Fixed quantity injection aerosol product

Abstract

To provide a fixed quantity injection aerosol product allowing injected particles to easily diffuse.SOLUTION: A fixed quantity injection aerosol product comprises: an aerosol composition comprising a stock solution and a liquefied gas; and an aerosol container filled with an aerosol composition. The aerosol container comprises: a container body filled with the aerosol composition; and a fixed quantity valve which is attached to the container body and comprises a fixed quantity chamber; and an injection member including a nozzle for injecting the aerosol composition. A volume ratio of stock solution and a liquefied gas (stock solution / liquefied gas) is 60 / 40 to 5 / 95. A pressure at 25°C, of the aerosol composition stored in the fixed quantity chamber is 0.3 to 0.6 Mpa. An injection capacity of the fixed quantity valve injection is 0.1 to 2.0 mL. An injection force of the aerosol composition injected from the nozzle at an injection distance of 20 cm is 10 gf or more.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a metered dose aerosol product, more particularly to a metered dose aerosol product in which the sprayed particles tend to disperse. [Background technology]

[0002] Conventionally, there have been known metered-dose aerosol products for spraying a predetermined amount of content. Patent Document 1 discloses a metered-dose aerosol for mosquito control, which has a spray volume of 0.1 to 0.4 mL and a spray force of 0.3 to 10.0 g·f (25°C) at a spray distance of 20 cm. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-50829 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, the fixed-dose aerosol for mosquito control described in Patent Document 1 leaves room for improvement in terms of the diffusibility of the sprayed particles (spray material).

[0005] The present invention has been made in view of the above-mentioned conventional techniques, and has an object to provide a metered-amount aerosol product in which the sprayed particles are easily dispersed. [Means for solving the problem]

[0006] The metered dose aerosol product of the present invention that solves the above problems mainly comprises the following components.

[0007] (1) A metered-dose aerosol product comprising an aerosol composition comprising a concentrate and liquefied gas, and an aerosol container in which the aerosol composition is filled, the aerosol container comprising a container body in which the aerosol composition is filled, a metered-dose valve attached to the container body and equipped with a metered-dose chamber, and a spray member having a spray hole for spraying the aerosol composition, the volume ratio of the concentrate to the liquefied gas (concentrate / liquefied gas) being 60 / 40 to 5 / 95, the pressure of the aerosol composition stored in the metered chamber at 25°C being 0.3 to 0.6 MPa, the spray volume of the metered-dose valve being 0.1 to 2.0 mL, and the spray force of the aerosol composition sprayed from the spray hole being 10 gf or more at a spray distance of 20 cm.

[0008] With this configuration, the particles of the metered dose aerosol product tend to spread when sprayed. Effect of the Invention

[0009] According to the present invention, it is possible to provide a metered dose aerosol product in which the sprayed particles are easily dispersed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] <Fixed-volume aerosol product> A metered-dose aerosol product according to one embodiment of the present invention (hereinafter, simply referred to as an aerosol product) comprises an aerosol composition comprising a concentrate and liquefied gas, and an aerosol container filled with the aerosol composition. The aerosol container comprises a container body filled with the aerosol composition, a metered valve attached to the container body and equipped with a metered chamber, and a spray member having a spray hole for spraying the aerosol composition. The volume ratio of the concentrate to the liquefied gas (concentrate / liquefied gas) is 60 / 40 to 5 / 95. The pressure of the aerosol composition stored in the metered chamber at 25°C is 0.3 to 0.6 MPa. The spray capacity of the metered valve is 0.1 to 2.0 mL. The spray force of the aerosol composition sprayed from the spray hole exceeds 10 gf at a spray distance of 20 cm. Each of these will be described below.

[0011] (Aerosol Composition) Stock solution The concentrate is not particularly limited. For example, the concentrate contains an active ingredient and a solvent.

[0012] Examples of active ingredients include fragrances such as floral, green, citrus green, green floral, citrus, rose, rosewood, herbal wood, lemon, and peppermint; pH adjusters such as citric acid and lactic acid; chelating agents such as disodium edetate; pest repellents such as N,N-diethyl-m-toluamide (DEET), di-n-butyl succinate, hydroxyanisole, rotenone, ethyl-butyl acetylaminopropionate, icaridin (picaridin), p-menthane-3,8-diol, ethyl 3-[acetyl(butyl)amino]propionate, 1-methylpropyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, and herbal extracts; phthalthrin, fenothrin, allethrin, permethrin, cismethrin, and proparulsrin. These include insecticidal ingredients such as resmethrin, d-fenothrin, tefluthrin, benfluthrin, and transfluthrin, efficacy enhancers such as sinepirin, piperonyl butoxite, and octachlorodipropyl ether, deodorizing ingredients such as methyl benzoate, benzyl acetate, lauric acid methacrylate, methyl benzoate, phenylmethyl acetate, geranyl clotorate, acetophenone myristate, benzyl acetate, benzyl propionate, and green tea extract, and bactericidal ingredients such as isopropyl methylphenol, thymol, carvacrol, phenoxyethanol, paraoxybenzoic acid esters, sodium benzoate, potassium sorbate, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride, photosensitizers, parachlormetacresol, and hinokitiol.

[0013] The content of the active ingredient in the concentrate is preferably 0.1% by mass or more, more preferably 0.3% by mass or more. The content of the active ingredient in the concentrate is preferably 20% by mass or less, more preferably 15% by mass or less. When the content of the active ingredient is within the above range, the aerosol product is easily diffused and the effect of the active ingredient is easily obtained when a fixed amount of the aerosol product is sprayed as described below.

[0014] The solvent is not particularly limited. For example, the solvent may be water such as purified water, ion-exchanged water, physiological saline, deep sea water, etc.; monohydric alcohols having 2 to 3 carbon atoms such as propanol, isopropanol, isobutyl alcohol, t-butyl alcohol, etc.; ester oils such as isopropyl myristate, isopropyl palmitate, cetyl isooctanoate, octyl hydroxystearate, methyl pentanediol dineopentanoate, diethyl pentanediol dineopentanoate, etc.; hydrocarbon oils such as liquid paraffin, isoparaffin, normal paraffin, etc.; silicone oils such as dimethicone, methyl polysiloxane, cyclopentasiloxane, cyclohexasiloxane, methyl phenyl polysiloxane, etc.; higher fatty acids such as oleic acid, isostearic acid, linoleic acid, linoleic acid, etc.; higher alcohols such as oleyl alcohol, isostearyl alcohol, etc.; and the like.

[0015] The content of the solvent in the concentrate is preferably 60% by mass or more, more preferably 70% by mass or more. The content of the solvent in the concentrate is preferably 99.5% by mass or less, more preferably 99% by mass or less. By having the content of the solvent within the above range, the pressure of the aerosol composition in the aerosol product is stable, and a stable spray force is easily obtained.

[0016] The concentrate may contain, in addition to the above-mentioned active ingredient and solvent, a surfactant, a polyhydric alcohol, a solid oil agent, a powder, and the like, as appropriate.

[0017] Surfactants include non-ionic surfactants such as alkyl glucoside, polyoxyethylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether fatty acid ester, polyoxyethylene sorbit fatty acid ester, fatty acid soap, alkyl sulfate, polyoxyethylene alkyl ether sulfate, N-acyl amino acid salt, N-acyl methyl taurine salt, polyoxyethylene These include anionic surfactants such as ethylene alkyl ether acetates and alkyl phosphates; cationic surfactants such as alkyl ammonium salts and alkyl benzyl ammonium salts; amphoteric surfactants such as lauryl betaine, stearyl betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyl dimethylaminoacetate betaine, and cocamidopropyl betaine; silicone-based surfactants such as polyoxyethylene-methylpolysiloxane copolymers, polyoxypropylene-methylpolysiloxane copolymers, and poly(oxyethylene-oxypropylene)-methylpolysiloxane copolymers; and natural surfactants such as sodium surfactin and cyclodextrin.

[0018] When a surfactant is contained, the content of the surfactant is not particularly limited. For example, the content of the surfactant in the concentrate is preferably 0.1% by mass or more, more preferably 0.3% by mass or more. The content of the surfactant in the concentrate is preferably 10% by mass or less, more preferably 8% by mass or less. By having the content of the surfactant within the above range, the aerosol product is likely to obtain the effect of the surfactant.

[0019] Examples of polyhydric alcohols include ethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, xylitol, sorbitol, mannitol, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, diglycerin, polyethylene glycol, and triglycerin.

[0020] When polyhydric alcohol is contained, the content of polyhydric alcohol is not particularly limited. For example, the content of polyhydric alcohol in the concentrate is preferably 0.1% by mass or more, more preferably 0.3% by mass or more. The content of polyhydric alcohol in the concentrate is preferably 20% by mass or less, more preferably 15% by mass or less. By having the content of polyhydric alcohol within the above range, the aerosol product is likely to obtain the effects of polyhydric alcohol.

[0021] Examples of solid oils include higher fatty acids such as myristic acid, palmitic acid, stearic acid, and behenic acid, waxes such as beeswax, lanolin, lanolin acetate, candelilla wax, carnauba wax, and montan wax, and higher alcohols such as cetyl alcohol, stearyl alcohol, behenyl alcohol, and myristyl alcohol.

[0022] When a solid oil is contained, the content of the solid oil is not particularly limited. For example, the content of the solid oil in the undiluted solution is preferably 0.1% by mass or more, more preferably 0.3% by mass or more. The content of the solid oil in the undiluted solution is preferably 5% by mass or less, more preferably 3% by mass or less. By having the content of the solid oil within the above range, the effect of the solid oil is easily obtained.

[0023] The powder may be silica, titanium oxide, zinc oxide, zeolite, talc, corn starch, nylon powder, silk powder, urethane powder, silicone powder, polyethylene powder, or the like.

[0024] When powder is contained, the content of the powder is not particularly limited. For example, the content of the powder in the concentrate is preferably 0.1% by mass or more, more preferably 0.2% by mass or more. The content of the powder in the concentrate is preferably 5% by mass or less, more preferably 3% by mass or less. By having the content of the powder within the above range, the aerosol product is likely to obtain the effect of the powder.

[0025] Liquefied gas The liquefied gas is a liquid having vapor pressure in the aerosol container, and forms a homogeneous phase with the concentrate to adjust the pressure of the aerosol composition to a specific range. Also, when the liquefied gas is sprayed to the outside, it vaporizes, atomizing the aerosol composition and making it easier to obtain the effect of the active ingredient.

[0026] The liquefied gas includes liquefied petroleum gas, which is propane, normal butane, isobutane, and mixtures thereof, hydrofluoroolefins such as dimethyl ether, trans-1,3,3,3-tetrafluoroprop-1-ene, trans-2,3,3,3-tetrafluoroprop-1-ene, and mixtures thereof.

[0027] The volume ratio of the concentrate to the liquefied gas (concentrate / liquefied gas) may be 60 / 40 to 5 / 95, and preferably 55 / 45 to 8 / 92. By having the volume ratio of the concentrate to the liquefied gas within the above range, the aerosol product can easily adjust the spray force to a specific range. In particular, when the volume ratio of the concentrate to the liquefied gas is 30 / 70 to 10 / 90, the sprayed aerosol composition has a small particle size and is likely to remain in the sprayed space for a long time, making it easier to obtain the effect of the active ingredient. When the volume ratio of the concentrate to the liquefied gas is greater than 60 / 40, the aerosol product tends to be difficult to spray a predetermined amount because a part of the aerosol composition stored in the metering chamber is not sprayed. In addition, the aerosol product tends to have a spray force of less than 10 gf at a spray distance of 20 cm, making it difficult for the sprayed particles to diffuse. On the other hand, when the volume ratio of the concentrate to the liquefied gas is less than 5 / 95, the aerosol product tends to be difficult to stabilize the spray state.

[0028] (aerosol container) The above-mentioned aerosol composition is filled into an aerosol container. The aerosol container mainly comprises a container body in which the aerosol composition is filled, a metering valve attached to the opening of the container body and equipped with a metering chamber, and an ejection member having an ejection hole for ejecting the aerosol composition.

[0029] The container body is not particularly limited. As an example, the container body includes a cylindrical body portion whose lower end is closed by a bottom portion, a shoulder portion provided so as to taper upward from the upper end of the body portion, and a bead (opening portion) formed in an annular shape at the upper end of the shoulder portion.

[0030] The material of the container body is not particularly limited, but may be, for example, metal such as aluminum or tinplate, synthetic resin such as polyester such as polyethylene terephthalate, or pressure-resistant glass.

[0031] The metered-dose valve has a mounting cup attached to the bead (opening) of the container body, a cylindrical housing fixed to the center of the mounting cup, a stem housed inside the housing so as to be movable up and down, a ring-shaped stem rubber fixed between the mounting cup and the housing and with the stem inserted in the center, and a spring that constantly urges the stem upward. The metered-dose valve of this embodiment also has a metered-dose chamber. The metered-dose chamber stores a fixed amount of the aerosol composition before it is sprayed.

[0032] The housing is cylindrical and has an upper opening and a lower opening, and further has a bottom wall that divides the internal space into an upper opening side and a lower opening side, and has an opening in the central part of the bottom wall that connects the internal space on the upper opening side with the internal space on the lower opening side and allows the lower part of the stem to pass through.

[0033] A cylindrical bush and a dip tube are attached in that order to the lower opening of the housing. A funnel-shaped valve is held between the lower surface of the bottom wall and the bush, with the tip of its lip sliding against the outer circumferential surface of the lower part of the stem.

[0034] The stem has an upper opening and is made up of an upper stem part to which the injection member is attached, and a lower stem part that comes into close contact with the valve and seals when the stem is pressed down. The lower stem part is inserted into the housing so as to pass through an opening in the bottom wall of the housing. The upper opening side of the stem protrudes outward from the housing and communicates with the injection member. The stem has an internal space that forms an injection passage, and a stem hole in the side wall that communicates with the injection passage.

[0035] In the normal state (when not performing the injection operation), the stem rubber closes the stem hole of the stem, which is pushed upward by the spring force, with its inner diameter surface to keep the aerosol container airtight. On the other hand, when injecting, the stem rubber pushes down the injection member to open the seal between the stem rubber and the stem hole, thereby injecting the aerosol composition in the metering chamber to the outside through the injection hole.

[0036] The metered volume chamber is formed by the inner circumferential surface and bottom wall of the housing, and the space up to the stem hole closed by the stem rubber. An expansion unit may be attached to the housing to communicate with the metered volume chamber and increase the volume of the metered volume chamber.

[0037] In a normal state (when no spraying operation is being performed), the metered volume chamber communicates with the inside of the aerosol container, and is filled with the liquid phase of the aerosol composition through the dip tube. When the spray member is pressed down in the axial direction during use, the stem slides against the stem rubber, and the lower part of the stem is first inserted into the valve, blocking the inside of the container body from the metered volume chamber. When the spray member is pressed down further, the stem hole opens. As a result, only the aerosol composition filled in the metered volume chamber is sprayed to the outside through the spray hole of the spray member through the stem hole due to the pressure of the liquefied gas. When the spraying operation is stopped, the stem hole is closed, and the inside of the container body and the metered volume chamber are again connected, and only a certain amount of the aerosol composition inside the container body is filled into the metered volume chamber through the dip tube.

[0038] The pressure (gauge pressure) of the aerosol composition stored in the metering chamber at 25°C may be 0.3 MPa or more, preferably 0.35 MPa or more. The pressure of the aerosol composition stored in the metering chamber may be 0.6 MPa or less, preferably 0.55 MPa or less. By setting the pressure of the aerosol composition stored in the metering chamber within the above range, the aerosol product can easily adjust the spray force to a specific range. When the pressure of the aerosol composition is less than 0.3 MPa, the aerosol product tends to have a spray force of less than 10 gf at a spray distance of 20 cm even if the spray amount per unit time is increased by enlarging the spray hole, and the sprayed particles tend to be difficult to diffuse. On the other hand, when the pressure of the aerosol composition is greater than 0.6 MPa, the aerosol product tends to have a tendency ...

[0039] The injection volume (volume of the metering chamber) of the metering valve may be 0.1 mL or more, and preferably 0.2 mL or more. The injection volume (volume of the metering chamber) of the metering valve may be 2.0 mL or less, and preferably 1.5 mL or less. By having the injection volume within the above range, the aerosol product can be easily adjusted to a predetermined injection force, and the injected aerosol composition can be easily dispersed. In addition, if the injection volume is smaller than 0.1 mL, the aerosol product is less likely to fully obtain the effect of the active ingredient. On the other hand, if the injection volume is larger than 2.0 mL, the aerosol composition stored in the metering chamber of the aerosol product is easily cooled by the heat of vaporization of the liquefied gas accompanying the injection, and the pressure is easily reduced, and a portion of the aerosol composition stored is not injected, making it difficult to inject a predetermined amount.

[0040] The spray member is a component operated by the consumer to spray, and is provided with a mounting part for mounting on the stem of the metered dose valve, and is formed with a spray hole for spraying the aerosol composition to the outside. The area of ​​the spray hole is 0.20 to 2.0 mm 2 It is preferable that the thickness is 0.25 to 1.5 mm. 2 By having the area of ​​the injection hole within the above range, the aerosol product can spray the aerosol composition in the metered dose chamber at an appropriate time, making it difficult for consumers to misuse the aerosol composition. 2 In this case, the aerosol product has a wider range of volume ratio between the concentrate and the liquefied gas to achieve a propelling force exceeding 10 gf at a spray distance of 20 cm, and a wider range of pressure of the aerosol composition stored in the metering chamber. As a result, the aerosol product makes it easier to adjust the particle size and diffusivity of the aerosol composition to be sprayed. Furthermore, even if the volume of the metering chamber is as small as 0.2 to 0.4 mL, the aerosol product is likely to achieve a propelling force exceeding 10 gf at a spray distance of 20 cm. Therefore, the aerosol product is likely to achieve the effect of the active ingredient by spraying a small amount.

[0041] The aerosol composition sprayed from the nozzle turns the original liquid into fine particles (sprayed particles) by vaporization of the liquefied gas. The particle diameter of the sprayed particles, which is the particle diameter D90 at which the volume cumulative distribution value is 90% at a distance of 15 cm from the nozzle, is preferably 8 μm or more, more preferably 10 μm or more. In addition, the particle diameter D90 of the sprayed particles is preferably 100 μm or less, more preferably 80 μm or less.

[0042] The particle diameter of the spray particles is preferably 5 μm or more, more preferably 7 μm or more, in terms of the particle diameter D50 at which the volume cumulative distribution value is 50%, and more preferably 80 μm or less, more preferably 70 μm or less.

[0043] By setting D90 or D50 within the above range, the spray particles are easily dispersed. The particle diameter can be measured by adjusting the aerosol composition to 25° C. and using a spray particle size distribution measuring device Aerotrac II (manufactured by Microtrac Bell Co., Ltd.) at a distance of 15 cm from the spray hole.

[0044] In the aerosol product of this embodiment, the propelling force of the aerosol composition sprayed from the nozzle may be more than 10 gf at a spray distance of 20 cm, and is preferably 11 gf or more. The propelling force is preferably 50 gf or less, and more preferably 45 gf or less. When the propelling force is within the above range, the aerosol product is easy to disperse the sprayed particles. The propelling force can be calculated by adjusting the aerosol product to 25°C, attaching a disk with a diameter of 5.1 cm and a thickness of 1.2 cm to a digital force gauge FGP-0.5 (manufactured by Nidec-Shimpo Corporation), spraying the fixed-dose aerosol product from a position 20 cm away, measuring the maximum load (mN), and converting it into a spray force (g·f).

[0045] The aerosol product of the present embodiment can be produced by a conventional method. For example, the aerosol product can be produced by filling the concentrate into a container body, attaching and sealing a metered-dose valve, filling the container body with liquefied gas, and attaching an ejection member to the valve.

[0046] As described above, in the aerosol product of the present embodiment, the sprayed particles tend to diffuse. EXAMPLES

[0047] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples in any way.

[0048] Example 1 A concentrate A (solvent: ethanol) was prepared according to the recipe shown in Table 1 below, and 14.1 g (30% by volume) was filled into an aluminum container body. A 0.2 mL metered valve was attached to the opening of the container body, and 23.2 g (70% by volume) of 0.40 MPa liquefied petroleum gas was filled at 25°C. Concentrated solution A and the liquefied petroleum gas were mixed in the aerosol container to prepare an aerosol composition. A spray member with a φ0.9 nozzle hole was attached to the stem to produce a metered-dose aerosol product.

[0049] (Examples 2 to 27, Comparative Examples 1 to 23) A metered dose aerosol product was prepared in the same manner as in Example 1, except that the formulation, metered dose valve, and spray component were changed as shown in Table 1.

[0050] The obtained metered dose aerosol product was evaluated for pressure in the metered dose chamber, diffusibility, spray force (20 cm), and particle size (D90, D50) using the following evaluation methods. The results are shown in Table 1.

[0051] [Table 1]

[0052] <Pressure of aerosol composition in the metering chamber> The metered-dose aerosol product was immersed in a thermostatic water bath at 25° C. for 30 minutes to adjust the temperature of the product to 25° C. A pressure gauge was attached to the stem, and the stem was pushed down to the lowest point to isolate the interior of the container body from the metered-dose chamber, and the pressure (MPa, gauge pressure) of the aerosol composition stored in the metered-dose chamber was measured.

[0053] <Diffusion> The metered-dose aerosol product was immersed in a 25°C thermostatic water bath for 30 minutes to adjust the temperature of the product to 25°C. The metered-dose aerosol product was sprayed once in a room (6 tatami mats) with the windows closed. The diffusibility of the spray was evaluated according to the following evaluation criteria. (Evaluation Criteria) ◎: The ejected material spread far from the ejection hole and over a wide area, and remained there for a long time. ○1: The ejected material spread over a wide area and remained there for a long time. ○2: The ejected material spread over a wide area and remained there. ×: The sprayed material spread over a narrow range.

[0054] <Measurement of injection force> The metered-dose aerosol product was immersed in a 25°C thermostatic water bath for 30 minutes to adjust the temperature of the product to 25°C. A disk with a diameter of 5.1 cm and a thickness of 1.2 cm was attached to a digital force gauge FGP-0.5 (Nidec-Shimpo Corporation), and the metered-dose aerosol product was sprayed from a distance of 20 cm. The maximum load (mN) was measured and converted to spray force (g f).

[0055] (Particle size) The fixed-dose aerosol product was adjusted to 25°C, and the 90% particle size (D90) and 50% particle size (D50) in the volumetric distribution at a distance of 15 cm from the spray hole were measured using an Aerotrac II spray particle size distribution analyzer (Microtrack Bell Co., Ltd.).

[0056] As shown in Table 1, the metered dose aerosol products of Examples 1 to 27 of the present invention had a propelling force of more than 10 gf, and the sprayed particles had excellent diffusibility.

Claims

[Claim 1] The aerosol composition comprises a concentrate and a liquefied gas, and an aerosol container in which the aerosol composition is filled, The aerosol container comprises a container body in which the aerosol composition is filled, a metering valve attached to the container body and having a metering chamber, and an ejection member having an ejection hole for ejecting the aerosol composition, The volume ratio of the concentrate to the liquefied gas (concentrate / liquefied gas) is 60 / 40 to 5 / 95; The pressure of the aerosol composition stored in the metering chamber at 25°C is 0.3 to 0.6 MPa; The injection volume of the metered valve is 0.1 to 2.0 mL; The aerosol product of the fixed quantity spray type, wherein the spray force of the aerosol composition sprayed from the spray hole is 10 gf or more at a spray distance of 20 cm.

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