Hair growth promotion composition containing egg shell membrane component and pea sprout extract

Abstract

To provide a safe, oral hair growth promotion composition high in a hair growth promotion effect and capable of being used as a beverage / food product and a supplement.SOLUTION: A hair growth promotion composition containing an egg shell membrane component and a pea sprout extract is highly safe for the human body and skin. Through the synergistic effects of the egg shell membrane component and the pea sprout extract, it enhances the strength and elasticity of hair, thereby enhancing hair gloss. Additionally, it exerts an excellent hair growth promotion effect that promotes growth of the hair itself and increases the number of healthy hairs.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for promoting hair growth, which promotes hair growth and hair regrowth and prevents hair loss. [Background technology]

[0002] The quality and quantity of hair varies from person to person, and some people are born or have been young with a small number of hairs, thin hairs, and other reasons that make their hair appear thin. In addition, as people age, their hair may thin or fall out early, leading to thinning. Furthermore, due to medical reasons such as stress or side effects of drugs, some or all of the hair on the head may fall out, thin, or hair growth may be reduced.

[0003] To solve this problem, various hair growth and hair loss promoters have been developed, such as hair growth agents that contain as active ingredients peptides that promote hair growth and inhibit hair loss (Patent Documents 1 and 2), and those that contain as active ingredients various plant extracts that promote blood circulation and suppress the immune system. However, there are only a few that provide stable and sufficient effects, and some people may experience symptoms such as redness, itchiness, and rashes.

[0004] The eggshell membrane is the membrane inside the eggshell of avian eggs such as chicken eggs. It consists of two membranes, an inner and an outer one, the outer one adheres closely to the inner surface of the eggshell, and the inner one envelops the egg white. It has antibacterial properties and protects the developing embryo from infection. The eggshell membrane has a mesh-like structure made up of tough fibrous proteins mainly composed of type I, type V and type X collagen, glucosamine, desmosine and hyaluronic acid. Many of these proteins contain cystine, and are relatively stable against acids, alkalis and proteases, and insoluble in water. It is known to promote skin regeneration, and is used in cosmetics and nutritional agents.

[0005] In order to solubilize insoluble eggshell membrane in water and increase the digestive and absorption efficiency of eggshell membrane components, eggshell membrane proteins are hydrolyzed in an acid or alkaline aqueous solution or with a protease (Patent Document 3) to produce soluble hydrolyzed eggshell membrane components, which are used as raw materials for supplements and cosmetics. Patent Document 4 also describes that eggshell membrane components have a particularly high hair growth promoting effect when hydrolyzed by enzyme decomposition.

[0006] Furthermore, egg white, which is wrapped in the eggshell membrane, is an ideal food with low fat and high protein nutritional value, and the egg white protein contained therein is an excellent protein with higher nutritional value than other vegetable or animal proteins. After laying, the eggs are incubated for 21 days until a chick hatches from the egg, during which time no nutrition is provided. Since chicks are born with 100% feathers from the moment they are born, chicken eggs contain all the ingredients necessary for hair growth, and it has been reported that egg white, a high-quality protein that is the raw material for hair, and eggshell membrane, which is rich in cystine, have the function of promoting hair growth (Patent Document 5). [Prior art documents] [Patent documents]

[0007] [Patent Document 1] JP 2009-57328 A [Patent Document 2] Patent No. 6393772 [Patent Document 3] Special Publication No. 7-110210 [Patent Document 4] JP 2019-137619 A [Patent Document 5] JP 2022-134216 A Summary of the Invention [Problem to be solved by the invention]

[0008] An object of the present invention is to provide a hair growth promoting composition that has a high hair growth promoting effect, is safe, and can be used as a food, beverage, or supplement. To provide an oral hair growth promoting composition that exerts excellent hair growth and hair growth promoting effects, imparting firmness and elasticity to hair, increasing its luster, and promoting the growth of the hair itself to increase the number of healthy hairs. [Means for solving the problem]

[0009] Chicken eggs contain all the components necessary for chick hair growth, and as a result of intensive research into components that can further enhance the hair growth promoting effect of egg white, a high-quality protein that is the raw material for hair, and eggshell membrane, which is rich in cystine, we discovered that an extract from pea sprouts, a type of germinated vegetable, can significantly enhance the hair growth effect of these egg-derived components, which led to the completion of the present invention.

[0010] The present invention relates to the following hair growth promoting compositions (1) to (5). (1) A composition for promoting hair growth, comprising an eggshell membrane component and a pea sprout extract. (2) The hair growth promoting composition described in (1) above, wherein the eggshell membrane component comprises a hydrolyzed eggshell membrane component, and the pea sprout extract is pea sprout extract powder. (3) A hair growth promoting composition according to (1) above, comprising an egg white component which is egg white powder and / or egg white peptide. (4) The hair growth promoting composition according to (3) above, further comprising egg yolk oil and / or eggshell calcium. (5) A hair growth promoting composition according to any one of (1) to (4) above, which is for oral administration.

[0011] The present invention also relates to the following foods, beverages, or supplements (6) and (7). (6) A food, drink, or supplement comprising the hair growth promoting composition described in (5) above. (7) The food, beverage, or supplement described in (6) above, which is in the form of granules, tablets, capsules, liquid, or a drink. Effect of the Invention

[0012] Among eggshell membrane components, some hydrolyzed eggshell membrane components have a cystine content that is 20 times higher than that of eggshell membrane components, and by combining these hydrolyzed eggshell membrane components with egg white components that contain the sulfur-containing amino acid cystine and egg white proteins with a high content of cysteine, the cystine content necessary for hair can be further increased. Furthermore, by combining egg yolk components such as egg yolk oil and eggshell calcium, all of the components and energy sources of chicken eggs can be utilized. In the present invention, by combining these egg-derived ingredients with an extract of bean sprouts, a type of germinated vegetable (sprout) known for its hair growth promoting effects, the hair growth promoting effects are significantly improved through a synergistic effect, resulting in a hair growth effect that can be felt by the consumer.

[0013] The composition of the present invention can be taken as an oral composition that can be easily taken on a daily basis, such as a food or drink in the form of granules, tablets, capsules, liquids or drinks, or as a supplement. In addition, because egg-derived ingredients and pea sprout extract are natural and highly safe for the human body, there is no adverse effect on health even if they are mixed in large quantities during the manufacture of food, beverages, or supplements. Since it is non-irritating and can be used in combination with various hair growth and hair loss ingredients in various forms, it not only exerts a higher hair growth effect, but also has the inherent effect of promoting beautiful skin and health that egg-derived ingredients have. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0014] The hair growth promoting composition of the present invention is characterized by containing an eggshell membrane component and a pea sprout extract. In this specification, the terms "hair growth" and "hair growth promotion" refer to a hair-growth action that results in an increase in the amount of hair (number, thickness, etc.), an action that increases the growth rate and improves the health of hair, and refers to one or more actions such as promoting hair growth or hair growth, or reducing or preventing hair loss. The hair growth promotion of the present invention includes actions such as promoting hair growth, hair growth, and anti-hair loss.

[0015] The eggshell membrane can be any membrane found inside the shell of any egg of a terrestrial oviparous animal, particularly an avian egg, and is particularly preferably chicken eggshell membrane in terms of availability and cost. The eggshell membrane component of the present invention is preferably in the form of a powder containing at least eggshell membrane, and for example, eggshell membrane powder obtained by powdering an eggshell membrane-containing raw material such as peeled eggshell membrane using a known blender, mixer, mill or grinder, or a commercially available eggshell membrane-containing powder can be used.

[0016] The hydrolyzed eggshell membrane component is a soluble eggshell membrane component obtained by hydrolyzing eggshell membrane or a powder containing eggshell membrane in a liquid that has a protein decomposing effect, such as an acid aqueous solution, an alkaline aqueous solution, an alkaline organic solvent solution, or a liquid containing a protease. The hydrolyzed eggshell membrane component used in the present invention may be produced by any method, but is preferably produced by alkaline hydrolysis and / or enzymatic hydrolysis. It may also be used as an aqueous solution or extract, but in terms of ease of handling and storage stability, it is preferable to use a powder form obtained by drying means such as spray drying or freeze drying.

[0017] As the egg white component of the present invention, liquid egg white, powdered egg white, egg white protein, or egg white peptide can be used, with low molecular weight egg white peptide being preferably used. The egg white protein contained in egg white is low in fat and high in protein, and is high in sulfur-containing amino acids such as cystine, cysteine, and methionine, as well as branched-chain amino acids. In terms of digestion, absorption, and utilization in the body, egg white protein is easily digested and absorbed, and has high nutritional value, compared to other animal proteins such as milk proteins and plant proteins such as soybean proteins. Egg white peptides are produced by breaking down egg white proteins into smaller molecules using an enzyme, and while maintaining the amino acid balance of egg white proteins, they are digested and absorbed faster than egg white proteins. Egg white peptides with an average molecular weight of 200 to 1500, and particularly 600 to 1000, which have a reduced sulfur odor peculiar to egg white, are preferably used.

[0018] Egg yolk oil is a low-alcohol extract of egg yolk obtained by extracting lipids such as lecithin and other oily components from egg yolk with a low-alcohol such as ethanol, and is rich and highly nutritious, containing oily components such as egg yolk lecithin derived from egg yolk. As egg yolk oil, the low-alcohol extract may be used as it is, or the extract may be dried and solidified as necessary, and commercially available products may also be used. Eggshell calcium is a fine powder made by crushing and drying the shells of chicken eggs and other birds, and has a porous structure that makes the calcium components easily absorbed into the body. When added to tablets, it prevents the ingredients from changing or breaking down, and improves the scratch resistance of the tablet surface.

[0019] In addition to eggshell membrane ingredients, the combined use of egg white ingredients containing the sulfur-containing amino acid cystine and egg white protein with a high content of cysteine ​​further increases the cystine content necessary for hair, and by combining this with egg yolk oil and eggshell calcium, you can utilize the power of eggs, which are full of vitality and contain all the components and energy sources of chicken eggs.

[0020] The bean sprouts used as the raw material for the bean sprout extract of the present invention are sprouted vegetables (sprouts) of the pea family, commonly known as bean sprouts, which are made by artificially sprouting pea seeds in the dark and allowing them to grow. It is generally said that sprouts have a concentrated vitality for growth. The bean sprout extract is a water-soluble extract from bean sprouts, and can be obtained, for example, by cutting raw bean sprouts, adding water, and heating at 100° C. for about 30 minutes at normal pressure, or it may be powdered.

[0021] As the pea sprout extract powder used in the present invention, Anagain (H. Holstein Co., Ltd.), which uses sprouts sprouted from organic peas, has been proven to promote hair growth and hair development at an effective dose of 100 mg / day in oral and transdermal clinical trials, and is preferably used.

[0022] In the hair growth promoting composition of the present invention, the content of each of the eggshell membrane component and the pea sprout extract powder is not particularly limited. Since the effective amount of the pea sprout extract powder is 100 mg / day, the content is set to allow the effective amount to be ingested according to the form of use of the hair growth promoting composition of the present invention, and the eggshell membrane component is preferably contained in an amount of 1 to 50% by weight in terms of dry matter. The weight ratio of the egg white component, egg yolk oil, and eggshell calcium is not particularly limited, but since egg yolk oil is an oil and fat component, it is preferably about 1 / 5 or less of the other components. The hair growth promoting composition of the present invention may contain other hair growth active ingredients and various ingredients for improving storage stability, dispersibility, and the like, as required.

[0023] The hair growth promoting composition of the present invention can be an oral composition such as a tablet, powder, granule, capsule, liquid, or drink. Since it is not irritating, there is no particular limitation on the dosage form, and various components and manufacturing methods for producing oral compositions of various dosage forms can be appropriately selected from components known in the manufacturing field of supplements, pharmaceuticals, etc. Tablets are preferred from the viewpoints of being suitable for storage and distribution, not deforming or disintegrating when taken, and being easily taken orally.

[0024] The granules, capsules, or tablets of this embodiment may contain various known additives for forming granules, capsules, or tablets, and may contain excipients, binders, disintegrants, lubricants, other nutrients, and the like. As the excipient, known excipients can be appropriately used, but from the viewpoint of excipient properties, at least one of modified starch and lactose is preferably used in an amount of 0.3 to 3 times, and more preferably 1 to 2.5 times, the weight of the eggshell membrane component. As the modified starch, one or more of dextrins such as roasted dextrin, oxidized starch, low-viscosity modified starch, etc. can be used.

[0025] As the binder, any known binder can be used as appropriate, and examples thereof include starch paste, gum arabic paste, and hydroxypropyl cellulose. As the disintegrant, known disintegrants can be appropriately used, for example, celluloses such as crystalline cellulose, etc. can be used. As the lubricant, known lubricants can be appropriately used, and examples thereof include magnesium stearate, calcium stearate, sucrose fatty acid esters, waxes, talc, vitamin C, and the like.

[0026] Furthermore, the tablet may contain eggshell calcium as a hardness enhancer to increase the tablet hardness, prevent deformation or damage, and improve handling. Eggshell calcium is a fine powder made by crushing and drying the shells of avian eggs such as chicken eggs. Furthermore, it is preferable to cover the tablet with a coating film to prevent the deterioration or decomposition of the ingredients contained in the tablet and to improve the scratch resistance of the tablet surface. The size of the tablet of this embodiment is not particularly limited, but in general, a circular or elliptical shape with a diameter of about 7 to 10 mm is preferable from the viewpoint of ease of handling and administration. Each tablet weighs about 350 to 600 mg, and contains preferably 10 to 240 mg, more preferably 20 to 150 mg, of an active ingredient.

[0027] The liquid preparations for oral use (such as water, suspension, emulsion, syrup, elixir, etc.) and drinks of the present invention are produced by dissolving, suspending, or emulsifying the active ingredient in a commonly used diluent (such as purified water, ethanol, or a mixture thereof.) Furthermore, these liquid preparations may contain emulsifiers, suspending agents, wetting agents, sweeteners, flavorings, preservatives, etc.

[0028] The hair growth promoting composition of the present invention may contain other hair growth active ingredients. For example, preferred are keratin hydrolysate, which is the main component of hair, silk hydrolysate, cystine sources such as L-cystine, Gagniana powder, zinc-containing yeast, etc. As for vitamins, any vitamin can be used, and vitamin B2, which helps maintain the health of the skin and mucous membranes, is particularly effective.

[0029] Furthermore, the oral composition of the present invention can be used as a food additive for confectionery, beverages, health foods, preserved foods, processed foods, etc. Here, the subject of "foods and beverages" and "supplements" is not limited to humans, but also includes feed for mammals such as pets and livestock. In addition, the concept of "foods and beverages" and "supplements" includes not only ordinary foods and beverages, but also enteral nutritional foods, nutritional functional foods, functional foods, foods with specified health uses, etc.

[0030] The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

[0031] [Example 1] Tablet production 40 parts by weight of hydrolyzed eggshell membrane-containing powder (trade name: ESM Protein, Almado Co., Ltd.) and 40 parts by weight of pea sprout extract powder (trade name: Anagain, registered trademark, manufactured by H-Holstein Co., Ltd.) were mixed with 40 parts by weight of egg white peptide (trade name: Egg White Peptide EP-1, manufactured by Kewpie Corporation), 3 parts by weight of egg yolk oil (trade name: Egg Yolk Lecithin PL-30S, manufactured by Kewpie Corporation), and 10 parts by weight of eggshell calcium (trade name: Calhope, manufactured by Kewpie Corporation). Furthermore, keratin hydrolyzate, silk hydrolyzate, L-cystine, Gagnasi powder, zinc-containing yeast, and vitamin B2 were added and mixed using a V-type mixer to prepare a raw material mixture. 15 parts by weight of ethyl alcohol was mixed with 93 parts by weight of this raw material mixture, and the resulting mixture was granulated using a wet granulation device and then dried at a temperature of 50°C for about 16 hours to produce granules for tableting.

[0032] 100 parts by weight of granules for tableting were mixed with 9 parts by weight of vitamin C and 1 part by weight of sucrose fatty acid ester, and the mixture was pressed into a tableting machine to produce plain tablets of 350 mg each. An aqueous solution of the product name "Shellac" (Gifu Shellac Co., Ltd.) was applied to the surface of the plain tablets using a coating machine, and the tablets were dried at a temperature of 40°C for 2 hours to obtain tablets with a protective coating. The polished tablets were selected to remove defective products, and after product inspection, they were weighed and packaged in a double bag containing a desiccant. The tablets had sufficient hardness and shape retention, did not deform or disintegrate during selection, inspection, or packaging, and were easy to handle. Each of the obtained tablets weighed 400 mg and contained 50 mg of eggshell membrane component and 50 mg of pea sprout extract powder.

[0033] [Example 2] Oral test The 24 women, aged between 45 and 65, all reported that they had noticed that the hair on their scalp had become thinner than before, had lost elasticity and strength, and was thinner. Overall, they noticed that their hair volume had decreased. For four months from the start of the study, the subject continued to take two tablets of the tablet produced in Example 1 per day.

[0034] Regarding the condition of their hair four months after starting to take the drug, the subjects were asked to select from multiple answers (1) to (5) the following items for which they felt they had improved: (1) less hair loss, (2) more elasticity, strength, and shine to their hair, (3) more hair overall and more volume, (4) their parting was no longer an issue, and (5) other (hair became cleaner, etc.). The results are shown in Table 1.

[0035] [Table 1]

[0036] The questionnaire also asked participants to voluntarily write their personal impressions, and many responses included, for example, "The amount of hair that falls out after shampooing is really small. I thought it was just a coincidence, but it's low every day. It's more effective than any of the hair care supplements I've taken until now.", "I think my hair is healthier. It stands up better and is shinier.", "Lately I've been losing less hair when shampooing, which is great for not only my hair but also my skin.", and "My hair has become stronger and more resilient, which has given it more volume."

[0037] It has been shown that by ingesting the hair growth promoting composition of the present invention, the condition of the scalp can be improved safely and in a short period of time without side effects, promoting hair growth, and improving the firmness, strength, luster, thickness, number, etc. of hair.

Claims

1. A composition for promoting hair growth, comprising an eggshell membrane component and a pea sprout extract.

2. 2. The hair growth promoting composition according to claim 1, wherein the eggshell membrane component comprises a hydrolyzed eggshell membrane component, and the pea sprout extract is pea sprout extract powder.

3. 2. The hair growth promoting composition of claim 1, comprising an egg white component which is egg white powder and / or egg white peptides.

4. The hair growth promoting composition according to claim 3 , further comprising egg yolk oil and / or eggshell calcium.

5. 5. The hair growth promoting composition according to claim 1, which is for oral administration.

6. A food, drink or supplement comprising the hair growth promoting composition according to claim 5.

7. The food, drink or supplement according to claim 6, which is in the form of granules, tablets, capsules, liquid or drinkable preparations.

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