miR-668-5p Genes: Berezikov E et al., 2006, Genome Res., vol. 16 The hsa- miR-668-5p is a precursor of the hairpin-like structure called "hsa-mir- 668" (miRBase Accession No. MI0003761, SEQ ID NO: 435) is known.

[0174] As used herein, the term "hsa-miR-6722-5p gene" or "hsa-mi The term "hsa-miR-6722-5p" refers to hsa-miR-6722- 5p gene (miRBase Accession No. MIMAT0025853) and other species homologs or orthologs. The 2-5p gene is described in Li Y et al., 2012, Gene., vol. 497, p330-33. The miR-6722-5 can be obtained by the method described in p” has a hairpin-like structure as its precursor “hsa-mir-6722” (miR Base Accession No. MI0022557, sequence number 436) is known. is.

[0175] As used herein, the term "hsa-miR-6724-5p gene" or "hsa-mi The term "miR-6724-5p" refers to hsa-miR-6724 as set forth in SEQ ID NO: 100. -5p gene (miRBase Accession No. MIMAT0025856 ) and other species homologs or orthologs. The 24-5p gene is Li Y et al., 2012, Gene, vol. 497, p330-335. The miR-6724-5p antibody can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-6724" (miRB ase Accession No. MI0022559, sequence number 437) is known. There are.

[0176] As used herein, the term "hsa-miR-6729-3p gene" or "hsa-mi The term "miR-6729-3p" refers to hsa-miR-6729 as set forth in SEQ ID NO: 101. -3p gene (miRBase Accession No. MIMAT0027360 ) and other species homologs or orthologs. The 29-3p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6729-3p has a hairpin-like structure as its precursor, hsa-mi r-6729” (miRBase Accession No. MI0022574, Column number 438) is known.

[0177] As used herein, the term "hsa-miR-6737-5p gene" or "hsa-mi The term "miR-6737-5p" refers to hsa-miR-6737 as set forth in SEQ ID NO: 102. -5p gene (miRBase Accession No. MIMAT0027375 ) and other species homologs or orthologs. The 37-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6737-5p has a hairpin-like structure as its precursor, hsa-mi r-6737” (miRBase Accession No. MI0022582, Column number 439) is known.

[0178] As used herein, the term "hsa-miR-6756-5p gene" or "hsa-mi The term "miR-6756-5p" refers to hsa-miR-6756 as set forth in SEQ ID NO: 103. -5p gene (miRBase Accession No. MIMAT0027412 ) and other species homologs or orthologs. The 56-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6756-5p has a hairpin-like structure as its precursor, hsa-mi r-6756” (miRBase Accession No. MI0022601, Column number 440) is known.

[0179] As used herein, the term "hsa-miR-6762-5p gene" or "hsa-mi The term "miR-6762-5p" refers to hsa-miR-6762 as set forth in SEQ ID NO: 104. -5p gene (miRBase Accession No. MIMAT0027424 ) and other species homologs or orthologs. The 62-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6762-5p has a hairpin-like structure as its precursor, hsa-mi r-6762" (miRBase Accession No. MI0022607, Column number 441) is known.

[0180] As used herein, the term "hsa-miR-6763-3p gene" or "hsa-mi The term "miR-6763-3p" refers to hsa-miR-6763 as set forth in SEQ ID NO: 105. -3p gene (miRBase Accession No. MIMAT0027427 ) and other species homologs or orthologs. The 63-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6763-3p has a hairpin-like structure as its precursor, hsa-mi r-6763” (miRBase Accession No. MI0022608, Column number 442) is known.

[0181] As used herein, the term "hsa-miR-6766-5p gene" or "hsa-mi The term "miR-6766-5p" refers to hsa-miR-6766 as set forth in SEQ ID NO: 106. -5p gene (miRBase Accession No. MIMAT0027432 ) and other species homologs or orthologs. The 66-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6766-5p has a hairpin-like structure as its precursor, hsa-mi r-6766” (miRBase Accession No. MI0022611, Column number 443) is known.

[0182] As used herein, "hsa-miR-6769a-5p gene" or "hsa-m The term "hsa-miR-6769a-5p" refers to hsa-miR-67 69a-5p gene (miRBase Accession No. MIMAT0027 438) and other species homologs or orthologs. The -6769a-5p gene was identified in Ladewig E et al., 2012, Genome Re It can be obtained by the method described in Vol. 22, pp. 1634-1645. "hsa-miR-6769a-5p" is a precursor of "hsa-miR-6769a-5p" which has a hairpin-like structure. sa-mir-6769a” (miRBase Accession No. MI002 2614, SEQ ID NO: 444) is known.

[0183] As used herein, the term "hsa-miR-6771-5p gene" or "hsa-mi The term "miR-6771-5p" refers to hsa-miR-6771 as set forth in SEQ ID NO: 108. -5p gene (miRBase Accession No. MIMAT0027442 ) and other species homologs or orthologs. The 71-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6771-5p has a hairpin-like structure as its precursor, hsa-mi r-6771” (miRBase Accession No. MI0022616, Column number 445) is known.

[0184] As used herein, the term "hsa-miR-6786-5p gene" or "hsa-mi The term "miR-6786-5p" refers to hsa-miR-6786 as set forth in SEQ ID NO: 109. -5p gene (miRBase Accession No. MIMAT0027472 ) and other species homologs or orthologs. The 86-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6786-5p has a hairpin-like structure as its precursor, hsa-mi r-6786" (miRBase Accession No. MI0022631, Column number 446) is known.

[0185] As used herein, the term "hsa-miR-6789-5p gene" or "hsa-mi The term "miR-6789-5p" refers to hsa-miR-6789 as set forth in SEQ ID NO: 110. -5p gene (miRBase Accession No. MIMAT0027478 ) and other species homologs or orthologs. The 89-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, pp. 1634-1645. a-miR-6789-5p has a hairpin-like structure as its precursor, hsa-m ir-6789” (miRBase Accession No. MI0022634, SEQ ID NO: 447) is known.

[0186] As used herein, the term "hsa-miR-6794-5p gene" or "hsa-mi The term "miR-6794-5p" refers to hsa-miR-6794 as set forth in SEQ ID NO: 111. -5p gene (miRBase Accession No. MIMAT0027488 ) and other species homologs or orthologs. The 94-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6794-5p has a hairpin-like structure as its precursor, hsa-mi r-6794" (miRBase Accession No. MI0022639, Column number 448) is known.

[0187] As used herein, the term "hsa-miR-6796-3p gene" or "hsa-mi The term "miR-6796-3p" refers to hsa-miR-6796 as set forth in SEQ ID NO: 112. -3p gene (miRBase Accession No. MIMAT0027493 ) and other species homologs or orthologs. The 96-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6796-3p has a hairpin-like structure as its precursor, hsa-mi r-6796" (miRBase Accession No. MI0022641, Column number 449) is known.

[0188] As used herein, the term "hsa-miR-6797-5p gene" or "hsa-mi The term "miR-6797-5p" refers to hsa-miR-6797 as set forth in SEQ ID NO: 113. -5p gene (miRBase Accession No. MIMAT0027494 ) and other species homologs or orthologs. The 97-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6797-5p has a hairpin-like structure as its precursor, hsa-mi r-6797" (miRBase Accession No. MI0022642, Column number 450) is known.

[0189] As used herein, the term "hsa-miR-6800-3p gene" or "hsa-mi The term "miR-6800-3p" refers to the hsa-miR-6800 -3p gene (miRBase Accession No. MIMAT0027501 ) and other species homologs or orthologs. The 00-3p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6800-3p has a hairpin-like structure as its precursor, hsa-mi r-6800” (miRBase Accession No. MI0022645, Column number 451) is known.

[0190] As used herein, the term "hsa-miR-6802-5p gene" or "hsa-mi The term "miR-6802-5p" refers to hsa-miR-6802 as set forth in SEQ ID NO: 115. -5p gene (miRBase Accession No. MIMAT0027504 ) and other species homologs or orthologs. The 02-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6802-5p has a hairpin-like structure as its precursor, hsa-mi r-6802" (miRBase Accession No. MI0022647, Column number 452) is known.

[0191] As used herein, the term "hsa-miR-6803-5p gene" or "hsa-mi The term "miR-6803-5p" refers to hsa-miR-6803 as set forth in SEQ ID NO: 116. -5p gene (miRBase Accession No. MIMAT0027506 ) and other species homologs or orthologs. The 03-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6803-5p has a hairpin-like structure as its precursor, hsa-mi r-6803” (miRBase Accession No. MI0022648, Column number 453) is known.

[0192] As used herein, the term "hsa-miR-6805-3p gene" or "hsa-mi The term "miR-6805-3p" refers to hsa-miR-6805 as set forth in SEQ ID NO: 117. -3p gene (miRBase Accession No. MIMAT0027511 ) and other species homologs or orthologs. The 05-3p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6805-3p has a hairpin-like structure as its precursor, hsa-mi r-6805” (miRBase Accession No. MI0022650, Column number 454) is known.

[0193] As used herein, the term "hsa-miR-6805-5p gene" or "hsa-mi The term "miR-6805-5p" refers to hsa-miR-6805 as set forth in SEQ ID NO: 118. -5p gene (miRBase Accession No. MIMAT0027510 ) and other species homologs or orthologs. The 05-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6805-5p has a hairpin-like structure as its precursor, hsa-mi r-6805” (miRBase Accession No. MI0022650, Column number 454) is known.

[0194] As used herein, the term "hsa-miR-6807-5p gene" or "hsa-mi The term "miR-6807-5p" refers to hsa-miR-6807 as set forth in SEQ ID NO: 119. -5p gene (miRBase Accession No. MIMAT0027514 ) and other species homologs or orthologs. The 07-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6807-5p has a hairpin-like structure as its precursor, hsa-mi r-6807” (miRBase Accession No. MI0022652, Column number 455) is known.

[0195] As used herein, the term "hsa-miR-6812-5p gene" or "hsa-mi The term "miR-6812-5p" refers to hsa-miR-6812 as set forth in SEQ ID NO: 120. -5p gene (miRBase Accession No. MIMAT0027524 ) and other species homologs or orthologs. The 12-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6812-5p has a hairpin-like structure as its precursor, hsa-mi r-6812" (miRBase Accession No. MI0022657, Column number 456) is known.

[0196] As used herein, the term "hsa-miR-6819-5p gene" or "hsa-mi The term "miR-6819-5p" refers to hsa-miR-6819 as set forth in SEQ ID NO: 121. -5p gene (miRBase Accession No. MIMAT0027538 ) and other species homologs or orthologs. The 19-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6819-5p has a hairpin-like structure as its precursor, hsa-mi r-6819" (miRBase Accession No. MI0022664, Column number 457) is known.

[0197] As used herein, the term "hsa-miR-6822-5p gene" or "hsa-mi The term "miR-6822-5p" refers to hsa-miR-6822 as set forth in SEQ ID NO: 122. -5p gene (miRBase Accession No. MIMAT0027544 ) and other species homologs or orthologs. The 22-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6822-5p has a hairpin-like structure as its precursor, hsa-mi r-6822" (miRBase Accession No. MI0022667, Column number 458) is known.

[0198] As used herein, the term "hsa-miR-6824-5p gene" or "hsa-mi The term "miR-6824-5p" refers to hsa-miR-6824 as set forth in SEQ ID NO: 123. -5p gene (miRBase Accession No. MIMAT0027548 ) and other species homologs or orthologs. The 24-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6824-5p has a hairpin-like structure as its precursor, hsa-mi r-6824" (miRBase Accession No. MI0022669, Column number 459) is known.

[0199] As used herein, the term "hsa-miR-6826-5p gene" or "hsa-mi The term "miR-6826-5p" refers to hsa-miR-6826 as set forth in SEQ ID NO: 124. -5p gene (miRBase Accession No. MIMAT0027552 ) and other species homologs or orthologs. The 26-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6826-5p has a hairpin-like structure as its precursor, hsa-mi r-6826" (miRBase Accession No. MI0022671, Column number 460) is known.

[0200] As used herein, the term "hsa-miR-6850-5p gene" or "hsa-mi The term "miR-6850-5p" refers to the miR-6850 -5p gene (miRBase Accession No. MIMAT0027600 ) and other species homologs or orthologs. The 50-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6850-5p has a hairpin-like structure as its precursor, hsa-mi r-6850" (miRBase Accession No. MI0022696, Column number 461) is known.

[0201] As used herein, the term "hsa-miR-6858-5p gene" or "hsa-mi The term "miR-6858-5p" refers to hsa-miR-6858 as set forth in SEQ ID NO: 126. -5p gene (miRBase Accession No. MIMAT0027616 ) and other species homologs or orthologs. The 58-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6858-5p has a hairpin-like structure as its precursor, hsa-mi r-6858" (miRBase Accession No. MI0022704, Column number 462) is known.

[0202] As used herein, the term "hsa-miR-6861-5p gene" or "hsa-mi The term "miR-6861-5p" refers to hsa-miR-6861 as set forth in SEQ ID NO: 127. -5p gene (miRBase Accession No. MIMAT0027623 ) and other species homologs or orthologs. The 61-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6861-5p has a hairpin-like structure as its precursor, hsa-mi r-6861” (miRBase Accession No. MI0022708, Column number 463) is known.

[0203] As used herein, the term "hsa-miR-6880-3p gene" or "hsa-mi The term "miR-6880-3p" refers to the hsa-miR-6880 -3p gene (miRBase Accession No. MIMAT0027661 ) and other species homologs or orthologs. The 80-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6880-3p has a hairpin-like structure as its precursor, hsa-mi r-6880” (miRBase Accession No. MI0022727, Column number 464) is known.

[0204] As used herein, the term "hsa-miR-7107-5p gene" or "hsa-mi The term "miR-7107-5p" refers to hsa-miR-7107 as set forth in SEQ ID NO: 129. -5p gene (miRBase Accession No. MIMAT0028111 ) and other species homologs or orthologs. The 07-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7107-5p has a hairpin-like structure as its precursor, hsa-mi r-7107" (miRBase Accession No. MI0022958, Column number 465) is known.

[0205] As used herein, the term "hsa-miR-7109-5p gene" or "hsa-mi The term "miR-7109-5p" refers to hsa-miR-7109 as set forth in SEQ ID NO: 130. -5p gene (miRBase Accession No. MIMAT0028115 ) and other species homologs or orthologs. The 09-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7109-5p has a hairpin-like structure as its precursor, hsa-mi r-7109" (miRBase Accession No. MI0022960, Column number 466) is known.

[0206] As used herein, the term "hsa-miR-7114-5p gene" or "hsa-mi The term "miR-7114-5p" refers to hsa-miR-7114 as set forth in SEQ ID NO: 131. -5p gene (miRBase Accession No. MIMAT0028125 ) and other species homologs or orthologs. The 14-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7114-5p has a hairpin-like structure as its precursor, hsa-mi r-7114" (miRBase Accession No. MI0022965, Column number 467) is known.

[0207] As used herein, "hsa-miR-7704 gene" or "hsa-miR-7 The term "miR-7704" refers to the hsa-miR-7704 gene (miR-7704) set forth in SEQ ID NO: 132. RBase Accession No. MIMAT0030019) and other species The hsa-miR-7704 gene is a member of the Sw Aminathan S et al., 2013, Biochem Biophys Res C It can be obtained by the method described in Ommun, vol. 434, pp. 228-234. In addition, "hsa-miR-7704" has a hairpin-like structure as its precursor, "hs a-mir-7704” (miRBase Accession No. MI00252 40, SEQ ID NO: 468) is known.

[0208] As used herein, the term "hsa-miR-7846-3p gene" or "hsa-mi The term "miR-7846-3p" refers to hsa-miR-7846 as set forth in SEQ ID NO: 133. -3p gene (miRBase Accession No. MIMAT0030421 ) and other species homologs or orthologs. The 46-3p gene is Ple H et al., 2012, PLoS One., Vol. 7, e50 The miR-hsa-miR can be obtained by the method described in 746. The precursor of "hsa-mir-7846" (m iRBase Accession No. MI0025516, sequence number 469) is known. It is being done.

[0209] As used herein, "hsa-miR-8052 gene" or "hsa-miR-8 The term "miR-8052" refers to the hsa-miR-8052 gene (miR-8052) set forth in SEQ ID NO: 134. RBase Accession No. MIMAT0030979) and other species The hsa-miR-8052 gene is a member of the Wa The method described in Ng HJ et al., 2013, Shock., vol. 39, pp. 480-487. In addition, "hsa-miR-8052" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-8052" (miRBase Accession No. on No. MI0025888, SEQ ID NO: 470) is known.

[0210] As used herein, "hsa-miR-8060 gene" or "hsa-miR-8 The term "miR-8060" refers to the hsa-miR-8060 gene (miR-8060) set forth in SEQ ID NO: 135. RBase Accession No. MIMAT0030987) and other species The hsa-miR-8060 gene is a member of the Wa The method described in Ng HJ et al., 2013, Shock., vol. 39, pp. 480-487. In addition, "hsa-miR-8060" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-8060" (miRBase Accession No. on No. MI0025896, SEQ ID NO: 471) is known.

[0211] As used herein, "hsa-miR-8071 gene" or "hsa-miR-8 The term "miR-8071" refers to the hsa-miR-8071 gene (miR-8071) set forth in SEQ ID NO: 136. RBase Accession No. MIMAT0030998) and other species The hsa-miR-8071 gene is a member of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8071" can be obtained as a precursor of hsa-miR-8071. "hsa-mir-8071-1, hsa-mir-8071-2" have an apin-like structure (miRBase Accession No. MI0025907, MI002641 7, SEQ ID NOs: 472 and 473) are known.

[0212] As used herein, "hsa-miR-8073 gene" or "hsa-miR-8 The term "miR-8073" refers to the hsa-miR-8073 gene (miR-8073) set forth in SEQ ID NO: 137. RBase Accession No. MIMAT0031000) and other species The hsa-miR-8073 gene is a homologue or ortholog of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8073" can be obtained as a precursor of hsa-miR-8073. The apin-like structure of "hsa-mir-8073" (miRBase Accession n No. MI0025909, sequence number 474) is known.

[0213] As used herein, "hsa-miR-874-5p gene" or "hsa-miR The term "miR-874-5p" refers to hsa-miR-874-5p as set forth in SEQ ID NO: 138. Gene (miRBase Accession No. MIMAT0026718) and Other species homologs or orthologs of hsa-miR-874-5 are also included. p gene, Landgraf P et al., 2007, Cell., vol. 129, p140 The hsa-miR-8 can be obtained by the method described in 74-5p" has a hairpin-like structure as its precursor "hsa-mir-874" ( miRBase Accession No. MI0005532, sequence number 475) It is known.

[0214] As used herein, "hsa-miR-204-3p gene" or "hsa-miR The term "miR-204-3p" refers to the hsa-miR-204-3p set forth in SEQ ID NO: 139. Gene (miRBase Accession No. MIMAT0022693) and Other species homologs or orthologs of hsa-miR-204-3 are also included. The p gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. The hsa-miR-204-3p can be obtained by the method described in Its precursor, "hsa-mir-204" (miRBase Accession No. MI0000284, SEQ ID NO: 476) is known.

[0215] As used herein, "hsa-miR-3154 gene" or "hsa-miR-3 The term "miR-3154" refers to the hsa-miR-3154 gene (miR-3154) set forth in SEQ ID NO: 140. RBase Accession No. MIMAT0015028) and other species The hsa-miR-3154 gene is a homologue or ortholog of the Be Rezikov E et al., 2006, Genome Res, vol. 16, p1289-12 98. Also, "hsa-miR-3154" can be obtained by the method described in The precursor of miRBa has a hairpin-like structure called hsa-mir-3154 (miRBa se Accession No. MI0014182, sequence number 477) is known. do.

[0216] As used herein, the term "hsa-miR-3960 gene" or "hsa-miR-3 The term "miR-3960" refers to the hsa-miR-3960 gene (mi RBase Accession No. MIMAT0019337) and other species The hsa-miR-3960 gene is a member of the Hu R et al., 2011, J Biol Chem, vol. 286, p12328-12339 The hsa-miR-3960 can be obtained by the method described in The precursor of the hairpin-like structure "hsa-mir-3960" (miRBase Accession No. MI0016964, SEQ ID NO: 478) is known.

[0217] As used herein, the term "hsa-miR-4433a-5p gene" or "hsa-m The term "miR-4433a-5p" refers to hsa-miR-44 33a-5p gene (miRBase Accession No. MIMAT0020 956) and other species homologs or orthologs. -4433a-5p gene is Jima DD et al., 2010, Blood, vol. 116, It can be obtained by the method described in E118-E127. R-4433a-5p is a precursor of hsa-mir- 4433a" (miRBase Accession No. MI0016773, sequence Number 382) is known.

[0218] As used herein, "hsa-miR-4455 gene" or "hsa-miR-4 The term "miR-4455" refers to the hsa-miR-4455 gene (miR-4455) set forth in SEQ ID NO: 143. RBase Accession No. MIMAT0018977) and other species The hsa-miR-4455 gene is a homologue or ortholog of the Ji Ma DD et al., 2010, Blood., Vol. 116, e118-e127 In addition, "hsa-miR-4455" can be obtained by the method described above. The hairpin-like structure of the target gene, hsa-mir-4455 (miRBase Accession No. 1511666), The sequence of the sequence of the nucleotide sequence of the present invention is known to be 479 (serial number MI0016801, sequence number 479).

[0219] As used herein, "hsa-miR-4462 gene" or "hsa-miR-4 The term "miR-4462" refers to the hsa-miR-4462 gene set forth in SEQ ID NO: 144 (mi RBase Accession No. MIMAT0018986) and other species The hsa-miR-4462 gene is a homologue or ortholog of the Ji Ma DD et al., 2010, Blood., Vol. 116, e118-e127 In addition, "hsa-miR-4462" can be obtained by the method described above. The hairpin-like structure of "hsa-mir-4462" (miRBase Accession No. 12222) The sequence of the sequence of the nucleotide sequence of the present invention is known to be 480 (serial number MI0016810, sequence number 480).

[0220] As used herein, "hsa-miR-4476 gene" or "hsa-miR-4 The term "miR-4476" refers to the hsa-miR-4476 gene (miR-4476) set forth in SEQ ID NO: 145. RBase Accession No. MIMAT0019003) and other species The hsa-miR-4476 gene is a member of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4476 is The hairpin-like structure of “hsa-mir-4476” (miRBase Accession No. ion No. MI0016828, sequence number 481) is known.

[0221] As used herein, "hsa-miR-4508 gene" or "hsa-miR-4 The term "miR-4508" refers to the hsa-miR-4508 gene (mi RBase Accession No. MIMAT0019045) and other species The hsa-miR-4508 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4508 is The hairpin-like structure of “hsa-mir-4508” (miRBase Accession No. ion No. MI0016872, sequence number 482) is known.

[0222] As used herein, the term "hsa-miR-4687-3p gene" or "hsa-mi The term "miR-4687-3p" refers to hsa-miR-4687 as set forth in SEQ ID NO: 147. -3p gene (miRBase Accession No. MIMAT0019775 ) and other species homologs or orthologs. The 87-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4687-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 87" (miRBase Accession No. MI0017319, SEQ ID NO: 4 83) is known.

[0223] As used herein, the term "hsa-miR-4687-5p gene" or "hsa-mi The term "miR-4687-5p" refers to hsa-miR-4687 as set forth in SEQ ID NO: 148. -5p gene (miRBase Accession No. MIMAT0019774 ) and other species homologs or orthologs. The 87-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4687-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 87" (miRBase Accession No. MI0017319, SEQ ID NO: 4 83) is known.

[0224] As used herein, the term "hsa-miR-4732-5p gene" or "hsa-mi The term "miR-4732-5p" refers to hsa-miR-4732 as set forth in SEQ ID NO: 149. -5p gene (miRBase Accession No. MIMAT0019855 ) and other species homologs or orthologs. The 32-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4732-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 32" (miRBase Accession No. MI0017369, SEQ ID NO: 4 84) is known.

[0225] As used herein, "hsa-miR-4771 gene" or "hsa-miR-4 The term "miR-4771" refers to the hsa-miR-4771 gene (miR-4771) set forth in SEQ ID NO: 150. RBase Accession No. MIMAT0019925) and other species The hsa-miR-4771 gene is a homologue or ortholog of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4771" can be obtained by the method described above. The hairpin-like structures of hsa-mir-4771-1 and hsa-mir-47 71-2” (miRBase Accession No. MI0017412, MI0 017413, SEQ ID NOs: 485, 486) are known.

[0226] As used herein, the term "hsa-miR-642a-3p gene" or "hsa-mi The term "miR-642a-3p" refers to hsa-miR-642a -3p gene (miRBase Accession No. MIMAT0020924 ) and other species homologs or orthologs. The 2a-3p genes are described in Cummins JM et al., 2006, Proc Natl Ac Ad Sci USA, vol. 103, pp. 3687-3692 In addition, "hsa-miR-642a-3p" can be obtained as a precursor of hsa-miR-642a-3p. The apin-like structure of "hsa-mir-642a" (miRBase Accession No. n No. MI0003657, sequence number 487) is known.

[0227] As used herein, the term "hsa-miR-6732-5p gene" or "hsa-mi The term "miR-6732-5p" refers to hsa-miR-6732 as set forth in SEQ ID NO: 152. -5p gene (miRBase Accession No. MIMAT0027365 ) and other species homologs or orthologs. The 32-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6732-5p has a hairpin-like structure as its precursor, hsa-mi r-6732" (miRBase Accession No. MI0022577, Column number 488) is known.

[0228] As used herein, the term "hsa-miR-6760-5p gene" or "hsa-mi The term "miR-6760-5p" refers to the miR-6760 -5p gene (miRBase Accession No. MIMAT0027420 ) and other species homologs or orthologs. The 60-5p gene is described in Ladewig E et al., 2012, Genome Res. It can be obtained by the method described in Vol. 22, pp. 1634-1645. sa-miR-6760-5p is a precursor of the hairpin-like structure hsa- mir-6760” (miRBase Accession No. MI0022605 , SEQ ID NO: 489) is known.

[0229] As used herein, the term "hsa-miR-6799-5p gene" or "hsa-mi The term "miR-6799-5p" refers to hsa-miR-6799 as set forth in SEQ ID NO: 154. -5p gene (miRBase Accession No. MIMAT0027498 ) and other species homologs or orthologs. The 99-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6799-5p has a hairpin-like structure as its precursor, hsa-mi r-6799” (miRBase Accession No. MI0022644, Column number 490) is known.

[0230] As used herein, the term "hsa-miR-6820-5p gene" or "hsa-mi The term "miR-6820-5p" refers to the miR-6820 -5p gene (miRBase Accession No. MIMAT0027540 ) and other species homologs or orthologs. The 20-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6820-5p has a hairpin-like structure as its precursor, hsa-mi r-6820" (miRBase Accession No. MI0022665, Column number 491) is known.

[0231] As used herein, the term "hsa-miR-6821-5p gene" or "hsa-mi The term "miR-6821-5p" refers to hsa-miR-6821 as set forth in SEQ ID NO: 156. -5p gene (miRBase Accession No. MIMAT0027542 ) and other species homologs or orthologs. The 21-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6821-5p has a hairpin-like structure as its precursor, hsa-mi r-6821" (miRBase Accession No. MI0022666, Column number 492) is known.

[0232] As used herein, the term "hsa-miR-6829-5p gene" or "hsa-mi The term "miR-6829-5p" refers to hsa-miR-6829 as set forth in SEQ ID NO: 157. -5p gene (miRBase Accession No. MIMAT0027558 ) and other species homologs or orthologs. The 29-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6829-5p has a hairpin-like structure as its precursor, hsa-mi r-6829” (miRBase Accession No. MI0022674, Column number 493) is known.

[0233] As used herein, the term "hsa-miR-6893-5p gene" or "hsa-mi The term "miR-6893-5p" refers to hsa-miR-6893 as set forth in SEQ ID NO: 158. -5p gene (miRBase Accession No. MIMAT0027686 ) and other species homologs or orthologs. The 93-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6893-5p has a hairpin-like structure as its precursor, hsa-mi r-6893" (miRBase Accession No. MI0022740, Column number 494) is known.

[0234] As used herein, the term "hsa-miR-7108-3p gene" or "hsa-mi The term "miR-7108-3p" refers to hsa-miR-7108 as set forth in SEQ ID NO: 159. -3p gene (miRBase Accession No. MIMAT0028114 ) and other species homologs or orthologs. The 08-3p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7108-3p has a hairpin-like structure as its precursor, hsa-mi r-7108” (miRBase Accession No. MI0022959, Column number 495) is known.

[0235] As used herein, the term "hsa-miR-7111-5p gene" or "hsa-mi The term "miR-7111-5p" refers to hsa-miR-7111 as set forth in SEQ ID NO: 160. -5p gene (miRBase Accession No. MIMAT0028119 ) and other species homologs or orthologs. The 11-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7111-5p has a hairpin-like structure as its precursor, hsa-mi r-7111" (miRBase Accession No. MI0022962, Column number 496) is known.

[0236] As used herein, "hsa-miR-8089 gene" or "hsa-miR-8 The term "miR-8089" refers to the hsa-miR-8089 gene (miR-8089) set forth in SEQ ID NO: 161. RBase Accession No. MIMAT0031016) and other species The hsa-miR-8089 gene is a homologue or ortholog of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8089" can be obtained as a precursor of hsa-miR-8089. The apin-like structure of "hsa-mir-8089" (miRBase Accession n No. MI0025925, sequence number 497) is known.

[0237] As used herein, "hsa-miR-885-3p gene" or "hsa-miR The term "miR-885-3p" refers to hsa-miR-885-3p as set forth in SEQ ID NO: 162. Gene (miRBase Accession No. MIMAT0004948) and Other species homologs or orthologs of hsa-miR-885-3 are also included. The p gene is described in Berezikov E et al., 2006, Genome Res, vol. 16, It can be obtained by the method described on pages 1289-1298 of the "HSA-M iR-885-3p is a precursor of hsa-mir-8, which has a hairpin-like structure. 85" (miRBase Accession No. MI0005560, SEQ ID NO: 4 98) is known.

[0238] As used herein, the term "hsa-miR-92b-3p gene" or "hsa-miR The term "miR-92b-3p" refers to the hsa-miR-92b-3p set forth in SEQ ID NO: 163. Gene (miRBase Accession No. MIMAT0003218) and Other species homologs or orthologs of hsa-miR-92b-3 are also included. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci USA, Vol. 103, p3687-3692. In addition, the precursor of "hsa-miR-92b-3p" has a hairpin-like structure. The structure of "hsa-mir-92b" (miRBase Accession No. I0003560, sequence number 499) is known.

[0239] As used herein, the term "hsa-miR-1343-3p gene" or "hsa-mi The term "miR-1343-3p" refers to hsa-miR-1343 as set forth in SEQ ID NO: 164. -3p gene (miRBase Accession No. MIMAT0019776 ) and other species homologs or orthologs. The 43-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -1343-3p is a precursor of hsa-mir-13, which has a hairpin-like structure. 43" (miRBase Accession No. MI0017320, SEQ ID NO: 5 00) is known.

[0240] As used herein, the term "hsa-miR-6746-5p gene" or "hsa-mi The term "miR-6746-5p" refers to hsa-miR-6746 as set forth in SEQ ID NO: 165. -5p gene (miRBase Accession No. MIMAT0027392 ) and other species homologs or orthologs. The 46-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6746-5p has a hairpin-like structure as its precursor, hsa-mi r-6746" (miRBase Accession No. MI0022591, Column number 501) is known.

[0241] As used herein, "hsa-miR-422a gene" or "hsa-miR-4 The term "miR-422a" refers to the hsa-miR-422a gene (mi RBase Accession No. MIMAT0001339) and other species The hsa-miR-422a gene is a member of the Ka Sashima K et al., 2004, Biochem Biophys Res Com It can be obtained by the method described in Mun, Vol. 322, p. 403-410. The precursor of "hsa-miR-422a" has a hairpin-like structure, mir-422a” (miRBase Accession No. MI0001444 , SEQ ID NO: 502) is known.

[0242] As used herein, "hsa-miR-187-5p gene" or "hsa-miR The term "miR-187-5p" refers to hsa-miR-187-5p as set forth in SEQ ID NO: 167. Gene (miRBase Accession No. MIMAT0004561) and Other species homologs or orthologs of hsa-miR-187-5 are also included. The p gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. The hsa-miR-187-5p can be obtained by the method described in Its precursor, hsa-mir-187 (miRBase Accession No. MI0000274, SEQ ID NO: 503) is known.

[0243] As used herein, the term "hsa-miR-4632-5p gene" or "hsa-mi The term "miR-4632-5p" refers to hsa-miR-4632 as set forth in SEQ ID NO: 168. -5p gene (miRBase Accession No. MIMAT0022977 ) and other species homologs or orthologs. The 32-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4632-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 32" (miRBase Accession No. MI0017259, SEQ ID NO: 5 04) is known.

[0244] As used herein, the term "hsa-miR-6791-5p gene" or "hsa-mi The term "miR-6791-5p" refers to hsa-miR-6791 as set forth in SEQ ID NO: 169. -5p gene (miRBase Accession No. MIMAT0027482 ) and other species homologs or orthologs. The 91-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6791-5p has a hairpin-like structure as its precursor, hsa-mi r-6791" (miRBase Accession No. MI0022636, Column number 505) is known.

[0245] As used herein, the term "hsa-miR-103a-3p gene" or "hsa-mi The term "miR-103a-3p" refers to hsa-miR-103a -3p gene (miRBase Accession No. MIMAT0000101 ) and other species homologs or orthologs. The 3a-3p genes are described in Mourelatos Z et al., 2002, Genes Dev. It can be obtained by the method described in Vol. 16, p. 720-728. sa-miR-103a-3p is a precursor of the hairpin-like structure hsa- mir-103a-2, hsa-mir-103a-1” (miRBase Acce Serial No. MI0000109, MI0000108, sequence numbers 506 and 507 ) is known.

[0246] As used herein, "hsa-miR-107 gene" or "hsa-miR-10 The term "miR-107" refers to the hsa-miR-107 gene (miRBa se Accession No. MIMAT0000104) and other species homologues or orthologues thereof. The hsa-miR-107 gene is Atos Z et al., 2002, Genes Dev., vol. 16, p720-728 The hsa-miR-107 can be obtained by the method described in the literature. The hairpin-like structure of the marker “hsa-mir-107” (miRBase Acc Session No. MI0000114, sequence number 508) is known.

[0247] As used herein, the term "hsa-miR-1199-5p gene" or "hsa-mi The term "miR-1199-5p" refers to hsa-miR-1199 as set forth in SEQ ID NO: 172. -5p gene (miRBase Accession No. MIMAT0031119 ) and other species homologs or orthologs. The 99-5p gene is Salvi A et al., 2013, Int J Oncol, Vol. 42 The hsa-mi can be obtained by the method described in the above. R-1199-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 199" (miRBase Accession No. MI0020340, SEQ ID NO: 509) is known.

[0248] As used herein, the term "hsa-miR-1225-3p gene" or "hsa-mi The term "miR-1225-3p" refers to the hsa-miR-1225 set forth in SEQ ID NO: 173. -3p gene (miRBase Accession No. MIMAT0005573 ) and other species homologs or orthologs. The 25-3p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1225-3p is a precursor of the hairpin-like structure known as hsa-mir- 1225" (miRBase Accession No. MI0006311, sequence no. No. 510) is known.

[0249] As used herein, the term "hsa-miR-1225-5p gene" or "hsa-mi The term "miR-1225-5p" refers to the hsa-miR-1225 set forth in SEQ ID NO: 174. -5p gene (miRBase Accession No. MIMAT0005572 ) and other species homologs or orthologs. The 25-5p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1225-5p is a precursor of the hairpin-like structure known as hsa-mir- 1225" (miRBase Accession No. MI0006311, sequence no. No. 510) is known.

[0250] As used herein, the term "hsa-miR-1228-5p gene" or "hsa-mi The term "miR-1228-5p" refers to hsa-miR-1228 as set forth in SEQ ID NO: 175. -5p gene (miRBase Accession No. MIMAT0005582 ) and other species homologs or orthologs. The 28-5p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1228-5p is a precursor of the hairpin-like structure known as hsa-mir- 1228" (miRBase Accession No. MI0006318, sequence no. No. 511) is known.

[0251] As used herein, the term "hsa-miR-1229-5p gene" or "hsa-mi The term "miR-1229-5p" refers to hsa-miR-1229 as set forth in SEQ ID NO: 176. -5p gene (miRBase Accession No. MIMAT0022942 ) and other species homologs or orthologs. The 29-5p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1229-5p is a precursor of the hairpin-like structure known as hsa-mir- 1229" (miRBase Accession No. MI0006319, sequence no. No. 512) is known.

[0252] As used herein, the term "hsa-miR-1233-5p gene" or "hsa-mi The term "miR-1233-5p" refers to hsa-miR-1233 as set forth in SEQ ID NO: 177. -5p gene (miRBase Accession No. MIMAT0022943 ) and other species homologs or orthologs. The 33-5p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1233-5p is a precursor of the hairpin-like structure known as hsa-mir- 1233-1, hsa-mir-1233-2” (miRBase Accession No. MI0006323, MI0015973, sequence numbers 513 and 514) are known. is.

[0253] As used herein, the term "hsa-miR-1237-5p gene" or "hsa-mi The term "miR-1237-5p" refers to hsa-miR-1237 as set forth in SEQ ID NO: 178. -5p gene (miRBase Accession No. MIMAT0022946 ) and other species homologs or orthologs. The 37-5p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1237-5p is a precursor of the hairpin-like structure known as hsa-mir- 1237" (miRBase Accession No. MI0006327, sequence no. No. 515) is known.

[0254] As used herein, the term "hsa-miR-1247-3p gene" or "hsa-mi The term "miR-1247-3p" refers to hsa-miR-1247 as set forth in SEQ ID NO: 179. -3p gene (miRBase Accession No. MIMAT0022721 ) and other species homologs or orthologs. The 47-3p gene is Morin RD et al., 2008, Genome Res, vol. 18 The hsa-mi can be obtained by the method described in the above. R-1247-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 247" (miRBase Accession No. MI0006382, SEQ ID NO: 516) is known.

[0255] As used herein, the term "hsa-miR-1249-3p gene" or "hsa-mi The term "miR-1249-3p" refers to hsa-miR-1249 as set forth in SEQ ID NO: 180. -3p gene (miRBase Accession No. MIMAT0005901 ) and other species homologs or orthologs. The 49-3p gene is Morin RD et al., 2008, Genome Res, vol. 18 The hsa-mi can be obtained by the method described in the above. R-1249-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 249" (miRBase Accession No. MI0006384, SEQ ID NO: 343) is known.

[0256] As used herein, "hsa-miR-1254 gene" or "hsa-miR-1 The term "miR-1254" refers to the hsa-miR-1254 gene (miR-1254) set forth in SEQ ID NO: 181. RBase Accession No. MIMAT0005905) and other species The hsa-miR-1254 gene is a member of the Mo Rin RD et al., 2008, Genome Res, vol. 18, p610-621 In addition, "hsa-miR-1254" can be obtained by the method described above. The hairpin-like structures of the markers hsa-mir-1254-1 and hsa-mir-1 254-2” (miRBase Accession No. MI0006388, MI 0016747, SEQ ID NOs: 517 and 518) are known.

[0257] As used herein, "hsa-miR-1260b gene" or "hsa-miR- The term "miR-1260b" refers to the hsa-miR-1260b gene set forth in SEQ ID NO: 182. (miRBase Accession No. MIMAT0015041) and other Species homologs or orthologs are included. hsa-miR-1260b gene is described in Stark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-1260b" can be obtained by the method described above. The miRBase AcDNA clone "hsa-mir-1260b" (miRBase AcDNA clone) has a hairpin-like structure as a target. Accession No. MI0014197, SEQ ID NO: 519) is known.

[0258] As used herein, "hsa-miR-1268a gene" or "hsa-miR- The term "miR-1268a" refers to the hsa-miR-1268a gene set forth in SEQ ID NO: 183. (miRBase Accession No. MIMAT0005922) and other Species homologs or orthologs are included. hsa-miR-1268a gene Morin RD et al., 2008, Genome Res, vol. 18, p610-62 1. Also, "hsa-miR-1268a" can be obtained by the method described in The precursor of miRB is a hairpin-like structure called hsa-mir-1268a (miRB1). ase Accession No. MI0006405, SEQ ID NO: 520) is known. There are.

[0259] As used herein, "hsa-miR-1268b gene" or "hsa-miR- The term "miR-1268b" refers to the hsa-miR-1268b gene set forth in SEQ ID NO: 184. (miRBase Accession No. MIMAT0018925) and other Species homologs or orthologs are included. hsa-miR-1268b gene Jima DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-1268b" can be obtained by the method described above. The precursor of "hsa-mir-1268b" (miRBase Accession No. MI0016748, SEQ ID NO: 521) is known.

[0260] As used herein, the term "hsa-miR-1273g-3p gene" or "hsa-m The term "hsa-miR-1273g-3p" refers to the hsa-miR-12 73g-3p gene (miRBase Accession No. MIMAT0022 742) and other species homologs or orthologs. The -1273g-3p gene is described in Reshmi G et al., 2011, Genomics, 9 It can be obtained by the method described in Vol. 7, pp. 333-340. miR-1273g-3p is a precursor of the hairpin-like structure known as hsa-miR r-1273g” (miRBase Accession No. MI0018003, SEQ ID NO: 522) is known.

[0261] As used herein, "hsa-miR-128-1-5p gene" or "hsa-m The term "hsa-miR-128-1-5p" refers to the hsa-miR-12 8-1-5p gene (miRBase Accession No. MIMAT0026 477) and other species homologs or orthologs. The -128-1-5p gene was identified in Lagos-Quintana M et al., 2002, It can be obtained by the method described in rr Biol, vol. 12, p735-739. In addition, "hsa-miR-128-1-5p" has a hairpin-like structure as its precursor. The target gene, "hsa-mir-128-1" (miRBase Accession No. I0000447, sequence number 523) is known.

[0262] As used herein, "hsa-miR-128-2-5p gene" or "hsa-m The term "hsa-miR-128-2-5p" refers to the hsa-miR-12 8-2-5p gene (miRBase Accession No. MIMAT0031 095) and other species homologs or orthologs. The -128-2-5p gene was identified in Lagos-Quintana M et al., 2002, It can be obtained by the method described in rr Biol, vol. 12, p735-739. In addition, "hsa-miR-128-2-5p" has a hairpin-like structure as its precursor. The target gene, "hsa-mir-128-2" (miRBase Accession No. I0000727, sequence number 524) is known.

[0263] As used herein, "hsa-miR-1290 gene" or "hsa-miR-1 The term "miR-1290" refers to the hsa-miR-1290 gene (miR-1290) set forth in SEQ ID NO: 188. RBase Accession No. MIMAT0005880) and other species The hsa-miR-1290 gene is a member of the Mo Rin RD et al., 2008, Genome Res, vol. 18, p610-621 In addition, "hsa-miR-1290" can be obtained by the method described above. The hairpin-like structure of the carrier protein "hsa-mir-1290" (miRBase Ac Accession No. MI0006352, SEQ ID NO: 525) is known.

[0264] As used herein, "hsa-miR-150-3p gene" or "hsa-miR The term "miR-150-3p" refers to the hsa-miR-150-3p set forth in SEQ ID NO: 189. Gene (miRBase Accession No. MIMAT0004610) and Other species homologs or orthologs of hsa-miR-150-3 are also included. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. It can be obtained by the method described in Vol. 12, p. 735-739. -miR-150-3p has a hairpin-like structure as its precursor, hsa-mir -150" (miRBase Accession No. MI0000479, sequence no. No. 526) is known.

[0265] As used herein, "hsa-miR-17-3p gene" or "hsa-miR- The term "miR-17-3p" refers to the hsa-miR-17-3p gene set forth in SEQ ID NO: 190. (miRBase Accession No. MIMAT0000071) and other Species homologs or orthologs are included. hsa-miR-17-3p gene Lagos-Quintana M et al., 2001, Science., vol. 294 The hsa-mi can be obtained by the method described in the above. R-17-3p has a hairpin-like structure as its precursor, hsa-mir-17. (miRBase Accession No. MI0000071, SEQ ID NO: 527) It is known that.

[0266] As used herein, the term "hsa-miR-1908-5p gene" or "hsa-mi The term "miR-1908-5p" refers to hsa-miR-1908 as set forth in SEQ ID NO: 191. -5p gene (miRBase Accession No. MIMAT0007881 ) and other species homologs or orthologs. The 08-5p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 2 The hsa-miR -1908-5p is a precursor of hsa-mir-19, which has a hairpin-like structure. 08" (miRBase Accession No. MI0008329, SEQ ID NO: 5 28) is known.

[0267] As used herein, the term "hsa-miR-1909-3p gene" or "hsa-mi The term "miR-1909-3p" refers to hsa-miR-1909 as set forth in SEQ ID NO: 192. -3p gene (miRBase Accession No. MIMAT0007883 ) and other species homologs or orthologs. The 09-3p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 2 The hsa-miR -1909-3p is a precursor of hsa-mir-19, which has a hairpin-like structure. 09" (miRBase Accession No. MI0008330, SEQ ID NO: 5 29) is known.

[0268] As used herein, the term "hsa-miR-1914-3p gene" or "hsa-mi The term "miR-1914-3p" refers to hsa-miR-1914 as set forth in SEQ ID NO: 193. -3p gene (miRBase Accession No. MIMAT0007890 ) and other species homologs or orthologs. The 14-3p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 2 The hsa-miR -1914-3p is a precursor of hsa-mir-19, which has a hairpin-like structure. 14" (miRBase Accession No. MI0008335, SEQ ID NO: 5 30) is known.

[0269] As used herein, the term "hsa-miR-1915-3p gene" or "hsa-mi The term "miR-1915-3p" refers to hsa-miR-1915 as set forth in SEQ ID NO: 194. -3p gene (miRBase Accession No. MIMAT0007892 ) and other species homologs or orthologs. The 15-3p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 2 The hsa-miR -1915-3p is a precursor of hsa-mir-19, which has a hairpin-like structure. 15" (miRBase Accession No. MI0008336, SEQ ID NO: 5 31) is known.

[0270] As used herein, "hsa-miR-191-5p gene" or "hsa-miR The term "miR-191-5p" refers to hsa-miR-191-5p as set forth in SEQ ID NO: 195. Gene (miRBase Accession No. MIMAT0000440) and Other species homologs or orthologs of hsa-miR-191-5 are also included. The p gene is from Lagos-Quintana M et al., 2003, RNA, vol. 9, p17 The hsa-miR-19 can be obtained by the method described in US Pat. 1-5p" has a hairpin-like structure as its precursor "hsa-mir-191" (m iRBase Accession No. MI0000465, sequence number 532) is known. It is being done.

[0271] As used herein, "hsa-miR-22-3p gene" or "hsa-miR- The term "miR-22-3p" refers to the hsa-miR-22-3p gene set forth in SEQ ID NO: 196. (miRBase Accession No. MIMAT0000077) and other Species homologs or orthologs are included. hsa-miR-22-3p gene Lagos-Quintana M et al., 2001, Science, vol. 294, p. The hsa-miR- 22-3p" is a precursor of "hsa-mir-22" (m iRBase Accession No. MI0000078, sequence number 533) is known. It is being done.

[0272] As used herein, "hsa-miR-23b-3p gene" or "hsa-miR The term "miR-23b-3p" refers to hsa-miR-23b-3p as set forth in SEQ ID NO: 197. Gene (miRBase Accession No. MIMAT0000418) and Other species homologs or orthologs of hsa-miR-23b-3 are also included. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. It can be obtained by the method described in Vol. 12, p. 735-739. -miR-23b-3p has a hairpin-like structure as its precursor, hsa-mir -23b" (miRBase Accession No. MI0000439, sequence no. No. 534) is known.

[0273] As used herein, "hsa-miR-24-3p gene" or "hsa-miR- The term "miR-24-3p" refers to the hsa-miR-24-3p gene set forth in SEQ ID NO: 198. (miRBase Accession No. MIMAT0000080) and other Species homologs or orthologs are included. hsa-miR-24-3p gene Lagos-Quintana M et al., 2001, Science, vol. 294, p. The hsa-miR- 24-3p has a hairpin-like structure as its precursor, hsa-mir-24-1, hsa-mir-24-2” (miRBase Accession No. MI000 0080, MI0000081, sequence numbers 535 and 536) are known.

[0274] As used herein, "hsa-miR-296-3p gene" or "hsa-miR The term "miR-296-3p" refers to hsa-miR-296-3p as set forth in SEQ ID NO: 199. Gene (miRBase Accession No. MIMAT0004679) and Other species homologs or orthologs of hsa-miR-296-3 are also included. The p gene is Houbaviy HB et al., 2003, Dev Cell, vol. 5, p35 The hsa-miR-29 can be obtained by the method described in US Pat. 6-3p" has a hairpin-like structure as its precursor "hsa-mir-296" (m iRBase Accession No. MI0000747, sequence number 537) is known. It is being done.

[0275] As used herein, "hsa-miR-296-5p gene" or "hsa-miR The term "miR-296-5p" refers to hsa-miR-296-5p as set forth in SEQ ID NO: 200. Gene (miRBase Accession No. MIMAT0000690) and Other species homologs or orthologs of hsa-miR-296-5 are also included. The p gene is Houbaviy HB et al., 2003, Dev Cell, vol. 5, p35 The hsa-miR-29 can be obtained by the method described in US Pat. 6-5p" has a hairpin-like structure as its precursor "hsa-mir-296" (m iRBase Accession No. MI0000747, sequence number 537) is known. It is being done.

[0276] As used herein, "hsa-miR-3131 gene" or "hsa-miR-3 The term "miR-3131" refers to the hsa-miR-3131 gene (miR-3131) set forth in SEQ ID NO: 201. RBase Accession No. MIMAT0014996) and other species The hsa-miR-3131 gene is a member of the St Ark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3131" can be obtained as a precursor of hsa-miR-3131. The apin-like structure of "hsa-mir-3131" (miRBase Accession No. n No. MI0014151, sequence number 538) is known.

[0277] As used herein, the term "hsa-miR-3162-5p gene" or "hsa-mi The term "miR-3162-5p" refers to hsa-miR-3162 as set forth in SEQ ID NO: 202. -5p gene (miRBase Accession No. MIMAT0015036 ) and other species homologs or orthologs. The 62-5p gene is Stark MS et al., 2010, PLoS One, vol. 5, e9 The miR-3162 can be obtained by the method described in 685. -5p" has a hairpin-like structure as its precursor "hsa-mir-3162" (m iRBase Accession No. MI0014192, sequence number 539) is known. It is being done.

[0278] As used herein, "hsa-miR-3188 gene" or "hsa-miR-3 The term "miR-3188" refers to the hsa-miR-3188 gene (miR-3188) set forth in SEQ ID NO: 203. RBase Accession No. MIMAT0015070) and other species The hsa-miR-3188 gene is a member of the St Ark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3188" can be obtained as a precursor of hsa-miR-3188. The apin-like structure of "hsa-mir-3188" (miRBase Accession n No. MI0014232, sequence number 540) is known.

[0279] As used herein, "hsa-miR-3196 gene" or "hsa-miR-3 The term "miR-3196" refers to the hsa-miR-3196 gene (miR-3196) set forth in SEQ ID NO: 204. RBase Accession No. MIMAT0015080) and other species The hsa-miR-3196 gene is a member of the St Ark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3196" can be obtained as a precursor of hsa-miR-3196. The apin-like structure of "hsa-mir-3196" (miRBase Accession n No. MI0014241, sequence number 541) is known.

[0280] As used herein, "hsa-miR-3197 gene" or "hsa-miR-3 The term "miR-3197" refers to the hsa-miR-3197 gene (miR-3197) set forth in SEQ ID NO: 205. RBase Accession No. MIMAT0015082) and other species The hsa-miR-3197 gene is a member of the St Ark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3197" can be obtained as a precursor of hsa-miR-3197. The apin-like structure of "hsa-mir-3197" (miRBase Accession No. n No. MI0014245, sequence number 542) is known.

[0281] As used herein, the term "hsa-miR-320a gene" or "hsa-miR-3 The term "miR-320a" refers to the hsa-miR-320a gene (mi RBase Accession No. MIMAT0000510) and other species The hsa-miR-320a gene is a homologue or ortholog of the Mi Chael MZ et al., 2003, Mol Cancer Res, Vol. 1, p882-8 91. Also, "hsa-miR-320a" can be obtained by the method described in miRBa is a precursor of the hairpin-like structure hsa-mir-320a (miRBa se Accession No. MI0000542, SEQ ID NO: 543) is known. do.

[0282] As used herein, "hsa-miR-342-5p gene" or "hsa-miR The term "miR-342-5p" refers to hsa-miR-342-5p as set forth in SEQ ID NO: 207. Gene (miRBase Accession No. MIMAT0004694) and Other species homologs or orthologs of hsa-miR-342-5 are also included. The p gene is described in Kim J et al., 2004, Proc Natl Acad Sci U It can be obtained by the method described in SA, Vol. 101, p. 360-365. The precursor of "hsa-miR-342-5p" is "hs a-mir-342” (miRBase Accession No. MI000080 5, SEQ ID NO:544) is known.

[0283] As used herein, "hsa-miR-3621 gene" or "hsa-miR-3 The term "miR-3621" refers to the hsa-miR-3621 gene (mi RBase Accession No. MIMAT0018002) and other species The hsa-miR-3621 gene is a homologue or ortholog. According to the method described in tten D et al., 2010, BMC Biol, vol. 8, p. 58 In addition, "hsa-miR-3621" can be obtained by using hairpin as a precursor. The miRBase Accession No. 1366621 (hsa-mir-3621) has a mitochondrial structure similar to that of the miR No. MI0016012, sequence number 545) are known.

[0284] As used herein, the term "hsa-miR-3648 gene" or "hsa-miR-3 The term "miR-3648" refers to the hsa-miR-3648 gene (mi RBase Accession No. MIMAT0018068) and other species The hsa-miR-3648 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res, Vol. 38, p. 6234 The miR-36 can be obtained by the method described in US Pat. 48" has a hairpin-like structure as its precursor, "hsa-mir-3648" (mi RBase Accession No. MI0016048, sequence number 546) is known. It is being done.

[0285] As used herein, the term "hsa-miR-3656 gene" or "hsa-miR-3 The term "miR-3656" refers to the hsa-miR-3656 gene (mi RBase Accession No. MIMAT0018076) and other species The hsa-miR-3656 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res, Vol. 38, p. 6234 The miR-36 can be obtained by the method described in US Pat. The precursor of "hsa-mir-3656" (mi 56) has a hairpin-like structure. RBase Accession No. MI0016056, sequence number 547) is known. It is being done.

[0286] As used herein, the term "hsa-miR-365a-5p gene" or "hsa-mi The term "miR-365a-5p" refers to hsa-miR-365a as set forth in SEQ ID NO: 211. -5p gene (miRBase Accession No. MIMAT0009199 ) and other species homologs or orthologs. The 5a-5p gene is Xie X et al., 2005, Nature, vol. 434, p. 338- The miR-365a gene can be obtained by the method described in 345. -5p" is a precursor of "hsa-mir-365a" (m iRBase Accession No. MI0000767, sequence number 548) is known. It is being done.

[0287] As used herein, the term "hsa-miR-3665 gene" or "hsa-miR-3 The term "miR-3665" refers to the hsa-miR-3665 gene (miR-3665) set forth in SEQ ID NO: 212. RBase Accession No. MIMAT0018087) and other species The hsa-miR-3665 gene is a homologue or ortholog. ie X et al., 2005, Nature, Vol. 434, p. 338-345' The precursor of hsa-miR-3665 is The hairpin-like structure of “hsa-mir-3665” (miRBase Accession No. ion No. MI0016066, sequence number 549) is known.

[0288] As used herein, the term "hsa-miR-3679-5p gene" or "hsa-mi The term "miR-3679-5p" refers to hsa-miR-3679 as set forth in SEQ ID NO: 213. -5p gene (miRBase Accession No. MIMAT0018104 ) and other species homologs or orthologs. The 79-5p gene is Creighton CJ et al., 2010, PLoS One, 5 The miR-hsa gene can be obtained by the method described in Vol. 1, e9637. 3679-5p is a precursor of hsa-mir-367, which has a hairpin-like structure. 9" (miRBase Accession No. MI0016080, SEQ ID NO: 55 0) is known.

[0289] As used herein, the term "hsa-miR-371a-5p gene" or "hsa-mi The term "miR-371a-5p" refers to hsa-miR-371a -5p gene (miRBase Accession No. MIMAT0004687 ) and other species homologs or orthologs. The 1a-5p gene is described in Suh MR et al., 2004, Dev Biol, vol. 270, p. 4 The hsa-miR-3 can be obtained by the method described in 71a-5p is a precursor of hsa-mir-371a, which has a hairpin-like structure. " (miRBase Accession No. MI0000779, SEQ ID NO: 551 ) is known.

[0290] As used herein, the term "hsa-miR-3940-5p gene" or "hsa-mi The term "miR-3940-5p" refers to the hsa-miR-3940 -5p gene (miRBase Accession No. MIMAT0019229 ) and other species homologs or orthologs. The 40-5p gene is Liao JY et al., 2010, PLoS One, vol. 5, e10 The miR-3940 can be obtained by the method described in 563. -5p" has a hairpin-like structure as its precursor "hsa-mir-3940" (m iRBase Accession No. MI0016597, sequence number 552) is known. It is being done.

[0291] As used herein, "hsa-miR-423-5p gene" or "hsa-miR The term "miR-423-5p" refers to hsa-miR-423-5p as set forth in SEQ ID NO: 216. Gene (miRBase Accession No. MIMAT0004748) and Other species homologs or orthologs of hsa-miR-423-5 are also included. The p gene was described in Kasashima K et al., 2004, Biochem Biophys. Res Commun, vol. 322, p. 403-410. In addition, "hsa-miR-423-5p" has a hairpin-like structure as its precursor. The structure of “hsa-mir-423” (miRBase Accession No. MI0001445, sequence number 553) is known.

[0292] As used herein, "hsa-miR-4257 gene" or "hsa-miR-4 The term "miR-4257" refers to the hsa-miR-4257 gene set forth in SEQ ID NO: 217 (mi RBase Accession No. MIMAT0016878) and other species The hsa-miR-4257 gene is a Go ff LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4257" can be obtained by The pin-like structure of "hsa-mir-4257" (miRBase Accession No. MI0015856, sequence number 554) are known.

[0293] As used herein, "hsa-miR-4270 gene" or "hsa-miR-4 The term "miR-4270" refers to the hsa-miR-4270 gene set forth in SEQ ID NO: 218 (mi RBase Accession No. MIMAT0016900) and other species The hsa-miR-4270 gene is a homologue of Go ff LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4270" can be obtained by The pin-like structure of "hsa-mir-4270" (miRBase Accession No. MI0015878, sequence number 555) are known.

[0294] As used herein, "hsa-miR-4271 gene" or "hsa-miR-4 The term "miR-4271" refers to the hsa-miR-4271 gene set forth in SEQ ID NO: 219 (mi RBase Accession No. MIMAT0016901) and other species The hsa-miR-4271 gene is a Go ff LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4271" can be obtained by The pin-like structure of "hsa-mir-4271" (miRBase Accession No. MI0015879, sequence number 556) are known.

[0295] As used herein, "hsa-miR-4286 gene" or "hsa-miR-4 The term "miR-4286" refers to the hsa-miR-4286 gene (mi RBase Accession No. MIMAT0016916) and other species The hsa-miR-4286 gene is a Go ff LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4286" can be obtained by The pin-like structure of "hsa-mir-4286" (miRBase Accession No. MI0015894, sequence number 557) are known.

[0296] As used herein, "hsa-miR-4298 gene" or "hsa-miR-4 The term "miR-4298" refers to the hsa-miR-4298 gene set forth in SEQ ID NO: 221 (mi RBase Accession No. MIMAT0016852) and other species The hsa-miR-4298 gene is a Go ff LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4298" can be obtained by The pin-like structure of "hsa-mir-4298" (miRBase Accession No. MI0015830, sequence number 558) are known.

[0297] As used herein, "hsa-miR-4417 gene" or "hsa-miR-4 The term "miR-4417" refers to the hsa-miR-4417 gene set forth in SEQ ID NO: 222 (mi RBase Accession No. MIMAT0018929) and other species The hsa-miR-4417 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4417 is The hairpin-like structure of “hsa-mir-4417” (miRBase Accession No. ion No. MI0016753, sequence number 559) is known.

[0298] As used herein, "hsa-miR-4442 gene" or "hsa-miR-4 The term "miR-4442" refers to the hsa-miR-4442 gene set forth in SEQ ID NO: 223 (mi RBase Accession No. MIMAT0018960) and other species The hsa-miR-4442 gene is a member of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4442 is The hairpin-like structure of “hsa-mir-4442” (miRBase Accession No. ion No. MI0016785, sequence number 560) is known.

[0299] As used herein, the term "hsa-miR-4446-3p gene" or "hsa-mi The term "miR-4446-3p" refers to hsa-miR-4446 as set forth in SEQ ID NO: 224. -3p gene (miRBase Accession No. MIMAT0018965 ) and other species homologs or orthologs. The 46-3p gene is described in Jima DD et al., 2010, Blood, vol. 116, e118. The miR-44 gene can be obtained by the method described in . "46-3p" has a hairpin-like structure as its precursor "hsa-mir-4446" (miRBase Accession No. MI0016789, SEQ ID NO: 561) It is known that.

[0300] As used herein, "hsa-miR-4448 gene" or "hsa-miR-4 The term "miR-4448" refers to the hsa-miR-4448 gene set forth in SEQ ID NO: 225 (mi RBase Accession No. MIMAT0018967) and other species The hsa-miR-4448 gene is a member of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4448 is The hairpin-like structure of “hsa-mir-4448” (miRBase Accession No. ion No. MI0016791, sequence number 562) is known.

[0301] As used herein, "hsa-miR-4454 gene" or "hsa-miR-4 The term "miR-4454" refers to the hsa-miR-4454 gene set forth in SEQ ID NO: 226 (mi RBase Accession No. MIMAT0018976) and other species The hsa-miR-4454 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4454 is The hairpin-like structure of “hsa-mir-4454” (miRBase Accession No. ion No. MI0016800, sequence number 563) is known.

[0302] As used herein, "hsa-miR-4467 gene" or "hsa-miR-4 The term "miR-4467" refers to the hsa-miR-4467 gene set forth in SEQ ID NO: 227 (mi RBase Accession No. MIMAT0018994) and other species The hsa-miR-4467 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4467 is The hairpin-like structure of “hsa-mir-4467” (miRBase Accession No. ion No. MI0016818, sequence number 564) is known.

[0303] As used herein, "hsa-miR-4472 gene" or "hsa-miR-4 The term "miR-4472" refers to the hsa-miR-4472 gene set forth in SEQ ID NO: 228 (mi RBase Accession No. MIMAT0018999) and other species The hsa-miR-4472 gene is a member of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4472 is The hairpin-like structures of hsa-mir-4472-1 and hsa-mir-4472- 2” (miRBase Accession No. MI0016823, MI0016 824, SEQ ID NOs: 565 and 566) are known.

[0304] As used herein, "hsa-miR-4507 gene" or "hsa-miR-4 The term "miR-4507" refers to the hsa-miR-4507 gene (mi RBase Accession No. MIMAT0019044) and other species The hsa-miR-4507 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4507 is The hairpin-like structure of “hsa-mir-4507” (miRBase Accession No. ion No. MI0016871, sequence number 567) is known.

[0305] As used herein, "hsa-miR-4516 gene" or "hsa-miR-4 The term "miR-4516" refers to the hsa-miR-4516 gene (mi RBase Accession No. MIMAT0019053) and other species The hsa-miR-4516 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4516 is The hairpin-like structure of “hsa-mir-4516” (miRBase Accession No. ion No. MI0016882, sequence number 568) are known.

[0306] As used herein, "hsa-miR-451a gene" or "hsa-miR-4 The term "miR-451a" refers to the hsa-miR-451a gene (mi RBase Accession No. MIMAT0001631) and other species The hsa-miR-451a gene is a homologue or ortholog. Tuvia Y et al., 2005, Nucleic Acids Res, Vol. 33, p. 26 The hsa-miR- 451a" has a hairpin-like structure as its precursor "hsa-mir-451a" ( miRBase Accession No. MI0001729, SEQ ID NO: 569) It is known.

[0307] As used herein, the term "hsa-miR-4649-5p gene" or "hsa-mi The term "miR-4649-5p" refers to hsa-miR-4649 as set forth in SEQ ID NO: 232. -5p gene (miRBase Accession No. MIMAT0019711 ) and other species homologs or orthologs. The 49-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4649-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 49" (miRBase Accession No. MI0017276, SEQ ID NO: 5 70) is known.

[0308] As used herein, "hsa-miR-4651 gene" or "hsa-miR-4 The term "miR-4651" refers to the hsa-miR-4651 gene (miR-4651) set forth in SEQ ID NO: 233. RBase Accession No. MIMAT0019715) and other species The hsa-miR-4651 gene is a homologue or ortholog of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4651" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4651) has a hairpin-like structure as a target gene. Session No. MI0017279, sequence number 571) is known.

[0309] As used herein, the term "hsa-miR-4665-3p gene" or "hsa-mi The term "miR-4665-3p" refers to hsa-miR-4665 as set forth in SEQ ID NO: 234. -3p gene (miRBase Accession No. MIMAT0019740 ) and other species homologs or orthologs. The 65-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4665-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 65" (miRBase Accession No. MI0017295, SEQ ID NO: 4 01) is known.

[0310] As used herein, "hsa-miR-4674 gene" or "hsa-miR-4 The term "miR-4674" refers to the hsa-miR-4674 gene (mi RBase Accession No. MIMAT0019756) and other species The hsa-miR-4674 gene is a member of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4674" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4674) has a hairpin-like structure as a target gene. Session No. MI0017305, sequence number 572) is known.

[0311] As used herein, "hsa-miR-4675 gene" or "hsa-miR-4 The term "miR-4675" refers to the hsa-miR-4675 gene (mi RBase Accession No. MIMAT0019757) and other species The hsa-miR-4675 gene is a homologue or ortholog of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4675" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4675) has a hairpin-like structure as a target gene. Session No. MI0017306, sequence number 573) is known.

[0312] As used herein, "hsa-miR-4689 gene" or "hsa-miR-4 The term "miR-4689" refers to the hsa-miR-4689 gene (mi RBase Accession No. MIMAT0019778) and other species The hsa-miR-4689 gene is a homologue or ortholog of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4689" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4689) has a hairpin-like structure as a target protein. Session No. MI0017322, sequence number 574) is known.

[0313] As used herein, the term "hsa-miR-4695-5p gene" or "hsa-mi The term "miR-4695-5p" refers to hsa-miR-4695 as set forth in SEQ ID NO: 238. -5p gene (miRBase Accession No. MIMAT0019788 ) and other species homologs or orthologs. The 95-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4695-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 95" (miRBase Accession No. MI0017328, SEQ ID NO:5 75) is known.

[0314] As used herein, the term "hsa-miR-4697-5p gene" or "hsa-mi The term "miR-4697-5p" refers to hsa-miR-4697 as set forth in SEQ ID NO: 239. -5p gene (miRBase Accession No. MIMAT0019791 ) and other species homologs or orthologs. The 97-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4697-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 97" (miRBase Accession No. MI0017330, SEQ ID NO: 5 76) is known.

[0315] As used herein, the term "hsa-miR-4725-3p gene" or "hsa-mi The term "miR-4725-3p" refers to hsa-miR-4725 as set forth in SEQ ID NO: 240. -3p gene (miRBase Accession No. MIMAT0019844 ) and other species homologs or orthologs. The 25-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4725-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 25" (miRBase Accession No. MI0017362, SEQ ID NO: 5 77) is known.

[0316] As used herein, "hsa-miR-4739 gene" or "hsa-miR-4 The term "miR-4739" refers to the hsa-miR-4739 gene (mi RBase Accession No. MIMAT0019868) and other species The hsa-miR-4739 gene is a homologue or ortholog of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4739" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4739) has a hairpin-like structure as a target gene. Session No. MI0017377, sequence number 578) is known.

[0317] As used herein, the term "hsa-miR-4745-5p gene" or "hsa-mi The term "miR-4745-5p" refers to hsa-miR-4745 as set forth in SEQ ID NO: 242. -5p gene (miRBase Accession No. MIMAT0019878 ) and other species homologs or orthologs. The 45-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4745-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 45" (miRBase Accession No. MI0017384, SEQ ID NO: 5 79) is known.

[0318] As used herein, the term "hsa-miR-4763-3p gene" or "hsa-mi The term "miR-4763-3p" refers to hsa-miR-4763 as set forth in SEQ ID NO: 243. -3p gene (miRBase Accession No. MIMAT0019913 ) and other species homologs or orthologs. The 63-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4763-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 63" (miRBase Accession No. MI0017404, SEQ ID NO: 4 15) is known.

[0319] As used herein, "hsa-miR-4792 gene" or "hsa-miR-4 The term "miR-4792" refers to the hsa-miR-4792 gene (mi RBase Accession No. MIMAT0019964) and other species The hsa-miR-4792 gene is a member of the Pe rsson H et al., 2011, Cancer Res, vol. 71, p78-86 In addition, "hsa-miR-4792" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-4792) has a hairpin-like structure as a target protein. Session No. MI0017439, sequence number 580) is known.

[0320] As used herein, "hsa-miR-486-3p gene" or "hsa-miR The term "miR-486-3p" refers to hsa-miR-486-3p as set forth in SEQ ID NO: 245. Gene (miRBase Accession No. MIMAT0004762) and Other species homologs or orthologs of hsa-miR-486-3 are also included. p gene, Fu H et al., 2005, FEBS Lett, vol. 579, p3849-3 The miR-486 can be obtained by the method described in U.S. Pat. "3p" has a hairpin-like structure as its precursor "hsa-mir-486, hsa- mir-486-2” (miRBase Accession No. MI000247 0, MI0023622, sequence numbers 581 and 582) are known.

[0321] As used herein, the term "hsa-miR-5001-5p gene" or "hsa-mi The term "miR-5001-5p" refers to hsa-miR-5001 as set forth in SEQ ID NO: 246. -5p gene (miRBase Accession No. MIMAT0021021 ) and other species homologs or orthologs. The 01-5p gene is described in Hansen TB et al., 2011, RNA Biol, vol. 8, p. The hsa-miR- 5001-5p is a precursor of hsa-mir-500, which has a hairpin-like structure. 1" (miRBase Accession No. MI0017867, SEQ ID NO: 58 3) is known.

[0322] As used herein, the term "hsa-miR-5195-3p gene" or "hsa-mi The term "miR-5195-3p" refers to hsa-miR-5195 as set forth in SEQ ID NO: 247. -3p gene (miRBase Accession No. MIMAT0021127 ) and other species homologs or orthologs. The 95-3p gene is described in Schotte D et al., 2011, Leukemia, Vol. 25, It can be obtained by the method described in p. 1389-1399. iR-5195-3p is a precursor of the hairpin-like structure known as hsa-mir- 5195" (miRBase Accession No. MI0018174, sequence no. No. 584) is known.

[0323] As used herein, the term "hsa-miR-550a-5p gene" or "hsa-mi The term "miR-550a-5p" refers to hsa-miR-550a as set forth in SEQ ID NO: 248. -5p gene (miRBase Accession No. MIMAT0004800 ) and other species homologs or orthologs. The 0a-5p gene is described in Cummins JM, 2006, Proc Natl Aca d Sci, Vol. 103, p3687-3692. In addition, "hsa-miR-550a-5p" has a hairpin-like structure as its precursor. Take "hsa-mir-550a-1, hsa-mir-550a-2" (miRBas e Accession No. MI0003600, MI0003601, SEQ ID NO:5 85, 586) are known.

[0324] As used herein, "hsa-miR-5698 gene" or "hsa-miR-5 The term "miR-5698" refers to the hsa-miR-5698 gene (mi RBase Accession No. MIMAT0022491) and other species The hsa-miR-5698 gene is a member of the Wa Tahiki A et al., 2011, PLoS One, Vol. 6, e24950 The precursor of hsa-miR-5698 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-5698" (miRBase Access sion No. MI0019305, sequence number 587) is known.

[0325] As used herein, "hsa-miR-6075 gene" or "hsa-miR-6 The term "miR-6075" refers to the hsa-miR-6075 gene (miR-6075) set forth in SEQ ID NO: 250. RBase Accession No. MIMAT0023700) and other species The hsa-miR-6075 gene is a member of the Vo Described in Ellenkle C et al., 2012, RNA, vol. 18, p. 472-484 The precursor of hsa-miR-6075 can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-6075) has a hairpin-like structure. sion No. MI0020352, sequence number 588) are known.

[0326] As used herein, "hsa-miR-6088 gene" or "hsa-miR-6 The term "miR-6088" refers to the hsa-miR-6088 gene (miR-6088) set forth in SEQ ID NO: 251. RBase Accession No. MIMAT0023713) and other species The hsa-miR-6088 gene is a member of the Yo o JK et al., 2012, Stem Cells Dev, vol. 21, p2049-205 7. In addition, "hsa-miR-6088" can be obtained by the method described in , and its precursor, "hsa-mir-6088" (miRBas e Accession No. MI0020365, SEQ ID NO: 589) is known. .

[0327] As used herein, "hsa-miR-6089 gene" or "hsa-miR-6 The term "miR-6089" refers to the hsa-miR-6089 gene (miR-6089) set forth in SEQ ID NO: 252. RBase Accession No. MIMAT0023714) and other species The hsa-miR-6089 gene is a member of the Yo o JK et al., 2012, Stem Cells Dev, vol. 21, p2049-205 7. In addition, "hsa-miR-6089" can be obtained by the method described in The precursors of these proteins have hairpin-like structures, such as hsa-mir-6089-1 and hsa-m ir-6089-2” (miRBase Accession No. MI002036 6, MI0023563, SEQ ID NOs: 590 and 591) are known.

[0328] As used herein, "hsa-miR-6125 gene" or "hsa-miR-6 The term "miR-6125" refers to the hsa-miR-6125 gene (miR-6125) set forth in SEQ ID NO: 253. RBase Accession No. MIMAT0024598) and other species The hsa-miR-6125 gene is a member of the Sm Ith JL et al., 2012, J Virol, vol. 86, p5278-5287 In addition, "hsa-miR-6125" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-6125) has a hairpin-like structure as a target gene. Session No. MI0021259, sequence number 592) is known.

[0329] As used herein, "hsa-miR-6126 gene" or "hsa-miR-6 The term "miR-6126" refers to the hsa-miR-6126 gene (miR-6126) set forth in SEQ ID NO: 254. RBase Accession No. MIMAT0024599) and other species The hsa-miR-6126 gene is a member of the Sm Ith JL et al., 2012, J Virol, vol. 86, p5278-5287 In addition, "hsa-miR-6126" can be obtained by the method described above. The miRBase Accession No. 1 (hsa-mir-6126) has a hairpin-like structure as a target protein. Session No. MI0021260, sequence number 593) is known.

[0330] As used herein, the term "hsa-miR-614 gene" or "hsa-miR-61 The term "miR-614" refers to the hsa-miR-614 gene (miRBa se Accession No. MIMAT0003282) and other species homologues or orthologues thereof. s JM et al., 2006, Proc Natl Acad Sci USA, 103 The method can be obtained by the method described in Vol. 2, pp. 3687-3692. -miR-614 has a hairpin-like structure as its precursor, hsa-mir-61 4" (miRBase Accession No. MI0003627, SEQ ID NO: 59 4) is known.

[0331] As used herein, "hsa-miR-615-5p gene" or "hsa-miR The term "miR-615-5p" refers to hsa-miR-615-5p as set forth in SEQ ID NO: 256. Gene (miRBase Accession No. MIMAT0004804) and Other species homologs or orthologs of hsa-miR-615-5 are also included. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci USA, Vol. 103, p3687-3692. In addition, the precursor of "hsa-miR-615-5p" has a hairpin-like structure. The structure of "hsa-mir-615" (miRBase Accession No. I0003628, sequence number 595) are known.

[0332] As used herein, "hsa-miR-619-5p gene" or "hsa-miR The term "miR-619-5p" refers to hsa-miR-619-5p as set forth in SEQ ID NO: 257. Gene (miRBase Accession No. MIMAT0026622) and Other species homologs or orthologs of hsa-miR-619-5 are also included. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci USA, Vol. 103, p3687-3692. In addition, the precursor of "hsa-miR-619-5p" has a hairpin-like structure. The structure of the miR-miR1 gene, hsa-mir-619 (miRBase Accession No. I0003633, sequence number 596) are known.

[0333] As used herein, the term "hsa-miR-638 gene" or "hsa-miR-63 The term "miR-638" refers to the hsa-miR-638 gene (miRBa se Accession No. MIMAT0003308) and other species homologues or orthologues thereof. The hsa-miR-638 gene is s JM et al., 2006, Proc Natl Acad Sci USA, 103 The method can be obtained by the method described in Vol. 2, pp. 3687-3692. -miR-638 has a hairpin-like structure as its precursor, hsa-mir-63 8" (miRBase Accession No. MI0003653, SEQ ID NO: 59 7) is known.

[0334] As used herein, the term "hsa-miR-642b-3p gene" or "hsa-mi The term "miR-642b-3p" refers to hsa-miR-642b as set forth in SEQ ID NO: 259. -3p gene (miRBase Accession No. MIMAT0018444 ) and other species homologs or orthologs. The 2b-3p gene is described in Witten D et al., 2010, BMC Biol, Vol. 8, p. 5. 8. Also, "hsa-miR-642b-3" can be obtained by the method described in p” is a precursor of “hsa-mir-642b” (miR Base Accession No. MI0016685, sequence number 598) is known. is.

[0335] As used herein, "hsa-miR-650 gene" or "hsa-miR-65 The term "miR-650" refers to the hsa-miR-650 gene (miRBa se Accession No. MIMAT0003320) and other species homologues or orthologues thereof. The hsa-miR-650 gene is s JM et al., 2006, Proc Natl Acad Sci U S A., 1 03, pp. 3687-3692. a-miR-650 has a hairpin-like structure as its precursor, hsa-mir-6 50" (miRBase Accession No. MI0003665, SEQ ID NO: 5 99) is known.

[0336] As used herein, "hsa-miR-663a gene" or "hsa-miR-6 The term "miR-663a" refers to the hsa-miR-663a gene (mi RBase Accession No. MIMAT0003326) and other species The hsa-miR-663a gene is a homologue or ortholog of the Cu mmins JM et al., 2006, Proc Natl Acad Sci USA It can be obtained by the method described in Vol. 103, pp. 3687-3692. "hsa-miR-663a" is a precursor of "hsa-m ir-663a” (miRBase Accession No. MI0003672, SEQ ID NO: 600) is known.

[0337] As used herein, "hsa-miR-663b gene" or "hsa-miR-6 The term "miR-663b" refers to the hsa-miR-663b gene set forth in SEQ ID NO: 262 (mi RBase Accession No. MIMAT0005867) and other species The hsa-miR-663b gene is a homologue or ortholog of the Ta Kada S et al., 2008, Leukemia, vol. 22, p1274-1278 In addition, "hsa-miR-663b" can be obtained by the method described above. The hairpin-like structure of the carrier, hsa-mir-663b (miRBase Ac cession No. MI0006336, sequence number 601) is known.

[0338] As used herein, the term "hsa-miR-6717-5p gene" or "hsa-mi The term "miR-6717-5p" refers to hsa-miR-6717 as set forth in SEQ ID NO: 263. -5p gene (miRBase Accession No. MIMAT0025846 ) and other species homologs or orthologs. The 17-5p gene is Li Y et al., 2012, Gene, vol. 497, p330-335. The miR-6717-5p antibody can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-6717" (miRB ase Accession No. MI0022551, sequence number 602) is known. There are.

[0339] As used herein, the term "hsa-miR-6721-5p gene" or "hsa-mi The term "miR-6721-5p" refers to hsa-miR-6721 as set forth in SEQ ID NO: 264. -5p gene (miRBase Accession No. MIMAT0025852 ) and other species homologs or orthologs. The 21-5p gene is Li Y et al., 2012, Gene, vol. 497, p330-335. The miR-6721-5p antibody can be obtained by the method described in the above. " has a hairpin-like structure as its precursor, "hsa-mir-6721" (miRB ase Accession No. MI0022556, sequence number 603) is known. There are.

[0340] As used herein, the term "hsa-miR-6726-5p gene" or "hsa-mi The term "miR-6726-5p" refers to hsa-miR-6726 as set forth in SEQ ID NO: 265. -5p gene (miRBase Accession No. MIMAT0027353 ) and other species homologs or orthologs. The 26-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6726-5p has a hairpin-like structure as its precursor, hsa-mi r-6726" (miRBase Accession No. MI0022571, Column number 604) is known.

[0341] As used herein, the term "hsa-miR-6727-5p gene" or "hsa-mi The term "miR-6727-5p" refers to hsa-miR-6727 as set forth in SEQ ID NO: 266. -5p gene (miRBase Accession No. MIMAT0027355 ) and other species homologs or orthologs. The 27-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6727-5p has a hairpin-like structure as its precursor, hsa-mi r-6727” (miRBase Accession No. MI0022572, Column number 605) is known.

[0342] As used herein, the term "hsa-miR-6738-5p gene" or "hsa-mi The term "miR-6738-5p" refers to hsa-miR-6738 as set forth in SEQ ID NO: 267. -5p gene (miRBase Accession No. MIMAT0027377 ) and other species homologs or orthologs. The 38-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6738-5p has a hairpin-like structure as its precursor, hsa-mi r-6738” (miRBase Accession No. MI0022583, Column number 606) is known.

[0343] As used herein, the term "hsa-miR-6741-5p gene" or "hsa-mi The term "miR-6741-5p" refers to hsa-miR-6741 as set forth in SEQ ID NO: 268. -5p gene (miRBase Accession No. MIMAT0027383 ) and other species homologs or orthologs. The 41-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6741-5p has a hairpin-like structure as its precursor, hsa-mi r-6741" (miRBase Accession No. MI0022586, Column number 607) is known.

[0344] As used herein, the term "hsa-miR-6749-5p gene" or "hsa-mi The term "miR-6749-5p" refers to hsa-miR-6749 as set forth in SEQ ID NO: 269. -5p gene (miRBase Accession No. MIMAT0027398 ) and other species homologs or orthologs. The 49-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6749-5p has a hairpin-like structure as its precursor, hsa-mi r-6749” (miRBase Accession No. MI0022594, Column number 608) is known.

[0345] As used herein, the term "hsa-miR-6752-5p gene" or "hsa-mi The term "miR-6752-5p" refers to hsa-miR-6752 as set forth in SEQ ID NO: 270. -5p gene (miRBase Accession No. MIMAT0027404 ) and other species homologs or orthologs. The 52-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6752-5p has a hairpin-like structure as its precursor, hsa-mi r-6752" (miRBase Accession No. MI0022597, Column number 609) is known.

[0346] As used herein, "hsa-miR-675-5p gene" or "hsa-miR The term "miR-675-5p" refers to hsa-miR-675-5p as set forth in SEQ ID NO: 271. Gene (miRBase Accession No. MIMAT0004284) and Other species homologs or orthologs of hsa-miR-675-5 are also included. The p gene is described in Cai X et al., 2007, RNA, vol. 13, p313-316. In addition, "hsa-miR-675-5p" can be obtained by the method described above. The hairpin-like structure of the marker “hsa-mir-675” (miRBase Acc Session No. MI0005416, sequence number 610) is known.

[0347] As used herein, the term "hsa-miR-6757-5p gene" or "hsa-mi The term "miR-6757-5p" refers to hsa-miR-6757 as set forth in SEQ ID NO: 272. -5p gene (miRBase Accession No. MIMAT0027414 ) and other species homologs or orthologs. The 57-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6757-5p has a hairpin-like structure as its precursor, hsa-mi r-6757” (miRBase Accession No. MI0022602, Column number 611) is known.

[0348] As used herein, the term "hsa-miR-6763-5p gene" or "hsa-mi The term "miR-6763-5p" refers to hsa-miR-6763 as set forth in SEQ ID NO: 273. -5p gene (miRBase Accession No. MIMAT0027426 ) and other species homologs or orthologs. The 63-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6763-5p has a hairpin-like structure as its precursor, hsa-mi r-6763” (miRBase Accession No. MI0022608, Column number 442) is known.

[0349] As used herein, the term "hsa-miR-6765-5p gene" or "hsa-mi The term "miR-6765-5p" refers to hsa-miR-6765 as set forth in SEQ ID NO: 274. -5p gene (miRBase Accession No. MIMAT0027430 ) and other species homologs or orthologs. The 65-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6765-5p has a hairpin-like structure as its precursor, hsa-mi r-6765” (miRBase Accession No. MI0022610, Column number 612) is known.

[0350] As used herein, the term "hsa-miR-6775-5p gene" or "hsa-mi The term "miR-6775-5p" refers to hsa-miR-6775 as set forth in SEQ ID NO: 275. -5p gene (miRBase Accession No. MIMAT0027450 ) and other species homologs or orthologs. The 75-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6775-5p has a hairpin-like structure as its precursor, hsa-mi r-6775" (miRBase Accession No. MI0022620, Column number 613) is known.

[0351] As used herein, the term "hsa-miR-6780b-5p gene" or "hsa-m The term "miR-6780b-5p" refers to hsa-miR-6780b-5p as set forth in SEQ ID NO: 276. 80b-5p gene (miRBase Accession No. MIMAT0027 572) and other species homologs or orthologs. The -6780b-5p gene was identified in Ladewig E et al., 2012, Genome Re It can be obtained by the method described in Vol. 22, pp. 1634-1645. "hsa-miR-6780b-5p" is a precursor of "hsa-miR-6780b-5p" which has a hairpin-like structure. sa-mir-6780b” (miRBase Accession No. MI002 2681, sequence number 614) is known.

[0352] As used herein, the term "hsa-miR-6782-5p gene" or "hsa-mi The term "miR-6782-5p" refers to hsa-miR-6782 as set forth in SEQ ID NO: 277. -5p gene (miRBase Accession No. MIMAT0027464 ) and other species homologs or orthologs. The 82-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6782-5p has a hairpin-like structure as its precursor, hsa-mi r-6782” (miRBase Accession No. MI0022627, Column number 615) is known.

[0353] As used herein, the term "hsa-miR-6784-5p gene" or "hsa-mi The term "miR-6784-5p" refers to hsa-miR-6784 as set forth in SEQ ID NO: 278. -5p gene (miRBase Accession No. MIMAT0027468 ) and other species homologs or orthologs. The 84-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6784-5p has a hairpin-like structure as its precursor, hsa-mi r-6784" (miRBase Accession No. MI0022629, Column number 616) is known.

[0354] As used herein, the term "hsa-miR-6800-5p gene" or "hsa-mi The term "miR-6800-5p" refers to the hsa-miR-6800 -5p gene (miRBase Accession No. MIMAT0027500 ) and other species homologs or orthologs. The 00-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6800-5p has a hairpin-like structure as its precursor, hsa-mi r-6800” (miRBase Accession No. MI0022645, Column number 451) is known.

[0355] As used herein, the term "hsa-miR-6806-5p gene" or "hsa-mi The term "miR-6806-5p" refers to hsa-miR-6806 as set forth in SEQ ID NO: 280. -5p gene (miRBase Accession No. MIMAT0027512 ) and other species homologs or orthologs. The 06-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6806-5p has a hairpin-like structure as its precursor, hsa-mi r-6806" (miRBase Accession No. MI0022651, Column number 617) is known.

[0356] As used herein, the term "hsa-miR-6840-3p gene" or "hsa-mi The term "miR-6840-3p" refers to the hsa-miR-6840 -3p gene (miRBase Accession No. MIMAT0027583 ) and other species homologs or orthologs. The 40-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6840-3p has a hairpin-like structure as its precursor, hsa-mi r-6840" (miRBase Accession No. MI0022686, Column number 618) is known.

[0357] As used herein, the term "hsa-miR-6848-5p gene" or "hsa-mi The term "miR-6848-5p" refers to hsa-miR-6848 as set forth in SEQ ID NO: 282. -5p gene (miRBase Accession No. MIMAT0027596 ) and other species homologs or orthologs. The 48-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6848-5p has a hairpin-like structure as its precursor, hsa-mi r-6848” (miRBase Accession No. MI0022694, Column number 619) is known.

[0358] As used herein, the term "hsa-miR-6851-5p gene" or "hsa-mi The term "miR-6851-5p" refers to hsa-miR-6851 as set forth in SEQ ID NO: 283. -5p gene (miRBase Accession No. MIMAT0027602 ) and other species homologs or orthologs. The 51-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6851-5p has a hairpin-like structure as its precursor, hsa-mi r-6851" (miRBase Accession No. MI0022697, Column number 620) is known.

[0359] As used herein, the term "hsa-miR-6870-5p gene" or "hsa-mi The term "miR-6870-5p" refers to the hsa-miR-6870 -5p gene (miRBase Accession No. MIMAT0027640 ) and other species homologs or orthologs. The 70-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6870-5p has a hairpin-like structure as its precursor, hsa-mi r-6870” (miRBase Accession No. MI0022717, Column number 621) is known.

[0360] As used herein, the term "hsa-miR-6872-3p gene" or "hsa-mi The term "miR-6872-3p" refers to hsa-miR-6872 as set forth in SEQ ID NO: 285. -3p gene (miRBase Accession No. MIMAT0027645 ) and other species homologs or orthologs. The 72-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6872-3p has a hairpin-like structure as its precursor, hsa-mi r-6872” (miRBase Accession No. MI0022719, Column number 622) is known.

[0361] As used herein, the term "hsa-miR-6875-5p gene" or "hsa-mi The term "miR-6875-5p" refers to hsa-miR-6875 as set forth in SEQ ID NO: 286. -5p gene (miRBase Accession No. MIMAT0027650 ) and other species homologs or orthologs. The 75-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6875-5p has a hairpin-like structure as its precursor, hsa-mi r-6875” (miRBase Accession No. MI0022722, Column number 623) is known.

[0362] As used herein, the term "hsa-miR-6877-5p gene" or "hsa-mi The term "miR-6877-5p" refers to hsa-miR-6877 as set forth in SEQ ID NO: 287. -5p gene (miRBase Accession No. MIMAT0027654 ) and other species homologs or orthologs. The 77-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6877-5p has a hairpin-like structure as its precursor, hsa-mi r-6877” (miRBase Accession No. MI0022724, Column number 624) is known.

[0363] As used herein, the term "hsa-miR-6879-5p gene" or "hsa-mi The term "miR-6879-5p" refers to hsa-miR-6879 as set forth in SEQ ID NO: 288. -5p gene (miRBase Accession No. MIMAT0027658 ) and other species homologs or orthologs. The 79-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6879-5p has a hairpin-like structure as its precursor, hsa-mi r-6879” (miRBase Accession No. MI0022726, Column number 625) is known.

[0364] As used herein, the term "hsa-miR-6880-5p gene" or "hsa-mi The term "miR-6880-5p" refers to the hsa-miR-6880 -5p gene (miRBase Accession No. MIMAT0027660 ) and other species homologs or orthologs. The 80-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6880-5p has a hairpin-like structure as its precursor, hsa-mi r-6880” (miRBase Accession No. MI0022727, Column number 464) is known.

[0365] As used herein, the term "hsa-miR-6885-5p gene" or "hsa-mi The term "miR-6885-5p" refers to hsa-miR-6885 as set forth in SEQ ID NO: 290. -5p gene (miRBase Accession No. MIMAT0027670 ) and other species homologs or orthologs. The 85-5p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6885-5p has a hairpin-like structure as its precursor, hsa-mi r-6885" (miRBase Accession No. MI0022732, Column number 626) is known.

[0366] As used herein, the term "hsa-miR-6887-5p gene" or "hsa-mi The term "miR-6887-5p" refers to hsa-miR-6887 as set forth in SEQ ID NO: 291. -5p gene (miRBase Accession No. MIMAT0027674 ) and other species homologs or orthologs. The 87-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6887-5p has a hairpin-like structure as its precursor, hsa-mi r-6887" (miRBase Accession No. MI0022734, Column number 627) is known.

[0367] As used herein, the term "hsa-miR-7108-5p gene" or "hsa-mi The term "miR-7108-5p" refers to hsa-miR-7108 as set forth in SEQ ID NO: 292. -5p gene (miRBase Accession No. MIMAT0028113 ) and other species homologs or orthologs. The 08-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7108-5p has a hairpin-like structure as its precursor, hsa-mi r-7108” (miRBase Accession No. MI0022959, Column number 495) is known.

[0368] As used herein, "hsa-miR-711 gene" or "hsa-miR-71 The term "miR-711" refers to the hsa-miR-711 gene (miRBa se Accession No. MIMAT0012734) and other species homologues or orthologues thereof. The hsa-miR-711 gene is S et al., 2008, BMC Bioinformatics, Vol. 9, p. 39 The precursor of "hsa-miR-711" can be obtained by the method described above. The hairpin-like structure of "hsa-mir-711" (miRBase Accession No. on No. MI0012488, sequence number 628) is known.

[0369] As used herein, the term "hsa-miR-7113-3p gene" or "hsa-mi The term "miR-7113-3p" refers to hsa-miR-7113 as set forth in SEQ ID NO: 294. -3p gene (miRBase Accession No. MIMAT0028124 ) and other species homologs or orthologs. The 13-3p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-7113-3p has a hairpin-like structure as its precursor, hsa-mi r-7113" (miRBase Accession No. MI0022964, Column number 629) is known.

[0370] As used herein, "hsa-miR-744-5p gene" or "hsa-miR The term "miR-744-5p" refers to hsa-miR-744-5p as set forth in SEQ ID NO: 295. Gene (miRBase Accession No. MIMAT0004945) and Other species homologs or orthologs of hsa-miR-744-5 are also included. The p gene is described in Berezikov E et al., 2006, Genome Res, vol. 16, It can be obtained by the method described on pages 1289-1298 of the "HSA-M iR-744-5p is a precursor of hsa-mir-7, which has a hairpin-like structure. 44" (miRBase Accession No. MI0005559, SEQ ID NO: 6 30) is known.

[0371] As used herein, "hsa-miR-760 gene" or "hsa-miR-76 The term "miR-760" refers to the hsa-miR-760 gene (miRBa se Accession No. MIMAT0004957) and other species homologues or orthologues thereof. kov E et al., 2006, Genome Res, vol. 16, p1289-1298 The hsa-miR-760 can be obtained by the method described in the literature. The hairpin-like structure of the marker “hsa-mir-760” (miRBase Acc Session No. MI0005567, sequence number 631) is known.

[0372] As used herein, the term "hsa-miR-7845-5p gene" or "hsa-mi The term "miR-7845-5p" refers to hsa-miR-7845 as set forth in SEQ ID NO: 297. -5p gene (miRBase Accession No. MIMAT0030420 ) and other species homologs or orthologs. The 45-5p gene is Ple H et al., 2012, PLoS One, vol. 7, e5074 6. Also, "hsa-miR-7845-5 p” has a hairpin-like structure as its precursor “hsa-mir-7845” (miR Base Accession No. MI0025515, sequence number 632) is known. is.

[0373] As used herein, the term "hsa-miR-7847-3p gene" or "hsa-mi The term "miR-7847-3p" refers to hsa-miR-7847 as set forth in SEQ ID NO: 298. -3p gene (miRBase Accession No. MIMAT0030422 ) and other species homologs or orthologs. The 47-3p gene is Ple H et al., 2012, PLoS One, vol. 7, e5074 6. Also, "hsa-miR-7847-3 p” has a hairpin-like structure as its precursor “hsa-mir-7847” (miR Base Accession No. MI0025517, sequence number 633) is known. is.

[0374] As used herein, "hsa-miR-7977 gene" or "hsa-miR-7 The term "miR-7977" refers to the hsa-miR-7977 gene set forth in SEQ ID NO: 299 (mi RBase Accession No. MIMAT0031180) and other species The hsa-miR-7977 gene is a member of the Ve lthut-Meikas A et al., 2013, Mol Endocrinol, Online The miR-797 can be obtained by the method described in the online publication. 7” has a hairpin-like structure as its precursor “hsa-mir-7977” (miR Base Accession No. MI0025753, sequence number 634) is known. is.

[0375] As used herein, "hsa-miR-8059 gene" or "hsa-miR-8 The term "miR-8059" refers to the hsa-miR-8059 gene (miR-8059) set forth in SEQ ID NO: 300. RBase Accession No. MIMAT0030986) and other species The hsa-miR-8059 gene is a member of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8059" can be obtained as a precursor of hsa-miR-8059. The apin-like structure of "hsa-mir-8059" (miRBase Accession n No. MI0025895, sequence number 635) is known.

[0376] As used herein, "hsa-miR-8063 gene" or "hsa-miR-8 The term "miR-8063" refers to the hsa-miR-8063 gene (miR-8063) set forth in SEQ ID NO: 301. RBase Accession No. MIMAT0030990) and other species The hsa-miR-8063 gene is a homologue or ortholog of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8063" can be obtained as a precursor of hsa-miR-8063. The apin-like structure of "hsa-mir-8063" (miRBase Accession No. n No. MI0025899, sequence number 636) is known.

[0377] As used herein, "hsa-miR-8072 gene" or "hsa-miR-8 The term "miR-8072" refers to the hsa-miR-8072 gene (miR-8072) set forth in SEQ ID NO: 302. RBase Accession No. MIMAT0030999) and other species The hsa-miR-8072 gene is a homologue or ortholog of the Wa According to the method described in ng HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8072" can be obtained as a precursor of hsa-miR-8072. The apin-like structure of "hsa-mir-8072" (miRBase Accession No. n No. MI0025908, sequence number 637) is known.

[0378] As used herein, "hsa-miR-874-3p gene" or "hsa-miR The term "miR-874-3p" refers to hsa-miR-874-3p as set forth in SEQ ID NO: 303. Gene (miRBase Accession No. MIMAT0004911) and Other species homologs or orthologs of hsa-miR-874-3 are also included. p gene, Landgraf P et al., 2007, Cell., vol. 129, p140 The hsa-miR-8 can be obtained by the method described in 74-3p" has a hairpin-like structure as its precursor "hsa-mir-874" ( miRBase Accession No. MI0005532, sequence number 475) It is known.

[0379] As used herein, the term "hsa-miR-92a-2-5p gene" or "hsa-miR-92a-2-5p gene" refers to The term "miR-92a-2-5p" refers to the hsa-miR-92 a-2-5p gene (miRBase Accession No. MIMAT0004 508) and other species homologs or orthologs. The -92a-2-5p gene was identified in Mourelatos Z et al., 2002, Genes Dev, vol. 16, pp. 720-728. "hsa-miR-92a-2-5p" is a precursor of "hsa-miR-92a-2-5p" which has a hairpin-like structure. sa-mir-92a-2” (miRBase Accession No. MI000 0094, SEQ ID NO: 638) is known.

[0380] As used herein, "hsa-miR-92b-5p gene" or "hsa-miR The term "miR-92b-5p" refers to hsa-miR-92b-5p as set forth in SEQ ID NO: 305. Gene (miRBase Accession No. MIMAT0004792) and Other species homologs or orthologs of hsa-miR-92b-5 are also included. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci USA, Vol. 103, p3687-3692. In addition, the precursor of "hsa-miR-92b-5p" has a hairpin-like structure. The structure of "hsa-mir-92b" (miRBase Accession No. I0003560, sequence number 499) is known.

[0381] As used herein, "hsa-miR-940 gene" or "hsa-miR-94 The term "miR-940" refers to the hsa-miR-940 gene (miRBa se Accession No. MIMAT0004983) and other species homologues or orthologues thereof. The hsa-miR-940 gene was The method described in Cancer Res, vol. 67, pp. 6031-6043, 2007. The precursor of hsa-miR-940 is The hairpin-like structure of "hsa-mir-940" (miRBase Accession No. n No. MI0005762, sequence number 639) is known.

[0382] As used herein, the term "hsa-miR-1228-3p gene" or "hsa-mi The term "miR-1228-3p" refers to hsa-miR-1228 as set forth in SEQ ID NO: 307. -3p gene (miRBase Accession No. MIMAT0005583 ) and other species homologs or orthologs. The 28-3p gene is described in Berezikov E et al., 2007, Mol Cell, 28 The method can be obtained by the method described in Vol. 1, pp. 328-336. iR-1228-3p is a precursor of the hairpin-like structure known as hsa-mir- 1228" (miRBase Accession No. MI0006318, sequence no. No. 511) is known.

[0383] As used herein, "hsa-miR-1275 gene" or "hsa-miR-1 The term "miR-1275" refers to the hsa-miR-1275 gene (miR-1275) set forth in SEQ ID NO: 308. RBase Accession No. MIMAT0005929) and other species The hsa-miR-1275 gene is a member of the Mo Rin RD et al., 2008, Genome Res, vol. 18, p610-621 In addition, "hsa-miR-1275" can be obtained by the method described above. The hairpin-like structure of the carrier, “hsa-mir-1275” (miRBase Ac Accession No. MI0006415, SEQ ID NO: 640) is known.

[0384] As used herein, the term "hsa-miR-1307-3p gene" or "hsa-mi The term "miR-1307-3p" refers to hsa-miR-1307 as set forth in SEQ ID NO: 309. -3p gene (miRBase Accession No. MIMAT0005951 ) and other species homologs or orthologs. The 07-3p gene is described in Morin RD et al., 2008, Genome Res, vol. 18. The hsa-mi can be obtained by the method described in the above. R-1307-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 307" (miRBase Accession No. MI0006444, SEQ ID NO: 641) is known.

[0385] As used herein, the term "hsa-miR-1343-5p gene" or "hsa-mi The term "miR-1343-5p" refers to hsa-miR-1343 as set forth in SEQ ID NO: 310. -5p gene (miRBase Accession No. MIMAT0027038 ) and other species homologs or orthologs. The 43-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -1343-5p is a precursor of hsa-mir-13, which has a hairpin-like structure. 43" (miRBase Accession No. MI0017320, SEQ ID NO: 5 00) is known.

[0386] As used herein, "hsa-miR-23a-3p gene" or "hsa-miR The term "miR-23a-3p" refers to hsa-miR-23a-3p as set forth in SEQ ID NO: 311. Gene (miRBase Accession No. MIMAT0000078) and Other species homologs or orthologs of hsa-miR-23a-3 are also included. The p gene is described in Lagos-Quintana M et al., 2001, Science, 29 It can be obtained by the method described in Vol. 4, p. 853-858. miR-23a-3p is a precursor of the hairpin-like structure called "hsa-mir- 23a" (miRBase Accession No. MI0000079, SEQ ID NO: 642) is known.

[0387] As used herein, "hsa-miR-29b-3p gene" or "hsa-miR The term "miR-29b-3p" refers to hsa-miR-29b-3p as set forth in SEQ ID NO: 312. Gene (miRBase Accession No. MIMAT0000100) and Other species homologs or orthologs of hsa-miR-29b-3 are also included. The p gene was described in Mourelatos Z et al., 2002, Genes Dev., 16 The HSA-M iR-29b-3p is a precursor of hsa-mir-2, which has a hairpin-like structure. 9b-1, hsa-mir-29b-2” (miRBase Accession No. .MI0000105, MI0000107, sequence numbers 643 and 644) are known .

[0388] As used herein, "hsa-miR-3135b gene" or "hsa-miR- The term "miR-3135b" refers to the hsa-miR-3135b gene set forth in SEQ ID NO: 313. (miRBase Accession No. MIMAT0018985) and other Species homologs or orthologs are included. hsa-miR-3135b gene Jima DD et al., 2010, Blood, vol. 116, e118-e127 In addition, "hsa-miR-3135b" can be obtained by the method described above. The precursor of "hsa-mir-3135b" (miRBase Accession No. MI0016809, SEQ ID NO: 645) is known.

[0389] As used herein, the term "hsa-miR-3185 gene" or "hsa-miR-3 The term "miR-3185" refers to the hsa-miR-3185 gene set forth in SEQ ID NO: 314 (mi RBase Accession No. MIMAT0015065) and other species The hsa-miR-3185 gene is a member of the St Ark MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3185" can be obtained as a precursor of hsa-miR-3185. The miRBase Accession No. 1 (hsa-mir-3185), which has an apin-like structure, n No. MI0014227, sequence number 646) is known.

[0390] As used herein, "hsa-miR-4532 gene" or "hsa-miR-4 The term "miR-4532" refers to the hsa-miR-4532 gene (mi RBase Accession No. MIMAT0019071) and other species The hsa-miR-4532 gene is a homologue or ortholog of the Ji The person described in Ma DD et al., 2010, Blood, Vol. 116, e118-e127 The precursor of hsa-miR-4532 is The hairpin-like structure of “hsa-mir-4532” (miRBase Accession No. ion No. MI0016899, sequence number 647) is known.

[0391] As used herein, the term "hsa-miR-4690-5p gene" or "hsa-mi The term "miR-4690-5p" refers to the hsa-miR-4690 -5p gene (miRBase Accession No. MIMAT0019779 ) and other species homologs or orthologs. The 90-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4690-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 90" (miRBase Accession No. MI0017323, SEQ ID NO: 6 48) is known.

[0392] As used herein, the term "hsa-miR-4758-5p gene" or "hsa-mi The term "miR-4758-5p" refers to hsa-miR-4758 as set forth in SEQ ID NO: 317. -5p gene (miRBase Accession No. MIMAT0019903 ) and other species homologs or orthologs. The 58-5p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4758-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 58" (miRBase Accession No. MI0017399, SEQ ID NO: 6 49) is known.

[0393] As used herein, the term "hsa-miR-4783-3p gene" or "hsa-mi The term "miR-4783-3p" refers to hsa-miR-4783 as set forth in SEQ ID NO: 318. -3p gene (miRBase Accession No. MIMAT0019947 ) and other species homologs or orthologs. The 83-3p gene is described in Persson H et al., 2011, Cancer Res, 71 The hsa-miR -4783-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 83" (miRBase Accession No. MI0017428, SEQ ID NO: 6 50) is known.

[0394] As used herein, "hsa-miR-6131 gene" or "hsa-miR-6 The term "miR-6131" refers to the hsa-miR-6131 gene (miR-6131) set forth in SEQ ID NO: 319. RBase Accession No. MIMAT0024615) and other species The hsa-miR-6131 gene is a homologue or ortholog. Nnemann M et al., 2012, Genome Biol Evol, vol. 4, p. 55 The hsa-miR-61 can be obtained by the method described in 31" has a hairpin-like structure as its precursor, "hsa-mir-6131" (mi RBase Accession No. MI0021276, sequence number 651) is known. It is being done.

[0395] As used herein, "hsa-miR-625-3p gene" or "hsa-miR The term "miR-625-3p" refers to hsa-miR-625-3p as set forth in SEQ ID NO: 320. Gene (miRBase Accession No. MIMAT0004808) and Other species homologs or orthologs of hsa-miR-625-3 are also included. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci USA, Vol. 103, p3687-3692. In addition, the precursor of "hsa-miR-625-3p" has a hairpin-like structure. The miRBase Accession No. I0003639, sequence number 652) is known.

[0396] As used herein, "hsa-miR-6511a-5p gene" or "hsa-m The term "miR-6511a-5p" refers to hsa-miR-65 11a-5p gene (miRBase Accession No. MIMAT0025 478) and other species homologs or orthologs. The -6511a-5p gene was identified in Joyce CE et al., 2011, Hum Mol Ge It can be obtained by the method described in vol. 20, pp. 4025-4040. In addition, "hsa-miR-6511a-5p" has a hairpin-like structure as its precursor. "hsa-mir-6511a-1, hsa-mir-6511a-2, hsa-mir -6511a-3, hsa-mir-6511a-4” (miRBase Access ion No. MI0022223, MI0023564, MI0023565, MI0 023566, sequence numbers 653, 654, 655, and 656) are known.

[0397] As used herein, the term "hsa-miR-6765-3p gene" or "hsa-mi The term "miR-6765-3p" refers to hsa-miR-6765 as set forth in SEQ ID NO: 322. -3p gene (miRBase Accession No. MIMAT0027431 ) and other species homologs or orthologs. The 65-3p gene is Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6765-3p has a hairpin-like structure as its precursor, hsa-mi r-6765” (miRBase Accession No. MI0022610, Column number 612) is known.

[0398] As used herein, the term "hsa-miR-6816-5p gene" or "hsa-mi The term "miR-6816-5p" refers to hsa-miR-6816 as set forth in SEQ ID NO: 323. -5p gene (miRBase Accession No. MIMAT0027532 ) and other species homologs or orthologs. The 16-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6816-5p has a hairpin-like structure as its precursor, hsa-mi r-6816" (miRBase Accession No. MI0022661, Column number 657) is known.

[0399] As used herein, the term "hsa-miR-6825-5p gene" or "hsa-mi The term "miR-6825-5p" refers to the hsa-miR-6825 -5p gene (miRBase Accession No. MIMAT0027550 ) and other species homologs or orthologs. The 25-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6825-5p has a hairpin-like structure as its precursor, hsa-mi r-6825" (miRBase Accession No. MI0022670, Column number 658) is known.

[0400] As used herein, the term "hsa-miR-6845-5p gene" or "hsa-mi The term "miR-6845-5p" refers to hsa-miR-6845 as set forth in SEQ ID NO: 325. -5p gene (miRBase Accession No. MIMAT0027590 ) and other species homologs or orthologs. The 45-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 The method can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6845-5p has a hairpin-like structure as its precursor, hsa-mi r-6845" (miRBase Accession No. MI0022691, Column number 659) is known.

[0401] As used herein, "hsa-miR-7150 gene" or "hsa-miR-7 The term "miR-7150" refers to the hsa-miR-7150 gene (miR-7150) set forth in SEQ ID NO: 326. RBase Accession No. MIMAT0028211) and other species The hsa-miR-7150 gene is a homologue or ortholog. Las A et al., 2009, Nucleic Acids Res, Vol. 37, p. 3276 The miR-71 can be obtained by the method described in US Pat. 50" has a hairpin-like structure as its precursor "hsa-mir-7150" (mi RBase Accession No. MI0023610, sequence number 660) is known. It is being done.

[0402] As used herein, "hsa-miR-7641 gene" or "hsa-miR-7 The term "miR-7641" refers to the hsa-miR-7641 gene (mi RBase Accession No. MIMAT0029782) and other species The hsa-miR-7641 gene is a member of the Yo o JK et al., 2013, Arch Pharm Res, vol. 36, p. 353-358 The hsa-miR-7641 can be obtained by the method described in The hairpin-like structure of the precursor of hsa-mir-7641-1 and hsa-mir -7641-2” (miRBase Accession No. MI0024975, MI0024976, SEQ ID NOs: 661, 662) are known.

[0403] As used herein, "hsa-miR-7975 gene" or "hsa-miR-7 The term "miR-7975" refers to the hsa-miR-7975 gene (miR-7975) set forth in SEQ ID NO: 328. RBase Accession No. MIMAT0031178) and other species The hsa-miR-7975 gene is a member of the Ve lthut-Meikas A et al., 2013, Mol Endocrinol, Online The miR-797 can be obtained by the method described in the online publication. miR 5 has a hairpin-like structure as its precursor, hsa-mir-7975 (miR Base Accession No. MI0025751, sequence number 663) is known. is.

[0404] As used herein, "hsa-miR-92a-3p gene" or "hsa-miR The term "miR-92a-3p" refers to hsa-miR-92a-3p as set forth in SEQ ID NO: 329. Gene (miRBase Accession No. MIMAT0000092) and Other species homologs or orthologs of hsa-miR-92a-3 are also included. The p gene is described in Mourelatos Z et al., 2002, Genes Dev, vol. 16, The hsa-miR -92a-3p is a precursor of hsa-mir-92a, which has a hairpin-like structure. -1, hsa-mir-92a-2” (miRBase Accession No.M I0000093, MI0000094, sequence numbers 664 and 638) are known.

[0405] In addition, mature miRNAs are derived from RNA precursors with hairpin-like structures. When A is excised, one or several bases before and after the sequence may be cut shorter or longer. Base substitutions can occur, resulting in mutants, called isomiRs (Morin R D. et al., 2008, Genome Res., Vol. 18, p. 610-621). In RBase Release 21, the base sequence represented by any of SEQ ID NOs: 1 to 329 In addition to the sequence, there are a number of isomiRs, each of which has a sequence number between 665 and 1000. The variants and fragments of the nucleotide sequences that can be used are also shown. These variants are also shown in SEQ ID NOs: 1 to 3. The miRNA can be obtained by using any one of the following nucleotide sequences: SEQ ID NOs: 4, 7, 8, 9, 13, 14, 18, 20, 21, 22, 23, 26, 2 8, 31, 32, 33, 35, 36, 38, 41, 44, 45, 46, 48, 49, 51 , 52, 53, 54, 55, 56, 57, 58, 61, 62, 68, 73, 74, 77, 78, 82, 83, 84, 85, 86, 87, 91, 92, 93, 94, 95, 96, 9 7, 100, 101, 138, 139, 141, 145, 146, 147, 150, 15 1, 163, 164, 167, 170, 171, 175, 177, 179, 180, 18 1, 182, 183, 184, 185, 188, 189, 190, 191, 192, 19 3, 195, 196, 197, 198, 200, 201, 202, 203, 204, 20 6, 207, 209, 210, 211, 212, 214, 216, 220, 223, 22 4, 226, 227, 229, 230, 231, 233, 235, 237, 240, 24 1, 244, 245, 246, 249, 252, 253, 254, 256, 257, 25 8, 259, 260, 261, 262, 263, 264, 295, 296, 303, 30 4, 305, 306, 307, 308, 309, 311, 312, 313, 315, 31 6, 317, 318, 319, 320, 321, 329 or a salt thereof Among the variants of polynucleotides consisting of a base sequence in which u is replaced by t, e.g. The longest variants registered in miRBase Release 21 are SEQ ID NOs: 666, 668, 669, 671, 674, 676, 679, 681, 683 , 685, 687, 691, 693, 697, 699, 701, 703, 705, 707 , 709, 712, 713, 715, 717, 719, 721, 723, 724, 726 , 728, 730, 732, 734, 736, 738, 743, 748, 750, 752 , 754, 757, 759, 761, 763, 765, 767, 770, 772, 774 , 776, 778, 779, 781, 783, 785, 787, 789, 792, 795 , 797, 799, 803, 805, 808, 810, 812, 815, 817, 819 , 821, 824, 826, 828, 830, 832, 834, 836, 840, 842 , 844, 846, 848, 850, 853, 855, 857, 859, 862, 864 , 866, 868, 870, 873, 875, 877, 879, 881, 883, 886 , 889, 892, 896, 898, 901, 903, 904, 906, 908, 911 , 912, 914, 917, 919, 923, 925, 927, 930, 933, 935 , 937, 940, 942, 944, 946, 948, 950, 952, 954, 956 , 960, 962, 964, 966, 968, 970, 972, 974, 976, 978 , 980, 982, 985, 987, 989, 991, 993, 994, 996, 999 The polynucleotides represented by SEQ ID NOs: 3, 4, 8, 9, 1 and 2 of the present invention are also included. 0, 13, 14, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28, 29 , 30, 31, 32, 33, 35, 36, 38, 41, 43, 45, 46, 48, 49, 51, 53, 54, 55, 56, 57, 58, 61, 62, 65, 66, 67, 68, 6 9, 71, 72, 73, 74, 77, 78, 80, 82, 83, 84, 85, 86, 87 , 89, 91, 92, 93, 94, 96, 97, 100, 114, 138, 139, 14 0, 141, 142, 145, 146, 147, 148, 149, 150, 151, 16 2, 163, 164, 167, 168, 170, 171, 175, 177, 178, 17 9, 180, 181, 182, 183, 184, 185, 186, 187, 188, 18 9, 190, 191, 192, 193, 194, 195, 196, 197, 198, 19 9, 200, 201, 202, 203, 204, 205, 206, 207, 209, 21 0, 211, 212, 213, 214, 215, 216, 219, 220, 221, 22 2, 223, 224, 225, 226, 229, 230, 231, 232, 235, 23 7, 238, 240, 241, 242, 243, 244, 245, 246, 248, 24 9, 251, 252, 253, 254, 255, 256, 257, 258, 259, 26 0, 261, 262, 263, 264, 271, 293, 295, 296, 303, 30 4, 305, 306, 307, 308, 309, 311, 312, 313, 314, 31 If the base sequence represented by 5, 316, 317, 318, 320, 321, 328, or 329 is or a variant of said polynucleotide having a base sequence in which u is t. For example, the shortest variant registered in miRBase Release 21 is and SEQ ID NOs: 665, 667, 670, 672, 673, 675, 677, and 67 8, 680, 682, 684, 686, 688, 689, 690, 692, 694, 69 5, 696, 698, 700, 702, 704, 706, 708, 710, 711, 71 4, 716, 718, 720, 722, 725, 727, 729, 731, 733, 73 5, 737, 739, 740, 741, 742, 744, 745, 746, 747, 74 9, 751, 753, 755, 756, 758, 760, 762, 764, 766, 76 8, 769, 771, 773, 775, 777, 780, 782, 784, 786, 78 8, 790, 791, 793, 794, 796, 798, 800, 801, 802, 80 4, 806, 807, 809, 811, 813, 814, 816, 818, 820, 82 2, 823, 825, 827, 829, 831, 833, 835, 837, 838, 83 9, 841, 843, 845, 847, 849, 851, 852, 854, 856, 85 8, 860, 861, 863, 865, 867, 869, 871, 872, 874, 87 6, 878, 880, 882, 884, 885, 887, 888, 890, 891, 89 3, 894, 895, 897, 899, 900, 902, 905, 907, 909, 91 0, 913, 915, 916, 918, 920, 921, 922, 924, 926, 92 8, 929, 931, 932, 934, 936, 938, 939, 941, 943, 94 5, 947, 949, 951, 953, 955, 957, 958, 959, 961, 96 3, 965, 967, 969, 971, 973, 975, 977, 979, 981, 98 3, 984, 986, 988, 990, 992, 995, 997, 998, 1000 In addition to these variants and fragments, the following polynucleotides are also included: Polynucleotides, which are a number of isomiRs with SEQ ID NOs: 1 to 329 registered in miRBase Furthermore, a nucleic acid sequence comprising any one of the base sequences represented by SEQ ID NOs: 1 to 329 can be used. Examples of polynucleotides that include the above-mentioned sequences include the precursor sequences of SEQ ID NOs: 330 to 664. The polynucleotides represented by the above formula (1) are examples of the polynucleotides represented by the above formula (1).

[0406] Names of genes represented by SEQ ID NOs: 1 to 1000 and miRBase Accession Nos. The registration numbers are listed in Table 1.

[0407] As used herein, the term "capable of specifically binding" refers to a nucleic acid probe or a probe used in the present invention. A nucleic acid such as a primer binds to a specific target nucleic acid and cannot substantially bind to other nucleic acids. means...

[0408] [Table 1] TIFF2025000928000002.tif249122 TIFF2025000928000003.tif250125 TIFF2025000928000004.tif251121 TIFF2025000928000005.tif251122 TIFF2025000928000006.tif252123 TIFF2025000928000007.tif250121 TIFF2025000928000008.tif250122 TIFF2025000928000009.tif249125 TIFF2025000928000010.tif251121 TIFF2025000928000011.tif249123 TIFF2025000928000012.tif250122 TIFF2025000928000013.tif249120 TIFF2025000928000014.tif250121 TIFF2025000928000015.tif249120 TIFF2025000928000016.tif249123 TIFF2025000928000017.tif250121 TIFF2025000928000018.tif250125 TIFF2025000928000019.tif249123 TIFF2025000928000020.tif249123 TIFF2025000928000021.tif129127 Effect of the Invention

[0409] According to the present invention, it is possible to easily and accurately detect lung cancer. For example, The expression of one or several miRNAs in the blood, serum and / or plasma of a patient can be minimally invasively collected. By using the measured amount of the cancer as an indicator, it is possible to easily detect whether or not a patient has lung cancer.

[0410] This specification incorporates the disclosures of Japanese Patent Application No. 2017-126933, which is the priority basis of this application. Includes. [Brief description of the drawings]

[0411] [Figure 1] This figure shows the relationship between the base sequences of hsa-miR-4433a-5p, represented by sequence number 142, which is generated from its precursor hsa-mir-4433a, represented by sequence number 382, ​​and hsa-miR-4433a-3p, represented by sequence number 46. [Diagram 2]Upper figure: hsa-miR-1343-3p (SEQ ID NO: 164), hsa-miR-197-5p (SEQ ID NO: 18), hsa-miR-6741-5p (SEQ ID NO: 268), hsa-miR-4687-3p (SEQ ID NO: 147), and hsa in the serum of subjects not suffering from lung cancer (1233 healthy subjects, 263 patients with benign bone and soft tissue tumors and benign breast diseases, and 1281 patients with cancer other than lung cancer, totaling 2777 subjects) and lung cancer patients (1186 subjects) selected as the learning sample group. A discriminant equation was created using Fisher's discriminant analysis from the measured values ​​of the expression level of -miR-1268b (SEQ ID NO: 184) (0.960xhsa-miR-1343-3p-0.703xhsa-miR-197-5p-0.184xhsa-miR-6741-5p+0.506xhsa-miR-4687-3p-0.471xhsa-miR-1268b-1.273), and the discriminant score obtained from the discriminant equation is shown on the vertical axis, and the sample group is shown on the horizontal axis. In addition, in consideration of the ease of viewing the figure, 400 subjects each were randomly extracted from subjects who were not affected by lung cancer and lung cancer patients, and the discriminant scores were illustrated. The dotted line in the figure indicates the discriminant boundary for discriminating between the two groups with a discriminant score of 0. The figure below shows the serum levels of hsa-miR-1343-3p (SEQ ID NO: 164), hsa-miR-197-5p (SEQ ID NO: 18), hsa-miR-6741-5p (SEQ ID NO: 268), and hsa-miR-4687-3p (SEQ ID NO: 147) in subjects without lung cancer (567 healthy subjects, 105 patients with benign bone and soft tissue tumors and benign breast diseases, and 519 patients with cancer other than lung cancer, for a total of 1,191 subjects) and lung cancer patients (508 subjects) selected as the validation sample group. The measured values ​​of the expression levels of hsa-miR-1268b (SEQ ID NO: 184) and hsa-miR-1343-3p-0.703xhsa-miR-197-5p-0.184xhsa-miR-6741-5p+0.506xhsa-miR-4687-3p-0.471xhsa-miR-1268b-1.273) were substituted into the discriminant created for the learning sample group, and the discrimination score obtained is shown on the vertical axis, and the sample group is shown on the horizontal axis. In consideration of the ease of viewing the figure, 400 subjects each were randomly selected from subjects without lung cancer and lung cancer patients, and the discrimination scores are shown. The dotted line in the figure indicates the discrimination boundary for discriminating between the two groups with a discrimination score of 0. [Diagram 3] Top figure: The discrimination scores of the above validation sample group are illustrated separately for healthy subjects and each histological type of lung cancer (small cell carcinoma, adenocarcinoma, squamous cell carcinoma, large cell carcinoma, other lung cancer). The dotted line in the figure indicates the discrimination boundary for discriminating between the two groups with a discrimination score of 0. Bottom figure: The discrimination scores of the above validation sample group are illustrated separately for healthy subjects and each stage of lung cancer (Stage I, Stage II, Stage III / IV (Stage III and Stage IV)). The dotted line in the figure indicates the discrimination boundary for discriminating between the two groups with a discrimination score of 0. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0412] The present invention will now be described in more detail.

[0413] 1. Target nucleic acid for lung cancer Using the nucleic acid of the present invention, such as the nucleic acid probe or primer for detecting lung cancer as defined above, and as a lung cancer marker for detecting the presence and / or absence of lung cancer or lung cancer cells. The major target nucleic acids of all the genes are miR-6787-5p, miR-920, and miR-3622. a-5p, miR-1185-1-3p, miR-4327, miR-5739, miR -937-5p, miR-1181, miR-1185-2-3p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1246, miR-124 9-5p, miR-1292-3p, miR-1469, miR-1470, miR-1 97-5p, miR-208a-5p, miR-2110, miR-211-3p, mi R-2467-3p, miR-3122, miR-3141, miR-3156-5p, miR-3158-5p, miR-3160-5p, miR-3180-3p, miR- 3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620-5p, miR-370 -3p, miR-373-5p, miR-3917, miR-3937, miR-425 9, miR-4281, miR-4294, miR-4419b, miR-4428, m iR-4429, miR-4433a-3p, miR-4447, miR-4449, m iR-4459, miR-4480, miR-4485-5p, miR-4486, mi R-4488, miR-4489, miR-4505, miR-4513, miR-45 15, miR-4530, miR-4535, miR-4635, miR-4640-5 p, miR-4646-5p, miR-4656, miR-4663, and miR-4665 -5p, miR-4706, miR-4707-5p, miR-4708-3p, miR -4710, miR-4718, miR-4722-5p, miR-4727-3p, m iR-4730, miR-4734, miR-4740-5p, miR-4747-3p miR-4749-5p, miR-4755-3p, miR-4763-5p, miR -4787-3p, miR-5008-5p, miR-5010-5p, miR-504 -3p, miR-5090, miR-5100, miR-5196-5p, miR-55 1b-5p, miR-557, miR-5787, miR-6090, miR-6124 miR-6132, miR-6510-5p, miR-6511b-5p, miR-6 515-3p, miR-654-5p, miR-658, miR-668-5p, miR -6722-5p, miR-6724-5p, miR-6729-3p, miR-673 7-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p , miR-6766-5p, miR-6769a-5p, miR-6771-5p, mi R-6786-5p, miR-6789-5p, miR-6794-5p, miR-67 96-3p, miR-6797-5p, miR-6800-3p, miR-6802-5 p, miR-6803-5p, miR-6805-3p, miR-6805-5p, mi R-6807-5p, miR-6812-5p, miR-6819-5p, miR-68 22-5p, miR-6824-5p, miR-6826-5p, miR-6850-5 p, miR-6858-5p, miR-6861-5p, miR-6880-3p, mi R-7107-5p, miR-7109-5p, miR-7114-5p, miR-77 04, miR-7846-3p, miR-8052, miR-8060, miR-807 1, miR-8073, miR-874-5p, miR-204-3p, miR-315 4, miR-3960, miR-4433a-5p, miR-4455, miR-446 2, miR-4476, miR-4508, miR-4687-3p, miR-4687 -5p, miR-4732-5p, miR-4771, miR-642a-3p, miR -6732-5p, miR-6760-5p, miR-6799-5p, miR-682 0-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p , miR-7108-3p, miR-7111-5p, miR-8089, miR-88 At least one miRNA selected from the group consisting of miR-5-3p, miR-92b-3p Or a polynucleotide complementary to the miRNA is included. other lung cancer markers that can be combined with, namely, miR-1343-3p, miR-6746-5p, miR-422a, miR-187-5p, miR-4632 -5p, miR-6791-5p, miR-103a-3p, miR-107, miR- 1199-5p, miR-1225-3p, miR-1225-5p, miR-1228 -5p, miR-1229-5p, miR-1233-5p, miR-1237-5p, miR-1247-3p, miR-1249-3p, miR-1254, miR-126 0b, miR-1268a, miR-1268b, miR-1273g-3p, miR- 128-1-5p, miR-128-2-5p, miR-1290, miR-150-3 p, miR-17-3p, miR-1908-5p, miR-1909-3p, miR- 1914-3p, miR-1915-3p, miR-191-5p, miR-22-3p 、miR-23b-3p, miR-24-3p, miR-296-3p, miR-296 -5p, miR-3131, miR-3162-5p, miR-3188, miR-31 96, miR-3197, miR-320a, miR-342-5p, miR-3621 、miR-3648, miR-3656, miR-365a-5p, miR-3665, miR-3679-5p, miR-371a-5p, miR-3940-5p, miR- 423-5p, miR-4257, miR-4270, miR-4271, miR-42 86, miR-4298, miR-4417, miR-4442, miR-4446-3 p, miR-4448, miR-4454, miR-4467, miR-4472, mi R-4507, miR-4516, miR-451a, miR-4649-5p, miR -4651, miR-4665-3p, miR-4674, miR-4675, miR- 4689, miR-4695-5p, miR-4697-5p, miR-4725-3p miR-4739, miR-4745-5p, miR-4763-3p, miR-47 92, miR-486-3p, miR-5001-5p, miR-5195-3p, mi R-550a-5p, miR-5698, miR-6075, miR-6088, miR -6089, miR-6125, miR-6126, miR-614, miR-615- 5p, miR-619-5p, miR-638, miR-642b-3p, miR-65 0, miR-663a, miR-663b, miR-6717-5p, miR-6721 -5p, miR-6726-5p, miR-6727-5p, miR-6738-5p miR-6741-5p, miR-6749-5p, miR-6752-5p, miR- 675-5p, miR-6757-5p, miR-6763-5p, miR-6765- 5p, miR-6775-5p, miR-6780b-5p, miR-6782-5p miR-6784-5p, miR-6800-5p, miR-6806-5p, miR- 6840-3p, miR-6848-5p, miR-6851-5p, miR-6870 -5p, miR-6872-3p, miR-6875-5p, miR-6877-5p miR-6879-5p, miR-6880-5p, miR-6885-5p, miR- 6887-5p, miR-7108-5p, miR-711, miR-7113-3p miR-744-5p, miR-760, miR-7845-5p, miR-7847- 3p, miR-7977, miR-8059, miR-8063, miR-8072, m iR-874-3p, miR-92a-2-5p, miR-92b-5p, miR-94 0, miR-1228-3p, miR-1275, miR-1307-3p, miR-1 343-5p, miR-23a-3p, miR-29b-3p, miR-3135b, m iR-3185, miR-4532, miR-4690-5p, miR-4758-5p , miR-4783-3p, miR-6131, miR-625-3p, miR-651 1a-5p, miR-6765-3p, miR-6816-5p, miR-6825-5 p, miR-6845-5p, miR-7150, miR-7641, miR-7975 , miR-92a-3p, or the like. A polynucleotide complementary to a miRNA can also be preferably used as a target nucleic acid.

[0414] The above miRNA may, for example, comprise a base sequence represented by any one of SEQ ID NOs: 1 to 329. Human genes containing miR-6787-5p, miR-920, and miR-1111, respectively, R-3622a-5p, miR-1185-1-3p, miR-4327, miR-57 39, miR-937-5p, miR-1181, miR-1185-2-3p, miR -1193, miR-1207-5p, miR-1238-5p, miR-1246, m iR-1249-5p, miR-1292-3p, miR-1469, miR-1470 , miR-197-5p, miR-208a-5p, miR-2110, miR-211 -3p, miR-2467-3p, miR-3122, miR-3141, miR-31 56-5p, miR-3158-5p, miR-3160-5p, miR-3180-3 p, miR-3191-3p, miR-3194-3p, miR-320b, and miR-3 28-5p, miR-3610, miR-3619-3p, miR-3620-5p, m iR-370-3p, miR-373-5p, miR-3917, miR-3937, m iR-4259, miR-4281, miR-4294, miR-4419b, miR- 4428, miR-4429, miR-4433a-3p, miR-4447, miR- 4449, miR-4459, miR-4480, miR-4485-5p, miR-4 486, miR-4488, miR-4489, miR-4505, miR-4513 miR-4515, miR-4530, miR-4535, miR-4635, miR- 4640-5p, miR-4646-5p, miR-4656, miR-4663, mi R-4665-5p, miR-4706, miR-4707-5p, miR-4708- 3p, miR-4710, miR-4718, miR-4722-5p, miR-472 7-3p, miR-4730, miR-4734, miR-4740-5p, miR-4 747-3p, miR-4749-5p, miR-4755-3p, miR-4763- 5p, miR-4787-3p, miR-5008-5p, miR-5010-5p, m iR-504-3p, miR-5090, miR-5100, miR-5196-5p miR-551b-5p, miR-557, miR-5787, miR-6090, mi R-6124, miR-6132, miR-6510-5p, miR-6511b-5p miR-6515-3p, miR-654-5p, miR-658, miR-668- 5p, miR-6722-5p, miR-6724-5p, miR-6729-3p, m iR-6737-5p, miR-6756-5p, miR-6762-5p, miR-6 763-3p, miR-6766-5p, miR-6769a-5p, miR-6771 -5p, miR-6786-5p, miR-6789-5p, miR-6794-5p miR-6796-3p, miR-6797-5p, miR-6800-3p, miR- 6802-5p, miR-6803-5p, miR-6805-3p, miR-6805 -5p, miR-6807-5p, miR-6812-5p, miR-6819-5p miR-6822-5p, miR-6824-5p, miR-6826-5p, miR- 6850-5p, miR-6858-5p, miR-6861-5p, miR-6880 -3p, miR-7107-5p, miR-7109-5p, miR-7114-5p miR-7704, miR-7846-3p, miR-8052, miR-8060, and m iR-8071, miR-8073, miR-874-5p, miR-204-3p, m iR-3154, miR-3960, miR-4433a-5p, miR-4455, and m iR-4462, miR-4476, miR-4508, miR-4687-3p, mi R-4687-5p, miR-4732-5p, miR-4771, miR-642a- 3p, miR-6732-5p, miR-6760-5p, miR-6799-5p, m iR-6820-5p, miR-6821-5p, miR-6829-5p, miR-6 893-5p, miR-7108-3p, miR-7111-5p, miR-8089 miR-885-3p, miR-92b-3p, miR-1343-3p, miR-67 46-5p, miR-422a, miR-187-5p, miR-4632-5p, mi R-6791-5p, miR-103a-3p, miR-107, miR-1199-5 p, miR-1225-3p, miR-1225-5p, miR-1228-5p, mi R-1229-5p, miR-1233-5p, miR-1237-5p, miR-12 47-3p, miR-1249-3p, miR-1254, miR-1260b, miR -1268a, miR-1268b, miR-1273g-3p, miR-128-1- 5p, miR-128-2-5p, miR-1290, miR-150-3p, miR- 17-3p, miR-1908-5p, miR-1909-3p, miR-1914-3 p, miR-1915-3p, miR-191-5p, miR-22-3p, miR-2 3b-3p、miR-24-3p、miR-296-3p、miR-296-5p、mi R-3131, miR-3162-5p, miR-3188, miR-3196, miR -3197, miR-320a, miR-342-5p, miR-3621, miR-3 648, miR-3656, miR-365a-5p, miR-3665, miR-36 79-5p, miR-371a-5p, miR-3940-5p, miR-423-5p miR-4257, miR-4270, miR-4271, miR-4286, miR -4298, miR-4417, miR-4442, miR-4446-3p, miR- 4448, miR-4454, miR-4467, miR-4472, miR-4507 miR-4516, miR-451a, miR-4649-5p, miR-4651 miR-4665-3p, miR-4674, miR-4675, miR-4689, m iR-4695-5p, miR-4697-5p, miR-4725-3p, miR-4 739, miR-4745-5p, miR-4763-3p, miR-4792, miR -486-3p, miR-5001-5p, miR-5195-3p, miR-550a -5p, miR-5698, miR-6075, miR-6088, miR-6089 miR-6125, miR-6126, miR-614, miR-615-5p, miR -619-5p, miR-638, miR-642b-3p, miR-650, miR- 663a, miR-663b, miR-6717-5p, miR-6721-5p, mi R-6726-5p, miR-6727-5p, miR-6738-5p, miR-67 41-5p, miR-6749-5p, miR-6752-5p, miR-675-5p miR-6757-5p, miR-6763-5p, miR-6765-5p, miR -6775-5p, miR-6780b-5p, miR-6782-5p, miR-67 84-5p, miR-6800-5p, miR-6806-5p, miR-6840-3 p, miR-6848-5p, miR-6851-5p, miR-6870-5p, mi R-6872-3p, miR-6875-5p, miR-6877-5p, miR-68 79-5p, miR-6880-5p, miR-6885-5p, miR-6887-5 p, miR-7108-5p, miR-711, miR-7113-3p, miR-74 4-5p, miR-760, miR-7845-5p, miR-7847-3p, miR -7977, miR-8059, miR-8063, miR-8072, miR-874 -3p, miR-92a-2-5p, miR-92b-5p, miR-940, miR- 1228-3p, miR-1275, miR-1307-3p, miR-1343-5p , miR-23a-3p, miR-29b-3p, miR-3135b, miR-318 5, miR-4532, miR-4690-5p, miR-4758-5p, miR-4 783-3p, miR-6131, miR-625-3p, miR-6511a-5p, miR-6765-3p, miR-6816-5p, miR-6825-5p, miR- 6845-5p, miR-7150, miR-7641, miR-7975, miR-9 2a-3p), their homologs, their transcription products, and / or their variants or derivatives. Here, genes, homologues, transcripts, variants and derivatives are as defined above. .

[0415] A preferred target nucleic acid is a human gene comprising a base sequence represented by any one of SEQ ID NOs: 1 to 329. A gene, its transcription product, more preferably said transcription product, i.e., miRNA, its precursor R pri-miRNA or pre-miRNA or a polynucleotide complementary thereto This is the punch line.

[0416] The first target gene was the hsa-miR-6787-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0417] The second target gene is the hsa-miR-920 gene, its homologs, and their transcription factors. The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that altered expression could be a marker for lung cancer.

[0418] The third target gene was the hsa-miR-3622a-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0419] The fourth target gene is the hsa-miR-1185-1-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0420] The fifth target gene was the hsa-miR-4327 gene, its homologs, and their transcription factors. The gene or its transcription product, or its variant or derivative, is There are no known reports suggesting that changes in expression could be a marker for lung cancer.

[0421] The sixth target gene was the hsa-miR-5739 gene, its homologs, and their transcription factors. The gene or its transcription product, or its variant or derivative, is There are no known reports suggesting that changes in expression could be a marker for lung cancer.

[0422] The seventh target gene is the hsa-miR-937-5p gene, its homologs, or their variants or derivatives. There are no known reports indicating that changes in expression of the products could be markers for lung cancer.

[0423] The eighth target gene is the hsa-miR-1181 gene, its homologs, and their transcription factors. The gene or its transcription product, or its variant or derivative, is There are no known reports suggesting that changes in expression could be a marker for lung cancer.

[0424] The ninth target gene is the hsa-miR-1185-2-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0425] The tenth target gene is the hsa-miR-1193 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0426] The eleventh target gene is the hsa-miR-1207-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0427] The 12th target gene is the hsa-miR-1238-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0428] The 13th target gene is the hsa-miR-1246 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0429] The 14th target gene is the hsa-miR-1249-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0430] The fifteenth target gene is the hsa-miR-1292-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0431] The 16th target gene is the hsa-miR-1469 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0432] The 17th target gene is the hsa-miR-1470 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0433] The 18th target gene is the hsa-miR-197-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0434] The 19th target gene is the hsa-miR-208a-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0435] The 20th target gene is the hsa-miR-2110 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0436] The 21st target gene is the hsa-miR-211-3p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0437] The 22nd target gene is the hsa-miR-2467-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0438] The 23rd target gene is the hsa-miR-3122 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0439] The 24th target gene is the hsa-miR-3141 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0440] The 25th target gene is the hsa-miR-3156-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0441] The 26th target gene is the hsa-miR-3158-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0442] The 27th target gene is the hsa-miR-3160-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0443] The 28th target gene is the hsa-miR-3180-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0444] The 29th target gene is the hsa-miR-3191-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0445] The 30th target gene is the hsa-miR-3194-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0446] The 31st target gene is the hsa-miR-320b gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0447] The 32nd target gene is the hsa-miR-328-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0448] The 33rd target gene was the hsa-miR-3610 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0449] The 34th target gene is the hsa-miR-3619-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0450] The 35th target gene is the hsa-miR-3620-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0451] The 36th target gene is the hsa-miR-370-3p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0452] The 37th target gene is the hsa-miR-373-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0453] The 38th target gene is the hsa-miR-3917 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0454] The 39th target gene is the hsa-miR-3937 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0455] The 40th target gene is the hsa-miR-4259 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0456] The 41st target gene is the hsa-miR-4281 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0457] The 42nd target gene is the hsa-miR-4294 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0458] The 43rd target gene was the hsa-miR-4419b gene, its homologs, and their or their variants or derivatives. There are no known reports indicating that changes in expression of the products could be markers for lung cancer.

[0459] The 44th target gene is the hsa-miR-4428 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0460] The 45th target gene is the hsa-miR-4429 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0461] The 46th target gene is the hsa-miR-4433a-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0462] The 47th target gene is the hsa-miR-4447 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0463] The 48th target gene is the hsa-miR-4449 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0464] The 49th target gene is the hsa-miR-4459 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0465] The 50th target gene is the hsa-miR-4480 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0466] The 51st target gene is the hsa-miR-4485-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0467] The 52nd target gene is the hsa-miR-4486 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0468] The 53rd target gene was the hsa-miR-4488 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0469] The 54th target gene is the hsa-miR-4489 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0470] The 55th target gene is the hsa-miR-4505 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0471] The 56th target gene is the hsa-miR-4513 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0472] The 57th target gene is the hsa-miR-4515 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0473] The 58th target gene is the hsa-miR-4530 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0474] The 59th target gene is the hsa-miR-4535 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0475] The 60th target gene is the hsa-miR-4635 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0476] The 61st target gene is the hsa-miR-4640-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0477] The 62nd target gene is the hsa-miR-4646-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0478] The 63rd target gene was the hsa-miR-4656 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0479] The 64th target gene is the hsa-miR-4663 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0480] The 65th target gene is the hsa-miR-4665-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0481] The 66th target gene is the hsa-miR-4706 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0482] The 67th target gene is the hsa-miR-4707-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0483] The 68th target gene is the hsa-miR-4708-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0484] The 69th target gene is the hsa-miR-4710 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0485] The 70th target gene is the hsa-miR-4718 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0486] The 71st target gene is the hsa-miR-4722-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0487] The 72nd target gene is the hsa-miR-4727-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0488] The 73rd target gene was the hsa-miR-4730 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0489] The 74th target gene is the hsa-miR-4734 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0490] The 75th target gene is the hsa-miR-4740-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0491] The 76th target gene is the hsa-miR-4747-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0492] The 77th target gene is the hsa-miR-4749-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0493] The 78th target gene is the hsa-miR-4755-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0494] The 79th target gene is the hsa-miR-4763-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0495] The 80th target gene is the hsa-miR-4787-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0496] The 81st target gene is the hsa-miR-5008-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0497] The 82nd target gene is the hsa-miR-5010-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0498] The 83rd target gene is the hsa-miR-504-3p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0499] The 84th target gene is the hsa-miR-5090 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0500] The 85th target gene is the hsa-miR-5100 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0501] The 86th target gene is the hsa-miR-5196-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0502] The 87th target gene is the hsa-miR-551b-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0503] The 88th target gene was the hsa-miR-557 gene, its homologs, and their transcription factors. The gene or its transcription product, or its variant or derivative, is There are no known reports suggesting that changes in expression could be a marker for lung cancer.

[0504] The 89th target gene is the hsa-miR-5787 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0505] The 90th target gene is the hsa-miR-6090 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0506] The 91st target gene is the hsa-miR-6124 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0507] The 92nd target gene is the hsa-miR-6132 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports suggesting that changes in expression of these proteins could be markers for lung cancer.

[0508] The 93rd target gene is the hsa-miR-6510-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0509] The 94th target gene is the hsa-miR-6511b-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0510] The 95th target gene is the hsa-miR-6515-3p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0511] The 96th target gene is the hsa-miR-654-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0512] The 97th target gene was the hsa-miR-658 gene, its homologs, and their transcription factors. The gene or its transcription product, or its variant or derivative, is There are no known reports suggesting that changes in expression could be a marker for lung cancer.

[0513] The 98th target gene is the hsa-miR-668-5p gene, its homologs, and The gene or its transcription product, or a variant or derivative thereof, has been previously There are no known reports suggesting that altered expression of transcripts could be a marker for lung cancer.

[0514] The 99th target gene is the hsa-miR-6722-5p gene, its homologs, and The genes or their variants or derivatives are There are no known reports that altered transcript expression could be a marker for lung cancer.

[0515] The 100th target gene is the hsa-miR-6724-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0516] The 101st target gene is the hsa-miR-6729-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0517] The 102nd target gene is the hsa-miR-6737-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0518] The 103rd target gene is the hsa-miR-6756-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0519] The 104th target gene is the hsa-miR-6762-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0520] The 105th target gene is the hsa-miR-6763-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0521] The 106th target gene is the hsa-miR-6766-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0522] The 107th target gene is the hsa-miR-6769a-5p gene and its homologs , their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0523] The 108th target gene is the hsa-miR-6771-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0524] The 109th target gene is the hsa-miR-6786-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0525] The 110th target gene is the hsa-miR-6789-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0526] The 111th target gene is the hsa-miR-6794-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0527] The 112th target gene is the hsa-miR-6796-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0528] The 113th target gene is the hsa-miR-6797-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0529] The 114th target gene is the hsa-miR-6800-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0530] The 115th target gene is the hsa-miR-6802-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0531] The 116th target gene is the hsa-miR-6803-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0532] The 117th target gene is the hsa-miR-6805-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0533] The 118th target gene is the hsa-miR-6805-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0534] The 119th target gene is the hsa-miR-6807-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0535] The 120th target gene is the hsa-miR-6812-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0536] The 121st target gene is the hsa-miR-6819-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0537] The 122nd target gene is the hsa-miR-6822-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0538] The 123rd target gene is the hsa-miR-6824-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0539] The 124th target gene is the hsa-miR-6826-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0540] The 125th target gene is the hsa-miR-6850-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0541] The 126th target gene is the hsa-miR-6858-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0542] The 127th target gene is the hsa-miR-6861-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0543] The 128th target gene is the hsa-miR-6880-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0544] The 129th target gene is the hsa-miR-7107-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0545] The 130th target gene is the hsa-miR-7109-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0546] The 131st target gene is the hsa-miR-7114-5p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0547] The 132nd target gene is the hsa-miR-7704 gene, its homologs, and their or their variants or derivatives. There are no known reports suggesting that changes in expression of these products could be markers for lung cancer.

[0548] The 133rd target gene is the hsa-miR-7846-3p gene, its homologues, The genes or their transcription products, or their variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for lung cancer.

[0549] The 134th target gene is the hsa-miR-8052 gene, its homologs, and their or their variants or derivatives. There are no known reports suggesting that changes in expression of these products could be markers for lung cancer.

[0550] The 135th target gene is the hsa-miR-8060 gene, its homologs, and their or their variants or derivatives. There are no known reports suggesting that changes in expression of these products could be markers for lung cancer.

[0551] The 136th target gene is the hsa-miR-8071 gene, its homologs, and their or their variants or derivatives. There are no known reports suggesting that changes in expression of these products could be markers for lung cancer.

[0552] The 137th target gene is the hsa-miR-8...

Claims

1. miR-6787-5p, miR-920, miR-3622a-5p, miR-1185-1-3p, miR-4327, miR-5739, miR-937-5p, miR-1181, miR-1185-2-3p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1246, miR-1249-5p, miR-1292-3p, miR-1469, miR-1470, miR-197-5p, miR-208a-5p, miR-2110, miR-211-3p, miR-2467-3p, miR-3122, miR-3141, miR-3156-5p, miR-3158-5p, miR-3160-5p, miR-3180-3p, miR-3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620-5p, miR-370-3p, miR-373-5p, miR-3917, miR-3937, miR-4259, miR-4281, miR-4294, miR-4419b, miR-4428, miR-4429, miR-4433a-3p, miR-4447, miR-4449, miR-4459, miR-4480, miR-4485-5p, miR-4486, miR-4488, miR-4489, miR-4505, miR-4513, miR-4515, miR-4530, miR-4535, miR-4635, miR-4640-5p, miR-4646-5p, miR-4656, miR-4663, miR-4665-5p, miR-4706, miR-4707-5p, miR-4708-3p, miR-4710, miR-4718, miR-4722-5p, miR-4727-3p, miR-4730, miR-4734, miR-4740-5p, miR-4747-3p, miR-4749-5p, miR-4755-3p, miR-4763-5p, miR-4787-3p, miR-5008-5p, miR-5010-5p, miR-504-3p, miR-5090, miR-5100, miR-5196-5p, miR-551b-5p, miR-557, miR-5787, miR-6090, miR-6124, which are lung cancer markers ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ , miR-6132, miR-6510-5p, miR-6511b-5p, miR-6 515-3p, miR-654-5p, miR-658, miR-668-5p, miR -6722-5p, miR-6724-5p, miR-6729-3p, miR-673 7-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p , miR-6766-5p, miR-6769a-5p, miR-6771-5p, mi R-6786-5p, miR-6789-5p, miR-6794-5p, miR-67 96-3p, miR-6797-5p, miR-6800-3p, miR-6802-5 p, miR-6803-5p, miR-6805-3p, miR-6805-5p, mi R-6807-5p, miR-6812-5p, miR-6819-5p, miR-68 22-5p, miR-6824-5p, miR-6826-5p, miR-6850-5 p, miR-6858-5p, miR-6861-5p, miR-6880-3p, mi R-7107-5p, miR-7109-5p, miR-7114-5p, miR-77 04, miR-7846-3p, miR-8052, miR-8060, miR-807 1, miR-8073, miR-874-5p, miR-204-3p, miR-315 4, miR-3960, miR-4433a-5p, miR-4455, miR-446 2, miR-4476, miR-4508, miR-4687-3p, miR-4687 -5p, miR-4732-5p, miR-4771, miR-642a-3p, miR -6732-5p, miR-6760-5p, miR-6799-5p, miR-682 0-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p , miR-7108-3p, miR-7111-5p, miR-8089, miR-88 At least one polynucleotide selected from the group consisting of miR-5-3p, miR-92b-3p, and miR-92b-3p. or a polynucleotide having a base sequence complementary to the polynucleotide A kit for detecting lung cancer, comprising a nucleic acid capable of binding to

2. The nucleic acid is a polynucleotide represented by any one of (a) to (e) below: (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, a mutant thereof, a derivative or a fragment thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions A hybridizing polynucleotide, The kit of claim 1, wherein the polynucleotide is selected from the group consisting of:

3. The kit further comprises a marker for lung cancer, such as miR-1343-3p or miR-674. 6-5p, miR-422a, miR-187-5p, miR-4632-5p, miR -6791-5p, miR-103a-3p, miR-107, miR-1199-5p , miR-1225-3p, miR-1225-5p, miR-1228-5p, miR -1229-5p, miR-1233-5p, miR-1237-5p, miR-124 7-3p, miR-1249-3p, miR-1254, miR-1260b, miR- 1268a, miR-1268b, miR-1273g-3p, miR-128-1-5 p, miR-128-2-5p, miR-1290, miR-150-3p, miR-1 7-3p, miR-1908-5p, miR-1909-3p, miR-1914-3p , miR-1915-3p, miR-191-5p, miR-22-3p, miR-23 b-3p, miR-24-3p, miR-296-3p, miR-296-5p, miR -3131, miR-3162-5p, miR-3188, miR-3196, miR- 3197, miR-320a, miR-342-5p, miR-3621, miR-36 48, miR-3656, miR-365a-5p, miR-3665, miR-367 9-5p, miR-371a-5p, miR-3940-5p, miR-423-5p, miR-4257, miR-4270, miR-4271, miR-4286, miR- 4298, 17, 4442, 4446-3p, 4446-3p 448, miR-4454, miR-4467, miR-4472, miR-4507, miR-4516, miR-451a, miR-4649-5p, miR-4651, m iR-4665-3p, miR-4674, miR-4675, miR-4689, mi R-4695-5p,miR-4697-5p,miR-4725-3p,miR-47 39, miR-4745-5p, miR-4763-3p, miR-4792, miR- 486-3p,miR-5001-5p,miR-5195-3p,miR-550a� 5p, miR-5698, miR-6075, miR-6088, miR-6089, m iR-6125, miR-6126, miR-614, miR-615-5p, miR- 619-5p,miR-638,miR-642b-3p,miR-650,miR-6 63a, miR, -6717-5p, miR, -6721-5p, miR -6726-5p, miR-6727-5p, miR-6738-5p, miR-674 1-5p, miR-6749-5p, miR-6752-5p, miR-675-5p, miR-6757-5p,miR-6763-5p,miR-6765-5p,miR- 6775-5p,miR-6780b-5p,miR-6782-5p,miR-678 4-5p, miR-680-5p, miR-6806-5p, miR-6840-3p 、miR-6848-5p, miR-6851-5p, miR-6870-5p, miR -6872-3p,miR-6875-5p,miR-687-5p,miR-687 9-5p, miR-6880-5p, miR-6885-5p, miR-6887-5p 、miR-7108-5p, miR-711, miR-7113-3p, miR-744 -5p, miR-760, miR-7845-5p, miR-7847-3p, miR- 7977, miR-8059, miR-8063, miR-8072, miR-874- 3p, miR-92a-2-5p, miR-92b-5p, miR-940, miR-1 228-3p,miR-1275,miR-1307-3p,miR-1343-5p, miR-23a-3p, miR-29b-3p, miR-3135b, miR-3185 , miR-4532, miR-4690-5p, miR-4758-5p, miR-47 83-3p, miR-6131, miR-625-3p, miR-6511a-5p, m iR-6765-3p, miR-6816-5p, miR-6825-5p, miR-6 845-5p, miR-7150, miR-7641, miR-7975, miR-92 a-3p or at least one polynucleotide selected from the group consisting of A nucleic acid capable of specifically binding to a polynucleotide having a base sequence complementary to the nucleic acid is further provided. The kit according to claim 1 or 2, comprising:

4. The nucleic acid is a polynucleotide represented by any one of (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases; (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, or a mutant thereof; a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (j) A method for producing a nucleic acid sequence comprising the step of: A hybridizing polynucleotide, The kit of claim 3, wherein the polynucleotide is selected from the group consisting of:

5. Lung cancer markers: miR-6787-5p, miR-920, and miR-3622 a-5p, miR-1185-1-3p, miR-4327, miR-5739, miR -937-5p, miR-1181, miR-1185-2-3p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1246, miR-124 9-5p, miR-1292-3p, miR-1469, miR-1470, miR-1 97-5p, miR-208a-5p, miR-2110, miR-211-3p, mi R-2467-3p, miR-3122, miR-3141, miR-3156-5p, miR-3158-5p,miR-3160-5p,miR-3180-3p,miR- 3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620-5p, miR-370 -3p, miR-373-5p, miR-3917, miR-3937, miR-425 9, miR-4294, miR-4419b, miR-4428, m iR-4429, miR-4433a-3p, miR-447, miR-449, m iR-4459, miR-4480, miR-4485-5p, miR-4486, mi R-488, 9-)R-489, 05, 13, 3R-45 15, miR-4530, miR-4640-5, miR-4640-5 p, miR-4646-5p, miR-4656, miR-463, miR-466 -5p, miR, -4707-5p, miR, -4708-3p, miR -4710,-4718,-4722-5p,-4727-3p,m iR-4734, miR-4740-5p, miR-4747-3p 、miR-4749-5p, miR-4755-3p, miR-4763-5p, miR -4787-3p,miR-5008-5p,miR-5010-5p,miR-504 -3p,miR-5090,miR-5100,miR-5196-5p,miR-55 1b-5p, miR-557, miR-5787, miR-6090, miR-6124 、miR-6132, miR-6510-5p, miR-6511b-5p, miR-6 515-3p,miR-654-5p,miR-658,miR-668-5p,miR -6722-5p,miR-6724-5p,miR-6729-3p,miR-673 7-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p 、miR-6769a-5p, miR-6769a-5p, miR-6771-5p, mi R-6786-5p,miR-6789-5p,miR-6794-5p,miR-67 96-3p,miR-6797-5p,miR-6800-3p,miR-6802-5 p, miR-6803-5p, miR-6805-3p, miR-6805-5p, mi R-6807-5p, miR-6812-5p, miR-6819-5p, miR-68 22-5p, miR-6824-5p, miR-6826-5p, miR-6850-5 p, miR-6858-5p, miR-6861-5p, miR-6880-3p, mi R-7107-5p, miR-7109-5p, miR-7114-5p, miR-77 04, miR-7846-3p, miR-8052, miR-8060, miR-807 1, miR-8073, miR-874-5p, miR-204-3p, miR-315 4, miR-3960, miR-4433a-5p, miR-4455, miR-446 2, miR-4476, miR-4508, miR-4687-3p, miR-4687 -5p, miR-4732-5p, miR-4771, miR-642a-3p, miR -6732-5p, miR-6760-5p, miR-6799-5p, miR-682 0-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p , miR-7108-3p, miR-7111-5p, miR-8089, miR-88 At least one polynucleotide selected from the group consisting of miR-5-3p, miR-92b-3p, and miR-92b-3p. or a polynucleotide having a base sequence complementary to the polynucleotide A device for detecting lung cancer comprising a nucleic acid capable of binding to.

6. The nucleic acid is a polynucleotide represented by any one of (a) to (e) below: (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, a mutant thereof, a derivative or a fragment thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions A hybridizing polynucleotide, The device of claim 5, wherein the polynucleotide is selected from the group consisting of:

7. The device further comprises a marker for lung cancer, miR-1343-3p, miR-67 46-5p, miR-422a, miR-187-5p, miR-4632-5p, mi R-6791-5p, miR-103a-3p, miR-107, miR-1199-5 p, miR-1225-3p, miR-1225-5p, miR-1228-5p, mi R-1229-5p, miR-1233-5p, miR-1237-5p, miR-12 47-3p, miR-1249-3p, miR-1254, miR-1260b, miR -1268a, miR-1268b, miR-1273g-3p, miR-128-1- 5p, miR-128-2-5p, miR-1290, miR-150-3p, miR- 17-3p, miR-1908-5p, miR-1909-3p, miR-1914-3 p, miR-1915-3p, miR-191-5p, miR-22-3p, miR-2 3b-3p, miR-24-3p, miR-296-3p, miR-296-5p, mi R-3131, miR-3162-5p, miR-3188, miR-3196, miR -3197, miR-320a, miR-342-5p, miR-3621, miR-3 648, miR-3656, miR-365a-5p, miR-3665, miR-36 79-5p, miR-371a-5p, miR-3940-5p, miR-423-5p , miR-4257, miR-4270, miR-4271, miR-4286, miR -4298, miR-4417, miR-4442, miR-4446-3p, miR- 4448, miR-4454, miR-4467, miR-4472, miR-4507 , miR-4516, miR-451a, miR-4649-5p, miR-4651, miR-4665-3p, miR-4674, miR-4675, miR-4689, m iR-4695-5p, miR-4697-5p, miR-4725-3p, miR-4 739, miR-4745-5p, miR-4763-3p, miR-4792, miR -486-3p, miR-5001-5p, miR-5195-3p, miR-550a -5p, miR-5698, miR-6075, miR-6088, miR-6089, miR-6125, miR-6126, miR-614, miR-615-5p, miR -619-5p, miR-638, miR-642b-3p, miR-650, miR- 663a, miR-663b, miR-6717-5p, miR-6721-5p, mi R-6726-5p, miR-6727-5p, miR-6738-5p, miR-67 41-5p, miR-6749-5p, miR-6752-5p, miR-675-5p , miR-6757-5p, miR-6763-5p, miR-6765-5p, miR -6775-5p, miR-6780b-5p, miR-6782-5p, miR-67 84-5p, miR-6800-5p, miR-6806-5p, miR-6840-3 p, miR-6848-5p, miR-6851-5p, miR-6870-5p, mi R-6872-3p, miR-6875-5p, miR-6877-5p, miR-68 79-5p, miR-6880-5p, miR-6885-5p, miR-6887-5 p, miR-7108-5p, miR-711, miR-7113-3p, miR-74 4-5p, miR-760, miR-7845-5p, miR-7847-3p, miR -7977, miR-8059, miR-8063, miR-8072, miR-874 -3p, miR-92a-2-5p, miR-92b-5p, miR-940, miR- 1228-3p, miR-1275, miR-1307-3p, miR-1343-5p , miR-23a-3p, miR-29b-3p, miR-3135b, miR-318 5, miR-4532, miR-4690-5p, miR-4758-5p, miR-4 783-3p, miR-6131, miR-625-3p, miR-6511a-5p, miR-6765-3p, miR-6816-5p, miR-6825-5p, miR- 6845-5p, miR-7150, miR-7641, miR-7975, miR-9 At least one polynucleotide selected from the group consisting of 2a-3p or the polynucleotide A nucleic acid capable of specifically binding to a polynucleotide having a base sequence complementary to the nucleotide is also provided. The device according to claim 5 or 6, further comprising:

8. The nucleic acid is a polynucleotide represented by any one of (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases; (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, or a mutant thereof; a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (j) A method for producing a nucleic acid sequence comprising the step of: A hybridizing polynucleotide, The device of claim 7, wherein the polynucleotide is selected from the group consisting of:

9. The device is a device for measurement by a hybridization technique. The device according to any one of claims 5 to 8.

10. The device according to claim 9, wherein the hybridization technique is a nucleic acid array technique. vinegar.

11. In the subject's sample, lung cancer markers miR-6787-5p and miR-9 20, miR-3622a-5p, miR-1185-1-3p, miR-4327, m iR-5739, miR-937-5p, miR-1181, miR-1185-2-3 p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1 246, miR-1249-5p, miR-1292-3p, miR-1469, miR -1470, miR-197-5p, miR-208a-5p, miR-2110, mi R-211-3p, miR-2467-3p, miR-3122, miR-3141, m iR-3156-5p, miR-3158-5p, miR-3160-5p, miR-3 180-3p, miR-3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620 -5p, miR-370-3p, miR-373-5p, miR-3917, miR-3 937, miR-4259, miR-4294, miR-4419b 、miR-4428, miR-4429, miR-4433a-3p, miR-447 miR-449, miR-4459, miR-4480, miR-4485-5p, miR-4486, miR-4488, miR-4489, miR-4505, miR- 4513, 4515, 4515, 4530, 4535, 4635 、miR-4640-5p、miR-4646-5p、miR-4656、miR-46 63, 4665-5p, 706, 4707-5p, 707-5p, 70R- 4708-3p,miR-4710,miR-4718,miR-4722-5p,mi R-4727-3p, miR-4730, miR-4740-5p, miR-4747-3p,miR-4749-5p,miR-4755-3p,miR- 4763-5p,miR-4787-3p,miR-5008-5p,miR-5010 -5p, miR-504-3p, miR-5090, miR-5100, miR-519 6-5p, miR-551b-5p, miR-557, miR-5787, miR-60 90, 124, 132, 10-5p, 10-5p, 132 1b-5p, miR-6515-3p, miR-654-5p, miR-658, miR -668-5p,miR-6722-5p,miR-6724-5p,miR-6729 -3p, miR-6737-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p, miR-676-5p, miR-6769a-5p, miR -6771-5p,miR-6786-5p,miR-6789-5p,miR-679 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 、miR-6802-5p, miR-6803-5p, miR-6805-3p, miR -6805-5p,miR-6807-5p,miR-6812-5p,miR-681 9-5p, miR-682-5p, miR-6824-5p, miR-6826-5p 、miR-6850-5p、miR-6858-5p、miR -6880-3p, miR-7107-5p, miR-7109-5p, miR-711 4-5p, miR-7704, miR-7846-3p, miR-8052, miR-8 060, miR-8071, miR-8073, miR-874-5p, miR-204 -3p, miR-3154, miR-3960, miR-4433a-5p, miR-4 455, miR-4462, miR-4476, miR-4508, miR-4687- 3p, miR-4687-5p, miR-4732-5p, miR-4771, miR- 642a-3p, miR-6732-5p, miR-6760-5p, miR-6799 -5p, miR-6820-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, miR- 8089, miR-885-3p, miR-92b-3p and determining whether the subject has a specific expression level of at least one polynucleotide using the determined expression level. In vitro assessment of lung cancer or its absence A method for detecting lung cancer, comprising:

12. In the subject's sample, lung cancer markers miR-6787-5p and miR-9 20, miR-3622a-5p, miR-1185-1-3p, miR-4327, m iR-5739, miR-937-5p, miR-1181, miR-1185-2-3 p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1 246, miR-1249-5p, miR-1292-3p, miR-1469, miR -1470, miR-197-5p, miR-208a-5p, miR-2110, mi R-211-3p, miR-2467-3p, miR-3122, miR-3141, m iR-3156-5p, miR-3158-5p, miR-3160-5p, miR-3 180-3p, miR-3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620 -5p, miR-370-3p, miR-373-5p, miR-3917, miR-3 937, miR-4259, miR-4281, miR-4294, miR-4419b 、miR-4428, miR-4429, miR-4433a-3p, miR-447 miR-449, miR-4459, miR-4480, miR-4485-5p, miR-4486, miR-4488, miR-4489, miR-4505, miR- 4513, 4515, 4515, 4530, 4535, 4635 、miR-4640-5p、miR-4646-5p、miR-4656、miR-46 63, 4665-5p, 706, 4707-5p, 707-5p, 70R- 4708-3p,miR-4710,miR-4718,miR-4722-5p,mi R-4727-3p, miR-4730, miR-4740-5p, miR-4747-3p,miR-4749-5p,miR-4755-3p,miR- 4763-5p,miR-4787-3p,miR-5008-5p,miR-5010 -5p, miR-504-3p, miR-5090, miR-5100, miR-519 6-5p, miR-551b-5p, miR-557, miR-5787, miR-60 90, 124, 132, 10-5p, 10-5p, 132 1b-5p, miR-6515-3p, miR-654-5p, miR-658, miR -668-5p,miR-6722-5p,miR-6724-5p,miR-6729 -3p, miR-6737-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p, miR-676-5p, miR-6769a-5p, miR -6771-5p,miR-6786-5p,miR-6789-5p,miR-679 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 、miR-6802-5p, miR-6803-5p, miR-6805-3p, miR -6805-5p,miR-6807-5p,miR-6812-5p,miR-681 9-5p, miR-682-5p, miR-6824-5p, miR-6826-5p 、miR-6850-5p、miR-6858-5p、miR -6880-3p,miR-7107-5p,miR-7109-5p,miR-711 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 69, 70, 71, 72 060, miR-8071, miR-8073, miR-874-5p, miR-204 -3p, miR-3154, miR-3960, miR-4433a-5p, miR-4 455, miR-4462, miR-4476, miR-4508, miR-4687- 3p, miR-4687-5p, miR-4732-5p, miR-4771, miR- 642a-3p, miR-6732-5p, miR-6760-5p, miR-6799 -5p, miR-6820-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, miR- 8089, miR-885-3p, miR-92b-3p The expression level of at least one polynucleotide is measured, and the measured expression level and a similarly measured The expression level of the subject is compared with that of a control healthy person to determine whether the subject is suffering from lung cancer or not. A method for detecting lung cancer comprising in vitro assessment of the absence of lung cancer.

13. In the subject's sample, lung cancer markers miR-6787-5p and miR-9 20, miR-3622a-5p, miR-1185-1-3p, miR-4327, m iR-5739, miR-937-5p, miR-1181, miR-1185-2-3 p, miR-1193, miR-1207-5p, miR-1238-5p, miR-1 246, miR-1249-5p, miR-1292-3p, miR-1469, miR -1470, miR-197-5p, miR-208a-5p, miR-2110, mi R-211-3p, miR-2467-3p, miR-3122, miR-3141, m iR-3156-5p, miR-3158-5p, miR-3160-5p, miR-3 180-3p, miR-3191-3p, miR-3194-3p, miR-320b, miR-328-5p, miR-3610, miR-3619-3p, miR-3620 -5p, miR-370-3p, miR-373-5p, miR-3917, miR-3 937, miR-4259, miR-4281, miR-4294, miR-4419b , miR-4428, miR-4429, miR-4433a-3p, miR-4447 miR-449, miR-4459, miR-4480, miR-4485-5p, miR-4486, miR-4488, miR-4489, miR-4505, miR- 4513, 4515, 4515, 4530, 4535, 4635 、miR-4640-5p、miR-4646-5p、miR-4656、miR-46 63, 4665-5p, 706, 4707-5p, 707-5p, 70R- 4708-3p,miR-4710,miR-4718,miR-4722-5p,mi R-4727-3p, miR-4730, miR-4740-5p, miR-4747-3p,miR-4749-5p,miR-4755-3p,miR- 4763-5p,miR-4787-3p,miR-5008-5p,miR-5010 -5p, miR-504-3p, miR-5090, miR-5100, miR-519 6-5p, miR-551b-5p, miR-557, miR-5787, miR-60 90, 124, 132, 10-5p, 10-5p, 132 1b-5p, miR-6515-3p, miR-654-5p, miR-658, miR -668-5p,miR-6722-5p,miR-6724-5p,miR-6729 -3p, miR-6737-5p, miR-6756-5p, miR-6762-5p, miR-6763-3p, miR-676-5p, miR-6769a-5p, miR -6771-5p,miR-6786-5p,miR-6789-5p,miR-679 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 、miR-6802-5p, miR-6803-5p, miR-6805-3p, miR -6805-5p,miR-6807-5p,miR-6812-5p,miR-681 9-5p, miR-682-5p, miR-6824-5p, miR-6826-5p 、miR-6850-5p、miR-6858-5p、miR -6880-3p,miR-7107-5p,miR-7109-5p,miR-711 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 69, 70, 71, 72 060, miR-8071, miR-8073, miR-874-5p, miR-204 -3p, miR-3154, miR-3960, miR-4433a-5p, miR-4 455, miR-4462, miR-4476, miR-4508, miR-4687- 3p, miR-4687-5p, miR-4732-5p, miR-4771, miR- 642a-3p, miR-6732-5p, miR-6760-5p, miR-6799 -5p, miR-6820-5p, miR-6821-5p, miR-6829-5p, miR-6893-5p, miR-7108-3p, miR-7111-5p, miR- 8089, miR-885-3p, miR-92b-3p The expression level of at least one polynucleotide is measured in a subject known to have lung cancer. Gene expression levels in samples from subjects with and without lung cancer The test was created using the sample as a teacher sample, and was able to discriminate between the presence or absence of lung cancer. The discriminant is capable of detecting at least one polynucleotide in a sample derived from the subject. The expression level of tid was then substituted into the marker, and the presence or absence of lung cancer was evaluated in vitro. A method for detecting lung cancer, comprising: evaluating a lung cancer cell line comprising:

14. A polynucleotide having a base sequence complementary to the polynucleotide or the polynucleotide The expression level of the polynucleotide is measured using a nucleic acid capable of specifically binding to the nucleotide. The nucleic acid is a polynucleotide represented by any one of (a) to (e) below: (a) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or a polynucleotide having 15 or more bases A fragment thereof containing the above consecutive bases, (b) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 163; (c) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide having a base sequence complementary to the base sequence in which u is t, a mutant thereof, a derivative or a fragment thereof containing 15 or more consecutive bases; (d) a base sequence represented by any one of SEQ ID NOs: 1 to 163 or the base sequence A polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions A hybridizing polynucleotide, The polynucleotide according to any one of claims 11 to 13, which is selected from the group consisting of The method described.

15. Other lung cancer markers, miR-1343-3p, miR-6746-5p, mi R-422a, miR-187-5p, miR-4632-5p, miR-6791-5 p, miR-103a-3p, miR-107, miR-1199-5p, miR-12 25-3p, miR-1225-5p, miR-1228-5p, miR-1229-5 p, miR-1233-5p, miR-1237-5p, miR-1247-3p, mi R-1249-3p, miR-1254, miR-1260b, miR-1268a, m iR-1268b, miR-1273g-3p, miR-128-1-5p, miR-1 28-2-5p, miR-1290, miR-150-3p, miR-17-3p, mi R-1908-5p, miR-1909-3p, miR-1914-3p, miR-19 15-3p, miR-191-5p, miR-22-3p, miR-23b-3p, mi R-24-3p, miR-296-3p, miR-296-5p, miR-3131, m iR-3162-5p, miR-3188, miR-3196, miR-3197, mi R-320a, miR-342-5p, miR-3621, miR-3648, miR- 3656, miR-365a-5p, miR-3665, miR-3679-5p, mi R-371a-5p, miR-3940-5p, miR-423-5p, miR-425 7, miR-4270, miR-4271, miR-4286, miR-4298, mi R-4417, miR-4442, miR-4446-3p, miR-4448, miR -4454, miR-4467, miR-4472, miR-4507, miR-451 6, miR-451a, miR-4649-5p, miR-4651, miR-4665 -3p, miR-4674, miR-4675, miR-4689, miR-4695- 5p, miR-4697-5p, miR-4725-3p, miR-4739, miR- 4745-5p, miR-4763-3p, miR-4792, miR-486-3p, miR-5001-5p, miR-5195-3p, miR-550a-5p, miR- 5698, miR-6075, miR-6088, miR-6089, miR-6125 , miR-6126, miR-614, miR-615-5p, miR-619-5p, miR-638, miR-642b-3p, miR-650, miR-663a, miR -663b, miR-6717-5p, miR-6721-5p, miR-6726-5 p, miR-6727-5p, miR-6738-5p, miR-6741-5p, mi R-6749-5p, miR-6752-5p, miR-675-5p, miR-675 7-5p, miR-6763-5p, miR-6765-5p, miR-6775-5p , miR-6780b-5p, miR-6782-5p, miR-6784-5p, mi R-6800-5p, miR-6806-5p, miR-6840-3p, miR-68 48-5p, miR-6851-5p, miR-6870-5p, miR-6872-3 p, miR-6875-5p, miR-6877-5p, miR-6879-5p, mi R-6880-5p, miR-6885-5p, miR-6887-5p, miR-71 08-5p, miR-711, miR-7113-3p, miR-744-5p, miR -760, miR-7845-5p, miR-7847-3p, miR-7977, mi R-8059, miR-8063, miR-8072, miR-874-3p, miR- 92a-2-5p, miR-92b-5p, miR-940, miR-1228-3p, miR-1275, miR-1307-3p, miR-1343-5p, miR-23a -3p, miR-29b-3p, miR-3135b, miR-3185, miR-45 32, miR-4690-5p, miR-4758-5p, miR-4783-3p, m iR-6131, miR-625-3p, miR-6511a-5p, miR-6765 -3p, miR-6816-5p, miR-6825-5p, miR-6845-5p, miR-7150, miR-7641, miR-7975, miR-92a-3p and measuring the expression level of at least one polynucleotide selected from the group consisting of The method according to any one of claims 11 to 14, comprising:

16. A polynucleotide having a base sequence complementary to the polynucleotide or the polynucleotide The expression level of the polynucleotide is measured using a nucleic acid capable of specifically binding to the nucleotide. The nucleic acid is a polynucleotide represented by any one of (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence in which u is t, a variant thereof, a derivative thereof, or A fragment thereof containing 5 or more consecutive bases; (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 164 to 329; (h) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide having a base sequence complementary to the base sequence in which u is t, or a mutant thereof; a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 164 to 329 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; and (j) A method for producing a nucleic acid sequence comprising the step of: A hybridizing polynucleotide, The method of claim 15, wherein the polynucleotide is selected from the group consisting of:

17. A polynucleotide having a base sequence complementary to the polynucleotide or the polynucleotide The kit according to any one of claims 1 to 4, comprising a nucleic acid capable of specifically binding to a nucleic acid. Alternatively, a method for detecting a pre-existing condition in a specimen of a subject using the device according to any one of claims 5 to 10. The method according to any one of claims 11 to 16, wherein the expression level of the polynucleotide is measured. 。

18. The method of any one of claims 11 to 17, wherein the subject is a human.

19. The method according to any one of claims 11 to 18, wherein the sample is blood, serum or plasma. Law.

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