Agent for improving sickness caused by reduced atmospheric pressure

Abstract

To provide an agent for improving sickness caused by reduced atmospheric pressure.SOLUTION: Gorei-san and / or extract thereof has a great effect of improving a headache occurring when the atmospheric pressure decreases by 2.7-40.5 hPa within 12 hours.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an agent for improving disorders caused by a drop in atmospheric pressure. More specifically, the present invention relates to an agent for improving headaches caused when atmospheric pressure drops by 2.7 to 40.5 hPa within 12 hours. [Background technology]

[0002] The factors that cause or aggravate headaches vary widely from person to person. Typical examples include stress, hunger, sleeping too much or not enough, food, alcohol, menstruation, noise, and odors. However, there are also people for whom changes in weather conditions such as temperature, humidity, rain, and air pressure are factors that cause or aggravate headaches.

[0003] To alleviate headaches, it is necessary to select the appropriate medication depending on the cause. Although there have been several reports of headache medications that are effective for headaches caused by changes in weather conditions, there has been no sufficient research into the relationship between the degree of drop in atmospheric pressure and effective headache medications for headaches caused by a drop in atmospheric pressure.

[0004] On the other hand, Goreisan is a Chinese herbal medicine consisting of Takusha, Chorei, Bukryo, Byakujutsu, and Cinnamon, and is known to be effective for "the following symptoms accompanied by thirst, reduced urine output, nausea, vomiting, abdominal pain, headache, swelling, etc.: watery diarrhea, acute gastroenteritis, heatstroke, headache, swelling," and various Chinese herbal prescriptions using Goreisan have been proposed (see, for example, Patent Document 1).

[0005] However, the efficacy of Goreisan for headaches caused by drops in atmospheric pressure has not been verified in detail, and with conventional technology it is currently not possible to even speculate on the relationship between the magnitude of the drop in atmospheric pressure that causes headaches and the efficacy of Goreisan. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Publication No. 5-43474 Summary of the Invention [Problem to be solved by the invention]

[0007] An object of the present invention is to provide an agent for improving headaches caused by a drop in atmospheric pressure. [Means for solving the problem]

[0008] The present inventors conducted extensive research to solve the above problems and found that Goreisan and / or its extract have an excellent effect of improving headaches caused by atmospheric pressure drops of 2.7 to 40.5 hPa within 12 hours. The present invention was completed based on this finding and further research.

[0009] That is, the present invention provides the following aspects. Item 1. Contains Goreisan and / or its extract as an active ingredient, and has a 2.7-4% This medication is taken to relieve headaches caused by a drop in air pressure when a drop of 0.5 hPa in air pressure is detected. Effect of the Invention

[0010] According to the present invention, it is possible to improve headaches that occur when atmospheric pressure drops by 2.7 to 40.5 hPa within 12 hours, and therefore it is possible to contribute to improving the QOL of people whose constitutions are affected by weather conditions. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] The headache relieving agent of the present invention is an agent for relieving headaches caused by a drop in atmospheric pressure, contains Goreisan and / or an extract thereof as an active ingredient, and is characterized in that it is taken when a drop in atmospheric pressure of 2.7 to 40.5 hPa is observed within 12 hours. The headache relieving agent of the present invention will be described in detail below.

[0012] [Active ingredients] The headache relieving agent of the present invention contains goreisan and / or an extract thereof as an active ingredient.

[0013] Goreisan is a Chinese herbal medicine prescription consisting of Takusha, Chorei, Bukryo, Byakujutsu, and Cinnamon. The amount of each herb that makes up Goreisan is generally 5 parts by weight of Takusha, 3 parts by weight of Chorei, 3 parts by weight of Bukryo, 3 parts by weight of Byakujutsu, and 2 parts by weight of Cinnamon.

[0014] The extract of Goreisan can be obtained by extracting Goreisan (herbal medicine preparation) by a known method. The method of extracting Goreisan may be the same as the conventional method of extracting herbal medicine extracts, for example, a method of adding about 5 to 30 times the amount of water to Goreisan and stirring at about 80 to 100°C for about 1 to 3 hours to extract. After extraction, the solid content is removed by solid-liquid separation such as centrifugation and filtration, and if necessary, the Goreisan extract is obtained by subjecting it to concentration treatment or drying treatment.

[0015] To obtain the extract of Goreisan as an extract powder, the extract liquid from which the solids have been removed may be concentrated as necessary, and then subjected to a drying process such as spray drying, vacuum concentration drying, or freeze drying. When subjected to a drying process (especially a drying process by spray drying), an excipient such as dextrin may be added to the extract liquid as necessary. By adding an excipient in this way, it is possible to shorten the drying time. The type and amount of excipient added are the same as those used in the production of general herbal extract powders.

[0016] To obtain the extract of Goreisan as a soft extract, the extract from which the solids have been removed may be concentrated by vacuum concentration, etc. Alternatively, a suitable adsorbent (e.g., silicic anhydride, starch, etc.) may be added to the soft extract to obtain an adsorbed powder.

[0017] The extract of Goreisan may be in the form of either an extract powder or a soft extract.

[0018] A suitable example of the Goreisan extract used in the present invention is one containing 0.015 to 0.045% by weight of guanosine relative to the total amount of the extract components. Here, the "total amount of the extract components" refers to the total amount of components extracted from Goreisan (herbal medicine compound).

[0019] In the headache relieving agent of the present invention, either Goreisan or an extract thereof may be used alone or in combination.

[0020] In the headache relieving agent of the present invention, the content of Goreisan and / or its extract may be appropriately set depending on the daily dose, dosage form, etc., but for example, the amount of Goreisan in raw herbal medicine equivalent is 8.0 to 16.0 g, preferably 11.2 to 16.0 g, per 2.3 g of the headache relieving agent of the present invention. In the present invention, the "raw herbal medicine equivalent amount of Goreisan" means, in the case of using Goreisan itself, the weight of Goreisan to be blended in the raw herbal medicine equivalent amount, and in the case of Goreisan extract, the dry weight of the total amount of herbal medicine preparation necessary to obtain the amount of Goreisan extract to be blended in the raw herbal medicine equivalent amount.

[0021] [Other ingredients] The headache relieving agent of the present invention may contain other pharmacological ingredients, if necessary, in addition to Goreisan and / or its extract.

[0022] Furthermore, the headache relieving agent of the present invention may contain pharma- ceutically acceptable bases and additives, etc., as necessary, in order to prepare it into a desired dosage form. Examples of such bases and additives include excipients, binders, disintegrants, fluidizing agents, lubricants, isotonicity agents, plasticizers, dispersants, emulsifiers, solubilizing agents, wetting agents, stabilizers, suspending agents, adhesives, coating agents, glossing agents, water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, water-soluble polymers, surfactants, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, UV inhibitors, preservatives, flavoring agents, fragrances, powders, thickeners, dyes, chelating agents, etc. These bases and additives may be used alone or in combination of two or more. The content of these bases and additives may be appropriately set according to the type of additive used and the dosage form of the headache relieving agent.

[0023] [Dosage form] The dosage form of the headache relieving agent of the present invention is not particularly limited, and may be any of a solid preparation, a semi-solid preparation, or a liquid preparation.

[0024] Specific examples of solid preparations include tablets, pills, capsules (soft capsules, hard capsules), powders, granules (including dry syrups), etc. Specific examples of semi-solid preparations include jellies, etc. Specific examples of liquid preparations include solutions, suspensions, syrups, etc.

[0025] Among these dosage forms, from the viewpoints of the stability of the ingredients contained therein, portability, etc., solid preparations are preferred.

[0026] [Dosage and administration] The headache-relieving agent of the present invention is orally administered for the purpose of preventing the onset of headaches caused by a drop in atmospheric pressure or relieving the symptoms thereof.

[0027] The headache relieving agent of the present invention is effective in treating headaches caused by a drop in atmospheric pressure when the atmospheric pressure drops by 2. It is applied to headaches that occur when atmospheric pressure drops by 7 to 40.5 hPa. By applying the headache improving agent of the present invention to headaches caused by such specific drops in atmospheric pressure, an excellent headache improving effect can be achieved. Among such specific headaches, the headache improving agent of the present invention can particularly exhibit an excellent improving effect on headaches that occur when atmospheric pressure drops by 7.3 to 40.5 hPa (particularly 15.8 to 40.5 hPa) within 12 hours.

[0028] When the headache relieving agent of the present invention is taken when a drop in atmospheric pressure within the above range is expected within 12 hours (i.e., before the drop in atmospheric pressure), it can prevent or alleviate headaches caused by the drop in atmospheric pressure. Also, when the headache relieving agent of the present invention is taken after the drop in atmospheric pressure has occurred within the past 12 hours (after the drop in atmospheric pressure), it can alleviate headaches caused by the drop in atmospheric pressure.

[0029] Whether or not a drop in air pressure within the above range will occur within 12 hours can be confirmed based on measured or forecast air pressure values ​​provided by the Japan Meteorological Agency or private weather forecasting companies, depending on the person's place of residence.

[0030] The dosage of the headache relieving agent of the present invention is appropriately determined depending on the age, sex, constitution, etc. of the person to be taken, and can be, for example, 8.0 to 16.0 g, preferably 11.2 to 16.0 g, of Goreisan per day in terms of the original herbal drug amount.

[0031] The headache relieving agent of the present invention may be taken in the above-mentioned dose once to three times a day, preferably two or three times a day. EXAMPLES

[0032] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0033] Test Example 1 Formulation A having the composition shown in Table 1 was prepared. [Table 1]

[0034] The effectiveness of the above formulation in improving "headache" caused by a drop in atmospheric pressure was evaluated for subjects (15 men and women) who sometimes feel unwell due to a drop in atmospheric pressure. Specifically, when a drop in atmospheric pressure was observed, 15 subjects were surveyed on whether they had any subjective symptoms of "headache." Subjects who had the subjective symptoms (headache complainants) were given the formulation, and the severity of the subjective symptoms was evaluated on a five-point scale of "improved," "slightly improved," "unchanged," "slightly worsened," and "worsened" two hours after taking the formulation. Headache complainants who rated the formulation as "improved" or "slightly improved" were counted as those who had noticed the effect, and the ratio of the total number of headache complainants to the total number of headache complainants was calculated as the effectiveness rate (%). The atmospheric pressure at the time of taking the formulation and the maximum atmospheric pressure within 12 hours before taking the formulation were obtained from the data published by the Japan Meteorological Agency. This test was conducted four times on different days using formulation A.

[0035] The results are shown in Table 2. As a result, it was found that the Goreisan extract had an excellent effect of improving headaches caused by a drop in atmospheric pressure of 2.7 to 40.5 hPa within 12 hours (Examples 1 to 4).

[0036] [Table 2]

Claims

[Claim 1] An agent for improving headaches caused by a drop in atmospheric pressure, which contains Goreisan and / or an extract thereof as an active ingredient and is taken when a drop in atmospheric pressure of 2.7 to 40.5 hPa is observed within 12 hours.

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